CN220381070U

CN220381070U - Detection device for liquid chromatography system

Info

Publication number: CN220381070U
Application number: CN202321520539.0U
Authority: CN
Inventors: 谢志远; 黄颜; 朱惊涛
Original assignee: Suzhou Saifen Medical Instrument Co ltd
Current assignee: Suzhou Saifen Medical Instrument Co ltd
Priority date: 2023-06-14
Filing date: 2023-06-14
Publication date: 2024-01-23
Anticipated expiration: 2033-06-14

Abstract

The present application provides a detection apparatus for a liquid chromatography system, comprising: the pipe body comprises a flow pipe, and a hole groove is formed in the side part of the flow pipe; the thermosensitive element is placed in the temperature measuring groove and extends from the temperature measuring groove to the liquid circulation area of the circulation pipe; the electric conduction acquisition element comprises a first platinum gold wire and a second platinum gold wire, wherein a first wire is welded at the tail end of the first platinum wire, a second wire is welded at the tail end of the second platinum wire, and the first wire and the second wire are provided with a distance difference along the axial direction of the tube body. According to the technical scheme, the temperature measuring groove for placing the thermosensitive element and the hole groove for fixing the conductance collecting element are formed in the side portion of the tube body, the thermosensitive element is utilized to extend to the region where liquid to be measured in the tube body flows through to measure the temperature, voltage is applied to the first conducting wire and the second conducting wire, current is obtained, the conductance of the liquid between the first conducting wire and the second conducting wire is obtained, and the conductance collecting element and the communicating pipe are attached through welding and other modes, so that the reliability of the conductance is measured and guaranteed under temperature determination.

Description

Detection device for liquid chromatography system

Technical Field

The utility model relates to the technical field of liquid chromatography systems, in particular to a detection device for a liquid chromatography system.

Background

The liquid chromatography (instrument) system is an analysis instrument used in the fields of chemistry, biology and basic medicine, two ends of the instrument are respectively connected with a buffer solution bottle and a waste liquid bottle, and liquid flows into the waste liquid bottle from the buffer solution bottle through the liquid chromatography system, so that parameters (such as conductivity, temperature and the like) of the liquid are obtained for subsequent analysis.

The existing liquid chromatography system adopts a surrounding titanium alloy electrode, and applies voltage to the titanium alloy electrode through a lead wire to obtain feedback current. However, the structural fit of the titanium alloy electrode wrapped flow tube is difficult to ensure, and accurate calculation of the conductance is easy to influence.

Disclosure of Invention

The utility model provides a detection device for a liquid chromatography system, and aims to ensure the detection effect of the detection device of the liquid chromatography system.

In one aspect, an embodiment of the present utility model provides a detection apparatus for a liquid chromatography system, including:

the pipe body comprises a flow pipe, and a temperature measuring groove and at least two hole grooves are formed in the side part of the flow pipe;

the thermosensitive element is placed in the temperature measuring groove and extends from the temperature measuring groove to the liquid circulation area of the circulation pipe;

the electric conduction acquisition element comprises a first platinum gold wire and a second platinum gold wire which are fixed in different hole slots, wherein a first wire is welded at the tail end of the first platinum wire, a second wire is welded at the tail end of the second platinum wire, and the first wire and the second wire have a distance difference along the axial direction of the tube body.

Optionally, further comprising a housing;

the shell comprises a shell body, a first gland and a second gland, wherein the first gland and the second gland are detachably connected with two ends of the shell;

the first gland is equipped with into the liquid hole, and the second gland is equipped with out the liquid hole, goes into liquid hole and goes out the both ends that liquid hole connect the runner pipe respectively.

Optionally, sealing rings are arranged at the joints of the liquid inlet holes, the liquid outlet holes and the runner pipe.

Optionally, one end of the side portion of the shell body is provided with a first thread groove along the axial direction, and the first gland is provided with a first threaded hole matched with the first thread groove.

Optionally, the device further comprises a limiting plate arranged between the shell body and the first gland;

the center of the limiting plate is provided with a first through hole for sleeving the pipe body;

the limiting plate is provided with a second through hole corresponding to the first threaded hole, so that the bolt sequentially passes through the first threaded hole and the second through hole and extends to the first thread groove.

