CN213398363U - Multi-flow path parallel liquid chromatography equipment - Google Patents
Multi-flow path parallel liquid chromatography equipment Download PDFInfo
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- CN213398363U CN213398363U CN202022018165.5U CN202022018165U CN213398363U CN 213398363 U CN213398363 U CN 213398363U CN 202022018165 U CN202022018165 U CN 202022018165U CN 213398363 U CN213398363 U CN 213398363U
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- 238000004811 liquid chromatography Methods 0.000 title claims abstract description 44
- 239000002904 solvent Substances 0.000 claims abstract description 87
- 238000001802 infusion Methods 0.000 claims abstract description 46
- 239000007788 liquid Substances 0.000 claims description 11
- 239000002699 waste material Substances 0.000 claims description 9
- 238000004587 chromatography analysis Methods 0.000 claims description 7
- 238000000105 evaporative light scattering detection Methods 0.000 claims description 5
- 238000004949 mass spectrometry Methods 0.000 claims description 4
- 238000012546 transfer Methods 0.000 abstract description 13
- 238000002360 preparation method Methods 0.000 description 10
- 238000000926 separation method Methods 0.000 description 10
- 238000004458 analytical method Methods 0.000 description 9
- 238000001514 detection method Methods 0.000 description 5
- 150000001875 compounds Chemical class 0.000 description 4
- 239000003153 chemical reaction reagent Substances 0.000 description 3
- 238000012545 processing Methods 0.000 description 3
- 238000001816 cooling Methods 0.000 description 2
- 238000010828 elution Methods 0.000 description 2
- 238000010438 heat treatment Methods 0.000 description 2
- 238000004128 high performance liquid chromatography Methods 0.000 description 2
- 230000007246 mechanism Effects 0.000 description 2
- 238000000034 method Methods 0.000 description 2
- 238000011161 development Methods 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 239000012046 mixed solvent Substances 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000012856 packing Methods 0.000 description 1
- 230000000750 progressive effect Effects 0.000 description 1
- 238000005086 pumping Methods 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
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Abstract
The utility model discloses a parallelly connected liquid chromatography equipment of multithread way, include: a multi-way solvent selector valve, a high-pressure infusion pump and a mixer; the multi-pass solvent selection valve is provided with an outlet and a plurality of inlets which can be respectively communicated with the outlet, and each inlet is respectively used for communicating different solvents; the input end of the high-pressure infusion pump is communicated with the outlet of the multi-way solvent selection valve; the inlet of the mixer is communicated with the output end of the high-pressure infusion pump, and the outlet of the mixer is communicated with the chromatographic column; wherein, the high-pressure transfer pump is two at least, and each high-pressure transfer pump communicates different multi-pass solvent selector valve respectively. This parallelly connected liquid chromatography equipment of multithread way, it is equipped with two at least high-pressure transfer pumps, and each high-pressure transfer pump communicates the different solvent selector valve that leads to, and the solvent variety that can use simultaneously is more, when meetting the problem that needs to change other mobile phases, switches the solvent selector valve that leads to more and can realize, avoids artifical manual change and the solvent of high-pressure transfer pump intercommunication, and the simplified operation improves efficiency.
Description
Technical Field
The utility model relates to an analytical chemistry technical field, more specifically say, relate to a parallelly connected liquid chromatography equipment of multithread way.
Background
The high performance liquid chromatography is a chromatography method in which a predetermined mobile phase is pumped into a column filled with a packing material by a high-pressure infusion pump to separate and measure a sample. The injected test sample is brought into the chromatographic column by the mobile phase, and the components thereof are separated in the column and enter the detector for detection, and the chromatographic number is recorded and arranged by an integrating or data processing system.
Traditional high performance liquid chromatograph generally adopts the high pressure binary pump to carry out the mobile phase input, can only use two kinds of solvents simultaneously, when meetting the problem that needs to change other mobile phases, needs artifical manual change, and the operation is complicated, influences efficiency.
