CN213364798U - Waste liquid needle detection device for cleaning and separating waste liquid of chemiluminescence analyzer - Google Patents
Waste liquid needle detection device for cleaning and separating waste liquid of chemiluminescence analyzer Download PDFInfo
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- CN213364798U CN213364798U CN202022248628.7U CN202022248628U CN213364798U CN 213364798 U CN213364798 U CN 213364798U CN 202022248628 U CN202022248628 U CN 202022248628U CN 213364798 U CN213364798 U CN 213364798U
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Abstract
The application relates to a waste liquid needle detection device for cleaning and separating waste liquid of a chemiluminescence analyzer, which comprises a light-emitting source, a photoelectric sensor, a comparator and a single chip microcomputer, wherein the light-emitting source and the photoelectric sensor are respectively arranged on two sides of a set position of a transparent waste liquid pipeline; one input end of the comparator is connected with the electric signal output end of the photoelectric sensor, the other input end of the comparator is connected with reference voltage, and the output end of the comparator is connected with the single chip microcomputer; the singlechip determines the time that the photoelectric sensor detects the waste liquid by detecting the voltage change of the output end of the photoelectric sensor, thereby judging whether the waste liquid needle is blocked or not. The detection reliability is high, and the probability of misjudgment of the blocked needle is greatly reduced.
Description
Technical Field
The application belongs to the technical field of medical instrument, concretely relates to chemiluminescence analysis appearance washs waste liquid needle detection device of separation waste liquid.
Background
The diagnosis method, in vitro diagnosis, which is the most commonly used method in the medical field at present, refers to collecting body fluid, excrement and secretion of a human body to perform chemical composition or chemical reaction analysis so as to judge human body pathological changes. Such as chemiluminescence analysis and molecular diagnosis. The diagnosis methods adopt automatic or semi-automatic instruments to sample and analyze, and give a diagnosis report.
Chemiluminescence analysis is the latest immunoassay technology developed after radioimmunoassay, fluorescence immunoassay and enzyme immunoassay, has the advantages of high sensitivity, wide detection range, good marker stability and the like, and is increasingly becoming an important means of in vitro immunoassay. In the working process of the full-automatic chemiluminescence analyzer designed based on the chemiluminescence principle, the cleaning and separation of reactants are key links of immunoassay, and the cleaning effect has great influence on the accuracy of test results.
At present, a cleaning needle structure is arranged in a cleaning and separating device of a chemiluminescence analyzer, and when a reaction cup is driven in a cleaning area, the cleaning needle structure is repeatedly lifted or lowered to automatically absorb and inject cleaning liquid, so that a magnetic separation cleaning effect is achieved. The cleaning needle structure of a chemiluminescence analyzer generally needs to comprise two needles: one is a waste liquid needle which is used for absorbing waste liquid in the reaction cup; the other is a washing needle used for injecting washing liquid into the reaction cup.
In the chemiluminescence immunoassay test process, the cleaning and separating effect directly determines the accuracy of chemiluminescence detection. The cleaning and separating function is abnormal, and particularly when the needle is blocked by the cleaning and separating waste liquid needle, the reliability of the final luminescence detection result of the analyzer is necessarily influenced. The existing method for detecting, cleaning and separating the blocked needle is mostly judged by using a probe conduction mode.
SUMMERY OF THE UTILITY MODEL
The to-be-solved technical problem of the utility model is: in order to solve the problem that the detection reliability is influenced when the needle is blocked during the cleaning and separating of the waste liquid needle in the chemiluminescence immunoassay test process, the waste liquid needle detection device for cleaning and separating the waste liquid of the chemiluminescence analyzer is provided.
The utility model provides a technical scheme that its technical problem adopted is: a waste liquid needle detection device for cleaning and separating waste liquid of a chemiluminescence analyzer comprises a waste liquid position detection circuit, a comparator and a single chip microcomputer, wherein the waste liquid position detection circuit is installed on a transparent waste liquid pipeline connected with a waste liquid needle, the waste liquid position detection circuit comprises a luminous source and a photoelectric sensor, the luminous source and the photoelectric sensor are respectively arranged on two sides of a set position of the transparent waste liquid pipeline, and the photoelectric sensor is used for receiving an optical signal sent by the luminous source and converting the optical signal into a voltage signal to be output;
one input end of the comparator is connected with the electric signal output end of the photoelectric sensor, the other input end of the comparator is connected with reference voltage, and the output end of the comparator is connected with the single chip microcomputer;
the singlechip determines the time that the photoelectric sensor detects the waste liquid by detecting the voltage change of the output end of the photoelectric sensor, thereby judging whether the waste liquid needle is blocked or not.
