CN107007933A - Pacemaking generation device - Google Patents
Pacemaking generation device Download PDFInfo
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- CN107007933A CN107007933A CN201710128038.0A CN201710128038A CN107007933A CN 107007933 A CN107007933 A CN 107007933A CN 201710128038 A CN201710128038 A CN 201710128038A CN 107007933 A CN107007933 A CN 107007933A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/18—Applying electric currents by contact electrodes
- A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
- A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
- A61N1/362—Heart stimulators
- A61N1/365—Heart stimulators controlled by a physiological parameter, e.g. heart potential
- A61N1/36514—Heart stimulators controlled by a physiological parameter, e.g. heart potential controlled by a physiological quantity other than heart potential, e.g. blood pressure
- A61N1/36521—Heart stimulators controlled by a physiological parameter, e.g. heart potential controlled by a physiological quantity other than heart potential, e.g. blood pressure the parameter being derived from measurement of an electrical impedance
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- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
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- General Health & Medical Sciences (AREA)
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Abstract
The present invention relates to a kind of pacemaking generation device, impedance value including detection pace-making object and the impedance detection module exported, apply pacemaker impulse to the pacemaker impulse sending module for pacing object, receive initial pacemaker current, calculated according to initial pacemaker current and obtain initial pace-making vector, initial pace-making vector is exported to the first processor of pacemaker impulse sending module, according to the second processor of impedance value and initial pacemaker current output regulation signal, and receive Regulate signal and pace-making vector is adjusted according to Regulate signal, pace-making vector after adjustment is exported to the pace-making boost module of pacemaker impulse sending module；Impedance detection module is connected with second processor, pacemaker impulse sending module is connected with first processor, first processor is connected with second processor, second processor is connected with pace-making boost module, pace-making boost module is connected with pacemaker impulse sending module, can effectively ensure that the electric current and voltage security for being carried in pace-making object.
Description
Technical field
The present invention relates to technical field of medical instruments, more particularly to a kind of pacemaking generation device.
Background technology
Defibrillation monitor has noninvasive pacing function, is frequently necessary to use defibrillation monitor pair in clinical urgency treatment occasion
The patient of bradycardia carries out external noninvasive pacing therapy, and external noninvasive pace-making is different from internal pace-making, and external pace-making is by making
Adhesive type electrode slice, internal circuit produces the electric pulse of some strength and width, and heart is released to by electrode, stimulates the heart
Flesh, reaches the effect for the treatment of.The more internal impedance of external human body chest resistance scope will width, excursion is generally the Ω of 20 Ω~200, examines
Consider the contact impedance of electrode slice and human body, the impedance ranges that can generally pace are the Ω of 20 Ω~750；And it is clinical effective
Boost pulse curent change scope 5mA~200mA.To guarantee the galvanism heart that maximum is exported in the range of maximum impedance
Dirty, the maximum power dissipation of pacing circuitry can reach 30W；And paced under minimum impedance and minimum current, the least work of pacing circuitry
Consume for 0.8W, both differ 29.2W.The controlled parameter of external pace-making includes pacing frequency and pacemaker current, pacing frequency
Approximate range is 30bpm~180bpm, and pacemaker current scope is 5mA~200mA, because the output of pacing circuitry is directly acted on
Human body, therefore the monitoring and control tight to two parameters progress is needed during pace-making, when a failure occurs it, close immediately
Pace-making output, ensures the safety of pace-making object to greatest extent.
Traditional noninvasive pace-making is monitored using processor to pacemaker impulse output, by the timer of processor to rising
Frequency of fighting is clocked and pacemaker current is sampled, and reaches the purpose of control, if now processor break down or
Sample circuit breaks down, and will be unable to accurately be controlled pace-making output, easily pace-making object is damaged.
The content of the invention
Based on this, it is necessary to during for processor fault or sample circuit failure, it is impossible to accurate control pacemaker impulse output,
The problem of causing to damage pace-making object monitors pacemaker impulse by two processors there is provided one kind and exported, effective guarantee
Pace the pacemaking generation device of object security.
