CN113967222A - Nitric oxide gas medicine composition for treating respiratory severe diseases and administration device - Google Patents
Nitric oxide gas medicine composition for treating respiratory severe diseases and administration device Download PDFInfo
- Publication number
- CN113967222A CN113967222A CN202010708242.1A CN202010708242A CN113967222A CN 113967222 A CN113967222 A CN 113967222A CN 202010708242 A CN202010708242 A CN 202010708242A CN 113967222 A CN113967222 A CN 113967222A
- Authority
- CN
- China
- Prior art keywords
- gas
- medicine
- concentration
- oxygen
- drug
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/007—Pulmonary tract; Aromatherapy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M15/00—Inhalators
- A61M15/0001—Details of inhalators; Constructional features thereof
- A61M15/002—Details of inhalators; Constructional features thereof with air flow regulating means
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M16/00—Devices for influencing the respiratory system of patients by gas treatment, e.g. mouth-to-mouth respiration; Tracheal tubes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M16/00—Devices for influencing the respiratory system of patients by gas treatment, e.g. mouth-to-mouth respiration; Tracheal tubes
- A61M16/10—Preparation of respiratory gases or vapours
- A61M16/12—Preparation of respiratory gases or vapours by mixing different gases
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M16/00—Devices for influencing the respiratory system of patients by gas treatment, e.g. mouth-to-mouth respiration; Tracheal tubes
- A61M16/20—Valves specially adapted to medical respiratory devices
- A61M16/201—Controlled valves
- A61M16/202—Controlled valves electrically actuated
- A61M16/203—Proportional
- A61M16/205—Proportional used for exhalation control
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2202/00—Special media to be introduced, removed or treated
- A61M2202/02—Gases
- A61M2202/025—Helium
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2202/00—Special media to be introduced, removed or treated
- A61M2202/02—Gases
- A61M2202/0266—Nitrogen (N)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2202/00—Special media to be introduced, removed or treated
- A61M2202/02—Gases
- A61M2202/0266—Nitrogen (N)
- A61M2202/0275—Nitric oxide [NO]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2205/00—General characteristics of the apparatus
- A61M2205/18—General characteristics of the apparatus with alarm
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2210/00—Anatomical parts of the body
- A61M2210/10—Trunk
- A61M2210/1025—Respiratory system
- A61M2210/1039—Lungs
Abstract
A nitric oxide gas medicine composition for treating respiratory serious diseases and its administration device are disclosed, wherein the gas medicine composition includes A-class medicine and B-class medicine, the A-class medicine is NO + N2The concentration of NO in the medicine gas is 600-2000 ppmv, and the rest is N2Gas; the B medicine is NO + He medicine gas, wherein the concentration of NO is 400 ppmv-5000 ppmv,the rest is He gas; the class a drug and the class B drug are stored in a closed container at an absolute pressure of 5 to 12MPa, respectively. The administration device comprises an independent box body, wherein an oxygen supply pipeline, a bottom gas supply pipeline, an NO medicament supply pipeline, a sampling gas pipeline, an expiration one-way valve and a central processing unit are arranged in the box body; the outer side of the box body is also provided with an air suction pipeline and an air exhaust pipeline. The drug delivery device of the invention can quickly select whether nitrogen or helium is used as the bottom gas to access NO gas drug types according to different conditions of patients.
Description
Technical Field
The invention relates to the field of medical medicines and instruments, in particular to a nitric oxide gas medicine composition for treating respiratory severe diseases and a medicine delivery device.
Background
Nitric Oxide (NO) is an important vasodilator discovered in recent years to maintain the vascular bed in a relatively relaxed state. The exogenous inhaled low-concentration NO gas has a highly selective pulmonary vasodilation effect, can effectively treat patients with combined diseases such as primary pulmonary arterial hypertension (PH) and Respiratory Distress Syndrome (RDS), and mainly comprises the following diseases: primary pulmonary hypertension, idiopathic neonatal persistent pulmonary hypertension, heart disease complicated with pulmonary arterial hypertension and/or acute respiratory distress, lung disease complicated with acute respiratory distress, congenital diaphragmatic hernia, congenital heart/lung surgery, chronic obstructive pulmonary disease and pulmonary fibrosis, bronchospasm, monopulmonary ventilation complicated with hypoxemia, respiratory distress syndrome.
