CN212925056U

CN212925056U - Immune cell culture device

Info

Publication number: CN212925056U
Application number: CN202021423180.1U
Authority: CN
Inventors: 袁牧; 赵晓彤
Original assignee: Weihai Jiansheng Biotechnology Co ltd
Current assignee: Weihai Jiansheng Biotechnology Co ltd
Priority date: 2020-07-17
Filing date: 2020-07-17
Publication date: 2021-04-09
Anticipated expiration: 2030-07-17

Abstract

The utility model relates to the field of cell culture equipment, in particular to a culture device for immune cells, which comprises a culture box, a culture dish and a lifting device; the inside of the incubator is provided with a partition plate and a lifting base plate; the upper surface of lift base plate is provided with the spacing groove that is used for placing the culture dish, and the cross section of spacing groove is the rhombus structure, and the inside of spacing groove is provided with two holders of outer wall and spacing inslot wall structure adaptation, and two holders symmetry set up the left and right sides at the spacing groove, and all be provided with the arc centre gripping groove with culture dish radian adaptation in the one side that two holders are close to each other. The utility model discloses set up the lift base plate that has elevating gear in the inside of incubator to set up on the lift base plate and carried out spacing groove to the culture dish, set up the holder that carries out centre gripping and location to the culture dish in the inside of spacing groove, and set up the shock-absorbing structure of holder on the outer wall of holder, improved the stability of culture dish.

Description

Immune cell culture device

Technical Field

The utility model relates to a cell culture equipment field specifically is a culture apparatus for immune cell.

Background

The immune cells are commonly called as leucocytes, and comprise lymphocytes, various phagocytes and the like, and particularly refer to the lymphocytes which can recognize antigens and generate specific immune response. Lymphocytes are basic components of the immune system and widely distributed in vivo, and mainly T lymphocytes and B lymphocytes are stimulated by antigens to be activated, divide, proliferate and generate specific immune response. In addition to T lymphocytes and B lymphocytes, there are also K lymphocytes and NK lymphocytes, of four types. T lymphocytes are a versatile cell population. In addition to lymphocytes, cells involved in the immune response are cells of the plasma cell, granulocyte, mast cell, antigen presenting cell and mononuclear phagocyte systems.

With the development of scientific technology, the cell culture technology is more and more advanced, the traditional immune cell culture is usually cultured in a constant temperature box, but when the culture condition needs to be observed, the culture dish needs to be taken out, and a part of samples needs to be taken out for observation, so that the culture environment in the box body is easy to change; therefore, the prior art provides a culture device which is pushed up by an electric lifting structure, but the stability of the lifting device of the device is not enough, so that the culture dish is easy to shake in the moving process, the cell culture quality and progress are affected, and the technical improvement on the lifting device is needed.

SUMMERY OF THE UTILITY MODEL

An object of the utility model is to provide an immune cell culture apparatus to solve the problem that proposes among the above-mentioned background art.

In order to achieve the above object, the utility model provides a following technical scheme: a culture device for immune cells comprises an incubator, a culture dish and a lifting device; the inner part of the incubator is provided with a partition plate and a lifting base plate, the peripheral side walls of the lifting base plate are provided with lifting slide blocks, and the inner wall of the incubator is provided with a lifting chute for the lifting slide blocks to slide up and down; the lifting device comprises electric lifting rods arranged at the corners of the periphery of the bottom of the lifting base plate, and the bottoms of the electric lifting rods are connected with the partition plate; the upper surface of lift base plate is provided with the spacing groove that is used for placing the culture dish, and the cross section of spacing groove is the rhombus structure, and the inside of spacing groove is provided with two holders of outer wall and spacing inslot wall structure adaptation, and two holder symmetries set up the left and right sides at the spacing groove, and two holders all are provided with the arc centre gripping groove with culture dish radian adaptation in being close to each other, and the holder is provided with in the one side that is close to the spacing groove and is used for the absorbing centre gripping shock-absorbing structure of holder.

Preferably, a rubber gasket is arranged on the inner wall of the arc-shaped clamping groove.

Preferably, the clamping damping structure comprises a damping sliding rod fixedly arranged on the outer wall of the clamping piece.

Preferably, the end, far away from the holder, of the damping slide bar is arranged inside the lifting base plate in a sliding mode, a moving sliding groove for enabling the damping slide bar to slide left and right is formed in the lifting base plate, and a damping spring is sleeved on the damping slide bar.

