CN212853470U - Medical detection equipment - Google Patents
Medical detection equipment Download PDFInfo
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- CN212853470U CN212853470U CN202020283172.5U CN202020283172U CN212853470U CN 212853470 U CN212853470 U CN 212853470U CN 202020283172 U CN202020283172 U CN 202020283172U CN 212853470 U CN212853470 U CN 212853470U
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- Measuring And Recording Apparatus For Diagnosis (AREA)
Abstract
The embodiment of the application provides a medical detection device, includes: a housing; the pressure measuring component is arranged on the outer wall of the shell and used for measuring the pressure of the environment outside the shell; and the concentration measuring component is arranged on the outer wall of the shell and used for measuring the concentration of the parameter to be measured in the external environment of the shell. The medical detection equipment in the embodiment of the application can realize the detection of various parameters (including pH value, occult blood concentration, pepsin concentration, trypsin concentration and the like) in the digestive tract by arranging the concentration measurement component, thereby improving the accuracy of the detection result of the medical detection equipment on the digestive tract. And the medical detection equipment can reduce medical detection procedures and reduce the number of required equipment in the detection process, thereby saving the cost.
Description
[ technical field ] A method for producing a semiconductor device
The application relates to the technical field of medical equipment, in particular to medical detection equipment.
[ background of the invention ]
With the acceleration of life rhythm, the life pressure of people is gradually increased, and digestive tract diseases become disease types which seriously affect the life quality of people due to the change of dietary structure. The diagnosis and treatment of digestive tract diseases are based on the accurate examination of physiological parameters and mucosal states of the digestive tract, and besides the state of the digestive tract mucosa, known parameters related to the health state of the digestive tract also comprise information such as digestive tract pressure, pH value and the like.
At present, an endoscope device is usually adopted to visually observe the alimentary canal mucosa, but due to the limitation of technical integration, the endoscope on the market can only observe the images of the alimentary canal mucosa, but cannot acquire other useful information in the alimentary canal. Therefore, the existing endoscope device has single function and cannot finish accurate detection of the digestive tract.
[ Utility model ] content
In view of this, the embodiment of the present application provides a medical detection apparatus, so as to solve the problem that in the prior art, an endoscope device has a single function and cannot perform accurate detection on the digestive tract.
The embodiment of the application provides medical detection equipment, including:
a housing;
the pressure measuring component is arranged on the outer wall of the shell and used for measuring the pressure of the environment outside the shell;
and the concentration measuring component is arranged on the outer wall of the shell and used for measuring the concentration of the parameter to be measured in the external environment of the shell.
In one possible design, the pressure measurement component includes a drive portion, an indicator portion, and an indicator;
the indicating part is provided with an indicating cavity, scales are arranged on the indicating part, and the indicating agent can correspond to different scales when flowing in the indicating cavity;
the driving part can drive the indicator to flow in the indicating cavity when being pressed.
In one possible design, the drive portion has a drive chamber in communication with the indicator chamber, and the indicator is contained within the drive chamber;
when the driving part is pressed, the driving cavity can deform and can press the indicator in the driving cavity into the indicating cavity.
In one possible design, the driving part comprises a pressure-sensitive membrane, and the pressure-sensitive membrane encloses the driving cavity;
when the pressure is applied, the pressure-sensitive film can deform towards the inside of the driving cavity, and when the pressure disappears, the pressure-sensitive film can restore to the original state.
In one possible design, the driving part and the indicating part are integrally formed, and each of the driving part and the indicating part comprises a pressure-sensitive film, and the pressure-sensitive film encloses the driving cavity and the indicating cavity;
the cross-sectional area of the drive chamber is greater than the cross-sectional area of the indicator chamber.
In one possible design, the driving part comprises a gas cavity and a liquid cavity, the gas cavity and the liquid cavity are separated by a driving plate, and the volumes of the gas cavity and the liquid cavity are adjusted by the movement of the driving plate;
the liquid cavity is provided with the indicator, the indicator in the liquid cavity can enter the indicator cavity, and the indicator in the indicator cavity can also enter the liquid cavity.
In one possible design, the indicator is one of methylene blue, beet red, vitamin B.
In one possible design, the concentration measuring part includes a polyion gel and a dye, and the dye is filled in the polyion gel;
the dye can change color when the concentration of the parameter to be measured is different.
In one possible design, the concentration measurement component includes one or more of a pH measurement component, a occult blood measurement component, a pepsin measurement component, a trypsin measurement component.
In one possible design, the dye of the pH measurement component is a pH sensitive dye that is capable of changing color in environments with different pH values.
In one possible design, hydrogen ions in the environment outside the housing can enter the pH measurement component through the polyion gel, and hydrogen ions in the pH measurement component can enter the environment outside the housing through the polyion gel;
the pH sensitive dye can bind to or separate from hydrogen ions to form a dynamic equilibrium.
In one possible design, the dye of the occult blood measurement component comprises a methylene blue dye that is capable of changing color in environments with different occult blood concentrations.
In one possible design, hemoglobin in the environment external to the housing is capable of binding and reacting with polyionic gel and methylene blue dye in the occult blood measurement component;
under the effect of hemoglobin, through redox reaction, the methylene blue dye can show the colour, and the concentration of hemoglobin is different, the colour that the methylene blue dye shows is different.
In one possible design, the dye of the pepsin measurement part comprises a bromophenol blue dye, which is capable of changing color in environments with different pepsin concentrations.
In one possible design, pepsin in the environment external to the housing is capable of binding to the polyion gel and the bromophenol blue dye in the pepsin measurement component;
the light scattering signals of the bound bromophenol blue dye change to show different colors, and the colors of the bromophenol blue dye are different when the concentration of pepsin is different.
In one possible design, the dye of the trypsin measuring part comprises a bromocresol purple dye, which is capable of changing color in environments with different trypsin concentrations.
In one possible design, trypsin in the environment external to the housing is capable of binding to polyionic gel and bromocresol purple dye in the trypsin measurement component;
the volume of the combined bromocresol purple dye is changed, the light scattering signal of the bromocresol purple dye is changed, different colors are displayed, and the colors of the bromocresol purple dye are different when the concentration of trypsin is different.
In one possible design, the pressure measuring parts and the concentration measuring parts are arranged on the outer wall of the shell in a partition mode or an alternate mode.
In one possible design, the medical testing device includes a plurality of the measurement members;
the ranges of the measurement components are not exactly the same, and/or the resolutions of the measurement components are not exactly the same.
In one possible design, the housing comprises a transparent portion;
the medical detection equipment further comprises an image component, wherein the image component is located in the inner cavity of the shell, and the image component can observe the environment outside the shell through the transparent part.
In one possible design, the housing includes first and second opposite end portions in an axial direction, each of the first and second end portions including the transparent portion;
the medical detection equipment comprises two image parts, wherein the two image parts are respectively arranged corresponding to the two transparent parts;
one of the concentration measuring member and the pressure measuring member is attached to an outer wall of the first end portion, and the other is attached to an outer wall of the second end portion; or,
the concentration measuring part and the pressure measuring part are both arranged on the outer wall of the first end part or the outer wall of the second end part; or,
the outer wall of the first end is provided with a first concentration measuring component and a first pressure measuring component, the outer wall of the second end is provided with a second concentration measuring component and a second pressure measuring component, the ranges of the first concentration measuring component and the second concentration measuring component are different, and the ranges of the first pressure measuring component and the second pressure measuring component are different.
In one possible design, the medical testing device further includes a data transmission assembly;
the image component comprises a lens and an image sensor, and the lens is connected with the image sensor through a mechanical structure and/or glue;
the image sensor is electrically connected or in signal connection with the data transmission assembly, and the lens is connected with the data transmission assembly through a mechanical structure and/or glue.
In one possible design, the lens is mounted in the inner cavity of the shell, and the lens has an effective imaging angle α 1, and the transparent part can cover the space where the effective imaging angle α 1 is located;
the image sensor is provided with a display image angle alpha 2, the transparent part can cover the space where the display image angle alpha 2 is located, and alpha 1 is larger than alpha 2;
the concentration measuring component and/or the pressure measuring component are/is arranged on the outer wall of the shell and positioned in a space between the effective imaging angle alpha 1 and the display image angle alpha 2;
the data transmission assembly is capable of reading data of the concentration measurement component and/or the pressure measurement component.
In one possible design, the lens is mounted in the inner cavity of the shell, and the lens has an effective imaging angle α 1, and the transparent part can cover the space where the effective imaging angle α 1 is located;
the image sensor is provided with a display image angle alpha 2, the transparent part can cover the space where the display image angle alpha 2 is located, and alpha 1 is larger than alpha 2;
the concentration measuring component and/or the pressure measuring component are/is arranged on the outer wall of the shell and positioned in the space occupied by the display image angle alpha 2;
the image sensor is capable of recognizing data of the concentration measuring part and/or the pressure measuring part.
