CN212416597U - Nitric oxide independent drug delivery system for treating severe respiratory diseases - Google Patents
Nitric oxide independent drug delivery system for treating severe respiratory diseases Download PDFInfo
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- CN212416597U CN212416597U CN202021451861.9U CN202021451861U CN212416597U CN 212416597 U CN212416597 U CN 212416597U CN 202021451861 U CN202021451861 U CN 202021451861U CN 212416597 U CN212416597 U CN 212416597U
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Abstract
An independent nitric oxide administration system for treating respiratory severe diseases comprises an independent box body, wherein an oxygen inlet, a bottom gas inlet, an NO medicament inlet, an air suction pipe orifice, an NO medicament injection port, an expiration exhaust port, a gas sampling port and a sampling gas exhaust port are arranged on the box body; the box body is also provided with a display panel and an operation button; an oxygen supply pipeline, a bottom gas supply pipeline, a NO medicament supply pipeline, a sampling gas pipeline, an expiration one-way valve and a central processing unit are arranged in the box body; the outer side of the box body is also provided with an air suction pipeline and an air exhaust pipeline. The utility model discloses a drug delivery system can independently and automatic configuration inhale nitric oxide gas concentration, can inhale the lung through patient's breathing process with nitric oxide and helium (or nitrogen gas) mixture. The device has compact structure, strong function, simple and convenient operation and high safety.
Description
Technical Field
The utility model relates to the field of medical equipment, concretely relates to independent drug delivery system of nitric oxide of treatment respiratory type severe disease.
Background
Nitric oxide is an important vasodilator discovered in recent years, and maintains the vascular bed in a relatively relaxed state. The exogenous inhaled low-concentration NO gas has a highly selective pulmonary vasodilation effect, can effectively treat patients with combined diseases such as primary pulmonary arterial hypertension (PH) and Respiratory Distress Syndrome (RDS), and mainly comprises the following diseases: primary pulmonary hypertension, idiopathic neonatal persistent pulmonary hypertension, heart disease complicated with pulmonary arterial hypertension and/or acute respiratory distress, lung disease complicated with acute respiratory distress, congenital diaphragmatic hernia, congenital heart/lung surgery, chronic obstructive pulmonary disease and pulmonary fibrosis, bronchospasm, monopulmonary ventilation complicated with hypoxemia, respiratory distress syndrome.
Normal ambient air consists mainly of elemental nitrogen (about 78% by volume) and oxygen (about 21% by volume). The nitrogen portion was replaced with the noble gas helium to yield a heliox-helium and oxygen mixture. Because helium has a density of only about 13% of that of nitrogen, heliox can reduce the reynolds number of the gas flow in the gas channel, which facilitates the transition from turbulent to laminar flow. When this transition is followed by the appearance of laminar flow characteristics, work of breathing is reduced because laminar flow has less internal friction than turbulent flow and requires less driving force to move in the airway.
The existing NO administration system is usually matched with the existing breathing machine for use, and has various inconveniences, such as unmatched interfaces, incapability of centralized and unified control, high professional requirements on operators, insufficient safety and the like.
SUMMERY OF THE UTILITY MODEL
In order to facilitate the use of the automatic Nitric Oxide (NO) inhalation system and expand the functions of the automatic nitric oxide inhalation system, the utility model relates to a safe medical instrument which can independently operate and carry out NO inhalation treatment on patients without depending on a breathing machine or other breathing devices.
The therapeutic apparatus of the utility model can be selected by the user with nitrogen (N)2) Or helium (He) as a bottom gas for inhaling NO gas, and oxygen (O) inhaled by the patient can be independently set2) The concentration of (c).
The utility model provides a technical scheme that technical problem adopted is:
an independent nitric oxide administration system for treating respiratory severe diseases comprises an independent box body, wherein an oxygen inlet, a bottom gas inlet, an NO medicament inlet, an air suction pipe orifice, an NO medicament injection orifice, an expiration exhaust orifice, a gas sampling orifice and a sampling gas exhaust orifice are arranged on the box body; the box body is also provided with a display panel and an operation button.
An oxygen supply pipeline, a bottom gas supply pipeline, a NO medicament supply pipeline, a sampling gas pipeline, an expiration one-way valve and a central processing unit are arranged in the box body, wherein an inlet of the oxygen supply pipeline is connected with the oxygen inlet, and an inlet of the bottom gas supply pipeline is connected with the bottom gas inlet; the oxygen gas supply pipeline and the bottom gas supply pipeline are converged and enter a mixed gas tank, and the mixed gas tank is connected with the gas suction pipe orifice through a mixed electromagnetic proportional valve; the NO medicine air supply pipeline is connected between the NO medicine air inlet and the NO medicine injection port; the sampling gas pipeline is connected between the gas sampling port and the sampling gas exhaust port, and the expiration check valve is connected with the expiration exhaust port.