However, because NO has high toxicity and can only be introduced into patients at very low concentration (5-20ppmv) in clinical application, proper bottom gas and NO are required to be mixed, and nitrogen (N) is selected according to different requirements of patients2) And helium (He) gas as a bottom gas.
In addition, the existing NO administration system usually needs to be matched with the existing breathing machine for use, and has various inconveniences, such as unmatched interfaces, incapability of centralized and unified control, high professional requirements on operators, insufficient safety and the like.
Disclosure of Invention
In order to promote the safe clinical application of Nitric Oxide (NO) gas medicaments, the invention provides a nitric oxide gas medicament combination for treating severe respiratory diseases and a medicament delivery device.
According to the first aspect of the invention, the nitric oxide gas medicine composition for treating the severe respiratory diseases comprises a class A medicine and a class B medicine, wherein the class A medicine is NO + N2The concentration of NO in the medicine gas is 600-2000 ppmv, and the rest is N2Gas; the B type medicine is NO + He medicine gas, wherein the concentration of NO is 400 ppmv-5000 ppmv, and the balance is He gas; the class a drug and the class B drug are stored in a closed container at an absolute pressure of 5 to 12MPa, respectively.
Within the above concentration and pressure ranges, the gaseous drug can be safely stored and transported; and when the patient is treated, the oxygen-containing gas source can be easily mixed and diluted into NO with the content of less than 80ppmv for the patient to inhale. Under preferred conditions, the concentration of NO in the class A drug is between 1000ppmv and 1200ppmv and the concentration of NO in the class B drug is between 500ppmv and 1500 ppmv. In the concentration range, the medicine is more suitable for being inhaled by a patient when the administration flow rate is between 2 and 5L/min after decompression, and the treatment effect is remarkable in clinical practice of treating the pulmonary hypertension of the human.
For further description of class A drugs, see the applicant's previously filed Chinese patent application (CN 201510643012.0). For further description of class B drugs, see the applicant's previously filed Chinese patent application (CN 201710003620.4).
According to a second aspect of the present invention, there is provided a nitric oxide mixing drug delivery device, comprising an independent box body, wherein the box body is provided with an oxygen inlet, a bottom gas inlet, an NO drug inlet, an inhalation tube orifice, an NO drug injection orifice, an exhalation exhaust orifice, a gas sampling orifice and a sampling gas exhaust orifice; the box body is also provided with a display panel and an operation button.
An oxygen supply pipeline, a bottom gas supply pipeline, a NO medicament supply pipeline, a sampling gas pipeline, an expiration one-way valve and a central processing unit are arranged in the box body, wherein an inlet of the oxygen supply pipeline is connected with the oxygen inlet, and an inlet of the bottom gas supply pipeline is connected with the bottom gas inlet; the oxygen gas supply pipeline and the bottom gas supply pipeline are converged and enter a mixed gas tank, and the mixed gas tank is connected with the gas suction pipe orifice through a mixed electromagnetic proportional valve; the NO medicine air supply pipeline is connected between the NO medicine air inlet and the NO medicine injection port; the sampling gas pipeline is connected between the gas sampling port and the sampling gas exhaust port, and the expiration check valve is connected with the expiration exhaust port.
The outer side of the box body is also provided with an inspiration pipeline and an expiration pipeline, the inspiration pipeline is respectively connected with the inspiration pipe orifice and the NO medicine injection port, and the expiration pipeline is respectively connected with the expiration one-way valve and the gas sampling port.
Under the specific condition, the oxygen supply pipeline comprises an oxygen one-way valve, an oxygen pressure sensor, an oxygen electromagnetic switch valve, an oxygen electromagnetic proportional valve and an oxygen flow sensor which are connected in sequence.
Under the specific condition, the bottom air supply pipeline comprises a bottom air one-way valve, a bottom air pressure sensor, a bottom air electromagnetic switch valve, a bottom air electromagnetic proportional valve and a bottom air flow sensor which are connected in sequence.
In a specific case, the NO drug gas supply pipeline comprises an NO one-way valve, an NO pressure sensor, an NO electromagnetic switch valve, an NO electromagnetic proportional valve and an NO flow sensor which are connected in sequence.
