CN213049475U

CN213049475U - Crystallization device for producing omeprazole midbody

Info

Publication number: CN213049475U
Application number: CN202021764804.6U
Authority: CN
Inventors: 饶平平; 姚丽洁; 邱端红; 毛赛波
Original assignee: Fuzhou Sanhe Pharmachem Co ltd
Current assignee: Fuzhou Sanhe Pharmachem Co ltd
Priority date: 2020-08-21
Filing date: 2020-08-21
Publication date: 2021-04-27
Anticipated expiration: 2030-08-21

Abstract

The utility model relates to a medicine preparation technical field just discloses a crystallization device of omeprazole midbody production usefulness, comprising a base plate, the top fixedly connected with agitator tank of bottom plate, the top fixed mounting of agitator tank has the motor, the output shaft of motor passes through shaft coupling fixedly connected with dwang, the bottom of dwang is run through and is extended to the inside of agitator tank, the middle part cover of dwang is equipped with the turning block rather than fixed connection, the middle part cover of dwang is equipped with rather than fixed connection's first gear, the inside rotation of turning block is connected with two driven levers, two the bottom of driven lever all runs through and rotates the bottom that is connected to the turning block. The utility model discloses a, possess good stirring effect, can make the omeprazole magnesium salt abundant and even dissolution in the hydrosolvent, guarantee the crystallization effect, can carry out good saving to the crystallization simultaneously, guarantee crystal form, convenient to popularize and use.

Description

Crystallization device for producing omeprazole midbody

Technical Field

The utility model relates to a medicine preparation technical field specifically is a crystallization device of omeprazole midbody production usefulness.

Background

Omeprazole, mainly used for duodenal ulcer and tall-leaf wormwood syndrome, and also used for gastric ulcer and reflux esophagitis; the intravenous injection can be used for treating acute hemorrhage of peptic ulcer, and can be used together with amoxicillin and clindamycin or metronidazole and clarithromycin to kill helicobacter pylori.

The method for preparing the omeprazole crystal generally comprises the steps of dissolving the magnesium salt of omeprazole in a water mixed solvent with methanol, stirring for dissolving, stirring again, adding acetone, cooling, standing and precipitating the crystal.

SUMMERY OF THE UTILITY MODEL

Technical problem to be solved

The utility model provides a not enough to prior art, the utility model provides a crystallization device of omeprazole midbody production usefulness, possess good stirring effect, can make the omeprazole magnesium salt abundant and even dissolution in the hydrosolvent, guarantee crystallization effect, can carry out good saving to the crystallization simultaneously, guarantee advantages such as crystal form, current crystallization device has been solved, stirring effect is not good, can't make the omeprazole magnesium salt abundant and even dissolution in the hydrosolvent, influence crystallization effect, it is not good to preserve the crystallization after crystallization work is accomplished simultaneously, easily make the crystallization receive external factors such as temperature, form the problem of oiliness.

