CN212316138U - Sterile system for stem/immune cell production - Google Patents
Sterile system for stem/immune cell production Download PDFInfo
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- CN212316138U CN212316138U CN202020342259.5U CN202020342259U CN212316138U CN 212316138 U CN212316138 U CN 212316138U CN 202020342259 U CN202020342259 U CN 202020342259U CN 212316138 U CN212316138 U CN 212316138U
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Abstract
The utility model relates to an aseptic system for stem cell/immune cell production belongs to the biotechnology field. The utility model provides a current control that is used for the sterile system of stem cell/immune cell production to exist not enough, aseptic environment energy consumption is too high, designs unreasonable problem. The utility model comprises a sterile isolation area for stem cell/immune cell production; the sterile isolation area is provided with a personnel channel for the inlet and outlet of operators and a logistics channel for the inlet and outlet of product materials; the top of the sterile isolation area is provided with an air inlet pipeline mechanism, and the lower part of the sterile isolation area is provided with an air return pipeline; the air inlet pipeline mechanism comprises an air supplementing pipeline, an ozone generator and a VHP generator are arranged on the air supplementing pipeline, a fan is communicated with the air supplementing pipeline, and the air returning pipeline is communicated with the air supplementing pipeline.
Description
Technical Field
The utility model relates to an aseptic system for stem cell/immune cell production belongs to the biotechnology field.
Background
During stem cell/immune cell production, the high requirement to the surrounding environment has been had, both need cleanliness to reach the grade of A level sterile environment, also need real time monitoring its internal environment simultaneously, prevent that environmental parameter such as humiture, oxygen content, pressure differential, planktonic fungus from surpassing the scope of stem cell/immune cell production to can feed back and adjust the inside environment.
At present, stem cell/immune cell production is mostly carried out in an isolator, but the external environment still has more pollution risks, and because the internal environment of the isolator is difficult to realize complete isolation and sealing and the external environment still has circulation, the condition that the internal environment does not reach the standard is caused, and the normal production experiment of the stem cell/immune cell is influenced.
SUMMERY OF THE UTILITY MODEL
The utility model aims to overcome the above-mentioned defect that current sterile system that is used for stem cell/immune cell to produce exists, provided a sterile system that is used for stem cell/immune cell to produce, through adjustment to the atmospheric control and the sterilization control of aseptic isolation region, cooperate aseptic isolator simultaneously for stem cell/immune cell production environment obtains more effective protection and control feedback.
The utility model discloses an adopt following technical scheme to realize:
a sterile system for stem/immune cell production, comprising:
a sterile isolation zone for performing stem cell/immune cell production;
the sterile isolation area is provided with a personnel channel for the inlet and outlet of operators and a logistics channel for the inlet and outlet of product materials;
the top of the sterile isolation area is provided with an air inlet pipeline mechanism, and the lower part of the sterile isolation area is provided with an air return pipeline;
the air inlet pipeline mechanism comprises an air supply pipeline, an ozone generator and a VHP generator are arranged on the air supply pipeline, a fan is communicated on the air supply pipeline, the air return pipeline is communicated on the air supply pipeline, the air supply pipeline is sequentially communicated with a primary filter and a secondary filter, the secondary filter is communicated on a high-efficiency filter through a pipeline, a plurality of groups of high-efficiency filters are arranged above the sterile isolation area in a sealing mode, the air outlet end of each high-efficiency filter is communicated with the sterile isolation area, and an air conditioning system is arranged on the front side of the air supply pipeline and used for adjusting the temperature and humidity of entering air.
Preferably, the aseptic isolation zone in be equipped with aseptic chamber, be equipped with in the aseptic chamber and be used for controlling the aseptic isolator of production stem cell/immune cell terminal environment and be used for controlling aseptic indoor unit's controlling means, be equipped with indoor detection mechanism in the aseptic chamber and be used for detecting humiture and oxygen content, the top of aseptic chamber is equipped with the intermediate layer, high efficiency filter establishes its side reason and intermediate layer sealing connection in the intermediate layer, is equipped with sterile area in the aseptic chamber, the aseptic chamber outside is equipped with the spare area, is equipped with aseptic indoor controlling means in the aseptic chamber for control and demonstration aseptic isolator and the interior environmental parameter of aseptic chamber.