As an embodiment, the waste liquid needle detection device described in the present application further includes a digital potentiometer, wherein the digital potentiometer is connected to the output end of the photoelectric sensor and is used for providing an adjustable resistor to adjust the output voltage of the photoelectric sensor to a reference value.
Furthermore, this application waste liquid needle detection device, still include filter circuit, filter circuit connects the signal of telecommunication output at photoelectric sensor for carry out the output to the comparator after filtering with the voltage signal of photoelectric sensor output.
Furthermore, the waste liquid needle detection device of this application still includes schmitt trigger phase inverter, schmitt trigger phase inverter connects the output at the comparator for the voltage waveform of output after the shaping comparison, and export to the singlechip.
Furthermore, this application waste liquid needle detection device, filter circuit is RC high pass filter circuit.
Further, in the waste liquid needle detecting device of the present application, the schmitt trigger inverter employs 74HC 14.
Furthermore, this application waste liquid needle detection device, photoelectric sensor is phototransistor, phototransistor's base level is light receiving port, phototransistor's collecting electrode power connection's positive pole, phototransistor's projecting pole warp one of them voltage input end of filter circuit access comparator.
The utility model has the advantages that: the utility model discloses a detection reliability is high, greatly reduced the probability of stifled needle erroneous judgement.
Drawings
The technical solution of the present application is further explained below with reference to the drawings and the embodiments.
FIG. 1 is a schematic diagram of a structure of a waste liquid needle detection device according to an embodiment of the present application;
fig. 2 is a schematic view of the installation position of a waste liquid position detection circuit according to an embodiment of the present application;
FIG. 3 is a circuit schematic of an embodiment of the present application;
FIG. 4 shows a voltage signal V according to an embodiment of the present applicationR1And VR2To generate a circuit diagram.
In the figure, 1 is a reaction cup, 2 is a transparent waste liquid pipeline, 3 is a waste liquid position detection circuit, 4 is a filter circuit, and 5 is a comparator circuit.
Detailed Description
It should be noted that the embodiments and features of the embodiments in the present application may be combined with each other without conflict.
The technical solutions of the present application will be described in detail below with reference to the accompanying drawings in conjunction with embodiments.
The cleaning needle structure of the chemiluminescence analyzer comprises a cleaning needle and a waste liquid needle, wherein the cleaning needle is used for injecting cleaning liquid into the reaction cup, and the waste liquid needle is used for absorbing waste liquid in the reaction cup.
The application provides a waste liquid needle detection device mainly used detects the waste liquid needle and is absorbing the in-process of waste liquid, whether takes place stifled needle.
Example 1
The embodiment provides a waste liquid needle detection device for cleaning and separating waste liquid of a chemiluminescence analyzer, which comprises a waste liquid position detection circuit, a single chip microcomputer, a filter circuit, a comparator circuit and a digital potentiometer, and is shown in figure 1.
As shown in fig. 2, the waste liquid position detecting circuit is installed on the transparent waste liquid pipeline 2 connected to the waste liquid needle, and includes a light emitting source and a photoelectric sensor, which are respectively disposed on two sides of the set position of the transparent waste liquid pipeline.
In this embodiment, as a feasible implementation, the light source employs an infrared light emitting diode, the photosensor employs a phototransistor, a base of the phototransistor is a light receiving port, and is configured to receive an optical signal transmitted by the infrared light emitting diode, a collector of the phototransistor is connected to an anode of the power supply, and an emitter of the phototransistor is an electrical signal output port of the phototransistor and is configured to convert the received optical signal into an electrical signal for output.
When the chemiluminescence analyzer does not suck waste liquid, no liquid flows through a transparent waste liquid pipeline connected with the waste liquid needle, and an optical signal received by the photoelectric transistor is unobstructed; when the waste liquid absorbing action is carried out and liquid in the transparent waste liquid pipeline flows through the position between the infrared light emitting diode and the phototransistor, the waste liquid shields the optical channel, and the phototransistor cannot detect an optical signal or detects a small optical signal, so that the output current of the phototransistor is reduced, and the corresponding voltage is reduced.