In a specific case, the sampling gas pipeline comprises a suction pump, a water filter, a gas concentration sensor assembly and a sampling gas one-way valve which are connected in sequence.
In a specific case, the gas concentration sensor assembly includes O2Concentration sensor, NO concentration sensor, and NO2A concentration sensor.
Preferably, a humidifier is connected between the inhalation tube and the inhalation tube orifice.
The invention designs a safe medical instrument which can independently operate and carry out NO inhalation treatment on a patient without depending on a respirator or other breathing devices. The device mainly comprises 3 parts of a distribution gas system, a respiratory system and a drug delivery system. The device is provided with three paths of gas source interfaces, namely an oxygen gas source, a medicine gas source and a bottom gas source. Wherein, the bottom gas source can be selectively input with a nitrogen source or a helium source. The gas distribution system controls the oxygen gas source and the bottom gas source, and the gas flow of the oxygen gas source and the bottom gas source is matched according to the set concentration (20-98%) of the inhaled oxygen. The breathing system controls the pressure and flow of the mixed gas according to the breathing rhythm and tidal volume of the patient, and the auxiliary breathing effect is achieved. The medicine feeding system controls the pressure of medicine gas source and injects micro medicine gas, i.e. NO treating gas, into the respiratory system loop in certain proportion based on the set NO gas concentration.
According to a third aspect of the present invention, there is also provided a method for co-administering nitric oxide, comprising the steps of:
(1) the nitric oxide mixed administration device provided by the second aspect of the invention is adopted.
(2) 3 kinds of air supplies that the connected equipment needs and set for the end gas type of inserting, the concentration and the oxygen concentration of NO through control panel by medical personnel, equipment starts simultaneously, checks equipment behavior.
(3) Connecting the breathing pipeline and the oxygen mask to a patient, and enabling the equipment to enter a working state; the device sets the flow proportion of oxygen and bottom gas through the oxygen electromagnetic proportional valve and the bottom gas electromagnetic proportional valve according to the set oxygen concentration, and controls the electromagnetic proportional valve according to the breathing rhythm of the patient so as to assist the patient to breathe.
(4) The drug delivery system controls the NO electromagnetic proportional valve according to the drug delivery concentration and the breathing rhythm set by medical personnel, NO drug gas is injected into an inhalation pipeline through an injection port, and a drug gas sample is collected through a gas sampling port after the patient breathes; NO and NO are detected after passing through a gas concentration sensor2And O2The concentration is displayed on a display screen of the equipment in real time; when the concentration of the monitored gas exceeds the safety range, the gas monitoring device can automatically give out sound and light alarm.
Preferably, the concentration ratio of NO drug gas inhaled by the patient in step (4) to the total mixed gas is controlled to be in the range of 20-80 ppmv.
The nitric oxide gas medicine combination and the administration device provided by the invention can select nitrogen (N) according to the condition of a patient2) Or helium (He) as a base gas for inhaling NO gas, and may be provided for patient inhalation of oxygen (O)2) Can be mixed with helium (or nitrogen) gas and inhaled into the lungs through the breathing process of the patient. The device has compact structure, strong function, simple and convenient operation and high safety.
Drawings
Fig. 1 is a schematic view of the structural principle of the mixed administration device of nitric oxide according to the present invention.
Fig. 2 is a schematic front view of a nitric oxide co-administration device according to the present invention.
Fig. 3 is a schematic rear view of a nitric oxide co-administration device according to the present invention.
Fig. 4 is a schematic side view of a nitric oxide co-administration device according to the present invention.
Wherein each symbol in the drawings represents respectively: 100-box, 1-oxygen inlet, 2-oxygen one-way valve, 3-oxygen pressure sensor, 4-oxygen electromagnetic switch valve, 5-oxygen electromagnetic proportional valve, 6-oxygen flow sensor, 7-bottom gas inlet, 8-bottom gas one-way valve, 9-bottom gas pressure sensor, 10-bottom gas electromagnetic switch valve, 11-bottom gas electromagnetic proportional valve, 12-bottom gas flow sensor, 13-NO medicine inlet, 14-NO one-way valve, 15-NO pressure sensor, 16-NO electromagnetic switch valve, 17-NO electromagnetic proportional valve, 18-NO flow sensor, 19-mixed gas tank, 20-mixed electromagnetic proportional valve, 21-sampling gas one-way valve, 22-gas concentration sensor component, 23-water filter, 24-inhalation pump, 25-exhalation exhaust port, 26-sampling gas exhaust port, 27-exhalation one-way valve, 28-humidifier, 29-central processing unit, 30-inhalation tube port, 31-exhalation tube, 32-NO medicine injection port, 33-gas sampling port, 34-lung, 35-inhalation tube, 41-display screen, 42-standby key, 43-mute key, 44-menu key, 45-confirm key, 46-knob, 54-power interface, 55-O2Concentration sensor, 56-NO concentration sensor, 57-NO2A concentration sensor.
