CN212228483U - Multi-sequence reaction processor for detecting samples - Google Patents
Multi-sequence reaction processor for detecting samples Download PDFInfo
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- CN212228483U CN212228483U CN202020597289.0U CN202020597289U CN212228483U CN 212228483 U CN212228483 U CN 212228483U CN 202020597289 U CN202020597289 U CN 202020597289U CN 212228483 U CN212228483 U CN 212228483U
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Abstract
The utility model discloses a multi-sequence reaction processor for detecting samples, which comprises a sleeve, wherein one end of the sleeve is closed, a liquid storage module is arranged in the sleeve in a sliding way, and the liquid storage module is in airtight fit with the inner wall of the sleeve to form an airtight chamber between the liquid storage module and the sleeve; the liquid storage module is connected with a sample processing module which is positioned in the airtight chamber and communicated with the airtight chamber; at least two liquid storage cavities are arranged in the liquid storage module and communicated with the atmosphere, all the liquid storage cavities are connected with the same switch module, and the switch module is used for communicating only one of the liquid storage cavities with the sample processing module. The utility model has the advantages that: utilize atmospheric pressure difference's effect to replace common external centrifugal treatment to drive liquid and flow, it is simple to use, simply realize the multistep processing of sample in same device, convenient to use, efficient, the device integrated level is high, is applicable to the processing of trace sample.
Description
Technical Field
The utility model belongs to the technical field of external detection device, concretely relates to detect sample multi-sequence reaction processor.
Background
In vitro diagnosis is a technique of obtaining clinical diagnostic information by detecting a human body sample in vitro, such as blood, body fluid, tissue, etc., to determine a disease or a body function. The target substance to be detected may be a macromolecule such as a protein or a nucleic acid, and may be present in a body fluid or may be present in a cell. Because the components of the sample are complex, the sample is often required to be centrifuged, adsorbed and desorbed or separated and purified by other operations, and even required to be sequentially reacted with various reagents to form a sample to be detected which can be directly detected on an instrument, and then the sample is sent into the instrument for detection. For example, in some assays, a human body sample is added into a centrifuge tube, a sample carrier is placed in the centrifuge tube, a target or a detection interfering substance is loaded on the sample carrier by centrifugation, and then a subsequent reaction reagent is added for reaction. This operation process is loaded down with trivial details, and when the sample quantity that detects is more, need a large amount of centrifuges to carry out centrifugal treatment, and the equal time that consumes of the interpolation of reagent, the transfer of sample, and operating efficiency is low, and is with high costs.
SUMMERY OF THE UTILITY MODEL
In view of this, the present invention provides a multi-sequence reaction processor for detecting samples, which replaces the centrifugal operation and adds a human body sample to load a target object on a filter paper or react with a test paper.
The technical scheme is as follows:
the multi-sequence reaction processor for detecting samples is characterized by comprising a sleeve, wherein one end of the sleeve is closed, a liquid storage module is arranged in the sleeve in a sliding mode, and the liquid storage module is in airtight fit with the inner wall of the sleeve to form an airtight chamber between the liquid storage module and the sleeve;
the liquid storage module is connected with a sample processing module which is positioned in the airtight chamber and communicated with the airtight chamber;
at least two liquid storage cavities are arranged in the liquid storage module, all the liquid storage cavities are connected with the same switch module, and the switch module is used for communicating the liquid storage cavity with the sample processing module only by one at a time.
By adopting the design, the liquid sample or the detection reagent is filled into the liquid storage cavity, the liquid storage cavity is communicated with the atmosphere, after the switch module communicates a certain liquid storage cavity with the sample processing module, when the liquid storage module slides outwards the sleeve pipe manually, the air pressure in the airtight chamber is reduced to be less than the external atmospheric pressure, the liquid sample or the reagent in the liquid storage cavity enters the sample processing module under the driving of the air pressure difference so as to react, due to the higher pressure, the process can play the role of treating the sample by centrifugation in vitro, different samples or reagents enter the sample processing module successively by controlling the switch module, the waste liquid is stored in the airtight chamber, the multi-step treatment of the sample is simply realized in the same device, the use is convenient, and the efficiency is high.