In one possible design, the concentration measuring means and/or the pressure measuring means are located in the middle of the space occupied by the display image angle α 2.
In one possible design, the concentration measuring component is adhered to the outer wall of the shell through a transparent adhesive material;
the pressure measurement component is pasted on the outer wall of the shell through a transparent glue material.
In one possible design, the concentration measuring component is further adhered to the outer wall of the shell through edge sealing glue, and the edge sealing glue covers the outer edge of the measuring component.
In one possible design, the shell is a capsule-type structure;
the medical detection equipment is a capsule endoscope.
Therefore, the medical detection device in the embodiment of the present application can detect various parameters (including a pH value, a occult blood concentration, a pepsin concentration, a trypsin concentration, and the like) in the digestive tract by providing the concentration measurement component, so that the accuracy of the detection result of the medical detection device on the digestive tract can be improved. And the medical detection equipment can reduce medical detection procedures and reduce the number of required equipment in the detection process, thereby saving the cost.
[ description of the drawings ]
In order to more clearly illustrate the technical solutions of the embodiments of the present application, the drawings needed to be used in the embodiments will be briefly described below, and it is obvious that the drawings in the following description are only some embodiments of the present application, and it is obvious for those skilled in the art to obtain other drawings based on these drawings without creative efforts.
FIG. 1 is a schematic diagram of a medical testing device according to a first embodiment of the present disclosure;
FIG. 2 is an exploded view of FIG. 1;
FIG. 3 is a partial cross-sectional view of FIG. 1;
FIG. 4 is a schematic structural view of the pressure measurement unit of FIG. 1 in a first embodiment;
FIG. 5 is a sectional view taken along line A-A of FIG. 4;
FIG. 6 is a sectional view taken along line B-B of FIG. 4;
FIG. 7 is a schematic structural view of the pressure measurement unit of FIG. 1 in a second embodiment;
FIG. 8 is a schematic view of the concentration measurement section of FIG. 4;
FIG. 9 is a schematic view of the concentration measuring part of FIG. 4 connected to the housing;
FIG. 10 is a schematic diagram of a second embodiment of a medical testing device provided herein;
FIG. 11 is a schematic structural view of a medical testing device provided in the present application in a third embodiment;
FIG. 12 is a schematic view of a fourth embodiment of a medical testing device according to the present application;
FIG. 13 is a schematic structural view of a medical testing device provided in the present application in a fifth embodiment;
FIG. 14 is a top view of a medical testing device provided herein in a sixth embodiment;
FIG. 15 is a top view of a medical testing device provided herein in a seventh embodiment;
FIG. 16 is a top view of a medical testing device provided herein in an eighth embodiment;
FIG. 17 is a top view of a medical testing device provided herein in a ninth embodiment.
Reference numerals:
1-a shell;
11-a transparent portion;
12-upper shell;
13-a lower shell;
14-edge sealing glue;
2-a pressure measuring component;
21-a drive section;
211-a drive chamber;
212-a gas cavity;
213-a liquid chamber;
22-an indication part;
221-indicating cavity;
222-scale;
23-a drive plate;
24-a pressure sensitive film;
25-a binder;
3-a concentration measuring means;
31-a body portion;
32-glue material;
33-pH measuring means;
34-an occult blood measurement component;
35-pepsin measurement component;
36-trypsin measurement component;
4-an image component;
41-lens;
411-lens mount;
42-an image sensor;
43-lighting lamp;
5-a data transmission component;
51-a data acquisition processing module;
52-an antenna;
53-a battery;
6-infrared switch;
d1-effective imaging angle boundary;
d2-effective viewing angle boundary.
[ detailed description ] embodiments
For better understanding of the technical solutions of the present application, the following detailed descriptions of the embodiments of the present application are provided with reference to the accompanying drawings.
It should be understood that the embodiments described are only a few embodiments of the present application, and not all embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present application.
The terminology used in the embodiments of the present application is for the purpose of describing particular embodiments only and is not intended to be limiting of the application. As used in the examples of this application and the appended claims, the singular forms "a", "an", and "the" are intended to include the plural forms as well, unless the context clearly indicates otherwise.
It should be understood that the term "and/or" as used herein is merely one type of association that describes an associated object, meaning that three relationships may exist, e.g., a and/or B may mean: a exists alone, A and B exist simultaneously, and B exists alone. In addition, the character "/" herein generally indicates that the former and latter related objects are in an "or" relationship.
It should be noted that the terms "upper", "lower", "left", "right", and the like used in the embodiments of the present application are described in terms of the angles shown in the drawings, and should not be construed as limiting the embodiments of the present application. In addition, in this context, it will also be understood that when an element is referred to as being "on" or "under" another element, it can be directly on "or" under "the other element or be indirectly on" or "under" the other element via an intermediate element.
In the field of medical equipment, when measuring the pressure of the digestive tract of a human body, an MEMS (Micro-Electro-Mechanical System) pressure sensor is generally used, and the pressure sensor is manufactured by using conventional Micro-electronic and Micro-machining technologies, and in order to satisfy biocompatibility with the human body, the pressure sensor needs to be packaged secondarily when measuring the pressure of the digestive tract of the human body. In addition, sensors developed by semiconductor technology are generally used to measure the concentration of various parameters of the human digestive tract.
The endoscope device, the micro-electro-mechanical pressure sensor and the semiconductor sensor are all used for detecting the digestive tract of a human body, theoretically, the three parts can be integrated, but at present, no process capable of integrating the three parts exists, or in the existing process, equipment formed by integrating the three parts is low in reliability and high in integrated process cost. Based on this, no device for simultaneously detecting images, pressure and concentration information of the digestive tract mucosa has been reported so far, which leads to complicated detection procedures of the human digestive tract and more required detection devices.
The medical detection equipment in the application can observe the health condition of the mucous membrane of the digestive tract and can acquire the pressure and concentration information of the digestive tract, namely the medical detection equipment integrates the endoscope device, the concentration measurement component and the pressure measurement component, meanwhile, the integration process of the three components can be simplified and the integration cost can be reduced by changing the structures of the concentration measurement component and the pressure measurement component, and the specific structure of the medical detection equipment is as follows.
The embodiment of the application provides a medical detection device, as shown in fig. 1 and fig. 2, the medical detection device includes a housing 1, a pressure measurement component 2 and a concentration measurement component 3, wherein the housing 1 may further include an upper shell 12 and a lower shell 13, and the upper shell 12 and the lower shell 13 are fixedly connected and enclose an inner cavity of the housing 1; the concentration measuring part 3 is installed at an outer wall of the housing 1 for measuring a parameter of an external environment of the housing 1. When the medical detection equipment is used for detecting the digestive tract, the medical detection equipment can be used for detecting parameters of the digestive tract, such as pH value, occult blood concentration, pepsin concentration, trypsin concentration and the like. The pressure measuring part 2 is mounted on the outer wall of the housing 1, wherein the pressure measuring part 2 is used for measuring the pressure of the external environment to which the housing 1 is exposed. For example, when the medical test device is placed in the digestive tract of a human body, the external environment of the housing 1 refers to the digestive tract of the human body, and at this time, the pressure measuring part 2 is used to measure the pressure in the digestive tract of the human body.
Therefore, the medical detection apparatus in the embodiment of the present application can detect various parameters (including a pH value, a occult blood concentration, a pepsin concentration, a trypsin concentration, and the like) in the digestive tract by providing the concentration measuring unit 3, and can improve the accuracy of the detection result of the medical detection apparatus on the digestive tract, and can measure the pressure in the digestive tract by providing the pressure measuring unit 2, thereby further improving the accuracy of the detection result. And the medical detection equipment can reduce medical detection procedures and reduce the number of required equipment in the detection process, thereby saving the cost.
Specifically, as shown in fig. 4 and 7, the pressure measuring part 2 includes a driving part 21, an indicating part 22, and an indicator, wherein the indicating part 22 has an indicating cavity 221 inside, the indicator can flow in the indicating cavity 221, and the indicating part 22 is further provided with a scale 222, which can correspond to different scales when the indicator flows in the indicating cavity 221. Meanwhile, when the pressure measurement component 2 is subjected to the pressure of the external environment (e.g., the pressure of the digestive tract of a human body), the driving portion 21 can drive the indicator to flow in the indicating cavity 221, and the scale 222 corresponding to the indicator during the flow process can represent the pressure to which the pressure measurement component 2 is subjected.
In the indicating portion 22, after the scale 222 is provided, a reference point, that is, a zero point of the degree 222 is provided, and when the indicator points to the zero point position, it indicates that the pressure applied to the pressure measuring member 2 is approximately zero, and when the indicator points to the scale 222 larger than zero, it indicates that the pressure measuring member 2 is applied to the external pressure (for example, the pressure applied to the digestive tract of the human body), and the larger the value of the scale 222 pointed by the indicator is, the larger the external pressure applied to the pressure measuring member 2 is.