Detailed Description
The following detailed description of the nitric oxide gas drug combination and the mixed drug delivery device for the treatment of severe respiratory diseases in accordance with the present invention will be given with reference to the accompanying drawings, and it will be understood by those skilled in the art that the following examples are given by way of illustration only and are not intended to limit the present invention in any way.
The nitric oxide gas medicine composition comprises A medicine and B medicine, wherein the A medicine is NO + N2A drug gas wherein the concentration of NO is600ppmv to 2000ppmv, the rest being N2Gas; the B medicine is NO + He medicine gas, wherein the concentration of NO is 400 ppmv-5000 ppmv, and the balance is He gas. The class a drug and the class B drug are stored in a closed container at an absolute pressure of 5 to 12MPa, respectively.
Referring to fig. 1 to 4, the mixed administration device of nitric oxide according to the present invention includes a separate housing 100, and an oxygen inlet 1, a bottom gas inlet 7, an NO drug inlet 13, an inhalation nozzle 30, an NO drug injection port 32, an exhalation exhaust port 25, a gas sampling port 33, a sampling gas exhaust port 26, a power supply port 54, etc. are formed on a panel of the housing 100.
The box body 100 is provided with an oxygen supply pipeline, a bottom gas supply pipeline, a NO medicine supply pipeline, a sampling gas pipeline, an expiration one-way valve 27 and a central processing unit 29.
Wherein, the oxygen gas supply pipeline comprises an oxygen one-way valve 2, an oxygen pressure sensor 3, an oxygen electromagnetic switch valve 4, an oxygen electromagnetic proportional valve 5 and an oxygen flow sensor 6 which are connected in sequence. The oxygen one-way valve 2 is connected with the oxygen inlet 1, and the oxygen inlet 1 is used for connecting an oxygen source. The bottom gas supply pipeline comprises a bottom gas one-way valve 8, a bottom gas pressure sensor 9, a bottom gas electromagnetic switch valve 10, a bottom gas electromagnetic proportional valve 11 and a bottom gas flow sensor 12 which are connected in sequence. The bottom gas one-way valve 8 is connected with a bottom gas inlet 7, the bottom gas inlet 7 is used for connecting a bottom gas source, and the bottom gas source is a nitrogen source or a helium source. The oxygen gas supply pipeline and the bottom gas supply pipeline are converged and enter the mixed gas tank 19, and the mixed gas tank 19 is connected with the air suction pipe opening 30 through the mixed electromagnetic proportional valve 20.
The NO drug gas supply pipeline comprises an NO one-way valve 14, an NO pressure sensor 15, an NO electromagnetic switch valve 16, an NO electromagnetic proportional valve 17 and an NO flow sensor 18 which are connected in sequence. The NO check valve 14 is connected to the NO drug inlet port and the NO flow sensor 18 is connected to the NO drug injection port 32.
Wherein, the sampling gas pipeline comprises a suction pump 24, a water filter 23, a gas concentration sensor assembly 22 and a sampling gas one-way valve 21 which are connected in sequence. The getter pump 24 is connected to the gas sampling port 33, and the sample gas check valve 21 is connected to the sample gas exhaust port 26. The gas concentration sensor assembly 22 includes O2Concentration sensingDevice 55, NO concentration sensor 56, and NO2And a concentration sensor 57.
The box 100 is also provided with an inhalation duct 35 and an exhalation duct 31. The inhalation tube 35 is connected to the inhalation tube port 30 and the NO drug injection port 32, respectively. The exhalation line 31 is connected to the exhalation check valve 27 and the gas sampling port 33, respectively. The expiratory check valve 27 is connected to the expiratory vent 25. Inhalation and exhalation lines 35 and 31 are connected to the patient's lungs 34 via a mask or trachea. Preferably, a humidifier 28 is connected between the inspiratory line 35 and the inspiratory tube orifice 30.