As a preferred technical scheme, the liquid storage module comprises a liquid storage pipe, the bottom of the liquid storage pipe is close to the back cover of the sleeve, and the outer wall of the liquid storage pipe is in sliding airtight fit with the inner wall of the sleeve;
the bottom of the liquid storage pipe is connected with the sample processing module;
at least two liquid storage cavities are distributed in the liquid storage tube side by side, each liquid storage cavity is provided with a liquid outlet, and the liquid outlets are respectively arranged at the bottom of the liquid storage tube and connected with the sample processing module through the switch module;
the switch module is connected with a switch operating piece, and the switch operating piece penetrates through the liquid storage pipe and then extends out of the opening of the sleeve.
By adopting the design, the liquid in different liquid storage cavities can be easily controlled to flow to the sample processing module by operating the switch operating part.
As a preferred technical scheme, the liquid storage pipe is provided with an interlayer, the section of the liquid storage pipe is in a circular ring shape, and an interlayer cavity of the liquid storage pipe is annularly divided into at least two liquid storage cavities;
all the liquid outlets are distributed around the tube axis of the liquid storage tube;
the switch module comprises a valve cylinder and a valve plate, the outer-layer pipe wall of the liquid storage pipe extends towards the back cover of the sleeve to form the valve cylinder, the valve cylinder is communicated with the sample processing module, the valve plate is rotationally arranged in the valve cylinder, the valve plate is clamped between the bottom of the liquid storage cavity and the switch module, and the valve plate is attached to the bottom of the liquid storage cavity to seal the liquid outlet;
the valve plate is provided with a liquid passing hole, and when the valve plate rotates until the liquid passing hole is opposite to any liquid outlet, the liquid outlet is communicated with the sample processing module;
the switch operating part is a valve rod, the valve rod is connected with the valve plate, the valve rod extends out of an inner hole of the liquid storage pipe, and the valve rod is in running fit with the inner pipe wall of the liquid storage pipe.
By adopting the design, the valve plate is driven to rotate by rotating the valve rod, so that the liquid passing holes are communicated with the liquid outlet one by one, and the whole switch module is simple in structure, good in matching with the liquid storage pipe and compact in structure.
According to the preferable technical scheme, a diaphragm is attached to the bottom of the liquid storage pipe, the diaphragm is clamped between the bottom of the liquid storage pipe and a valve plate, and liquid outlet one-way valves are formed on the diaphragm corresponding to the liquid outlets respectively.
By adopting the design and arranging the liquid outlet one-way valve, the liquid in the airtight chamber can be prevented from flowing back into the liquid storage cavity, and the liquid in the liquid storage cavity can be prevented from flowing into the sample processing module when the liquid is not influenced by the internal and external pressure difference.
As a preferred technical scheme, the sample processing module comprises a filter tube, one end of the filter tube is hermetically connected with the valve cylinder and tightly supports the valve plate against the bottom of the liquid storage cavity, the other end of the filter tube is provided with a load orifice plate, a sample carrier is arranged on the load orifice plate, and a carrier outlet hole is formed in the wall of the filter tube corresponding to the sample carrier.
By adopting the design, the liquid flows through the sample carrier under the action of the air pressure difference without centrifugal treatment, so that the target object or the detection interfering object in the sample is trapped on the sample carrier, and the sample carrier is easy to take out.
As a preferred technical scheme, a push rod hole is formed in the pipe wall of the filter pipe, which is opposite to the carrier outlet hole;
a sampling push rod is arranged corresponding to the push rod hole, one end of the sampling push rod is connected with the outer wall of the filter pipe, and the other end of the sampling push rod extends into the push rod hole from the outer side.
Design more than adopting, when the sample carrier of target thing after will pretreating the back load is put into the instrument and is detected, take off the sleeve pipe, manual stirring sample push rod can take out the sample carrier, and convenient operation avoids polluting the sample carrier when getting the sample carrier with other article.
