CN213217825U

CN213217825U - Stress modeling tool for chronic unpredictable liver depression and spleen deficiency syndrome of large and small mice

Info

Publication number: CN213217825U
Application number: CN202021193091.2U
Authority: CN
Inventors: 蒋志滨; 高洁; 柴艺汇; 陈云志; 李文
Original assignee: Guizhou University of Traditional Chinese Medicine
Current assignee: Guizhou University of Traditional Chinese Medicine
Priority date: 2020-06-24
Filing date: 2020-06-24
Publication date: 2021-05-18
Anticipated expiration: 2030-06-24

Abstract

The utility model discloses a chronic unpredictable big, mouse liver depression spleen deficiency syndrome stress modeling instrument relates to mouse experiment instrument technical field, and this chronic unpredictable big, mouse liver depression spleen deficiency syndrome stress modeling instrument, be provided with fixed pipe on the base, the surface activity of fixed pipe has cup jointed the sleeve pipe, the top threaded connection of fixed pipe has the knob, the sheathed tube side surface is provided with five baffles, five the baffle is respectively with regional division regional one around the sleeve pipe, regional two, regional three, regional four and regional five, all be provided with the horizontal pole between the baffle of regional one and regional two both sides. The utility model discloses a set up constraint rope, connect rope, spring clamp, frame plate, fixer, baffle, loudspeaker, food steamer and control by temperature change stick, solved and generally adopted a series of instrument combinations to experiment in the current chronic unpredictable liver depression spleen deficiency syndrome stress experiment, lead to that whole process is complicated loaded down with trivial details, bring inconvenient problem for the experiment.

Description

Stress modeling tool for chronic unpredictable liver depression and spleen deficiency syndrome of large and small mice

Technical Field

The utility model relates to a mouse experiment tool technical field specifically is a chronic unpredictable big, mouse liver depression spleen deficiency syndrome stress modeling tool.

Background

The laboratory mouse, the white mouse and the white mouse refer to a white fur rat or a white fur mouse which is generally used as a laboratory animal in teaching and research of physiological, medical, pharmaceutical and other subjects. Rats are a collective term for many rodents in the family muridae, often referring to many unrelated species in the family, in particular to the genus murus, about 80 species, throughout the old continent; the mouse is developed from little mouse, it is widely distributed all over the world, through long-term artificial breeding selection, have bred more than 1000 inbred lines and independent distant cross group, have had human mouse to do the experiment as early as 17 th century, have become the largest using amount, study the most detailed mammalian experimental animal now. Therefore, in the stress experiment of the chronic unpredictable liver depression and spleen deficiency syndrome, rats and mice are selected for the experiment.

In the chronic unpredictable stress experiment of liver depression and spleen deficiency syndrome, the stress stimulation combination comprises restraint, tail clamping, electric shock on soles, noise stimulation and heat stress, one of the stimulation modes is randomly selected every day, and the same stimulation is not continuously generated for two days, so that the stimulation of animals cannot be predicted. The binding method is that the two forelimbs of the experimental mouse are reversely bound to the back by using a cotton rope, the hind limbs are free, the scratching of the head and the face by the forelimbs of the experimental mouse is limited, the binding time is 40min, and the binding time is 1d/2 times; clamping tail refers to clamping tail of experimental mouse with clamp for 1 min; the electric shock is applied to the sole of the foot by adopting the voltage of 50mV for 10s continuously, and the electric shock is stimulated for 1 time every 30s for 15 times; the noise stimulation refers to placing a laboratory mouse in a noise environment, adopting 60Hz noise, and the stimulation time is lh; the heat stress is obtained by placing the experimental mouse in a heat environment for 5 min.

The existing chronic unpredictable liver depression and spleen deficiency syndrome stress experiment generally adopts a series of tool combinations to carry out the experiment, tools and assemblies are required before each experiment, the steps of splitting, classifying, storing and the like are required after the experiment is finished, the whole process is complex and tedious, and inconvenience and defects are brought to the experiment.

SUMMERY OF THE UTILITY MODEL

Technical problem to be solved

The not enough to prior art, the utility model provides a chronic unpredictable big, mouse liver qi stagnation spleen deficiency syndrome stress modeling instrument has solved and has generally adopted a series of instrument combinations to experiment in the current chronic unpredictable liver qi stagnation spleen deficiency syndrome stress experiment, leads to whole process complicacy loaded down with trivial details, brings inconvenient problem for the experiment.

