CN212663542U

CN212663542U - Mixing arrangement for intermediate of medicine

Info

Publication number: CN212663542U
Application number: CN202021065155.0U
Authority: CN
Inventors: 古大军; 司体明; 郑列伟; 包戚明; 黄伟斌; 胡佳
Original assignee: Hangzhou Fst Pharmaceutical Co ltd
Current assignee: Hangzhou Fst Pharmaceutical Co ltd
Priority date: 2020-06-11
Filing date: 2020-06-11
Publication date: 2021-03-09
Anticipated expiration: 2030-06-11

Abstract

The utility model discloses a mixing arrangement for medical intermediate relates to acetyl tetrahydrofuran production field, including mixing the storehouse, the top of mixing the storehouse is provided with the feed inlet, and one side of feed inlet installs hybrid motor, hybrid motor's output is connected with the action wheel, and the outside of action wheel is connected with from the driving wheel, the outside from the driving wheel is provided with the fixed disk, and the inner wall connection of fixed disk has tooth. The utility model discloses a mixed storehouse, the feed inlet, hybrid motor, the action wheel, from the driving wheel, the fixed disk, the tooth, the (mixing) shaft, stirring vane, it can drive the action wheel and rotate to have realized hybrid motor, the action wheel can drive four groups and rotate from the driving wheel, and because tooth and four groups in the fixed disk mesh from the driving wheel mutually, so four groups not only take place the rotation from the driving wheel but also rotate around the action wheel, will make five groups (mixing) shaft and stirring vane rotate like this, can make the mixed effect of material better in the mixed storehouse.

Description

Mixing arrangement for intermediate of medicine

Technical Field

The utility model relates to an acetyl tetrahydrofuran production field specifically is a mixing arrangement for medical intermediate body.

Background

The prior synthesis process of acetyltetrahydrofuran takes tetrahydrofuran formic acid as a starting material, obtains a target substance through resolution, dissociation, activation and Grignard reaction, obtains tetrahydrofuran formic acid phenethylamine salt through resolution reaction by using R-type phenethylamine, uses equivalent sulfuric acid to dissociate, filters and filters phenethylamine sulfate, can obtain S-tetrahydrofuran formic acid, avoids using hydrochloric acid and other aqueous reagents, has high dissociation yield and 38 percent yield, obtains high-purity R-tetrahydrofuran formic acid through resolution by using S-type phenethylamine, has 35 percent yield and wide application range of R-tetrahydrofuran formic acid, can be used for synthesizing faropenem, the product can be sold as a byproduct, the production cost is reduced, the S-tetrahydrofuran formic acid and carbonyl diimidazole form an active intermediate, then methyl magnesium chloride is dropwise added, the reaction is finished, and the target acetyl tetrahydrofuran can be obtained through simple post-treatment, wherein the yield is 85%.

In the production process of acetyl tetrahydrofuran, S-tetrahydrofuran formic acid, carbonyl diimidazole and methyl magnesium chloride need to be mixed and stirred, but the mixing effect of the existing mixing device is poor, the existing mixing device is added from a feed inlet when solution is replenished, the solution enters the material from the top of the material, a certain time is needed for the solution to permeate the material, and the S-tetrahydrofuran formic acid, the carbonyl diimidazole and the methyl magnesium chloride cannot be well fused.

SUMMERY OF THE UTILITY MODEL

The utility model aims to provide a: in order to solve the problems that the mixing effect of the existing mixing device is poor, the existing mixing device is added from a feed inlet when solution is added, the solution enters the material from the top end of the material and needs a certain time to permeate the material, and the solution and the material cannot be well mixed, the mixing device for the medical intermediate is provided.

In order to achieve the above object, the utility model provides a following technical scheme: the utility model provides a mixing arrangement for medical intermediate, is including mixing the storehouse, the top of mixing the storehouse is provided with the feed inlet, and one side of feed inlet installs hybrid motor, hybrid motor's output is connected with the action wheel, and the outside of action wheel is connected with from the driving wheel, the outside from the driving wheel is provided with the fixed disk, and the inner wall connection of fixed disk has the tooth, the action wheel all is connected with the (mixing) shaft with the bottom from the driving wheel, and the outside of (mixing) shaft is connected with stirring vane, the inside both sides of mixing the storehouse all are provided with the liquid feeding pipe, and the inside of.