(II) technical scheme

For realizing above-mentioned good stirring effect that possesses, can make the omeprazole magnesium salt abundant and even dissolution in the hydrosolvent, guarantee the crystallization effect, can carry out good saving to the crystallization simultaneously, guarantee the purpose of crystal form, the utility model provides a following technical scheme: the utility model provides a crystallization device of omeprazole midbody production usefulness, includes the bottom plate, the top fixedly connected with agitator tank of bottom plate, the top fixed mounting of agitator tank has the motor, the output shaft of motor passes through shaft coupling fixedly connected with dwang, the bottom of dwang runs through and extends to the inside of agitator tank, the middle part cover of dwang is equipped with rather than fixed connection's turning block, the middle part cover of dwang is equipped with rather than fixed connection's first gear, the inside rotation of turning block is connected with two follower levers, two the bottom of follower lever all runs through and rotates the bottom of being connected to the turning block, two the middle part of follower lever all overlaps and is equipped with rather than fixed connection's second gear, two the outside of second gear all with first gear engagement, two the equal fixedly connected with in middle part of follower lever is the stirring leaf of equidistance range, the bottom of the rotating block is fixedly connected with two right-angle rods, one end of each right-angle rod, which is opposite to the other end of each right-angle rod, is fixedly connected with a stirring plate, the right side of the stirring box is fixedly provided with a water pump, the input end of the water pump is fixedly connected with a connecting pipe communicated with the water pump, the left end of the connecting pipe penetrates through and is fixedly connected to the inside of the stirring box, the output end of the water pump is fixedly connected with a delivery pipe communicated with the water pump, the top of the bottom plate is fixedly connected with a storage box, the right end of the delivery pipe penetrates through and is fixedly connected to the inside of the storage box, the top of the storage box is fixedly provided with a vacuum pump, the input end of the vacuum pump is fixedly connected with an exhaust pipe communicated with the vacuum pump, the bottom end of the exhaust pipe penetrates through and is fixedly connected to the inside of the storage box, the right end of the liquid discharge pipe penetrates through and is fixedly connected to the right side of the storage box, and a liquid inlet pipe communicated with the stirring box is fixedly connected to the top surface inside the stirring box.

Preferably, the front surface of the stirring box is fixedly provided with a control panel, and the bottom surface inside the stirring box is fixedly provided with a liquid level sensor.

Preferably, the inside fixedly connected with heat preservation of case, the bottom surface fixed mounting of the inside of case has the refrigerator, the right-hand member of contact tube, the bottom of exhaust tube and the left end of fluid-discharge tube all run through and fixedly connected to the inside of heat preservation, the left end of fluid-discharge tube and the right side contact of filter.

Preferably, a first electromagnetic valve is installed in the middle of the delivery pipe, and a second electromagnetic valve is fixedly installed in the middle of the liquid discharge pipe.

Preferably, the front of the storage box is hinged with a hinged door, the front of the hinged door is fixedly connected with a handle, and an observation window is arranged inside the hinged door.

Preferably, the back of the hinged door is fixedly connected with a sealing frame, and the back of the sealing frame is in contact with the storage box.

(III) advantageous effects

Compared with the prior art, the utility model provides a crystallization device of omeprazole midbody production usefulness possesses following beneficial effect:

1. this crystallization device of omeprazole midbody production usefulness, play the supporting role for whole device through the bottom plate, when needs carry out crystallization work, can utilize the feed liquor pipe to pour into the agitator tank with the water miscella that has the methyl alcohol, put into the omeprazole magnesium salt afterwards, utilize the motor to begin working, thereby make the dwang begin to rotate, drive the turning block afterwards and rotate, thereby make two right-angle poles drive two stirring boards and begin to move, utilize two second gears all with the first gear engagement at dwang middle part simultaneously, thereby make two second gears drive two driven levers and begin to rotate, thereby make two sets of stirring leaves take place the rotation in the rotatory while, thereby make the mixed effect more, make the solution effect of omeprazole magnesium salt in the aqueous solution better, utilize water pump work afterwards, thereby make the liquid of stirring completion have the connecting pipe to be taken out, discharge to the inside of saving box through the delivery pipe afterwards, after the completion that stews afterwards, utilize the fluid-discharge tube to get rid of liquid, utilize the filter to block fashioned crystal simultaneously, utilize the vacuum pump to drive the exhaust tube afterwards and bleed to the storage box to make the storage box interior be vacuum environment, thereby be convenient for to the save of crystallization.

2. This crystallization device of omeprazole midbody production usefulness, through level sensor's setting, be convenient for liquid in the agitator tank is taken out by the water pump when reaching the default to send instruction to control panel, control panel will stop water pump work afterwards, make first solenoid valve close afterwards, be convenient for handle liquid on next step, the usable control panel of user controls vacuum pump, second solenoid valve and refrigerator simultaneously.

3. This crystallization device of omeprazole midbody production usefulness, through the setting of refrigerator, be convenient for reduce the stability of preserving incasement portion, utilize the setting of heat preservation, reduce the condition that the incasement portion takes place the temperature loss, guarantee the preservation effect to the crystallization, reduce the crystallization and turn into the condition of oiliness because of temperature variation.

