CN212593518U - Intermediate frequency alternating electric field tumor treatment device - Google Patents
Intermediate frequency alternating electric field tumor treatment device Download PDFInfo
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- CN212593518U CN212593518U CN202020469108.6U CN202020469108U CN212593518U CN 212593518 U CN212593518 U CN 212593518U CN 202020469108 U CN202020469108 U CN 202020469108U CN 212593518 U CN212593518 U CN 212593518U
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Abstract
The utility model discloses a medium frequency alternating electric field tumor treatment device, which belongs to the technical field of medical equipment. The temperature detection circuit comprises a thermistor arranged on the electrode patch, and the signal generation module comprises a direct digital frequency synthesis module, a digital-to-analog converter, an analog synthesis circuit, an active filter circuit and a signal amplification circuit. The device has a temperature detection circuit and a current detection circuit, can effectively collect the working state of equipment, has perfect safety protection function, can output a high-power electric field, and can be used for treating deep tumors.
Description
Technical Field
The utility model relates to the technical field of medical equipment, in particular to a medium-frequency alternating electric field tumor treatment device.
Background
Brain gliomas are malignant tumors derived from neuroepithelial tissues, commonly known as "brain cancers". Brain glioma is the most common intracranial primary tumor, and foreign clinical statistics show that the incidence rate of intracranial primary tumors is 21/10 ten thousand, and glioma accounts for about 60%. Domestic literature reports that brain glioma accounts for about 35.26% -60.96% of intracranial tumors. The most common treatment method at present is surgery and radiotherapy and chemotherapy, and the brain glioma grows infiltratively, so the surgery is often difficult to completely cut. And because the tumor is a radiation-resistant tumor and is resistant to most chemotherapeutics, the overall curative effect is poor, especially high-grade glioma has the growth characteristics of high degree anaplasia, the postoperative recurrence is fast, the prognosis is poor, and the health of human beings is seriously threatened.
Tumor treating electric fields (tumor treating fields) have a good effect on tumor treatment by interfering with the mitotic process of destroying cells. Currently, only NOVOTTF-100A medium frequency alternating electric field tumor treatment equipment developed by NoVokule (Novocure) limited company is used clinically, and no related mature products are on the market at home.
The existing medium-frequency alternating electric field tumor treatment equipment has the following problems:
1. the electric field intensity generated by the existing equipment is weak, and the equipment can only be used for treating superficial tumors and is not suitable for treating deep tumors.
2. The electrode patch can generate heat in the treatment process, so that the risk of scalding a patient is high, and the average service life of the electrode patch is shortened.
3. The problem of overlarge output current can occur when the existing equipment works abnormally, and the human health can be possibly damaged.
SUMMERY OF THE UTILITY MODEL
In view of this, the utility model provides a medium frequency alternating electric field tumor therapy device, the device is applicable in the treatment of deep tumour to have the function of safety protection.
In order to realize the purpose, the utility model discloses a technical scheme is:
an intermediate frequency alternating electric field tumor treatment device comprises an electrode patch, a working circuit, a temperature detection circuit and a current detection circuit, wherein the working circuit comprises a power module, a control module, a signal generation module and a power amplification module; the power supply module is used for providing power for the working circuit, the control module outputs reference frequency to the direct digital frequency synthesis module and outputs a digital signal for amplitude modulation to the digital-to-analog converter, the direct digital frequency synthesis module generates an intermediate frequency analog signal according to the reference frequency, the analog synthesis circuit synthesizes the intermediate frequency analog signal and the analog signal output by the digital-to-analog converter to generate an intermediate frequency signal with required amplitude, the active filter circuit filters the intermediate frequency signal output by the analog-to-digital converter, the signal amplification circuit amplifies the signal output by the active filter circuit, and the power amplification module amplifies the signal output by the signal amplification circuit in power and transmits the signal to the electrode patch; the temperature detection circuit senses the temperature of the electrode patch through the thermistor and feeds a temperature detection signal back to the control module, and the current detection circuit is used for detecting the signal current output by the power amplification module and feeding a current detection signal back to the control module.
Furthermore, in the temperature detection circuit, one end of the thermistor is grounded, the other end of the thermistor is connected with a 3V power supply through a first RC filter, and is connected with the positive input end of the operational amplifier through a second RC filter, the positive input end of the operational amplifier is also connected with a 5V power supply through an LC filter, the output end of the operational amplifier is connected to the control module through a third RC filter, and the negative input end of the operational amplifier is grounded and is connected to the output end of the operational amplifier through a resistor; the second RC filter and the third RC filter are respectively connected with a protection circuit in parallel, and the protection circuit is a pair of voltage stabilizing diodes which are connected in series in an opposite direction.