Optionally, the side part of the shell body is perpendicular to the axial direction and is sequentially provided with a third through hole and a fourth through hole;

wherein the first wire and the second wire extend to the outside of the shell through the fourth through hole;

the corresponding lead wires of the thermosensitive element extend to the outside of the shell through the third through hole.

Optionally, the other end of the side part of the shell body is provided with a second thread groove along the axial direction, and the second gland is provided with a second thread hole matched with the second thread groove.

Optionally, the hole groove for fixing the first platinum gold wire and the hole groove for fixing the second platinum gold wire are arranged on the side part of the tube body in a back-to-back way.

Optionally, a positioning ring is circumferentially arranged on the side part of the pipe body; the corresponding end of the shell is provided with a positioning groove.

Optionally, the second gland is provided with a third threaded bore having a size of 10-32UNF.

According to the detection device for the liquid chromatography system, provided by the embodiment of the utility model, the temperature measuring groove for placing the thermosensitive element and the hole groove for fixing the conductivity acquisition element are formed in the side part of the tube body, so that the thermosensitive element is extended to the region where the liquid to be detected flows in the tube body to measure the temperature, the voltage is applied to the first wire and the second wire, the current between the first wire and the second wire is obtained, and the conductivity of the liquid between the first wire and the second wire is obtained.

Drawings

Fig. 1 is a schematic structural diagram of a detection device for a liquid chromatography system according to an embodiment of the present utility model;

fig. 2 is an exploded view of a detection device for a liquid chromatography system according to an embodiment of the present utility model.

In the figure: 1. a tube body; 2. a flow pipe; 3. a temperature measuring groove; 4. a hole groove; 5. a thermosensitive element; 6. a conductance acquisition element; 7. a first platinum gold wire; 8. a second platinum gold wire; 9. a first wire; 10. a second wire; 11. a housing; 12. a housing body; 13. a first gland; 14. a second gland; 15. a liquid inlet hole; 16. a liquid outlet hole; 17. a seal ring; 18. a first thread groove; 19. a first threaded hole; 20. a limiting plate; 21. a first through hole; 22. a second through hole; 23. a third through hole; 24. a fourth through hole; 25. a second thread groove; 26. a second threaded hole; 27. a positioning ring; 28. a positioning groove; 29. and a third threaded hole.

Detailed Description

The utility model is described in further detail below with reference to the drawings and examples. It is to be understood that the specific embodiments described herein are merely illustrative of the utility model and are not limiting thereof. It should be further noted that, for convenience of description, only some, but not all of the structures related to the present utility model are shown in the drawings.

Example 1

In view of the above drawbacks, the present utility model provides a detection apparatus for a liquid chromatography system, as shown in fig. 1 and 2, comprising:

the pipe body 1 comprises a flow pipe 2, and a temperature measuring groove 3 and at least two hole grooves 4 are formed in the side part of the flow pipe 2; the flow pipe 2 is used for enclosing a liquid flowing area to be measured.

A thermal element 5, such as a thermistor, is placed in the temperature measuring tank 3 and extends from the temperature measuring tank 3 to the liquid flowing area of the flow tube 2; the thermosensitive element 5 extends to the flowing area of the liquid to be tested through the temperature measuring groove 3 to test the temperature of the liquid to be tested, but does not influence the normal flow of the liquid to be tested; the corresponding lead wire of the thermosensitive element 5 feeds back temperature data through connection with an upper computer.

The electric conduction acquisition element 6 comprises a first platinum gold wire 7 and a second platinum gold wire 8 which are fixed in different hole slots 4, wherein the first platinum gold wire 7 is welded with a first lead 9, the tail end of the second platinum gold wire 8 is welded with a second lead 10, and the first lead 9 and the second lead 10 have a distance difference along the axial direction of the tube body 1. The upper computer applies voltage through the first wire 9 and the second wire 10, and obtains corresponding current values. Wherein the first platinum gold wire 7 and the second platinum gold wire 8 are preferably welded inside the hole groove 4, thereby forming an integrated structure with the tube body 1 and avoiding falling off in the use process.

Here, the material used for the conductance collecting element 6 includes, but is not limited to, platinum, and the shape may also include a sheet shape or the like. The platinum gold wire material and shape are adopted, on one hand, because the platinum gold has stable physical and chemical properties, the platinum gold wire material and shape can not be corroded when being contacted with acidic and alkaline liquid in a liquid chromatography system, and has excellent electrical properties, so that the stability and accuracy of an experiment result can be ensured; on the other hand, the linear structure is adopted to ensure that the conductivity acquisition element 6 and the pipe body 1 are better in fit.