Preferably, the sterile isolator comprises an isolation main bin and a VHP (very high-frequency protocol) sterilization buffer bin on one side, laminar flow covers are arranged at the tops of the isolation main bin and the VHP sterilization buffer bin, the top of each laminar flow cover is sequentially communicated with a filter and an isolation air-conditioning system through a pipeline, the air inlet end of the isolation air-conditioning system is communicated with an isolator air inlet pipe, isolation return air pipes are arranged at the bottoms of the isolation main bin and the VHP sterilization buffer bin, the isolation return air pipes are communicated with the isolator air inlet pipe, and the top of the VHP sterilization buffer bin is communicated with a buffer VHP generator through a pipeline;
and a pipeline at the bottom of the filter is respectively communicated with the laminar flow hoods on the VHP sterilization buffer bin and the isolation main bin after passing through the proportional valve, so that the air pressure entering the inner side is controlled, and the pressure of the isolation main bin is greater than the pressure in the VHP sterilization buffer bin.
Preferably, the isolation main bin and the VHP sterilization buffer bin are communicated through an openable buffer interlocking rear door, and the outer side of the VHP sterilization buffer bin is communicated with the sterile room through an openable buffer interlocking front door.
Preferably, the outer side of the isolation main bin is provided with isolation gloves and a sealing door which are convenient for operating the interior;
and an isolator internal environment monitoring and planktonic bacteria sampler is arranged in the isolation main bin.
Preferably, the personnel passage comprises a personnel wearing and taking-off isolation clothes area and an air shower, the air shower is communicated with the personnel wearing and taking-off isolation clothes area and the sterile room, and air gates are arranged on two communicated sides of the air shower;
the air shower comprises an air shower cabin, a filter is arranged at the top of the air shower cabin and is communicated with an air shower inlet pipeline, side blowing ports are arranged on two sides of the air shower cabin and are communicated with an air outlet end of the filter, an air shower return air channel is arranged at the lower part of the air shower cabin and exhausts air through the air shower return air pipeline;
and the air shower return pipeline is connected to the air shower inlet pipeline.
Preferably, the air shower filter sequentially comprises an air shower primary filter, an air shower intermediate filter and an air shower high-efficiency filter from the air shower air inlet pipeline end.
Preferably, the material flow channel comprises a material temporary storage and transfer area, and the material temporary storage and transfer area is communicated with the sterile room through a transfer window.
Preferably, material sterilization district include steriliser and cleaning machine, the steriliser with the cleaning machine be both sides open the door, a side door with sterilization district intercommunication, another side door of steriliser waits to wash/sterilization room intercommunication with people's stream article, another side door of cleaning machine waits to wash/sterilization room intercommunication with the commodity circulation, people's stream article wait to wash/sterilization room with the commodity circulation is waited to wash/sterilization room and is passed through the air lock intercommunication.
The utility model has the advantages that:
(1) the sterile system for stem cell/immune cell production, fresh air that will supply filters through multilayer filter, dust particle through high efficiency filter control air inlet at last, make its sterile isolation area internal environment reach aseptic standard, carry out VHP sterilization to sterile isolation area through the VHP generator, single batch stem cell/immune cell production clearance carries out ozone disinfection, ensure the environment in the sterile isolation area, terminal environment when controlling stem cell/immune cell production through sterile isolator at last, ensure that the environment is up to standard;
(2) the sterile system for stem cell/immune cell production is provided with the air conditioning system, and the environment temperature and humidity of the sterile isolation area can be adjusted through the air conditioning system, so that the sterile system is suitable for production and operation of products;
(3) a sterile system for stem cell/immune cell production, be provided with personnel's passageway and material passageway, the personnel and the material of control business turn over make it can not destroy the internal environment, set up the sterilization room in the aseptic isolation district simultaneously, can wash and disinfect the article in the aseptic isolation district, ensure the reasonable operation of product.
