CN212236056U - N-acetyl-D-glucosamine recrystallization device - Google Patents
N-acetyl-D-glucosamine recrystallization device Download PDFInfo
- Publication number
- CN212236056U CN212236056U CN202020734203.4U CN202020734203U CN212236056U CN 212236056 U CN212236056 U CN 212236056U CN 202020734203 U CN202020734203 U CN 202020734203U CN 212236056 U CN212236056 U CN 212236056U
- Authority
- CN
- China
- Prior art keywords
- cavity
- recrystallization
- glucosamine
- acetyl
- plate
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Images
Abstract
The utility model discloses an N-acetyl-D-glucosamine recrystallization device, which is provided with a crystallization tank body, wherein an inner cavity of the crystallization tank body is provided with a stirring and dissolving cavity, a filtering cavity and a recrystallization cavity from top to bottom; the top of the stirring and dissolving cavity is provided with an electric heating rod and a feed inlet which penetrate through the outer wall of the crystallization tank body; an active carbon filter plate is arranged at the bottom of the filter cavity, active carbon is filled in the active carbon filter plate, a condensing pipe is wound on the outer wall of the recrystallization cavity, and circulating glacial ethanol is introduced into the condensing pipe; after the N-acetyl-D-glucosamine crude product is heated and dissolved by the solvent, the activated carbon filter plate further decolors and removes impurities from the crude product, so that the purity of the N-acetyl-D-glucosamine in the crude product solution is improved, and the yield and the purity of the N-acetyl-D-glucosamine in the recrystallization process are improved.
Description
Technical Field
The utility model relates to a recrystallization equipment field, concretely relates to N-acetyl-D-glucosamine recrystallization device.
Background
N-acetyl-D-glucosamine is a novel biochemical drug, is a composition unit of various polysaccharides in organisms, particularly has the highest exoskeleton content in crustaceans, and is a medicament for clinically treating rheumatic and rheumatoid arthritis. The conventional refining process of the N-acetyl-D-glucosamine comprises the steps of firstly adding a decoloring agent, stirring and decoloring, filtering by a filter after decoloring, heating and concentrating in vacuum, adding an organic solvent after cooling the concentrated solution, recrystallizing, carrying out high-speed centrifugation on crystals, soaking and washing, and drying to obtain a refined product.
Currently, there are few reports on an N-acetyl-D-glucosamine recrystallization device, and the prior art (CN205699544U) discloses a sealed recrystallization purification device, which includes a tank body, a tank cover, an inner tank body and a rotating shaft; the inner tank body is arranged in the outer tank body, and the rotating shaft penetrates through the outer tank body and is fixedly connected with the outer tank body and the side wall of the inner tank body; the temperature control unit and the inner filter screen are arranged in the inner tank body, a feeding port is arranged on the side wall of the inner tank body and penetrates through the side wall of the outer tank body, and the inner tank body is communicated with the inside of the outer tank body through a discharging port arranged at the top; the internal outer filter screen that is equipped with of outer jar, the bottom of the outer jar of body is equipped with the leakage fluid dram, and the outer jar of body can be dismantled with the cover and be connected. This closed type recrystallization purification device makes whole recrystallization process all carry out under airtight environment, does not receive external pollution, helps improving crystallization purity. However, the following technical problems exist: 1) the N-acetyl-D-glucosamine can not be further decolored and purified, and the yield and purity of the N-acetyl-D-glucosamine can not be further improved through heating dissolution and a filtering structure; 2) the crystal is easily adhered to the inner wall of the recrystallization cavity and is not easy to remove, the recrystallization yield is reduced, and the cleaning cost of the recrystallization cavity is increased.
SUMMERY OF THE UTILITY MODEL
In order to solve the above technical problems, an object of the present invention is to provide an N-acetyl-D-glucosamine recrystallization device.
