CN212039115U - Full-automatic butt joint structure of tube tank system and chromatography system - Google Patents
Full-automatic butt joint structure of tube tank system and chromatography system Download PDFInfo
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- CN212039115U CN212039115U CN202020377481.9U CN202020377481U CN212039115U CN 212039115 U CN212039115 U CN 212039115U CN 202020377481 U CN202020377481 U CN 202020377481U CN 212039115 U CN212039115 U CN 212039115U
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Abstract
The utility model discloses a full-automatic butt joint structure of a tube tank system and a chromatography system, which comprises a tube tank system, a chromatography system, a CIP cleaning system and a control system; the tube tank system comprises a buffer solution main tube, a buffer solution branch tube, a buffer solution tank, a material pipeline, a material storage tank and an eluent collection tank; the CIP cleaning system is connected with one end of a buffer solution main pipe through a CIP pipeline, the buffer solution main pipe is provided with buffer solution branch pipes and is respectively connected with a buffer solution tank, and the bottom of the buffer solution tank is connected to the CIP cleaning system through a pipeline; the left side of the chromatography system is provided with a buffer solution inlet and a material inlet, and the right side is provided with a material outlet; the buffer liquid main pipe is connected with a buffer liquid inlet, and the material inlet is connected with a material storage tank; the material outlet is connected with the eluent collecting tank through a material pipeline. The utility model discloses realize the automatic butt joint of pipe jar system and chromatography system, need not the manual switching hose of operating personnel.
Description
Technical Field
The utility model relates to a butt-joint structural of chromatography system and tube tank system especially relates to a full-automatic butt-joint structural of tube tank system and chromatography system.
Background
Chromatography systems are the primary purification equipment in biopharmaceutical downstream purification processes. The tube tank system is a system module formed by combining components such as tanks, pipelines, instruments and the like, and is a general name of pipelines and tank bodies for connecting all main purification equipment. The parts of the pipe tank system, such as pipelines, instruments, valves and the like which are connected with the chromatography system, can belong to the chromatography system and also can belong to the pipe tank system. The main technical process of the pipe tank system comprises the following steps: production process, CIP process and SIP process. The chromatographic system mainly comprises the following processes: balancing, loading, washing, eluting, regenerating, disinfecting, storing and the like. The buffer solution and the material used in each process of the chromatography system are all provided by a tube tank system. At present, the two butt joints can not realize the full-automatic control of all the technological processes by an automatic control system, but manually disassemble and connect pipelines, and after the pipelines are switched, buffer solution or materials in a tube tank system are supplied to a chromatography system by starting an automatic program. In the production process, the connection mode of pipelines (generally, a section of hose is used for convenience of disassembly) at the inlet and the outlet of the chromatography system needs to be changed for many times, and after the pipelines are connected each time, the corresponding steps are started through an automatic control system. However, manual disassembly and assembly and switching of the pipelines increase manual operation, and increase the risks of misoperation and leakage. The existing pharmaceutical technology increasingly looks at automatic production and recording, and needs to reduce manual operation as much as possible.
At present, the pipeline that the tube tank system is connected with the chromatography system needs dismouting many times, has increased the risk of revealing of pharmaceutical production, and the maloperation of human factor can be brought in the manual operation, can not form the production record automatically.
The chromatography system is a single-machine device, the process steps are complex, different media need to be provided by the tube tank system in different operation steps, each step of the chromatography process is a continuous production process, at present, one step is finished, the chromatography system needs to be suspended, and after connection switching between an inlet pipeline and an outlet pipeline of the chromatography system and the tube tank system is finished, the next step can be started, so that the production efficiency of the chromatography system is greatly reduced, and the production quality of medicines is also reduced. The recorded curves will produce ghost peaks due to the pause of the chromatography system.