Referring to fig. 2, the front surface of the case 100 is further provided with a display screen 41 and various operation buttons, such as a standby key 42, a mute key 43, a menu key 44, a confirm key 45, and a knob 46. The display screen 41 is connected with the central processor 29 and each concentration sensor. The central processor 29 is connected with each electromagnetic switch valve, each electromagnetic proportional valve, each pressure sensor and each flow sensor, and is used for receiving, processing and sending instructions. Conventional methods in the art are well known for such control and display, and will not be described in detail herein.
The operation of the nitric oxide co-administration device according to the present invention will be briefly described.
As shown in figure 1, firstly, 3 air sources needed by the equipment are connected, the type of the connected bottom air, the concentration of NO and the concentration of oxygen are set by medical staff through a control panel, and simultaneously, the equipment is started to check the working condition of the equipment. Connecting the breathing pipeline and the oxygen mask to the patient, and enabling the equipment to enter a working state. The equipment can set the flow proportion of oxygen and bottom gas through the oxygen electromagnetic proportional valve and the bottom gas electromagnetic proportional valve according to the set oxygen concentration, and simultaneously controls the oxygen electromagnetic proportional valve according to the breathing rhythm of the patient so as to assist the breathing of the patient. The drug delivery system controls the NO electromagnetic proportional valve according to the drug delivery concentration and the breathing rhythm set by medical personnel, and NO drug gas is injected into the air suction pipeline through the injection port. The concentration ratio of NO drug gas to total mixed gas for the patient to inhale is controlled in the range of 20-80 ppmv. The patient breathes and then acquires a drug gas sample through the gas sampling port. NO and NO are detected after passing through a gas concentration sensor2And O2Is rich inAnd displaying the data on a display screen of the equipment in real time.
The therapeutic apparatus of the invention can quickly select whether nitrogen or helium is used as bottom gas on the equipment according to the illness state of a patient to access the NO gas drug types. If the user selects nitrogen as the bottom gas, the corresponding drug gas is of type a, and if the user selects helium as the bottom gas, the corresponding drug gas is of type B.
Method for detecting NO and NO in sampled gas by electrochemical sensor2And O2And monitoring the concentration, and displaying the monitored concentration value on a liquid crystal display screen. When the concentration of the monitored gas exceeds the safety range, the gas monitoring device can automatically give out sound and light alarm.
Claims (10)
1. A nitric oxide gas medicine composition for treating respiratory severe diseases is characterized by comprising A medicine and B medicine, wherein the A medicine is NO + N2The concentration of NO in the medicine gas is 600-2000 ppmv, and the rest is N2Gas; the B type medicine is NO + He medicine gas, wherein the concentration of NO is 400 ppmv-5000 ppmv, and the balance is He gas; the class a drug and the class B drug are stored in a closed container at an absolute pressure of 5 to 12MPa, respectively.
2. The nitric oxide gas drug combination for treatment of severe respiratory diseases according to claim 1, wherein the concentration of NO in the class a drug is between 1000ppmv and 1200ppmv and the concentration of NO in the class B drug is between 500ppmv and 1500 ppmv.
