CN213133117U - Coupling reaction kettle equipment - Google Patents
Coupling reaction kettle equipment Download PDFInfo
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- CN213133117U CN213133117U CN202021678046.6U CN202021678046U CN213133117U CN 213133117 U CN213133117 U CN 213133117U CN 202021678046 U CN202021678046 U CN 202021678046U CN 213133117 U CN213133117 U CN 213133117U
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Abstract
The utility model belongs to medicine production facility field relates to a coupling reaction kettle equipment. The utility model provides a disposable reaction bag uses with reation kettle is supporting in the coupling reation kettle equipment, once only stirs the reaction bag and throws promptly with the back, and not only fine prevention cross contamination makes the cauldron not with reaction medium direct contact moreover, has improved reation kettle's reuse rate, and reduction in production cost reduces the used back clean operation before with, has reduced the financial resources of verifying the maintenance and the input of manpower.
Description
Technical Field
The utility model relates to a coupling reaction kettle equipment belongs to medicine production facility field.
Background
In view of the complexity and specificity of ADC molecules, we need to continuously deepen understanding, and accumulating experience of the ADC molecules in terms of production process, quality control, non-clinical and clinical aspects, and further can reasonably formulate and standardize the superior and inferior standards based on the scientific and risk control strategies. In order to ensure the targeting property, purity and stability of ADC products, the traditional coupling device is a stainless steel reaction kettle or a glass reaction kettle, so that the accurate requirements of the coupling reaction on the reaction environments such as temperature, reaction time, rotating speed, pH and the like are met.
The coupling reactor used in the current ADC drug production is a stainless steel reaction kettle or a glass reaction kettle. Each ADC product corresponds to a specific monoclonal antibody and micromolecule, in order to ensure the quality of the ADC product, avoid cross contamination and ensure the cleanness of a coupling reaction apparatus, the coupling reaction of a new ADC product is carried out in a new stainless steel reaction kettle or a glass reaction kettle at present, so that the new reaction kettle is purchased, verified and maintained every time, the consumed manpower, material resources, financial resources and energy are more, and after the production of a batch of products is finished, the apparatus has low reusability and the production cost is higher.
SUMMERY OF THE UTILITY MODEL
ADC coupling reation kettle/jar reuse rate to among the prior art is low, and equipment purchase, verification, maintenance cause the higher problem of manufacturing cost with the maintenance, the utility model provides a coupling reation kettle equipment makes cauldron/jar not with reaction medium direct contact, can used repeatedly, improves the reactor utilization ratio.
The utility model discloses a realize above-mentioned purpose and the technical scheme who takes does:
the utility model provides a coupling reaction kettle equipment, includes the cauldron body and disposable reaction bag, its characterized in that: the disposable reaction bag sets up in the internal portion of cauldron, disposable reaction bag passes through detachable device with the cauldron body and is connected, disposable reaction bag upper end sets up the dog-house, is provided with agitator and first discharge gate in the bottom of disposable reaction bag, the bottom of the cauldron body is provided with the second discharge gate with the corresponding position of first discharge gate, and the lower extreme of first discharge gate is connected with the discharging pipe, and the discharging pipe is discharged reaction product through the second discharge gate.
Further, a temperature control system is also included.
Furthermore, the temperature control system comprises a jacket arranged between the kettle body and the disposable reaction bag, wherein the jacket is provided with a water inlet interface and a water return interface, and the water inlet interface is connected with the heat exchange cooling loop.
Furthermore, the temperature control system is also connected with a temperature probe.
Furthermore, the middle lower part of the kettle body is provided with a temperature monitoring hole, and the disposable reaction bag is sunken towards the inside at the position corresponding to the temperature monitoring hole so that the temperature probe can be inserted into the reaction system to detect the temperature.
Furthermore, a pH monitoring hole is also arranged at the top end of the disposable reaction bag.
Further, the device also comprises a pH monitoring system, and the pH monitoring system is connected with a pH probe.
Further, the device also comprises a pH monitoring system, and the pH monitoring system is connected with a pH probe.
The utility model has the advantages of it is following:
compared with the prior art, the beneficial effects of the utility model reside in that: the utility model provides a disposable reaction bag uses with reation kettle is supporting in the coupling reation kettle equipment, once only stirs the reaction bag and throws promptly with the back, and not only fine prevention cross contamination makes the cauldron not with reaction medium direct contact moreover, has improved reation kettle's reuse rate, and reduction in production cost reduces the used back clean operation before with, has reduced the financial resources of verifying the maintenance and the input of manpower.
Drawings
Fig. 1 is a perspective schematic view of the present invention;
wherein, 1-kettle body; 2-disposable reaction bag; 3-a detachable device; 4-a feeding port; 5-a stirrer; 6-a discharge pipe; 7-a temperature control system; 8-jacket; 9-water inlet interface; 10-a water return interface; 11-heat exchange cooling loop; 12-temperature probe; 13-temperature monitoring holes; 14-pH monitoring wells; 15-pH monitoring system; 16-pH probe; 17-valve.