Furthermore, the output end of the power amplification module is connected in series with a sampling resistor; the current detection circuit comprises an isolation operational amplifier, a subtracter and an effective value chip, wherein two ends of the sampling resistor are connected with the isolation operational amplifier through a filter circuit, the isolation operational amplifier generates 8 times of amplified signals and outputs the amplified signals to the subtracter to further amplify the sine alternating current signals, and the effective value chip converts the amplified sine alternating current signals into stable direct current signals and feeds the stable direct current signals back to the control module.
Furthermore, a voltage limiting protection circuit is connected between two ends of the sampling resistor, the output end of the effective value chip is also connected with the voltage limiting protection circuit, and the voltage limiting protection circuit is a pair of voltage stabilizing diodes which are reversely connected in series.
Compared with the prior art, the utility model following beneficial effect has:
1. the utility model discloses in, the signal of signal generation module output is not directly provided for the electrode paster, but gives the electrode paster again after the amplification of power amplification module to can effectively promote the intensity of treatment electric field, have the ability of treatment deep tumour.
2. The utility model discloses the device has further set up temperature detection circuit and current detection circuit, and the operating condition that can effectively monitor device cooperates corresponding control program, can in time handle the too high, too big circumstances such as current output of electrode temperature, has protected user's personal safety effectively, has improved the security of device.
Drawings
Fig. 1 is a schematic block diagram of a medium frequency alternating electric field tumor therapy device in an embodiment of the present invention.
Fig. 2 and fig. 3 are a schematic block diagram and an electrical schematic diagram of a signal generating module according to an embodiment of the present invention.
Fig. 4 and 5 are a schematic block diagram and an electrical schematic diagram of a temperature detection circuit according to an embodiment of the present invention.
Fig. 6 and 7 are a schematic block diagram and an electrical schematic diagram of a current detection circuit according to an embodiment of the present invention.
Detailed Description
The present invention will be described in further detail with reference to the accompanying drawings.
As shown in fig. 1, the intermediate frequency alternating electric field tumor treatment device comprises an electrode patch, a working circuit, a temperature detection circuit and a current detection circuit, wherein the working circuit comprises a power module, a control module, a signal generation module and a power amplification module, and the temperature detection circuit comprises a thermistor arranged on the electrode patch. Wherein:
the structure of the power amplifying module is common knowledge and will not be described herein.
The power module includes:
1. a power management module:
1) converting commercial power input through an adapter into a 12VDC power supply to be respectively supplied to a control host module, a DC-DC module and a rechargeable battery;
2) and the 12VDC power output by the rechargeable battery is respectively supplied to the control host module and the DC-DC module.
2. A DC-DC module: and converting the 12VDC power output by the power management module into +/-36 VDC power to be supplied to the power amplification module.
3. Charging a battery:
1) when the mains supply is connected, the 12VDC power output by the power management module is stored;
2) when the commercial power is not connected, outputting a 12VDC power supply to the power management module;
3) the voltage feedback signal is transmitted to the control host module, and the electric quantity condition of the rechargeable battery is monitored in real time;
4) the battery protection function is provided, battery damage caused by overshoot, overdischarge and the like is prevented, and the service life of the battery is prolonged.
As shown in fig. 2 and 3, the signal generating module includes a direct digital frequency synthesis module, a digital-to-analog converter, an analog synthesis circuit, a 4-order active filter circuit, and a signal amplifying circuit; the power supply module is used for providing power for the working circuit, the control module outputs reference frequency to the direct digital frequency synthesis module and outputs a digital signal for amplitude modulation to the digital-to-analog converter, the direct digital frequency synthesis module generates an intermediate frequency analog signal according to the reference frequency, the analog synthesis circuit synthesizes the intermediate frequency analog signal and the analog signal output by the digital-to-analog converter to generate an intermediate frequency signal with required amplitude, the 4-order active filter circuit filters the intermediate frequency signal output by the analog synthesis circuit, the signal amplification circuit amplifies the signal output by the 4-order active filter circuit, and the power amplification module amplifies the power of the signal output by the signal amplification circuit and transmits the signal to the electrode patch; the temperature detection circuit senses the temperature of the electrode patch through the thermistor and feeds a temperature detection signal back to the control module, and the current detection circuit is used for detecting the signal current output by the power amplification module and feeding a current detection signal back to the control module.