(II) technical scheme

In order to achieve the above object, the utility model provides a following technical scheme: the utility model provides a chronic unpredictable big, mouse liver depression spleen deficiency syndrome stress modeling tool, is provided with fixed pipe on including the base, the sleeve pipe has been cup jointed in the surface activity of fixed pipe, the top threaded connection of fixed pipe has the knob, sheathed tube side surface is provided with five baffles, five the baffle is divided into regional one, regional two, regional three, regional four and regional five with the regional region around the sleeve pipe respectively, all be provided with the horizontal pole between the baffle of regional one and regional two both sides, two be provided with the constraint rope and connect the rope on the horizontal pole respectively, the bottom of connecting the rope is provided with the spring clamp, be provided with the frame plate between the baffle of regional three both sides, be provided with through-hole and draw-in groove on the frame plate respectively, be provided with the fixer on the frame plate, the bottom of fixer is provided with the card strip, the fixer passes through card strip and draw-in groove and frame plate swing, all be provided with vertical slide rail on the four regional both sides baffles, sliding connection has the baffle in the slide rail, the top of baffle inner wall is provided with loudspeaker, the inside swing joint of five regional food steamer trays, the food steamer includes the casket of bottom and the integrative apron in casket top, the top of casket is provided with the mesh, the inside of casket is provided with the temperature control stick.

Preferably, the base is circular, and the fixed pipe is located at the position of the circle center of the base.

Preferably, the five partition plates are identical in shape and size, and are distributed in an annular array by taking the axis of the fixed pipe as the array center.

Preferably, the binding rope is in an inverted Y shape.

Preferably, the shelf is located at the bisector position of the height of the partition.

Preferably, the baffle and the cover plate are both in an inverted L shape, and handles are arranged on the baffle and the food steamer.

(III) advantageous effects

The utility model provides a chronic unpredictable big, mouse liver depression spleen deficiency syndrome stress modeling instrument possesses following beneficial effect:

(1) the utility model discloses a set up the constraint rope, connect the rope, the spring clamp, the frame plate, the fixer, the baffle, loudspeaker, cage steamer tray and control by temperature change stick, the constraint rope is used for constraint stress experiment, it is used for the experiment of pressing from both sides the tail to connect rope and spring clamp, frame plate and fixer are used for the electric shock sole experiment, baffle and loudspeaker are used for the amazing experiment of noise, cage steamer tray and control by temperature change stick are used for heat stress experiment, make up into one set of whole special experimental facilities with several kinds of stress test tools, instrument preparation equipment and split around avoiding the experiment, simplify the experimental procedure, shorten the experimental time, improve the experimental efficiency, reach the effect that facilitates the use, it can't foresee a series of tool combination to test in the liver depression spleen deficiency syndrome stress experiment in advance to have solved current chronic, lead to whole process complicated loaded down with trivial details, bring.

(2) The utility model arranges the first region, the second region, the third region, the fourth region and the fifth region around the sleeve, so that the whole structure is compact and reasonable, and the occupied space is reduced; the knob is dismantled and assembled for sleeve pipe and baffle can with fixed pipe and base separation dismouting, conveniently clear up the disinfection, reach clean sanitary effect.

Drawings

Fig. 1 is a front view of the present invention;

fig. 2 is a top view of the present invention;

FIG. 3 is a top cross-sectional view taken along line A-A of FIG. 1 in accordance with the present invention;

FIG. 4 is a schematic view of the third structure of the area of the present invention;

fig. 5 is a top view of the frame plate of fig. 4 according to the present invention;

figure 6 is a side view of the holder of figure 4 in accordance with the present invention;

fig. 7 is a side view of the baffle of the present invention;

fig. 8 is a front sectional view of the food steamer of the present invention.

In the figure: 1. a base; 2. a fixed tube; 3. a sleeve; 4. a knob; 5. a partition plate; 6. a first area; 7. a second area; 8. a third area; 9. area four; 10. area five; 11. a cross bar; 12. a binding rope; 13. connecting ropes; 14. a spring clip; 15. a frame plate; 16. a through hole; 17. a card slot; 18. a holder; 19. clamping the strip; 20. a slide rail; 21. a baffle plate; 22. a horn; 23. a food steamer; 231. a box; 232. a cover plate; 233. mesh openings; 234. a temperature control rod; 24. a handle.

Detailed Description

The technical solutions in the embodiments of the present invention will be described clearly and completely with reference to the accompanying drawings in the embodiments of the present invention, and it is obvious that the described embodiments are only some embodiments of the present invention, not all embodiments. Based on the embodiments in the present invention, all other embodiments obtained by a person skilled in the art without creative work belong to the protection scope of the present invention.

