CN211798243U - Microneedle patch - Google Patents
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- CN211798243U CN211798243U CN201922143805.2U CN201922143805U CN211798243U CN 211798243 U CN211798243 U CN 211798243U CN 201922143805 U CN201922143805 U CN 201922143805U CN 211798243 U CN211798243 U CN 211798243U
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Abstract
The utility model discloses a micropin paster, including micropin array, fixed connection layer and moisturizing layer, the first surface on fixed connection layer is located to the micropin array, the second surface on fixed connection layer is located to the moisturizing layer, the fixed connection layer is located between micropin array and the moisturizing layer, be equipped with a plurality of infiltration passageways on the fixed connection layer, infiltration passageway runs through fixed connection layer to intercommunication micropin array and moisturizing layer. The microneedle patch can prevent dry skin on the surface layer caused by insufficient water supply on the surface layer of the skin in the treatment process, and further effectively prevent hypertrophic scar from being formed.
Description
Technical Field
The utility model relates to a medical treatment beauty technical field, concretely relates to micropin paster.
Background
As a novel transdermal drug delivery method, the microneedle is penetrated into the skin to promote the transdermal delivery of the drug or the active substance on the premise of not stimulating subcutaneous pain receptors and blood vessels, so that the pain of patients is relieved, and the drug or the active substance in the microneedle can be effectively dissolved in the subcutaneous part, so that the beautifying effect can be quickly achieved.
Scars are the traces left by wound healing and are also the final result of tissue repair healing; in some individuals, abnormalities in the repair process can lead to tissue hyperproliferation to form hypertrophic scars, which are common skin conditions affecting aesthetic appearance, preferably from trauma at the depth of the lesion and only the dermis, occasionally also from deeper wounds and surgical incisions.
The existing scar removing methods comprise a silicon compression scar removing therapy and an injection scar removing therapy, wherein the silicon compression scar removing therapy mainly takes a silica gel patch as a main part and has the main effects of compressing and driving scars to dissipate, and silicone oil molecules in the silicon compression scar removing therapy can be diffused to local tissues to accelerate the softening of the local tissues and the dissipation of the scars.
However, the silicon compression scar-removing therapy has long attaching time, and the skin surface layer is easy to be withered due to insufficient water supply of the skin surface layer in the treatment process, and excessive ossein is generated to form hypertrophic scars.
Disclosure of Invention
An object of the utility model is to provide a micropin paster, this micropin paster can prevent to lead to the dry and dry of top layer skin because of the untimely supply of skin top layer moisture among the treatment process easily, and then effectively prevents to form the hyperplasia scar.
The technical scheme is as follows:
microneedle paster, including microneedle array, fixed connection layer and moisturizing layer, the first surface on fixed connection layer is located to the microneedle array, the second surface on fixed connection layer is located to the moisturizing layer, the fixed connection layer is located between microneedle array and the moisturizing layer, be equipped with a plurality of infiltration passageways on the fixed connection layer, infiltration passageway runs through fixed connection layer to communicate microneedle array and moisturizing layer.
Through the setting, the moisturizing layer sees through the infiltration passageway on the fixed connection layer and adsorbs the tissue exudate of skin wound, the stratum corneum of micro needle array physical damage hypertrophic scar, the moisturizing layer is again through infiltration passageway release moisture softening top layer cutin skin, the fixed connection layer sticiss the skin surface and prevents that uneven hyperplasia tissue from appearing in the skin, this micro needle paster can prevent to be too late to supply moisture because of the skin top layer, and lead to top layer skin withering, effectively prevent to produce excessive collagen and form hypertrophic scar, make skin more pleasing to the eye.
In some embodiments, the fixed connection layer comprises a sheet-shaped base block and reinforcing fibers, the reinforcing fibers are connected with the sheet-shaped base block and support the sheet-shaped base block, and the permeation channel is arranged on the sheet-shaped base block. The reinforcing fiber improves the stability of the flaky base block, so that the flaky base block is not easy to deform, and the moisturizing layer can smoothly absorb tissue seepage and supplement moisture to keep the moisture balance of the skin.