When the waste liquid flows through, the output voltage of the photoelectric transistor is reduced, the voltage variation is detected by using the filter circuit, then the voltage variation signal is processed by the comparison circuit and the shaping circuit and is input to the singlechip, and the singlechip rapidly detects the voltage variation signal by using an edge interruption triggering mode.
As shown in fig. 3, in the waste liquid position detecting circuit 3 of the present embodiment, the phototransistor is SD3443, the emitter of the phototransistor is connected to a digital potentiometer through a resistor R43, the digital potentiometer is used to provide an adjustable resistor Radj, the current signal output by the phototransistor flows through a resistor R43 to generate a voltage signal, so that the current signal output by the phototransistor is converted into a voltage signal, and when there is no liquid in the transparent waste liquid pipeline, the output voltage of the phototransistor is adjusted to the reference voltage V by adjusting the resistance of the digital potentiometer12.5V. The filter circuit 4 is an RC high-pass filter circuit formed by serially connecting capacitors C32 and R44, the comparator circuit 5 comprises a comparator LM2903, an output voltage signal of an emitter of the phototransistor SD3443 passes through the filter circuit 4 and is output to a positive input end of the comparator LM2903, and a negative input end of the comparator LM2903 is connected with a reference voltage VR2One end of the resistor R44 is connected to the positive input end of the comparator LM2903, and the other end is connected to the voltage VR1。
The output voltage (V) of the filter circuit is compared by a comparator LM2903R1-V1) And a reference voltage VR2Making a comparison when (V)R1-V1)>VR2Time, voltage signal V output by comparatorpreIs a high level signal; when (V)1-VR1) Down to VR2The voltage signal V output by the comparatorpreFlipping occurs, producing a falling edge pulse. When the detector is turned over, the voltage value required by the fluctuation voltage is small, and accordingly the detection sensitivity is improved.
As shown in fig. 4, the voltage signal VR1And VR2The voltage signal acquisition circuit is obtained by a R46, R48 and R50 series circuit and a chip LM358, wherein the LM358 is an operational amplifier formed by double operational amplifiers, in the embodiment, the LM358 is used as a front end voltage follower for voltage signal acquisition, a power supply end of the LM358 is connected to a 5V power supply, and a series point of R46 and R48 is connected to No. 3 of the LM358Pin, output VR1(ii) a V is output by connecting the serial connection points of R48 and R50 into No. 5 pin of LM358R2。
The voltage signal output by the comparator LM2903 is sent to the Schmitt trigger inverter 74HC14, and the Schmitt trigger inverter 74HC14 is used for shaping the voltage waveform output by the comparator and outputting the shaped voltage waveform to the single chip microcomputer. When the falling edge pulse output by the comparator is shaped and inverted by 74HC14, the rising edge pulse is generated and output to the singlechip.
When the singlechip detects that the waste liquid needle descends, timing is started until the timing is stopped after the rising edge pulse output by 74HC14, so that the time interval from the beginning of descending of the waste liquid needle to the rising edge of the output pulse of 74HC14 is determined, and if the time interval exceeds the set threshold range, the waste liquid needle is judged to be blocked.
Because the flow rate of the waste liquid sucked by the waste liquid needle in the transparent waste liquid pipeline is constant under the condition that the waste liquid needle is not blocked, the time for the waste liquid needle to suck the waste liquid to flow through the photoelectric transistor is also constant, once the waste liquid needle is blocked, the flow rate of the waste liquid in the transparent waste liquid pipeline is reduced, and the time for the waste liquid to flow through the photoelectric transistor is later than the set time, therefore, when the time interval exceeds the set threshold range, the waste liquid needle can be judged to be blocked.
The resistance adjustment of the digital potentiometer is controlled in an IIC communication mode, the reference voltage V1 is input into the single chip microcomputer, the single chip microcomputer carries out AD conversion on a reference voltage signal, and the resistance value of the digital potentiometer is adjusted in the IIC communication mode, so that the reference voltage output by the photoelectric transistor is maintained at 2.5V when liquid is not absorbed, and the digital potentiometer can be self-adjusted to adapt to different environmental conditions.
The singlechip adopts a Tiny84 series singlechip, and mainly carries out AD conversion reference voltage, IIC communication adjustment digital potentiometer and voltage pulse signal external interrupt processing.