The outer side of the box body is also provided with an inspiration pipeline and an expiration pipeline, the inspiration pipeline is respectively connected with the inspiration pipe orifice and the NO medicine injection port, and the expiration pipeline is respectively connected with the expiration one-way valve and the gas sampling port.
The utility model discloses an independent drug delivery system of nitric oxide still includes the medicine air supply for connect NO medicine air inlet, and the medicine air supply includes A class medicine and B class medicine, and A class medicine is NO + N2The concentration of NO in the medicine gas is 600-2000 ppmv, and the rest is N2Gas; the B type medicine is NO + He medicine gas, wherein the concentration of NO is 400 ppmv-5000 ppmv, and the balance is He gas; the class a drug and the class B drug are stored in a closed container at an absolute pressure of 5 to 12MPa, respectively.
Under the specific condition, the oxygen supply pipeline comprises an oxygen one-way valve, an oxygen pressure sensor, an oxygen electromagnetic switch valve, an oxygen electromagnetic proportional valve and an oxygen flow sensor which are connected in sequence.
Under the specific condition, the bottom air supply pipeline comprises a bottom air one-way valve, a bottom air pressure sensor, a bottom air electromagnetic switch valve, a bottom air electromagnetic proportional valve and a bottom air flow sensor which are connected in sequence.
In a specific case, the NO drug gas supply pipeline comprises an NO one-way valve, an NO pressure sensor, an NO electromagnetic switch valve, an NO electromagnetic proportional valve and an NO flow sensor which are connected in sequence.
In a specific case, the sampling gas pipeline comprises a suction pump, a water filter, a gas concentration sensor assembly and a sampling gas one-way valve which are connected in sequence.
In a specific case, the gas concentration sensor assembly includes O2Concentration sensor, NO concentration sensor, and NO2A concentration sensor.
Preferably, a humidifier is connected between the inhalation tube and the inhalation tube orifice.
The utility model discloses an independent drug delivery system of nitric oxide mainly includes the distribution unit, respiratory unit and 3 parts of unit of dosing. Three paths of gas source interfaces are arranged, namely an oxygen gas source, a medicine gas source and a bottom gas source. Wherein, the bottom gas source can be selectively input with a nitrogen source or a helium source. The gas distribution unit controls the oxygen gas source and the bottom gas source, and gas quantities of the oxygen gas source and the bottom gas source are matched according to the set concentration (20-98%) of the inhaled oxygen. The breathing unit controls the pressure and flow of the mixed gas according to the breathing rhythm and tidal volume of the patient, and the auxiliary breathing effect is achieved. The drug administration unit controls the pressure of a drug gas source, and a trace amount of drug gas, namely NO therapeutic gas, is proportionally injected in a respiratory system loop according to the set concentration of NO gas.
The utility model discloses a drug delivery system can independently and automatic configuration inhale nitric oxide gas concentration, can inhale the lung through patient's breathing process with nitric oxide and helium (or nitrogen gas) mixture. The device has compact structure, strong function, simple and convenient operation and high safety.
Drawings
Fig. 1 is a schematic view of the structure of the independent nitric oxide mixing drug delivery device according to the present invention.
Fig. 2 is a schematic front view of a nitric oxide self-contained delivery system according to the present invention.
Fig. 3 is a schematic back view of a nitric oxide self-contained delivery system according to the present invention.
Fig. 4 is a schematic side view of a nitric oxide self-contained delivery system according to the present invention.
Wherein each symbol in the drawings represents respectively: 100-box, 1-oxygen inlet, 2-oxygen one-way valve, 3-oxygen pressure sensor, 4-oxygen electromagnetic switch valve, 5-oxygen electromagnetic proportional valve, 6-oxygen flow sensor, 7-bottom gas inlet, 8-bottom gas one-way valve, 9-bottom gas pressure sensor, 10-bottom gas electromagnetic switch valve, 11-bottom gas electromagnetic proportional valve, 12-bottom gas flow sensor, 13-NO medicine inlet, 14-NO one-way valve, 15-NO pressure sensor, 16-NO electromagnetic switch valve, 17-NO electromagnetic proportional valve, 18-NO flow sensor, 19-mixed gas tank, 20-mixed electromagnetic proportional valve, 21-sampling gas one-way valve, 22-gas concentration sensor component, 23-water filter, 24-inhalation pump, 25-exhalation exhaust port, 26-sampling gas exhaust port, 27-exhalation one-way valve, 28-humidifier, 29-central processing unit, 30-inhalation tube port, 31-exhalation tube, 32-NO medicine injection port, 33-gas sampling port, 34-lung, 35-inhalation tube, 41-display screen, 42-standby key, 43-mute key, 44-menu key, 45-confirm key, 46-knob, 54-power interface, 55-O2Concentration sensor, 56-NO concentration sensor, 57-NO2A concentration sensor.