In some embodiments, the reinforcing fibers are uniformly distributed on the surface of the sheet-shaped base block in a net shape and form a plurality of grids, and the permeation channel is arranged in the center of the grids. The reinforcing fibers are uniformly distributed on the surface of the flaky base block in a net shape, so that the stability of the reinforcing fibers to the flaky base block is improved, and the penetration channels are arranged on the uniformly distributed grids, so that the moisturizing layer can uniformly supplement moisture to the surface of the skin, and the moisturizing effect is better.
In some embodiments, fixing holes are formed at the intersections of the side lines of the meshes formed by the reinforcing fibers, and the microneedle array comprises a plurality of microneedle bodies which are arranged in the fixing holes. The microneedle body is arranged in the fixing hole, so that the stability of the microneedle body is improved, and the microneedle body is not easy to displace.
In some embodiments, the front end of the microneedle body is conical, the rear end of the microneedle body is cylindrical, the rear end of the microneedle body is connected with the inner wall of the fixing hole, and the front end of the microneedle body extends out of the fixing hole. The microneedle body is columnar one end and is connected with the inner wall of the fixed hole, so that the microneedle body is not easy to displace, and the conical end of the microneedle patch extends out of the fixed hole, thereby being beneficial to physically destroying the stratum corneum of the hyperplastic scar and smoothly conveying the active substance filled in the microneedle to the wound.
In some embodiments, the edges of the mesh include a first edge, a second edge, a third edge, and a fourth edge, and the first edge, the second edge, the third edge, and the fourth edge respectively coincide with corresponding edges of adjacent meshes. The first side line, the second side line, the third side line and the fourth side line are respectively overlapped with the corresponding side lines of the adjacent grids, so that the required materials for manufacturing the reinforced fibers are reduced, the production cost is reduced, and meanwhile, the reasonable use of usable space is facilitated.
In some embodiments, the first edge, the second edge, the third edge, and the fourth edge enclose the mesh in a rectangular shape. The grid is arranged to be rectangular, so that the usable space on the surface of the flaky substrate can be reasonably utilized, and the microneedle array and the permeation channel are reasonably and uniformly distributed.
In some embodiments, the moisture retention layer includes a non-woven fabric and a water-based gel disposed on the non-woven fabric, the water-based gel is disposed between the non-woven fabric and the fixed connection layer, and the water-based gel is uniformly distributed on the non-woven fabric and covers the non-woven fabric. The non-woven fabric and the water-based gel are combined to form a moisturizing layer, so that the non-woven fabric can prevent the water of the water-based gel from losing easily, and the moisturizing effect is ensured; in addition, the non-woven fabric has good air permeability, which is beneficial to the wound healing of patients.
In some of these embodiments, the surface area of the moisturizing layer is greater than the surface area of the anchor tie layer, which is located in the middle of the surface of the moisturizing layer. The surface area setting with the moisturizing layer is greater than the surface area on fixed connection layer, is favorable to improving moisture content, avoids the paster because of attached moisture supply not enough for a long time and leads to the dry and withered of top layer skin, and then effectively prevents to form the hyperplasia scar.
In some embodiments, a part of one side of the moisturizing layer connected with the fixed connecting layer is exposed to be in direct contact with the outside air, and a protective film is arranged on the moisturizing layer and covers the part of the moisturizing layer exposed to be in direct contact with the outside air. The protective film prevents the moisturizing layer from directly contacting with the outside air, and is favorable for protecting the moisturizing layer.
Drawings
Fig. 1 is a schematic view of the overall structure of a microneedle patch according to an embodiment of the present invention.
Fig. 2 is a side view of a microneedle patch in an embodiment of the invention.
Fig. 3 is a schematic structural diagram of a fixing connection layer in the microneedle patch according to an embodiment of the present invention.
Description of reference numerals:
10. a microneedle array; 11. a microneedle body; 20. fixing the connecting layer; 21. a sheet-like base block; 22. a reinforcing fiber; 23. a first edge line; 24. a second edge line; 25. a third edge line; 26. a fourth edge line; 30. a moisture retention layer; 31. non-woven fabrics; 32. an aqueous gel; 40. a permeate channel; 50. a fixing hole; 60. and (5) protecting the film.
