CN220328092U

CN220328092U - Concentrated accurate purification device based on recombinant polypeptide medicine

Info

Publication number: CN220328092U
Application number: CN202321838926.9U
Authority: CN
Inventors: 于洋; 魏巍; 凌建群
Original assignee: Zhejiang Yingkang Biological Medicine Co ltd
Current assignee: Zhejiang Yingkang Biological Medicine Co ltd
Priority date: 2023-07-13
Filing date: 2023-07-13
Publication date: 2024-01-12
Anticipated expiration: 2033-07-13

Abstract

The utility model discloses a concentration and purification device based on recombinant polypeptide drugs, which comprises a drug tank, wherein the bottom of the drug tank is fixedly connected with a discharge pipe, one side of the discharge pipe is provided with an opening and closing mechanism, the inner wall of the drug tank is fixedly connected with a filter plate, the inner wall of the drug tank is fixedly connected with a symmetrical supporting plate, the surface of the supporting plate is fixedly connected with a filter screen cylinder, one side of the drug tank enables a control box to slide through a driving assembly, the inside of the drug tank is provided with a scraping mechanism, the scraping mechanism comprises a control motor arranged on the inner wall of the control box, and one end of an output shaft of the control motor is fixedly connected with a control rod through a coupling. This concentrated smart pure device based on recombinant polypeptide medicine has avoided filter screen section of thick bamboo and filter to be stopped up by impurity to influence filtration efficiency, make simultaneously filter screen section of thick bamboo and filter's washing operation more convenient.

Description

Concentrated accurate purification device based on recombinant polypeptide medicine

Technical Field

The utility model relates to the technical field of polypeptide drug production, in particular to a concentrated and refined device based on recombinant polypeptide drugs.

Background

Referring to China patent, a simple concentration device for polypeptide products (publication No. CN216418599U, publication No. 2022-5-3) rotates a protective cover through a handle and takes down the protective cover, polypeptide products needing to be concentrated are added through a charging port, the protective cover is conveyed into a plurality of filter cylinders under the action of an annular pipe, a driving motor, a driving bevel gear and a driven bevel gear drive a hollow shaft to enable the driving gear to rotate, a sleeve can drive a corresponding filter cylinder to rotate under the cooperation of the driving gear and the driven gears, meanwhile, the polypeptide products in the filter cylinder can be subjected to preliminary filtration under the cooperation of an annular filter screen, the filtered parts are conveyed to a filter plate position through a conveying pipe for secondary filtration along a supporting plate, multiple filtration of the polypeptide products can be realized under the action of a plurality of filter plates, then a lower discharge pipe and a side discharge pipe are opened through a control valve, so that the concentrated polypeptide products can be obtained, and portability of the device can be effectively improved through the handle.

Because the filter plate is fixedly installed, in the long-time use process, the condition that the filtering speed is reduced due to blockage, so that the working efficiency is influenced is caused, meanwhile, the inner surface of the filter cylinder is cleaned through the scraping plate, but due to the sealing property of the filter cylinder, larger substances scraped off the inner surface of the filter cylinder cannot be discharged and can remain in the filter cylinder, and after long-time work, the filter plate needs to be disassembled and washed, so that the working efficiency is influenced.

Disclosure of Invention

Aiming at the defects of the prior art, the utility model provides a concentrated and refined device based on recombinant polypeptide drugs, which solves the problems that in the existing concentrated and refined device of recombinant polypeptide drugs, a filter plate is easy to be blocked to cause slow filtering speed in the long-term use process, and the large matters scraped off the inner surface of a filter cylinder can not be discharged due to the sealing property of the filter cylinder, and can remain in the filter cylinder, and the filter plate needs to be disassembled and washed after long-term work, thereby influencing the working efficiency.

In order to achieve the above purpose, the utility model is realized by the following technical scheme: concentrated smart pure device based on recombinant polypeptide medicine, including the medicine jar, the bottom fixedly connected with exhaust pipe of medicine jar, one side of exhaust pipe is equipped with the mechanism that opens and shuts, the inner wall fixedly connected with filter of medicine jar, the inner wall fixedly connected with symmetrical backup pad of medicine jar, the fixed surface of backup pad is connected with the filter screen section of thick bamboo, one side of medicine jar makes the control box slide through drive assembly, the inside of medicine jar is equipped with scrapes material mechanism, including the control motor of installing at the control box inner wall in scraping material mechanism, the one end of the output shaft of control motor passes through shaft coupling fixedly connected with control rod, the surface of control rod is connected with the inside rotation of medicine jar, the fixed surface of control rod is connected with scrapes the material pole, the one end fixedly connected with closing plate of control rod, one side fixedly connected with cleaning rod of closing plate.