Detailed Description
The independent nitric oxide delivery system (or delivery device) of the present invention will be described in detail with reference to the accompanying drawings, and it will be understood by those skilled in the art that the following examples are illustrative of the present invention and are not intended to limit the present invention in any way.
Referring to fig. 1 to 4, the independent administration system of nitric oxide according to the present invention includes an independent box 100, and a panel of the box 100 is provided with an oxygen inlet 1, a bottom air inlet 7, an NO medicine inlet 13, an inhalation pipe port 30, an NO medicine injection port 32, an exhalation exhaust port 25, a gas sampling port 33, a sampling gas exhaust port 26, a power supply port 54, and the like.
The box body 100 is provided with an oxygen supply pipeline, a bottom gas supply pipeline, a NO medicine supply pipeline, a sampling gas pipeline, an expiration one-way valve 27 and a central processing unit 29.
Wherein, the oxygen gas supply pipeline comprises an oxygen one-way valve 2, an oxygen pressure sensor 3, an oxygen electromagnetic switch valve 4, an oxygen electromagnetic proportional valve 5 and an oxygen flow sensor 6 which are connected in sequence. The oxygen one-way valve 2 is connected with the oxygen inlet 1, and the oxygen inlet 1 is used for connecting an oxygen source. The bottom gas supply pipeline comprises a bottom gas one-way valve 8, a bottom gas pressure sensor 9, a bottom gas electromagnetic switch valve 10, a bottom gas electromagnetic proportional valve 11 and a bottom gas flow sensor 12 which are connected in sequence. The bottom gas one-way valve 8 is connected with a bottom gas inlet 7, the bottom gas inlet 7 is used for connecting a bottom gas source, and the bottom gas source is a nitrogen source or a helium source. The oxygen gas supply pipeline and the bottom gas supply pipeline are converged and enter the mixed gas tank 19, and the mixed gas tank 19 is connected with the air suction pipe opening 30 through the mixed electromagnetic proportional valve 20.
The NO drug gas supply pipeline comprises an NO one-way valve 14, an NO pressure sensor 15, an NO electromagnetic switch valve 16, an NO electromagnetic proportional valve 17 and an NO flow sensor 18 which are connected in sequence. The NO check valve 14 is connected to the NO drug inlet port and the NO flow sensor 18 is connected to the NO drug injection port 32.
Wherein, the sampling gas pipeline comprises a suction pump 24, a water filter 23, a gas concentration sensor assembly 22 and a sampling gas one-way valve 21 which are connected in sequence. The getter pump 24 is connected to the gas sampling port 33, and the sample gas check valve 21 is connected to the sample gas exhaust port 26. The gas concentration sensor assembly 22 includes O2Concentration sensor 55, NO concentration sensor 56, and NO2And a concentration sensor 57.
The box 100 is also provided with an inhalation duct 35 and an exhalation duct 31. The inhalation tube 35 is connected to the inhalation tube port 30 and the NO drug injection port 32, respectively. The exhalation line 31 is connected to the exhalation check valve 27 and the gas sampling port 33, respectively. The expiratory check valve 27 is connected to the expiratory vent 25. Inhalation and exhalation lines 35 and 31 are connected to the patient's lungs 34 via a mask or trachea. Preferably, a humidifier 28 is connected between the inspiratory line 35 and the inspiratory tube orifice 30.
Referring to fig. 2, the front surface of the case 100 is further provided with a display screen 41 and various operation buttons, such as a standby key 42, a mute key 43, a menu key 44, a confirm key 45, and a knob 46. The display screen 41 is connected with the central processor 29 and each concentration sensor. The central processor 29 is connected with each electromagnetic switch valve, each electromagnetic proportional valve, each pressure sensor and each flow sensor, and is used for receiving, processing and sending instructions. Conventional methods in the art are well known for such control and display, and will not be described in detail herein.
The working process of the independent administration system of nitric oxide of the present invention is briefly described below.
As shown in figure 1, firstly, 3 air sources needed by the equipment are connected, the type of the connected bottom air, the concentration of NO and the concentration of oxygen are set by medical staff through a control panel, and simultaneously, the equipment is started to check the working condition of the equipment. Connecting the breathing pipeline and the oxygen mask to the patient, and enabling the equipment to enter a working state. The equipment can set the flow proportion of oxygen and bottom gas through the oxygen electromagnetic proportional valve and the bottom gas electromagnetic proportional valve according to the set oxygen concentration, and simultaneously controls the oxygen electromagnetic proportional valve according to the breathing rhythm of the patient so as to assist the breathing of the patient. The drug delivery system controls the NO electromagnetic proportional valve according to the drug delivery concentration and the breathing rhythm set by medical personnel. The concentration ratio of NO drug gas to total mixed gas for the patient to inhale is controlled in the range of 20-80 ppmv. The NO drug gas is injected into the inhalation pipeline through the injection port, and the drug gas sample is collected through the gas sampling port after the patient breathes. NO and NO are detected after passing through a gas concentration sensor2And O2And displaying the concentration on a display screen of the equipment in real time.