A kind of pacemaking generation device, includes the impedance value and the impedance detection module of output of detection pace-making object, applies
Pulse fight to the pacemaker impulse sending module for pacing object, receives initial pacemaker current, obtained according to the calculating of initial pacemaker current
Initial pace-making vector, initial pace-making vector exported to the first processor of pacemaker impulse sending module, according to impedance value and just
The second processor of beginning pacemaker current output regulation signal, and receive Regulate signal and electric according to Regulate signal adjustment pace-making
Press, export the pace-making vector after adjustment to the pace-making boost module of pacemaker impulse sending module；
Impedance detection module is connected with second processor, and pacemaker impulse sending module is connected with first processor, at first
Reason device is connected with second processor, and second processor is connected with pace-making boost module, and pace-making boost module is sent with pacemaker impulse
Module is connected.
Above-mentioned pacemaking generation device, first processor obtains initial pace-making vector according to initial pacemaker current, will initially rise
Voltage output of fighting is to pacemaker impulse sending module, and pacemaker impulse sending module applies pacemaker impulse to pacing object, second processing
The impedance value and initial pacemaker current for the pace-making object that device is detected according to impedance detection module generate Regulate signal to pace-making
Boost module, pace-making boost module adjusts pace-making vector according to the Regulate signal, and the pace-making vector after adjustment is exported to pace-making
Pulse sending module, such pacemaking generation device monitors pacemaker impulse by two processors and exported, and can effectively ensure that and adds
The electric current and voltage security of pace-making object are loaded in, so as to ensure to pace the safety of object.
Brief description of the drawings
Fig. 1 is the structural representation of pacemaking generation device in one embodiment；
Fig. 2 is the structural representation of pacemaking generation device middle impedance detection module in one embodiment；
Fig. 3 is the circuit diagram of pacemaker impulse sending module in pacemaking generation device in one embodiment；
Fig. 4 is the circuit diagram for pacing boost module in one embodiment in pacemaking generation device；
Fig. 5 is the part-structure schematic diagram of pacemaking generation device in one embodiment；
Fig. 6 is the circuit diagram of over-pressed hardware comparison circuit in pacemaking generation device in one embodiment；
Fig. 7 is the part-structure schematic diagram of pacemaking generation device in one embodiment.
Embodiment
In one embodiment, as shown in figure 1, a kind of pacemaking generation device, including detection pace the impedance value of object simultaneously
The impedance detection module 100 of output, applies pacemaker impulse to the pacemaker impulse sending module 200 for pacing object, receives initial rise
Fight electric current, according to initial pacemaker current calculate obtain initial pace-making vector and by the initial pace-making vector export to pace-making arteries and veins
The first processor 300 of sending module 200 is rushed, according to the second processor of impedance value and initial pacemaker current output regulation signal
400, and receive Regulate signal and pace-making vector is adjusted according to Regulate signal and exports the pace-making vector after adjustment to pace-making
The pace-making boost module 500 of pulse sending module 200；
Impedance detection module 100 is connected with second processor 400, pacemaker impulse sending module 200 and first processor 300
Connection, first processor 300 is connected with second processor 400, and second processor 400 is connected with pace-making boost module 500, is paced
Boost module 500 is connected with pacemaker impulse sending module 200.
Wherein, pace-making object refers to the effective object of pacemaking generation device, and the effective object of pacemaking generation device can be
Severe cardiac skip slowly, heart contraction is powerless or patient of cardiac arrest.
Structure in the one embodiment of impedance detection module 100 is as shown in Fig. 2 the carrier wave shaping circuit including being sequentially connected
110th, capacitance coupling circuit 120, differential amplifier circuit 130, bandwidth-limited circuit 140 and filter rectifier 150, at first
Reason device 300 sends the square wave for the 30KHz frequencies that dutycycle is 50%, is shaped as sine wave through carrier wave shaping circuit 110, passes through electricity
Hold termination power 120 to be loaded on human body, then pass through the differential amplification of the signal of 130 pairs of differential amplifier circuit coupling, band logical
The analog-digital converter of first processor 300 is sent into after the filtering of filter circuit 140 and the filter rectification of filter rectifier 150
Carry out sampling processing.To ensure the accuracy of impedance measurement, impedance detection module 100 need to be calibrated, using 2 points of calibrations
Method.