Preferably, the number of feed inlets is two sets of, two sets of the top of feed inlet all is provided with sealed lid, and sealed lid and feed inlet rotate to be connected.

Preferably, the number of the driven wheels is four, the four driven wheels are all meshed with the driving wheel, the four driven wheels are all meshed with the teeth, and the driven wheels are rotatably connected with the fixed disc.

Preferably, the top of following the driving wheel is connected with the connecting axle, and the top of connecting axle is provided with the slider, the inside top of mixing the storehouse be provided with slider assorted spout, and follow the driving wheel and pass through slider and spout rotation connection with mixing the storehouse.

Preferably, the number of the stirring shafts is five, and the five stirring shafts are detachably connected with the driving wheel and the driven wheel through couplers respectively.

Preferably, the quantity of through-hole is the multiunit, the multiunit the through-hole equidistance distributes in the inside of liquid feeding pipe, the bottom in mixing the storehouse is connected with the discharge pipe, and the outside of discharge pipe is connected with the control valve.

Compared with the prior art, the beneficial effects of the utility model are that:

1. the utility model discloses a mixed storehouse, the feed inlet, hybrid motor, the action wheel, from the driving wheel, the fixed disk, the tooth, the (mixing) shaft, stirring vane, it can drive the action wheel and rotate to have realized hybrid motor, the action wheel can drive four groups and rotate from the driving wheel, and because tooth and four groups in the fixed disk mesh from the driving wheel mutually, so four groups not only take place the rotation from the driving wheel but also rotate around the action wheel, will make five groups (mixing) shaft and stirring vane rotate like this, can make the mixed effect of material better in the mixed storehouse.

2. The utility model discloses a liquid feeding pipe, the through-hole that set up, the discharge pipe, when having realized adding solution in the inside material of mixed storehouse through the liquid feeding pipe, because the liquid feeding pipe extends to the bottom that mixes the storehouse inside always is the bottom of material, so when filling liquid solution, solution can get into the inside of material from each through-hole, not get into from the top, but get into from the intermediate position department of material, just so can subtract the time that solution got into in the material, shorten the reaction time with the material, make solution and material mixed effect better.

Drawings

Fig. 1 is a cross-sectional view of the present invention;

FIG. 2 is a schematic structural view of the fixing plate of the present invention;

fig. 3 is a schematic view of the sliding chute structure of the present invention.

In the figure: 1. a mixing bin; 2. a feed inlet; 3. a hybrid motor; 4. a driving wheel; 5. a driven wheel; 6. fixing the disc; 7. teeth; 8. a stirring shaft; 9. a stirring blade; 10. a liquid feeding pipe; 11. a through hole; 12. a discharge pipe; 13. a slider; 14. a chute.

Detailed Description

The technical solutions in the embodiments of the present invention will be described clearly and completely with reference to the accompanying drawings in the embodiments of the present invention, and it is obvious that the described embodiments are only some embodiments of the present invention, not all embodiments. Based on the embodiments in the present invention, all other embodiments obtained by a person skilled in the art without creative work belong to the protection scope of the present invention.

In the description of the present invention, it should be noted that the terms "center", "upper", "lower", "left", "right", "vertical", "horizontal", "inner", "outer", and the like indicate orientations or positional relationships based on the orientations or positional relationships shown in the drawings, and are only for convenience of description and simplification of description, but do not indicate or imply that the device or element referred to must have a specific orientation, be constructed and operated in a specific orientation, and thus, should not be construed as limiting the present invention. Furthermore, the terms "first," "second," and "third" are used for descriptive purposes only and are not to be construed as indicating or implying relative importance. In the description of the present invention, it is to be noted that, unless otherwise explicitly specified or limited, the terms "mounted", "connected" and "disposed" are to be construed broadly, and may be, for example, fixedly connected, detachably connected, or integrally connected; can be mechanically or electrically connected; they may be connected directly or indirectly through intervening media, or they may be interconnected between two elements. The specific meaning of the above terms in the present invention can be understood in specific cases to those skilled in the art. The following describes an embodiment of the present invention according to its overall structure.

