CN212594057U

CN212594057U - 4-methoxy methyl acetoacetate crude vacuum distillation plant

Info

Publication number: CN212594057U
Application number: CN202020736277.1U
Authority: CN
Inventors: 陈文阳; 陈文飞; 李康
Original assignee: CHANGZHOU HUAREN CHEMICAL CO LTD
Current assignee: CHANGZHOU HUAREN CHEMICAL CO LTD
Priority date: 2020-05-08
Filing date: 2020-05-08
Publication date: 2021-02-26
Anticipated expiration: 2030-05-08

Abstract

The utility model discloses a 4-methoxy methyl acetoacetate crude vacuum distillation plant, including frame, cupping jar, condenser pipe, receiving tank and retort, the top of frame is equipped with the cupping jar, and installs on the frame outer wall of cupping jar top and bear the frame to bear the central point department of putting on frame top and placed the retort, the central point department of putting on retort top is equipped with annotates the liquid mouth, and the bottom of annotating the liquid mouth extends to the inside of retort, and annotates the top of liquid mouth and install the sealing plug, and the top of sealing plug extends to the outside of annotating the liquid mouth to the central point department of putting on sealing plug top installs the thermometer, and the bottom of thermometer extends to the inside of annotating the liquid mouth, the below of cupping jar is equipped with places the platform, and the central point department of putting the platform bottom is equipped with the logical groove of. The utility model discloses not only improve the distillation effect when distillation plant uses, improved the convenience when distillation plant uses, reduced the phenomenon that produces the leakage when distillation plant uses moreover.

Description

4-methoxy methyl acetoacetate crude vacuum distillation plant

Technical Field

The utility model relates to a medicine distillation technical field specifically is a 4-methoxy methyl acetoacetate crude vacuum distillation plant.

Background

The 4-methoxy methyl acetoacetate is an important intermediate for synthesizing novel anti-HIV/AIDS drug dolutegravir, and as a starting material of dolutegravir, the research on a high-quality and low-cost synthesis method has important significance.

The existing distillation devices on the market are various in types and can basically meet the use requirements of people, but certain defects still exist, and the specific problems are as follows.

(1) The existing distilling device is inconvenient for decompressing the interior of the distilling flask, is difficult to reduce the boiling point of the extract to be extracted, improves the vaporization effect and further improves the distilling efficiency;

(2) the existing distillation device is inconvenient for adjusting the height of the cupping jar, the distance between the cupping jar and the distillation flask is difficult to adjust according to the specific distillation requirement, and the use is inconvenient;

(3) the existing distilling device is inconvenient for sealing the liquid outlet and the liquid inlet, so that the phenomenon of leakage is easy to occur, and people are often troubled.

SUMMERY OF THE UTILITY MODEL

An object of the utility model is to provide a 4-methoxy methyl acetoacetate crude vacuum distillation plant to it is not convenient for carry out the problem of decompression processing, be not convenient for adjust the height of cupping jar and be not convenient for carry out sealing treatment to liquid outlet and inlet position to solve the inside of distillation flask to propose distillation plant among the above-mentioned background art.

In order to achieve the above object, the utility model provides a following technical scheme: a4-methoxy methyl acetoacetate crude product reduced pressure distillation device comprises a frame, a fire pot, a condensation pipe, a receiving pot and a distillation flask, wherein the fire pot is arranged above the frame, a bearing frame is arranged on the outer wall of the frame above the fire pot, the distillation flask is placed at the central position of the top end of the bearing frame, a liquid injection port is arranged at the central position of the top end of the distillation flask, the bottom end of the liquid injection port extends into the distillation flask, a sealing plug is arranged at the top of the liquid injection port, the top end of the sealing plug extends to the outside of the liquid injection port, a thermometer is arranged at the central position of the top end of the sealing plug, the bottom end of the thermometer extends into the inside of the liquid injection port, a placing table is arranged below the fire pot, a lifting through groove is arranged at the central position of the bottom of the placing table, a lead screw is arranged at the central position of the lifting through groove, the, a condenser pipe is arranged above the rack on one side of the distillation flask, support frames are arranged on two outer side walls of the condenser pipe, the bottom end of each support frame is connected with the bottom end of the rack, a distillation pipe is arranged at the central position inside the condenser pipe, a liquid inlet is arranged at the central position at the top end of the condenser pipe, the bottom end of the liquid inlet is communicated with the top end of the distillation pipe through a guide pipe, the top end of the liquid inlet extends to the inside of the liquid injection port through the guide pipe, a liquid outlet is arranged at the central position at the bottom end of the condenser pipe, the top end of the liquid outlet is communicated with the bottom end of the distillation pipe through the guide pipe, a water inlet is arranged on the outer wall on one side of the condenser pipe, a water outlet is arranged on the outer wall on one side of the condenser pipe, one end of the water outlet extends to, the top of receiving the jar is linked together through the bottom of pipe with the liquid outlet, and the one end that condenser pipe was kept away from to liquid outlet and inlet all is equipped with seal structure, installs control panel on the outer wall of cupping jar one side is kept away from to the frame, the input of the inside singlechip of control panel and the output electric connection of thermometer.

