CN211798967U - Solid phase extraction eluent collection device - Google Patents
Solid phase extraction eluent collection device Download PDFInfo
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- CN211798967U CN211798967U CN202020349606.7U CN202020349606U CN211798967U CN 211798967 U CN211798967 U CN 211798967U CN 202020349606 U CN202020349606 U CN 202020349606U CN 211798967 U CN211798967 U CN 211798967U
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Abstract
The solid phase extraction eluent collecting device is characterized by comprising a solid phase extraction column fixing frame and an eluent collecting pipe fixing frame. The solid phase extraction column fixing frame consists of a first upper plate, a first middle plate, a first side vertical frame and a base frame, and the first upper plate and the first middle plate are provided with position holes for placing the solid phase extraction column; the eluent collecting pipe fixing frame is composed of a second upper layer plate, a second middle layer plate, a second side vertical frame and a base panel, and collecting pipe position holes are formed in the second upper layer plate and the second middle layer plate. The utility model has the advantages that: the whole set of device simple structure, reasonable in design, it is convenient to use, can realize elution simultaneously of bulk sample, and whole set of device low cost can promote the nature by force.
Description
Technical Field
The utility model belongs to the technical field of the detection and analysis, concretely relates to solid-phase extract collection device.
Background
Solid Phase Extraction (SPE) is a sample pretreatment technology based on the liquid-Solid Phase chromatography theory, and the principle is to selectively adsorb a target object in a liquid sample by using a Solid adsorbent to separate the target object from a matrix and an interfering substance of the sample, and then elute or heat-desorb the target object by using an eluent to separate and enrich the target compound. The technology greatly enhances the detection capability of analytes, particularly trace analytes, and improves the recovery rate of the detected samples. At present, the solid phase extraction technology has been widely applied to the fields of food, medicine, environment and the like, and mainly aims at the separation and enrichment of trace or trace target compounds in complex samples.
However, the existing solid phase extraction technology has the following problems:
the commercialized solid phase extraction device is mainly made of glass materials, and has heavy volume, fragility and higher price, thereby influencing the application range of the device.
Most of the existing solid phase extraction devices are matched with a vacuum pump for air suction and pressure reduction, the majority of cases continue to operate by utilizing the gravity action of liquid in actual operation, and the elution effect is better due to slow flow rate of normal-pressure elution. Therefore, the prior device has certain function waste.
The fixing support and the connecting pipeline of the conventional solid phase extraction device have cross contamination, the fixing support and the connecting pipeline thereof need to be cleaned and replaced periodically in each use, the steps are repeated, the operation is complex, and the use cost is high.
Current solid phase extraction device need install the test-tube rack in the solid phase extraction device earlier at the elution in-process, puts and collects the test tube, then covers the lid, will guarantee simultaneously that the solvent guide needle below the lid corresponds every test tube in proper order, then puts the solid phase extraction post in proper order, then elutes, and the back is accomplished in the elution, still will take out the test tube once more, puts dedicated test-tube rack again, extracts the solid phase extraction post in proper order at last. The elution operation steps are complicated, and particularly, the preparation work and the post-treatment time are too long, so that the time for elution is really short.
The maximum elution number of the existing solid phase extraction device is 24 holes, simultaneous elution cannot be realized for a large number of samples, and the use efficiency is not high.
The supporting mount space of current solid phase extraction device is less, and the mount is also unstable simultaneously, puts the in-process of taking the collecting pipe and probably smashes, has unsafe factor.
SUMMERY OF THE UTILITY MODEL
An object of the utility model is to solve the above-mentioned problem and provide a low cost, simple structure, the solid phase extraction eluant collection device of simple operation can satisfy a plurality of solid phase extraction posts and elute simultaneously to greatly improve work efficiency, shortened check-out time.
In order to achieve the purpose, the utility model adopts the following technical proposal:
a solid phase extraction eluent collection device comprises a solid phase extraction column fixing frame and an eluent collection pipe fixing frame, wherein the solid phase extraction column fixing frame can be detachably fixed at the top of the eluent collection pipe fixing frame;
the solid-phase extraction column fixing frame comprises a first upper plate, a first middle plate, a first side vertical frame and a base frame, the first upper plate is horizontally fixed at the top end of the first side vertical frame, the base frame is horizontally fixed at the bottom end of the first side vertical frame, the first middle plate is horizontally fixed on the first side vertical frame and is close to the first upper plate, and the first upper plate and the first middle plate of the solid-phase extraction column fixing frame are provided with solid-phase extraction column position holes for placing a solid-phase extraction column;
the eluent collecting pipe fixing frame comprises a second upper plate, a second middle plate, a second side vertical frame and a base panel, the second upper plate is horizontally fixed at the top end of the second side vertical frame, the base panel is horizontally fixed at the bottom end of the second side vertical frame, the second middle plate is horizontally fixed on the second side vertical frame and is close to the second upper plate, and the second upper plate and the second middle plate of the eluent collecting pipe fixing frame are provided with eluent collecting pipe position holes for placing an eluent collecting pipe.