A large amount of air exists in the pipeline from the tube tank system to the chromatography system, and before the pipeline conveys corresponding media, the chromatography system can only exhaust bubbles in the pipeline by the aid of the pipeline, and the pipeline can not be used until the bubbles are completely exhausted, so that exhaust load of the chromatography system is increased.
Many times artificial dismouting pipeline can lead to the interface not hard up, takes place the medicine and reveals, causes very big production accident. Leakage needs to be avoided as far as possible in the drug production process, the existing butt joint scheme needs to be disassembled and assembled for many times, and the sealing performance of a butt joint pipeline cannot be guaranteed.
The requirements of drug production regulations are more and more strict, exposure to a production environment is reduced as far as possible in the drug production process, and the current docking scheme inevitably needs to be disassembled for many times and exposed to the environment for many times, so that the risk of drug cross-contamination is increased.
Therefore, developing a full-automatic docking structure of the tube-tank system and the chromatography system becomes a problem to be solved by those skilled in the art.
SUMMERY OF THE UTILITY MODEL
The utility model provides a solve above-mentioned not enough, provide a full-automatic butt joint structure of pipe jar system and chromatography system.
The above object of the present invention is achieved by the following technical solutions: a full-automatic butt joint structure of a tube tank system and a chromatography system comprises the tube tank system, the chromatography system, a CIP cleaning system and a control system;
the tube tank system comprises a buffer solution main tube, a buffer solution branch tube, a buffer solution tank, a material pipeline and a material storage tank; the CIP cleaning system is connected with one end of a buffer solution main pipe through a CIP pipeline, the buffer solution main pipe is provided with a plurality of buffer solution branch pipes and is respectively connected with a buffer solution tank, and the bottom of the buffer solution tank is connected to the CIP cleaning system through a pipeline;
the left side of the chromatography system is provided with a buffer solution inlet and a material inlet, and the right side of the chromatography system is provided with a material outlet;
the buffer solution main pipe is connected with a buffer solution inlet, and the material inlet is connected with a material storage tank through a material pipeline; the material outlet is connected with an eluent collecting tank through a material pipeline;
and each buffer solution branch pipe and the space between each pipeline connecting points are respectively provided with a pneumatic diaphragm valve, each pneumatic diaphragm valve is respectively connected with a corresponding electromagnetic valve, and the electromagnetic valves are connected with a control system.
Furthermore, a first discharge point is arranged at the lowest point of the buffer liquid main pipe, a first discharge pneumatic diaphragm valve is arranged, material pipelines on one sides of the buffer liquid inlet and the material inlet are connected to a material pipeline on one side of the material outlet through a cross-over pipeline which bypasses the chromatography system, a second discharge point is connected to the lowest point of the cross-over pipeline, and a second discharge pneumatic diaphragm valve is arranged; the first discharge pneumatic diaphragm valve and the second discharge pneumatic diaphragm valve are respectively connected with a first discharge solenoid valve and a second discharge solenoid valve, and the first discharge solenoid valve and the second discharge solenoid valve are both connected with a control system; the eluent collection tank is connected to the CIP cleaning system, and the material storage tank is connected to the CIP cleaning system in a backflow mode.
Further, 11 buffer solution branch pipes are provided, and correspondingly, the number of the buffer solution tanks is 11, namely a first buffer solution tank, a second buffer solution tank, a third buffer solution tank, a fourth buffer solution tank, a fifth buffer solution tank, a sixth buffer solution tank, a seventh buffer solution tank, an eighth buffer solution tank, a ninth buffer solution tank, a tenth buffer solution tank and an eleventh buffer solution tank.
The utility model discloses a theory of operation:
when the chromatography system is balanced, the balance liquid is supplied to the chromatography system by a balance liquid storage tank (a first buffer liquid tank) of the tube tank system through a buffer liquid branch pipe and a buffer liquid main pipe.
When the chromatography system samples, the material storage tank of the tube tank system provides materials to the chromatography system through the material pipeline.
