CN212255210U - Heating thermostat for liquid chromatography and glycosylated hemoglobin analysis module - Google Patents

Abstract

The utility model discloses a heating constant temperature equipment and glycated haemoglobin analysis module for liquid chromatography, this heating constant temperature equipment include box, heating element, liquid stream pipe and support and press the structure, heating element installs in the box, just heating element prescribes a limit to first installation position and the second installation position that is used for installing the chromatographic column, heating element can heat the chromatographic column, support and press the structure setting to be in the installation intracavity or support and press the structure by at least some formation of box, support and press the structure and be used for supporting the chromatographic column tightly second installation position department. The utility model discloses can prevent that the chromatographic column from taking off heating element for heating element can conduct the heat to the chromatographic column fast, and heat conduction efficiency is high, can shorten detection cycle.

Description

Heating thermostat for liquid chromatography and glycosylated hemoglobin analysis module

Technical Field

The utility model relates to a quality analysis and detection technology field especially relate to a heating constant temperature equipment and glycated haemoglobin analysis module for liquid chromatography.

Background

Before a substance is detected by adopting the liquid chromatography, the liquid flow of a sample and a mobile phase and a chromatographic column need to be heated to a certain temperature, and the temperature is kept constant, so that the accuracy and the repeatability of a detection result are improved.

In the related art, a thermostat is used to heat a sample, a mobile phase, and a chromatography column, and generally, a stainless steel tube and a chromatography column are attached to a heat conductor made of a metal material, and then the heat conductor is heated, so that the temperature of the sample and the mobile phase flowing through the stainless steel tube is increased, and the temperature of the chromatography column is also increased. However, the structure of the incubator has a defect, and particularly, the chromatographic column is often separated from the heat conductor, so that the heat conduction efficiency is low, the time for the temperature to rise to a specified value is prolonged, and the detection period is prolonged.

SUMMERY OF THE UTILITY MODEL

The utility model provides a heating constant temperature equipment and glycated haemoglobin analysis module for liquid chromatography for solve the problem that the heat conduction efficiency is low that current thermostated container exists.

To this end, according to a first aspect, an embodiment provides a heated thermostat for liquid chromatography comprising:

the box body is enclosed to form an installation cavity;

the heating assembly is arranged in the box body and defines a first mounting position and a second mounting position for mounting the chromatographic column, and the heating assembly can heat the chromatographic column;

a flow conduit mounted in the first mounting location, the flow conduit being heated by the heating assembly;

and the abutting structure is arranged in the mounting cavity or is formed by at least one part of the box body, and the abutting structure is used for abutting the chromatographic column at the second mounting position.

In some embodiments of a heated thermostat for liquid chromatography, the heating assembly includes a heat conductor and a heating film attached to a surface of the heat conductor.

In some embodiments of the heated thermostat for liquid chromatography, the heating assembly comprises at least one of the thermal conductors forming the first mounting location and the second mounting location.

In some embodiments of a heated thermostat for liquid chromatography, the heating assembly includes a first thermally conductive body and a second thermally conductive body, the first and second thermally conductive bodies being arranged in an overlapping relationship, the first and second thermally conductive bodies defining the first and second mounting locations therebetween.

In some embodiments of the heated thermostat for liquid chromatography, the heating assembly comprises a first thermal conductor and a second thermal conductor, the first and second thermal conductors being arranged one above the other, the first thermal conductor forming the first mounting location and the second thermal conductor forming the second mounting location.

In some embodiments of the heated thermostat for liquid chromatography, the first mounting location is formed by at least a portion of a surface of the first thermal conductor being recessed.

In some embodiments of the heated thermostat for liquid chromatography, the first mounting location is configured to be circular or circular in cross-section.

In some embodiments of the thermostatic heating device for liquid chromatography, the first installation site has a circular ring-shaped cross section, and the thermostatic heating device further comprises a first conduit pressing structure for pressing the liquid flow conduit against the first installation site.

In some embodiments of the thermostatic heating device for liquid chromatography, the first mounting position has a circular cross-section, and the thermostatic heating device further comprises a second conduit pressing structure for pressing the liquid flow conduit against the first mounting position.

In some embodiments of the heated thermostat for liquid chromatography, the second mounting location is formed by at least a portion of a surface projection of the second thermal conductor.

In some embodiments of the heating thermostat for liquid chromatography, a surface of the second heat conductor is convexly formed with a first stopper column and a second stopper column, and a chromatography column is confined between the first stopper column and the second stopper column.