Preferably, a plurality of groups of liquid guide holes are formed in the surface of the supporting plate, and the surface of the scraping rod is attached to the inner surface of the filter screen cylinder.

Preferably, the driving assembly comprises a concave plate arranged on one side of the medicine tank, one side of the concave plate is fixedly connected with a driving air cylinder, one side of the driving air cylinder is in sliding connection with one side of the control box through a piston rod, and the inside of the concave plate is in sliding connection with the surface of the control box through a sliding rod.

Preferably, the opening and closing mechanism comprises an adjusting box arranged on one side of the discharge pipe, an opening and closing cylinder is fixedly connected to the inner wall of the adjusting box, a sliding toothed bar is connected to one side of the opening and closing cylinder in a sliding mode, the surface of the sliding toothed bar enables an opening and closing plate to rotate through a transmission assembly, and the surface of the opening and closing plate is attached to the inner surface of the discharge pipe.

Preferably, the transmission assembly comprises a transmission gear, a transmission rod is fixedly connected to the inside of the transmission gear, one end of the transmission rod is movably connected with the inner wall of the discharge pipe, the surface of the transmission rod is fixedly connected with the inside of the opening and closing plate, and the surface of the transmission gear is meshed with one side of the sliding toothed bar.

Preferably, the top fixedly connected with inlet pipe of medicine jar, the bottom fixedly connected with discharging pipe of medicine jar, the internally mounted of discharging pipe has the solenoid valve.

Advantageous effects

The utility model provides a concentration and purification device based on recombinant polypeptide drugs. Compared with the prior art, the method has the following beneficial effects:

(1) This concentrated smart pure device based on recombinant polypeptide medicine drives the piston rod through starting the actuating cylinder, scrape stock bar, closing plate and cleaning lever and slide towards the right side in step for the surface of cleaning lever is laminated mutually with one side of right side filter, scrapes the surface of stock bar and the interior surface of filter screen section of thick bamboo fully laminating this moment, and the through-hole of seting up on right side backup pad surface is opened, and rethread starts control motor and drives the control lever, scrapes stock bar and cleaning lever synchronous rotation, so will scrape the impurity of polypeptide medicine to filter screen section of thick bamboo interior surface and filter one side, through actuating cylinder and control motor's synchronous drive down, avoided filter screen section of thick bamboo and filter to be blocked by impurity, thereby influence filtration efficiency, make the cleaning operation of filter screen section of thick bamboo and filter more convenient simultaneously.

(2) This concentrated smart pure device based on recombinant polypeptide medicine drives the slip rack through starting the cylinder that opens and shuts and slides, and the slip of slip rack drives drive gear, transfer line and the synchronous rotation of board that opens and shuts to this opens the drain pipe for impurity and washing liquid water flow together, under the drive of cylinder that opens and shuts, make the operation that opens and shuts of drain pipe more convenient, make the drain pipe keep closing when concentrated smart pure of polypeptide medicine, open when wasing the medicine jar inside.

Drawings

FIG. 1 is a front view of the internal structure of the present utility model;

FIG. 2 is a right side view of the right side support plate of the present utility model;

FIG. 3 is a front view showing the internal structure of the regulating box of the present utility model;

fig. 4 is a top view showing the internal structure of the discharge pipe of the present utility model.

In the figure: 1-medicine tank, 2-discharge pipe, 3-opening and closing mechanism, 31-regulating box, 32-opening and closing cylinder, 33-sliding toothed bar, 34-transmission component, 341-transmission gear, 342-transmission bar, 35-opening and closing plate, 4-filter plate, 5-supporting plate, 6-filter screen cylinder, 7-driving component, 71-concave plate, 72-driving cylinder, 8-control box, 9-scraping mechanism, 91-control motor, 92 control bar, 93-scraping bar, 94-sealing plate, 95-cleaning bar, 10-liquid guiding hole, 11-feeding pipe and 12-discharge pipe.