As a preferred technical scheme, a sliding driving mechanism is arranged between the sleeve and the liquid storage pipe;
the sliding driving mechanism comprises an annular shifting wheel, the shifting wheel is rotatably arranged at the opening end of the sleeve, and the shifting wheel is sleeved outside the liquid storage pipe in a sleeving manner and is in threaded fit with the liquid storage pipe.
By adopting the design, the shifting wheel and the liquid storage pipe are in a screw nut structure, and the shifting wheel is shifted to easily drive the liquid storage pipe to rotate and slide outwards the sleeve, so that the air pressure of the airtight chamber is reduced.
As a preferred technical scheme, the open end of the sleeve is connected with an installation cylinder, the installation cylinder and the sleeve are arranged in a concentric line mode, the inner diameter of the installation cylinder is larger than that of the sleeve, and the installation cylinder and the open end of the sleeve are fixedly connected through a connecting ring;
an anti-drop ring is arranged in the mounting cylinder, and the dial wheel is clamped between the anti-drop ring and the connecting ring;
a thumb wheel window is arranged on the mounting cylinder corresponding to the thumb wheel;
after the opening of the liquid storage pipe extends out of the shifting wheel, the outer surface of the outer pipe wall of the liquid storage pipe is connected with a limiting ring.
By adopting the design, the mounting structure of the thumb wheel is simple, and the limiting ring is arranged to prevent the liquid storage cylinder from transitionally entering the sleeve.
As a preferred technical scheme, a sample adding hole penetrates through the valve rod along the axial direction of the valve rod, the inner end of the sample adding hole penetrates out of the valve plate, and the outer end of the sample adding hole and the opening of the liquid storage pipe are covered with the same rubber plug in a buckling manner;
the rubber plug comprises a thin-wall puncture part which is opposite to the sampling hole;
and the liquid storage pipe is provided with an air inlet one-way valve corresponding to each liquid storage cavity respectively, and the air inlet one-way valve is used for communicating the liquid storage cavities with the outside.
Design more than adopting sets up the plug, can be in stock solution intraductal pre-installation reagent, is convenient for preserve the transportation, sets up the check valve that admits air and neither influences stock solution chamber and external atmosphere intercommunication, can prevent again that the pre-installation reagent from spilling over, sets up thin wall puncture portion, is convenient for add the human sample that waits to detect through it in to the loading hole.
As a preferred technical scheme, a sealing ring is clamped between the outer wall of the liquid storage pipe and the inner wall of the sleeve;
an annular groove is formed in the outer wall of the liquid storage pipe, the annular groove is close to the bottom of the liquid storage pipe, and the sealing ring is sleeved in the annular groove in a clamping mode;
and a cavity enclosed among the sealing ring, the liquid storage pipe and the sleeve forms the airtight chamber.
By adopting the design, the sealing structure is simple and reliable.
Compared with the prior art, the beneficial effects of the utility model are that: (1) the liquid sample or the detection reagent is driven to enter the sample processing module for processing by utilizing the action of the air pressure difference between the inside and the outside of the liquid storage cavity, so that the centrifugal processing step is replaced, the transfer of the sample among devices is avoided, and the use is simple; (2) different samples or reagents enter the sample processing module in sequence by controlling the switch module, and waste liquid is stored in the airtight chamber, so that multi-step processing of the samples is simply and conveniently realized in the same device, and the device is convenient to use and high in efficiency; (3) the device has high integration level and is suitable for processing trace samples.
Drawings
Fig. 1 is a schematic view of the overall structure of the present invention;
fig. 2 is a cross-sectional view in a first direction of the present invention;
FIG. 3 is an enlarged view of the portion m1 in FIG. 2;
FIG. 4 is an enlarged view of the portion m2 in FIG. 2;
fig. 5 is a cross-sectional view in another direction (perpendicular to fig. 2) of the present invention;
FIG. 6 is an enlarged view of the portion m3 in FIG. 5;
FIG. 7 is a schematic view of FIG. 1 with the sleeve removed;
FIG. 8 is an exploded view of FIG. 7;
FIG. 9 is an exploded view of FIG. 7 from another perspective;
fig. 10 is an exploded view of fig. 7 from a third perspective.