4. This crystallization device of omeprazole midbody production usefulness, through the setting of first solenoid valve and second solenoid valve, be convenient for control opening, the closure of contact tube and fluid-discharge tube, it is more convenient.

5. This crystallization device of omeprazole midbody production usefulness, through the setting of observation window, convenient to use person observes the inside condition, utilizes the setting of handle, and convenient to use person utilizes the handle to control hinged door, takes the transfer to the crystallization.

6. This crystallization device of omeprazole midbody production usefulness, through the setting of sealed frame, the gas tightness of case is preserved in effectual assurance, reduces the condition that takes place temperature variation.

Drawings

FIG. 1 is a schematic structural view of the present invention;

FIG. 2 is a front view of the structure of the present invention;

FIG. 3 is a schematic view of the hinged door of the present invention;

fig. 4 is an enlarged schematic view of a in fig. 1 of the present invention.

In the figure: 1. a base plate; 2. a stirring box; 3. an electric motor; 4. rotating the rod; 5. rotating the block; 6. a first gear; 7. a driven lever; 8. a second gear; 9. stirring blades; 10. a right-angle rod; 11. a stirring plate; 12. a water pump; 13. a connecting pipe; 14. a delivery pipe; 15. a storage box; 16. a vacuum pump; 17. an air exhaust pipe; 18. a filter plate; 19. a liquid discharge pipe; 20. a control panel; 21. a liquid level sensor; 22. a first solenoid valve; 23. a heat-insulating layer; 24. a refrigerator; 25. a liquid inlet pipe; 26. a second solenoid valve; 27. a hinged door; 28. a handle; 29. an observation window; 30. and (7) sealing the frame.

Detailed Description

The technical solutions in the embodiments of the present invention will be described clearly and completely with reference to the accompanying drawings in the embodiments of the present invention, and it is obvious that the described embodiments are only some embodiments of the present invention, not all embodiments. Based on the embodiments in the present invention, all other embodiments obtained by a person skilled in the art without creative work belong to the protection scope of the present invention.

Referring to fig. 1-4, a crystallization device for omeprazole intermediate production comprises a bottom plate 1, a stirring box 2 is fixedly connected to the top of the bottom plate 1, a motor 3 is fixedly installed at the top of the stirring box 2, an output shaft of the motor 3 is fixedly connected with a rotating rod 4 through a coupler, the bottom end of the rotating rod 4 penetrates and extends into the stirring box 2, a rotating block 5 fixedly connected with the rotating rod 4 is sleeved at the middle part of the rotating rod 4, a first gear 6 fixedly connected with the rotating rod 4 is sleeved at the middle part of the rotating rod 4, two driven rods 7 are rotatably connected inside the rotating block 5, the bottom ends of the two driven rods 7 penetrate and are rotatably connected to the bottom of the rotating block 5, second gears 8 fixedly connected with the middle parts of the two driven rods 7 are sleeved at the middle parts of the two driven rods 7, the outer sides of the two second gears 8 are respectively meshed with the first gear 6, stirring blades 9 which are equidistantly, the bottom of the rotating block 5 is fixedly connected with two right-angle rods 10, the back ends of the two right-angle rods 10 are fixedly connected with a stirring plate 11, the right side of the stirring box 2 is fixedly provided with a water pump 12, the input end of the water pump 12 is fixedly connected with a connecting pipe 13 communicated with the water pump 12, the left end of the connecting pipe 13 penetrates through and is fixedly connected to the inside of the stirring box 2, the output end of the water pump 12 is fixedly connected with a guide pipe 14 communicated with the water pump 12, the top of the bottom plate 1 is fixedly connected with a storage box 15, the right end of the guide pipe 14 penetrates through and is fixedly connected to the inside of the storage box 15, the top of the storage box 15 is fixedly provided with a vacuum pump 16, the input end of the vacuum pump 16 is fixedly connected with an air suction pipe 17 communicated with the vacuum pump, the bottom end of the air suction pipe 17 penetrates through and is fixedly connected to the inside of the, the right end of the liquid discharge pipe 19 penetrates and is fixedly connected to the right side of the storage box 15, the top surface inside the stirring box 2 is fixedly connected with a liquid inlet pipe 25 communicated with the stirring box 2, the bottom plate 1 plays a supporting role for the whole device, when crystallization work is required, a water mixed solvent with methanol can be poured into the stirring box 2 by the liquid inlet pipe 25, then an omeprazole magnesium salt is put in, the motor 3 is utilized to start work, the rotating rod 4 starts to rotate, the rotating block 5 is driven to rotate, the two right-angle rods 10 drive the two stirring plates 11 to start to move, meanwhile, the two second gears 8 are both meshed with the first gear 6 in the middle of the rotating rod 4, the two driven rods 7 are driven to start to rotate by the two second gears 8, the two groups of stirring blades 9 rotate while rotating, the mixing effect is better, and the dissolving effect of the omeprazole magnesium salt in the aqueous solution is better, utilize water pump 12 work afterwards to make the liquid that the stirring was accomplished have connecting pipe 13 to be taken out, discharge to the inside of preserving box 15 through eduction tube 14 afterwards, after the completion of stewing, utilize the fluid-discharge tube 19 to get rid of the liquid afterwards, utilize filter 18 to block fashioned crystal simultaneously, utilize vacuum pump 16 to drive exhaust tube 17 to preserve box 15 afterwards and bleed, thereby make the interior vacuum environment that is of preserving box 15, thereby be convenient for the saving to the crystallization.