In a preferred embodiment, the hole groove 4 for fixing the first platinum gold wire 7 and the hole groove 4 for fixing the second platinum gold wire 8 are arranged on the side of the tube body 1 facing away from each other.

And, the detection device further includes a housing 11;

the shell 11 comprises a shell body 12, a first gland 13 and a second gland 14 which are detachably connected with two ends of the shell 11;

the first gland 13 is provided with a liquid inlet hole 15, the second gland 14 is provided with a liquid outlet hole 16, and the liquid inlet hole 15 and the liquid outlet hole 16 are respectively connected with two ends of the runner pipe 2. The joint of the liquid inlet hole 15, the liquid outlet hole 16 and the runner pipe 2 is provided with a sealing ring 17. The function of this sealing ring 17 is to prevent the liquid to be measured from overflowing.

The effect of the shell 11 can reduce the interference of the use environment such as external temperature. A positioning ring 27 is circumferentially arranged on the side part of the pipe body 1; the corresponding end of the housing 11 is provided with a positioning groove 28. During the sleeving process, one side of the pipe body 1 with the positioning ring 27 stretches into the shell 11, and the positioning ring 27 is connected with the positioning groove 28 in a matching way, so that the relative position of the shell 11 and the pipe body 1 is confirmed.

The shell 11, the first gland 13, the second gland 14 and the pipe body 1 are made of polyether-ether-ketone (peek) materials, so that the risk of corrosion can be reduced while the mechanical property is ensured, and the peek materials do not adsorb chemical and biological components and cannot be corroded by the liquid to be detected, so that the detection accuracy and the use stability can be considered.

The side part of the shell body 12 is provided with a third through hole 23 and a fourth through hole 24 in sequence perpendicular to the axial direction, wherein the first lead 9 and the second lead 10 extend to the outside of the shell 11 through the fourth through hole 24;

the corresponding wires of the thermosensitive element 5 extend to the outside of the housing 11 through the third through hole 23. And the third through hole 23 and the fourth through hole 24 are filled with epoxy resin glue, so that the biological adsorptivity is avoided, and the detection accuracy is ensured.

Example two

On the basis of the above technical solution, this embodiment further proposes that one end of the side portion of the housing body 12 is provided with a first thread groove 18 along the axial direction, and the first gland 13 is provided with a first threaded hole 19 matched with the first thread groove 18.

The device also comprises a limiting plate 20 arranged between the shell body 12 and the first gland 13;

the center of the limiting plate 20 is provided with a first through hole 21 for sleeving the pipe body 1;

the limiting plate 20 is provided with a second through hole 22 corresponding to the first threaded hole 19, so that the bolt and/or the screw sequentially passes through the first threaded hole 19, the second through hole 22 and extends to the first threaded groove 18. The limiting plate 20 serves to ensure that the body 1 is positioned at the center of the case body 12, preventing distortion of conductivity due to tilting.

The other end of the side of the housing body 12 is provided with a second screw groove 25 along the axial direction, and the second gland 14 is provided with a second screw hole 26 matched with the second screw groove 25. And the first thread groove 18 and the second thread groove 25, and the first threaded hole 19 and the second threaded hole 26 are preferably the same size (e.g., M2.5) to reduce the complexity of the detection device, and the corresponding screw is M2.5×14. In an alternative embodiment, the first threaded hole 19 and the second threaded hole 26 may be in a through hole structure.

The second gland 14 is provided with a third threaded bore 29, the third threaded bore 29 being of a size of 10-32UNF. The second gland 14 is connected to an external flow guiding element of the liquid to be measured by means of a third threaded hole 29.

The solution provided by the embodiment of the present utility model, which adopts the same technical means as the detection device for a liquid chromatography system provided by the foregoing embodiment, achieves the same technical effects, and is not described herein again.

In the present utility model, some azimuth terms, such as "upper", "lower", "left", "right", "inner" and "outer", are defined, and unless otherwise stated, these terms are used for convenience of understanding, and thus do not limit the scope of the present utility model.