In some embodiments, a frame slot is provided on the second upper plate of the eluent collection tube holder, and the base frame of the solid-phase extraction column holder can be fixed in the frame slot.
In some embodiments, an eluate collection tube card slot is provided on a base panel of the eluate collection tube holder.
In some embodiments, the solid phase extraction column site well, the eluent collection tube site well, and the eluent collection tube card slot are located on the same axis.
In some embodiments, the solid phase extraction column holder location hole on the first upper plate of the solid phase extraction column holder is capable of retaining an upper end handle of a solid phase extraction column.
In some embodiments, a hollow design is adopted between the first middle plate and the base frame of the solid phase extraction column fixing frame.
In some embodiments, the base frame of the solid phase extraction column holder is comprised of four rims.
In some embodiments, the upper end of the eluate collection tube is higher than the second upper plate of the eluate collection tube holder.
In some embodiments, the lower end of the solid phase extraction column is disposed within a tube orifice of the eluent collection tube.
In some embodiments, the number of solid phase extraction column site pores and the eluent collection site pores is from 1 to 100, preferably from 30 to 90.
In some embodiments, the solid phase extraction column holder and the eluent collection tube holder are made of plastic or metal.
Known through above technical scheme, compare with prior art, the utility model discloses a solid-phase extraction eluant collection device's advantage lies in:
1. the whole device is simple in structure, reasonable in design and convenient to assemble, move and disassemble.
2. The device can realize the simultaneous operation of multiple samples and can simultaneously elute a plurality of solid-phase extraction columns at one time.
3. The hollow-out design of the solid-phase extraction column fixing frame is convenient for observing the elution condition of the solid-phase extraction column eluent, the operation is simple, convenient and quick, the design mode is disassembled after the elution is completed, the single extraction and transfer mode is omitted, the operation is completed at one time, and the work efficiency is improved.
4. The connecting device is omitted between the solid phase extraction column and the eluent collecting tube, so that cross contamination is avoided.
5. The elution process can be conveniently moved, and the stability of the elution process is ensured by special design.
6. The device has low cost and strong popularization.
Drawings
The drawings are only intended to illustrate and explain the present invention and do not limit the scope of the invention. Wherein:
fig. 1 is a schematic view of the whole three-dimensional structure of the solid-phase extraction eluent collecting device of the utility model.
Fig. 2 is a schematic view of the cross-sectional structure of the solid-phase extraction eluent collecting device of the present invention.
Fig. 3 is a schematic view of the solid-phase extraction column fixing frame of the present invention.
Fig. 4 is a schematic view of the three-dimensional structure of the fixing frame of the eluent collecting tube of the present invention.
Description of reference numerals:
1-a first upper plate; 2-a first medium layer plate; 3-a base frame; 4-a second upper plate; 5-a second middle layer plate; 6-second side vertical frame; 7-a base panel; 8-solid phase extraction column position hole; 9-a first side upright frame; 10-a frame card slot; 11-eluent collection tube neck; 12-collecting the header well with the eluent; 13-hollowed out position; 14-solid phase extraction column; 15-eluent collection tube.
Detailed Description
In order to make the objects, technical solutions and advantages of the present invention more apparent, the present invention will be described in detail with reference to the accompanying drawings.
In the description of the present invention, reference to "one embodiment" means that a specific feature, structure, or parameter, step, or the like described in the embodiment is included in at least one embodiment according to the present invention. Thus, the use of terms such as "in one embodiment," "in one embodiment," and the like, in the description of the invention is not intended to refer specifically to the same embodiment, nor is the use of terms such as "in another embodiment," "in a different embodiment of the invention," "in another embodiment of the invention," and the like, in the description of the invention intended to refer specifically to features that are included in a particular different embodiment. Those of skill in the art will understand that the particular features, structures or parameters, steps, etc., disclosed in one or more embodiments of the present disclosure may be combined in any suitable manner.