Detailed Description
The present invention will be further described with reference to the following examples and accompanying drawings.
As shown in fig. 1 to 10, a multi-sequence reaction processor for detecting a sample includes a sleeve 100, one end of the sleeve 100 is closed, a liquid storage module 200 is slidably disposed in the sleeve 100, and the liquid storage module 200 is hermetically engaged with an inner wall of the sleeve 100 to form an airtight chamber 101 therebetween. A sample processing module 400 is connected to the reservoir module 200, the sample processing module 400 being located within and in communication with the hermetic chamber 101.
At least two liquid storage cavities 220 are arranged in the liquid storage module 200, all the liquid storage cavities 220 are connected with the same switch module 300, and the switch module 300 is used for communicating only one liquid storage cavity 220 with the sample processing module 400 at a time. When one of the liquid storage cavities 220 communicates with the sample processing module 400, the liquid storage cavity 220 communicates with the atmosphere, and the liquid storage module 200 is pulled outward, so that the air pressure of the airtight chamber 101 is reduced to be lower than the external atmospheric pressure, and the liquid stored in the liquid storage cavity 220 is pressed into the sample processing module 400 by the pressure difference between the inside and the outside.
Specifically, as shown in fig. 2, the reservoir module 200 includes a reservoir tube 210, a bottom of the reservoir tube 210 is close to the back cover of the sleeve 100, and an outer wall of the reservoir tube 210 is in sliding airtight fit with an inner wall of the sleeve 100. The sample processing module 400 is connected to the bottom of the reservoir tube 210. At least two liquid storage cavities 220 are distributed in the liquid storage tube 210 side by side, each liquid storage cavity 220 is provided with a liquid outlet 221, the liquid outlets 221 are respectively arranged at the bottom of the liquid storage tube 210, and are connected with the sample processing module 400 through the switch module 300. The switch module 300 is connected with a switch operator, which extends out of the opening of the cartridge 100 after passing through the reservoir tube 210.
As a specific embodiment, the liquid storage pipe 210 has an interlayer, the cross section of the liquid storage pipe 210 is circular, and the interlayer cavity of the liquid storage pipe 210 is annularly divided into at least two liquid storage cavities 220. All the liquid outlets 221 are distributed around the centerline of the liquid storage tube 210. In this embodiment, as shown in fig. 9, 3 liquid storage cavities 220 are disposed in the liquid storage tube 210.
As shown in fig. 3, 6 and 10, the switch module 300 includes a valve cylinder 310 and a valve plate 320, an outer wall of the liquid storage tube 210 extends toward the back cover of the sleeve 100 to form the valve cylinder 310, the valve cylinder 310 is communicated with the sample processing module 400, the valve plate 320 is rotatably disposed in the valve cylinder 310, the valve plate 320 is sandwiched between the bottom of the liquid storage cavity 220 and the switch module 300, and the valve plate 320 abuts against the bottom of the liquid storage cavity 220 to close the liquid outlet 221. The valve plate 320 is provided with a liquid passing hole 321, and when the valve plate 320 rotates until the liquid passing hole 321 faces any one of the liquid outlets 221, the liquid outlet 221 is communicated with the sample processing module 400.
As shown in fig. 7 to 9, the switch operating member is a valve stem 330, the valve stem 330 is connected to the valve plate 320, the valve stem 330 extends from the inner hole of the liquid storage tube 210, and the valve stem 330 is rotatably engaged with the inner wall of the liquid storage tube 210. The valve rod 330 is manually rotated to drive the valve plate 320 to rotate in the valve cylinder 310, so that the liquid passing holes 321 sequentially face the liquid outlets 221, and when the liquid passing holes 321 are located at various positions, the liquid storage tube 210 is pulled outwards, so that the liquid in the opened liquid storage tube 210 enters the sample processing module 400 under the action of air pressure. In order to facilitate accurate alignment, the valve rod 330 may be provided with an orientation mark of the liquid passing hole 321, and the liquid storage tube 210 may be provided with a position mark of each liquid outlet 221 to assist an operator in determining.