Preferably, the bottom of the limiting groove is provided with a damping cushion block with a hemispherical structure.

Preferably, the center of the lifting slide block is provided with a guide rod in a penetrating manner, and the upper end and the lower end of the guide rod are fixedly connected with the upper inner wall and the lower inner wall of the lifting chute.

Compared with the prior art, the beneficial effects of the utility model are that:

the utility model discloses set up the lift base plate that has elevating gear in the inside of incubator to set up on the lift base plate and carried out spacing groove to the culture dish, set up the holder that carries out centre gripping and location to the culture dish in the inside of spacing groove, and set up the shock-absorbing structure of holder on the outer wall of holder, compare in the immune cell culture device of traditional over-and-under type, effectually improved this culture dish stability of going up and down in-process.

Drawings

Fig. 1 is a schematic view of the overall structure of the present invention;

fig. 2 is a top view of the lifting base plate of the present invention;

fig. 3 is a schematic view of the internal structure of the limiting groove of the present invention.

In the figure: 1. an incubator; 2. a culture dish; 3. a partition plate; 4. lifting the substrate; 5. a lifting slide block; 6. a lifting chute; 7. a guide bar; 8. an electric lifting rod; 9. a limiting groove; 10. a clamping member; 11. an arc-shaped clamping groove; 12. a rubber gasket; 13. a damping slide bar; 14. a moving chute; 15. a damping spring; 16. shock attenuation cushion.

Detailed Description

The technical solutions in the embodiments of the present invention will be described clearly and completely with reference to the accompanying drawings in the embodiments of the present invention, and it is obvious that the described embodiments are only some embodiments of the present invention, not all embodiments. Based on the embodiments in the present invention, all other embodiments obtained by a person skilled in the art without creative work belong to the protection scope of the present invention.

In the description of the present invention, it should be noted that the terms "vertical", "upper", "lower", "horizontal", and the like indicate orientations or positional relationships based on the orientations or positional relationships shown in the drawings, and are only for convenience of description and simplification of description, but do not indicate or imply that the device or element referred to must have a specific orientation, be constructed in a specific orientation, and be operated, and thus should not be construed as limiting the present invention.

In the description of the present invention, it should also be noted that, unless otherwise explicitly specified or limited, the terms "disposed," "mounted," "connected," and "connected" are to be construed broadly, e.g., as meaning either a fixed connection, a removable connection, or an integral connection; can be mechanically or electrically connected; they may be connected directly or indirectly through intervening media, or they may be interconnected between two elements. The specific meaning of the above terms in the present invention can be understood according to specific situations by those skilled in the art.

Referring to fig. 1-3, the present invention provides a technical solution: a culture device for immune cells comprises an incubator 1, a culture dish 2 and a lifting device; a partition plate 3 and a lifting base plate 4 are arranged in the incubator 1, lifting slide blocks 5 are arranged on the peripheral side walls of the lifting base plate 4, and a lifting chute 6 for the lifting slide blocks 5 to slide up and down is arranged on the inner wall of the incubator 1; the lifting device comprises electric lifting rods 8 arranged at the corners of the periphery of the bottom of the lifting base plate 4, and the bottoms of the electric lifting rods 8 are connected with the partition plate 3; the upper surface of lift base plate 4 is provided with spacing groove 9 that is used for placing culture dish 2, the cross section of spacing groove 9 is the rhombus structure, the inside of spacing groove 9 is provided with two holders 10 of outer wall and 9 inner wall structure adaptations of spacing groove, two holders 10 symmetry sets up the left and right sides at spacing groove 9, and two holders 10 all be provided with the arc centre gripping groove 11 with 2 radian adaptations of culture dish in the one side that are close to each other, holder 10 is provided with the centre gripping shock-absorbing structure that is used for holder 10 absorbing shock in the one side that is close to spacing groove 9.

Further, a rubber gasket 12 is arranged on the inner wall of the arc-shaped clamping groove 11.

Further, the clamping shock-absorbing structure comprises a shock-absorbing sliding rod 13 fixedly arranged on the outer wall of the clamping member 10.

Furthermore, one end of the damping slide rod 13, which is far away from the clamping member 10, is slidably disposed inside the lifting substrate 4, a moving chute 14 for allowing the damping slide rod 13 to slide left and right is disposed inside the lifting substrate 4, and a damping spring 15 is sleeved on the damping slide rod 13.