Preferably, the inside of seal structure is equipped with first clamp splice, sealing ring, locking bolt, lock nut and second clamp splice in proper order, all install the sealing ring on two lateral walls that condenser pipe one end was kept away from to inlet and liquid outlet, and be fixed with first clamp splice and second clamp splice on the outer wall of sealing ring both sides respectively to carry out sealed processing to inlet and liquid outlet.

Preferably, a locking nut is fixed on the outer wall of one side, away from the first clamping block, of the second clamping block, a locking bolt is arranged on the outer wall of one side, away from the second clamping block, of the first clamping block, one end of the locking bolt sequentially penetrates through the first clamping block and the second clamping block and is in threaded connection with the locking nut, and therefore the sealing ring is tightly attached to the outer walls of the liquid inlet and the liquid outlet.

Preferably, the central position of the surface of the distillation bottle is sleeved with a sleeve frame, and one end of the sleeve frame is connected with the outer wall of the rack so as to fix the distillation bottle to the top of the bearing frame.

Preferably, a placing plate is fixed on the outer wall of the rack above the distillation flask, a vacuum pump is installed on one side of the top end of the placing plate, one end of the vacuum pump extends into the distillation flask through a guide pipe, and a pressure gauge is installed on the outer wall of one side of the distillation flask, so that the inside of the distillation flask is subjected to reduced pressure treatment.

Preferably, the screw rod surface thread connection below placing the platform has the screw cap, and the top of screw rod is fixed with the spacing dish to the interval between cupping jar and the retort of adjusting.

Compared with the prior art, the beneficial effects of the utility model are that: the reduced pressure distillation device for the 4-methoxy methyl acetoacetate crude product not only improves the distillation effect when the distillation device is used, improves the convenience when the distillation device is used, but also reduces the phenomenon of leakage when the distillation device is used;

(1) through being provided with the manometer, place board and vacuum pump, place the vacuum pump that the board top set up through operation control panel control, make it take out to the air in the retort, and then make the inside atmospheric pressure of retort obtain reducing, the manometer scale can monitor the atmospheric pressure value in the retort simultaneously, relevant data can feed back to control panel, so as to carry out the closure processing to the vacuum pump, the decompression function of distillation plant has been realized, and then the boiling point of waiting for the extract product has been reduced, and make its vaporization efficiency promote, thereby the distillation effect when having improved distillation plant use;

(2) the screw cap is arranged on the surface of the screw rod to move upwards by rotating the screw cap, the top of the screw rod is positioned in the lifting through groove to move downwards, and meanwhile, the screw rod is limited by the limiting disc to be prevented from being separated from the lifting through groove, so that the distance between the placing table and the rack is increased, the distance between the fire pot and the distillation flask is adjusted according to specific distillation requirements, and the convenience of the distillation device in use is improved;

(3) through being provided with first clamp splice, sealing ring, locking bolt, lock nut and second clamp splice, through rotatory locking bolt, make it in proper order through the inside and screw in to lock nut's inside of first clamp splice and second clamp splice, two sets of sealing rings then can closely laminate in the contact position department of inlet and liquid outlet and pipe this moment to carry out sealing treatment to inlet and liquid outlet, thereby produced the phenomenon of leaking when having reduced distillation plant and using.

Drawings

Fig. 1 is a schematic front view of a cross-sectional structure of the present invention;

fig. 2 is an enlarged schematic structural view of a point a in fig. 1 according to the present invention;

FIG. 3 is a schematic view of the seal structure of the present invention in cross section and enlarged structure;

fig. 4 is a schematic view of the seal ring of the present invention showing an enlarged structure from above.