Further, in order to prevent the liquid from flowing back, a membrane 240 is attached to the bottom of each liquid storage tube 210, the membrane 240 is sandwiched between the bottom of the liquid storage tube 210 and a valve plate 320, a liquid outlet check valve 241 is respectively formed on the membrane 240 corresponding to each liquid outlet 221, and the liquid outlet check valve 241 is opened only when the pressure difference acts on the membrane 240, so as to allow the liquid to flow into the sample processing module 400 from the liquid outlet 221, and block the reverse flow of the liquid. The structure of the diaphragm 240 and the upper liquid outlet check valve 241 thereof is disclosed in the prior art, such as a T-shaped elastic diaphragm described in patent CN 207552287U.
As shown in fig. 3, the sample processing module 400 includes a filter tube 410, one end of the filter tube 410 is hermetically connected to the valve cartridge 310 and abuts against the valve plate 320 at the bottom of the reservoir 220, the other end of the filter tube 410 is provided with a load hole plate 420, and the load hole plate 420 is provided with a sample carrier 440. The inner cavity of the filter tube 410 is further provided with a limiting orifice plate 430, and the limiting orifice plate 430 and the loading orifice plate 420 are respectively positioned at two sides of the sample carrier 440. Under the action of the air pressure difference, the liquid flows through the sample carrier 440, and the target is trapped on the sample carrier 440 for subsequent reagent addition and processing. This procedure works equally well as the prior art method of processing samples by centrifugation, but is greatly simplified. The sample carrier 440 may be filter paper.
The filter tube 410 comprises a tube body 411, the tube body 411 is provided with a butt joint ring 412 corresponding to the outer wall of one end of the valve cylinder 310, the butt joint ring 412 is connected with the valve cylinder 310 through bonding or hot melting for sealing, the butt joint ring 412 is provided with a butt joint ring 413, one side of the butt joint ring 413 is connected with the butt joint ring 412 in a fitting manner, the other side of the butt joint ring 412 abuts against the valve plate 320, the outer circumferential surface of the butt joint ring 413 abuts against the inner wall of the valve cylinder 310, a sample feeding chamber is defined by the butt joint ring 412, and the sample feeding chamber communicates the liquid passing hole 321 with the inner cavity of the filter tube 410.
A carrier outlet 450 is formed in the wall of the filter tube 410 corresponding to the sample carrier 440, so that the sleeve can be removed after the sample is processed, and the sample carrier 440 can be taken out. A push rod hole 460 is formed on the pipe wall of the filter pipe 410 opposite to the carrier outlet hole 450. A sampling push rod 470 is disposed corresponding to the push rod hole 460, one end of the sampling push rod 470 is connected to the outer wall of the filter tube 410, and the other end extends into the push rod hole 460 from the outside.
The sampling push rod 470 comprises an embedded section 471 and a V-shaped section 472, the embedded section 471 is embedded in the outer wall of the filter tube 410, the embedded section 471 is connected with one end of the V-shaped section 472, and the other end of the V-shaped section 472 freely extends into the push rod hole 460. The sampling push rod 470 is formed by bending the same rod twice in opposite directions.
The concrete mounting means of sample push rod does: offer the groove of stepping down 480 on the filter tube 410 outer wall, should step down groove 480 with push rod hole 460 intercommunication is being close to this groove of stepping down 480 be equipped with the embedding hole on the filter tube 410 outer wall, this embedding hole opening in the groove of stepping down 480 department. The embedding section 471 is inserted into the embedding hole, the fixed end of the V-shaped section 472 is close to the receding groove 480, and the free end of the V-shaped section 472 passes through the receding groove 480 and abuts against the hole wall of the push rod hole 460.
The airtight chamber 101 can be directly and manually pulled outwards to generate negative pressure, or can be driven by other driving methods to facilitate operation. In this embodiment, a sliding driving mechanism is disposed between the sleeve 100 and the liquid storage tube 210. As shown in fig. 4 and 5, the sliding driving mechanism includes a ring-shaped wheel 500, the wheel 500 is rotatably mounted on the open end of the sleeve 100, and the wheel 500 is sleeved on the outside of the reservoir 210 and is threadedly engaged with the reservoir. Specifically, the outer wall of the liquid storage pipe 210 is provided with an external thread, and the inner wall of the thumb wheel 500 is provided with an internal thread matched with the internal thread.