3. A nitric oxide mixed drug delivery device is characterized by comprising an independent box body, wherein,
the box body is provided with an oxygen inlet, a bottom gas inlet, an NO medicine inlet, an air suction pipe orifice, an NO medicine injection port, an expiration exhaust port, a gas sampling port and a sampling gas exhaust port; the box body is also provided with a display panel and an operation button;
an oxygen supply pipeline, a bottom gas supply pipeline, a NO medicament supply pipeline, a sampling gas pipeline, an expiration one-way valve and a central processing unit are arranged in the box body, wherein an inlet of the oxygen supply pipeline is connected with the oxygen inlet, and an inlet of the bottom gas supply pipeline is connected with the bottom gas inlet; the oxygen gas supply pipeline and the bottom gas supply pipeline are converged and enter a mixed gas tank, and the mixed gas tank is connected with the gas suction pipe orifice through a mixed electromagnetic proportional valve; the NO medicine air supply pipeline is connected between the NO medicine air inlet and the NO medicine injection port; the sampling gas pipeline is connected between the gas sampling port and the sampling gas exhaust port, and the expiration check valve is connected with the expiration exhaust port;
the outer side of the box body is also provided with an inspiration pipeline and an expiration pipeline, the inspiration pipeline is respectively connected with an inspiration pipe orifice and a NO medicine injection port, and the expiration pipeline is respectively connected with an expiration one-way valve and a gas sampling port;
also comprises A class medicine and B class medicine, wherein the A class medicine is NO + N2The concentration of NO in the medicine gas is 600-2000 ppmv, and the rest is N2Gas; the B type medicine is NO + He medicine gas, wherein the concentration of NO is 400 ppmv-5000 ppmv, and the balance is He gas; the class A drug and the class B drug are stored in a closed container at an absolute pressure of 5 to 12MPa, respectively;
wherein, the NO medicine inlet is used for connecting the A-class medicine or the B-class medicine.
4. The mixed administration device of nitric oxide as claimed in claim 3, wherein the oxygen supply line comprises an oxygen check valve, an oxygen pressure sensor, an oxygen solenoid switch valve, an oxygen solenoid proportional valve and an oxygen flow sensor connected in sequence.
5. The mixed administration device of nitric oxide as claimed in claim 3, wherein the bottom gas supply line comprises a bottom gas check valve, a bottom gas pressure sensor, a bottom gas electromagnetic switch valve, a bottom gas electromagnetic proportional valve and a bottom gas flow sensor connected in sequence.
6. The mixed nitric oxide delivery device of claim 3, wherein the NO drug supply pipeline comprises an NO one-way valve, an NO pressure sensor, an NO electromagnetic switch valve, an NO electromagnetic proportional valve and an NO flow sensor which are connected in sequence.
7. The mixed nitric oxide administration device according to claim 3, wherein the sampling gas pipeline comprises a suction pump, a water filter, a gas concentration sensor assembly and a sampling gas check valve which are connected in sequence.
8. The nitric oxide hybrid delivery device according to claim 7, wherein the gas concentration sensor assembly comprises O2Concentration sensor, NO concentration sensor, and NO2A concentration sensor.
9. The nitric oxide co-delivery device according to claim 1, wherein said base gas is nitrogen or helium.
10. A method of co-administering nitric oxide, comprising the steps of:
(1) use of the nitric oxide co-delivery device of any of claims 3 to 9;
(2) 3 gas sources needed by the equipment are connected, medical personnel set the type of the connected bottom gas, the concentration of NO and the concentration of oxygen through a control panel, and the equipment is started to check the working condition of the equipment;
(3) connecting the breathing pipeline and the oxygen mask to a patient, and enabling the equipment to enter a working state; the equipment sets the flow proportion of oxygen and bottom gas through an oxygen electromagnetic proportional valve and a bottom gas electromagnetic proportional valve according to the set oxygen concentration, and controls the electromagnetic proportional valve according to the breathing rhythm of the patient to assist the patient to breathe;