Example 2:
because the chemiluminescence analysis appearance is provided with a plurality of reaction cups usually, when detecting simultaneously to a plurality of waste liquid needles that a plurality of reaction cups of chemiluminescence analysis appearance correspond, because before the waste liquid needle absorbs the waste liquid, initial waste liquid volume in the different reaction cups probably has the difference, the moment that contacts the waste liquid when the waste liquid needle absorbs the waste liquid will be different, because many waste liquid needles begin to descend the imbibition simultaneously at same height, and be same imbibition pump control, the waste liquid needle that different reaction cups correspond like this begins to descend and triggers phototransistor time interval will be different. In this case, if the single chip microcomputer determines whether each waste liquid needle is blocked according to a certain set time when the rising edge pulse is detected, the possibility of erroneous determination may occur.
In this case, in this embodiment, in addition to embodiment 1, different time interval thresholds for starting the descending of the waste liquid needle and triggering the rising edge of the output pulse of the phototransistor are set according to the initial amount of waste liquid in different reaction cups, and whether the waste liquid needle is blocked or not is determined according to the time difference between the descending of different waste liquid needles and the flowing of waste liquid through the phototransistor during actual measurement.
In another embodiment, the amount of the waste liquid remaining in different reaction cups can be recorded, and whether the waste liquid needle is blocked can be judged according to the amount of the remaining waste liquid.
In light of the foregoing description of the preferred embodiments according to the present application, it is to be understood that various changes and modifications may be made without departing from the spirit and scope of the invention. The technical scope of the present application is not limited to the contents of the specification, and must be determined according to the scope of the claims.
Claims (7)
1. A waste liquid needle detection device for cleaning and separating waste liquid of a chemiluminescence analyzer is characterized by comprising a waste liquid position detection circuit, a comparator and a single chip microcomputer, wherein the waste liquid position detection circuit is arranged on a transparent waste liquid pipeline connected with a waste liquid needle, the waste liquid position detection circuit comprises a luminous source and a photoelectric sensor, the luminous source and the photoelectric sensor are respectively arranged on two sides of a set position of the transparent waste liquid pipeline, and the photoelectric sensor is used for receiving an optical signal sent by the luminous source and converting the optical signal into an electric signal for outputting;
one input end of the comparator is connected with the electric signal output end of the photoelectric sensor, the other input end of the comparator is connected with reference voltage, and the output end of the comparator is connected with the single chip microcomputer;
the singlechip determines the time that the photoelectric sensor detects the waste liquid by detecting the voltage change of the output end of the photoelectric sensor, thereby judging whether the waste liquid needle is blocked or not.
2. The waste liquid needle detection device according to claim 1, further comprising a digital potentiometer connected to an output terminal of the photoelectric sensor for providing an adjustable resistance to adjust an output voltage of the photoelectric sensor to a reference value.
3. The waste liquid needle detection device according to claim 1, further comprising a filter circuit, wherein the filter circuit is connected to the electrical signal output terminal of the photoelectric sensor, and is configured to filter the electrical signal output by the photoelectric sensor and output the filtered electrical signal to the comparator.
4. The waste liquid needle detection device according to claim 1, further comprising a schmitt trigger inverter connected to an output of the comparator for shaping the compared output voltage waveform to the single chip.
5. The waste needle detection device of claim 3, wherein the filter circuit is an RC high-pass filter circuit.
6. The waste liquid needle detecting device according to claim 4, wherein 74HC14 is used as the Schmitt trigger inverter.
7. The waste liquid needle detection device according to claim 3, wherein the photosensor is a phototransistor, a base of the phototransistor is a light receiving port, a collector of the phototransistor is connected to a positive electrode of a power supply, and an emitter of the phototransistor is connected to one of voltage input terminals of a comparator through the filter circuit.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
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| CN201921805949 | 2019-10-25 | ||
| CN2019218059493 | 2019-10-25 |
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| CN213364798U true CN213364798U (en) | 2021-06-04 |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN115193812A (en) * | 2022-07-28 | 2022-10-18 | 南京仁迈生物科技有限公司 | Cleaning station system of chemiluminescence detector |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN115193812A (en) * | 2022-07-28 | 2022-10-18 | 南京仁迈生物科技有限公司 | Cleaning station system of chemiluminescence detector |
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