As shown in fig. 4 and 5, in the temperature detection circuit, one end of the thermistor is grounded, the other end of the thermistor is connected to the 3V power supply through the first RC filter, and is connected to the positive input end of the operational amplifier through the second RC filter, the positive input end of the operational amplifier is also connected to the 5V power supply through the LC filter, the output end of the operational amplifier is connected to the control module through the third RC filter, and the negative input end of the operational amplifier is grounded and is connected to the output end of the operational amplifier through a resistor; the second RC filter and the third RC filter are respectively connected with a protection circuit in parallel, and the protection circuit is a pair of voltage stabilizing diodes which are connected in series in an opposite direction.
The temperature detection circuit has the following advantages:
1) the stability is high.
a. Based on the reverse voltage-current characteristic of the voltage regulator diode, when the reverse voltage is lower than the reverse breakdown voltage, the reverse resistance is large, and the reverse leakage current is extremely small. However, when the reverse voltage approaches the threshold value of the reverse voltage, the reverse current suddenly increases, i.e., breaks down. Therefore, a pair of voltage stabilizing diodes are reversely connected in series to form a protection module, and the protection module can play an overvoltage protection role on a circuit connected in parallel with the voltage stabilizing diodes.
b. A plurality of filter circuits are adopted, so that the input signal, the output signal and the output voltage of each power supply are stabilized.
c. The current source is adopted to replace the traditional power supply, the internal resistance of the current source is very large relative to the load impedance, the influence of the fluctuation of the load impedance on the current magnitude is not obvious, constant current can be output, and the stability of the whole circuit is improved.
2) High precision and high temperature induction speed.
The high-precision thermistor is selected, so that the temperature sensor has the characteristics of good stability, high resistance precision, small volume, light weight, high thermal sensing speed, high sensitivity and the like, and the temperature can be accurately measured.
3) The power consumption is low.
The output voltage of the power supply A, B is low, and the power consumption of the whole temperature detection circuit is greatly reduced by adopting the operational amplifier with low power consumption.
The output end of the power amplification module is connected with a sampling resistor in series; as shown in fig. 6 and 7, the current detection circuit includes an isolation operational amplifier, a subtractor, and an effective value chip, wherein both ends of the sampling resistor are connected to the isolation operational amplifier through a filter circuit, the isolation operational amplifier generates an 8-fold amplification signal and outputs the signal to the subtractor to further amplify the sinusoidal ac signal, and the effective value chip converts the amplified sinusoidal ac signal into a stable dc signal and feeds the stable dc signal back to the control module.
Furthermore, a voltage limiting protection circuit is connected between two ends of the sampling resistor, the output end of the effective value chip is also connected with the voltage limiting protection circuit, and the voltage limiting protection circuit is a pair of voltage stabilizing diodes which are reversely connected in series.
The device has the following advantages:
1) and outputting an alternating current signal with medium frequency and high power. Through the signal generation module and the power amplification module, the alternating current signals with the frequency of 100 plus and minus 70V and the effective value of 2A can be output, and an alternating electric field is generated for treating the deep tumor.
2) The stability is good.
a. On the premise of meeting system performance and function indexes, the system structure is designed in a simplified manner, and the possibility of system failure caused by excessive component elements is avoided being increased;
b. in the feedback circuit, a small resistor or a choke coil is adopted outside the feedback loop to provide a buffer for a capacitive load so as to improve the stability of the circuit;
c. and filtering is arranged at the wire connection position without the shielding system.
3) The anti-interference capability is strong. The 4-order active filter circuit adopted in the signal generation module can effectively inhibit interference and obtain flat response characteristics.
4) And the power consumption is low.
a. And a singlechip with low power consumption is used as a core of the control host module. Meanwhile, on the premise of meeting the performance requirement, a low-power-consumption component is selected, so that the overall power consumption of the circuit is reduced;
b. in a treatment state, the high-power components normally operate; in the non-treatment state, the high-power component stops running temporarily, so that the power consumption of the high-power component can be reduced.