In the figure: 1. a frame; 2. a control panel; 3. a cupping jar; 4. a carrier; 5. sleeving a frame; 6. a pressure gauge; 7. placing the plate; 8. a vacuum pump; 9. a thermometer; 10. a sealing plug; 11. a liquid injection port; 12. a sealing structure; 1201. a first clamping block; 1202. a seal ring; 1203. locking the bolt; 1204. locking the nut; 1205. a second clamp block; 13. a liquid inlet; 14. a water inlet; 15. a distillation tube; 16. a condenser tube; 17. a support frame; 18. a receiving tank; 19. a liquid outlet; 20. a water outlet; 21. a distillation flask; 22. a screw cap; 23. a screw rod; 24. a placing table; 25. a limiting disc; 26. go up and down to lead to the groove.

Detailed Description

The technical solutions in the embodiments of the present invention will be described clearly and completely with reference to the accompanying drawings in the embodiments of the present invention, and it is obvious that the described embodiments are only some embodiments of the present invention, not all embodiments. Based on the embodiments in the present invention, all other embodiments obtained by a person skilled in the art without creative work belong to the protection scope of the present invention.

Referring to fig. 1-4, the present invention provides an embodiment: a4-methoxy methyl acetoacetate crude product reduced pressure distillation plant, including frame 1, cupping jar 3, condenser pipe 16, receiving tank 18 and distillation flask 21, the upper portion of frame 1 is equipped with cupping jar 3, and install bearing frame 4 on the frame 1 outer wall above cupping jar 3, and the central point department of bearing frame 4 top has placed distillation flask 21, the central point department on distillation flask 21 surface is equipped with set frame 5, one end of set frame 5 is connected with the outer wall of frame 1, so that fix distillation flask 21 to the top of bearing frame 4;

a placing plate 7 is fixed on the outer wall of the rack 1 above the distillation flask 21, a vacuum pump 8 is installed on one side of the top end of the placing plate 7, the type of the vacuum pump 8 can be XD-RA0302D, one end of the vacuum pump 8 extends into the distillation flask 21 through a guide pipe, the input end of the vacuum pump 8 is electrically connected with the output end of the single chip microcomputer in the control panel 2, a pressure gauge 6 is installed on the outer wall of one side of the distillation flask 21, the type of the pressure gauge 6 can be PT124G-111, and the output end of the pressure gauge 6 is electrically connected with the input end of the single chip microcomputer in the control panel 2 so as to perform pressure reduction treatment on the interior of the distillation flask 21;

a liquid injection port 11 is arranged at the center of the top end of the distillation flask 21, the bottom end of the liquid injection port 11 extends into the distillation flask 21, a sealing plug 10 is mounted at the top of the liquid injection port 11, the top end of the sealing plug 10 extends to the outside of the liquid injection port 11, a thermometer 9 is mounted at the center of the top end of the sealing plug 10, the type of the thermometer 9 can be PT100, the bottom end of the thermometer 9 extends into the liquid injection port 11, a placing table 24 is arranged below the fire pot 3, a screw cap 22 is connected to the surface of a screw rod 23 below the placing table 24 in a threaded manner, and a limiting disc 25 is fixed at the top end of the screw rod 23 so as to adjust the distance between the fire pot 3 and the;

a lifting through groove 26 is arranged at the central position of the bottom of the placing table 24, a screw rod 23 is arranged at the central position inside the lifting through groove 26, the bottom end of the screw rod 23 extends to the outside of the lifting through groove 26 and is fixedly connected with the bottom of the rack 1, a condenser pipe 16 is arranged above the rack 1 at one side of the distillation flask 21, two outer side walls of the condenser pipe 16 are both provided with a support frame 17, the bottom end of the support frame 17 is connected with the bottom of the rack 1, a distillation pipe 15 is arranged at the central position inside the condenser pipe 16, a liquid inlet 13 is arranged at the central position of the top end of the condenser pipe 16, the bottom end of the liquid inlet 13 is communicated with the top end of the distillation pipe 15 through a guide pipe, the top end of the liquid inlet 13 extends to the inside of the liquid injection port 11 through a guide pipe, a liquid outlet 19 is arranged at the central position of the, a water inlet 14 is formed in the outer wall of one side of the condensation pipe 16, one end of the water inlet 14 extends into the condensation pipe 16, a water outlet 20 is formed in the outer wall of one side, away from the water inlet 14, of the condensation pipe 16, one end of the water outlet 20 extends into the condensation pipe 16, a receiving tank 18 is placed at the bottom of the rack 1 of one side, away from the fire pot 3, of the supporting frame 17, the top end of the receiving tank 18 is communicated with the bottom end of the liquid outlet 19 through a conduit, and therefore distilled liquid can be collected and processed;