In the description of the present invention, the terms "upper", "lower", "inner", "outer", etc. indicate orientations or positional relationships based on the orientations or positional relationships shown in the drawings, and are only for convenience of description and simplified description, but do not indicate or imply that the device or element referred to must have a specific orientation, be constructed and operated in a specific orientation, and thus, should not be construed as limiting the present invention.
In the description of the present invention, it is to be noted that, unless otherwise explicitly specified or limited, the terms "connected" and "connected" are to be interpreted broadly, and may be, for example, fixedly connected, detachably connected, or integrally connected; may be directly connected or indirectly connected through an intermediate. The specific meaning of the above terms in the present invention can be understood as appropriate by those of ordinary skill in the art.
As shown in fig. 1-4, the solid phase extraction eluent collecting device of the utility model comprises a solid phase extraction column fixing frame and an eluent collecting pipe fixing frame, wherein the solid phase extraction column fixing frame can be detachably fixed at the top of the eluent collecting pipe fixing frame.
Solid-phase extraction column mount include first top plate 1, first intermediate lamella 2, first side grudging post 9 and base frame 3, the top at first side grudging post 9 is fixed to 1 level of first top plate, the bottom at first side grudging post 9 is fixed to 3 levels of base frame, 2 levels of first intermediate lamella are fixed on first side grudging post 9 and are close to first top plate 1, first top plate 1 and first intermediate lamella 2 of solid-phase extraction column mount are equipped with solid-phase extraction column position hole 8 for place solid-phase extraction column 14, first intermediate lamella 2 has the fixed action to solid-phase extraction column mount, can also fix the position of solid-phase extraction column 14 simultaneously.
Eluent collecting pipe mount include second upper plate 4, second intermediate lamella board 5, second side grudging post 6 and base panel 7, the top at second side grudging post 6 is fixed to 4 levels of second upper plate, the bottom at second side grudging post 6 is fixed to 7 levels of base panel, 5 levels of second intermediate lamella board are fixed on second side grudging post 6 and are close to second upper plate 4, second upper plate 4 and the second intermediate lamella board 5 of eluent collecting pipe mount are equipped with eluent collecting pipe position hole 12 for place eluent collecting pipe 15, 5 fixed actions to taking off liquid collecting pipe mount of second intermediate lamella board, simultaneously can also fix the position of eluent collecting pipe 15.
A frame clamping groove 10 is formed in the second upper layer plate 4 of the eluent collecting pipe fixing frame, and the base frame 3 of the solid-phase extraction column fixing frame and the frame clamping groove 10 are matched with each other, so that the base frame 3 of the solid-phase extraction column fixing frame can be fixed in the frame clamping groove 10; an eluent collecting pipe clamping groove 11 is arranged on the base panel 7 and used for positioning an eluent collecting pipe 15.
The solid phase extraction column fixing frame position hole 8 on the first upper plate 1 of the solid phase extraction column fixing frame can clamp the upper end handle of the solid phase extraction column 14.
The hollow design is adopted between the first middle layer plate 2 and the base frame 3 of the solid phase extraction column fixing frame, so that the flowing condition of the elution liquid is conveniently observed.
The base frame 3 of the solid phase extraction column fixing frame only has four frames without a middle panel and a position hole, and is beneficial to the disassembly and the combination of an upper part and a lower part.
The upper end of the eluent collecting pipe 15 can be higher than the second upper layer plate 4 of the eluent collecting pipe fixing frame, namely, the upper end is positioned between the second upper layer plate 4 of the eluent collecting pipe fixing frame and the first middle layer plate 2 of the solid-phase extraction column fixing frame, and the lower end of the eluent collecting pipe 15 is positioned on the eluent collecting pipe clamping groove 11.
The solid phase extraction column position hole 8, the eluent collecting pipe position hole 12 and the eluent collecting pipe clamping groove 11 are positioned on the same axis, and the size and the shape of the position hole can be properly adjusted according to the size of the solid phase extraction column and the eluent collecting pipe. The lower end of the solid phase extraction column 14 is placed in the orifice of the eluent collection tube 15, but not in contact with each other.
The number of the solid phase extraction column site holes 8 and the eluent collection site holes 12 may be arbitrarily set according to actual needs, and may be, for example, 1 to 100, preferably 30, 40, 50, 60, 70, 80, 90, or the like.
In one embodiment, the solid phase extraction column holder and the eluent collection tube holder are all made of plastic, such as polyethylene, polypropylene, polybutylene, polyvinyl chloride, etc. In another embodiment, the solid phase extraction column holder and the eluent collection tube holder can be made of metal, such as stainless steel, aluminum alloy, etc.