The open end of the sleeve 100 is connected with a mounting cylinder 510, the mounting cylinder 510 is arranged coaxially with the sleeve 100, the inner diameter of the mounting cylinder 510 is larger than that of the sleeve 100, and the mounting cylinder 510 is fixedly connected with the open end of the sleeve 100 through a connecting ring 511. A retaining ring 512 is provided in the mounting tube 510, and the dial wheel 500 is interposed between the retaining ring 512 and the connection ring 511. A thumb wheel window 513 is formed on the mounting cylinder 510 corresponding to the thumb wheel 500. After the opening of the liquid storage tube 210 extends out of the thumb wheel 500, the outer surface of the outer tube wall is connected with a limiting ring 230.
As shown in fig. 4, a sample adding hole 331 is formed through the valve rod 330 along the axial direction thereof, the inner end of the sample adding hole 331 penetrates through the valve plate 320, and the outer end of the sample adding hole 331 and the opening of the liquid storage tube 210 are covered with the same rubber plug 600. The outer wall of the valve rod 330 is further provided with a clamping groove 332, the rubber plug 600 is provided with a clamping flange 602 corresponding to the clamping groove 332, and the clamping flange 602 is embedded into the clamping groove 332.
One use mode of the device is that reagent is added into the liquid storage cavity 220, the collected liquid human body sample is injected through the sample adding hole 331 and directly enters the filter pipe 410, then various reagents are sequentially injected into the filter pipe 410 through the negative pressure effect, and the sample treatment is completed in the filter pipe 410.
Another use mode of the device is that a liquid human body sample is added into any one of the liquid storage cavities 220, reaction reagents are added into the other liquid storage cavities 220, and then the liquid in each liquid storage cavity 220 is sequentially added into the filter pipe 410 according to the processing steps.
In a third application of the device, the liquid storage chamber 220 is pre-filled with a reagent, and after the whole device is packaged, an independent sample processing system is formed. In this case, the rubber plug 600 includes a thin-walled piercing portion 601, and the thin-walled piercing portion 601 faces the sample addition hole 331. The liquid storage pipe 210 is provided with a gas inlet one-way valve 222 corresponding to each liquid storage cavity 220, the liquid storage cavities 220 are communicated with the outside through the gas inlet one-way valves 222, and the gas inlet one-way valves 222 can prevent pre-loaded reagents from overflowing from the liquid storage cavities 220, so that the whole device is convenient to store and transport. The structure of the air inlet check valve 222 is the same as that of the liquid outlet check valve 241. When in use, the collected liquid human body sample is injected by the syringe through the thin-wall puncture part 601. The human sample flows through the filter tube 410 and is filtered from the sample carrier 440, and the step of manually rotating the thumb wheel 500 to move the reservoir tube 210 outward for pressurization, if desired. Next, the valve rod 330 is rotated to gradually release the pre-loaded reagents in each of the reservoirs 220 into the reservoir 210 for interaction with the sample carrier 440.
One airtight fit of the reservoir tube 210 and the sleeve 100 is: as shown in fig. 6, a sealing ring 102 is interposed between an outer wall of the reservoir tube 210 and an inner wall of the sleeve 100. An annular groove is formed in the outer wall of the liquid storage pipe 210, the annular groove is close to the bottom of the liquid storage pipe 210, and the sealing ring 102 is clamped in the annular groove. The cavity enclosed between the sealing ring 102 and the liquid storage tube 210 and the sleeve 100 forms the airtight chamber 101.
Finally, it should be noted that the above description is only a preferred embodiment of the present invention, and those skilled in the art can make various similar representations without departing from the spirit and the scope of the present invention.