In addition, the chromatographic column is arranged in the column incubator, and the column incubator can only be used for placing 1-2 chromatographic columns, if different separation principles or chromatographic columns of different brands are used for separating and analyzing a plurality of compounds, the high performance liquid chromatograph needs to be stopped from operating, and then the chromatographic columns are manually replaced, so that the analysis process is influenced.
In view of the above, how to provide a high performance liquid chromatography apparatus capable of utilizing multiple mobile phases is a problem to be solved by those skilled in the art.
SUMMERY OF THE UTILITY MODEL
In view of this, the utility model provides a parallelly connected liquid chromatography equipment of multithread way, it is equipped with two at least high-pressure transfer pumps, and the solvent selection valve that leads to that each high-pressure transfer pump intercommunication is different, and the solvent variety that can use simultaneously is more, when meetting the problem that needs to change other mobile phases, switches the solvent selection valve that leads to more and can realize, avoids artifical manual change, and the simplified operation raises the efficiency.
In order to achieve the above object, the utility model provides a following technical scheme:
a multi-flow-path parallel liquid chromatography apparatus comprising:
a multi-pass solvent selector valve having an outlet and a plurality of inlets respectively communicable with the outlet, each of the inlets being respectively for communicating different solvents;
the input end of the high-pressure infusion pump is communicated with the outlet;
the inlet of the mixer is communicated with the output end of the high-pressure infusion pump, and the outlet of the mixer is communicated with the chromatographic column;
the high-pressure infusion pumps are at least two and are respectively communicated with different multi-way solvent selection valves.
Preferably, in the multi-channel parallel liquid chromatography apparatus, the number of the columns is plural;
the multi-flow path parallel liquid chromatography equipment further comprises a multi-pass column position switching valve arranged between the mixer and the chromatographic column, and the multi-pass column position switching valve can enable the mixer to be communicated with different chromatographic columns.
Preferably, in the multi-channel parallel liquid chromatography apparatus, an inlet valve of the multi-pass column-position switching valve is communicated with an outlet of the mixer, and an outlet valve of the multi-pass column-position switching valve is communicated with an inlet of the detector;
the multi-way column position switching valve is provided with an even number of column positions, wherein every two column positions form a group, one column position in each group of column positions can be communicated with the inlet valve, the other column position can be communicated with the outlet valve, and when the multi-way column position switching valve switches gears every time, the group of column positions corresponding to the gears are in a conducting state.
Preferably, in the multi-channel parallel liquid chromatography apparatus, the number of column positions of the multi-pass column position switching valve is 8; the number of the chromatographic columns is 1, 2, 3 or 4.
Preferably, in the multi-channel parallel liquid chromatography apparatus, an outlet of the detector is connected to a waste liquid bottle and a fraction collector through an electromagnetic valve, and the electromagnetic valve controls the outlet of the detector to be communicated with the waste liquid bottle or the fraction collector.
Preferably, in the multi-channel parallel liquid chromatography apparatus, the detector includes one or more of an ultraviolet detector, a diode array detector, an evaporative light scattering detector, and a mass spectrometer detector.
Preferably, in the multi-channel parallel liquid chromatography apparatus, the high-pressure infusion pump is composed of two unit pumps or a multi-element gradient pump.
Preferably, in the multi-channel parallel liquid chromatography apparatus, the multi-pass solvent selection valve is a two-way valve, a four-way valve, a six-way valve, an eight-way valve, or a ten-way valve.
Preferably, in the multi-channel parallel liquid chromatography apparatus, the chromatography column is installed in a column incubator.
Preferably, the multi-channel parallel liquid chromatography apparatus further comprises a degasser, and an input end of the high-pressure infusion pump is communicated with the outlet through the degasser.