The hybrid motor (model 100-3700) mentioned in the present invention can be obtained by market or private ordering.

Please refer to fig. 1-3, a mixing device for a medical intermediate, comprising a mixing bin 1, wherein a feed inlet 2 is arranged at the top end of the mixing bin 1, a mixing motor 3 is installed at one side of the feed inlet 2, an output end of the mixing motor 3 is connected with a driving wheel 4, an outer side of the driving wheel 4 is connected with a driven wheel 5, an outer side of the driven wheel 5 is provided with a fixed disk 6, an inner wall of the fixed disk 6 is connected with teeth 7, bottom ends of the driving wheel 4 and the driven wheel 5 are both connected with a stirring shaft 8, an outer side of the stirring shaft 8 is connected with stirring blades 9, two sides of the interior of the mixing bin 1 are both provided with liquid feeding tubes.

The utility model discloses a mixed storehouse 1 that sets up, feed inlet 2, hybrid motor 3, action wheel 4, from driving wheel 5, fixed disk 6, tooth 7, the (mixing) shaft 8, stirring vane 9, it can drive action wheel 4 and rotate to have realized hybrid motor 3, action wheel 4 can drive four groups and rotate from driving wheel 5, and because tooth 7 and four groups in the fixed disk 6 mesh from driving wheel 5 mutually, so four groups not only take place the rotation from driving wheel 5 but also rotate around action wheel 4, will make five groups (mixing) shaft 8 and stirring vane 9 rotate like this, can make the mixed effect of material better in the mixed storehouse 1.

Please refer to fig. 1, the number of the feeding ports 2 is two, and the top ends of the two feeding ports 2 are provided with sealing covers, and the sealing covers are rotatably connected with the feeding ports 2, so that the sealing covers can prevent the inner part from falling ash when the device is not used, and can also prevent gas from overflowing during the use process.

Please refer to fig. 2, the number of the driven wheels 5 is four, four sets of the driven wheels 5 are all engaged with the driving wheel 4, and four sets of the driven wheels 5 are all engaged with the teeth 7, the driven wheels 5 are rotatably connected with the fixed disc 6, and the driving wheel 4 only rotates and does not move.

Please refer to fig. 3, the top end of the driven wheel 5 is connected with a connecting shaft, the top end of the connecting shaft is provided with a sliding block 13, the top end inside the mixing bin 1 is provided with a sliding chute 14 matched with the sliding block 13, the driven wheel 5 and the mixing bin 1 are rotatably connected through the sliding block 13 and the sliding chute 14, the four groups of sliding blocks 13 rotatably slide inside the sliding chute 14, the top end inside the mixing bin 1 is provided with a connecting hole, the output shaft of the mixing motor 3 penetrates through the connecting hole and extends to the inside of the mixing bin 1, and the outer side of the connecting hole.

Please refer to fig. 1, the number of the stirring shafts 8 is five, the five groups of stirring shafts 8 are detachably connected with the driving wheel 4 and the driven wheel 5 through the shaft coupling respectively, and the five groups of stirring blades 9 are distributed at intervals, so that the conditions of mutual collision and the like can not occur during rotation.

Please refer to fig. 1, the number of the through holes 11 is multiple, the multiple through holes 11 are distributed in the liquid feeding pipe 10 at equal intervals, the bottom end of the mixing bin 1 is connected with the discharge pipe 12, the outer side of the discharge pipe 12 is connected with the control valve, the liquid feeding pipe 10 is a hollow cylinder structure, and the bottom end is sealed.