Claims (10)
1. A processor for detecting the multi-sequence reaction of a sample is characterized in that: the device comprises a sleeve (100), wherein one end of the sleeve (100) is closed, a liquid storage module (200) is arranged in the sleeve (100) in a sliding mode, and the liquid storage module (200) is in airtight fit with the inner wall of the sleeve (100) to form an airtight chamber (101) between the liquid storage module and the sleeve;
a sample processing module (400) is connected to the reservoir module (200), the sample processing module (400) being located within and in communication with the hermetic chamber (101);
at least two liquid storage cavities (220) are arranged in the liquid storage module (200), all the liquid storage cavities (220) are connected with the same switch module (300), and the switch module (300) is used for communicating only one liquid storage cavity (220) with the sample processing module (400) at a time.
2. The processor for multi-sequence reaction of test samples according to claim 1, wherein: the liquid storage module (200) comprises a liquid storage pipe (210), the bottom of the liquid storage pipe (210) is close to the back cover of the sleeve (100), and the outer wall of the liquid storage pipe (210) is in sliding airtight fit with the inner wall of the sleeve (100);
the bottom of the liquid storage pipe (210) is connected with the sample processing module (400);
at least two liquid storage cavities (220) are distributed in the liquid storage tube (210), each liquid storage cavity (220) is provided with a liquid outlet (221), the liquid outlets (221) are respectively arranged at the bottom of the liquid storage tube (210) and are connected with the sample processing module (400) through the switch module (300);
the switch module (300) is connected with a switch operating piece which passes through the liquid storage pipe (210) and then extends out of the opening of the sleeve (100).
3. The processor for multi-sequence reaction of test samples according to claim 2, wherein: the liquid storage pipe (210) is provided with an interlayer, the section of the liquid storage pipe (210) is circular, and the interlayer cavity of the liquid storage pipe (210) is annularly divided into at least two liquid storage cavities (220);
all the liquid outlets (221) are distributed around the tube axis of the liquid storage tube (210);
the switch module (300) comprises a valve cylinder (310) and a valve plate (320), the outer-layer pipe wall of the liquid storage pipe (210) extends towards the back cover of the sleeve (100) to form the valve cylinder (310), the valve cylinder (310) is communicated with the sample processing module (400), the valve plate (320) is rotationally arranged in the valve cylinder (310), the valve plate (320) is clamped between the bottom of the liquid storage cavity (220) and the switch module (300), and the valve plate (320) is attached to the bottom of the liquid storage cavity (220) to seal the liquid outlet (221);
the valve plate (320) is provided with a liquid passing hole (321), and when the valve plate (320) rotates until the liquid passing hole (321) is opposite to any one of the liquid outlets (221), the liquid outlet (221) is communicated with the sample processing module (400);
the switch operating member is a valve rod (330), the valve rod (330) is connected with the valve plate (320), the valve rod (330) extends out of an inner hole of the liquid storage pipe (210), and the valve rod (330) is in rotating fit with the inner layer pipe wall of the liquid storage pipe (210).
4. The processor for multi-sequence reaction of test samples according to claim 3, wherein: the bottom of the liquid storage pipe (210) is attached with a diaphragm (240), the diaphragm (240) is clamped between the bottom of the liquid storage pipe (210) and a valve plate (320), and liquid outlet one-way valves (241) are respectively formed on the diaphragm (240) corresponding to each liquid outlet (221).
5. The processor for multi-sequence reaction of test samples according to claim 3, wherein: the sample processing module (400) comprises a filter pipe (410), one end of the filter pipe (410) is hermetically connected with the valve barrel (310) and tightly supports the valve plate (320) against the bottom of the liquid storage cavity (220), the other end of the filter pipe (410) is provided with a load pore plate (420), a sample carrier (440) is arranged on the load pore plate (420), and a carrier outlet hole (450) is formed in the pipe wall of the filter pipe (410) corresponding to the sample carrier (440).
6. The processor for multi-sequence reaction of test samples according to claim 5, wherein: a push rod hole (460) is formed in the pipe wall of the filter pipe (410) opposite to the carrier outlet hole (450);
a sampling push rod (470) is arranged corresponding to the push rod hole (460), one end of the sampling push rod (470) is connected with the outer wall of the filter pipe (410), and the other end of the sampling push rod extends into the push rod hole (460) from the outer side.