The utility model provides a parallelly connected liquid chromatography equipment of multithread way, include: a multi-way solvent selector valve, a high-pressure infusion pump and a mixer; the multi-pass solvent selection valve is provided with an outlet and a plurality of inlets which can be respectively communicated with the outlet, and each inlet is respectively used for communicating different solvents; the input end of the high-pressure infusion pump is communicated with the outlet of the multi-way solvent selection valve; the inlet of the mixer is communicated with the output end of the high-pressure infusion pump, and the outlet of the mixer is communicated with the chromatographic column; wherein, the high-pressure transfer pump is two at least, and each high-pressure transfer pump communicates different multi-pass solvent selector valve respectively.
The utility model provides a parallelly connected liquid chromatography equipment of multithread way, it is equipped with two at least high-pressure infusion pumps, and the solvent selection valve that leads to that each high-pressure infusion pump intercommunication is different, and the solvent variety that can use simultaneously is more, when meetting the problem that needs to change other mobile phases, switches to lead to the solvent selection valve more and can realize, avoids artifical manual change and the solvent of high-pressure infusion pump intercommunication, and the simplified operation improves efficiency.
Drawings
In order to more clearly illustrate the embodiments of the present invention or the technical solutions in the prior art, the drawings used in the description of the embodiments or the prior art will be briefly described below, it is obvious that the drawings in the following description are only some embodiments of the present invention, and for those skilled in the art, other drawings can be obtained according to these drawings without creative efforts.
Fig. 1 is a schematic structural diagram of a multi-flow-path parallel liquid chromatography apparatus provided in an embodiment of the present invention;
wherein, in fig. 1:
a multi-pass solvent selector valve 101; a high pressure infusion pump A, B; a deaerator 102; a mixer 103; a multi-way column position switching valve 104; a column oven 105; a detector 106; a fraction collector 107; a waste bottle 108.
Detailed Description
The embodiment of the utility model discloses parallelly connected liquid chromatography equipment of multithread way, it is equipped with two at least high-pressure transfer pumps, and the solvent selector valve that leads to that each high-pressure transfer pump intercommunication is different, and the solvent variety that can use simultaneously is more, when meetting the problem that needs to change other mobile phases, switches and leads to the solvent selector valve and can realize, avoids artifical manual change, and the simplified operation raises the efficiency.
The technical solutions in the embodiments of the present invention will be described clearly and completely with reference to the accompanying drawings in the embodiments of the present invention, and it is obvious that the described embodiments are only some embodiments of the present invention, not all embodiments. Based on the embodiments in the present invention, all other embodiments obtained by a person skilled in the art without creative work belong to the protection scope of the present invention.
Referring to fig. 1, an embodiment of the present invention provides a multi-flow-path parallel liquid chromatography apparatus, including: a multi-pass solvent selector valve 101, a high pressure infusion pump and mixer 103; the multi-way solvent selection valve 101 is provided with an outlet and a plurality of inlets which can be respectively communicated with the outlet, and each inlet is respectively used for communicating different solvents (each inlet is respectively communicated with a solvent bottle filled with different solvents); the input end of the high-pressure infusion pump is communicated with the outlet of the multi-way solvent selection valve 101; the inlet of the mixer 103 is communicated with the output end of the high-pressure infusion pump, and the outlet is communicated with the chromatographic column; wherein, the high-pressure transfer pump is two at least, and each high-pressure transfer pump communicates different multi-pass solvent selector valve 101 respectively.
The embodiment of the utility model provides a be equipped with two at least high-pressure infusion pumps among the parallelly connected liquid chromatography equipment of multithread way, the different solvent selector valve 101 that leads to of each high-pressure infusion pump intercommunication, the solvent variety that can use simultaneously is more, when meetting the problem that needs to change other mobile phases, switches the solvent selector valve 101 that leads to more and can realize, avoids artifical manual change and the solvent of high-pressure infusion pump intercommunication, and the simplified operation improves efficiency.