More specifically, as shown in FIGS. 4-6, in the first embodiment, the driving portion 21 has a driving chamber 211 communicated with an indicating chamber 221, the driving chamber 211 has an indicator therein, and when the pressure applied to the pressure measuring unit 2 approaches zero, the indicator is entirely located in the driving chamber 211 and fills the driving chamber 211, and at this time, the indicator points to the zero point in the indicating portion 22. When the pressure measuring component 2 is subjected to a pressure greater than zero, the pressure can act on the driving part 21, and under the action of the pressure, the driving cavity 211 can deform towards the inside thereof, and the indicator in the driving cavity 211 can be pressed into the indicating cavity 221 in the deformation process, so that the indicator can point to the scale 222 greater than zero, and the greater the pressure, the more the indicator enters the indicating cavity 221, and the larger the scale 222.
Of course, the position of the scale 222 in the indicating portion 22 can also be adjusted according to the indicator flow rate inside the pressure measuring component 2, and in order to ensure high measurement accuracy of the pressure measuring component 2, the indicator in the inner cavity can at least fill the driving cavity 211.
On the other hand, the measurement sensitivity of the pressure measuring part 2 can be adjusted by changing the sectional area of the indicating chamber 211, and the sensitivity is higher and the accuracy is higher as the sectional area of the indicating chamber 211 is smaller. Meanwhile, the range of the pressure measuring part 2 can also be adjusted by changing the length of the indicating chamber 211 in the indicator flow direction (the length of the indicating portion 22), which is larger as the length of the indicating portion 22 is longer.
In this embodiment, as shown in fig. 5 and 6, the driving portion 21 includes a pressure-sensitive film 24, the pressure-sensitive film 24 surrounds the driving cavity 211, and the pressure-sensitive film 24 may be one or more of a polyester film and a polyamide film, the pressure-sensitive film 24 can be deformed toward the inside of the driving cavity 211 when receiving an external pressure, and the pressure-sensitive film 24 can be restored to an original state when the pressure disappears, so that the driving portion 21 made of the pressure-sensitive film 24 enables the pressure measuring component 2 to have high sensitivity and to perform multiple measurements.
Specifically, the driving chamber 211 may be completely surrounded by the pressure-sensitive films 24, as shown in fig. 5 and 6, the driving portion 21 may also include a plurality of pressure-sensitive films 24, and the pressure-sensitive films 24 are connected by an adhesive 25, wherein the adhesive 25 may be one or more of acrylates and epoxies.
More specifically, as shown in fig. 4, the driving portion 21 and the indicating portion 22 are integrally formed, and the driving portion 21 and the indicating portion 22 both include the pressure-sensitive film 24, so that the pressure-sensitive film 24 encloses the driving cavity 211 and the indicating cavity 221, at this time, due to the property of the pressure-sensitive film 24, the driving cavity 211 can be deformed after the driving portion 21 is stressed, and the indicating cavity 221 can also be deformed after the indicating portion 22 is stressed, but the accuracy of the measurement result can be affected after the indicating cavity 221 is deformed.
In order to solve the technical problem, in the embodiment, as shown in fig. 4, the sectional area of the driving cavity 211 is larger than the sectional area of the indication cavity 221, and the sectional area of the driving cavity 211 is 2-10 times of the sectional area of the indication cavity 221, when the driving part 21 and the indication part 22 are stressed, the driving cavity 211 can deform, and the deformation amount of the indication cavity 221 is small, so that the pressure measurement component 2 can be ensured to have high sensitivity and measurement accuracy.
Of course, in order to prevent the indicating chamber 221 from deforming when being stressed and affecting the measuring accuracy, the indicating part 22 may be configured to have high strength and rigidity, and is not easily deformed when being stressed. However, in the present embodiment, the driving portion 21 and the indicating portion 22 which are integrally formed have advantages of simple structure and convenient processing, and when the pressure measuring component 2 is used in a medical detection device, the pressure sensitive membrane 24 with low rigidity has little damage to a human body and has high biocompatibility with the human body, thereby improving safety of the pressure measuring component 2.
In the embodiment shown in fig. 7, the pressure measuring unit 2 includes a driving unit 21, an indicating unit 22 and a driving plate 23, wherein the driving unit 21 includes a gas chamber 212 and a liquid chamber 213, the gas chamber 212 is used for containing gas (the gas is nontoxic gas, and the pressure of the gas is within a range that can be tolerated by human body), the liquid chamber 213 is used for containing liquid (such as indicator), and the gas chamber 212 and the liquid chamber 213 are separated by the driving plate 23, and the driving plate 23 can move, so as to adjust the volumes of the gas chamber 212 and the liquid chamber 213. The indicating part 22 includes an indicating chamber 221 communicating with the liquid chamber 213, that is, the liquid in the liquid chamber 213 can enter the indicating chamber 221, and the liquid in the indicating chamber 221 can also enter the liquid chamber 213; the indication portion 22 is further provided with a scale 222 for indicating the scale.
When the external pressure applied to the gas cavity 212 of the pressure measurement component 2 increases, the side wall of the gas cavity 212 can be pressed, so that the volume of the gas cavity 212 decreases, the pressure inside the gas cavity increases, the driving plate 23 is pushed to move towards the liquid cavity 213, the volume of the liquid cavity 213 is decreased, the liquid in the liquid cavity 213 is pushed to enter the indication cavity 221, the scale displayed by the indication part 22 is increased, the pressure to be measured is increased, and the specific numerical value can be displayed through the scale 222. When the external pressure applied to the gas cavity 212 of the pressure measuring part 2 is reduced (less than the pressure of the liquid in the liquid cavity 213 on the gas cavity 212), the liquid in the liquid cavity 213 can drive the driving plate 23 to move towards the gas cavity 212, the volume of the liquid cavity 213 is increased, so that the liquid in the indicating cavity 221 enters the liquid cavity 213, the scale displayed by the indicating part 22 is reduced, the pressure to be measured is reduced, and the specific numerical value can be displayed through the scale 222. In the above embodiments, the indicator may be one of methylene blue, beet red and vitamin B, wherein the methylene blue is dissolved in water to form a blue solution, the beet red is dissolved in water to form a red solution, and the vitamin B is dissolved in water to form a yellow solution, so that all of the above three substances can improve the identifiability of the indicator in the indicating chamber 221, and the methylene blue solution is preferably used to avoid the color approaching to the color inside the human body. Meanwhile, the scale 222 of the indicating part 22 may be white, so that it can be easily distinguished from the indicator.
Further, the medical detection device can comprise a plurality of pressure measurement components 2, and the ranges of the pressure measurement components 2 are not completely the same, at this time, the pressure measurement components 2 with different ranges can meet the measurement of different pressure ranges, and the accuracy of the detection result is improved.
Meanwhile, when the medical detection equipment comprises a plurality of pressure measurement components 2, the condition that pressure measurement cannot be carried out or the measurement result is inaccurate due to the fact that a single pressure measurement component 2 fails can be avoided. The pressure measurement component 2 is attached to the outer surface of the shell 1 through a transparent adhesive material, the transparent adhesive has biocompatibility, and the transparent adhesive can be, but is not limited to, medical-grade UV adhesive, medical instant adhesive or medical adhesive.
In one possible design, the concentration measuring component 3 in the present embodiment may include one or more of a pH measuring component 33, an occult blood measuring component 34, a pepsin measuring component 35, and a trypsin measuring component 36, wherein the pH measuring component 33 can be used to measure the pH of the environment external to the housing 1 (e.g., the alimentary tract), the occult blood measuring component 34 can be used to measure the presence and concentration of occult blood in the environment external to the housing 1 (e.g., the alimentary tract), the pepsin measuring component 35 is used to measure the concentration of pepsin in the environment external to the housing 1 (e.g., the alimentary tract), and the trypsin measuring component 36 is used to measure the concentration of trypsin in the environment external to the housing 1 (e.g., the alimentary tract).
Therefore, in the present embodiment, the various concentration measuring means 3 can measure various parameters of the digestive tract, thereby improving the accuracy of the detection result of the medical detection device.
It should be noted that the medical detection apparatus in the embodiment of the present application does not necessarily include the four concentration measurement components 3, and may include only one or any combination thereof.
Specifically, as shown in fig. 8, the concentration measuring component 3 may include a main body 31 and a rubber 32, wherein the rubber 32 is a transparent rubber and has biocompatibility, so that the main body 31 of the concentration measuring component 3 can be adhered to the housing 1 of the medical detection device through the rubber 32. The adhesive material 32 may be a transparent adhesive tape, and is adhered to the transparent portion 11 of the housing 1. The transparent back adhesive may be, but is not limited to, a medical grade UV adhesive, a medical flash adhesive, or a medical back adhesive.
More specifically, as shown in fig. 9, the body 31 of the concentration measuring component 3 and the outer wall of the housing 1 are also connected by a sealing glue 14, wherein the sealing glue 14 is disposed on the outer edge of the body 31, so that the concentration measuring component 3 and the housing 1 are adhered by the sealing glue 14. The edge sealing adhesive 14 may be, but is not limited to, a medical-grade UV adhesive, a medical flash adhesive, or a medical back adhesive.