In some embodiments of the heating thermostat device for liquid chromatography, the height of the first limiting column is smaller than the outer diameter of the chromatographic column, the height of the second limiting column is larger than the outer diameter of the chromatographic column, and the pressing structure includes a pressing part and an elastic part, wherein the elastic part is connected between the pressing part and the second heat conductor and used for generating acting force on the pressing part so that the pressing part presses against the surface of the chromatographic column.

In some embodiments of the heating thermostat for liquid chromatography, the abutting structure includes a spring piece disposed on the first and second limiting columns, the spring piece has a surrounding portion, and the surrounding portion can at least wrap a portion of the chromatography column.

In some embodiments of the heating thermostat device for liquid chromatography, an arc-shaped accommodating cavity is formed between the first limiting column and the second limiting column, a pressing portion is formed above the accommodating cavity of the box body, the pressing portion can press the chromatographic column accommodated in the accommodating cavity, and the pressing portion forms the pressing structure.

In some embodiments of the heating thermostat device for liquid chromatography, the case comprises a first case and a second case which can be fastened to each other, and at least one heat insulating layer is provided on an inner surface of the case.

According to a second aspect, an embodiment provides a glycated hemoglobin analysis module comprising a heated thermostat for liquid chromatography according to the first aspect of the present invention.

Implement the embodiment of the utility model provides a, will have following beneficial effect:

according to the heating thermostat device for liquid chromatography and the glycosylated hemoglobin analysis module in the embodiments, due to the arrangement of the abutting structure, the chromatographic column can be abutted to the second mounting position, so that the chromatographic column can be prevented from separating from the heating assembly, the heating assembly can rapidly conduct heat to the chromatographic column, the heat conduction efficiency is high, and the detection period can be shortened.

Drawings

In order to more clearly illustrate the embodiments of the present invention or the technical solutions in the prior art, the drawings used in the description of the embodiments or the prior art will be briefly described below, it is obvious that the drawings in the following description are only some embodiments of the present invention, and for those skilled in the art, other drawings can be obtained according to these drawings without creative efforts.

Wherein:

fig. 1 is a schematic structural diagram of a heating thermostat device provided according to an embodiment of the present invention;

fig. 2 is a schematic structural view of another angle of a heating thermostat device provided according to an embodiment of the present invention;

fig. 3 is a schematic diagram illustrating an internal structure of a heating thermostat device according to an embodiment of the present invention;

fig. 4 shows a cross-sectional view of a heating thermostat provided according to an embodiment of the present invention;

fig. 5 is a schematic view illustrating an internal structure of another heating thermostat device provided according to an embodiment of the present invention;

fig. 6 shows a cross-sectional view of a heating thermostat provided according to an embodiment of the present invention;

fig. 7 shows another cross-sectional view of a heating thermostat provided in accordance with an embodiment of the present invention;

fig. 8 is a schematic structural diagram of another heating thermostat provided according to an embodiment of the present invention;

fig. 9 is a schematic structural diagram of another heating thermostat device provided according to an embodiment of the present invention;

fig. 10 is a schematic structural diagram illustrating a pressing structure according to an embodiment of the present invention;

fig. 11 is a schematic structural diagram of an elastic sheet according to an embodiment of the present invention;

fig. 12 is a schematic structural diagram of another elastic sheet according to an embodiment of the present invention;

fig. 13 shows a schematic structural diagram of another heating thermostat device provided according to an embodiment of the present invention.

Description of the main element symbols:

100-a box body; 200-a heating assembly; 300-a liquid flow conduit; 400-a pressing structure; 500-a first conduit biasing structure; 600-a second conduit biasing structure; 700-a thermostatic assembly; 101-a mounting cavity; 102-a conduit inlet; 103-outlet port; 110-a first box; 120-a second box; 130-heat insulation layer; 140-a hinge; 150-spring snap; 160-fastening screws; 170-a pressing part; 201-a first installation site; 202-a second mounting location; 203-a recess; 210-a thermal conductor; 220-heating the film; 410-a pressing member; 420-an elastic member; 430-rotation axis; 440-a spring plate; 510-a press plate; 520-a first locking member; 610-briquetting; 620-a second locking member; 710-a temperature sensor; 720-temperature control switch; 211-a first thermally conductive body; 212-a second thermally conductive body; 411-a through hole; 412-step; 431-a body; 432-outer edge; 441-an enclosing part; 442-connecting sheet; 443-a transition piece; 611-step; 2121-a first limit column; 2122-a second limit column; 2123-a receiving cavity; 1000-chromatographic column; 2000-PEEK pipe; a-a wrap-around region; b-containing cavity.