The working principle is as follows: when the device is used, an external power supply is required to be connected, the external power supply provides electric energy for the device, so that the device can normally run, different materials firstly enter the mixing bin 1 through the two groups of feed inlets 2, the mixing motor 3 is started to be mixed, the mixing motor 3 is started to drive the driving wheel 4 to rotate, the driving wheel 4 drives the four groups of driven wheels 5 meshed with the driving wheel 4 to rotate when rotating, the driven wheels 5 are meshed with the teeth 7 on the inner wall of the fixed disk 6, so that the four groups of driven wheels 5 rotate and simultaneously rotate around the driving wheel 4 in the fixed disk 6, the stirring blades 9 can be driven by the four groups of stirring shafts 8 to rotate and revolve in the mixing bin 1, a better mixing effect can be achieved by matching the middle group of rotating stirring shafts 8 and stirring blades 9, and a solution is required to be added after the materials are mixed, inside can add the material through two sets of liquid feeding pipes 10, because inside liquid feeding pipe 10 deepened the material, so the inside solution of liquid feeding pipe 10 can be discharged through each through-hole 11, the inside of the solution direct entering material that the through-hole of co-altitude spills over, needn't slowly permeate from the top, shorten the reaction time of solution and material, after solution fills, can start hybrid motor 3 and drive material and solution and mix once more, thereby make solution and material accelerated reaction, the mixed effect is better.

It is obvious to a person skilled in the art that the invention is not restricted to details of the above-described exemplary embodiments, but that it can be implemented in other specific forms without departing from the spirit or essential characteristics of the invention. The present embodiments are therefore to be considered in all respects as illustrative and not restrictive, the scope of the invention being indicated by the appended claims rather than by the foregoing description, and all changes which come within the meaning and range of equivalency of the claims are therefore intended to be embraced therein. Any reference sign in a claim should not be construed as limiting the claim concerned.

Claims

1. A mixing arrangement for medical intermediates, comprising a mixing cartridge (1), characterized in that: the top of mixing storehouse (1) is provided with feed inlet (2), and one side of feed inlet (2) installs hybrid motor (3), the output of hybrid motor (3) is connected with action wheel (4), and the outside of action wheel (4) is connected with from driving wheel (5), the outside from driving wheel (5) is provided with fixed disk (6), and the inner wall of fixed disk (6) is connected with tooth (7), action wheel (4) and the bottom from driving wheel (5) all are connected with (mixing) shaft (8), and the outside of (mixing) shaft (8) is connected with stirring vane (9), the inside both sides of mixing storehouse (1) all are provided with liquid feeding pipe (10), and the inside of liquid feeding pipe (10) is provided with through-hole (11).

2. A mixing device for pharmaceutical intermediates according to claim 1, wherein: the quantity of feed inlet (2) is two sets of, two sets of the top of feed inlet (2) all is provided with sealed lid, and sealed lid and feed inlet (2) rotate to be connected.

3. A mixing device for pharmaceutical intermediates according to claim 1, wherein: the number of the driven wheels (5) is four, the driven wheels (5) are all meshed with the driving wheel (4), the driven wheels (5) are all meshed with the teeth (7), and the driven wheels (5) are rotatably connected with the fixed disk (6).

4. A mixing device for pharmaceutical intermediates according to claim 1, wherein: the top of following driving wheel (5) is connected with the connecting axle, and the top of connecting axle is provided with slider (13), the inside top of mixing storehouse (1) is provided with and slider (13) assorted spout (14), and follows driving wheel (5) and mix storehouse (1) and pass through slider (13) and spout (14) and rotate and be connected.

5. A mixing device for pharmaceutical intermediates according to claim 1, wherein: the number of the stirring shafts (8) is five, and the five stirring shafts (8) are detachably connected with the driving wheel (4) and the driven wheel (5) through couplers respectively.

6. A mixing device for pharmaceutical intermediates according to claim 1, wherein: the quantity of through-hole (11) is the multiunit, multiunit through-hole (11) equidistance distributes in the inside of liquid feeding pipe (10), the bottom of mixing storehouse (1) is connected with discharge pipe (12), and the outside of discharge pipe (12) is connected with the control valve.