As shown in fig. 1-8, the utility model provides a technical solution: a chronic unpredictable stress modeling tool for liver depression and spleen deficiency syndrome of mice comprises a base 1, a fixed pipe 2 is arranged on the base 1, the base 1 is fixedly connected with the fixed pipe 2, a sleeve 3 is movably sleeved on the surface of the fixed pipe 2, a knob 4 is unscrewed, a partition plate 5 and the sleeve 3 can rotate around the fixed pipe 2, the knob 4 is rotationally dismounted, the sleeve 3 and the partition plate 5 can be dismounted, the knob 4 is connected with the top of the fixed pipe 2 in a threaded manner, five partition plates 5 are arranged on the side surface of the sleeve 3, the five partition plates 5 divide the area around the sleeve 3 into a first area 6, a second area 7, a third area 8, a fourth area 9 and a fifth area 10 respectively, the first area 6, the second area 7, the third area 8, the fourth area 9 and the fifth area 10 are closed areas between two adjacent partition plates 5 and are respectively used for constraint, tail clamping, electric shock sole, noise stimulation and heat stress experiment, the partition boards 5 on two sides of the first area 6 and the second area 7 are respectively provided with a cross rod 11, the two cross rods 11 are respectively provided with a binding rope 12 and a connecting rope 13, the bottom of the connecting rope 13 is provided with a spring clamp 14, the partition boards 5 on two sides of the third area 8 are provided with frame boards 15, the frame boards 15 are respectively provided with a through hole 16 and a clamping groove 17, the through hole 16 is used for placing four limbs of a laboratory mouse, the fixer 18 is a transparent acrylic semicircular pipe and is used for fixing the laboratory mouse and is clamped and installed with the clamping groove 17 through a clamping strip 19, the frame boards 15 are provided with the fixer 18, the bottom of the fixer 18 is provided with the clamping strip 19, the fixer 18 is movably connected with the frame boards 15 through the clamping strip 19 and the clamping groove 17, the partition boards 5 on two sides of the fourth area 9 are respectively provided with a vertical slide rail 20, the slide rail 20 is connected with a baffle 21 in a sliding manner, the, loudspeaker 22 connecting wire is connected with audio output equipment, the inside swing joint of five 10 in region has food steamer 23, food steamer 23 includes casket 231 and the integrative apron 232 in casket 231 top of bottom, apron 232 is for having the transparent ya keli board of two faces in top and the side, the top of casket 231 is provided with mesh 233, the inside of casket 231 is provided with temperature control rod 234, temperature control rod 234 connects the water heating of power cord to casket 231 inside, the adjustable temperature of temperature control rod 234, whole experimentation is operated by professional, can not harm the laboratory mouse and also can not let the laboratory mouse escape and slide away.

As the utility model discloses a technical optimization scheme, base 1 is circular, and fixed pipe 2 is located base 1's centre of a circle position department, and regional 6, regional two 7, regional three 8, regional four 9 and regional five 10 encircle sleeve pipe 3 and set up, and overall structure is compact reasonable, reduces occupation space.

As a technical optimization scheme of the utility model, five baffles 5's shape and size is the same, and five baffles 5 use the axle center of fixed pipe 2 to be the annular array and distribute as the array center.

As a technical optimization scheme of the utility model, the constraint rope 12 is the shape of falling Y for tie the experiment with two forelimbs of laboratory mouse with anti-bundle to the back.

As a technical optimization scheme of the utility model, frame plate 15 is located the high bisector position department of baffle 5, will realize that laboratory mouse four limbs insert through-hole 16, cover fixer 18 above it, go into draw-in groove 17 through card 19 card and fix, shock to the laboratory mouse sole in frame plate 15 below.

As a technical optimization scheme of the utility model, the baffle 21 and the cover plate 232 are both in an inverted L shape, the handles 24 are arranged on the baffle 21 and the food steamer 23, the laboratory mouse is placed inside the region four 9, the baffle 21 is inserted downwards along the slide rail 20, so as to form a closed region with the region four 9, the signal input line of the loudspeaker 22 is connected with the audio output device, and the noise stimulation experiment is carried out; water is added through the meshes 233 to overflow the temperature control rod 234, the temperature control rod 234 is connected with a power supply and the temperature is set, after the specified temperature is reached, the laboratory mouse is placed on the box 231, and the food steamer 23 is pushed into the area five 10, so that the heat stress experiment can be carried out.