In one embodiment, the solid phase extraction eluent collecting device of the utility model is used for determining ofloxacin in milk, and the use process is as follows:
and opening the clamping groove, taking down the eluent collecting pipe fixing frame, sequentially placing a plurality of eluent collecting pipes, fixing the solid-phase extraction column fixing frame on the eluent collecting pipe fixing frame, placing the 500mg and 6mL solid-phase extraction column on the solid-phase extraction column fixing frame, and waiting for elution operation.
According to the regulation of the standard GB/T21312-2007, 25 raw milk sample eluents are collected and measured by using the solid phase extraction eluent collection device, and the specific measurement results are as follows:
TABLE 1 determination of ofloxacin in milk
The utility model discloses a solid-phase extraction eluant collection device simple structure, reasonable in design, it is convenient to use, can realize that wholesale sample elutes simultaneously, and complete equipment low cost can promote the nature by force.
The above-mentioned embodiments, further detailed description of the objects, technical solutions and advantages of the present invention, it should be understood that the above-mentioned embodiments are only specific embodiments of the present invention, and are not intended to limit the present invention, and any modifications, equivalent substitutions, improvements, etc. made within the spirit and principle of the present invention should be included in the scope of the present invention.
Claims (10)
1. The solid-phase extraction eluent collecting device is characterized by comprising a solid-phase extraction column fixing frame and an eluent collecting pipe fixing frame, wherein the solid-phase extraction column fixing frame can be detachably fixed at the top of the eluent collecting pipe fixing frame;
the solid-phase extraction column fixing frame comprises a first upper plate, a first middle plate, a first side vertical frame and a base frame, the first upper plate is horizontally fixed at the top end of the first side vertical frame, the base frame is horizontally fixed at the bottom end of the first side vertical frame, the first middle plate is horizontally fixed on the first side vertical frame and is close to the first upper plate, and the first upper plate and the first middle plate of the solid-phase extraction column fixing frame are provided with solid-phase extraction column position holes for placing a solid-phase extraction column;
the eluent collecting pipe fixing frame comprises a second upper plate, a second middle plate, a second side vertical frame and a base panel, the second upper plate is horizontally fixed at the top end of the second side vertical frame, the base panel is horizontally fixed at the bottom end of the second side vertical frame, the second middle plate is horizontally fixed on the second side vertical frame and is close to the second upper plate, and the second upper plate and the second middle plate of the eluent collecting pipe fixing frame are provided with eluent collecting pipe position holes for placing an eluent collecting pipe.
2. The solid phase extraction eluent collection device of claim 1, wherein a frame slot is provided on the second upper plate of the eluent collection tube holder, and the base frame of the solid phase extraction column holder can be fixed in the frame slot.
3. The solid phase extraction eluate collection device of claim 1, wherein the base panel of the eluate collection tube holder is provided with an eluate collection tube slot, and the solid phase extraction column position hole, the eluate collection tube position hole and the eluate collection tube slot are located on a same axis.
4. The apparatus for collecting eluent for solid-phase extraction according to claim 1, wherein the handle at the upper end of the solid-phase extraction column can be clamped by the hole at the position of the solid-phase extraction column fixing frame on the first upper plate of the solid-phase extraction column fixing frame.
5. The solid phase extraction eluent collection device of claim 1, wherein the base frame of the solid phase extraction column holder is comprised of four rims.
6. The solid phase extraction eluent collection device of claim 1, wherein an upper end of the eluent collection tube is higher than a second upper plate of the eluent collection tube holder.
7. The solid phase extraction eluent collection device of claim 1, wherein a lower end of the solid phase extraction column is disposed within a tube orifice of the eluent collection tube.
8. The solid phase extraction eluate collection device of claim 1, wherein the number of solid phase extraction column site pores and the eluate collection site pores is from 1 to 100.
9. The solid phase extraction eluate collection device of claim 1, wherein the number of solid phase extraction column site pores and the eluate collection site pores is 30-90.
10. The solid-phase extraction eluent collection device of claim 1, wherein the solid-phase extraction column holder and the eluent collection tube holder are made of plastic or metal.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202020349606.7U CN211798967U (en) | 2020-03-19 | 2020-03-19 | Solid phase extraction eluent collection device |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202020349606.7U CN211798967U (en) | 2020-03-19 | 2020-03-19 | Solid phase extraction eluent collection device |
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| CN211798967U true CN211798967U (en) | 2020-10-30 |
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