Preferably, in the multi-channel parallel liquid chromatography apparatus, the number of columns is plural; the multi-flow path parallel liquid chromatography apparatus further comprises a multi-pass column position switching valve 104 disposed between the mixer 103 and the chromatography column, the multi-pass column position switching valve 104 enabling the mixer 103 to communicate with different chromatography columns, and at the same time, the multi-pass column position switching valve 104 enabling an outlet of the chromatography column to communicate with the detector 106. Of course, the outlet of the chromatographic column may be set to communicate with the fraction collector 107 directly or through the multi-way column position switching valve 104, and this embodiment is not limited thereto.
The equipment that this embodiment provided has additionally set up many post position switch valves 104, makes the free switch of chromatographic column more of quantity, is suitable for the chromatographic column of different separation mechanism and brand to the automatic separation of the great many types of compound of nature difference and analysis, does not need the manual work to change the chromatographic column, and the operation flow is more automatic and high-efficient, greatly reduced equipment and cost of labor.
Specifically, an inlet valve of the multi-way column position switching valve 104 is communicated with an outlet of the mixer 103, and an outlet valve of the multi-way column position switching valve 104 is communicated with an inlet of the detector 106; the multi-way column position switching valve 104 has an even number of column positions, wherein every two column positions are in one group, one column position in each group of column positions can be communicated with the inlet valve, the other column position can be communicated with the outlet valve, and each time the multi-way column position switching valve 104 switches the gear, the column position corresponding to the gear is in a conducting state (even if one column position in the column position corresponding to the gear is communicated with the inlet valve, and the other column position is communicated with the outlet valve).
In the multi-channel parallel liquid chromatography device, the number of column positions of the multi-pass column position switching valve 104 is 8; the number of chromatographic columns is 1, 2, 3 or 4.
The outlet of the detector 106 is connected with a waste liquid bottle 108 and a fraction collector 107 through an electromagnetic valve, and the electromagnetic valve controls the outlet of the detector 106 to be communicated with the waste liquid bottle 108 or the fraction collector 107, so that the device can be used for sample analysis and detection and can also be used for semi-preparation and preparation of samples. The detector 106 is configured to include one or more of an ultraviolet detector, a diode array detector, an evaporative light scattering detector, and a mass spectrometry detector.
In the multi-flow-path parallel liquid chromatography equipment, the high-pressure infusion pump consists of two unit pumps or a multi-element gradient pump. The multi-way solvent selection valve 101 may be a two-way valve, a four-way valve, a six-way valve, an eight-way valve, or a ten-way valve, which is not limited in this embodiment. The column is installed in a column oven 105, the column oven 105 can control the temperature by installing a heating or cooling member, and the column oven 105 can be provided in a cylindrical structure. The multi-channel parallel liquid chromatography device further comprises a degasser 102, and the input end of the high-pressure infusion pump is communicated with the outlet of the multi-channel solvent selection valve 101 through the degasser 102.
The following description of the multi-flow path parallel liquid chromatography apparatus is given in specific embodiments:
example one
This embodiment provides a liquid chromatography equipment that multithread way is connected in parallel, includes: a multi-way solvent selection valve 101, a degasser 102, a high-pressure infusion pump A, a high-pressure infusion pump B, a mixer 103, a multi-way column position switching valve 104, an annular column incubator 105, a detector 106, a fraction collector 107 and a connecting pipeline; the multi-way solvent selection valve 101 is used for selecting different solvent pipelines; a multi-pass column-site switching valve 104 is used for selecting different chromatographic columns to flow through; the detector 106 is used to detect chromatographic signals during the separation process. Through the switching of the multi-pass solvent selection valve 101 and the multi-pass column position switching valve 104, different samples can be analyzed or prepared on one multi-flow-path parallel liquid chromatography device simultaneously by using different mobile phases and different chromatographic columns.