Detailed Description

In order to facilitate understanding of the present invention, the present invention will be described more fully hereinafter with reference to the accompanying drawings. Preferred embodiments of the present invention are shown in the drawings. The invention may, however, be embodied in many different forms and should not be construed as limited to the embodiments set forth herein. Rather, these embodiments are provided so that this disclosure will be thorough and complete.

It will be understood that when an element is referred to as being "secured to" another element, it can be directly on the other element or intervening elements may also be present. When an element is referred to as being "connected" to another element, it can be directly connected to the other element or intervening elements may also be present. The terms "vertical," "horizontal," "left," "right," and the like as used herein are for illustrative purposes only.

Unless defined otherwise, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this invention belongs. The terminology used in the description of the invention herein is for the purpose of describing particular embodiments only and is not intended to be limiting of the invention. As used herein, the term "and/or" includes any and all combinations of one or more of the associated listed items.

The embodiment of the utility model provides a glycosylated hemoglobin analysis module can realize the clinical diagnosis to diabetes.

The glycated hemoglobin analysis module can be applied to apparatuses such as a glycated hemoglobin analyzer, a dual-detection analyzer (which implements two-function detection and analysis, for example, conventional blood detection and glycated hemoglobin detection), and the like, and these apparatuses generally include a rack, various motion mechanisms mounted on the rack, a detection mechanism, and necessary fluid path systems, where the motion mechanisms can be, for example, related mechanisms for performing sample suction, sampling, and sample transportation, and the detection mechanism is generally implemented by an optical detection cell, and the fluid path systems are used for implementing transportation of a sample (a mixed solution obtained by treating a blood sample with a hemolytic agent), an eluent (mobile phase), and recovery of waste liquid generated during detection.

In order to ensure the accuracy of the detection result of the above-mentioned devices, it is necessary to make the sample and the eluent have a certain temperature before entering the optical detection cell, so these devices are generally equipped with a thermostat to raise the temperature of the sample and the eluent to a certain temperature before entering the optical detection cell and maintain the temperature as constant as possible. However, the conventional oven has a drawback of low heat transfer efficiency, so that the inspection period is elongated.

To this end, the embodiment of the present invention provides a glycated hemoglobin analysis module configured with a heating thermostat device for liquid chromatography, which can rapidly heat up samples, eluents, etc. and shorten the detection period.

In an embodiment of the present invention, referring to fig. 1-4, the heating thermostat device for liquid chromatography (hereinafter referred to as "heating thermostat device") includes a box 100, a heating assembly 200, a liquid flow conduit 300, and a pressing structure 400.

Wherein, the box 100 encloses and closes and form installation cavity 101, and heating element 200 installs in box 100, and heating element 200 limits first installation position 201 and the second installation position 202 that is used for installing chromatographic column 1000, and heating element 200 can heat chromatographic column 1000.

The flow conduit 300 is installed at the first installation site 201, and the heating assembly 200 heats the flow conduit 300. the flow conduit 300 is generally made of a material with high thermal conductivity, such as metal, and further, the metal includes but is not limited to stainless steel.

The pressing structure 400 is disposed in the mounting cavity 101 or formed by at least a portion of the box 100, and is used for pressing the chromatography column 1000 against the second mounting position 202, specifically, when the pressing structure 400 is mounted in the mounting cavity 101, the pressing structure 400 may be mounted on the heating assembly 200 or may be mounted on an inner wall of the box 100, which is not limited herein.

In the embodiment of the utility model provides an in, owing to support the setting of pressing structure 400 for chromatographic column 1000 can be supported tightly in second installation position 202 department, can prevent from this that chromatographic column 1000 from taking off heating element 200, makes heating element 200 can conduct the heat to chromatographic column 1000 fast, and heat conduction efficiency is high, can shorten detection cycle.

In an embodiment, referring to fig. 1 to 3 in combination, the box 100 includes a first box 110 and a second box 120 that can be fastened to each other, and at least one layer of heat insulating layer 130 is disposed on an inner surface of the box 100, so that heat in the installation cavity 101 can be prevented from being dissipated to the outside, the temperature in the installation cavity 101 can be kept constant, the temperature of the heated sample, the heated eluent and the chromatographic column 1000 can be kept constant during the detection period, and the accuracy of the detection result can be improved.

Specifically, in some embodiments, the heat insulation layer 130 is made of heat insulation cotton, or the heat insulation layer 130 may be made of heat insulation silicone.

Referring to fig. 1-2, in some specific embodiments, one side of the first casing 110 and one side of the second casing 120 are connected together by a hinge 140, and the other side is provided with a spring buckle 150, so that the first casing 110 and the second casing 120 can be switched between an open state for opening the installation cavity 101 and a closed state for closing the installation cavity 101, thereby facilitating adjustment and maintenance of the heating assembly 200, the liquid flow conduit 300 and the pressing structure 400, and more importantly, facilitating replacement of the chromatography column 1000.

In addition, a pipeline inlet 102 and an outlet 103 are further opened on the box 100, the pipeline inlet 102 is used for guiding the liquid path system into the installation cavity 101 (of course, the liquid path system can also be guided out of the installation cavity 101), as a preferable scheme, the liquid flow conduit 300 positioned in the installation cavity 101 can extend out of the pipeline inlet 102 so as to be convenient for being in butt joint with the pipeline of the liquid path system, and the outlet 103 is used for guiding the circuit of the heating thermostat out of the installation cavity 101, and the circuit can be the circuit of the heating film 220, the temperature sensor 710, the temperature control switch 720 and other components which will be mentioned later.

It should be noted that the embodiment of the present invention is not limited to the specific shape of the box 100, and it may be designed to have the aforementioned structure composed of the first box 110 and the second box 120, and in some possible embodiments, it may also be designed to have a combination of a cover plate and a housing, and the cover plate is covered on the housing to form the installation cavity 101, and the cover plate is movably or detachably installed on the housing to open or close the installation cavity 101. In addition, the first casing 110 and the second casing 120 may be designed to have a rectangular structure, or may be designed to have other structures.

In one embodiment, referring to fig. 3-4, the heating assembly 200 includes a heat conductor 210 and a heating film 220, the heating film 220 is attached to a surface of the heat conductor 210, and the temperature of the heat conductor 210 can be increased by applying power to the heating film 220.

This heat conductor 210 can select for use that thermal conductivity and specific heat are all better common material aluminium to make, not only can make heat conductor 210 heat up fast, can also make heat conductor 210 save certain heat simultaneously.

Referring to fig. 5-7, the heat conductor 210 is designed to be adapted to the installation cavity 101 of the box 100, for example, when the box 100 is a rectangular parallelepiped structure, the heat conductor 210 is also designed to be a rectangular parallelepiped structure, and the dimensions of the two in the length and width directions are the same, so that when the heat conductor 210 is placed in the installation cavity 101, the heat conductor 210 can be attached to the inner surface of the box 100 or the inner surface of the heat insulating layer 130, on one hand, the heat conductor 210 can be stably confined in the installation cavity 101, and on the other hand, the heat dissipation of the heat conductor 210 can be prevented.

In addition, referring to fig. 2 and 4, in order to ensure that the heat conductor 210 has sufficient stability in the installation cavity 101, a fastening screw 160 is further installed at the bottom of the box 100, and the fastening screw 160 penetrates through the box 100 from the outside of the box 100 and extends into the heat conductor 210, so as to fasten the two.

Further, in some specific embodiments, the fastening screw 160 is made of plastic or the like, so that the heat exchange between the installation cavity 101 and the outside through the fastening screw 160 can be prevented, and thus the temperature in the installation cavity 101 can be kept constant.

In addition, a concave portion 203 is recessed on a surface of the heat conductor 210 (for example, the surface is a lower surface of the heat conductor 210 in the orientation shown in fig. 6 and 7) opposite to the first mounting location 201, and the heating film 220 is attached to the surface of the concave portion 203, such that the heating film 220 can be closer to the first mounting location 201, so that heat can be more quickly transferred to the liquid flow conduit 300 at the first mounting location 201.

Of course, in other embodiments, the recess 203 may be disposed opposite to the second mounting position 202, and in addition, two recesses 203 may be formed on the heat conductor 210, and are respectively opposite to the first mounting position 201 and the second mounting position 202.

In a particular embodiment, the heating assembly 200 includes at least one thermal conductor 210, the thermal conductor 210 defining a first mounting location 201 and a second mounting location 202.

It will be understood that the heat conducting body 210 may be provided as one, and the heat conducting body 210 is a unitary structure and is a single component, and the first mounting position 201 and the second mounting position 202 are formed by the heat conducting body 210, and in use, the heat conducting body may be first placed in the mounting cavity 101, and then the liquid flow conduit 300, the chromatographic column 1000 and the pressing structure 400 are mounted at the corresponding positions, so that the assembly process of the entire heating thermostat device can be simplified.

Of course, the thermal conductor 210 may be provided in two or more, which is not limited herein.

For example, in a more specific embodiment, referring to fig. 4, the heating assembly 200 includes a first thermal conductor 211 and a second thermal conductor 212, the first thermal conductor 211 and the second thermal conductor 212 are overlapped and connected together by a locking member such as a screw, and a first mounting position 201 and a second mounting position 202 are formed between the first thermal conductor 211 and the second thermal conductor 212.

It should be noted that, in this case, the first mounting location 201 and the second mounting location 202 may be formed by a gap between the first thermal conductor 211 and the second thermal conductor 212, or by the surfaces of the first thermal conductor 211 and/or the second thermal conductor 212 being matched with each other, and obviously, when the latter is adopted, it is easy to form an all-around wrapping for the liquid flow conduit 300 and the chromatographic column 1000, which is beneficial to improving the heat conduction efficiency.

For another example, in another more specific embodiment, referring to fig. 3-7, the heating assembly 200 includes a first thermal conductor 211 and a second thermal conductor 212, the first thermal conductor 211 and the second thermal conductor 212 are overlapped and connected together by a locking member such as a screw, the first thermal conductor 211 forms the first mounting position 201, and the second thermal conductor 212 forms the second mounting position 202.

At this time, the first mounting portion 201 and the second mounting portion 202 are formed by the first heat conductor 211 and the second heat conductor 212, respectively, and the first heat conductor 211 and the second heat conductor 212 can be processed during actual design, thereby simplifying the processing process.

In a further specific embodiment, the first mounting location 201 is formed by at least a portion of a surface of the first thermal conductor 211 being recessed.

Specifically, the first heat conductor 211 may be machined by numerical control machining, for example, the surface of the first heat conductor 211 may be machined by milling, so that a portion of the surface is recessed to form the first mounting location 201.

The first mounting location 201 may be configured to have a circular or circular cross-section, in other words, when the cross-section of the first mounting location 201 is circular, for example, a milling process is used, and then a milling cutter is fed along the surface of the first heat conductor 211 according to a circular track, and when the cross-section of the first mounting location 201 is circular, the milling cutter is required to mill the entire circular inner area.

Taking the first installation site 201 with a circular cross section as an example, in some cases, referring to fig. 4, the heating and thermostatic device may further include a first conduit pressing structure 500, where the first conduit pressing structure 500 is used for pressing the liquid conduit 300 against the first installation site 201.

Therefore, the liquid flow conduit 300 can be tightly pressed at the first mounting position 201, and the heat conduction efficiency can be improved and the detection period can be shortened in combination with the fact that the chromatographic column 1000 is tightly pressed at the second mounting position 202.

Specifically, the first conduit pressing structure 500 includes a pressing plate 510 and a first locking member 520, the first locking member 520 may be a screw or the like, and the first locking member 520 is used to lock the pressing plate 510 to the first heat conductor 211 and to position the pressing plate 510 directly above the flow conduit 300, so that the flow conduit 300 can be pressed against the first installation site 201.

At this time, it can be understood that, in order to facilitate the installation of the pressure plate 510, a sunken area matching the outer dimension of the pressure plate 510 should be formed above the first installation site 201, so that the surface of the pressure plate 510 can be flush with the surface of the first heat conductor 211 after the pressure plate 510 is installed in place.

Of course, in some cases, referring to fig. 8-9, the sinking area and the first conduit pressing structure 500 may not be provided, and the flow conduit 300 may be directly pressed against the first mounting position 201 through the second heat conductor 212.

Taking the first installation position 201 with a circular cross section as an example, please refer to fig. 6-7, the heating thermostat device may further include a second conduit pressing structure 600, and the second conduit pressing structure 600 is also used for pressing the liquid conduit 300 against the first installation position 201.

Specifically, the second conduit pressing structure 600 includes a pressing block 610 and a second locking member 620, the second locking member 620 may be a screw or the like, and the second locking member 620 is used for locking the pressing block 610 on the first heat conductor 211 and positioning the pressing block 610 right above the flow conduit 300, so that the flow conduit 300 can be pressed against the first installation site 201.

Further, in order to make the flow conduit 300 to be as close to the first heat conductor 211 as possible, the pressing block 610 is designed to be a stepped cylinder shape, and has a cylindrical section with a larger diameter and a cylindrical section with a smaller diameter, and a joint of the two cylindrical sections forms a step 611, so that the cylindrical section with the smaller diameter can surround the first mounting position 201 and the step 611 to form a surrounding area a, so that the flow conduit 300 can be completely surrounded in the surrounding area a, and the heat conduction efficiency can be improved to a certain extent.