In the present utility model, unless expressly stated or limited otherwise, a first feature "above" or "below" a second feature may include both the first and second features being in direct contact, as well as the first and second features not being in direct contact but being in contact with each other through additional features therebetween. Moreover, a first feature being "above," "over" and "on" a second feature includes the first feature being directly above and obliquely above the second feature, or simply indicating that the first feature is higher in level than the second feature. The first feature being "under", "below" and "beneath" the second feature includes the first feature being directly under and obliquely below the second feature, or simply means that the first feature is less level than the second feature.

In the description of the present utility model, unless explicitly stated and limited otherwise, the terms "connected," "connected," and "fixed" are to be construed broadly, and may be, for example, fixedly connected, detachably connected, or integrally formed; can be mechanically or electrically connected; can be directly connected or indirectly connected through an intermediate medium, and can be communicated with the inside of two elements or the interaction relationship of the two elements. The specific meaning of the above terms in the present utility model will be understood in specific cases by those of ordinary skill in the art.

Claims

1. A detection apparatus for a liquid chromatography system, comprising:

the pipe body (1) comprises a flow pipe (2), wherein a temperature measuring groove (3) and at least two hole grooves (4) are formed in the side part of the flow pipe (2);

a thermosensitive element (5) which is arranged in the temperature measuring groove (3) and extends from the temperature measuring groove (3) to the liquid circulation area of the circulation pipe (2);

the electric conduction acquisition element (6) comprises a first platinum gold wire (7) and a second platinum gold wire (8) which are fixed inside the hole groove (4), wherein a first wire (9) is welded at the tail end of the first platinum gold wire (7), a second wire (10) is welded at the tail end of the second platinum gold wire (8), and the first wire (9) and the second wire (10) are axially provided with a distance difference along the tube body (1).

2. The detection device for a liquid chromatography system according to claim 1, further comprising a housing (11);

the shell (11) comprises a shell body (12), a first gland (13) and a second gland (14) which are detachably connected with two ends of the shell (11);

the first gland (13) is provided with a liquid inlet hole (15), the second gland (14) is provided with a liquid outlet hole (16), and the liquid inlet hole (15) and the liquid outlet hole (16) are respectively connected with two ends of the runner pipe (2).

3. The detection device for a liquid chromatography system according to claim 2, wherein a sealing ring (17) is arranged at the connection of the liquid inlet (15), the liquid outlet (16) and the flow tube (2).

4. The detection device for a liquid chromatography system according to claim 2, wherein a first screw groove (18) is provided at one end of the side portion of the housing body (12) in the axial direction, and the first gland (13) is provided with a first screw hole (19) that matches the first screw groove (18).

5. The detection device for a liquid chromatography system according to claim 4, further comprising a limiting plate (20) disposed between the housing body (12) and the first gland (13);

a first through hole (21) for sleeving the pipe body (1) is formed in the center of the limiting plate (20);

the limiting plate (20) is provided with a second through hole (22) corresponding to the first threaded hole (19), so that the bolt sequentially passes through the first threaded hole (19) and the second through hole (22) and extends to the first threaded groove (18).

6. The detection device for a liquid chromatography system according to claim 2, wherein a third through hole (23) and a fourth through hole (24) are sequentially opened at the side of the housing body (12) perpendicular to the axial direction;

wherein the first wire (9) and the second wire (10) extend to the outside of the shell (11) through the fourth through hole (24);

corresponding wires of the thermosensitive element (5) extend to the outside of the housing (11) through the third through hole (23).

7. The detection device for a liquid chromatography system according to claim 2, wherein a second screw groove (25) is axially provided at the other end of the side portion of the housing body (12), and the second gland (14) is provided with a second screw hole (26) that is matched with the second screw groove (25).

8. The detection device for a liquid chromatography system according to claim 1, wherein the hole groove (4) for fixing the first platinum gold wire (7) and the hole groove (4) for fixing the second platinum gold wire (8) are disposed on a side portion of the tube body (1) facing away from each other.

9. The detection device for a liquid chromatography system according to claim 2, wherein a positioning ring (27) is circumferentially arranged at the side of the tube body (1);

and a positioning groove (28) is arranged at the corresponding end of the shell (11).

10. The detection device for a liquid chromatography system according to claim 2, wherein the second gland (14) is provided with a third threaded hole (29), the third threaded hole (29) having a size of 10-32UNF.