Detailed Description
In order to facilitate understanding of the present invention, the present invention will be described more fully hereinafter with reference to the accompanying drawings. The preferred embodiments of the present invention are shown in the drawings. The invention may, however, be embodied in many different forms and should not be construed as limited to the embodiments set forth herein. Rather, these embodiments are provided so that this disclosure will be thorough and complete.
It will be understood that when an element is referred to as being "secured to" another element, it can be directly secured to the other element or intervening elements may also be present. When an element is referred to as being "connected" to another element, it can be directly connected to the other element or intervening elements may also be present. When an element is referred to as being "mounted on" another element, it can be directly mounted on the other element or intervening elements may also be present. When an element is referred to as being "on" another element, it can be directly on the other element or intervening elements may also be present.
Unless defined otherwise, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this invention belongs. The terminology used in the description of the invention herein is for the purpose of describing particular embodiments only and is not intended to be limiting of the invention. As used herein, the term "and/or" includes any and all combinations of one or more of the associated listed items.
As shown in fig. 1 and 2, the microneedle patch includes a microneedle array 10 loaded with an active substance, a fixing connection layer 20, and a moisture retention layer 30, the microneedle array 10 is arranged on a first surface of the fixed connection layer 20, the moisture retention layer 30 is arranged on a second surface of the fixed connection layer 20, the fixed connection layer 20 is located between the microneedle array 10 and the moisture retention layer 30, the fixed connection layer 20 comprises a sheet-shaped base block 21 and reinforcing fibers 22, in the present embodiment, the sheet-shaped base block 21 is silicone gel, the reinforcing fibers 22 are connected to the sheet-shaped base block 21 and support the sheet-shaped base block 21, a plurality of permeation channels 40 are arranged on the sheet-shaped base block 21, the permeation channels 40 penetrate through the sheet-shaped base block 21 and are communicated with the microneedle array 10 and the moisturizing layer 30, in one embodiment, the moisture-retaining layer 30 is formed by uniformly coating a high moisture-retaining aqueous gel 32 having an appropriate water content on the nonwoven fabric 31.
Before the hypertrophic scar tissue is not formed, the moisturizing layer 30 can permeate the permeation channel 40 on the sheet-shaped base block 21 to adsorb tissue seepage of the skin breach, meanwhile, the active matters in the microneedle body 11 accelerate the skin growth, and the silicone oil and the horse fat in the sheet-shaped base block 21 form a hydrophobic protective layer; when hypertrophic scars are formed, the cuticle of the hypertrophic scars is physically broken by the microneedle body 11, moisture is released by the moisturizing layer 30 through the permeation channel 40 of the fixed connecting layer 20 to soften cutin on the surface layer to treat the skin, grease molecules in the flaky base block 21 are diffused to form a protective layer, the fixed connecting layer 20 is tightly pressed on the surface of the skin to prevent uneven hyperplastic tissues from appearing on the skin, and the dry skin on the surface layer is prevented from being withered due to the fact that the moisture is not supplied to the surface layer of the skin in the whole process, and excessive collagen is generated to form the hypertrophic scars; the reinforcing fibers 22 improve the stability of the sheet-shaped base block 21, so that the sheet-shaped base block 21 is not easy to deform, and the moisturizing layer 30 can smoothly absorb tissue seepage and supplement water to keep the moisture balance of the skin; the non-woven fabric 31 and the water-based gel 32 are combined to form the moisturizing layer 30, the non-woven fabric 31 can prevent the water of the water-based gel 32 from losing easily, and the moisturizing effect is guaranteed; in addition, the non-woven fabric 31 has good air permeability, which is beneficial to wound healing of patients.
As shown in fig. 3, the reinforcing fibers 22 are uniformly distributed on the surface of the sheet-shaped base block 21 in a net shape, and form a plurality of grids, and the permeation channel 40 is arranged at the center of the grids; the reinforcing fibers 22 are uniformly distributed on the surface of the flaky base block 21 in a net shape, so that the stability of the reinforcing fibers 22 to the flaky base block 21 is improved, and the permeation channels 40 are arranged on the uniformly distributed grids, so that the moisturizing layer 30 can uniformly supplement moisture to the skin surface, and the moisturizing effect is better.