(4) the drug delivery system controls the NO electromagnetic proportional valve according to the drug delivery concentration and the breathing rhythm set by medical personnel, NO drug gas is injected into an inhalation pipeline through an injection port, and a drug gas sample is collected through a gas sampling port after the patient breathes; NO and NO are detected after passing through a gas concentration sensor2And O2The concentration is displayed on a display screen of the equipment in real time; when the concentration of the monitored gas exceeds the safety range, an audible and visual alarm is automatically sent out.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202010708242.1A CN113967222A (en) | 2020-07-22 | 2020-07-22 | Nitric oxide gas medicine composition for treating respiratory severe diseases and administration device |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202010708242.1A CN113967222A (en) | 2020-07-22 | 2020-07-22 | Nitric oxide gas medicine composition for treating respiratory severe diseases and administration device |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN113967222A true CN113967222A (en) | 2022-01-25 |
Family
ID=79584696
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202010708242.1A Pending CN113967222A (en) | 2020-07-22 | 2020-07-22 | Nitric oxide gas medicine composition for treating respiratory severe diseases and administration device |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN113967222A (en) |
Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102933248A (en) * | 2010-04-29 | 2013-02-13 | 迈柯唯销售服务德国有限公司 | Method and device for supplying at least one medical gas to patient receiving artificial respiration with aid of anesthesia machine |
| CN204017086U (en) * | 2014-06-20 | 2014-12-17 | 昌克勤 | No supply and monitoring device and respiratory system |
| CN104379126A (en) * | 2012-05-24 | 2015-02-25 | 法国液化空气保健国际公司 | No/nitrogen gaseous mixture with a high no content for the treatment of severe hypoxemic respiratory failure |
| CN105168240A (en) * | 2015-09-30 | 2015-12-23 | 徐绍杰 | NO gas-containing drug used for treating human pulmonary artery hypertension and drug delivery system |
| CN106581047A (en) * | 2017-01-04 | 2017-04-26 | 刘平 | Gas medicine for treating respiratory severe diseases through cooperation of nitric oxide gas and helium gas |
| CN212416597U (en) * | 2020-07-22 | 2021-01-29 | 张琪 | Nitric oxide independent drug delivery system for treating severe respiratory diseases |
-
2020
- 2020-07-22 CN CN202010708242.1A patent/CN113967222A/en active Pending
Patent Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102933248A (en) * | 2010-04-29 | 2013-02-13 | 迈柯唯销售服务德国有限公司 | Method and device for supplying at least one medical gas to patient receiving artificial respiration with aid of anesthesia machine |
| CN104379126A (en) * | 2012-05-24 | 2015-02-25 | 法国液化空气保健国际公司 | No/nitrogen gaseous mixture with a high no content for the treatment of severe hypoxemic respiratory failure |
| CN204017086U (en) * | 2014-06-20 | 2014-12-17 | 昌克勤 | No supply and monitoring device and respiratory system |
| CN105168240A (en) * | 2015-09-30 | 2015-12-23 | 徐绍杰 | NO gas-containing drug used for treating human pulmonary artery hypertension and drug delivery system |
| CN106581047A (en) * | 2017-01-04 | 2017-04-26 | 刘平 | Gas medicine for treating respiratory severe diseases through cooperation of nitric oxide gas and helium gas |
| CN212416597U (en) * | 2020-07-22 | 2021-01-29 | 张琪 | Nitric oxide independent drug delivery system for treating severe respiratory diseases |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| US5765558A (en) | Tracheal tube and ventilator system permitting endogenously-produced NO to be combined with respiratory gas | |
| US10543335B2 (en) | Gas flow reversing element | |
| US6196222B1 (en) | Tracheal gas insufflation delivery system for respiration equipment | |
| EP1539283B1 (en) | Pulmonary System with a Plenum-chamber | |
| US6581600B2 (en) | Interface apparatus and combination and method | |
| US9050434B2 (en) | Lung therapy device | |
| KR20180116289A (en) | oxygen mask | |
| CN109731200B (en) | A suction-type anesthesia machine for general anesthesia | |
| CN212416597U (en) | Nitric oxide independent drug delivery system for treating severe respiratory diseases | |
| US7299802B2 (en) | Carbon dioxide delivery apparatus and method for using same | |
| US7533669B2 (en) | Gas delivery system and method | |
| CN113967222A (en) | Nitric oxide gas medicine composition for treating respiratory severe diseases and administration device | |
| Campbell et al. | Nitric oxide and high frequency jet ventilation in a patient with bilateral bronchopleural fistulae and ARDS | |
| JP3860327B2 (en) | Ventilator | |
| JP3860332B2 (en) | Ventilator | |
| US20220062576A1 (en) | Gas inhalation device with constant concentration of gas entering respiratory tract and without respiratory resistance | |
| JP3860330B2 (en) | Ventilator | |
| CN219323754U (en) | Anesthesia machine | |
| JP3860328B2 (en) | Ventilator | |
| JP3860331B2 (en) | Ventilator | |
| US20210338953A1 (en) | System and Method For Ventilating a Person | |
| JP2000051359A (en) | Positive pressure artificial respiration assisting device | |
| JP3860329B2 (en) | Ventilator | |
| JP2000102617A (en) | Positive pressure artificial respiratory auxiliary apparatus | |
| Brudno et al. | Response of pulmonary mechanics to terbutaline in patients with bronchopulmonary dysplasia |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination |