CN212261344U

CN212261344U - Optical scanning probe for gynecological examination

Info

Publication number: CN212261344U
Application number: CN202020789204.9U
Authority: CN
Inventors: 马欢; 徐军峰; 王社锋
Original assignee: Zhengzhou Guangchao Medical Technology Co ltd
Current assignee: Zhengzhou Guangchao Medical Technology Co ltd
Priority date: 2020-05-13
Filing date: 2020-05-13
Publication date: 2021-01-01
Anticipated expiration: 2030-05-13

Abstract

The utility model relates to an optical scanning probe for gynecological examination, shake mirror and probe pipe including collimating mirror, scanning, optic fibre is connected to the collimating mirror, the light that the collimating mirror sent shakes the mirror reflection through the scanning and gets into the probe pipe, be equipped with 2n +1 lens in the probe pipe, the afterbody of probe pipe is the bevel connection with slope window sealing connection, the window is plano-convex lens, the utility model discloses a probe has super high resolution, has realized for the first time that the cell level of in the body (in vivo) cervical tissue is imaged, uses to a great extent to reduce the aberration with plano-convex lens as the window, has improved resolution ratio.

Description

Optical scanning probe for gynecological examination

Technical Field

The utility model relates to a technical field of cervical inspection, in particular to an optical scanning probe for gynecological examination.

Background

Cervical cancer is the third largest female malignancy worldwide, the second most common malignancy in women in china. According to the World Health Organization (WHO) estimate, there are more than 47 million new cases of cervical cancer worldwide each year, and china accounts for 28%. By 2025, the incidence of asian cervical cancer will rise by 40% in the absence of appropriate and effective screening methods and preventive measures.

Human Papilloma Virus (HPV) is the main culprit of cervical cancer, and is a very common virus, and as high as 75 percent of women can be infected with HPV at a certain stage of life, and most women can eliminate the virus by means of autoimmunity; however, if the cervical part is infected with HPV continuously for a long time, the cervical part is in a repeated infection state, and cells are mutated to cause canceration. The HPV persistent infection is the main cause of cervical cancer and precancerous lesion thereof, namely Cervical Intraepithelial Neoplasia (CIN), and the heavier the cervical lesion degree is, the higher the high-risk HPV infection rate is.

Fortunately, cervical cancer has a definite etiology and a long, reversible premalignant lesion stage in its development, and is the only malignancy that can reduce morbidity and mortality through medical intervention. This means that cervical cancer is largely a preventable disease.

At present, cervical cancer screening and diagnosis mainly adopts a three-step mode: a first step, cervical cytology examination (TCT) and/or HPV virus detection; secondly, performing colposcopy; third, cervical pathology biopsy.

The existing three-step model has some limitations: firstly, the method is carried out in three steps, so that the method has the advantages of multiple links, long time, large uncertainty and large psychological stress of patients. Secondly, the diagnosis is finally confirmed by a pathological biopsy, but the biopsy is damaged and the available points are limited, and the sampling error may cause missed detection. Third, biopsies may also cause infections. Fourth, some special populations are not suitable for conventional three-step examination, such as pregnant women or patients for post-cervical review.

Some advanced optical image detection means, such as Optical Coherence Tomography (OCT) and confocal imaging, can obtain a high-resolution image of an in-vivo tissue in real time and non-invasively without collecting and specially processing a tissue sample, thereby helping a doctor to quickly and accurately obtain a diagnostic basis and having great clinical application value.

OCT is a high-resolution noninvasive optical imaging technology, and the basic principle of the OCT is a low-coherence light interference technology, and the OCT utilizes low-coherence near-infrared light to irradiate biological tissues and obtains two-dimensional cross-sectional images or three-dimensional reconstruction images with micron-scale resolution of the biological tissues by carrying out interference measurement on scattered light signals. In OCT, image contrast is produced by optical refractive index changes in tissue structures, without the need for exogenous contrast agents, and imaging depths within tissue of about 2-3 mm. OCT is well suited for surface applications such as retinal imaging, and with the development of OCT probe catheter technology in recent years, OCT is increasingly being used in endoscopic fields including cardiovascular, digestive tract, lung, laryngeal and urogenital systems, among others.