Pacemaker impulse sending module 200 is as shown in figure 3, pace-making vector sample circuit, pace-making object including being sequentially connected
Voltage sampling circuit, constant-current source circuit and pacemaker current sample circuit.Pacemaking generation device receive first host computer instruct into
Enter noninvasive pacing mode, set initial pacemaker current I, according to the pace-making Ω of object maximum impedance 750, set initial pace-making electricity
Press the initial pacemaker current * 750 of PACE_PWR=.According to the initial pacemaker current of setting, the control digital-to-analogue conversion of first processor 300
Device DAC exports constant constant-current source driving voltage VDAC=I* (R5+R6), if risen according to driving voltage now to Low ESR
Object of fighting is paced, and metal-oxide-semiconductor Q3 will bear very big voltage V1, is caused Q3 heatings serious, is increased the hair of pacemaking generation device
Heat and power consumption, carry out real-time sampling to pace-making object voltage V2 during pace-making, are carried out according to the pace-making object voltage of sampling
The adjustment of pace-making vector, pace-making vector PACE_PWR=V1+I* (R5+R6)+V2.According to the special parameter of component, in electric current
In the case of scope is confirmable, to ensure that the pressure drop of Q3 in the normal work of circuit, circuit is confirmable, metal-oxide-semiconductor can be set
Q3 pressure drop is a fixed value V3.It is determined that after Q3 pressure drop, being adjusted to pace-making vector, pace-making vector PACE_PWR=V2
+ I* (R5+R6)+V3 or multiplied by with a fixed coefficient, according to the pace-making object voltage V2 measured in real time, enter to pace-making vector
Mobile state is adjusted, and the voltage for making to be loaded on Q3 is a constant value, can reduce Q3 caloric value, reduces power consumption.
First processor 300 and second processor 400 can be digital signal processors, and digital signal processor is by big
The processor for being used for completing certain signal processing tasks of scale or VLSI chip composition, it is high to adapt to
Gradually grow up the need for fast real time signal processing task, with integrated circuit technique and digital signal processing algorithm
Development, the implementation method of digital signal processor is also being continually changing, and processing function is improved constantly and expanded.
Pace-making boost module 500 is as shown in figure 4, digital regulation resistance circuit, voltage-regulation feedback electricity including being sequentially connected
Road and flyback transformer.Feedback current is adjusted by changing the resistance of digital regulation resistance, so as to change second processor
PWM (Pulse Width Modulation, pulse width modulation) feedback voltage in 400, and then change PWM output duty
Than driving flyback transformer to complete the regulation of pace-making vector finally by PWM controls；First processor 300 passes through IIC
(Inter-Integrated Circuit, IC bus) interface sends corresponding number to digital regulation resistance U4 register
According to changing the resistance value of digital regulation resistance.U3 is a three-terminal voltage-stabilizing diode, and reference edge node voltage is that U3 4 pin are stable
In 2.5V.Pace-making vector provides bias current for voltage-regulator diode, and VFB is the feedback end of PWM controls, pace-making vector PACE_PWR
It is also the output end of flyback transformer simultaneously, pace-making vector regulation circuit is isolated by optocoupler with the PWM feedback ends controlled.It is first
First, initial pace-making vector is obtained according to setup algorithm, first processor passes through past digital regulation resistance according to initial pace-making vector value
Register in corresponding data are write to change the resistance value of digital regulation resistance, and then change the electricity at reference voltage terminal two ends
Resistance, the resistance at reference voltage terminal two ends is Rx, and digital regulation resistance constitutes adjustable current source with R3 resistance.Digital regulation resistance electricity
The change of resistance can cause the change of feedback branch electric current, and then cause PWM control feedback ends VFB change, so as to change PWM's
Dutycycle, finally realizes the regulation of pace-making vector, pace-making vector PACE_PWR=2.5 (Rx+R3)/Rx.