The purpose of the utility model can be realized by the following technical scheme:
an N-acetyl-D-glucosamine recrystallization device comprises a crystallization tank body, wherein an inner cavity of the crystallization tank body is provided with a stirring and dissolving cavity, a filtering cavity and a recrystallization cavity from top to bottom; the top of the stirring and dissolving cavity is provided with an electric heating rod and a feed inlet which penetrate through the outer wall of the crystallization tank body; a first motor is arranged at the center of the top of the crystallizing tank body, a motor shaft of the first motor is connected with a stirring shaft extending into the stirring and dissolving cavity, a stirring blade is rotatably connected on the stirring shaft, and the bottom of the stirring and dissolving cavity is connected with the top of the filtering cavity through a first stop valve;
an active carbon filter plate is arranged at the bottom of the filter cavity, active carbon is filled in the active carbon filter plate, a condensing pipe is wound on the outer wall of the recrystallization cavity, and circulating glacial ethanol is introduced into the condensing pipe;
a top stretching cylinder is arranged at the bottom of the crystallization tank body, and a telescopic shaft of the top stretching cylinder is connected with the scraping mechanism after stretching into the bottom of the recrystallization cavity; the scraping mechanism comprises a second motor, a connecting plate, buffer plates and scraping plates, wherein the buffer plates are arranged on two sides of the bottom of the connecting plate, and the scraping plates are arranged at one ends of the buffer plates, which are far away from the connecting plate; the buffer plate is in a cuboid shape with an inner cavity provided with a sliding groove, one end of the scraping plate is in sliding connection with the sliding groove and is buffered through a spring in the sliding groove, and the other end of the scraping plate is provided with a circular scraping head which is in contact with the inner wall of the recrystallization cavity.
As a further scheme of the utility model, the connecting plate is cylindrical, the center of the upper surface of the connecting plate is provided with a first mounting hole, and two second mounting holes are symmetrically arranged on two sides of the first mounting hole; a motor shaft of the second motor is fixedly connected with the first mounting hole, and the end part of the telescopic shaft is rotatably connected with the bottom of the connecting plate; a third mounting hole is formed in the buffer plate in a penetrating mode, and the screw penetrates through the second mounting hole and the third mounting hole to enable the connecting plate to be fixedly connected with the buffer plate.
As a further proposal of the utility model, a heat preservation interlayer is arranged between the outer wall of the crystallizing tank body and the inner cavity, and the recrystallization cavity is in the shape of an inverted round platform and the top of the recrystallization cavity is connected with the active carbon filter plate.
As a further scheme of the utility model, the bottom in recrystallization chamber is equipped with liquid outlet and discharge gate, is equipped with second stop valve and third stop valve on liquid outlet and the discharge gate respectively.
As a further scheme of the utility model, all run through on connecting plate, buffer board, the scraping plate and be equipped with the through-hole.
The utility model has the advantages that:
1. the utility model discloses a N-acetyl-D-glucosamine recrystallization device, through setting up the crystallizer body, the inner chamber of the crystallizer body is equipped with from top to bottom and stirs dissolving chamber, filter chamber, recrystallization chamber; the top of the stirring and dissolving cavity is provided with an electric heating rod and a feed inlet which penetrate through the outer wall of the crystallization tank body; a first motor is arranged at the center of the top of the crystallizing tank body, a motor shaft of the first motor is connected with a stirring shaft extending into the stirring and dissolving cavity, a stirring blade is rotatably connected on the stirring shaft, and the bottom of the stirring and dissolving cavity is connected with the top of the filtering cavity through a first stop valve; an active carbon filter plate is arranged at the bottom of the filter cavity, active carbon is filled in the active carbon filter plate, a condensing pipe is wound on the outer wall of the recrystallization cavity, and circulating glacial ethanol is introduced into the condensing pipe; after the N-acetyl-D-glucosamine crude product is heated and dissolved by the solvent, the activated carbon filter plate further decolors and removes impurities from the crude product, so that the purity of the N-acetyl-D-glucosamine in the crude product solution is improved, and the yield and the purity of the N-acetyl-D-glucosamine in the recrystallization process are improved.
2. Through setting up the scraping mechanism, behind the most crystal material of discharge gate discharge, the second motor drive connecting plate, the buffer board, scrape the flitch and rotate, stretch out and draw back the cylinder simultaneously and drive the telescopic shaft, the connecting plate is flexible from top to bottom, under the cushioning effect of spring, circular scraping stub bar is continuously scraped at recrystallization intracavity wall, make the adhesion crystal on the inner wall discharge from the discharge gate, improved the yield of recrystallization on the one hand, on the other hand has reduced the cleaning cost in recrystallization chamber behind the crystal adhesion inner wall.
Drawings
The present invention will be further described with reference to the accompanying drawings.
FIG. 1 is a schematic structural diagram of the N-acetyl-D-glucosamine recrystallization device of the present invention.
Fig. 2 is a schematic view of the connection structure of the buffer plate and the scraper plate of the present invention.