Confocal microscopy is an optical imaging technique for front-side (en face) imaging that obtains high resolution and high contrast images by using pinholes to restrict the passage of off-focus light. Confocal microscopy can also reconstruct images of three-dimensional structures by changing the position of the focal plane in the sample. In general, confocal microscopy is superior to OCT in lateral resolution, but inferior to OCT in longitudinal resolution and imaging depth. Because OCT generally uses a single-mode fiber as an optical transmission device, and the single-mode fiber has a very small core diameter and can function as a pinhole, OCT and confocal microscopy have some similar characteristics in imaging. Similar to the OCT technique, the confocal imaging technique can also be applied to the endoscopic field, and the two techniques have certain commonality in the internal snooping head hardware technique. In addition, on the basis of hardware of common confocal scanning, a spectrum technology can be added to realize confocal autofluorescence imaging or fluorescence imaging of exogenous fluorescent dye and the like.

In order to apply these optical detection techniques to cervical disease screening and diagnosis, an important step is to transmit and focus a light beam to a target tissue region, and collect a returned light signal, which is transmitted to a collecting device. In the process, the quality of light beam transmission and focusing directly determines important indexes such as resolution, signal-to-noise ratio and the like of the optical image. Since cervical tissue is inside the human body, the above procedure needs to be performed by means of an endoscopic probe that fulfills certain specific functions, which are different from those of a common endoscope (e.g., gastroscope, bronchoscope, etc.). First, both OCT and confocal imaging focus a beam to a point, and scanning imaging is required, and therefore the probe needs to include a beam scanning function. Second, OCT and confocal imaging require higher resolution than conventional endoscopes, typically on the order of microns. At present, the application of these advanced optical imaging techniques in gynecology is still mainly in the laboratory research stage. In order to apply the advanced optical imaging technology to gynecological clinical application, a probe suitable for high-resolution optical scanning imaging is invented and can meet the requirements of clinical application.

SUMMERY OF THE UTILITY MODEL

In order to solve the technical problem, the utility model provides an optical scanning probe for gynecological examination.

The technical scheme of the utility model is that: the utility model provides an optical scanning probe for gynaecology inspection, includes collimating mirror, scanning galvanometer and probe pipe, the collimating mirror is connected optic fibre, the nearly parallel light that forms after the collimating lens refraction of collimating mirror is passed through to the light beam that diverges that optic fibre jetted out, the nearly parallel light that the collimating mirror sent passes through one section light path and then gets into the probe pipe through scanning galvanometer reflection, the scanning galvanometer is annular scanning's two-dimensional galvanometer, the surface of scanning galvanometer is the level crossing of plating high reflectance coating, be equipped with 2n +1 lens in the probe pipe, the afterbody of probe pipe sets up the window of slope, the end of probe pipe is the bevel connection with window sealing, the window is planoconvex lens, the nearly parallel light that gets into the probe pipe focuses on the surface of window behind the intraductal lens of probe.

Preferably, the lower side of the bevel opening is inclined towards the inner side.

Preferably, the inner side of the window is convex, and the outer side of the window is plane.

Preferably, the outer side surface of the window is not lower than the surface of the bevel opening.

Preferably, the outer side surface of the window is flush with the surface of the bevel opening.

Preferably, the outer side surface of the window extends out of the surface of the bevel opening.

Preferably, 3 lenses are arranged in the probe tube.

Preferably, a reflecting mirror is arranged between the collimating mirror and the scanning galvanometer.

Preferably, the reflector is a plane mirror, a prism or a total reflection prism plated with a high reflection film.

The utility model has the advantages that:

the utility model discloses a probe has ultrahigh resolution, has realized for the first time at the cellular level formation of image of body (in vivo) cervical tissue, uses the great extent with plano-convex lens as the window and has reduced the aberration, has improved resolution ratio.

The utility model provides a scanning galvanometer is annular scanning's two-dimensional galvanometer, and annular scanning has avoided abrupt acceleration, speed reduction, under the same hardware condition (for example logical light bore), has bigger effective imaging area.

Drawings

Fig. 1 is a schematic structural view of the present invention;

FIG. 2 is a graph showing how the present invention uses different optical lenses as windows;

fig. 2 a is a graph showing how the geometric aberration of the present invention is simulated when a plane mirror is used as a window;

fig. 2 b is a graph showing a simulation of the geometric aberration when the plano-convex lens is used as a window according to the present invention;

fig. 3 is an actual view of a USAF1951 resolution board using different optical lenses as windows according to the present invention;

fig. 3 a is an actual view of a USAF1951 resolution plate using a flat mirror as a window according to the present invention;

fig. 3 b is an actual view of a USAF1951 resolution board using a plano-convex lens as a window according to the present invention;

fig. 4 is an image obtained by the probe of the present invention performing an OCT scan on the cervical tissue of the human body in vivo.

