CN212631839U - Chromatographic column - Google Patents

Abstract

The utility model discloses a chromatographic column, including the column cap flange, the screw rod, the column casing, the bed hedgehopping piece, a spring, the spring pipe, the piston head, sieve and column tail flange, column tail flange mounting is at the tail end of column casing, the tail end at the column casing is installed to one of them piston head, the terminal installation sieve of piston head, pour into the homogenate solvent in the column casing, the sieve, another piston head, the spring pipe, a spring, the bed hedgehopping piece is installed in the column casing, the spring housing is outside the spring pipe, the screw rod flange is connected with the screw rod, the screw rod is placed in the column casing and is located bed hedgehopping piece top, the column cap flange is fixed with the column casing, the screw rod flange is located between column casing. The utility model discloses with the column cap flange and the post tail flange and the column casing separation of chromatographic column, through threaded connection, alleviateed the weight of column casing, column cap flange and post tail flange are screwed up to the spanner, and the succinct convenient dress post of operation guarantees to load the quality.

Description

Chromatographic column

Technical Field

The utility model relates to a chromatographic column field, concretely relates to chromatographic column.

Background

Chromatographic separation technology, one of the most important separation and purification technologies in pharmaceutical active ingredient separation technology, has been developed from analytical scale to preparative and production scale, and has developed into an important method for large-scale separation and preparation of pharmaceutical, particularly Chinese medicinal active ingredients. At present, most of chromatographic column tubes designed and developed domestically are integrated with flanges at two ends and column tubes in structural design, large-size column tubes are excessively heavy and are fixedly connected with screw flanges and column tail flanges through a plurality of bolt and nuts, the process is excessively complicated, the operation is very inconvenient, and the filling effect is unstable.

SUMMERY OF THE UTILITY MODEL

In order to solve the defects of the prior chromatographic column, the utility model provides a chromatographic column.

In order to achieve the above object, the utility model provides a following technical scheme:

a chromatographic column comprises a column head flange, a screw rod, a column tube, a heightening block, a spring guide pipe, a piston head, a sieve plate and a column tail flange, wherein the column tail flange is installed at the tail end of the column tube, one piston head is installed at the tail end of the column tube, the sieve plate is installed at the tail end of the piston head, a homogenizing solvent is poured into the column tube, the sieve plate, the other piston head, the spring guide pipe, the spring and the heightening block are installed in the column tube, the spring is sleeved outside the spring guide pipe, the screw rod flange is connected with the screw rod, the screw rod is placed in the column tube and located above the heightening block, the column head flange is fixed with the.

Preferably, the cylinder head device further comprises a piston head backing ring, wherein the piston head backing ring is positioned between the piston head end arranged at the tail part of the cylinder tube and the inner wall of the cylinder tube.

Preferably, a sealing ring is arranged between the piston head and the column tube.

Preferably, a first pipeline is vertically arranged in the middle of the sieve plate positioned at the tail of the chromatographic column, and the first pipeline passes through the piston head; and a second pipeline is vertically arranged in the middle of the sieve plate positioned in the middle of the chromatographic column, and the second pipeline upwards passes through the piston head and the spring guide pipe.

Preferably, the column tail flange is threadedly connected to the column tube.

Preferably, the spring is a disc spring.

Preferably, the outer ends of the column head flange and the column tail flange are hexagonal.

Compared with the prior art, the beneficial effects of the utility model are that:

the utility model separates the column head flange and the column tail flange of the chromatographic column from the column tube, reduces the weight of the column tube by threaded connection, and the column head flange and the column tail flange are screwed by the wrench, so the operation is simple, the column is convenient to assemble, and the filling quality is ensured; after the column is filled and the column head flange is locked, the deformation of the disc spring is utilized to provide a continuous adaptive pressure for the packing, and column head collapse which is possibly generated by the deposition of a column bed in the use of the chromatographic column is eliminated at any time.

Drawings

Fig. 1 is a schematic view of an embodiment of the present invention.

Detailed Description

The technical solutions in the embodiments of the present invention will be described clearly and completely with reference to the accompanying drawings in the embodiments of the present invention, and it is obvious that the described embodiments are only some embodiments of the present invention, not all embodiments. Based on the embodiments in the present invention, all other embodiments obtained by a person skilled in the art without creative work belong to the protection scope of the present invention.