In this embodiment, when the outer edge of the concentration measurement component 3 is connected to the housing 1 through the edge sealing adhesive 14, the connection reliability between the concentration measurement component 3 and the housing 1 can be further improved, and the risk that the concentration measurement component 3 falls off from the housing 1 in the use and installation processes is reduced.
Specifically, the concentration measuring part 3 may include a polyion gel and a dye, which is capable of changing color. The concentration measuring component 3 may be a thin film structure, and the shape thereof may be any shape such as a circle, a square, a polygon, etc., and the specific shape of the concentration measuring component 3 is not limited in the present application.
In one possible design, the body portion 31 of the concentration measuring part 3 includes polyion gel and dye, wherein the dye can change color, the polyion gel is a solid substance formed by cross-linking polymerization of polymer, and the dye is filled in the polyion gel, and the polyion gel and the dye ions have strong ionic interaction, so that the dye ions can be kept in the polyion gel.
The polyion gel contains an ion exchange membrane structure, and the ion exchange membrane is a polymer membrane which contains ionic groups and has selective permeability to ions in a solution. Meanwhile, when the concentration measuring part 3 is located in a solution environment (e.g., the digestive tract of a human body), ions (e.g., hydrogen ions) of a substance to be measured in the solution can enter the polyion gel and combine with the dye in the polyion gel to discolor the dye. In addition, in the concentration measuring part 3, the concentration of ions (for example, hydrogen ions) of the substance to be measured in the solution is the same as the concentration of ions (for example, hydrogen ions) of the substance to be detected in the polyion gel, and when the concentration of ions (for example, hydrogen ions) of the substance to be detected in the solution increases, the ions (for example, hydrogen ions) of the substance to be measured bound to the dye can diffuse into the polyion gel, thereby increasing the concentration of ions (for example, hydrogen ions) of the substance to be measured, corresponding to the concentration of one substance to be measured (for example, the concentration of hydrogen ions, that is, the; when the concentration of ions (e.g., hydrogen ions) of the substance to be measured in the solution decreases, the ions (e.g., hydrogen ions) of the substance to be measured in the polyion gel can diffuse into the solution, thereby decreasing the concentration of ions (e.g., hydrogen ions) of the substance to be measured bound to the dye, corresponding to the concentration of another substance to be measured (e.g., the concentration of hydrogen ions, i.e., the pH of the solution).
Therefore, in the present embodiment, the dye in the concentration measuring part 3 can be bonded to or separated from the ions (for example, hydrogen ions) of the substance to be measured to form a dynamic equilibrium, and continuous measurement of the concentration of the substance to be measured can be realized.
Based on this, in the present embodiment, the concentration measuring component 3 including the polyion gel and the dye can be conveniently integrated (e.g. adhered) with the medical detection device (e.g. capsule endoscope), and the integrated concentration measuring component is compatible with the hardware of the medical detection device, and does not need to perform secondary packaging, and only needs to modify related software to perform ph measurement while performing endoscopy, so as to improve the detection accuracy. Meanwhile, by additionally arranging the polyion gel, ions of the substance to be detected in the solution can penetrate through the polyion gel and be combined with the dye, and ions of the substance to be detected combined with the dye can also penetrate through the polyion gel, so that the concentration measuring part 3 can form dynamic balance with the ions of the substance to be detected, and the continuous measurement of the concentration of the substance to be detected is realized. In addition, the concentration measuring unit 3 contributes to the realization of industrialization and cost reduction.
In a specific embodiment, when the medical detection apparatus is used for measuring the pH of the digestive tract, the concentration measuring part 3 comprises at least a pH measuring part 33, wherein the body part 31 of the pH measuring part 33 may comprise polyion gel and pH sensitive dye, wherein the pH sensitive dye has different colors when the concentration of hydrogen ions in the solution is different.
In the field of medical instruments, when the pH value inside a human body is detected, the pH value is mainly detected in the prior art through the following two modes, namely a pH electrode, the pH value of an environment to be detected can be directly detected by making a material sensitive to hydrogen ions into the electrode and utilizing an electrochemical principle, and the precision is high, such as an antimony electrode. The other scheme is to judge the pH value of the environment to be detected through color change, and the precision is low, such as traditional pH test paper, pH indicator and the like.
When pH is measured by an electrochemical method, the sensor is complex, a reference electrode and a test electrode need to be packaged together, and an ion channel needs to be ensured between the reference electrode and the test environment. For normal use scenarios, glass-electricityElectrode, antimony electrode and hydrogen ion sensitive field effect transistor (H)+SFET) can meet the application requirements. However, for the measurement of the pH value of the digestive tract of a human body, the integration of the pH electrode on the capsule endoscope is extremely difficult and is not easy to realize. In addition, potential biological toxicity exists if antimony electrodes are used as pH electrodes.
Methods for measuring pH by color change have long been available, but such methods are not capable of continuous measurement of different pH environments, nor are they capable of continuous pH measurement integrated into a capsule endoscopic device.
For the above reasons, in the field of medical equipment, there is no technology capable of integrating an endoscope device with a pH measurement sensor, or in the current technology, the equipment formed by integrating the endoscope device with the pH measurement sensor has low reliability and high cost.
In this embodiment, the medical detection device in the present application can acquire pH information of the digestive tract, that is, the medical detection device integrates the pH measurement unit 33, and meanwhile, by changing the structure of the pH measurement unit 33, the integration process can be simplified, and the integration cost can be reduced. The pH measuring component 33 including the polyion gel and the pH sensitive dye can be conveniently integrated (e.g., adhered) with the medical detection device (e.g., capsule endoscope) without using an electrochemical electrode, and is compatible with hardware of the medical detection device after integration without performing secondary packaging, and only related software needs to be modified to perform pH measurement while performing endoscopy, so as to improve the detection accuracy. Meanwhile, by additionally arranging the polyion gel, hydrogen ions in the solution can penetrate through the polyion gel and be combined with the pH sensitive dye, and hydrogen ions combined with the pH sensitive dye can also penetrate through the polyion gel, so that the pH measuring part 33 can form dynamic balance with the hydrogen ions, and the continuous measurement of the pH value is realized. Besides the pH value in the stomach, the pH measuring part 33 can also measure the pH value of organs such as oral cavity, intestinal tract and the like, and can display different colors according to the difference of the pH value of each organ. In addition, the pH measuring unit 3 contributes to industrialization and cost reduction.
Specifically, by changing the amount or kind of the pH sensitive dye in the pH measuring part 33, the span and accuracy of the pH measuring part 33 can be changed. For example, one kind of pH measurement component 33 can satisfy the measurement of pH values of 1, 5, 7, and 8, and the other kind of pH measurement component 33 can satisfy the measurement of pH values of 2, 3, 4, and 6, so when the medical measurement component includes the above two kinds of pH measurement components 33, the pH measurement component can satisfy the measurement of pH values within a range of 1 to 8, and can satisfy the resolution of pH values of 0.5 to 1. The two pH measuring parts 33 are different in the type of the sensitive dye, and the polyion gels of the two pH measuring parts can be the same.
In another embodiment, when the medical detection apparatus is used for measuring the presence and concentration of occult blood in the digestive tract, the concentration measuring part 3 at least comprises an occult blood measuring part 34, wherein the body part 31 of the occult blood measuring part 34 may comprise polyion gel and methylene blue dye, wherein the methylene blue dye has different colors when the concentration of hemoglobin in the solution is different.
In the field of medical equipment, there are two main schemes for detecting the occult blood in the digestive tract. The first scheme is a blood occult bead method, which has the basic principle that a capsule with fine lines is swallowed, the capsule absorbs gastric juice at the tail part and is pulled out through the fine lines, then a color developing agent is dripped on the capsule stained with the gastric juice, and color change is observed to judge whether occult blood is generated. The second scheme is to detect the occult blood condition of the digestive tract by detecting the bleeding condition in the excrement through an occult blood test paper.
The first scheme is only suitable for detecting occult blood in the upper digestive tract and belongs to invasive detection, and discomfort reactions such as vomiting and the like can be caused in the detection process. The second scheme is only suitable for detecting occult blood in the lower digestive tract, especially for detecting the colon and rectum, and is easy to cause the false positive phenomenon of detection due to the influence of hemorrhoids and the like.
In this embodiment, when the occult blood measuring unit 34 including polyion gel and methylene blue dye is used, the polyion gel and the methylene blue dye ion have strong ionic interaction, so that the methylene blue dye ion is kept in the polyion gel without leaking, and the methylene blue dye is a biological stain and has an oxidation effect on hemoglobin, in the reaction process, the methylene blue dye is reduced by hemoglobin and then is converted from blue to colorless, and according to the difference of hemoglobin concentration, the depth of blue is different, and the occult blood condition can be quantitatively detected through color change.