A more specific example is as follows:
the utility model provides an intermediate frequency alternating electric field tumour treatment device, includes electrode paster and working circuit, in addition, still includes electrode temperature detect circuit, power amplifier temperature detect circuit, current detection circuit and fan, and electrode temperature detect circuit and power amplifier temperature detect circuit's structure is the same. Wherein:
the working circuit comprises a power supply module, a control module, a signal generation module and a power amplification module, the fan dissipates heat for the power amplification module, the electrode temperature detection circuit comprises a thermistor arranged on an electrode patch, the power amplification temperature detection circuit comprises a thermistor arranged on the power amplification module, and the signal generation module comprises a direct digital frequency synthesis module, a digital-to-analog converter, an analog synthesis circuit, a 4-order active filter circuit and a signal amplification circuit; the power supply module is used for providing power for the working circuit, the control module outputs reference frequency to the direct digital frequency synthesis module and outputs a digital signal for amplitude modulation to the digital-to-analog converter, the direct digital frequency synthesis module generates an intermediate frequency analog signal according to the reference frequency, the analog synthesis circuit synthesizes the intermediate frequency analog signal and the analog signal output by the digital-to-analog converter to generate an intermediate frequency signal with required amplitude, the 4-order active filter circuit filters the intermediate frequency signal output by the analog synthesis circuit, the signal amplification circuit amplifies the signal output by the 4-order active filter circuit, and the power amplification module amplifies the power of the signal output by the signal amplification circuit and transmits the signal to the electrode patch; the electrode temperature detection circuit senses the temperature of the electrode patch through a corresponding thermistor and feeds back a corresponding temperature detection signal to the control module, the power amplifier temperature detection circuit senses the temperature of the power amplification module through a corresponding thermistor and feeds back a corresponding temperature detection signal to the control module, and the current detection circuit is used for detecting the current of a signal output by the power amplification module and feeding back the current detection signal to the control module;
in the electrode temperature detection circuit and the power amplifier temperature detection circuit, one end of a thermistor is grounded, the other end of the thermistor is connected with a 3V power supply through a first RC filter, and is connected with the positive input end of an operational amplifier through a second RC filter, the positive input end of the operational amplifier is also connected with a 5V power supply through an LC filter, the output end of the operational amplifier is connected to the control module through a third RC filter, and the negative input end of the operational amplifier is grounded and is connected to the output end of the operational amplifier through a resistor; the second RC filter and the third RC filter are respectively connected with a protection circuit in parallel, and the protection circuit is a pair of voltage stabilizing diodes which are connected in series in an opposite direction;
the output end of the power amplification module is connected with a sampling resistor in series; the current detection circuit comprises an isolation operational amplifier, a subtracter and an effective value chip, wherein two ends of the sampling resistor are connected with the isolation operational amplifier through a filter circuit, the isolation operational amplifier generates 8 times of amplified signals and outputs the amplified signals to the subtracter to further amplify the sine alternating current signals, and the effective value chip converts the amplified sine alternating current signals into stable direct current signals and feeds the stable direct current signals back to the control module;
the control module executes the following control actions according to the temperature T1 fed back by the electrode temperature detection circuit, the temperature T2 fed back by the power amplifier temperature detection circuit and the signal I fed back by the current detection circuit:
(1) when the temperature T2 is more than 40 ℃, the fan is controlled to be turned on, and when the temperature T2 is less than or equal to 40 ℃, the fan is controlled to be turned off;
(2) when the condition is met, the output voltage of the power amplification module is gradually increased from the lowest voltage to the highest voltage step by controlling the size of a signal output to the digital-to-analog converter, and is gradually decreased to the lowest voltage step by step after the highest voltage is kept for a period of time, so that the operation is performed in a periodic manner;
(3) when the condition two is met and the condition one is not met, the current output voltage of the power amplification module is gradually reduced to the lowest voltage by controlling the size of a signal output to the digital-to-analog converter;
(4) when the condition three is met and the condition two is not met, the output voltage of the power amplification module is directly reduced to the lowest voltage by controlling the size of a signal output to the digital-to-analog converter;
(5) when the condition four is met, the current output voltage of the power amplification module is reduced by one level by controlling the size of a signal output to the digital-to-analog converter;
(6) when the condition five is met, stopping outputting the signal to the digital-to-analog converter;
(7) when I is detected to be less than or equal to 100mA or T2 is detected to be less than or equal to 38 ℃ under the highest voltage, the fault of the device is prompted;
wherein the first condition is as follows: t1 is more than 25 ℃ and less than 40 ℃, and T2 is more than 48 ℃ and less than 60 DEG C
The second condition is as follows: t1 < 42 ℃ at 25 ℃ and T2 < 70 ℃ at 48 DEG C
The third condition is as follows: t1 < 43 ℃ at 25 ℃ and T2 < 80 ℃ at 48 DEG C
The fourth condition is: i > 900mA
The fifth condition is as follows: t1 > 43 ℃, T2 > 80 ℃, or I > 1200 mA.
Further, the lowest voltage is 50V, the highest voltage is 128V, and each stage is increased/decreased by 6V; in the cyclic operation, the voltage was raised to the maximum voltage and then held for 7 minutes, and in addition, the voltage was held for 0.5 minute at each stage.