In the figure: 1. an optical fiber; 2. a collimating mirror; 3. a mirror; 4. scanning a galvanometer; 5. a probe tube; 6. a lens; 7. a window; 8. sample tissue.

Detailed Description

The specific embodiment of the utility model is shown in figure 1:

the technical scheme of the utility model is that:

an optical scanning probe for gynecological examination, as shown in fig. 1, comprises a collimating mirror 2, a reflecting mirror 3, a scanning galvanometer 4 and a probe tube 5, wherein the collimating mirror 2 is connected with an optical fiber 1, divergent light beams emitted by the optical fiber 1 are refracted by a collimating lens of the collimating mirror 2 to form near parallel light, the near parallel light emitted by the collimating mirror 2 is reflected by the reflecting mirror 3 and the scanning galvanometer 4 to enter the probe tube 5, the surface of the scanning galvanometer 4 is a plane mirror plated with a high reflection film, 3 lenses 6 are arranged in the probe tube 5, an inclined window is arranged at the tail of the probe tube, an inclined opening is arranged at the tail end of the probe tube 5 and is in sealing connection with the window 7, the lower side of the inclined opening is inclined, the window 7 is a plano-convex lens with a convex surface at the inner side and a flat surface at the outer side, the outer side of the window 7 is not lower than the surface of the inclined opening, and the outer side of the window 7 is flush with or extends out of the surface of the inclined, the near-parallel light entering the probe tube passes through a lens 6 in the probe tube and then is focused on the outer surface of the window, and the scanning galvanometer 4 adopts a two-dimensional galvanometer capable of scanning annularly.

The utility model discloses a probe has ultrahigh resolution, like figure 4, has realized for the first time at the cellular level formation of image of body (in vivo) cervical tissue, uses to a great extent to reduce the aberration with plano-convex lens as window 7, has improved resolution ratio.

The utility model discloses the light output port of well optic fibre 1 and scanning equipment host computer is connected, and light signal passes through optic fibre 1 and transmits to scanning probe, after a series of light paths of probe reachd sample tissue 8, the signal of being reflected by sample tissue 8 returns through the original route, transmits back to the equipment host computer by same optic fibre 1, because 1 port core footpath of optic fibre is very little, optic fibre 1 is except playing the light transmission effect, 1 port of optic fibre has also played the required transmission of confocal scanning and has gathered pinhole filtering effect simultaneously.

The utility model provides a collimating mirror 2 contains one or a set of lens 6, and its effect is the collimated light that changes the divergent light of optic fibre 1 output into being close parallel outgoing, and when the light signal returned, collimating mirror 2 still played the focusing effect, focuses on very little area with the light signal that returns to the coupling gets into optic fibre 1, and the cooperation mode of collimating mirror 2 and optic fibre 1 can be fixed knot structure, lets optic fibre 1 port be located the focal plane of collimating mirror 2; the adjustable structure can be adopted, and the distance between the port of the optical fiber 1 and the collimating lens can be adjusted in a manual or electric mode through the matching of the adjustable structure, so that the effect of optimizing the imaging quality or scanning the confocal plane is achieved.

Between the collimating mirror 2 and the galvanometer, between the galvanometer and the probe tube 5, one or more reflectors 3 can be omitted or included; the reflector 3 does not change the divergence or convergence state of the light beam, but only changes the propagation direction of the light beam so as to design the probe structure, for example, to be suitable for hand holding, or in order to meet the incident angle requirement of the optical element, the reflector 3 can be a plane mirror, a prism or a total reflection prism coated with a high reflection film

Scanning mirror 4 is a class angle at certain limit adjustable speculum 3, through electronic system control mirror surface angle to change the reflected beam direction, finally realize the translation scanning of focus point on the probe focal plane, the utility model provides a scanning mirror 4 that shakes is the two-dimensional mirror that shakes of annular scanning, the utility model provides a scanning mirror 4 that shakes applys sine or cosine signal respectively at two scanning directions, forms the annular orbit, and after scanning a week, change annular radius and continue the scanning, form the orbit that is similar to the concentric circles in certain radius interval. Compared with the linear scanning, the main advantages of the annular scanning mode are as follows: the linear scanning lower galvanometer has a larger acceleration and deceleration process at the beginning and the end of each line scanning, so that the part of the image is distorted, and an effective imaging area is reduced; the circular scan avoids sudden acceleration and deceleration and has a larger effective imaging area under the same hardware conditions (e.g., clear aperture).