In this example, methylene blue dye is a non-toxic dye, and its oxidized form is blue and its reduced form is colorless. Under the environment of high-concentration hemoglobin, the methylene blue dye has stronger reducing capability in cells due to the metabolism of the cells, under the action of glucose-6-phosphate dehydrogenase, the oxidation type of blue can be changed into colorless or light yellow reduction type, and under the environment of low-concentration hemoglobin, the cells in the environment have no reducing capability or extremely weak reducing capability, and at the moment, the methylene blue dye is blue or light blue. Thus, when the methylene blue dye appears blue or bluish, it indicates a low concentration of hemoglobin in the environment (e.g., the digestive tract), and when the methylene blue dye appears colorless or yellowish, it indicates a high concentration of hemoglobin in the environment (e.g., the digestive tract).
The occult blood measuring unit 34 in the present embodiment can continuously measure the occult blood concentration in different organs, for example, the stomach and the intestinal tract.
Therefore, the medical detection apparatus in the embodiment of the present application integrates the occult blood measurement unit 34, and meanwhile, by changing the structure of the occult blood measurement unit 34, the integration process can be simplified, and the cost can be reduced, and more importantly, the medical detection apparatus can realize noninvasive detection, and has high measurement accuracy.
In yet another embodiment, when the medical detection apparatus is used for measuring pepsin concentration in the digestive tract, the concentration measuring part 3 comprises at least a pepsin measuring part 35, wherein the body part 31 of the pepsin measuring part 35 may comprise a polyion gel and a bromophenol blue dye, wherein the bromophenol blue dye has different colors when the concentration of pepsin in a solution (e.g. digestive tract) is different.
Pepsin in human gastric juice becomes a biological marker of gastritis and gastric cancer diseases, and when intestinal metaplasia, atypical hyperplasia and gastric cancer occur, pepsin secretion is reduced; when the helicobacter pylori is infected or diseases such as gastric ulcer and duodenal ulcer exist, the pepsin value is increased. At present, a large number of statistical analyses indicate that the content change of the serum pepsinogen is related to stomach diseases, and the detection of the serum pepsinogen is considered to have an important role in early diagnosis of the gastric cancer.
At present, the prior art mainly detects the content of pepsin through three ways, the first way is serum collection and in-vitro detection, and the method analyzes by collecting serum of a detected person, but the method collects a sample in vivo and detects in vitro to analyze the specific content of pepsin, so that the detected pepsin is single detection, and has limitation on real-time monitoring of the content of pepsin in gastric juice; in addition, the pepsin only plays a role in an acid environment, and the pepsin loses activity when the pH value is more than 6, so that the pepsin is easily influenced by the environment under an in vitro environment to cause inaccurate test results. The second one relies on gastroscopy to confirm diagnosis, but gastroscopy has certain pain, high cost, limits to the level of doctors and has low patient acceptance. The third is a detection method of a pepsin chemiluminescence immunoassay kit, which adopts the pepsin chemiluminescence immunoassay kit, and the kit comprises a pepsin antigen calibrator, a sample collecting solution, a sample diluent, a pepsin antibody coated microporous plate, a pepsin antibody marker, chemiluminescence substrate solution and concentrated washing solution. The kit can detect the content of pepsin in gastric juice, esophageal contents and laryngeal secretions of pharynx, judge whether gastroesophageal reflux exists according to whether the pepsin can be detected, and judge the treatment effect and the disease change of stomach lesions according to the content of the pepsin. Although the method can detect the pepsin, the process is complex, the requirements on operators and detection equipment are high, and the cost is not low.
In the embodiment of the present application, when the pepsin measuring unit 35 including the polyion gel and the bromophenol blue dye is used, the polyion liquid gel and the bromophenol blue dye ions have strong ionic interaction, so that the bromophenol blue dye ions are kept in the gel and do not leak. The bromophenol blue dye is a biological staining agent, under the condition of different pH values, the bromophenol blue dye is combined with pepsin by means of non-covalent bonds, a hydrophobic core of the pepsin is combined with a nonpolar group of the bromophenol blue dye, the volume of the combined aggregate is larger than that of the bromophenol blue dye, so that the molar absorption coefficient after combination is changed, light scattering signals are changed, different colors are displayed, and the signal intensity of the bromophenol blue dye is in a proportional relation with the number of particles in a unit volume, namely the concentration of the pepsin, so that the detection of the concentration of the pepsin can be realized. In the detection process, the bromophenol blue dye in the pepsin measuring part 35 shows different colors for the concentrations of the pepsin with different concentrations, and the concentrations can be quantitatively detected through color change.
In addition, since pepsin is only present in an acidic environment, and is inactivated and denatured in a neutral or alkaline environment, pepsin is only present in the stomach, and based on this, the pepsin measuring part 35 can be used only for measuring the pepsin concentration in the stomach, and cannot be used in other organs (because pepsin is inactivated in other organs). During detection, pepsin in the stomach is combined with bromophenol blue dye, so that the molar absorption coefficient is changed, the light scattering signal is changed, the color is displayed, and the color and the concentration of the pepsin are in a certain proportion relation, so that the detection of corresponding protein is realized. The pepsin measuring component 35 has different color changes in a range from low concentration to high concentration in a detection environment of an acidic environment, and has a certain continuous detection function; but it does not have continuous detection characteristics when the environment of the solution changes (e.g., from the stomach to the duodenum).
Therefore, the medical detection device in the embodiment of the present application integrates the pepsin measuring component 35, and meanwhile, by changing the structure of the pepsin measuring component 35, the integration process can be simplified, and the cost can be reduced, and more importantly, the medical detection device can realize noninvasive detection, and the measurement accuracy is high.
In yet another embodiment, when the medical detection apparatus is used for measuring trypsin concentration in the digestive tract, the concentration measuring component 3 comprises at least a trypsin measuring component 36, wherein the body portion 31 of the trypsin measuring component 36 may comprise a polyion gel and a bromocresol purple dye, wherein the bromocresol purple dye has different colors when the concentration of trypsin concentration in a solution (e.g., the digestive tract) is different.
In the embodiment of the present application, when the trypsin measuring part 36 including the polyion gel and the bromocresol purple dye is used, the bromocresol purple dye ions can be kept in the gel without leaking due to strong ionic interaction between the polyion liquid gel and the bromocresol purple dye ions. Under different pH values, the bromocresol purple dye is combined with trypsin through a non-covalent bond, a hydrophobic core of the trypsin is combined with a nonpolar group of the bromocresol purple dye, the volume of a combined aggregate is larger than that of the bromocresol purple dye, so that the combined molar absorption coefficient is changed, a light scattering signal is changed, different colors are displayed, and the signal intensity of the bromocresol purple dye is in a proportional relation with the number of particles in unit volume, namely the concentration of the trypsin, so that the concentration of the trypsin can be detected. In the detection process, the bromocresol purple dye in the trypsin measuring part 36 shows different colors for the trypsin concentrations with different concentrations, and the concentrations can be quantitatively detected through color change.
In addition, since trypsin is only present in a weak alkaline environment, an acidic environment is inactivated and denatured, trypsin is present in pancreas, and trypsin in pancreas can flow to duodenum along with pancreatic juice, based on which the trypsin measuring part 36 can be used only for measuring trypsin concentration in pancreas and duodenum, and cannot be used in other organs (because trypsin is inactivated in other organs). During detection, trypsin is combined with bromocresol purple dye, so that the molar absorption coefficient is changed, the light scattering signal is changed, the color is displayed, and the color and the concentration of the trypsin are in a certain proportion relation, so that the detection of corresponding protein is realized. The trypsin measuring component 36 has different color development changes in a range from low concentration to high concentration in a detection environment of a weak alkali environment, and has a certain continuous detection function; but it does not have continuous detection characteristics when the solution environment changes (e.g., from duodenum to jejunum).
Therefore, the medical detection device in the embodiment of the present application integrates the trypsin measuring component 36, and meanwhile, by changing the structure of the trypsin measuring component 36, the integration process can be simplified, and the cost can be reduced, and more importantly, the medical detection device can realize noninvasive detection, and the measurement accuracy is high.
In a specific embodiment, the medical detection device can comprise a plurality of concentration measurement components 3, the measuring ranges of the concentration measurement components 3 are not identical, and/or the resolutions of the concentration measurement components 3 are not identical, and the combination of the concentration measurement components 3 can meet the measurement of the concentrations of various parameters to be measured, thereby improving the measurement accuracy and the measurement range. Alternatively, the medical examination apparatus may have a plurality of concentration measuring sections 3 and pressure measuring sections 2. Meanwhile, when the concentration measuring components 3 are included, the phenomenon that the parameters to be measured cannot be measured or the measuring result is inaccurate due to the fact that a single concentration measuring component 3 fails can be avoided. For example, the medical detection device may include a plurality of pH measurement components 33, and the ranges of the pH measurement components 33 are not completely the same, and/or the resolutions of the pH measurement components 33 are not completely the same, so that by combining a plurality of pH measurement components 33, the measurement of multiple pH values can be satisfied, the measurement accuracy and the measurement range can be improved, and the failure of a single pH measurement component 33 to measure pH value information or inaccurate measurement results can be avoided.
