CN212126108U

CN212126108U - Beta 2-microglobulin determination kit

Info

Publication number: CN212126108U
Application number: CN202020855106.0U
Authority: CN
Inventors: 涂小宁; 范翠翠; 周钫英; 许国和
Original assignee: Ningbo Purebio Biotechnology Co ltd
Current assignee: Ningbo Purebio Biotechnology Co ltd
Priority date: 2020-05-20
Filing date: 2020-05-20
Publication date: 2020-12-11
Anticipated expiration: 2030-05-20

Abstract

The utility model discloses a beta 2-microglobulin determination kit. The beta 2-microglobulin determination kit comprises a packaging box and a reagent bottle matched with the packaging box: the reagent bottle includes: the bottle body comprises an accommodating space and a mounting hole communicated with the accommodating space. The rubber spare, including sealed hole and edge the radial seal in sealed hole the deformation membrane in sealed hole, the deformation membrane includes from the center to the seam of meeting an emergency that the pore wall direction in sealed hole extends. The rubber piece is arranged in the mounting hole, and the sealing hole is communicated to the accommodating space. And the bottle cap is detachably arranged on the bottle body and seals the opening of the mounting hole. The rubber spare is installed in the bottle and is located the mounting hole, and the sealed hole is sealed to the deformation membrane to the contact of separation accommodation space and outside air. The deformation membrane is inserted at the straw piece of check out test set back along the crooked deformation of seam that meets an emergency to keep accommodation space airtight, reagent stability is good.

Description

Beta 2-microglobulin determination kit

Technical Field

The utility model belongs to the technical field of detect technique and specifically relates to a beta 2-microglobulin assay kit.

Background

Beta 2-microglobulin (beta 2-MG) is a protein present on the surface of human lymphocytes and other nucleated cells. Free β 2-MG is filtered through the glomerulus and then reabsorbed in the proximal tubule of the kidney. Increased urinary β 2-MG secretion is a sensitive indicator of renal insufficiency.

The reagent bottle has a container structure for containing a liquid reagent for detection. However, the reagent in the reagent bottle is exposed to the atmosphere after the bottle cap is opened, or is exposed to the air during the reagent extraction process of the instrument, so that substances suspended in the air enter the reagent bottle, the reagent is polluted, and the detection accuracy is affected, so that the improvement is needed.

SUMMERY OF THE UTILITY MODEL

The utility model aims at providing a beta 2-microglobulin determination kit.

The utility model discloses the first aspect of the technical scheme who adopts is: a beta 2-microglobulin determination kit comprises a packaging box and a reagent bottle matched with the packaging box; the reagent bottle includes:

the bottle body comprises an accommodating space and a mounting hole communicated with the accommodating space;

the rubber piece comprises a sealing hole and a deformation film which seals the sealing hole along the radial direction of the sealing hole, the deformation film comprises a strain seam which extends from the center to the hole wall direction of the sealing hole, the rubber piece is installed in the installation hole, and the sealing hole is communicated with the accommodating space;

and the bottle cap is detachably arranged on the bottle body and seals the opening of the mounting hole.

Optionally, the deformation membrane is located away from the opening where the mounting hole intersects with the outer peripheral wall of the bottle body.

Optionally, the rubber piece includes a guide portion disposed at an opening of the sealing hole, the guide portion is inclined toward the opening of the mounting hole, and the guide portion is an inclined surface or a curved surface.

Optionally, the mounting hole includes first step hole, second step hole, certainly joint portion that the partial protrusion of pore wall of first step hole formed, be located first step hole with the crossing step face of second step hole, the aperture in first step hole is greater than the aperture in second step hole, the rubber spare install in first step hole and be injectd in joint portion with between the step face.

Optionally, the clamping portion comprises an annular rib, and the annular rib comprises an inclined plane inclined towards the sealing hole of the rubber piece.

Optionally, the diameter of the second stepped hole is larger than that of the sealing hole.

Optionally, the reagent bottle further comprises a covering film for closing the mounting hole, and the covering film covers an opening of the mounting hole intersecting with the outer peripheral wall of the bottle body to close the accommodating space.