Detailed Description

The following description of the embodiments of the present utility model will be made clearly and completely with reference to the accompanying drawings, in which it is apparent that the embodiments described are only some embodiments of the present utility model, but not all embodiments. All other embodiments, which can be made by those skilled in the art based on the embodiments of the utility model without making any inventive effort, are intended to be within the scope of the utility model.

Referring to fig. 1-4, the present utility model provides two technical solutions:

example 1

Concentrated smart pure device based on recombinant polypeptide medicine, including medicine jar 1, the bottom fixedly connected with exhaust pipe 2 of medicine jar 1, one side of exhaust pipe 2 is equipped with mechanism 3 that opens and shuts, the inner wall fixedly connected with filter 4 of medicine jar 1, the inner wall fixedly connected with symmetrical backup pad 5 of medicine jar 1, the fixed surface of backup pad 5 is connected with filter screen section of thick bamboo 6, one side of medicine jar 1 makes control box 8 slip through actuating assembly 7, the inside of medicine jar 1 is equipped with scrapes material mechanism 9, scrape the control motor 91 at control box 8 inner wall including installing in the material mechanism 9, control motor 91 is three-phase asynchronous motor, control motor 91 passes through electric wire and external circuit connection, the one end of the output shaft of control motor 91 passes through shaft coupling fixedly connected with control rod 92, the surface of control rod 92 is connected with the inside rotation of medicine jar 1, the fixed surface of control rod 92 is connected with scrapes the stock 93, the surface of scraping the filter screen 93 is laminated with the internal surface of filter screen section of thick bamboo 6, one end fixedly connected with closing plate 94, one side fixedly connected with cleaning rod 95 of closing plate 94, cleaning brush 95 is installed to one side of cleaning rod 95.