Please refer to fig. 1, the embodiment of the present invention discloses a chromatographic column, including column cap flange 1, screw rod flange 2, screw rod 3, column tube 4, block 5 for raising, spring 7, spring conduit 8, piston head 9, sieve plate 11 and column tail flange 14, column tail flange 14 is installed at the tail end of column tube 4, one of them piston head 9 is installed at the tail end of column tube 4, sieve plate 11 is installed at the end of piston head 9, pour into the homogenate solvent in column tube 4, sieve plate 11, another piston head 9, spring conduit 8, spring 7, block 5 for raising is installed in column tube 4, spring 7 cover is outside spring conduit 8, screw rod flange 2 is connected with screw rod 3, screw rod 3 is placed in column tube 4 and is located block for raising 5 top, column cap flange 1 is fixed with column tube 4, screw rod flange 2 is located between column tube 4 and column cap flange 1.

In an embodiment of the present invention, the present invention further comprises a piston head gasket 15, and the piston head gasket 15 is located between the end of the piston head 9 installed at the tail of the column tube 4 and the inner wall of the column tube 4.

In an embodiment of the present invention, a sealing ring 10 is installed between each of the 2 piston heads 9 and the column tube 4.

In one embodiment of the present invention, a first pipeline 16 is vertically installed in the middle of the sieve plate 11 at the tail of the chromatographic column, and the first pipeline 16 passes through the piston head 9; and a second pipeline 6 is vertically arranged in the middle of the sieve plate positioned in the middle of the chromatographic column, and the second pipeline 6 upwards passes through the piston head 9 and the spring guide pipe 8.

In an embodiment of the present invention, the column tail flange 14 is screwed to the column pipe 4.

In an embodiment of the present invention, the spring is a disc spring.

In an embodiment of the present invention, the outer ends of the column head flange and the column tail flange are hexagonal. The column head flange and the column tail flange are convenient to screw down by a wrench.

Before column installation, a column tail flange 14 is screwed by a wrench to be fixed with a column tube 4, a piston head backing ring 15, a piston head 9, a sealing ring 10 and a sieve plate 11 are installed, the whole chromatographic column is placed on a column installation system, a homogenizing solvent is poured in, the sieve plate 11, the piston head 9, the sealing ring 10, a spring guide pipe 8, a disc spring 7 and a heightening block 5 are sequentially placed in the column tube 4, after filling materials are completed, a screw flange 2 is screwed into a screw 3 to be matched with the screw and is placed in the column tube 4, finally, a column head flange 1 is screwed into the column tube 4 by the wrench, and the screw flange 2 is fixed at the same time. After the column is filled and the column head flange 1 is locked, the deformation of the disc 7 spring is used for providing a continuous adaptive pressure for the packing, and the column head collapse which is possibly generated by the deposition of a column bed in the use of the chromatographic column is eliminated at any time.

The foregoing is merely exemplary and illustrative of the structure of the invention, and various modifications, additions and substitutions as described in the detailed description may be made by those skilled in the art without departing from the structure or scope of the invention as defined in the accompanying claims.

Claims (7)

1. A chromatography column, characterized by: the column head flange is fixed with the column head flange, and the screw rod flange is positioned between the column pipe and the column head flange.

2. A chromatography column according to claim 1, wherein: the plunger piston head cushion ring is arranged between the end of the plunger head arranged at the tail part of the column tube and the inner wall of the column tube.

3. A chromatography column according to claim 1, wherein: and a sealing ring is arranged between the piston head and the column tube.

4. A chromatography column according to claim 1, wherein: a first pipeline is vertically arranged in the middle of the sieve plate positioned at the tail of the chromatographic column and penetrates through the piston head; and a second pipeline is vertically arranged in the middle of the sieve plate positioned in the middle of the chromatographic column, and the second pipeline upwards passes through the piston head and the spring guide pipe.

5. A chromatography column according to claim 1, wherein: the column tail flange is in threaded connection with the column pipe.

6. A chromatography column according to claim 1, wherein: the spring is a disc spring.

7. A chromatography column according to claim 1, wherein: the outer ends of the column head flange and the column tail flange are hexagonal.

Images