Drawings
FIG. 1 is a schematic top view of an embodiment of the present invention;
fig. 2 is a top view of a sterile isolation zone according to an embodiment of the present invention;
FIG. 3 is a schematic front view of the structure of the embodiment of the present invention;
FIG. 4 is a schematic structural view of an air shower according to an embodiment of the present invention;
fig. 5 is a schematic structural view of a sterile isolator according to an embodiment of the present invention;
in the figure: 1. an air inlet pipeline mechanism; 1-1, a gas supplementing pipeline; 1-2, a fan; 1-3, a primary filter; 1-4, a medium-efficiency filter; 1-5, high-efficiency filter; 2. an ozone generator; 3. a sterile isolation zone; 3-1, a sterile room; 3-2, a sterile isolator; 3-21, a VHP sterilization buffer bin; 3-22, isolating the main bin; 3-23, sealing door; 3-24, isolation gloves; 3-25, a buffer interlocking front door; 3-26, a buffer interlocking rear door; 3-27, laminar flow hood; 3-28, a filter; 3-29, isolating the air conditioning system; 3-210 parts of an isolator air inlet pipe; 3-211, an isolation return air pipe; 3-212, a buffered VHP generator; 3-213, proportional valve; 3-214, a planktonic bacteria sampler; 3-215, monitoring the environment in the isolator; 3-3, a control device in the sterile room; 3-4, an air conditioner control system; 3-5, spare area; 3-6, a sterilization area; 3-7, an indoor detection mechanism; 3-8, interlayer; 4. a personnel passage; 4-1, putting on and taking off the isolation suit area by personnel; 4-2, an air shower; 4-21, air drenching air inlet pipeline; 4-22, a wind showering primary filter; 4-23, air shower medium effect filter; 4-24, air shower high-efficiency filter; 4-25, side blowing ports; 4-26, air showering air return channel; 4-27, air shower return air pipeline; 5. a material flow channel; 5-1, a transmission window; 5-2, a material temporary storage and transfer area; 6. a material sterilization area; 6-1, a sterilizer; 6-2, cleaning machine; 6-3, a logistics to-be-cleaned/sterilized chamber; 6-4, a room for people to flow articles to be cleaned/sterilized; 7. a VHP generator; 8. a gas return line; 9. an air conditioning system.
Detailed Description
The present invention will be further explained with reference to the accompanying drawings.
As shown in fig. 1-5, a sterile system for stem cell/immune cell production according to the present invention comprises: by using
In a sterile isolation zone 3 for stem cell/immune cell production;
the sterile isolation area 3 is provided with a personnel channel 4 for the entering and exiting of operators, a material flow channel 5 for the entering and exiting of product materials and a material sterilization area 6;
the top of the sterile isolation area 3 is provided with an air inlet pipeline mechanism 1, and the lower part of the sterile isolation area 3 is provided with an air return pipeline 8;
the air inlet pipeline mechanism 1 comprises an air supplement pipeline 1-1, an ozone generator 2 and a VHP generator 7 are arranged on the air supplement pipeline 1-1, the air supplement pipeline 1-1 is communicated with a fan 1-2, the air return pipeline 8 is communicated with the air supplement pipeline 1-1, the air supply pipeline 1-1 is sequentially communicated with a primary filter 1-3 and a middle filter 1-4, the middle-effect filters 1-4 are communicated with the high-effect filters 1-5 through pipelines, a plurality of groups of the high-effect filters 1-5 are hermetically arranged above the sterile isolation area 3, the air outlet end of the high-efficiency filter 1-5 is communicated with the sterile isolation area 3, the front side of the air supply pipeline 1-1 is provided with an air conditioning system 9, used for adjusting the temperature and humidity of the entering air, and the air conditioning system 9 is electrically connected with the air conditioning control system 3-4.