The utility model provides a 5 both ends of probe pipe are sealed, 5 materials of probe pipe satisfy medical product's biocompatibility requirement, the window 7 of 5 afterbody of probe pipe is the last optical element of beam emergence probe, the sealing on probe top has been guaranteed simultaneously, the slope of window 7 sets up, its normal direction becomes a little angle with the optical axis, this is for reducing 7 interface direct reflection's of window light signal entering light path, the light signal who returns to sample organization 8 interferes to some extent, great aberration can be introduced to the level crossing of slope during the formation of image, reduce the imaging quality, and window 7 that uses plano-convex lens can suppress this kind of aberration to a great extent, obtain higher lateral resolution.

When the probe of the utility model is used, the sample tissue 8 is tightly attached to the surface of the window 7, and a thin transparent isolation sleeve can be sleeved outside the probe to avoid cross infection; the probe covers one scanning area every time, an operator selects different point positions of a patient to scan for multiple times and can cover more areas, a collimating mirror in the probe consists of an optical fiber interface and a collimating lens, the optical fiber interface is connected with an optical fiber of an imaging device, divergent light beams emitted by the optical fiber are refracted by the collimating lens of a collimating mirror 2 to form near parallel light, the near parallel light irradiates the central area of a scanning galvanometer through a section of light path, the surface of the scanning galvanometer is a plane mirror and is plated with a high-reflection film, the near parallel light is reflected by the scanning galvanometer to enter a probe tube, 2n +1 lenses 6 are arranged in the probe tube, the distance between the lenses 6 is adjusted to focus the light beams on the outer surface of a window at the tail part of the probe tube, when the scanning galvanometer is driven by an electric signal to scan, the incident angle of the near parallel light is changed, and the, therefore, the sampling of different positions of a sample is realized, the tail part of the probe tube is provided with an oblique port which is hermetically connected with an oblique window, and the window is a plano-convex lens.

As shown in fig. 2-4, the utility model discloses use plano-convex lens to compare the level crossing as the optical lens of window 7 and can obtain the image of higher resolution ratio, can clearly distinguish the epidermal cell of cervical tissue, and this is also the utility model discloses can be used for the key feature of gynaecology's cervical inspection.

Claims

1. The utility model provides an optical scanning probe for gynaecology's inspection, includes collimating mirror, scanning galvanometer and probe pipe, its characterized in that: the collimating lens is connected with an optical fiber, divergent light beams emitted by the optical fiber are refracted by a collimating lens of the collimating lens to form near parallel light, the near parallel light emitted by the collimating lens passes through a section of light path and then is reflected by a scanning galvanometer to enter a probe tube, the scanning galvanometer is a two-dimensional galvanometer for annular scanning, the surface of the scanning galvanometer is a plane mirror plated with a high reflection film, 2n +1 lenses are arranged in the probe tube, an inclined window is arranged at the tail of the probe tube, the tail end of the probe tube is an inclined opening in sealed connection with the window, the window is a plano-convex lens, and the near parallel light entering the probe tube passes through the lenses in the probe tube and then is focused on the outer surface of the window.

2. An optical scanning probe for gynecological examinations according to claim 1 characterized in that: the lower side of the bevel opening inclines towards the inner side.

3. An optical scanning probe for gynecological examinations according to claim 2 characterized in that: the inner side of the window is a convex surface, and the outer side of the window is a plane.

4. An optical scanning probe for gynecological examinations according to claim 3 characterized in that: the outer side surface of the window is not lower than the surface of the bevel opening.

5. An optical scanning probe for gynecological examinations according to claim 4 characterized in that: the outer side surface of the window is flush with the surface of the bevel connection.

6. An optical scanning probe for gynecological examinations according to claim 4 characterized in that: the outer side surface of the window extends out of the surface of the bevel connection.

7. An optical scanning probe for gynecological examinations according to any of claims 1 to 6 characterized in that: the probe tube is internally provided with 3 lenses.

8. An optical scanning probe for gynecological examinations according to any of claims 1 to 6 characterized in that: and a reflecting mirror is arranged between the collimating mirror and the scanning galvanometer.

9. An optical scanning probe for gynecological examinations according to claim 8 characterized in that: the reflector is a plane mirror, a prism or a total reflection prism plated with a high reflection film.

10. An optical scanning probe for gynecological examinations according to claim 7 characterized in that: and a reflecting mirror is arranged between the collimating mirror and the scanning galvanometer.