Further, the bottom of the limiting groove 9 is provided with a shock absorption cushion block 16 with a hemispherical structure.

Furthermore, a guide rod 7 penetrates through the center of the lifting slide block 5, and the upper end and the lower end of the guide rod 7 are fixedly connected with the upper inner wall and the lower inner wall of the lifting chute 6.

The working principle is as follows: in the process that the culture dish 2 on the lifting base plate 4 is pushed to move up and down by the electric lifting rod 8 in the use process of the culture box 1, the lifting base plate 4 drives the lifting slide block 5 to slide up and down in the lifting slide groove 6 along the direction of the guide rod 7, the guide rod 7 plays an effective guiding and limiting role on the lifting base plate 4, and the stability of the lifting base plate 4 is improved to a certain extent; the clamping pieces 10 at two sides in the limiting groove 9 play a role of stably clamping the culture dish 2 through the arc-shaped clamping groove 11. When the lifting base plate 4 shakes, the clamping piece 10 moves left and right, the damping slide rod 13 on the outer wall of the clamping piece moves in the moving slide groove 14 in a straight sliding mode in the same direction, and the damping spring 15 on the damping slide rod 13 and the rubber gasket 12 on the inner wall of the arc-shaped clamping groove 11 play an effective and damping role on the clamping piece 10 and the culture dish 2. The shock-absorbing cushion block 16 at the bottom of the culture dish 2 plays an effective longitudinal shock-absorbing role for the culture dish 2.

It is worth noting that: the electric lifting rod is controlled by the controller, and the controller matched equipment is common equipment, so that the electric lifting rod belongs to the existing mature technology, and the electric connection relation and the specific circuit structure are not repeated.

Although embodiments of the present invention have been shown and described, it will be appreciated by those skilled in the art that changes, modifications, substitutions and alterations can be made in these embodiments without departing from the principles and spirit of the invention, the scope of which is defined in the appended claims and their equivalents.

Claims

1. A culture apparatus for immune cells, characterized in that: comprises an incubator (1), a culture dish (2) and a lifting device; a partition plate (3) and a lifting base plate (4) are arranged in the incubator (1), lifting slide blocks (5) are arranged on the peripheral side walls of the lifting base plate (4), and a lifting slide groove (6) for the lifting slide blocks (5) to slide up and down is arranged on the inner wall of the incubator (1); the lifting device comprises electric lifting rods (8) arranged at the corners of the periphery of the bottom of the lifting base plate (4), and the bottoms of the electric lifting rods (8) are connected with the partition plate (3); the upper surface of lift base plate (4) is provided with spacing groove (9) that are used for placing culture dish (2), the cross section of spacing groove (9) is the rhombus structure, the inside of spacing groove (9) is provided with two holders (10) of outer wall and spacing groove (9) inner wall structure adaptation, two holders (10) symmetry set up the left and right sides in spacing groove (9), and all be provided with arc centre gripping groove (11) with culture dish (2) radian adaptation in the one side that two holders (10) are close to each other, holder (10) are provided with in the one side that is close to spacing groove (9) and are used for holder (10) absorbing centre gripping shock-absorbing structure.

2. The culture apparatus for an immune cell according to claim 1, wherein: and a rubber gasket (12) is arranged on the inner wall of the arc-shaped clamping groove (11).

3. The culture apparatus for an immune cell according to claim 1, wherein: the clamping damping structure comprises a damping sliding rod (13) fixedly arranged on the outer wall of the clamping piece (10).

4. The culture apparatus for an immune cell according to claim 3, wherein: the damping slide bar (13) is far away from one end of the clamping piece (10) and is arranged in the lifting base plate (4) in a sliding mode, a moving sliding groove (14) for enabling the damping slide bar (13) to slide left and right is formed in the lifting base plate (4), and a damping spring (15) is sleeved on the damping slide bar (13).

5. The culture apparatus for an immune cell according to claim 1, wherein: and the bottom of the limiting groove (9) is provided with a damping cushion block (16) with a hemispherical structure.

6. The culture apparatus for an immune cell according to claim 1, wherein: the center of the lifting slide block (5) is provided with a guide rod (7) in a penetrating mode, and the upper end and the lower end of the guide rod (7) are fixedly connected with the upper inner wall and the lower inner wall of the lifting chute (6).