Detailed Description
The following detailed description of the embodiments of the present invention will be made with reference to the accompanying drawings.
Example 1
As shown in figure 1, the coupling reaction kettle equipment comprises a kettle body (1) and a disposable reaction bag (2), wherein before the coupling reaction, the disposable reaction bag (2) is firstly installed inside the kettle body (1) through a detachable buckle (3). A feeding port (4) is arranged at the upper end of the disposable reaction bag (2), and reactants can be added into the disposable reaction bag (2) from the feeding port (4). The bottom of the disposable reaction bag (2) is provided with a stirrer (5) and a first discharge hole, the bottom of the kettle body (1) is provided with a second discharge hole at a position corresponding to the first discharge hole, the lower end of the first discharge hole is connected with a discharge pipe (6), and the discharge pipe (6) is provided with a valve (17). The coupling reaction kettle equipment also comprises a temperature control system (7), the temperature control system (7) comprises a jacket (8) arranged between the kettle body (1) and the disposable reaction bag (2), the jacket (8) is provided with a water inlet interface (9), a water return interface (10) and a heat exchange cooling loop (11), in addition, the temperature control system (7) is also connected with a temperature probe (12), in the reaction process, the temperature probe (12) is inserted into a temperature monitoring hole (13) of the kettle body (1), and the disposable reaction bag (2) which is cut at the corresponding position in the temperature monitoring hole (13) inwards forms a recess, so that the temperature probe (12) is directly contacted with the disposable reaction bag (2) to detect the temperature of the reaction system, the temperature detection result is fed back to the temperature control system (7), and then the temperature of the jacket (8) is adjusted through the heat exchange cooling loop (11), further adjusting the temperature of the reaction system in the disposable reaction bag (2). In addition, the coupling reaction kettle equipment also comprises a pH monitoring system (15), a pH probe (16) is connected on the pH monitoring system (15), and in the reaction process, the pH probe (16) can be inserted into a pH monitoring hole (14) of the disposable reaction bag (2) to detect the pH of the reaction system and feed back the pH to the pH monitoring system (15). After the reaction is finished, a valve (17) on the discharge pipe (6) is opened, and the discharge pipe (6) discharges a reaction product through the first discharge hole and the second discharge hole.
While the invention has been described with reference to a preferred embodiment, it will be understood by those skilled in the art that various changes in form and details may be made therein without departing from the spirit and scope of the invention. However, any simple modification, equivalent change and modification made to the above embodiments according to the technical substance of the present invention still belong to the protection scope of the technical solution of the present invention.
Claims (9)
1. The utility model provides a coupling reaction kettle equipment, includes the cauldron body and disposable reaction bag, its characterized in that: the disposable reaction bag sets up in the internal portion of cauldron, disposable reaction bag passes through detachable device with the cauldron body and is connected, disposable reaction bag upper end sets up the dog-house, is provided with agitator and first discharge gate in the bottom of disposable reaction bag, the bottom of the cauldron body is provided with the second discharge gate with the corresponding position of first discharge gate, and the lower extreme of first discharge gate is connected with the discharging pipe, and the discharging pipe is discharged reaction product through the second discharge gate.
2. The coupling reactor apparatus of claim 1, wherein: a temperature control system is also included.
3. The coupling reactor apparatus of claim 2, wherein: the temperature control system comprises a jacket arranged between the kettle body and the disposable reaction bag, a water inlet interface and a water return interface are arranged on the jacket, and the water inlet interface is connected with the heat exchange cooling loop.
4. The coupling reactor apparatus of claim 2, wherein: the temperature control system is also connected with a temperature probe.
5. The coupling reactor apparatus of claim 2, wherein: the middle-lower part of the kettle body is provided with a temperature monitoring hole, and the disposable reaction bag is sunken towards the inside at the position corresponding to the temperature monitoring hole so that the temperature probe can be inserted into the reaction system to detect the temperature.
6. The coupling reactor apparatus of claim 2, wherein: the top end of the disposable reaction bag is also provided with a pH monitoring hole.
7. The coupling reactor apparatus of claim 1 or 2, wherein: the pH monitoring system is connected with a pH probe.
8. The coupling reactor apparatus of claim 1 or 2, wherein: the discharge pipe is provided with a valve.
9. The coupling reactor apparatus of claim 1 or 2, wherein: the detachable device is a detachable buckle.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202021678046.6U CN213133117U (en) | 2020-08-13 | 2020-08-13 | Coupling reaction kettle equipment |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202021678046.6U CN213133117U (en) | 2020-08-13 | 2020-08-13 | Coupling reaction kettle equipment |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN213133117U true CN213133117U (en) | 2021-05-07 |
Family
ID=75737333
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202021678046.6U Active CN213133117U (en) | 2020-08-13 | 2020-08-13 | Coupling reaction kettle equipment |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN213133117U (en) |
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2020
- 2020-08-13 CN CN202021678046.6U patent/CN213133117U/en active Active
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