Above-mentioned pacemaking generation device, first processor 300 obtains initial pace-making vector according to initial pacemaker current, will be initial
Pace-making vector is exported to pacemaker impulse sending module 200, and pacemaker impulse sending module 200 exports pacemaker impulse to pacing object,
The impedance value and initial pacemaker current for the pace-making object that second processor 400 is detected according to impedance detection module 100 are generated
Regulate signal is to boost module 500 is paced, and pace-making boost module 500 adjusts pace-making vector according to the Regulate signal, after adjustment
Pace-making vector export to pacemaker impulse sending module 200, such pacemaking generation device passes through two processors monitoring pace-makings
Pulse is exported, and can effectively ensure that the electric current and voltage security for being carried in pace-making object, so as to ensure to pace the safety of object.
In one embodiment, pacemaking generation device is counted respectively using first processor 300 and second processor 400
When, concrete structure block diagram is as shown in figure 5, host computer sends pacing frequency to second processor 400, second processor by serial ports
Pacing frequency is transmitted to first processor 300 by 400 by serial ports, now starts pace-making, and first processor 300 is fixed by inside
When device pacemaker impulse is sent to pacing object by pacemaker impulse sending module 200 according to the pacing frequency of setting, the first processing
Device 300 exports PACE markers while pacemaker impulse is sent by IO (Input/Ouput, input and output) mouth, should
PACE markers capture PACE letters by giving second processor 400, second processor 400 after magnetic coupling isolation circuit 600
Number mark carries out the calculating of PACE frequencies, and is compared obtained frequency is calculated with setpoint frequency, if frequency unanimously if
Expression pacemaking generation device is normal condition, can perform next step action；Second processor control is closed if frequency is inconsistent
The output for pulse module of fighting is shut to stop pace-making, and sends failure code.
In one embodiment, host computer sends the initial pacemaker current set to second processor, and second processor is led to
Cross serial ports and be transmitted to first processor, first processor calculates and obtains initial pace-making vector, while passing through ADC pairs of analog-digital converter
Pace-making vector is sampled, and whether judge pace-making vector is setting value, if not being setting value, first processor control pace-making
Pulse sending module closes pacemaker impulse or sends pace-making abnormal signal to second processor by serial ports, and second processor is closed
Close the output of pace-making vector.Simultaneously by by pace-making vector PACE_PWR by after R7 and R8 partial pressures with fixed reference voltage
VREF forms over-pressed hardware comparison circuit, over-pressed hardware comparison circuit as shown in fig. 6, when over-pressed hardware comparison circuit detects hair
Over-pressed signal is sent during raw overvoltage, the over-pressed signal can be sent to first processor, first processor receives overvoltage letter
Number, control pacemaker impulse sending module closes the output of pacemaker impulse, to stop pace-making；Can also be by isolation optocoupler by overvoltage
Signal feeds back to the power management chip of second processor and pacemaking generation device, second processor control pace-making boost module
The output of pace-making vector is closed, power management chip closes the power supply of pacemaking generation device, to close pace-making output.
In one embodiment, host computer sends initial pacemaker current to second processor, and second processor passes through serial ports
First processor is transmitted to, starts pace-making, second processor is by the feedback sample pacemaker current signal of optocoupler, at first
Reason device is directly sampled to pacemaker current signal.First processor and second processor are adopted with different resistance respectively
Sample, the pacemaker current that first processor and second processor are sampled is contrasted, normal if both are consistent, if both
It is inconsistent, stop pacing and sending failure code.Specifically, pacemaking generation device includes the first current sampling circuit and second
Current sampling circuit, the first current sampling circuit is connected with first processor, and the second current sampling circuit connects with second processor
Connect, the pacemaker current for the second current sampling circuit sampling that second processor be sent can be received by first processor, compares the
The pacemaker current of the pacemaker current of one current sampling circuit and the second current sampling circuit, and export comparative result, when both one
During cause, it is failure to actuate；When both are inconsistent, first processor control pacemaker impulse sending module closes pacemaker impulse output, with
Stop pace-making；The pace-making electricity for the first current sampling circuit sampling that first processor is sent can also be received by second processor
Stream, compares the pacemaker current of the first current sampling circuit and the pacemaker current of the second current sampling circuit, and exports comparative result,
When both are consistent, it is failure to actuate；When both are inconsistent, it is defeated that second processor control pace-making boost module stops pace-making vector
Go out, to stop pace-making.In addition, setting hardware comparator formation current foldback circuit on hardware, pacemaker current is judged,
If excessively stream, the output of pacemaker impulse sending module is closed by the energizing signal of hardware comparator, stops pace-making output.