Example two

The concentrated and refined device based on the recombinant polypeptide medicine comprises a medicine tank 1, wherein the bottom of the medicine tank 1 is fixedly connected with a discharge pipe 2, one side of the discharge pipe 2 is provided with an opening and closing mechanism 3, the inner wall of the medicine tank 1 is fixedly connected with a filter plate 4, the inner wall of the medicine tank 1 is fixedly connected with a symmetrical supporting plate 5, the surface of the supporting plate 5 is fixedly connected with a filter screen cylinder 6, one side of the medicine tank 1 is provided with a control box 8 to slide through a driving component 7, the inside of the medicine tank 1 is provided with a scraping mechanism 9, the scraping mechanism 9 comprises a control motor 91 arranged on the inner wall of the control box 8, the control motor 91 is a three-phase asynchronous motor, the control motor 91 is connected with an external circuit through an electric wire, one end of an output shaft of the control motor 91 is fixedly connected with a control rod 92 through a coupler, the surface of the control rod 92 is rotationally connected with the inside of the medicine tank 1, the surface of the control rod 92 is fixedly connected with a scraping rod 93, the surface of the scraping rod 93 is attached to the inner surface of the filter screen cylinder 6, one end of the control rod 92 is fixedly connected with a sealing plate 94, one side of the sealing plate 94 is fixedly connected with a cleaning rod 95, one side of the cleaning rod 95 is provided with a cleaning brush, the cleaning rod is driven by the driving cylinder 72 to drive the piston rod, the scraping rod 93, the sealing plate 94 and the cleaning rod 95 to slide towards the right side synchronously, the surface of the cleaning rod 95 is attached to one side of the right side filter plate 4, at the moment, the surface of the scraping rod 93 is fully attached to the inner surface of the filter screen cylinder 6, through holes formed in the surface of the right side support plate 5 are opened, the control rod 92, the scraping rod 93 and the cleaning rod 95 are driven by the driving motor 91 to rotate synchronously, so that impurities of polypeptide medicines on the inner surface of the filter screen cylinder 6 and one side of the filter plate 4 are scraped, and synchronously driven by the driving cylinder 72 and the control motor 91, the filter screen cylinder 6 and the filter plate 4 are prevented from being blocked by impurities, so that the filtering efficiency is influenced, meanwhile, the cleaning operation of the filter screen cylinder 6 and the filter plate 4 is more convenient, a plurality of groups of liquid guide holes 10 are formed in the surface of the support plate 5, through holes are formed in the surfaces of the support plate 5 on the left side and the right side and are used for liquid circulation, a plurality of groups of liquid guide holes 10 are formed in the support plate 5 on the right side, the surface of the scraping rod 93 is attached to the inner surface of the filter screen cylinder 6, the driving assembly 7 comprises a concave plate 71 arranged on one side of the medicine tank 1, one side of the concave plate 71 is fixedly connected with a driving cylinder 72, the driving cylinder 72 is communicated with an external air source through an air pipe, one side of the driving cylinder 72 is in sliding connection with one side of the control box 8 through a piston rod, the inside of the concave plate 71 is in sliding connection with the surface of the control box 8 through a sliding rod, one end of the sliding rod is fixedly connected with the surface of the control box 8, the opening and closing mechanism 3 comprises an adjusting box 31 arranged on one side of the discharge pipe 2, the inner wall of the adjusting box 31 is fixedly connected with an opening and closing cylinder 32, the opening and closing cylinder 32 is connected with an external circuit through an air pipe, one side of the opening and closing cylinder 32 is slidingly connected with a sliding toothed bar 33, the surface of the sliding toothed bar 33 enables an opening and closing plate 35 to rotate through a transmission assembly 34, the surface of the opening and closing plate 35 is attached to the inner surface of the discharge pipe 2, the transmission assembly 34 comprises a transmission gear 341, the inside of the transmission gear 341 is fixedly connected with a transmission rod 342, the surface of the transmission rod 342 is rotationally connected with the inside of the adjusting box 31, one end of the transmission rod 342 is movably connected with the inner wall of the discharge pipe 2, the surface of the transmission rod 342 is fixedly connected with the inside of the opening and closing plate 35, the surface of the transmission gear 341 is meshed with one side of the sliding toothed bar 33, the top fixedly connected with inlet pipe 11 of medicine jar 1, the bottom fixedly connected with discharging pipe 12 of medicine jar 1, the internally mounted of discharging pipe 12 has the solenoid valve, the solenoid valve is prior art, be used for controlling the opening and shutting of discharging pipe 12, drive slip rack 33 through starting the cylinder that opens and shuts 32, the slip of slip rack 33 drives gear 341, gear 342 and the synchronous rotation of board 35 that opens and shuts, open exhaust pipe 2 with this, make impurity and washing liquid water together flow, under the drive of cylinder 32 that opens and shuts, make the operation that opens and shuts of exhaust pipe 2 more convenient, make exhaust pipe 2 keep closing when polypeptide medicine is concentrated accurate, open when wasing the inside medicine jar 1, the content that does not make detailed description in this specification all belongs to the prior art that the skilled person knows in the art simultaneously.

During operation, at first, through the inside of charge pipe 11 with polypeptide medicine injection medicine jar 1, polypeptide medicine flows to the inside of filter screen section of thick bamboo 6 through the through-hole of seting up on left side backup pad 5 surface, seal plate 94 laminates mutually with the through-hole of seting up on right side backup pad 5 surface this moment, polypeptide medicine filters the back through filter screen section of thick bamboo 6, liquid guiding hole 10 that seting up through right side backup pad 5 flows to the right side, the filter 4 on the rethread right side carries out secondary filtration, open discharging pipe 12 through the start-up solenoid valve this moment, thereby filter polypeptide medicine internal impurity, reach concentrated fine and pure effect, when the surface of the inside filter screen section of thick bamboo 6 of medicine jar 1 and filter 4 need be washd through charge pipe 11, the rethread drives piston rod through start-up actuating cylinder 72, scraper 93, closing plate 94 and cleaning rod 95 slide towards the right side in step, make the surface of cleaning rod 95 laminate mutually with one side of filter screen section of thick bamboo 4, the surface of thick bamboo 93 and the interior surface of filter screen section of thick bamboo 6 at this moment is fully laminated, the through-hole that the right side backup pad 5 surface was seting up is opened, rethread start-up control motor 91 drives control rod 92, scraper 93 and cleaning rod 95 and synchronous rotation, reach concentrated fine effect, the time need to wash liquid is carried out to the inside filter screen section of thick bamboo 6 and the filter screen 33 is driven to slide through the drive cylinder 33, and the drive the cleaning rod 33, and the drive cylinder 33 is opened and slide through the drive cylinder 33, and the end is slid to slide through the drive cylinder 33 and is made to slide through the filter 33.