Fig. 3 is a sectional view of the connection structure of the buffer plate and the scraper plate of the present invention.
Fig. 4 is a top view of the connection plate of the present invention.
In the figure: 1. a crystallization tank body; 2. stirring the dissolving cavity; 3. a filter chamber; 4. a recrystallization chamber; 5. a heat-insulating interlayer; 6. an electrical heating rod; 7. a feed inlet; 8. a first motor; 9. a stirring shaft; 10. stirring blades; 11. a first shut-off valve; 12. an activated carbon filter plate; 13. a liquid outlet; 14. a discharge port; 15. a second stop valve; 16. a third stop valve; 17. a condenser tube; 18. a jacking cylinder; 19. a telescopic shaft; 20. a second motor; 21. a connecting plate; 22. a buffer plate; 23. a scraping plate; 24. a first mounting hole; 25. a second mounting hole; 26. a spring; 27. a circular scraping head; 28. a third mounting hole; 29. a through hole; 30. a chute.
Detailed Description
The technical solutions in the embodiments of the present invention will be described clearly and completely with reference to the accompanying drawings in the embodiments of the present invention, and it is obvious that the described embodiments are only some embodiments of the present invention, not all embodiments. Based on the embodiments of the present invention, all other embodiments obtained by a person of ordinary skill in the art without creative efforts belong to the protection scope of the present invention.
Referring to fig. 1-4, the present embodiment provides an N-acetyl-D-glucosamine recrystallization apparatus, which includes a crystallization tank 1, wherein an inner cavity of the crystallization tank 1 is provided with a stirring and dissolving cavity 2, a filtering cavity 3, and a recrystallization cavity 4 from top to bottom, and a heat-insulating interlayer 5 is disposed between an outer wall of the crystallization tank 1 and the inner cavity. The top of the stirring and dissolving cavity 2 is provided with an electric heating rod 6 and a feed inlet 7 which penetrate through the outer wall of the crystallizing tank body 1. Wherein, the electric heating rod 6 adopts a single-head carbon fiber heating tube sold in the market. The top center of the crystallizer body 1 is provided with a first motor 8, the motor shaft of the first motor 8 is connected with a stirring shaft 9 extending into the stirring and dissolving cavity 2, the stirring shaft 9 is rotatably connected with a stirring blade 10, and the bottom of the stirring and dissolving cavity 2 is connected with the top of the filter cavity 3 through a first stop valve 11.
The bottom of filter chamber 3 is equipped with active carbon filter 12, and active carbon is filled in active carbon filter 12. The recrystallization chamber 4 is in the shape of an inverted circular truncated cone, the top of the recrystallization chamber is connected with the activated carbon filter plate 12, the bottom of the recrystallization chamber is provided with a liquid outlet 13 and a discharge port 14, and the liquid outlet 13 and the discharge port 14 are respectively provided with a second stop valve 15 and a third stop valve 16. The outer wall of the recrystallization cavity 4 is wound with a condensing pipe 17, and circulating glacial ethanol is introduced into the condensing pipe 17.
And a top extending cylinder 18 is arranged at the bottom of the crystallization tank body 1, and a telescopic shaft 19 of the top extending cylinder 18 extends from the bottom of the recrystallization cavity 4 and then is connected with a scraping mechanism. The scraping mechanism comprises a second motor 20, a connecting plate 21, a buffer plate 22 and a scraping plate 23, wherein the buffer plate 22 is arranged on two sides of the bottom of the connecting plate 21, and the scraping plate 23 is arranged at one end, far away from the connecting plate 21, of the buffer plate 22. The connecting plate 21 is cylindrical, a first mounting hole 24 is formed in the center of the upper surface of the connecting plate, and two second mounting holes 25 are symmetrically formed in two sides of the first mounting hole 24. The motor shaft of the second motor 20 is fixedly connected with the first mounting hole 24, and the end part of the telescopic shaft 19 is rotatably connected with the bottom of the connecting plate 21. The buffer plate 22 is a cuboid with an inner cavity provided with a sliding chute 30, one end of the scraping plate 23 is connected with the sliding chute 30 in a sliding way and is buffered by a spring 26 in the sliding chute 30, and the other end is provided with a round scraping head 27 which is contacted with the inner wall of the recrystallization chamber 4. The buffer plate 22 is provided with a third mounting hole 28, and the screw passes through the second mounting hole 25 and the third mounting hole 28 to fasten and connect the connecting plate 21 and the buffer plate 22. Through holes 29 are formed in the connecting plate 21, the buffer plate 22 and the scraper plate 23 in a penetrating mode.