sealing structures 12 are arranged at one ends, far away from the condenser tube 16, of the liquid outlet 19 and the liquid inlet 13, the sealing structures 12 are internally provided with a first clamping block 1201, a sealing ring 1202, a locking bolt 1203, a locking nut 1204 and a second clamping block 1205 in sequence, the sealing rings 1202 are arranged on two outer side walls, far away from one end of the condenser tube 16, of the liquid inlet 13 and the liquid outlet 19, the first clamping block 1201 and the second clamping block 1205 are fixed on outer walls of two sides of the sealing rings 1202 respectively, the locking nut 1204 is fixed on an outer wall, far away from one side of the first clamping block 1201, of the outer wall, far away from one side of the second clamping block 1205, of the first clamping block 1201 is provided with the locking bolt 1203, and one end of the locking bolt 1203 penetrates through the first clamping block 1201 and the second clamping block 1205 in sequence and is in;

the locking bolt 1203 is rotated to sequentially pass through the interiors of the first clamping block 1201 and the second clamping block 1205 and be screwed into the interior of the locking nut 1204, and at the moment, the two groups of sealing rings 1202 are tightly attached to the contact positions of the liquid inlet 13 and the liquid outlet 19 with the guide pipe, so that the liquid inlet 13 and the liquid outlet 19 are sealed, and the phenomenon of leakage generated when the distillation device is used is reduced;

the outer wall of the frame 1 far away from the side of the cupping jar 3 is provided with a control panel 2, the model of the control panel 2 can be GC-1, and the input end of a singlechip in the control panel 2 is electrically connected with the output end of the thermometer 9.

The working principle is as follows: when the distillation device is used, firstly, the extract to be extracted is injected into the distillation flask 21 from the liquid injection port 11, then the sealing plug 10 is installed at the top of the liquid injection port 11 for sealing treatment, the screw cap 22 is rotated to be positioned on the surface of the screw rod 23 to move upwards, the top of the screw rod 23 is positioned inside the lifting through groove 26 to move downwards, meanwhile, the screw rod 23 is limited by the limiting disc 25 to avoid being separated from the inside of the lifting through groove 26, further, the distance between the placing table 24 and the rack 1 is lifted, so that the distance between the fire pot 3 and the distillation flask 21 is adjusted according to specific distillation requirements, the convenience of the distillation device in use is improved, then, the fire pot 3 is ignited to heat the extract to be extracted inside the distillation flask 21, then, the vacuum pump 8 arranged at the top end of the placing plate 7 is controlled by the operation control panel 2 to pump the air inside the distillation flask 21, so that the air pressure inside the distillation flask 21 is reduced, meanwhile, the pressure gauge 6 monitors the air pressure inside the distillation flask 21, the related data is fed back to the control panel 2, so as to close the vacuum pump 8, thereby realizing the pressure reduction function of the distillation apparatus, further reducing the boiling point of the extract to be extracted, and improving the vaporization efficiency, thereby improving the distillation effect when the distillation apparatus is used, at this time, the distilled liquid flows into the distillation tube 15 through the liquid inlet 13, then the water source is injected through the water inlet 14, so that the liquid inside the distillation tube 15 is cooled, due to the circulation effect of the water outlet 20, the water source inside the condensation tube 16 can flow out through the water outlet 20, then the liquid inside the distillation tube 15 flows into the receiving tank 18 through the liquid outlet 19 for collection, and finally, the locking bolt 1203 is rotated to sequentially pass through the insides of the first clamping block 1201 and the second clamping block 1205 and screwed into the locking nut 1204, at this time, the two sets of sealing rings 1202 are tightly attached to the contact positions of the liquid inlet 13 and the liquid outlet 19 with the conduit, so as to seal the liquid inlet 13 and the liquid outlet 19, thereby reducing the leakage phenomenon generated during the use of the distillation apparatus, and completing the use of the distillation apparatus.

It is obvious to a person skilled in the art that the invention is not restricted to details of the above-described exemplary embodiments, but that it can be implemented in other specific forms without departing from the spirit or essential characteristics of the invention. The present embodiments are therefore to be considered in all respects as illustrative and not restrictive, the scope of the invention being indicated by the appended claims rather than by the foregoing description, and all changes which come within the meaning and range of equivalency of the claims are therefore intended to be embraced therein. Any reference sign in a claim should not be construed as limiting the claim concerned.