In addition, the gap between the liquid flow conduit 300 and the surrounding area A can be filled with heat-conducting silica gel, so that the heat preservation effect can be achieved.

In a further specific embodiment, the second mounting location 202 is formed by at least a portion of a surface projection of the second thermal conductor 212.

Specifically, the second heat conducting body 212 may be formed by removing the excess material by the aforementioned milling process, and in a better way, compared to this way, the structure is added on the surface of the second heat conducting body 212, for example, as shown in fig. 9.

In order to match the external shape of the column 1000, a first limiting column 2121 and a second limiting column 2122 are convexly formed on the surface of the second heat conducting body 212, and the distance between the first limiting column 2121 and the second limiting column 2122 is matched with the external dimension of the column 1000, so that the first limiting column 2121 and the second limiting column 2122 limit the column 1000 in the radial direction in the horizontal direction, as shown in fig. 4, 6, 8 and 9 as an example, the horizontal direction is aligned with the orientation shown in the figure, and the column 1000 is limited in the radial direction in the vertical direction by the pressing structure 400.

In a further specific embodiment, referring to fig. 4, fig. 6 and fig. 10, the height of the first position-limiting post 2121 is smaller than the outer diameter of the chromatography column 1000, the height of the second position-limiting post 2122 is larger than the outer diameter of the chromatography column 1000, the pressing structure 400 includes a pressing element 410 and an elastic element 420, and the elastic element 420 is connected between the pressing element 410 and the second heat conductor 212, and is configured to generate a force on the pressing element 410 so that the pressing element 410 presses against the surface of the chromatography column 1000.

The height of the second limiting column 2122 is set to be greater than the outer diameter of the chromatographic column 1000, so that the chromatographic column 1000 can be prevented from jumping up in the horizontal direction and being separated from the limit of the first limiting column 2121 and the second limiting column 2122, and the height of the first limiting column 2121 is set to be smaller than the outer diameter of the chromatographic column 1000, so as to provide a condition for the pressing member 410 to directly press against the surface of the chromatographic column 1000.

The above-described design of the second mounting location 202 and the compression structure 400 also facilitates replacement of the chromatography column 1000. Specifically, when the chromatographic column 1000 is replaced, the pressing member 410 may be twisted away from the chromatographic column 1000, so that the chromatographic column 1000 is separated from the second mounting position 202 under the action of a PEEK tube (PEEK tube) 2000 (as shown in fig. 3 or fig. 5) having a certain elastic effect, and after the replacement, the pressing member 410 is twisted to be located above the chromatographic column 1000, and then the chromatographic column 1000 is limited.

In some embodiments, referring to fig. 4, 6 and 10 in combination, the pressing structure 400 further includes a rotating shaft 430, the rotating shaft 430 is mounted on the first limiting column 2121, the rotating shaft 430 includes a main body 431 and a rim 432 extending outward from an end of the main body 431, the pressing member 410 has a through hole 411 for the rotating shaft 430 to pass through, the through hole 411 is divided into a large hole section and a small hole section, a step 412 is formed at a joint of the large hole section and the small hole section, the large hole section is matched with the rim 432 in size, the small hole section is matched with the main body 431 in size, so that a closed accommodating cavity B is formed between the rim 432, the main body 431 and the pressing member 410, the elastic member 420 is mounted in the accommodating cavity B, one end of which is connected to the rim 432, and the other end of which is connected to the step 412, the pressing member 410 can rotate around the rotating shaft 430, so as to twist the pressing member 410 away from the chromatographic column 1000, or twisting the pressing member 410 over the column 1000.

In another further embodiment, referring to fig. 8-9 and 11-12, the pressing structure 400 includes a resilient piece 440 disposed on the first and second position-limiting columns 2121 and 2122, the resilient piece 440 has a surrounding portion 441, and the surrounding portion 441 can at least partially surround the chromatography column 1000.

Preferably, the enclosure 441 is designed to be attached to the surface of the column 1000, so as to better confine the column 1000.

The elastic pieces 440 disposed on the first position-limiting post 2121 may be disposed oppositely or separately, and when the position-limiting posts are disposed separately, in order to ensure the position-limiting effect on the chromatographic column 1000, a plurality of elastic pieces 440 should be disposed on the first position-limiting post 2121 and the second position-limiting post 2122, at least two elastic pieces 440 should be disposed on one of the first position-limiting post 2121 and the second position-limiting post 2122, and one elastic piece 440 should be disposed on the other.