Optionally, the bottle includes vessel and tubulose protrusion the installation department of vessel, the mounting hole is located the installation department, the tectorial membrane cladding in the tip of installation department, the bottle lid with the connection can be dismantled to the installation department.

Optionally, the peripheral wall of the container body is provided with an elongated transparent portion extending from the bottom of the container body toward the mounting portion.

After the structure is adopted, compared with the prior art, the utility model the advantage that has is: the rubber spare is installed in the bottle and is located the mounting hole, and the sealed hole is sealed to the deformation membrane to the contact of separation accommodation space and outside air. The deformation membrane is inserted at the straw piece of check out test set back along the crooked deformation of seam that meets an emergency to keep accommodation space airtight, reagent stability is good.

Drawings

The invention will be further described with reference to the following figures and examples:

fig. 1 is a schematic structural diagram of the reagent bottle of the present invention.

Fig. 2 is an explosion structure diagram of the reagent bottle of the present invention.

Fig. 3 is a schematic view of the rubber member mounting portion of the present invention in a partially cut-away enlarged structure.

Fig. 4 is the schematic cross-sectional structure diagram of the reagent bottle with the filter screen of the present invention.

Fig. 5 is a schematic sectional structure view of the rubber member of the present invention.

FIG. 6 is a schematic structural view showing the opened state of the beta 2-microglobulin assay kit of the present invention.

In the figure: a bottle body 10; a mounting hole 11; a first stepped hole 111; a second stepped bore 112; a step surface 113; a container body 12; a mounting portion 13; a clip portion 14; an air guide passage 15; a transparent portion 16; a rubber member 20; a sealing hole 21; a deformable film 22; the strain line slits 221; a guide portion 23; a bottle cap 30; a coating film 40; a screen 50; a packaging box 100; an annular wall 101; a bottom wall 102; a cover 103; the reagent bottle 200.

Detailed Description

The following description is only a preferred embodiment of the present invention, and does not limit the scope of the present invention.

Example, as shown in fig. 1 and 2, a β 2-microglobulin assay kit includes: comprising a packing box 100 and a reagent bottle 200 adapted to the packing box 100. The reagent bottle 200 includes a bottle body 10, a rubber member 20, and a bottle cap 30. The bottle body 10 includes a receiving space and a mounting hole 11 communicating with the receiving space. The vial 10 constitutes a container structure, and the accommodation space is for accommodating a reagent. The mounting hole 11 penetrates the wall of the bottle body 10 and communicates with the receiving space, and constitutes a passage for storing or discharging the reagent.

The rubber member 20 is made of a rubber material and comprises a sealing hole 21 and a deformation film 22 for closing the sealing hole 21 along the radial direction of the sealing hole 21, wherein the deformation film 22 comprises a strain seam 221 extending from the center to the hole wall direction of the sealing hole 21. The rubber member 20 is mounted to the mounting hole 11, and the sealing hole 21 communicates with the accommodating space.

The suction pipe of the detection device is inserted into the sealing hole 21, and the deformation membrane 22 is elastically deformed and tensioned on the peripheral wall of the suction pipe under the pushing action of the suction pipe. The strain slits 221 are radially distributed from the center to the periphery of the deformable membrane 22, so that the deformable membrane 22 is bent from the center to the periphery under the insertion of the straw. Wherein, straw spare and accommodation space intercommunication, the deformation membrane 22 of rubber spare 20 can elastic deformation under the squeezing action of straw spare to make rubber spare 20 closely laminate with the periphery wall of straw spare. Moreover, the deformation film 22 can extrude the peripheral wall of the suction pipe fitting, so that foreign matters brought by the suction pipe fitting are prevented from entering the reagent bottle, and the transmission path of a pollution source is reduced. Optionally, the deformable film 22 is located away from the opening where the mounting hole 11 intersects with the outer peripheral wall of the bottle body 10, so that the deformable film 22 approaches the accommodating space and the deformable film 22 bends toward the accommodating space. Optionally, the deformable membrane 22 is located at an end of the rubber member 20 to improve the ease of processing the deformable membrane 22. Alternatively, the deformable film 22 is located at the middle of the sealing hole 21 so that the deformable film 22 is bent to form a concave groove bent toward the receiving space.