Claims

1. The utility model provides a 4-methoxy methyl acetoacetate crude vacuum distillation plant, includes frame (1), cupping jar (3), condenser pipe (16), receives jar (18) and distillation flask (21), its characterized in that: a fire pot (3) is arranged above the rack (1), a bearing frame (4) is arranged on the outer wall of the rack (1) above the fire pot (3), a distillation flask (21) is placed at the central position of the top end of the bearing frame (4), a liquid injection port (11) is arranged at the central position of the top end of the distillation flask (21), the bottom end of the liquid injection port (11) extends into the distillation flask (21), a sealing plug (10) is arranged at the top of the liquid injection port (11), the top end of the sealing plug (10) extends to the outside of the liquid injection port (11), a thermometer (9) is arranged at the central position of the top end of the sealing plug (10), the bottom end of the thermometer (9) extends into the inside of the liquid injection port (11), a placing table (24) is arranged below the fire pot (3), a lifting through groove (26) is arranged at the central position of the bottom of the placing table (24), and a screw rod (23) is arranged at the central, the bottom of lead screw (23) extends to the outside of going up and down through groove (26) and with the bottom fixed connection of frame (1), frame (1) top of retort (21) one side is equipped with condenser pipe (16), and all installs support frame (17) on two lateral walls of condenser pipe (16), the bottom of support frame (17) is connected with the bottom of frame (1), and the inside central point department of condenser pipe (16) is equipped with distillation column (15), the central point department of condenser pipe (16) top is equipped with inlet (13), the bottom of inlet (13) is linked together through the top of pipe and distillation column (15), the top of inlet (13) extends to the inside of annotating liquid mouth (11) through the pipe, and the central point department of condenser pipe (16) bottom is equipped with liquid outlet (19), the top of liquid outlet (19) is linked together through the bottom of pipe and distillation column (15), a water inlet (14) is arranged on the outer wall of one side of the condensation pipe (16), one end of the water inlet (14) extends to the inside of the condensation pipe (16), a water outlet (20) is arranged on the outer wall of one side of the condensation pipe (16) far away from the water inlet (14), one end of the water outlet (20) extends to the inside of the condensation pipe (16), a receiving tank (18) is arranged at the bottom of the frame (1) at one side of the supporting frame (17) far away from the cupping jar (3), the top end of the receiving tank (18) is communicated with the bottom end of the liquid outlet (19) through a conduit, and the one end that condenser pipe (16) were kept away from in liquid outlet (19) and inlet (13) all is equipped with seal structure (12), installs control panel (2) on the outer wall of frame (1) one side of keeping away from cupping jar (3), the input of the inside singlechip of control panel (2) and the output electric connection of thermometer (9).

2. The reduced pressure distillation device for the crude product of methyl 4-methoxyacetoacetate according to claim 1, which is characterized in that: the inside of seal structure (12) is equipped with first clamp splice (1201), sealing ring (1202), locking bolt (1203), lock nut (1204) and second clamp splice (1205) in proper order, all install sealing ring (1202) on two lateral walls of inlet (13) and liquid outlet (19) keep away from condenser pipe (16) one end, and be fixed with first clamp splice (1201) and second clamp splice (1205) on the outer wall of sealing ring (1202) both sides respectively.

3. The reduced pressure distillation device for the crude product of methyl 4-methoxyacetoacetate according to claim 2, which is characterized in that: locking nut (1204) are fixed with on the outer wall of second clamp splice (1205) one side of keeping away from first clamp splice (1201), and first clamp splice (1201) are kept away from and are equipped with locking bolt (1203) on the outer wall of second clamp splice (1205) one side, and the one end of locking bolt (1203) runs through first clamp splice (1201) and second clamp splice (1205) in proper order and with locking nut (1204) threaded connection.

4. The reduced pressure distillation device for the crude product of methyl 4-methoxyacetoacetate according to claim 1, which is characterized in that: the central position on the surface of the distillation flask (21) is sleeved with a sleeve frame (5), and one end of the sleeve frame (5) is connected with the outer wall of the rack (1).

5. The reduced pressure distillation device for the crude product of methyl 4-methoxyacetoacetate according to claim 1, which is characterized in that: be fixed with on frame (1) outer wall of retort (21) top and place board (7), and place one side on board (7) top and install vacuum pump (8), the inside that the pipe extended to retort (21) is passed through to the one end of vacuum pump (8) to install manometer (6) on the outer wall of retort (21) one side.

6. The reduced pressure distillation device for the crude product of methyl 4-methoxyacetoacetate according to claim 1, which is characterized in that: the screw cap (22) is connected to the surface of the screw rod (23) below the placing table (24) in a threaded mode, and the limiting disc (25) is fixed to the top end of the screw rod (23).