When the chromatography system is used for impurity washing, an impurity washing liquid storage tank (a second buffer liquid tank) of the tube tank system supplies impurity washing liquid to the chromatography system through a buffer liquid branch pipe and a buffer liquid main pipe.
When the chromatography system is used for elution, an eluent storage tank (a third buffer tank) of the tube tank system provides eluent to the chromatography system through the buffer branch tube and the buffer main tube, and meanwhile, a material outlet of the chromatography system collects the eluent to the eluent collection tank through the material pipeline.
When the chromatography system is regenerated, a regenerated liquid is supplied to the chromatography system from a regenerated liquid storage tank (a fourth buffer liquid tank) of the tube tank system through the buffer liquid branch pipe and the buffer liquid main pipe.
When the chromatography system is disinfected, a disinfectant storage tank (a fifth buffer tank) of the tube tank system supplies disinfectant to the chromatography system through the buffer branch pipe and the buffer main pipe.
When the chromatography system column is stored, a storage solution is supplied to the chromatography system from a storage solution storage tank (sixth buffer solution tank) of the tube tank system through the buffer solution branch pipe and the buffer solution main pipe.
When the chromatography system is washed with water, WFI is supplied from a WFI storage tank (a seventh buffer tank) of the tube tank system to the chromatography system through a buffer branch tube and a buffer main tube. The material outlet of the chromatography system is switched to flow back through an outlet valve group consisting of pneumatic diaphragm valves and is discharged from a second discharge point.
When the chromatography system is cleaned, an alkali liquor storage tank (an eighth buffer liquor tank) of the tube tank system supplies alkali liquor to the chromatography system through the buffer liquor branch pipe and the buffer liquor main pipe. The material outlet of the chromatography system is discharged from a second discharge point of the chromatography system after the flow is switched through an outlet valve group consisting of pneumatic diaphragm valves.
And the ninth buffer solution tank, the tenth buffer solution tank and the eleventh buffer solution tank are used for connecting other buffer solutions used for the transport chromatography system.
When the buffer liquid main pipe of the pipe tank system enters CIP for cleaning, the CIP cleaning system provides cleaning liquid to the butt joint port through the CIP pipeline, provides the cleaning liquid to each buffer liquid branch pipe through the buffer liquid main pipe, reversely flows to the tank bottom of the corresponding buffer liquid tank and then flows to the CIP cleaning system.
When the material pipeline needs to be cleaned, cleaning liquid of the CIP cleaning system enters the material pipeline on one side of the material outlet through the top of the eluent collection tank, then enters the material pipeline on one side of the material inlet through the cross-over pipeline, finally enters the material storage tank, and flows back to the CIP cleaning system from the tank bottom. The CIP cleaning system referred to here may be the CIP cleaning system of the present invention, or may be another external CIP cleaning system.
The utility model has the advantages of:
1. the cross cleaning of the interface valve and the pipeline is realized in the self cleaning process of the tube tank system and the chromatography system. The cleaning interface has no dead angle, so that the pipeline does not need to be disassembled.
2. The automatic medium conveying of the tube tank system and the chromatography system is realized by the signal communication of the automatic control systems of the two parties. Can realize a chromatographic curve without ghost peaks.
3. The interface is provided with a low-point discharge branch, so that the buffer solution can be exhausted before being conveyed to the chromatography system, and the chromatography system can be prevented from alarming due to excessive bubbles.
4. Automatic butt joint does not need an operator to manually switch hoses, the pipelines are fixed after being connected, and automatic control of all process steps is realized through a control system. Prevent the bad risk that manual operation brought for drug manufacturing, reduce operating personnel's work load simultaneously. The full-automatic butt joint of the tube tank system and the chromatography system is realized, and the butt joint port can be cleaned in a cross way, so that the aim of thorough cleaning is fulfilled.