The working method of the N-acetyl-D-glucosamine recrystallization device of the present embodiment is as follows:
(1) opening a first motor 8, adding the N-acetyl-D-glucosamine crude product and an ethanol solvent from a feeding hole 7, heating the ethanol to 30-40 ℃ by an electric heating rod 6, and driving a stirring blade 10 to rotate by a stirring shaft 9 to promote the complete dissolution of the N-acetyl-D-glucosamine crude product to generate an N-acetyl-D-glucosamine crude product solution;
(2) opening a first stop valve 11, allowing the N-acetyl-D-glucosamine crude product solution to enter a filter chamber 3, and performing decoloration and impurity removal on the crude product solution by an active carbon filter plate 12 to obtain an impurity removal solution;
(3) the impurity-removed solution enters a recrystallization cavity 4, and circulating glacial ethanol with the temperature of 0-5 ℃ is introduced into a condensation pipe 17 to separate out N-acetyl-D-glucosamine crystals; obtaining crystals after the N-acetyl-D-glucosamine is crystallized for 8 to 12 hours, opening a second stop valve 15, and discharging the ethanol from a liquid outlet 13;
(4) closing the second stop valve 15 and opening the third stop valve 16 to allow the crystal to be discharged from the discharge port 14; and (3) turning on the second motor 20, driving the connecting plate 21, the buffer plate 22 and the scraper plate 23 to rotate by the second motor 20, driving the telescopic shaft 19 and the connecting plate 21 to stretch up and down by the jacking cylinder 18, and continuously scraping the inner wall of the recrystallization chamber 4 by the circular scraper head 27 under the buffer action of the spring 26 so that crystals adhered to the inner wall are discharged from the discharge hole 14.
The foregoing is merely exemplary and illustrative of the structure of the invention, and various modifications, additions and substitutions as described in the detailed description may be made by those skilled in the art without departing from the structure or exceeding the scope of the invention as defined in the claims.
Claims (5)
1. An N-acetyl-D-glucosamine recrystallization device comprises a crystallization tank body (1), and is characterized in that a stirring and dissolving cavity (2), a filtering cavity (3) and a recrystallization cavity (4) are arranged in an inner cavity of the crystallization tank body (1) from top to bottom; the top of the stirring and dissolving cavity (2) is provided with an electric heating rod (6) and a feed inlet (7) which penetrate into the crystallization tank body (1) from the outer wall; a first motor (8) is arranged at the center of the top of the crystallizing tank body (1), a motor shaft of the first motor (8) is connected with a stirring shaft (9) extending into the stirring and dissolving cavity (2), a stirring blade (10) is rotatably connected on the stirring shaft (9), and the bottom of the stirring and dissolving cavity (2) is connected with the top of the filtering cavity (3) through a first stop valve (11);
an active carbon filter plate (12) is arranged at the bottom of the filter cavity (3), active carbon is filled in the active carbon filter plate (12), a condensing pipe (17) is wound on the outer wall of the recrystallization cavity (4), and circulating ice ethanol is introduced into the condensing pipe (17);
a top stretching cylinder (18) is arranged at the bottom of the crystallization tank body (1), and a telescopic shaft (19) of the top stretching cylinder (18) is connected with a scraping mechanism after stretching into the bottom of the recrystallization cavity (4); the scraping mechanism comprises a second motor (20), a connecting plate (21), buffer plates (22) and scraping plates (23), the buffer plates (22) are arranged on two sides of the bottom of the connecting plate (21), and the scraping plates (23) are arranged at one ends, far away from the connecting plate (21), of the buffer plates (22); the buffer plate (22) is in a cuboid shape with an inner cavity provided with a sliding chute (30), one end of the scraping plate (23) is in sliding connection with the sliding chute (30) and is buffered by a spring (26) in the sliding chute (30), and the other end of the scraping plate is provided with a round scraping head (27) which is in contact with the inner wall of the recrystallization cavity (4).
2. The N-acetyl-D-glucosamine recrystallization device according to claim 1, wherein the connecting plate (21) has a cylindrical shape and a first mounting hole (24) is formed in the center of the upper surface, and two second mounting holes (25) are symmetrically formed on both sides of the first mounting hole (24); a motor shaft of the second motor (20) is fixedly connected with the first mounting hole (24), and the end part of the telescopic shaft (19) is rotatably connected with the bottom of the connecting plate (21); a third mounting hole (28) penetrates through the buffer plate (22), and the screw penetrates through the second mounting hole (25) and the third mounting hole (28) to fixedly connect the connecting plate (21) with the buffer plate (22).