Further, the front fixed mounting of agitator tank 2 has control panel 20, agitator tank 2 inside bottom surface fixed mounting has level sensor 21, setting through level sensor 21, be convenient for liquid in agitator tank 2 is taken out by water pump 12 when reaching the default, thereby send instruction to control panel 20, control panel 20 will stop water pump 12 work afterwards, make first solenoid valve 22 close afterwards, be convenient for handle liquid on next step, the usable control panel 20 of user is to vacuum pump 16 simultaneously, second solenoid valve 26 controls with refrigerator 24.

Further, the inside fixedly connected with heat preservation 23 of save case 15, the inside bottom surface fixed mounting of save case 15 has refrigerator 24, the right-hand member of eduction tube 14, the bottom of exhaust tube 17 all runs through and fixed connection to the inside of heat preservation 23 with the left end of fluid-discharge tube 19, the left end of fluid-discharge tube 19 and the right side contact of filter 18, setting through refrigerator 24, be convenient for reduce the inside stability of save case 15, utilize the setting of heat preservation 23, reduce the inside condition that takes place the temperature loss of save case 15, guarantee the save effect to the crystallization, reduce the crystallization and turn into the condition of oiliness because of temperature variation.

Furthermore, a first electromagnetic valve 22 is installed in the middle of the leading-out pipe 14, a second electromagnetic valve 26 is fixedly installed in the middle of the liquid discharge pipe 19, and the opening and closing of the leading-out pipe 14 and the liquid discharge pipe 19 are conveniently controlled through the arrangement of the first electromagnetic valve 22 and the second electromagnetic valve 26, so that the operation is more convenient.

Further, the front of the preservation box 15 is hinged with a hinged door 27, the front of the hinged door 27 is fixedly connected with a handle 28, an observation window 29 is arranged inside the hinged door 27, the user can observe the internal conditions through the arrangement of the observation window 29, the user can control the hinged door 27 through the handle 28 by utilizing the arrangement of the handle 28, and the crystals can be taken and transferred.

Further, the back of the hinged door 27 is fixedly connected with a sealing frame 30, the back of the sealing frame 30 is in contact with the storage box 15, and the sealing frame 30 is arranged, so that the air tightness of the storage box 15 can be effectively guaranteed, and the temperature change is reduced.