Fixing holes 50 are formed in the intersections of the sidelines of the grids formed by the reinforcing fibers 22, a plurality of microneedle bodies 11 of the microneedle array 10 are arranged in the fixing holes 50, the front ends of the microneedle bodies 11 are conical, the rear ends of the microneedle bodies 11 are cylindrical, the rear ends of the microneedle bodies 11 are connected with the inner wall of the fixing holes 50, and the front ends of the microneedle bodies extend out of the fixing holes 50; the one end that micropin body 11 is the column is connected with the inner wall of fixed orifices 50, makes micropin body 11 be difficult to take place the displacement, and the micropin paster is the one end of taper and stretches out from fixed orifices 50, is favorable to the cuticle of physical destruction hyperplasia scar, carries the active matter that adorns in the micropin smoothly to the wound.
The side lines of the grid comprise a first side line 23, a second side line 24, a third side line 25 and a fourth side line 26, the first side line 23, the second side line 24, the third side line 25 and the fourth side line 26 are respectively superposed with the corresponding side lines of the adjacent grid, and the first side line 23, the second side line 24, the third side line 25 and the fourth side line 26 enclose the grid into a rectangular shape; the method is favorable for reducing the required materials for manufacturing the reinforcing fibers 22, reducing the production cost, and arranging the grids into a rectangular shape, thereby being favorable for reasonably utilizing the available space on the surface of the flaky base block 21 and reasonably and uniformly distributing the microneedle array 10 and the permeation channel 40.
The part of one surface of the moisturizing layer 30, which is connected with the fixed connecting layer 20, is exposed to be in direct contact with the outside air, a protective film 60 is arranged on the moisturizing layer 30, and the protective film 60 covers the part of the moisturizing layer 30, which is exposed to be in direct contact with the outside air; the protective film 60 prevents the moisture retention layer 30 from directly contacting with the outside air, which is beneficial to protecting the moisture retention layer 30 and preventing the moisture of the moisture retention layer 30 from easily running off.
The reinforcing fibers 22 may be cotton fibers, polyester fibers, spandex fibers.
The first embodiment is as follows:
the active substance in the microneedle array 10 of the microneedle patch is prepared from the following components: 20 parts of small molecular sodium hyaluronate (with the molecular weight of 1KD-10kD, the source of the manufacturer is Huaxi biotechnology limited company, the same below), 64 parts of water, 5 parts of PVP, 8 parts of steroid, 1.5 parts of panthenol, 1 part of asiaticoside and 0.5 part of fibroblast growth factor; the reinforcing fibers 22 are cotton fibers with square meshes;
the sheet-like base block 21 is prepared from the following components: 48 parts of polydimethylsiloxane, 36 parts of simethicone, 4 parts of amyl glycol, 3 parts of horse fat, 3 parts of snake oil, 5 parts of stearyl alcohol and 1 part of PEG-7 hydrogenated ricinoleic acid;
the non-woven fabric 31 is a one-way elastic non-woven fabric 31, and the aqueous gel 32 is prepared from the following components: 45 parts of water, 40 parts of glycerol, 5.5 parts of sodium polyacrylate, 6 parts of carrageenan, 3 parts of sodium carboxymethylcellulose, 0.15 part of tartaric acid, 0.2 part of dihydroxyaluminium glycinate, 0.05 part of disodium ethylene diamine tetraacetate and 0.1 part of macromolecular hyaluronic acid or sodium salt.
The preparation method of the microneedle patch for improving the hypertrophic scar of the skin comprises the following steps:
(1) mixing horse fat, snake oil, stearyl alcohol, PEG-7 hydrogenated ricinoleic acid, amyl glycol and dimethyl silicone oil at normal temperature and normal pressure at 450rpm/min, stirring for 5min, adding polydimethylsiloxane while stirring, mixing at 450rpm/min, and stirring for 15min to obtain silica gel liquid. Spreading regular reticular fibers on a smooth stainless steel plate, enabling a reticular point columnar clapboard to be just pressed at the intersection point of the reticular fiber net and the fiber mesh position, fixing the reticular point columnar clapboard and the stainless steel plate, coating a silica gel glue solution on the surface of the reticular point columnar clapboard, filling the reticular point columnar clapboard in the clapboard, heating the reticular point columnar clapboard at 120 ℃ for 15min, slightly stripping the clapboard after the gel is cured and formed, and obtaining a matrix mesh-shaped silica gel layer (fixed connection layer).