It is noted that relational terms such as first and second, and the like are used solely to distinguish one entity or action from another entity or action without necessarily requiring or implying any actual such relationship or order between such entities or actions. Moreover, the terms "comprises," "comprising," or any other variation thereof, are intended to cover a non-exclusive inclusion, such that a process, method, article, or apparatus that comprises a list of elements does not include only those elements but may include other elements not expressly listed or inherent to such process, method, article, or apparatus.

Although embodiments of the present utility model have been shown and described, it will be understood by those skilled in the art that various changes, modifications, substitutions and alterations can be made therein without departing from the principles and spirit of the utility model, the scope of which is defined in the appended claims and their equivalents.

Claims

1. Concentrated smart pure device based on recombinant polypeptide medicine, including medicine jar (1), its characterized in that: the drug tank is characterized in that a discharge pipe (2) is fixedly connected to the bottom of the drug tank (1), an opening and closing mechanism (3) is arranged on one side of the discharge pipe (2), a filter plate (4) is fixedly connected to the inner wall of the drug tank (1), a symmetrical supporting plate (5) is fixedly connected to the inner wall of the drug tank (1), a filter screen cylinder (6) is fixedly connected to the surface of the supporting plate (5), a control box (8) is enabled to slide by a driving assembly (7) on one side of the drug tank (1), and a scraping mechanism (9) is arranged in the drug tank (1);

the scraping mechanism comprises a control motor (91) mounted on the inner wall of a control box (8), one end of an output shaft of the control motor (91) is fixedly connected with a control rod (92) through a coupler, the surface of the control rod (92) is rotationally connected with the inside of a medicine tank (1), the surface of the control rod (92) is fixedly connected with a scraping rod (93), one end of the control rod (92) is fixedly connected with a sealing plate (94), and one side of the sealing plate (94) is fixedly connected with a cleaning rod (95).

2. The recombinant polypeptide drug-based concentration and purification device according to claim 1, wherein: the surface of the supporting plate (5) on the right side is provided with a plurality of groups of liquid guide holes (10), and the surface of the scraping rod (93) is attached to the inner surface of the filter screen cylinder (6).

3. The recombinant polypeptide drug-based concentration and purification device according to claim 1, wherein: the driving assembly (7) comprises a concave plate (71) arranged on one side of the medicine tank (1), one side of the concave plate (71) is fixedly connected with a driving air cylinder (72), one side of the driving air cylinder (72) is in sliding connection with one side of the control box (8) through a piston rod, and the inside of the concave plate (71) is in sliding connection with the surface of the control box (8) through a sliding rod.

4. The recombinant polypeptide drug-based concentration and purification device according to claim 1, wherein: the opening and closing mechanism comprises an adjusting box (31) arranged on one side of a discharge pipe (2), an opening and closing cylinder (32) is fixedly connected to the inner wall of the adjusting box (31), a sliding toothed bar (33) is slidably connected to one side of the opening and closing cylinder (32), an opening and closing plate (35) is enabled to rotate through a transmission assembly (34) on the surface of the sliding toothed bar (33), and the surface of the opening and closing plate (35) is attached to the inner surface of the discharge pipe (2).

5. The recombinant polypeptide drug-based concentration and purification device according to claim 4, wherein: the novel automatic discharging device is characterized in that the transmission assembly (34) comprises a transmission gear (341), a transmission rod (342) is fixedly connected to the inside of the transmission gear (341), one end of the transmission rod (342) is movably connected with the inner wall of the discharging pipe (2), the surface of the transmission rod (342) is fixedly connected with the inside of the opening and closing plate (35), and the surface of the transmission gear (341) is meshed with one side of the sliding toothed rod (33).

6. The recombinant polypeptide drug-based concentration and purification device according to claim 1, wherein: the top fixedly connected with inlet pipe (11) of medicine jar (1), the bottom fixedly connected with discharging pipe (12) of medicine jar (1), the internally mounted of discharging pipe (12) has the solenoid valve.