The sterile isolation area 3 is internally provided with a sterile room 3-1, the sterile room 3-1 is internally provided with a sterile isolator 3-2 used for controlling the terminal environment of stem cells/immune cells and a sterile room control device 3-3 used for controlling the equipment in the sterile room, the sterile room 3-4 is internally provided with an indoor detection mechanism 3-7 used for detecting the temperature, the humidity and the oxygen content, the top of the sterile room 3-1 is provided with an interlayer 3-8, the high-efficiency filter 1-5 is arranged in the interlayer 3-8, the side edge of the high-efficiency filter is hermetically connected with the interlayer 3-8, a sterilization area 3-6 is arranged in the sterile room 3-1, a standby area 3-5 is arranged outside the sterile room 3-1, a control device 3-3 in the sterile room is arranged in the sterile room 3-1, for controlling and displaying environmental parameters within aseptic isolator 3-2 and aseptic chamber 3-1.
The sterile isolator 3-2 comprises an isolation main bin 3-22 and a VHP sterilization buffer bin 3-21 on one side, laminar flow hoods 3-27 are arranged at the tops of the isolation main bin 3-22 and the VHP sterilization buffer bin 3-21, the top of each laminar flow hood 3-27 is sequentially communicated with a filter 3-28 and an isolation air-conditioning system 3-29 through a pipeline, the air inlet end of each isolation air-conditioning system 3-29 is communicated with an isolator air inlet pipe 3-210, isolation return air pipes 3-211 are arranged at the bottoms of the isolation main bin 3-22 and the VHP sterilization buffer bin 3-21, the isolation return air pipes 3-211 are communicated with the isolator air inlet pipes 3-210, and the top of the VHP sterilization buffer bin 3-21 is communicated with a buffer VHP generator 3-212 through a pipeline;
the bottom pipelines of the filters 3-28 are respectively communicated with laminar flow hoods 3-27 on the VHP sterilization buffer bins 3-21 and the isolation main bins 3-22 after passing through the proportional valves 3-213, the air pressure entering the inner side is controlled, and the pressure of the isolation main bins 3-22 is larger than the pressure in the VHP sterilization buffer bins 3-21. The filters 3-28 are primary filters and intermediate filters which are connected in series, and enter the high-efficiency filters in the laminar flow hoods 3-27 for further purification after passing through the filters 3-28.
The isolated main bin 3-22 and the VHP sterilization buffer bin 3-21 are communicated through an openable buffer interlocking rear door 3-26, and the outer side of the VHP sterilization buffer bin 3-21 is communicated with the sterile room 3-1 through an openable buffer interlocking front door 3-25.
The front buffer interlocking doors 3-25 and the rear buffer interlocking doors 3-26 are in a double-door interlocking structure, and the two groups of doors cannot be opened simultaneously, so that particles are prevented from entering the VHP sterilization buffer bins 3-21.
The outer side of the isolation main bin 3-22 is provided with isolation gloves 3-24 and a sealing door 3-23 which are convenient for operating the interior;
and an isolator internal environment monitoring device 3-215 and a planktonic bacteria sampler 3-214 are arranged in the isolation main bin 3-22.
The personnel passage 4 comprises a personnel wearing and taking-off isolation clothes area 4-1 and an air shower 4-2, the air shower 4-2 is communicated with the personnel wearing and taking-off isolation clothes area 4-1 and a sterile room 3-1, and air gates are arranged on two communicated sides of the air shower 4-2;
the air shower 4-2 comprises an air shower cabin, a filter is arranged at the top of the air shower cabin and is communicated with an air shower inlet pipeline 4-21, side air blowing ports 4-25 are arranged on two sides of the air shower cabin, the side air blowing ports 4-25 are communicated with an air outlet end of the filter, an air shower return air channel 4-26 is arranged at the lower part of the air shower cabin, and the air shower return air channel 4-26 exhausts air through the air shower return air pipeline 4-27;
the air shower return air pipeline 4-27 is connected to the air shower inlet air pipeline 4-21. The air shower 4-2 is used for carrying out air shower sterilization and disinfection on the entering personnel and controlling particles entering the outer side of the clothes of the personnel.