The utility model discloses the motor 3 model that uses can be Y90L-4, the water pump 12 model that uses can be WCB-50, the vacuum pump 16 model that uses can be PCV-2M, the control panel 20 model that uses can be SPC-STW-1810, the level sensor 21 model that uses can be GUY10, the first solenoid valve 22 that uses all can be ZC51-DB with second solenoid valve 26 model, the refrigerator 24 model that uses can be XD-2024, it is provided with rather than supporting control switch, and control switch's mounted position can be selected according to the in-service use needs.

The working principle is as follows: play the supporting role for whole device through bottom plate 1, when needing to carry out crystallization work, can utilize liquid inlet pipe 25 to pour into agitator tank 2 with the water miscella that has the methyl alcohol, put into the omeprazole magnesium salt afterwards, utilize motor 3 to begin work, thereby make dwang 4 begin to rotate, drive turning block 5 afterwards and rotate, thereby make two right-angle poles 10 drive two stirring boards 11 and begin to move, utilize two second gears 8 all to mesh with the first gear 6 at dwang 4 middle part simultaneously, thereby make two second gears 8 drive two driven levers 7 and begin to rotate, thereby make two sets of stirring leaf 9 take place the rotation in the rotatory while, thereby make the mixed effect more, make the dissolution effect of omeprazole magnesium salt in the aqueous solution better, utilize water pump 12 work afterwards, thereby make the liquid of stirring completion have connecting pipe 13 to be taken out, discharge to the inside of save case 15 through delivery pipe 14 afterwards, through the setting of the liquid level sensor 21, when the liquid in the stirring box 2 is pumped out by the water pump 12 to reach a preset value, an instruction is sent to the control panel 20, then the control panel 20 stops the work of the water pump 12, then the first electromagnetic valve 22 is closed, the setting of the first electromagnetic valve 22 is utilized, the opening and closing of the delivery pipe 14 are conveniently controlled, the next step of liquid treatment is more conveniently and conveniently carried out, meanwhile, a user can utilize the control panel 20 to control the vacuum pump 16, the second electromagnetic valve 26 and the refrigerator 24, then after the standing is completed, the second electromagnetic valve 26 is opened, the setting of the second electromagnetic valve 26 is utilized to conveniently control the opening and closing of the liquid discharge pipe 19, the liquid discharge pipe 19 is more conveniently utilized to discharge the liquid, meanwhile, the filter plate 18 is utilized to block the formed crystal, then the vacuum pump 16 is utilized to drive the air suction pipe 17 to pump the storage box 15, thereby the storage box 15 is in a vacuum environment, the crystal is convenient to be stored, the refrigerator 24 is used for reducing the stability in the storage box 15, the heat preservation layer 23 is used for reducing the temperature loss in the storage box 15, the air tightness of the storage box 15 can be effectively ensured according to the arrangement of the sealing frame 30, the storage effect on the crystal is ensured, the situation that the crystal is converted into oily matter due to temperature change is reduced, the observation window 29 is used for facilitating the user to observe the internal situation, the handle 28 is used for facilitating the user to control the hinged door 27 by using the handle 28, the crystal is taken and transferred, the whole device has good stirring effect, the omeprazole magnesium salt can be fully and uniformly dissolved in the hydrosolvent, the crystallization effect is ensured, meanwhile, the crystal can be well stored, and the crystal form is ensured, is convenient for popularization and use.

It is noted that, herein, relational terms such as first and second, and the like may be used solely to distinguish one entity or action from another entity or action without necessarily requiring or implying any actual such relationship or order between such entities or actions. Also, the terms "comprises," "comprising," or any other variation thereof, are intended to cover a non-exclusive inclusion, such that a process, method, article, or apparatus that comprises a list of elements does not include only those elements but may include other elements not expressly listed or inherent to such process, method, article, or apparatus. Without further limitation, an element defined by the phrase "comprising an … …" does not exclude the presence of other identical elements in a process, method, article, or apparatus that comprises the element.

Although embodiments of the present invention have been shown and described, it will be appreciated by those skilled in the art that changes, modifications, substitutions and alterations can be made in these embodiments without departing from the principles and spirit of the invention, the scope of which is defined in the appended claims and their equivalents.