5. Many times artificial dismouting pipeline can lead to the interface not hard up, takes place the medicine and reveals, causes very big production accident. Leakage needs to be avoided as far as possible in the drug production process, the existing butt joint scheme needs to be disassembled and assembled for many times, and the sealing performance of a butt joint pipeline cannot be guaranteed.
Compared with the prior art, the utility model the advantage be: the utility model discloses can realize the automatic butt joint of pipe jar system and chromatography system, do not need operating personnel manual switching hose, the pipe connection just is fixed after good, but realizes the automated control of full technology step through control system. Prevent the bad risk that manual operation brought for drug manufacturing, reduce operating personnel's work load simultaneously. Meanwhile, the butt joint can be cleaned in a crossed manner, so that the aim of thorough cleaning is fulfilled.
Drawings
Fig. 1 is a schematic structural diagram of the present invention.
Detailed Description
The present invention will be described in detail with reference to the accompanying drawings.
As shown in fig. 1, a full-automatic docking structure of a tube tank system and a chromatography system comprises a tube tank system 1, a chromatography system 2, a CIP cleaning system 3 and a control system 4;
the tube tank system 1 comprises a buffer solution main tube 1-1, a buffer solution branch tube 1-2, a buffer solution tank 1-3, a material pipeline 1-6, a material storage tank 1-4 and an eluent collection tank 1-5; the CIP cleaning system 3 is connected with one end of a buffer solution main pipe 1-1 through a CIP pipeline 3-1, the buffer solution main pipe 1-1 is provided with a plurality of buffer solution branch pipes 1-2 and is respectively connected with a buffer solution tank 1-3, and the bottom of the buffer solution tank 1-3 is connected to the CIP cleaning system 3 through a pipeline;
the left side of the chromatography system 2 is provided with a buffer solution inlet 2-1 and a material inlet 2-2, and the right side of the chromatography system 2 is provided with a material outlet 2-3;
the buffer solution main pipe 1-1 is connected with a buffer solution inlet 2-1, and the material inlet 2-2 is connected with a material storage tank 1-4 through a material pipeline; the material outlet 2-3 is connected with an eluent collecting tank 1-5 through a material pipeline;
and a pneumatic diaphragm valve 6 is arranged on each buffer branch pipe 1-2 and between each pipeline connecting point 5, each pneumatic diaphragm valve 6 is respectively connected with a corresponding solenoid valve (not shown), and the solenoid valves (not shown) are connected with the control system 4.
Further, a first discharge point 7 is arranged at the lowest point of the buffer solution main pipe 1-1, a first discharge pneumatic diaphragm valve 8 is arranged, the material pipelines 1-6 on one sides of the buffer solution inlet 2-1 and the material inlet 2-2 are connected to the material pipelines 1-6 on one sides of the material outlet 2-3 through a cross-over pipeline 1-7 bypassing the chromatography system 2, and a second discharge point 9 is connected to the lowest point of the cross-over pipeline 1-7 and a second discharge pneumatic diaphragm valve 10 is arranged; the first discharge pneumatic diaphragm valve 8 and the second discharge pneumatic diaphragm valve 10 are respectively connected with a first discharge solenoid valve (not shown) and a second discharge solenoid valve (not shown), and the first discharge solenoid valve and the second discharge solenoid valve are both connected with the control system 4; the eluent collection tanks 1-5 are connected to the CIP cleaning system 3, and the material storage tanks 1-4 are connected to the CIP cleaning system 3 in a backflow mode.
Further, 11 buffer solution branch pipes 1-2 are provided, and correspondingly, 11 buffer solution tanks 1-3 are provided, which are respectively a first buffer solution tank, a second buffer solution tank, a third buffer solution tank, a fourth buffer solution tank, a fifth buffer solution tank, a sixth buffer solution tank, a seventh buffer solution tank, an eighth buffer solution tank, a ninth buffer solution tank, a tenth buffer solution tank and an eleventh buffer solution tank.