The air shower filter comprises an air shower primary filter 4-22, an air shower intermediate filter 4-23 and an air shower high-efficiency filter 4-24 in sequence from the end 4-21 of the air shower inlet pipeline.
The material flow channel 5 comprises a material temporary storage and transfer area 5-2, and the material temporary storage and transfer area 5-2 is communicated with the sterile room 3-1 through a transfer window 5-1. The product to be transported enters a transfer area 5-2 and enters an aseptic isolation area 3 through a transfer window 5-1, the transfer window 5-1 is of a double-door interlocking structure, and ultraviolet rays are arranged on the inner side of the transfer window for disinfection and sterilization of the entering articles. Ensuring sterility of the incoming item.
The material sterile area 6 include steriliser 6-1 and cleaning machine 6-2, steriliser 6-1 with 6-2 of cleaning machine be both sides and open the door, a side door with sterile area 3-6 intercommunication, 6-1 another side door of steriliser waits to wash/sterilization room 6-4 intercommunication with the commodity circulation article, 6-2 another side door of cleaning machine waits to wash/sterilization room 6-3 intercommunication with the commodity circulation, the commodity circulation article wait to wash/sterilization room 6-4 with the commodity circulation waits to wash/sterilization room 6-3 through the air lock intercommunication.
S1, adjusting the inner side environment of the sterile isolation area 3;
adjusting gas pressure, and controlling the amount of gas blown into the high-efficiency filter 1-5 by the fan 1-2 to ensure that the sterile isolation area
The pressure at the aseptic isolator 3-2 in the chamber 3 is highest, the pressure in the aseptic chamber 3-1 is lower than the pressure at the aseptic isolator 3-2, the pressure in the aseptic chamber 3-1 is higher than the pressure in the personnel passage 4 and the material flow passage 5, and the pressure in the personnel passage 4 and the material flow passage 5 is higher than the outdoor pressure;
adjusting the temperature and humidity, namely adjusting the temperature and humidity of the gas entering the high-efficiency filters 1-5 through an air conditioner control system 3-4 to achieve adjustment;
s2, sterilizing the sterile isolation area 3;
a VHP generator 7 is communicated with the air supply pipeline 1-1 to enter for sterilization, and comprehensive disinfection and sterilization with a long production period are carried out during VHP sterilization;
an ozone generator 2 is communicated with a gas supplementing pipeline 1-1 to enter for sterilization, and during ozone sterilization, disinfection and sterilization are carried out during single-batch secondary production;
s3, performing feedback regulation on a detection mechanism in the sterile room 3-1;
monitoring indoor temperature and humidity in real time, and monitoring the quality of air entering the sterile isolation area 3 in real time through the detection of a temperature sensor, a humidity sensor, a pressure sensor, an oxygen content sensor and dust particles of an indoor detection mechanism 3-7, so that the air conditioning system 9 is fed back and adjusted to adjust the temperature and humidity, the air inflow is fed back and adjusted, and the gas pressure of the sterile isolation area 3 is increased;
s4, controlling the inner side environment by the sterile isolator 3-2 in the sterile isolation area 3;
the stem cell/immune cell production experiment is carried out in an aseptic isolator 3-2, the temperature and humidity control and the air pressure regulation in the aseptic isolator 3-2 are carried out more strictly, the air pressure entering a VHP sterilization buffer bin 3-21 and an isolation main bin 3-22 is controlled through a proportional valve 3-213, the pressure of the isolation main bin 3-22 is made to be 1-4pa greater than the pressure of the VHP sterilization buffer bin 3-21, the pressure of the VHP sterilization buffer bin 3-21 is made to be 1-4pa greater than the pressure of an aseptic chamber 3-1, and particles in the aseptic chamber 3-1 are prevented from entering the aseptic isolator 3-2;
s5, feedback adjustment of a sterile isolator 3-2 detection mechanism;
the condition of suspended bacteria particles in the sterile isolator 3-2 is monitored in real time through the suspended bacteria sampler 3-214, and the temperature, humidity and oxygen content parameters in the sterile isolator 3-2 are monitored in real time through the environment monitoring in the isolator 3-215, so that the amount of gas entering the high-efficiency filter is fed back and regulated, the gas pressure difference is ensured, and the oxygen content in the sterile isolator 3-2 is regulated through the gas type introduced into the air inlet pipe 3-210 of the isolator.