Furthermore, a voltage limiting protection circuit is connected between two ends of the sampling resistor, the output end of the effective value chip is also connected with the voltage limiting protection circuit, and the voltage limiting protection circuit is a pair of voltage stabilizing diodes which are reversely connected in series.
In the above embodiment, the control module may adopt a single chip microcomputer of which the model is STM32F103VET6, and all control actions of the control module can be realized by simple programming known to those skilled in the art, which is not described herein again. In addition, in the current detection circuit, the isolation operational amplifier can adopt a precise isolation amplifier with the model of AMC1300B, and the effective value chip can adopt a high-precision direct current converter with the model of AD637 JRZ. The current detection circuit can convert an intermediate frequency signal of 100k-300kHz into a stabilized direct current signal.
In a word, the device has a temperature detection circuit and a current detection circuit, can effectively collect the working state of equipment, has a perfect safety protection function, can output a high-power electric field, and can be used for treating deep tumors.
It should be noted that the above embodiments are only specific examples of the implementation schemes of this patent, and do not cover all the implementation schemes of this patent, and therefore, the scope of protection of this patent cannot be considered as limited; all the implementations which belong to the same concept as the above cases or the combination of the above schemes are within the protection scope of the patent.
Claims (4)
1. An intermediate frequency alternating electric field tumor treatment device comprises an electrode patch and a working circuit, and is characterized by further comprising a temperature detection circuit and a current detection circuit, wherein the working circuit comprises a power module, a control module, a signal generation module and a power amplification module; the power supply module is used for providing power for the working circuit, the control module outputs reference frequency to the direct digital frequency synthesis module and outputs a digital signal for amplitude modulation to the digital-to-analog converter, the direct digital frequency synthesis module generates an intermediate frequency analog signal according to the reference frequency, the analog synthesis circuit synthesizes the intermediate frequency analog signal and the analog signal output by the digital-to-analog converter to generate an intermediate frequency signal with required amplitude, the active filter circuit filters the intermediate frequency signal output by the analog-to-digital converter, the signal amplification circuit amplifies the signal output by the active filter circuit, and the power amplification module amplifies the signal output by the signal amplification circuit in power and transmits the signal to the electrode patch; the temperature detection circuit senses the temperature of the electrode patch through the thermistor and feeds a temperature detection signal back to the control module, and the current detection circuit is used for detecting the signal current output by the power amplification module and feeding a current detection signal back to the control module.
2. The device as claimed in claim 1, wherein in the temperature detection circuit, one end of the thermistor is grounded, the other end of the thermistor is connected to a 3V power supply through a first RC filter, and is connected to the positive input end of the operational amplifier through a second RC filter, the positive input end of the operational amplifier is further connected to a 5V power supply through an LC filter, the output end of the operational amplifier is connected to the control module through a third RC filter, and the negative input end of the operational amplifier is grounded and is connected to the output end of the operational amplifier through a resistor; the second RC filter and the third RC filter are respectively connected with a protection circuit in parallel, and the protection circuit is a pair of voltage stabilizing diodes which are connected in series in an opposite direction.
3. The medium frequency alternating electric field tumor therapy device according to claim 1, wherein the output end of the power amplification module is connected in series with a sampling resistor; the current detection circuit comprises an isolation operational amplifier, a subtracter and an effective value chip, wherein two ends of the sampling resistor are connected with the isolation operational amplifier through a filter circuit, the isolation operational amplifier generates 8 times of amplified signals and outputs the amplified signals to the subtracter to further amplify the sine alternating current signals, and the effective value chip converts the amplified sine alternating current signals into stable direct current signals and feeds the stable direct current signals back to the control module.
4. The device as claimed in claim 3, wherein a voltage limiting protection circuit is connected between two ends of the sampling resistor, and the output terminal of the effective value chip is also connected with a voltage limiting protection circuit, wherein the voltage limiting protection circuit is a pair of reverse series connected zener diodes.
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN115970166A (en) * | 2022-12-30 | 2023-04-18 | 江苏海莱新创医疗科技有限公司 | Tumor electric field treatment system, tumor treatment equipment and electrode slice temperature detection method |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN115970166A (en) * | 2022-12-30 | 2023-04-18 | 江苏海莱新创医疗科技有限公司 | Tumor electric field treatment system, tumor treatment equipment and electrode slice temperature detection method |
| CN115970166B (en) * | 2022-12-30 | 2024-03-19 | 江苏海莱新创医疗科技有限公司 | Tumor electric field treatment system, tumor treatment equipment and electrode slice temperature detection method |
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