In one embodiment, pacemaking generation device also include isolation circuit, impedance detection module by isolation circuit with
Second processor is connected.Due to being related to the influence of high voltage and current impulse during pace-making, for reduction interference, it is ensured that impedance
The accuracy of detection module, isolation circuit is powered with isolated form transformer.As shown in fig. 7, isolating transformer passes through LDO
5V and 3.3V voltages are produced after the conversion of (Low Dropout Regulator, low pressure difference linear voltage regulator) change-over circuit for resistance
Anti- detection module is used, and impedance detection module one end is connected with pacing electrode, the impedance detection module other end and analog-digital converter
Connection, second processor is sampled and controlled to analog-digital converter by Serial Peripheral Interface (SPI) through isolation circuit, and sampling is obtained
Pace the impedance signal of object；And the impedance signal of pace-making object is sent to first processor, first processor by serial ports
Impedance signal is made the following judgment：Predetermined threshold value of the obtained impedance value with setting that will sample is contrasted, when higher than default
Highest threshold value when then think that electrode slice comes off, stop pacemaker impulse transmission, think electrode when less than default lowest threshold
Piece short circuit, stops the transmission of pacemaker impulse, if between highest threshold value and lowest threshold, then it is assumed that normal, sends pace-making arteries and veins
Punching.
Each technical characteristic of embodiment described above can be combined arbitrarily, to make description succinct, not to above-mentioned reality
Apply all possible combination of each technical characteristic in example to be all described, as long as however, the combination of these technical characteristics is not deposited
In contradiction, the scope of this specification record is all considered to be.
Embodiment described above only expresses the several embodiments of the present invention, and it describes more specific and detailed, but simultaneously
Can not therefore it be construed as limiting the scope of the patent.It should be pointed out that coming for one of ordinary skill in the art
Say, without departing from the inventive concept of the premise, various modifications and improvements can be made, these belong to the protection of the present invention
Scope.Therefore, the protection domain of patent of the present invention should be determined by the appended claims.
Claims (10)
1. a kind of pacemaking generation device, it is characterised in that the impedance value including detection pace-making object and the impedance detection mould exported
Block, applies pacemaker impulse to the pacemaker impulse sending module for pacing object, receives initial pacemaker current, according to the initial pace-making
Current calculation obtains initial pace-making vector and exports the initial pace-making vector to the first of the pacemaker impulse sending module
Processor, according to the second processor of the impedance value and the initial pacemaker current output regulation signal, and receives described
Regulate signal simultaneously adjusts pace-making vector according to the Regulate signal and exports the pace-making vector after adjustment to the pacemaker impulse
The pace-making boost module of sending module；
The impedance detection module is connected with the second processor, the pacemaker impulse sending module and the first processor
Connection, the first processor is connected with the second processor, and the second processor is connected with the pace-making boost module,
The pace-making boost module is connected with the pacemaker impulse sending module.
2. pacemaking generation device according to claim 1, it is characterised in that the pacemaker impulse sending module is included successively
Pace-making vector sample circuit, pace-making object voltage sampling circuit, constant-current source circuit and the pacemaker current sample circuit of connection.
3. pacemaking generation device according to claim 1, it is characterised in that the pace-making boost module includes being sequentially connected
Digital regulation resistance circuit, voltage-regulation feedback circuit and flyback transformer.
4. pacemaking generation device according to claim 1, it is characterised in that the impedance detection module includes being sequentially connected
Carrier wave shaping circuit, capacitance coupling circuit, differential amplifier circuit, bandwidth-limited circuit and filter rectifier.
5. pacemaking generation device according to claim 1, it is characterised in that the second processor is additionally operable to reception first
The marker that processor is sent, and frequency is obtained according to marker calculating, the frequency and predeterminated frequency are carried out
Compare, when the frequency and the predeterminated frequency are inconsistent, control the pace-making boost module to close output pace-making vector.