The plurality of concentration measuring means 3 may be the same type of concentration measuring means 3, may be different types of concentration measuring means 3, or may be a combination of a plurality of types of concentration measuring means 3. For example, as shown in the embodiment of fig. 10, the medical test device includes the pressure measuring part 2, the pH measuring part 33, the occult blood measuring part 34, the pepsin measuring part 35, and the trypsin measuring part 36 at the same time, so that the medical test device can be used to measure the pH value, the occult blood concentration, the pepsin concentration, and the trypsin concentration of the digestive tract. In addition, the pH measuring part 33, the occult blood measuring part 34, the pepsin measuring part 35, and the trypsin measuring part 36 may each include one or more so as to improve the accuracy of the measurement. The concentration measuring members 3 may be circular in shape, and the pressure measuring member 2 may be rectangular in shape.
In the embodiment shown in fig. 11, the medical test device comprises a pressure measuring part 2, a pepsin measuring part 35 and a trypsin measuring part 36, thereby enabling the medical test device to be used for measuring pressure in the digestive tract as well as pepsin and trypsin concentrations. In addition, the pressure measuring part 2, the pepsin measuring part 35, and the trypsin measuring part 36 described above may each include one or more so as to improve the accuracy of the measurement. The shape of each of the measuring parts may be rectangular.
In the embodiment shown in fig. 12, the medical test device comprises a pressure measurement part 2, a pH measurement part 33 and a occult blood measurement part 34, thereby enabling the medical test device to measure pressure, pH and occult blood concentration. In addition, the pressure measuring part 2, the pH measuring part 33, and the occult blood measuring part 34 may each include one or more so as to improve the accuracy of measurement. The shape of each of the concentration measuring parts may be circular, and the shape of the pressure measuring part 2 may be rectangular.
In the above embodiments, as shown in fig. 12, in the medical examination apparatus, at least a portion of the housing 1 is the transparent portion 11, and the transparent portion 11 is made of a transparent material having biocompatibility, that is, the environment outside the housing 1 can be observed from the inside of the housing 1 through the transparent portion 11.
Meanwhile, the medical examination device further includes an image component 4, as shown in fig. 1 to 3, the image component 4 is located in an inner cavity of the housing 1, and specifically includes a lens 41, an image sensor 42 and an illumination lamp 43, the lens 41 can receive light of an external environment (for example, a digestive tract of a human body) of the housing 1 through the transparent portion 11 of the housing 1, the image sensor 42 is configured to convert a light signal received by the lens 41 into an electrical signal, the illumination lamp 43 is configured to illuminate, and specifically may be an LED lamp, and the illumination lamp 43 includes an LED structural component 431, so that the image component 4 can shoot and observe a picture of the external environment of the housing 1 through an optical imaging principle. Based on this, the medical detection apparatus in the embodiment of the present application may be an endoscope.
Further, as shown in fig. 2 and fig. 3, the medical detection device further includes a data transmission assembly 5, the data transmission assembly 5 is located in the inner cavity of the housing 1, and specifically includes a data acquisition processing module 51, an antenna 52 and a battery 53, wherein the battery 53 supplies power to each component in the image component 4 and the data transmission assembly 5, the data acquisition processing module 51 is electrically connected or in signal connection with the image component 4, so as to be able to identify and process information in the image component 4, and at the same time, the antenna 52 is used for transmitting the obtained information to an external receiving device.
Specifically, the medical detection device can be a capsule endoscope, during processing, a circuit board of the capsule endoscope is firstly assembled and connected with the image component 4 and the data transmission component 5, when the components are connected, the components are mainly bonded through UV (ultraviolet) glue to form a capsule core with a photographing function, then the capsule core is filled into the shell 1, the capsule core is firstly filled into the lower shell 13, then the upper shell 12 is filled, and the LED structural component 431 is clamped between the upper shell 12 and the lower shell 13, so that the LED structural component 431 is fixed in the position inside the capsule, the capsule core is further fixed inside the shell 1, and the assembly of the capsule endoscope is completed.
Therefore, when the medical detection device is arranged in each part of the human body, the pressure measurement part 2 can display different scales according to different pressures, so that the pressure can be quantitatively detected; its concentration measurement part 3 can be according to the different colours of the volume of awaiting measuring parameter display of different concentration, can carry out quantitative determination to the concentration of the volume of awaiting measuring parameter through the colour change, and the scale of pressure measurement part 2 and the colour change of concentration measurement part 3 can acquire the picture through image part 4's camera lens 41 and judge, and scale information and colour information send to outside receiving equipment and can show in real time through data transmission subassembly 5 to help detecting. Meanwhile, the medical detection device can also shoot and observe pictures of the external environment of the medical detection device through the lens 41 of the imaging part 4, and the picture information can be sent to an external receiving device through the data transmission component 5 and can be displayed in real time, so that the health condition of the part can be judged.
The medical detection equipment in the embodiment of the application can observe the health condition of the alimentary canal mucous membrane by arranging the image component 4 and the data transmission component 5, can measure the pressure in the alimentary canal and the concentration of a parameter to be measured by arranging the pressure measurement component 2 and the concentration measurement component 3, namely, the medical detection equipment integrates the endoscope device, the pressure measurement component 2 and the concentration measurement component 3, and meanwhile, the integration process of the three components can be simplified and the integration cost can be reduced by changing the structure and the type of the concentration measurement component 3.
Specifically, as shown in fig. 3, the lens 41 is installed in the inner cavity of the housing 1, the lens 41 has an effective imaging angle α 1, and the transparent portion 11 of the housing 1 can cover the space where the effective imaging angle α 1 is located, so that the view of the lens 41 is not blocked. Meanwhile, as shown in fig. 3, the image sensor 42 has a display image angle α 2, and the transparent portion 11 of the housing 1 can also cover the space where the display image angle α 2 is located, so that the imaging area of the image sensor 42 is not blocked.
Meanwhile, when the lens 41 and the image sensor 42 are installed, α 1 > α 2 is satisfied, that is, although the lens 41 can capture a picture in the range corresponding to α 1, and the range corresponding to α 1 has the effective imaging angle boundary D1, the image sensor 42 can display the picture in the range corresponding to α 2, and the range corresponding to α 2 has the display image angle boundary D2. For example, the above-described effective imaging angle α 1 may be 140 °, and the display image angle α 2 may be 135 °.
Based on this, in the first embodiment, as shown in fig. 14, the pressure measuring means 2 and/or the concentration measuring means 3 are installed in the transparent part 11, and the space between the effective imaging angle α 1 and the display image angle α 2, that is, the pressure measuring means 2 and/or the concentration measuring means 3 are located between the effective imaging angle boundary D1 and the display image angle boundary D2, and a plurality of pressure measuring means 2 and concentration measuring means 3 may be included between the effective imaging angle boundary D1 and the display image angle boundary D2, and the plurality of pressure measuring means 2 and the plurality of concentration measuring means 3 may be the same type or different types, as in the embodiment shown in fig. 14, the pressure measuring means 2, the pH measuring means 33 and the pepsin measuring means 35 are provided between the effective imaging angle boundary D1 and the display image angle boundary D2, and the measuring parts can be arc-shaped structures and the like.
At this time, the pressure measuring part 2 and the density measuring part 3 cannot be observed in the observation area of the image sensor 42, but the density measuring part 3 is located within the imaging range of the lens 41, and therefore, the lens 41 and the data transmission component 5 can read the color information of the density measuring part 3 and can transmit the scale information and the color information to an external receiving device via the antenna 52, thereby displaying the scale information and the color information by the external receiving device, and obtaining the pressure value and the density value of the parameter to be measured from the color information. Since the pressure measuring part 2 and the concentration measuring part 3 do not occupy the imaging area of the image sensor 42, a complete image of the mucosa of the digestive tract can be observed, and the image can be transmitted to and displayed on an external receiving device via the antenna 52 so as to observe the health condition of the digestive tract.
In another embodiment, as shown in fig. 15, the pressure measuring part 2 and/or the density measuring part 3 is mounted in the transparent part 11 and is located in the space occupied by the display image angle α 2, that is, the pressure measuring part 2 and/or the density measuring part 3 is located inside the display image angle boundary D2 and close to the display image angle boundary D2, so that the pressure measuring part 2 and/or the density measuring part 3 can be prevented from occupying the middle position of the display image range, and the image can be prevented from being blocked by the pressure measuring part 2 and/or the density measuring part 3. At this time, the pressure measuring part 2 and/or the density measuring part 3 are located within the imaging area of the image sensor 42, the image sensor 42 transmits scale information of the pressure measuring part 2 and/or color information of the density measuring part 3 to an external receiving apparatus so that a user can observe the scale of the pressure measuring part 2 and the density measuring part 3 displayed by color, and the scale information and the color information can be transmitted to the external receiving apparatus via the antenna 52 so that the density of the parameter to be measured is displayed on the external receiving apparatus. Therefore, the medical detection device in the embodiment can collect the concentration of the parameter to be measured of the alimentary canal while observing the alimentary canal mucosa.