As shown in fig. 8, the resilient piece 440 may be directly connected to the first position-limiting post 2121 and the second position-limiting post 2122 by a fastener such as a screw, and at this time, mounting holes are required to be disposed at corresponding positions of the first position-limiting post 2121, the second position-limiting post 2122, and the resilient piece 440.

Of course, as shown in fig. 9, the resilient plate 440 may also be directly connected to the surface of the second thermal conductor 212, and a locking member having a structure substantially the same as that of the first and second retaining columns 2121 and 2122 may be selected to lock the resilient plate 440 to the second thermal conductor 212, and the locking member itself may serve as the first and second retaining columns 2121 and 2122.

As shown in fig. 11, in the manner that the resilient piece 440 is connected to the first and second position-limiting posts 2121 and 2122, the resilient piece 440 at least includes a connecting piece 442 and a transition piece 443 for connecting the connecting piece 442 with the surrounding portion 441, the connecting piece 442 is used for being connected with the first position-limiting post 2121 or the second position-limiting post 2122, and the transition piece 443 plays a role in enhancing the elastic effect of the whole resilient piece 440.

As shown in fig. 12, in the manner that the elastic sheet 440 is directly connected to the surface of the second heat conductor 212, the elastic sheet 440 may also include a connecting sheet 442 and a surrounding portion 441, in which case the connecting sheet 442 is connected to the bottom of the surrounding portion 441.

When actually manufacturing the elastic sheet 440, a sheet made of an elastic material may be selected, and then the sheet is cut into a rectangular parallelepiped structure having a certain width, and then the rectangular parallelepiped structure is converted into the elastic sheet 440 by integrally bending.

Of course, instead of the above-mentioned integral forming method, the elastic piece 440 may also be welded to connect the components of the elastic piece 440 into a whole, and at this time, the components of the elastic piece 440 may even be made of different elastic materials, so that the elastic piece with the elastic effect more suitable for the chromatographic column 1000 may be manufactured.

In some embodiments, to prevent the elastic sheet 440 from scratching the surface of the column 1000, a soft material layer may be further disposed on the surface of the elastic sheet 440, and the soft material layer may have a hardness lower than that of the column 1000.

In a further specific embodiment, referring to fig. 13, an arc-shaped receiving cavity 2123 is formed between the first position-limiting column 2121 and the second position-limiting column 2122, the receiving cavity 2123 forms the second mounting position 202, the box 100 forms a pressing portion 170 above the receiving cavity 2123, the pressing portion 170 can press the chromatographic column 1000 received in the receiving cavity 2123, the pressing portion 170 is specifically formed on the first box 110 of the box 100, or the pressing portion 170 is formed by the heat-insulating layer 130, the pressing portion 170 may be a protrusion, the specific structure of which is not fixed, as long as the pressing portion can press the chromatographic column 1000, and at this time, the pressing portion 170 forms the pressing structure 400.

At this time, it is understood that in the example shown in fig. 13, the first limiting column 2121 and the second limiting column 2122 may be set to be equal in height, and the height (relative to the second heat conductor 212) of the two limiting columns is slightly smaller than the outer diameter of the chromatographic column 1000, and the pressing portion 170 is a rectangular parallelepiped protrusion capable of pressing against the outer circumferential surface of the chromatographic column 1000.

In the example shown in fig. 13, due to the arrangement of the accommodating cavity 2123, a larger area and a closer contact between the chromatography column 1000 and the second thermal conductor 212 can be formed, which is beneficial to improving the heat conduction efficiency.

It should be understood that, various pressing structures 400 may be designed for different first limiting columns 2121 and second limiting columns 2122, and it should be understood that the number and the positions of the pressing structures 400 may be determined according to actual requirements, for example, in the example shown in fig. 5, the pressing structures 400 are arranged in two groups and are respectively disposed at two ends of the chromatography column 1000, and in the example shown in fig. 3, only one group of pressing structures 400 may be arranged and the pressing structure 400 is disposed at a central position of the chromatography column 1000.

On the other hand, as for the parts related to the above, where no material is involved, it is understood that the parts can be made of a material with excellent thermal conductivity to ensure the overall heat conduction efficiency of the heating thermostat device. On the basis, it is better for the first limiting post 2121 and the second limiting post 2122 to extend continuously on the second heat conductor 212, so as to increase the contact surface between the chromatographic column 1000 and the second heat conductor 212, thereby improving the heat conduction efficiency.