The utility model discloses a theory of operation:
when the chromatography system 2 is equilibrated, an equilibration solution is supplied from an equilibration solution storage tank (a first buffer solution tank 1-3) of the tube tank system 1 to the chromatography system 2 through the buffer solution branch tube 1-2 and the buffer solution main tube 1-1.
When the chromatography system 2 is used for sampling, materials are provided to the chromatography system 2 through the material pipelines by the material storage tanks 1-4 of the tube tank system 1.
When the chromatography system 2 is used for impurity washing, an impurity washing liquid is supplied to the chromatography system 2 from an impurity washing liquid storage tank (a second buffer liquid tank 1-3) of the tube tank system 1 through the buffer liquid branch pipe 1-2 and the buffer liquid main pipe 1-1.
When the chromatographic system 2 is used for elution, an eluent storage tank (a third buffer solution tank 1-3) of the tube tank system 1 provides eluent to the chromatographic system 2 through the buffer solution branch tube 1-2 and the buffer solution main tube 1-1, and meanwhile, a material outlet 2-3 of the chromatographic system 2 collects the eluent to an eluent collection tank 1-5 through a material pipeline.
When the chromatography system 2 is regenerated, a regeneration liquid is supplied from a regeneration liquid storage tank (a fourth buffer liquid tank 1-3) of the tube tank system 1 to the chromatography system 2 through the buffer liquid branch tube 1-2 and the buffer liquid main tube 1-1.
When the chromatographic system 2 is disinfected, a disinfectant is supplied to the chromatographic system 2 from a disinfectant storage tank (a fifth buffer tank 1-3) of the tube tank system 1 through the buffer branch tube 1-2 and the buffer main tube 1-1.
When the column of the chromatography system 2 is stored, a storage solution is supplied from a storage solution tank (sixth buffer solution tank 1-3) of the tube tank system 1 to the chromatography system 2 through the buffer solution branch tube 1-2 and the buffer solution main tube 1-1.
When the chromatography system 2 is washed with water, WFI is supplied from a WFI storage tank (a seventh buffer tank 1-3) of the tube tank system 1 to the chromatography system 2 via the buffer branch tube 1-2 and the buffer main tube 1-1. The material outlet 2-3 of the chromatography system 2 is switched back through an outlet valve group consisting of several pneumatic diaphragm valves 6 and discharged from a second discharge point 9.
When the chromatography system 2 is cleaned, an alkali liquor storage tank (an eighth buffer liquor tank 1-3) of the tube tank system 1 supplies alkali liquor to the chromatography system 2 through the buffer liquor branch pipe 1-2 and the buffer liquor main pipe 1-1. The material outlet 2-3 of the chromatography system 2 is switched back by an outlet valve group consisting of a plurality of pneumatic diaphragm valves 6 and discharged by a second discharge point 9 of the chromatography system 2.
The ninth buffer solution tank 1-3, the tenth buffer solution tank 1-3 and the eleventh buffer solution tank 1-3 are used for connecting other buffers used by the transport chromatography system 2.
When the buffer solution main pipe 1-1 of the pipe tank system 1 enters CIP for cleaning, the CIP cleaning system provides cleaning liquid to the butt joint port through the CIP pipeline 3-1, provides the cleaning liquid to each buffer solution branch pipe 1-2 through the buffer solution main pipe 1-1, reversely flows to the tank bottom of the corresponding buffer solution tank 1-3 and then flows to the CIP cleaning system 3.
When the material pipeline needs to be cleaned, cleaning liquid of the CIP cleaning system enters the material pipeline 1-6 at one side of the material outlet 2-3 through the top of the eluent collecting tank 1-5, then enters the material pipeline 1-6 at one side of the material inlet 2-2 through the cross-over pipeline 1-7, finally enters the material storage tank 1-4, and flows back to the CIP cleaning system from the tank bottom. The CIP cleaning system referred to here may be the CIP cleaning system 3 of the present invention, or may be another external CIP cleaning system.