The high-pressure infusion pump A and the high-pressure infusion pump B are both composed of two unit pumps or respectively composed of a multi-element gradient pump, and the number of the infusion pumps can be increased according to the requirement; the high-pressure infusion pump pumps different solvents and mobile phases through a multi-way solvent selection valve 101.
The multi-way solvent selection valve 101 can be a two-way valve, a four-way valve, a six-way valve, an eight-way valve and a ten-way valve, and the inlet of each valve is connected with a solvent pipeline for pumping different solvents; depending on the type of multi-way solvent selector valve 101 used, each solvent line of the high-pressure infusion pump a is labeled a1, a2, A3, a4, a5, a6, a7, A8, a9, a10, each solvent line of the high-pressure infusion pump B is labeled B1, B2, B3, B4, B5, B6, B7, B8, B9, B10, respectively, the outlet of each multi-way solvent selector valve 101 is located at the central outlet valve location; when gradient elution, isocratic mixing of different solvents or gradient elution are performed, two solvents cannot be simultaneously pumped from different solvent pipelines of the solvent pipeline A and two solvents cannot be simultaneously pumped from different solvent pipelines of the solvent pipeline B.
The multi-pass column position switching valve 104 can be a two-way valve, a four-way valve, a six-way valve, an eight-way valve, and a ten-way valve, each valve port is respectively marked as column position 1, column position 2, column position 3, column position 4, column position 5, column position 6, column position 7, column position 8, column position 9, and column position 10 according to the number of inlets of the selected multi-pass column position switching valve 104, the valve port of each multi-pass column position switching valve 104 corresponds to one chromatographic column of the annular column temperature box 105, and the valve port of each multi-pass column position switching valve 104 corresponds to a different chromatographic column.
The annular column oven 105 can be simultaneously provided with one to ten chromatographic columns, and the solvent enters the chromatographic columns through central openings at the top and the bottom of the annular column oven 105 respectively and then enters the detector 106 or the fraction collector 107 through the multi-way column position selector valve 101.
The multi-way column position switching valve 104 corresponds to the annular column temperature box 105, and the valve port of the multi-way column position switching valve 104 is divided into an inlet and an outlet of the chromatographic column and is respectively connected with the central opening positions at the top and the bottom of the annular column temperature box. The number of valve ports of the multi-way column position switching valve 104 is twice the number of chromatographic columns in the annular column temperature box 105, and if the multi-way column position switching valve 104 selects a ten-way valve, at most 5 chromatographic columns can be simultaneously connected in the annular column temperature box 105.
The multi-way solvent selection valve 101 and the multi-way column position switching valve 104 are controlled by electromagnetic valves to be opened, closed and switched.
The annular column oven 105 may be temperature controlled by installing heating or cooling means.
The detector 106 is a variety of devices that can be used for separation, chromatographic signal processing during preparation, including but not limited to an ultraviolet detector 106, a diode array detector 106, an evaporative light scattering detector 106, or a mass spectrometry detector 106, and may be one or a combination of multiple detectors. The outlet of the detector 106 can be connected with a waste liquid bottle 108 or a fraction collector 107, and is controlled and switched by a solenoid valve, so that the detector can be used for sample analysis and detection and can also be used for semi-preparation and preparation of samples.
Example two
In this embodiment, 10 different reagent bottles are respectively used for storing 10 different reagents or mobile phases, and are connected to the inlet end of the high-pressure infusion pump a or B through 10 different solvent delivery pipelines and a ten-way solvent selector valve. One end of the ten-way solvent selection valve is connected with a reagent bottle, the other end of the ten-way solvent selection valve is connected with a high-pressure infusion pump, and the solvent selection valve positions are respectively named as A1-A10 and B1-B10 according to the difference of the connected high-pressure infusion pumps. All solvents are input from 1-10 positions of one solvent selection valve through high-pressure infusion A or B, and an outlet is positioned at the middle position of each ten-position solvent selection valve. If two solvents are required, the two solvents can be respectively input through a certain valve position of a solvent selection valve connected with the high-pressure infusion pump A and the high-pressure infusion pump B at the same time, but the two solvents cannot be input from the two valve positions of the high-pressure infusion pump A, for example, the two solvents cannot be simultaneously pumped at the valve positions A1 and A2, and similarly, the two solvents cannot be simultaneously pumped at the valve positions B1 and B2.