7. The processor for multi-sequence reaction of test samples according to any one of claims 3 to 6, characterized in that: a sliding driving mechanism is arranged between the sleeve (100) and the liquid storage pipe (210);
the sliding driving mechanism comprises an annular thumb wheel (500), the thumb wheel (500) is rotatably arranged at the opening end of the sleeve (100), and the thumb wheel (500) is sleeved outside the liquid storage pipe (210) in a sleeved mode and is in threaded fit with the liquid storage pipe.
8. The processor for multi-sequence reaction of test samples according to claim 7, wherein: the open end of the sleeve (100) is connected with an installation cylinder (510), the installation cylinder (510) and the sleeve (100) are arranged in a concentric line mode, the inner diameter of the installation cylinder (510) is larger than that of the sleeve (100), and the installation cylinder (510) and the open end of the sleeve (100) are fixedly connected through a connecting ring (511);
a drop-off prevention ring (512) is arranged in the mounting cylinder (510), and the dial wheel (500) is clamped between the drop-off prevention ring (512) and the connecting ring (511);
a thumb wheel window (513) is arranged on the mounting cylinder (510) corresponding to the thumb wheel (500);
after the opening of the liquid storage pipe (210) extends out of the thumb wheel (500), the outer surface of the outer layer pipe wall of the liquid storage pipe is connected with a limiting ring (230).
9. The processor for multi-sequence reaction of test samples according to claim 8, wherein: a sample adding hole (331) penetrates through the valve rod (330) along the axial direction of the valve rod, the inner end of the sample adding hole (331) penetrates out of the valve plate (320), and the outer end of the sample adding hole (331) and the opening of the liquid storage pipe (210) are covered with the same rubber plug (600) in a buckling manner;
the rubber plug (600) comprises a thin-wall puncture part (601), and the thin-wall puncture part (601) is opposite to the sample adding hole (331);
the liquid storage pipe (210) is provided with an air inlet one-way valve (222) corresponding to each liquid storage cavity (220), and the air inlet one-way valve (222) is used for communicating the liquid storage cavities (220) with the outside.
10. The processor for multi-sequence reaction of test samples according to claim 2, wherein: a sealing ring (102) is clamped between the outer wall of the liquid storage pipe (210) and the inner wall of the sleeve (100);
an annular groove is formed in the outer wall of the liquid storage pipe (210), the annular groove is close to the bottom of the liquid storage pipe (210), and the sealing ring (102) is sleeved in the annular groove in a clamping mode;
the cavity enclosed by the sealing ring (102), the liquid storage tube (210) and the sleeve (100) forms the airtight chamber (101).
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2020201404906 | 2020-01-21 | ||
| CN202020140490 | 2020-01-21 |
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| CN212228483U true CN212228483U (en) | 2020-12-25 |
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| CN202020597289.0U Active CN212228483U (en) | 2020-01-21 | 2020-04-20 | Multi-sequence reaction processor for detecting samples |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112760208A (en) * | 2020-12-31 | 2021-05-07 | 苏州安基生物科技有限公司 | Constant-temperature PCR reaction tube and use method thereof |
| CN117046388A (en) * | 2023-10-12 | 2023-11-14 | 四川大学华西医院 | Device for high-pressure oxidation experiment of protein crystal |
| CN117046388B (en) * | 2023-10-12 | 2024-05-24 | 四川大学华西医院 | Device for high-pressure oxidation experiment of protein crystal |
-
2020
- 2020-04-20 CN CN202020597289.0U patent/CN212228483U/en active Active
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112760208A (en) * | 2020-12-31 | 2021-05-07 | 苏州安基生物科技有限公司 | Constant-temperature PCR reaction tube and use method thereof |
| CN117046388A (en) * | 2023-10-12 | 2023-11-14 | 四川大学华西医院 | Device for high-pressure oxidation experiment of protein crystal |
| CN117046388B (en) * | 2023-10-12 | 2024-05-24 | 四川大学华西医院 | Device for high-pressure oxidation experiment of protein crystal |
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