Of course, the above description is only a preferred embodiment of the present invention, and should not be taken as limiting the scope of the embodiments of the present invention. The present invention is not limited to the above examples, and the technical field of the present invention is equivalent to the changes and improvements made in the actual range of the present invention, which should be attributed to the patent coverage of the present invention.
Claims (9)
1. A sterile system for stem/immune cell production, comprising:
a sterile isolation zone (3) for carrying out stem/immune cell production;
the sterile isolation area (3) is provided with a personnel channel (4) for the entering and exiting of operators, a material flow channel (5) for the entering and exiting of product materials and a material sterilization area (6);
the top of the sterile isolation area (3) is provided with an air inlet pipeline mechanism (1), and the lower part of the sterile isolation area (3) is provided with an air return pipeline (8);
the air inlet pipeline mechanism (1) comprises an air supplementing pipeline (1-1), an ozone generator (2) and a VHP generator (7) are arranged on the air supplementing pipeline (1-1), a fan (1-2) is communicated on the air supplementing pipeline (1-1), an air returning pipeline (8) is communicated on the air supplementing pipeline (1-1), the air supplementing pipeline (1-1) is sequentially communicated with a primary filter (1-3) and a middle-effect filter (1-4), the middle-effect filter (1-4) is communicated on a high-efficiency filter (1-5) through a pipeline, a plurality of groups of high-efficiency filters (1-5) are hermetically arranged above the sterile isolation area (3), the air outlet ends of the high-efficiency filters (1-5) are communicated with the sterile isolation area (3), and an air conditioning system (9) is arranged on the front side of the air supplementing pipeline (1-1), the air conditioning system (9) is electrically connected with the air conditioning control system (3-4) and is used for adjusting the temperature and the humidity of the entering air.
2. The sterile system for stem/immune cell production according to claim 1, characterized in that: the sterile isolation area (3) is internally provided with a sterile room (3-1), the sterile room (3-1) is internally provided with a sterile isolator (3-2) used for controlling the terminal environment of stem cells/immune cells and a sterile room control device (3-3) used for controlling equipment in the sterile room (3-1), the sterile room (3-1) is internally provided with an indoor detection mechanism (3-7) used for detecting temperature, humidity and oxygen content, the top of the sterile room (3-1) is provided with an interlayer (3-8), the high-efficiency filter (1-5) is arranged in the interlayer (3-8) and is hermetically connected with the interlayer (3-8), the sterile room (3-1) is internally provided with a sterile area (3-6), and the outside of the sterile room (3-1) is provided with a spare area (3-5), the sterile room (3-1) is internally provided with a sterile room control device (3-3) which is used for controlling and displaying the environmental parameters in the sterile isolator (3-2) and the sterile room (3-1).
3. The sterile system for stem/immune cell production according to claim 2, characterized in that: the sterile isolator (3-2) comprises an isolation main bin (3-22) and a VHP sterilization buffer bin (3-21) at one side, the tops of the isolation main bin (3-22) and the VHP sterilization buffer bin (3-21) are respectively provided with a laminar flow hood (3-27), the top of the laminar flow hood (3-27) is sequentially communicated with a filter (3-28) and an isolation air-conditioning system (3-29) through a pipeline, the air inlet end of the isolation air-conditioning system (3-29) is communicated with an isolator air inlet pipe (3-210), the bottoms of the isolation main bin (3-22) and the VHP sterilization buffer bin (3-21) are respectively provided with an isolation return air pipe (3-211), the isolation return air pipe (3-211) is communicated with an isolator air inlet pipe (3-210), and the top of the VHP sterilization buffer bin (3-21) is communicated with a buffer VHP generator (3-212) through a pipeline;
and pipelines at the bottoms of the filters (3-28) are respectively communicated with laminar flow hoods (3-27) on the VHP sterilization buffer bins (3-21) and the isolation main bins (3-22) after passing through proportional valves (3-213), so that the air pressure entering the inner side is controlled, and the pressure of the isolation main bins (3-22) is greater than the pressure in the VHP sterilization buffer bins (3-21).