The working principle is as follows: five experiments are respectively carried out in five areas, the binding ropes 12 are arranged in the first area 6, and the two forelimbs of the experimental mouse are reversely bound to the back through the binding ropes 12 to carry out the binding experiment; the connecting rope 13 is positioned in the second area 7, and the tail of the experimental mouse is clamped by the spring clamp 14 to carry out tail clamping experiment; in the third area 8, four limbs of the laboratory mouse are placed in the through hole 16, the laboratory mouse is fixed through the fixing device 18, the laboratory mouse is clamped and installed with the clamping groove 17 through the clamping strip 19, and the foot bottom of the laboratory mouse is electrically shocked under the frame plate 15 to carry out an electric shock foot bottom experiment; when the laboratory mouse is placed in the region IV 9, the baffle plate 21 is inserted downwards along the slide rail 20, so that a closed region is formed by the baffle plate and the region IV 9, a signal input line of the loudspeaker 22 is connected with audio output equipment, and a noise stimulation experiment is carried out; water is added through the meshes 233 to overflow the temperature control rod 234, the temperature control rod 234 is connected with a power supply and is set to a temperature, after the specified temperature is reached, the laboratory mouse is placed on the box 231, and the food steamer 23 is pushed into the area five 10, so that the heat stress experiment can be carried out; after the experiment is finished, the fixer 18, the baffle 21 and the food steamer 23 are detached, the knob 4 is unscrewed, the sleeve 3 and the partition plate 5 are detached, and all the parts are cleaned, sterilized, dried, assembled and stored.

To sum up, the utility model discloses a set up constraint rope 12, connect rope 13, spring clamp 14, frame plate 15, fixer 18, baffle 21, loudspeaker 22, food steamer 23 and temperature control rod 234, solved and generally adopted a series of instrument combinations to test in the current chronic unpredictable liver depression spleen deficiency syndrome stress experiment, lead to whole process complicacy loaded down with trivial details, the problem of inconvenience is brought for the experiment.

It is noted that, herein, relational terms such as first and second, and the like may be used solely to distinguish one entity or action from another entity or action without necessarily requiring or implying any actual such relationship or order between such entities or actions. Also, the terms "comprises," "comprising," or any other variation thereof, are intended to cover a non-exclusive inclusion, such that a process, method, article, or apparatus that comprises a list of elements does not include only those elements but may include other elements not expressly listed or inherent to such process, method, article, or apparatus.

Although embodiments of the present invention have been shown and described, it will be appreciated by those skilled in the art that changes, modifications, substitutions and alterations can be made in these embodiments without departing from the principles and spirit of the invention, the scope of which is defined in the appended claims and their equivalents.

Claims

1. The utility model provides a chronic unpredictable big, mouse liver depression spleen deficiency syndrome stress modeling instrument, includes base (1), its characterized in that: the base (1) is provided with a fixed pipe (2), the surface of the fixed pipe (2) is movably sleeved with a sleeve (3), the top of the fixed pipe (2) is in threaded connection with a knob (4), the side surface of the sleeve (3) is provided with five clapboards (5), the five clapboards (5) divide the surrounding area of the sleeve (3) into a first area (6), a second area (7), a third area (8), a fourth area (9) and a fifth area (10) respectively, a cross rod (11) is arranged between the clapboards (5) at the two sides of the first area (6) and the second area (7), binding ropes (12) and connecting ropes (13) are arranged on the two cross rods (11) respectively, the bottom of the connecting ropes (13) is provided with a spring clamp (14), a frame plate (15) is arranged between the clapboards (5) at the two sides of the third area (8), and through holes (16) and clamping grooves (17) are arranged on the frame plate (15), be provided with fixer (18) on frame plate (15), the bottom of fixer (18) is provided with card strip (19), fixer (18) are through card strip (19) and draw-in groove (17) and frame plate (15) swing joint, all be provided with vertical slide rail (20) on four regional (9) both sides baffle (5), sliding connection has baffle (21) in slide rail (20), the top of baffle (21) inner wall is provided with loudspeaker (22), the inside swing joint of five regional (10) has cage steamer tray (23), cage steamer tray (23) are including casket (231) and the integrative apron (232) in casket (231) top of bottom, the top of casket (231) is provided with mesh (233), the inside of casket (231) is provided with temperature control stick (234).

2. The tool for modeling chronic unpredictable stress of liver depression and spleen deficiency in large and small mice according to claim 1, wherein the tool comprises: the base (1) is circular, and the fixed pipe (2) is located at the position of the circle center of the base (1).

3. The tool for modeling chronic unpredictable stress of liver depression and spleen deficiency in large and small mice according to claim 1, wherein the tool comprises: the five partition plates (5) are identical in shape and size, and the five partition plates (5) are distributed in an annular array by taking the axis of the fixed pipe (2) as the array center.

4. The tool for modeling chronic unpredictable stress of liver depression and spleen deficiency in large and small mice according to claim 1, wherein the tool comprises: the binding rope (12) is in an inverted Y shape.

5. The tool for modeling chronic unpredictable stress of liver depression and spleen deficiency in large and small mice according to claim 1, wherein the tool comprises: the frame plate (15) is positioned at the position of a bisector of the height of the partition plate (5).

6. The tool for modeling chronic unpredictable stress of liver depression and spleen deficiency in large and small mice according to claim 1, wherein the tool comprises: baffle (21) and apron (232) all are the shape of falling L, all be provided with handle (24) on baffle (21) and the food steamer (23).