One or more concentration measuring components 3 and one or more pressure measuring components 2 can be arranged inside the display image angle boundary D2 of the medical detection device, and the plurality of pressure measuring components 2 and the plurality of concentration measuring components 3 can be of the same type or different types, as shown in the embodiment shown in fig. 15, the pressure measuring component 2, the occult blood measuring component 34 and the trypsin measuring component 36 are arranged inside the display image angle boundary D2, and all the three components can be of arc-shaped structures and are close to the display image angle boundary D2.
In yet another embodiment, the pressure measuring part 2 and/or the concentration measuring part 3 are mounted on the transparent part 11 and located in the space occupied by the display image angle α 2, i.e. the pressure measuring part 2 and/or the concentration measuring part 3 is located inside the display image angle boundary D2, and the pressure measuring part 2 and/or the concentration measuring part 3 may be located in the middle of the space occupied by the display image angle α 2.
At this time, the pressure measuring part 2 and/or the density measuring part 3 are located within the imaging area of the image sensor 42, the image sensor 42 transmits the scale of the pressure measuring part 2 and the color information of the density measuring part 3 to the external receiving device, so that the user can observe through the pressure measuring part 2 and the density measuring part 3, and the scale information and the color information can be transmitted to the external receiving device via the antenna 52, so that the external receiving device displays the pressure and the density of the parameter to be measured. Therefore, the medical detection device in the embodiment can collect the pressure of the digestive tract and the concentration of the parameter to be measured while observing the mucous membrane of the digestive tract. Meanwhile, when the pressure measurement component 2 and/or the concentration measurement component 3 are positioned in the middle of the space occupied by the angle alpha 2 of the display image, the user can conveniently observe the pressure measurement component 2 and/or the concentration measurement component 3, and the shielding is reduced, so that the pressure of the alimentary tract and the concentration value of the parameter to be measured are more accurately acquired.
The medical examination apparatus may be provided with one or more concentration measuring parts 3, and the plurality of concentration measuring parts 3 may be of the same type or different types, as in the embodiment shown in fig. 16, a plurality of pressure measuring parts 2, pepsin measuring parts 35, and trypsin measuring parts 36 are provided between the display image angle boundary D2 and the effective imaging angle boundary D1, and each of the pepsin measuring parts 35 and trypsin measuring parts 36 is located at a corner of the field of view, a pH measuring part 33 is provided within the display image angle boundary D2, and the pH measuring part 33 is located at the middle of the space occupied by the display image angle α 2. Each concentration measuring component can be of a circular structure, and the pressure measuring component 2 is of an arc structure.
Meanwhile, as shown in fig. 16, the medical detection apparatus may further include an infrared switch 6, and the infrared switch 6 may function to turn on the pressure measurement part 2 and/or the concentration measurement part 3, so that the pressure measurement part 2 and/or the concentration measurement part 3 of the medical detection apparatus may start to operate.
In the embodiments shown in fig. 14-16, the image angle boundary D2 and the effective imaging angle boundary D1 of the camera 41 of the image component 4 can be circular and concentric. In the embodiment shown in fig. 17, the effective imaging angle boundary D1 of the camera 41 of the camera section 4 may be square, and the image angle boundary D2 may be circular, and at this time, when the pressure measurement section 2 and/or the density measurement section 3 are located between the image angle boundary D2 and the effective imaging angle boundary D1, they may be located at four corners of the effective imaging angle boundary D1.
In a specific embodiment, the arrangement of the pressure measuring parts 2 and the concentration measuring parts 3 on the outer wall of the housing 1 is a divisional arrangement or an alternate arrangement. The partition arrangement mode is that the outer wall of the shell 1 is divided into a plurality of areas, and the pressure measuring component 2 and the concentration measuring component 3 are arranged in different areas. For example, the transparent part 11 is set to 90 degrees clockwise based on the infrared switch 60The pressure measuring part 2 and the concentration measuring part 3 are arranged in different subsections for dividing the interval into four subsections on average; for example, FIG. 15 will be transparentThe part 11 is divided into [45 ] based on the infrared switch 6 on the average in the clockwise direction0，-450]、[450，1350]、[1350， 2250]And [225 ]0，3150]In the four subsections, one subsection is not provided with a measuring part, and the other three subsections are provided with a pressure measuring part 2, a trypsin measuring part 36 and a occult blood measuring part 34, respectively. The partition arrangement mode is that the outer wall of the shell 1 is divided into a plurality of areas, each area is used for simultaneously arranging the pressure measuring component 2 and the concentration measuring component 3, and the number of the pressure measuring component 2 and the concentration measuring component 3 can be one or more. For example, the transparent part 11 is set to 135 degrees based on the infrared switch 6 and calculated clockwise0And-450The diagonal line is divided into two sub-parts for reference average, and each sub-part is provided with a pressure measuring part 2 and a concentration measuring part 3; for example, in FIG. 14, the transparent part 11 is divided into [ -45 ] in the clockwise direction with respect to the infrared switch 60，1350]And [135 ]0，3150]After two sub-parts of (c) [ -45 [ -c0，1350]A pepsin measuring part 35 and a pressure measuring part 2, [135 ] are placed between them0，3150]A pH measuring part 33 and a pressure measuring part 2 are placed between them. The alternating arrangement can maximize the detection result and optimize the detection when the solution (such as liquid in gastrointestinal tract) is less and only part of the shell 1 is immersed in the solution.
On the other hand, in the medical detection apparatus, as shown in the embodiments of fig. 10 to 12, the image unit 4 includes a lens 41, and the lens 41 is used for taking a picture of the digestive tract and acquiring scale information and/or color information of the pressure measurement unit 2 and/or the concentration measurement unit 3. In the present embodiment, the lens 41 may acquire an imaging image of the pressure measurement component 2 and/or the concentration measurement component 3, the imaging image of the pressure measurement component 2 and/or the concentration measurement component 3 is transmitted together with a picture of the digestive tract to an external receiving device via the data transmission assembly 5, and the external receiving device may recognize and display the pressure value and the concentration of the corresponding parameter to be detected according to the imaging image of the pressure measurement component 2 and/or the concentration measurement component 3.
Of course, as shown in fig. 13, the medical examination apparatus may further include two image components 4, specifically, the housing 1 thereof includes a first end portion and a second end portion (an upper shell 12 and a lower shell 13) which are oppositely disposed along the axial direction, and the first end portion and the second end portion may be provided with transparent portions 11, and at the same time, the two image components 4 are respectively disposed corresponding to the two transparent portions 11, wherein the medical examination apparatus may be a dual-lens capsule endoscope.
Specifically, the pressure measuring part 2 and/or the concentration measuring part 3 may be mounted on the outer wall of the first end portion, or may be mounted on the outer wall of the second end portion, in which case one image part 4 of the medical detection apparatus is used for measuring the concentration of the parameter to be measured, and the other image part is used for observing and taking pictures.
Or, in the medical detection device, the first measurement component is installed on the outer wall of the first end portion of the housing 1, the second measurement component is installed on the outer wall of the second end portion, one or more first measurement components may be installed on the first end portion, one or more second measurement components may be installed on the second end portion, and the types of the first measurement component and the second measurement component may be the same or different (that is, the concentration measurement component or the pressure measurement component), the measurement ranges may be the same or different, and when the equivalent ranges are different, the medical detection device can simultaneously satisfy the detection of different concentration ranges and the detection of pressure.
In the embodiment shown in fig. 13, the first end and the second end of the housing 1 are provided with the cameras 41, and the cameras 41 are located at the transparent parts 11 of the first end and the second end, and at the same time, the first end can be provided with the pressure measuring part 2, the pH measuring part 33 and the pepsin measuring part 35, and the second end can be provided with the pressure measuring part 2, the occult blood measuring part 34 and the trypsin measuring part 36, and at this time, the first end of the medical test device can be used for taking pictures of the digestive tract and measuring the pressure, the pH value and the concentration of pepsin in the digestive tract, and the second end of the medical test device can be used for taking pictures of the digestive tract and measuring the pressure, the occult blood concentration and the concentration of trypsin in the digestive tract.
It should be noted that the medical detection apparatus described above may be a capsule endoscope, and of course, other medical detection apparatuses may also be used, such as other image measurement apparatuses like an electronic endoscope.