The utility model discloses a therapeutic instrument selects on equipment according to the patient's state of an illness to use nitrogen gas or helium as the difference of bottom gas, and the medicine gas that this therapeutic instrument inserts also divides 2, and one kind is A class medicine NO + N2The concentration of NO in the medicine gas is 600-2000 ppmv, and the rest is N2Gas; the other is B-type medicine NO + He medicine gas, wherein the concentration of NO is 400 ppmv-5000 ppmv, and the concentration of NO isThe rest is He gas. If the user selects nitrogen as the bottom gas, the corresponding drug gas is of type a, and if the user selects helium as the bottom gas, the corresponding drug gas is of type B.
Method for detecting NO and NO in sampled gas by electrochemical sensor2And O2And monitoring the concentration, and displaying the monitored concentration value on a liquid crystal display screen. When the concentration of the monitored gas exceeds the safety range, the gas monitoring device can automatically give out sound and light alarm.
Claims (7)
1. An independent nitric oxide administration system for treating respiratory severe diseases is characterized by comprising an independent box body,
the box body is provided with an oxygen inlet, a bottom gas inlet, an NO medicine inlet, an air suction pipe orifice, an NO medicine injection port, an expiration exhaust port, a gas sampling port and a sampling gas exhaust port; the box body is also provided with a display panel and an operation button;
an oxygen supply pipeline, a bottom gas supply pipeline, a NO medicament supply pipeline, a sampling gas pipeline, an expiration one-way valve and a central processing unit are arranged in the box body, wherein an inlet of the oxygen supply pipeline is connected with the oxygen inlet, and an inlet of the bottom gas supply pipeline is connected with the bottom gas inlet; the oxygen gas supply pipeline and the bottom gas supply pipeline are converged and enter a mixed gas tank, and the mixed gas tank is connected with the gas suction pipe orifice through a mixed electromagnetic proportional valve; the NO medicine air supply pipeline is connected between the NO medicine air inlet and the NO medicine injection port; the sampling gas pipeline is connected between the gas sampling port and the sampling gas exhaust port, and the expiration check valve is connected with the expiration exhaust port;
the outer side of the box body is also provided with an inspiration pipeline and an expiration pipeline, the inspiration pipeline is respectively connected with the inspiration pipe orifice and the NO medicine injection port, and the expiration pipeline is respectively connected with the expiration one-way valve and the gas sampling port.
2. The independent nitric oxide delivery system of claim 1, wherein the oxygen supply line comprises an oxygen check valve, an oxygen pressure sensor, an oxygen solenoid switch valve, an oxygen solenoid proportional valve and an oxygen flow sensor which are connected in sequence.
3. The independent nitric oxide delivery system of claim 1, wherein the bottom gas supply pipeline comprises a bottom gas one-way valve, a bottom gas pressure sensor, a bottom gas electromagnetic switch valve, a bottom gas electromagnetic proportional valve and a bottom gas flow sensor which are connected in sequence.
4. The nitric oxide independent delivery system of claim 1, wherein the NO drug gas supply line comprises a NO check valve, a NO pressure sensor, a NO solenoid on/off valve, a NO solenoid proportional valve and a NO flow sensor which are connected in sequence.
5. The nitric oxide self-contained drug delivery system of claim 1, wherein the sampling gas line comprises a suction pump, a water filter, a gas concentration sensor assembly and a sampling gas check valve which are connected in sequence.
6. The nitric oxide self-contained delivery system of claim 5, wherein the gas concentration sensor assembly comprises O2Concentration sensor, NO concentration sensor, and NO2A concentration sensor.
7. The nitric oxide self-contained delivery system of claim 1, wherein a humidifier is connected between the inhalation tube and the inhalation tube port.
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| Application Number | Priority Date | Filing Date | Title |
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| CN202021451861.9U CN212416597U (en) | 2020-07-22 | 2020-07-22 | Nitric oxide independent drug delivery system for treating severe respiratory diseases |
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| CN202021451861.9U CN212416597U (en) | 2020-07-22 | 2020-07-22 | Nitric oxide independent drug delivery system for treating severe respiratory diseases |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113967222A (en) * | 2020-07-22 | 2022-01-25 | 张琪 | Nitric oxide gas medicine composition for treating respiratory severe diseases and administration device |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113967222A (en) * | 2020-07-22 | 2022-01-25 | 张琪 | Nitric oxide gas medicine composition for treating respiratory severe diseases and administration device |
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