In some embodiments, referring to fig. 7, the heating thermostat further includes a thermostat assembly 700 for monitoring and regulating the temperature within the enclosure 100.

Specifically, the thermostatic assembly 700 may include a temperature sensor 710 and a temperature controlled switch 720, the temperature sensor 710 and the temperature controlled switch 720 are disposed inside the heating assembly 200, for example, may be disposed inside the first heat conductor 211, the temperature sensor 710 may monitor the real-time temperature inside the box body 100, and the temperature controlled switch 720 may control the heating efficiency of the heating film 220, so that the heating film 220 always operates in a dynamic balance manner to maintain the temperature inside the box body 100 constant.

The technical features of the embodiments described above may be arbitrarily combined, and for the sake of brevity, all possible combinations of the technical features in the embodiments described above are not described, but should be considered as being within the scope of the present specification as long as there is no contradiction between the combinations of the technical features.

The above-mentioned embodiments only express several embodiments of the present invention, and the description thereof is more specific and detailed, but not construed as limiting the claims. It should be noted that, for those skilled in the art, without departing from the spirit of the present invention, several variations and modifications can be made, which are within the scope of the present invention. Therefore, the protection scope of the present invention should be subject to the appended claims.

Claims (13)

1. A heating thermostat for liquid chromatography, characterized by comprising:

the box body is enclosed to form an installation cavity;

the heating assembly is arranged in the box body and defines a first mounting position and a second mounting position for mounting the chromatographic column, and the heating assembly can heat the chromatographic column;

a flow conduit mounted in the first mounting location, the flow conduit being heated by the heating assembly;

and the abutting structure is arranged in the mounting cavity or is formed by at least one part of the box body, and the abutting structure is used for abutting the chromatographic column at the second mounting position.

2. The heated thermostat for liquid chromatography as claimed in claim 1, wherein said heating member includes a heat conductor and a heating film attached to a surface of said heat conductor.

3. The heated thermostat for liquid chromatography as claimed in claim 2, wherein said heating assembly includes at least one of said thermal conductors, said thermal conductors forming said first mounting location and said second mounting location.

4. The heated thermostat for liquid chromatography as claimed in claim 3, wherein the heating assembly includes a first heat conductor and a second heat conductor, the first heat conductor and the second heat conductor being disposed in an overlapping arrangement, the first heat conductor forming the first mounting location, the second heat conductor forming the second mounting location.

5. The heated thermostat for liquid chromatography as claimed in claim 4, wherein said first mounting position is formed by at least a portion of a surface of said first heat conductor being recessed.

6. The heated thermostat for liquid chromatography as claimed in claim 5, wherein the first mounting position has a circular ring-shaped cross section, and further comprising a first conduit pressing structure for pressing the liquid flow conduit against the first mounting position.

7. The heated thermostat for liquid chromatography as claimed in claim 5, wherein the first mounting position is circular in cross section, and further comprising a second conduit-pressing structure for pressing the liquid flow conduit against the first mounting position.

8. The heated thermostat for liquid chromatography as claimed in claim 4, wherein said second mounting position is formed by at least a part of surface projections of said second heat conductor.

9. The heated thermostat for liquid chromatography as claimed in claim 8, wherein a surface of the second heat conductor is protrusively formed with a first stopper column and a second stopper column, the column being confined between the first stopper column and the second stopper column.

10. The heating thermostat device for liquid chromatography as claimed in claim 9, wherein the height of the first position-limiting column is smaller than the outer diameter of the chromatographic column, the height of the second position-limiting column is larger than the outer diameter of the chromatographic column, and the pressing structure includes a pressing member and an elastic member, the elastic member is connected between the pressing member and the second heat conductor, and is used for generating a force to the pressing member to press the pressing member against the surface of the chromatographic column.

11. The heating thermostat for liquid chromatography as claimed in claim 9, wherein the pressing structure includes a spring piece disposed on the first and second limiting columns, the spring piece having a surrounding portion that can at least partially surround the chromatography column.

12. The heating thermostat device for liquid chromatography as claimed in claim 9, wherein an arc-shaped accommodating cavity is formed between the first limit column and the second limit column, a pressing portion is formed on the box body above the accommodating cavity, the pressing portion can press the chromatographic column accommodated in the accommodating cavity, and the pressing portion forms the pressing structure.

13. Glycated hemoglobin analysis module comprising a heated thermostatic device according to any one of claims 1 to 12.

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