The bottle cap 30 is detachably mounted on the bottle body 10 and closes the opening of the mounting hole 11 to further improve the sealing effect of the reagent bottle. The bottle cap 30 is fixed to the bottle body 10 by means of screw connection, snap connection, turn-buckle connection, or the like.

As shown in fig. 2 and 5, the rubber member 20 is positioned in the mounting hole 11 near an opening where the mounting hole 11 intersects with the outer sidewall of the bottle body 10, and the straw member is inserted into the rubber member 20 along the opening and into the receiving space. Optionally, the rubber member 20 includes a guide portion 23 disposed at an opening of the sealing hole 21, the guide portion 23 is inclined toward the opening of the mounting hole 11, and the guide portion 23 is an inclined surface or a curved surface. The guide part 23 is positioned at the opening of the sealing hole 21 to guide the straw piece to be inserted into the sealing hole 21 in the center, and the guide performance is good.

The rubber member 20 is mounted to the bottle body 10 to be confined in the bottle body 10. Alternatively, the rubber member 20 is screw-coupled to the bottle body 10; or, the peripheral wall of the rubber member 20 is connected with the hole wall of the mounting hole 11 of the bottle body 10 by cementing agent; or the rubber member 20 is connected with the hole wall of the mounting hole 11 in a tensioning manner; the rubber member 20 is defined in the hole wall of the mounting hole 11.

As shown in fig. 3, the mounting hole 11 includes a first stepped hole 111, a second stepped hole 112, a clamping portion 14 formed by partially protruding from a hole wall of the first stepped hole 111, and a stepped surface 113 located at an intersection of the first stepped hole 111 and the second stepped hole 112, a hole diameter of the first stepped hole 111 is larger than a hole diameter of the second stepped hole 112, and the rubber member 20 is mounted in the first stepped hole 111 and is defined between the clamping portion 14 and the stepped surface 113.

The catching portion 14 and the step surface 113 are oppositely spaced to form a groove structure defining the rubber member 20. Rubber component 20 is packed into the mounting groove and both ends are injectd between joint portion 14 and step face 113 to make rubber component 20 fix along the axial position of mounting hole 11, it is effectual to inject. The clamping portion 14 and the step surface 113 limit two ends of the rubber member 20, so that the rubber member 20 can keep a fixed position in the process of inserting and pulling the suction pipe member, and the installation is convenient and the strength is high. Optionally, the aperture of the second stepped hole 112 is larger than the aperture of the sealing hole 21 and larger than the minimum aperture of the clamping portion 14, so that the suction pipe member can be completely inserted into the sealing hole 21, and the rubber member 20 is elastically deformed towards the accommodating space and adsorbed on the suction pipe member, which has good sealing performance.

The clamping portion 14 is located at the opening of the mounting hole 11 and may be a cylindrical rib or an annular rib distributed at intervals. Optionally, the clamping portion 14 includes an annular rib, and the annular rib includes an inclined surface inclined toward the sealing hole 21 of the rubber member 20. The annular convex rib is provided with an inclined plane to guide the suction pipe piece to be inserted into the rubber piece 20, and the inserting accuracy is high. The clamping portion 14 is of a rigid structure so as to correct the insertion direction of the suction pipe fitting, and the centering performance is good. Alternatively, the slope of the snap-in portion 14 is less than or equal to the slope of the guide portion 23 to form a continuous guide structure.

As shown in fig. 2 and 3, the reagent bottle may further include a coating film 40 for closing the mounting hole 11, and the coating film 40 may cover an opening of the mounting hole 11 intersecting with the outer peripheral wall of the bottle body 10 to close the accommodating space. The coating film 40 covers an opening where the mounting hole 11 intersects to the outer peripheral wall of the vial body 10 to close the receiving space. The coating film 40 is made of a thin film material, and the coating film 40 seals the mounting hole 11 to keep the accommodating space in a closed state and prevent the reagent from being exposed to the air. And the coating film 40 is torn off or broken by external force or the straw piece is inserted, so that the straw piece can be inserted into the sealing hole 21 and connected with the rubber piece 20 in a sealing way. For example, the coating film 40 is an aluminum foil film, a PVC film, a PET film, or the like.