3. The N-acetyl-D-glucosamine recrystallization device according to claim 1, wherein a heat preservation interlayer (5) is arranged between the outer wall and the inner cavity of the crystallization tank body (1), the recrystallization cavity (4) is in an inverted round table shape, and the top of the recrystallization cavity is connected with an activated carbon filter plate (12).
4. The N-acetyl-D-glucosamine recrystallization device according to claim 1, wherein a liquid outlet (13) and a discharge outlet (14) are formed at the bottom of the recrystallization chamber (4), and a second stop valve (15) and a third stop valve (16) are respectively arranged on the liquid outlet (13) and the discharge outlet (14).
5. The N-acetyl-D-glucosamine recrystallization device according to claim 1, wherein the connecting plate (21), the buffer plate (22) and the scraper plate (23) are provided with through holes (29) in a penetrating manner.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202020734203.4U CN212236056U (en) | 2020-05-07 | 2020-05-07 | N-acetyl-D-glucosamine recrystallization device |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202020734203.4U CN212236056U (en) | 2020-05-07 | 2020-05-07 | N-acetyl-D-glucosamine recrystallization device |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN212236056U true CN212236056U (en) | 2020-12-29 |
Family
ID=73998051
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202020734203.4U Expired - Fee Related CN212236056U (en) | 2020-05-07 | 2020-05-07 | N-acetyl-D-glucosamine recrystallization device |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN212236056U (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113039000A (en) * | 2021-02-19 | 2021-06-25 | 安徽金禾实业股份有限公司 | Production equipment and production method of sucrose-6-ester |
-
2020
- 2020-05-07 CN CN202020734203.4U patent/CN212236056U/en not_active Expired - Fee Related
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113039000A (en) * | 2021-02-19 | 2021-06-25 | 安徽金禾实业股份有限公司 | Production equipment and production method of sucrose-6-ester |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN212236056U (en) | N-acetyl-D-glucosamine recrystallization device | |
| CN106621446A (en) | Chemical cooling crystallization kettle with stirring device | |
| CN213475989U (en) | Combined efficient anaerobic fermentation tank for producing alcohol by molasses | |
| CN213100902U (en) | Novel crystallization kettle capable of improving evaporation crystallization efficiency | |
| CN211612727U (en) | A reation kettle for extracting high-purity oleic acid | |
| CN110772830B (en) | Cold crystallizer for chemical production | |
| CN116875454A (en) | Process for extracting waste beer yeast cell wall polysaccharide by using enzymatic method | |
| CN215841710U (en) | Benzoic acid purification crystallization device | |
| CN219050384U (en) | Centrifugal separation recrystallization equipment for sodium acetate solid-liquid mixture | |
| CN112619200A (en) | Natural products polysaccharide draws concentrated all-in-one | |
| CN112474069A (en) | Novel multi-functional seed of job's tears processing centrifugal dehydration device | |
| CN215823799U (en) | Elutriation tank for refined salt crystallization | |
| CN210751375U (en) | A liquid collection tank for paeonol removes aldehyde liquid | |
| CN212269946U (en) | Propacetamol hydrochloride refining plant | |
| CN210705491U (en) | Gelatin melting tank for production of nutrition powder | |
| CN207734642U (en) | A kind of chemical industry crystallizing tank | |
| CN220860699U (en) | N-acetylneuraminic acid crystallization tank | |
| CN211357829U (en) | Decolorizing tank high in working efficiency | |
| CN220530715U (en) | Crystallization tank | |
| CN220695892U (en) | Crystallization device for chemical production | |
| CN214529082U (en) | Heating device for trehalose separation crystallization | |
| CN220648722U (en) | Cooling tank with anti-blocking mechanism for potassium nitrate transfer | |
| CN217887823U (en) | Crystal melting pool for honey production | |
| CN220834192U (en) | Freezing crystallizer | |
| CN220003012U (en) | Efficient cooling crystallization device |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| GR01 | Patent grant | ||
| GR01 | Patent grant | ||
| CF01 | Termination of patent right due to non-payment of annual fee | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20201229 Termination date: 20210507 |