4. The sterile system for stem/immune cell production according to claim 3, characterized in that: the isolated main bin (3-22) and the VHP sterilization buffer bin (3-21) are communicated through an openable buffer interlocking rear door (3-26), and the outer side of the VHP sterilization buffer bin (3-21) is communicated with the sterile room (3-1) through an openable buffer interlocking front door (3-25).
5. The sterile system for stem/immune cell production according to claim 4, characterized in that: the outer side of the isolation main bin (3-22) is provided with isolation gloves (3-24) and a sealing door (3-23) which are convenient for operating the interior;
an isolator internal environment monitoring device (3-215) and a planktonic bacteria sampler (3-214) are arranged in the isolation main bin (3-22).
6. The sterile system for stem/immune cell production according to any one of claims 2-5, characterized in that: the personnel passage (4) comprises a personnel wearing and taking-off isolation clothes area (4-1) and an air shower (4-2), the air shower (4-2) is communicated with the personnel wearing and taking-off isolation clothes area (4-1) and the sterile room (3-1), and air gates are arranged on two communicated sides of the air shower (4-2);
the air shower (4-2) comprises an air shower cabin, a filter is arranged at the top of the air shower cabin and is communicated with an air shower inlet pipeline (4-21), side air blowing ports (4-25) are arranged on two sides of the air shower cabin, the side air blowing ports (4-25) are communicated with an air outlet end of the filter, an air shower return air channel (4-26) is arranged at the lower part of the air shower cabin, and the air shower return air channel (4-26) exhausts air through an air shower return air pipeline (4-27);
the air shower return air pipelines (4-27) are connected to the air shower inlet pipelines (4-21).
7. The sterile system for stem/immune cell production according to claim 6, characterized in that: the air shower filter comprises an air outlet shower primary filter (4-22), an air shower intermediate filter (4-23) and an air shower high-efficiency filter (4-24) in sequence from the end of the air shower inlet pipeline (4-21).
8. The sterile system for stem/immune cell production according to claim 7, characterized in that: the material flow channel (5) comprises a material temporary storage and transfer area (5-2), and the material temporary storage and transfer area (5-2) is communicated with the sterile room (3-1) through a transfer window (5-1).
9. The sterile system for stem/immune cell production according to claim 8, characterized in that: the material sterilization zone (6) include steriliser (6-1) and cleaning machine (6-2), steriliser (6-1) with what cleaning machine (6-2) is both sides and opens the door, a side door with sterilization zone (3-6) intercommunication, another side door of steriliser (6-1) waits to wash/sterilization room (6-4) intercommunication with people stream article, another side door of cleaning machine (6-2) waits to wash/sterilization room (6-3) intercommunication with the commodity circulation, people stream article wait to wash/sterilization room (6-4) and the commodity circulation waits to wash/sterilization room (6-3) and communicates through the air lock.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202020342259.5U CN212316138U (en) | 2020-03-18 | 2020-03-18 | Sterile system for stem/immune cell production |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202020342259.5U CN212316138U (en) | 2020-03-18 | 2020-03-18 | Sterile system for stem/immune cell production |
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| CN212316138U true CN212316138U (en) | 2021-01-08 |
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| CN202020342259.5U Active CN212316138U (en) | 2020-03-18 | 2020-03-18 | Sterile system for stem/immune cell production |
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| GR01 | Patent grant | ||
| GR01 | Patent grant |