6. pacemaking generation device according to claim 1, it is characterised in that also including isolation circuit, the impedance detection
Module is connected by the isolation circuit with the second processor.
7. pacemaking generation device according to claim 1, it is characterised in that also including the first current sampling circuit and second
Current sampling circuit, first current sampling circuit is connected with the first processor, second current sampling circuit with
The second processor connection, the first processor is additionally operable to receive the second current sample electricity that the second processor is sent
The pacemaker current on road, and the pace-making of the pacemaker current and second current sampling circuit of relatively more described first current sampling circuit
Electric current, when the pacemaker current of the pacemaker current and second current sampling circuit of first current sampling circuit is inconsistent
When, the first processor controls the pacemaker impulse sending module to close pacemaker impulse output.
8. pacemaking generation device according to claim 1, it is characterised in that also including the first current sampling circuit and second
Current sampling circuit, first current sampling circuit is connected with the first processor, second current sampling circuit with
The second processor connection, first electric current that the second processor is additionally operable to receive the first processor transmission is adopted
The pacemaker current of sample circuit, and the pacemaker current and second current sampling circuit of relatively more described first current sampling circuit
Pacemaker current, when the pacemaker current of the pacemaker current and second current sampling circuit of first current sampling circuit differs
During cause, the second processor control pace-making boost module closes output pace-making vector.
9. pacemaking generation device according to claim 1, it is characterised in that also including the output overvoltage when detecting overvoltage
The over-pressed hardware comparison circuit of signal, the over-pressed hardware comparison circuit is connected with the first processor, first processing
Device is additionally operable to when receiving the over-pressed signal, controls the pacemaker impulse sending module to close pacemaker impulse output.
10. pacemaking generation device according to claim 1, it is characterised in that the first processor is additionally operable to the institute that samples
Pace-making vector is stated, and when the pace-making vector is not equal to preset value, the first processor controls the pacemaker impulse to send
Module closes the output of pacemaker impulse.
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| Application Number | Priority Date | Filing Date | Title |
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| CN201710128038.0A CN107007933B (en) | 2017-03-06 | 2017-03-06 | Pace-making generating device |
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| Application Number | Priority Date | Filing Date | Title |
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| CN201710128038.0A CN107007933B (en) | 2017-03-06 | 2017-03-06 | Pace-making generating device |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN108939296A (en) * | 2018-06-06 | 2018-12-07 | 广东紫薇星实业有限公司 | A method of for protecting Magnetotherapeutic apparatus power supply circuit over-voltage |
| CN112996557A (en) * | 2018-11-14 | 2021-06-18 | 美敦力公司 | Method and apparatus for reducing current loss in medical devices |
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| WO2005120636A9 (en) * | 2004-06-04 | 2006-05-11 | Medtronic Inc | High frequency atrial burst pacing for improved ventricular rate control during atrial arrhythmia |
| CN102056536A (en) * | 2008-06-06 | 2011-05-11 | 皇家飞利浦电子股份有限公司 | Method and system for maintaining a state in a subject |
| CN105983178A (en) * | 2015-02-02 | 2016-10-05 | 深圳市科曼医疗设备有限公司 | Pace-making generation device |
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| WO2005120636A9 (en) * | 2004-06-04 | 2006-05-11 | Medtronic Inc | High frequency atrial burst pacing for improved ventricular rate control during atrial arrhythmia |
| CN102056536A (en) * | 2008-06-06 | 2011-05-11 | 皇家飞利浦电子股份有限公司 | Method and system for maintaining a state in a subject |
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| CN108939296A (en) * | 2018-06-06 | 2018-12-07 | 广东紫薇星实业有限公司 | A method of for protecting Magnetotherapeutic apparatus power supply circuit over-voltage |
| CN112996557A (en) * | 2018-11-14 | 2021-06-18 | 美敦力公司 | Method and apparatus for reducing current loss in medical devices |
| CN112996557B (en) * | 2018-11-14 | 2024-07-30 | 美敦力公司 | Method and apparatus for reducing current loss in medical devices |
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| CN107007933B (en) | 2021-04-20 |
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