In a specific embodiment, when the medical examination apparatus is a capsule endoscope device, the medical examination apparatus comprises at least one pressure measurement component 2 and at least one concentration measurement component 3, wherein the capsule endoscope is attached to the surface of the transparent part 11 of the capsule shell 1. Wherein, concentration measurement part 3 can be the loop configuration, inside and outside footpath size can be 5mm and 6mm respectively, thickness can be 40um, of course, its size and thickness can also be other numerical values, and this concentration measurement part 3's noumenon 31 pastes in transparent portion 11 surface through medical UV glue (glue material 32), concentration measurement part 3 can be in effective formation of image angle alpha 1 and display image angle alpha 2 between, do not influence the image display of normal user interface, the measuring result of concentration measurement part 3 is observed to accessible outside receiving arrangement. Meanwhile, the pressure measuring part 2 may have a rectangular structure, the thickness of the pressure measuring part 2 is 150um, the length is 5mm, and the width is 1.5mm, wherein the pressure sensitive film 24 is a polyester film 50um thick, the length of the indication cavity 221 is 50um, and the adhesive 25 employs an acrylate adhesive. The driving portion 21 is a circle having a diameter of 3mm, and is filled with a methylene blue solution having a concentration of 20mg/L as an indicator. Through in vitro calibration experiments, the pressure measurement component 2 can meet the pressure measurement of the digestive tract at 0-30kpa, and the sensitivity can reach 6 kpa.
The above description is only exemplary of the present application and should not be taken as limiting the present application, as any modification, equivalent replacement, or improvement made within the spirit and principle of the present application should be included in the scope of protection of the present application.
Claims (25)
1. A medical testing device comprising:
a housing;
the pressure measuring component is arranged on the outer wall of the shell and used for measuring the pressure of the environment outside the shell;
and the concentration measuring component is arranged on the outer wall of the shell and used for measuring the concentration of the parameter to be measured in the external environment of the shell.
2. The medical testing device of claim 1, wherein the pressure measurement member includes a drive portion, an indicator portion, and an indicator;
the indicating part is provided with an indicating cavity, scales are arranged on the indicating part, and the indicating agent can correspond to different scales when flowing in the indicating cavity;
the driving part can drive the indicator to flow in the indicating cavity when being pressed.
3. The medical testing device of claim 2, wherein the drive portion has a drive lumen in communication with the indicator lumen, and the indicator is disposed within the drive lumen;
when the driving part is pressed, the driving cavity can deform and can press the indicator in the driving cavity into the indicating cavity.
4. The medical testing device of claim 3, wherein the drive portion includes a pressure sensitive membrane enclosing the drive cavity;
when the pressure is applied, the pressure-sensitive film can deform towards the inside of the driving cavity, and when the pressure disappears, the pressure-sensitive film can restore to the original state.
5. The medical testing device of claim 3, wherein the driving portion and the indicating portion are integrally formed, each of the driving portion and the indicating portion including a pressure sensitive membrane enclosing the driving chamber and the indicating chamber;
the cross-sectional area of the drive chamber is greater than the cross-sectional area of the indicator chamber.
6. The medical examination device of claim 2, wherein the drive section includes a gas chamber and a liquid chamber separated by a drive plate, the volumes of the gas chamber and the liquid chamber being adjusted by movement of the drive plate;
the liquid cavity is provided with the indicator, the indicator in the liquid cavity can enter the indicating cavity, and the indicator in the indicating cavity can also enter the liquid cavity.
7. The medical detection device as claimed in any one of claims 2 to 6, wherein the indicator is one of methylene blue, beet red, vitamin B.
8. The medical detection device according to any one of claims 1 to 6, wherein the concentration measurement member includes a polyion gel and a dye, the dye being filled in the polyion gel;
the dye can change color when the concentration of the parameter to be measured is different.
9. The medical testing device of claim 8, wherein the concentration measurement component comprises one or more of a pH measurement component, a occult blood measurement component, a pepsin measurement component, and a trypsin measurement component.
10. The medical detection device of claim 9, wherein the dye of the pH measurement component is a pH sensitive dye that is capable of changing color in environments with different pH values.
11. The medical detection device of claim 10, wherein hydrogen ions in the environment external to the housing are capable of entering the pH measurement component through the polyionic gel, and hydrogen ions in the pH measurement component are capable of entering the environment external to the housing through the polyionic gel;
the pH sensitive dye can bind to or separate from hydrogen ions to form a dynamic equilibrium.
12. The medical detection device of claim 9, wherein the dye of the occult blood measurement component comprises a methylene blue dye that is capable of changing color in environments with different occult blood concentrations.
13. The medical testing device of claim 12, wherein hemoglobin in the environment external to the housing is capable of binding to and reacting with the polyionic gel and the methylene blue dye in the occult blood measurement component;
under the effect of hemoglobin, through redox reaction, the methylene blue dye can show the colour, and the concentration of hemoglobin is different, the colour that the methylene blue dye shows is different.
14. The medical testing device of claim 9, wherein said dye of said pepsin measuring means comprises a bromophenol blue dye, said bromophenol blue dye being capable of changing color in environments with different pepsin concentrations.
15. The medical testing device of claim 14, wherein pepsin in the environment external to said housing is capable of binding to said polyionic gel and said bromophenol blue dye in said pepsin measurement component;
and the combined light scattering signals of the bromophenol blue dye change to show different colors, and the bromophenol blue dye has different colors when the concentration of pepsin is different.
16. The medical testing device of claim 9, wherein said dye of said trypsin measuring component comprises bromocresol purple dye, said bromocresol purple dye being capable of changing color in environments with different trypsin concentrations.
17. The medical testing device of claim 16, wherein trypsin in the environment external to the housing is capable of binding to the polyionic gel and the bromocresol purple dye in the trypsin measuring component;
the volume of the combined bromocresol purple dye is changed, the light scattering signal of the bromocresol purple dye is changed, different colors are displayed, and the colors of the bromocresol purple dye are different when the concentration of trypsin is different.
18. The medical detection apparatus according to claim 1, wherein the arrangement of the pressure measurement member and the concentration measurement member on the outer wall of the housing is a divisional arrangement or an alternate arrangement.
19. The medical examination device of any one of claims 1 to 6, wherein the medical examination device comprises a plurality of the measurement members;
the ranges of the measurement components are not exactly the same, and/or the resolutions of the measurement components are not exactly the same.
20. The medical testing device of any of claims 1-6, wherein the housing comprises a transparent portion;
the medical detection equipment further comprises an image component, wherein the image component is located in the inner cavity of the shell, and the image component can observe the environment outside the shell through the transparent part.
21. The medical testing device of claim 20, wherein said housing includes first and second oppositely disposed end portions in an axial direction, each of said first and second end portions including said transparent portion;
the medical detection equipment comprises two image parts, wherein the two image parts are respectively arranged corresponding to the two transparent parts;
one of the concentration measuring member and the pressure measuring member is attached to an outer wall of the first end portion, and the other is attached to an outer wall of the second end portion; or,
the concentration measuring part and the pressure measuring part are both arranged on the outer wall of the first end part or the outer wall of the second end part; or,
the outer wall of the first end is provided with a first concentration measuring component and a first pressure measuring component, the outer wall of the second end is provided with a second concentration measuring component and a second pressure measuring component, the ranges of the first concentration measuring component and the second concentration measuring component are different, and the ranges of the first pressure measuring component and the second pressure measuring component are different.
22. The medical testing device of claim 20, further comprising a data transmission assembly;
the image component comprises a lens and an image sensor, and the lens is connected with the image sensor through a mechanical structure and/or glue;
the image sensor is electrically connected or in signal connection with the data transmission assembly, and the lens is connected with the data transmission assembly through a mechanical structure and/or glue.
23. The medical detection device according to claim 22, wherein the lens is mounted in the inner cavity of the housing, the lens has an effective imaging angle α 1, and the transparent portion can cover a space where the effective imaging angle α 1 is located;
the image sensor is provided with a display image angle alpha 2, the transparent part can cover the space where the display image angle alpha 2 is located, and alpha 1 is larger than alpha 2;
the concentration measuring component and/or the pressure measuring component are/is arranged on the outer wall of the shell and positioned in a space between the effective imaging angle alpha 1 and the display image angle alpha 2;
the data transmission assembly is capable of reading data of the concentration measurement component and/or the pressure measurement component.
24. The medical detection device according to claim 22, wherein the lens is mounted in the inner cavity of the housing, the lens has an effective imaging angle α 1, and the transparent portion can cover a space where the effective imaging angle α 1 is located;
the image sensor is provided with a display image angle alpha 2, the transparent part can cover the space where the display image angle alpha 2 is located, and alpha 1 is larger than alpha 2;
the concentration measuring component and/or the pressure measuring component are/is arranged on the outer wall of the shell and positioned in the space occupied by the display image angle alpha 2;
the image sensor is capable of recognizing data of the concentration measuring part and/or the pressure measuring part.
25. The medical examination device of claim 24, wherein the concentration measurement means and/or the pressure measurement means are located in the middle of the space occupied by the display image angle α 2.
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| CN202020283172.5U CN212853470U (en) | 2020-03-10 | 2020-03-10 | Medical detection equipment |
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