The solvent is delivered by the high-pressure infusion pump a or the high-pressure infusion pump B and then mixed in the mixer 103. The mixed solvent enters the column through a multi-way column-position switching valve 104. The multi-way column position switching valve 104 selects an eight-way valve, each valve port is respectively marked as a column position 1, a column position 2, a column position 3, a column position 4, a column position 5, a column position 6, a column position 7 and a column position 8, wherein the column position 1 is communicated with the column position 5 at the opposite position, the column position 2 is communicated with the column position 6 at the opposite position, the column position 3 is communicated with the column position 7 at the opposite position, the column position 4 is communicated with the column position 8 at the opposite position, and the multi-way column position switching valve 104 controls the switching of the valve ports through an electromagnetic valve. The outlet ends of the column position 1, the column position 2, the column position 3 and the column position 4 of the eight-way column position switching valve are connected with different chromatographic columns of the annular column temperature box 105, and the column position 5, the column position 6, the column position 7 and the column position 8 of the eight-way column position switching valve are respectively connected with outlets of the different chromatographic columns. And liquid at the column positions 5, 6, 7 and 8 of the eight-way column position switching valve is discharged through an outlet valve positioned at the central position of the eight-way column position switching valve.
The annular column temperature box 105 can be simultaneously provided with one to four chromatographic columns, the solvent enters the chromatographic columns through the top of the annular column temperature box 105 respectively, and the solvent flows from the outlet of the chromatographic columns to the detector 106 through the multi-way column position switching valve 104.
The detector 106 is a variety of devices that can be used for separation, chromatographic signal processing during preparation, and can be selected from an ultraviolet detector, a diode array detector, an evaporative light scattering detector, or a mass spectrometry detector, which can be one or a combination of a plurality of detectors, according to the purpose of use and the nature of the compound. The outlet of the detector can be connected with a waste liquid bottle or a fraction collector, and is controlled and switched by an electromagnetic valve, so that the device can be used for sample analysis and detection and can also be used for semi-preparation and preparation of samples.
The multi-flow-path parallel liquid chromatography equipment provided by the embodiment designs a multi-flow-path liquid chromatography system by adding components such as a multi-pass solvent selection valve 101, a multi-pass column switching position valve 104, an annular column temperature box 105 and the like, and can realize automatic separation and analysis of various compounds with large property differences by using various mobile phases, various different separation mechanisms and chromatographic columns of brands on one piece of equipment through control and switching of the electromagnetic valve, the mobile phases and the chromatographic columns do not need to be manually replaced, the operation flow is more automatic and efficient, and the equipment and labor cost is greatly reduced. And simultaneously, the embodiment of the utility model provides an equipment both can be used to the analytical method development of sample analysis detection, different chromatographic columns, also can be used to sample preparation, through selecting different mobile phase and chromatographic column, makes the sample separation of different properties, different separation type more automatic and high-efficient, when improving sample analysis and preparation efficiency, also can reduce chromatographic system's input cost
The embodiments in the present description are described in a progressive manner, each embodiment focuses on differences from other embodiments, and the same and similar parts among the embodiments are referred to each other.
The previous description of the disclosed embodiments is provided to enable any person skilled in the art to make or use the present invention. Various modifications to these embodiments will be readily apparent to those skilled in the art, and the generic principles defined herein may be applied to other embodiments without departing from the spirit or scope of the invention. Thus, the present invention is not intended to be limited to the embodiments shown herein but is to be accorded the widest scope consistent with the principles and novel features disclosed herein.