Claims

1. A crystallization device for producing an omeprazole intermediate, which comprises a bottom plate (1), and is characterized in that: the top fixedly connected with agitator tank (2) of bottom plate (1), the top fixed mounting of agitator tank (2) has motor (3), the output shaft of motor (3) passes through shaft coupling fixedly connected with dwang (4), the bottom of dwang (4) is run through and is extended to the inside of agitator tank (2), the middle part cover of dwang (4) is equipped with turning block (5) rather than fixed connection, the middle part cover of dwang (4) is equipped with rather than fixed connection's first gear (6), the inside rotation of turning block (5) is connected with two driven levers (7), two the bottom of driven lever (7) all runs through and rotates the bottom of being connected to turning block (5), two the middle part of driven lever (7) all is equipped with rather than fixed connection's second gear (8), two the outside of second gear (8) all meshes with first gear (6), the middle parts of the two driven rods (7) are fixedly connected with stirring blades (9) which are arranged equidistantly, the bottom of the rotating block (5) is fixedly connected with two right-angle rods (10), the back ends of the two right-angle rods (10) are fixedly connected with a stirring plate (11), the right side of the stirring box (2) is fixedly provided with a water pump (12), the input end of the water pump (12) is fixedly connected with a connecting pipe (13) communicated with the water pump, the left end of the connecting pipe (13) penetrates through and is fixedly connected to the inside of the stirring box (2), the output end of the water pump (12) is fixedly connected with a guide pipe (14) communicated with the water pump, the top of the bottom plate (1) is fixedly connected with a storage box (15), the right end of the guide pipe (14) penetrates through and is fixedly connected to the inside of the storage box (15), and the top of the storage box (15) is fixedly provided, the vacuum pump is characterized in that an input end of the vacuum pump (16) is fixedly connected with an air exhaust pipe (17) communicated with the vacuum pump, the bottom end of the air exhaust pipe (17) penetrates through and is fixedly connected to the inside of the storage box (15), a filtering plate (18) is fixedly connected to the bottom surface of the inside of the storage box (15), a liquid discharge pipe (19) communicated with the right side of the inside of the storage box (15) is fixedly connected to the right side of the storage box (15), the right end of the liquid discharge pipe (19) penetrates through and is fixedly connected to the right side of the inside of the storage box (15), and a liquid inlet pipe (25) communicated with the top surface of the inside of.

2. A crystallization apparatus for omeprazole intermediate production according to claim 1, characterized in that: the front fixed mounting of agitator tank (2) has control panel (20), the inside bottom surface fixed mounting of agitator tank (2) has level sensor (21).

3. A crystallization apparatus for omeprazole intermediate production according to claim 1, characterized in that: the refrigerator is characterized in that a heat preservation layer (23) is fixedly connected to the inside of the storage box (15), a refrigerator (24) is fixedly mounted on the bottom surface of the inside of the storage box (15), the right end of the guide pipe (14), the bottom end of the suction pipe (17) and the left end of the liquid discharge pipe (19) penetrate through and are fixedly connected to the inside of the heat preservation layer (23), and the left end of the liquid discharge pipe (19) is in contact with the right side of the filter plate (18).

4. A crystallization apparatus for omeprazole intermediate production according to claim 1, characterized in that: the middle part of the leading-out pipe (14) is provided with a first electromagnetic valve (22), and the middle part of the liquid discharge pipe (19) is fixedly provided with a second electromagnetic valve (26).

5. A crystallization apparatus for omeprazole intermediate production according to claim 1, characterized in that: the front of the storage box (15) is hinged with a hinged door (27), the front of the hinged door (27) is fixedly connected with a handle (28), and an observation window (29) is arranged inside the hinged door (27).

6. A crystallization device for omeprazole intermediate production according to claim 5, characterized in that: the back of the hinged door (27) is fixedly connected with a sealing frame (30), and the back of the sealing frame (30) is in contact with the storage box (15).