Alternatively, the bottle body 10 includes a container body 12 and a mounting portion 13 protruding from the container body 12 in a tubular shape, and the mounting hole 11 is formed in the mounting portion 13. The coating film 40 covers the end of the mounting part 13, and the bottle cap 30 is detachably connected with the mounting part 13. The rubber member 20 is fitted to the mounting portion 13, and the seal hole 21 communicates with the accommodating space in the container body 12. The coating film 40 covers the end of the mounting portion 13 to close the opening of the mounting hole 11, thereby facilitating packaging. The cap 30 is connected to the mounting portion 13 and abuts against the coating film 40, and is easy to open and close.

As shown in fig. 4, an elongated transparent portion 16 is provided on the outer peripheral wall of the container body 12, and the transparent portion 16 extends from the bottom of the container body 12 toward the mounting portion 13. The transparent part 16 facilitates the external observation of the volume and amount of the reagent. Optionally, the transparent portion 16 is provided with a scale for indicating the remaining amount and volume of the reagent for the convenience of the user.

The bottle body 10 includes an air guide passage 15 far from the mounting hole 11, and the reagent bottle includes a filter screen 50 mounted to the air guide passage 15. The air guide channel 15 can guide the air flow to keep the reagent in the bottle 10 flowing smoothly. The filter net 50 is used for filtering foreign matters in air, and improves the tidiness. It is worth mentioning that the reagent bottle can also be provided with no air guide channel 15, and the suction pipe can input air to change the pressure in the reagent bottle, so that the reagent can flow out, and the whole sealing performance is good. Optionally, the opening of the air guide channel 15 is closed by a rubber cover to prevent leakage.

As shown in fig. 6, the package 100 comprises an annular wall 101, a bottom wall 102 closed at one end of the annular wall 101, and a cover 103 movably connected to the annular wall 101, wherein the cover 103 rotates relative to the annular wall 101 to close or open another opening of the annular wall 101. The reagent bottle 200 is prevented from being accommodated in the packing box 100.

Claims

1. The beta 2-microglobulin determination kit is characterized by comprising a packaging box and a reagent bottle matched with the packaging box; the reagent bottle includes:

2. The β 2-microglobulin assay kit according to claim 1, wherein the deformable membrane is located away from an opening where the mounting hole intersects the outer peripheral wall of the bottle body.

3. The β 2-microglobulin assay kit according to claim 1, wherein the rubber member comprises a guide portion disposed at the opening of the sealing hole, the guide portion is inclined toward the opening of the mounting hole, and the guide portion is formed as an inclined surface or a curved surface.

4. The β 2-microglobulin assay kit according to claim 1, wherein the mounting hole comprises a first stepped hole, a second stepped hole, a clamping portion formed by partially protruding from a hole wall of the first stepped hole, and a stepped surface located at an intersection of the first stepped hole and the second stepped hole, wherein a hole diameter of the first stepped hole is larger than a hole diameter of the second stepped hole, and the rubber member is mounted in the first stepped hole and is defined between the clamping portion and the stepped surface.

5. The β 2-microglobulin assay kit according to claim 4, wherein the engaging portion comprises an annular rib, and the annular rib comprises a slope inclined toward the sealing hole of the rubber member.

6. The β 2-microglobulin assay kit of claim 4, wherein the pore size of the second stepped pore is larger than the pore size of the sealed pore.

7. The β 2-microglobulin assay kit according to claim 1, wherein the reagent bottle further comprises a cover film closing the mounting hole, the cover film covering an opening where the mounting hole intersects with the outer peripheral wall of the bottle body to close the accommodation space.

8. The beta 2-microglobulin assay kit according to claim 7, wherein the bottle body comprises a container body and a tubular mounting portion protruding from the container body, the mounting hole is formed in the mounting portion, the cover film covers an end portion of the mounting portion, and the bottle cap is detachably connected to the mounting portion.

9. The β 2-microglobulin assay kit according to claim 8, wherein an elongated transparent portion is provided on the outer peripheral wall of the container body, and the transparent portion extends from the bottom of the container body in the direction of the mounting portion.