The above only is the embodiment of the present invention, not limiting the patent scope of the present invention, all the equivalent structures or equivalent processes that are used in the specification and the attached drawings or directly or indirectly applied to other related technical fields are included in the patent protection scope of the present invention.
Claims (4)
1. The utility model provides a full-automatic butt joint structure of tube jar system and chromatography system which characterized in that: comprises a pipe tank system, a chromatography system, a CIP cleaning system and a control system;
the tube tank system comprises a buffer solution main tube, a buffer solution branch tube, a buffer solution tank, a material pipeline, a material storage tank and an eluent collection tank; the CIP cleaning system is connected with one end of a buffer solution main pipe through a CIP pipeline, the buffer solution main pipe is provided with a plurality of buffer solution branch pipes and is respectively connected with a buffer solution tank, and the bottom of the buffer solution tank is connected to the CIP cleaning system through a pipeline;
the left side of the chromatography system is provided with a buffer solution inlet and a material inlet, and the right side of the chromatography system is provided with a material outlet;
the buffer solution main pipe is connected with a buffer solution inlet, and the material inlet is connected with a material storage tank through a material pipeline; the material outlet is connected with an eluent collecting tank through a material pipeline;
and each buffer solution branch pipe and the space between each pipeline connecting points are respectively provided with a pneumatic diaphragm valve, each pneumatic diaphragm valve is respectively connected with a corresponding electromagnetic valve, and the electromagnetic valves are connected with a control system.
2. The full-automatic butt joint structure of the tube tank system and the chromatography system as claimed in claim 1, wherein: the lowest point of the buffer liquid main pipe is provided with a first discharge point and a first discharge pneumatic diaphragm valve, and pipelines at one side of the buffer liquid inlet, the material inlet and the material outlet are provided with second discharge points and second discharge pneumatic diaphragm valves; the first discharge pneumatic diaphragm valve and the second discharge pneumatic diaphragm valve are respectively connected with the first discharge solenoid valve and the second discharge solenoid valve, and the first discharge solenoid valve and the second discharge solenoid valve are both connected with the control system.
3. The full-automatic butt joint structure of the tube tank system and the chromatography system as claimed in claim 1, wherein: the buffer solution branch pipes are 11, and correspondingly, the number of the buffer solution tanks is 11, namely a first buffer solution tank, a second buffer solution tank, a third buffer solution tank, a fourth buffer solution tank, a fifth buffer solution tank, a sixth buffer solution tank, a seventh buffer solution tank, an eighth buffer solution tank, a ninth buffer solution tank, a tenth buffer solution tank and an eleventh buffer solution tank.
4. The full-automatic butt joint structure of the tube tank system and the chromatography system as claimed in claim 1, wherein: the buffer solution inlet and the material inlet are connected with the material outlet through pipelines.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202020377481.9U CN212039115U (en) | 2020-03-23 | 2020-03-23 | Full-automatic butt joint structure of tube tank system and chromatography system |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202020377481.9U CN212039115U (en) | 2020-03-23 | 2020-03-23 | Full-automatic butt joint structure of tube tank system and chromatography system |
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| Publication Number | Publication Date |
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| CN212039115U true CN212039115U (en) | 2020-12-01 |
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|---|---|---|---|
| CN202020377481.9U Active CN212039115U (en) | 2020-03-23 | 2020-03-23 | Full-automatic butt joint structure of tube tank system and chromatography system |
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| Country | Link |
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| CN (1) | CN212039115U (en) |
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- 2020-03-23 CN CN202020377481.9U patent/CN212039115U/en active Active
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Denomination of utility model: A fully automatic docking structure between pipe tank system and chromatography system Effective date of registration: 20211222 Granted publication date: 20201201 Pledgee: Industrial and Commercial Bank of China Limited Shanghai Minhang sub branch Pledgor: ANJIYI INDUSTRIAL (SHANGHAI) CO.,LTD. Registration number: Y2021310000152 |