Claims (10)
1. A multi-flow parallel liquid chromatography apparatus, comprising:
a multi-pass solvent selector valve having an outlet and a plurality of inlets respectively communicable with the outlet, each of the inlets being respectively for communicating different solvents;
the input end of the high-pressure infusion pump is communicated with the outlet;
the inlet of the mixer is communicated with the output end of the high-pressure infusion pump, and the outlet of the mixer is communicated with the chromatographic column;
the high-pressure infusion pumps are at least two and are respectively communicated with different multi-way solvent selection valves.
2. The multi-flow parallel liquid chromatography apparatus of claim 1, wherein said chromatography column is plural;
the multi-flow path parallel liquid chromatography equipment further comprises a multi-pass column position switching valve arranged between the mixer and the chromatographic column, and the multi-pass column position switching valve can enable the mixer to be communicated with different chromatographic columns.
3. The multi-flow parallel liquid chromatography apparatus of claim 2, wherein the inlet valve of the multi-pass column-position switching valve is in communication with the outlet of the mixer and the outlet valve of the multi-pass column-position switching valve is in communication with the inlet of the detector;
the multi-way column position switching valve is provided with an even number of column positions, wherein every two column positions form a group, one column position in each group of column positions can be communicated with the inlet valve, the other column position can be communicated with the outlet valve, and when the multi-way column position switching valve switches gears every time, the group of column positions corresponding to the gears are in a conducting state.
4. The multi-flow parallel liquid chromatography apparatus of claim 3, wherein the multi-pass column-position switching valve has 8 column positions; the number of the chromatographic columns is 1, 2, 3 or 4.
5. The multi-flow parallel liquid chromatography apparatus of claim 3, wherein the outlet of the detector is connected to a waste liquid bottle and a fraction collector through a solenoid valve, and the solenoid valve controls the outlet of the detector to communicate with the waste liquid bottle or communicate with the fraction collector.
6. The multi-flow parallel liquid chromatography apparatus of claim 3, wherein the detector comprises one or more of an ultraviolet detector, a diode array detector, an evaporative light scattering detector, a mass spectrometry detector.
7. The multi-flow parallel liquid chromatography apparatus of claim 1, wherein said high pressure infusion pump consists of two unit pumps, or one multi-element gradient pump.
8. The multi-flow parallel liquid chromatography apparatus of claim 1, wherein the multi-pass solvent selector valve is a two-way valve, a four-way valve, a six-way valve, an eight-way valve, or a ten-way valve.
9. The multi-flow parallel liquid chromatography apparatus of claim 1, wherein said chromatography column is mounted in a column incubator.
10. The multi-flow parallel liquid chromatography apparatus of claim 1, further comprising a degasser through which an input of the high pressure infusion pump communicates with the outlet.
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Inventor after: Yuan Yu Inventor after: Deng Xuepeng Inventor after: Huang Bo Inventor after: Luo Min Inventor after: Li Yuanbo Inventor after: Wang Binrong Inventor after: Li Kerui Inventor after: Gao Jian Inventor before: Deng Xuepeng Inventor before: Huang Bo Inventor before: Luo Min Inventor before: Li Yuanbo Inventor before: Yuan Yu Inventor before: Wang Binrong Inventor before: Li Kerui Inventor before: Gao Jian |
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Address after: 610000 Chengdu Tianfu International Biological City, Chengdu, Sichuan Province (No. 618 Fenghuang Road, Shuangliu District, Building 6, No. 301, 401, 402) Patentee after: CHENGDU NUOHE SHENGTAI BIOTECHNOLOGY Co.,Ltd. Address before: 610000 Chengdu Tianfu international biological city, Chengdu, Sichuan Province (No.18, Section 2, middle biological city road, Shuangliu District) Patentee before: CHENGDU NUOHE SHENGTAI BIOTECHNOLOGY Co.,Ltd. |