(2) Uniformly dissolving the active substances of the microneedle array, namely the steroid, panthenol, asiaticoside and fibroblast growth factor in water, then adding the micromolecular sodium hyaluronate and PVP into the aqueous solution while stirring, stirring at 450rpm/min for 120min to swell and dissolve uniformly to form viscous liquid, 3500rpm/min, centrifugally degassing for 2min, injecting the prepared liquid suction pipe into a 3D printer, printing microneedles in concave holes with fiber net cross points of the prepared matrix mesh-shaped silica gel layer, and drying and molding on line by using dry air to form a silica gel composite layer carrying microneedle chips (namely the fixed connecting layer carrying the microneedle array).
(3) Adding tartaric acid into water according to the components in the aqueous gel, stirring for 2min at 300rpm/min to form a uniform water phase, adding sodium polyacrylate, carrageenan, sodium carboxymethylcellulose, aluminum glycollate, disodium ethylenediamine tetraacetate and macromolecular hyaluronic acid sodium salt (molecular weight is 1500 + 1800kD, the manufacturer source is the same as Huaxi biological science and technology Limited company) into glycerol, stirring for 5min at 450rpm/min to form a uniformly dispersed oil phase, rapidly adding the water phase into the oil phase, stirring at 450rpm/min in vacuum for 10min, uniformly coating the oil phase on the surface of the unidirectional elastic non-woven fabric, sealing, standing and crosslinking for 8 hours to form a protective layer.
(4) The method comprises the steps of pressing a silicone gel layer cutting layer of a microneedle chip into a required shape on the surface of aqueous gel, enabling microneedles to face upwards, covering a protective film, and cutting to form the intelligent microneedle patch for improving the hypertrophic scars of the skin.
Example two:
the active in the microneedle array 10 in the microneedle patch consisted of the following components: 18 parts of micromolecular sodium hyaluronate, 62 parts of water, 5 parts of PVP, 10 parts of steroid, 2 parts of panthenol, 2.5 parts of asiaticoside and 0.5 part of fibroblast growth factor;
the reinforcing fiber 22 is made of polyester fiber with square meshes; the sheet-like base block 21 is composed of the following components: 52 parts of polydimethylsiloxane, 32 parts of dimethyl silicone oil, 4 parts of amyl glycol, 2 parts of horse fat, 3 parts of snake oil, 5 parts of stearyl alcohol and 2 parts of PEG-7 hydrogenated ricinoleic acid;
the non-woven fabric 31 is a one-way elastic non-woven fabric 31, and the aqueous gel 32 consists of the following components: 50 parts of water, 35 parts of glycerol, 5.5 parts of sodium polyacrylate, 6 parts of carrageenan, 3 parts of sodium carboxymethylcellulose, 0.15 part of tartaric acid, 0.2 part of dihydroxyaluminium glycinate, 0.05 part of disodium ethylene diamine tetraacetate and 0.1 part of macromolecular hyaluronic acid or sodium salt.
The preparation method is the same as that of example 1.
Comparative example 1
This comparative example is used for and the utility model discloses the microneedle paster that prepares for adopting the soluble microneedle that ordinary preparation method prepared is horizontal contrast on the experimental result, and the microneedle array formula is: 20 parts of micromolecular sodium hyaluronate, 64 parts of water, PVP5 parts, 8 parts of steroid, 1.5 parts of panthenol, 1 part of asiaticoside and 0.5 part of fibroblast growth factor, wherein the base material for connecting the microneedle array into a sheet is polyvinylpyrrolidone K90 ethanol solution in a mass ratio of (1: 2.5)
The preparation method comprises the following steps: sucking 0.1ml of the prepared microneedle array aqueous solution to a female die, centrifuging at 3500rpm/min for 5min, removing redundant liquid on the surface of the die, sucking 0.2ml of base material solution, injecting the base material solution to the surface of the female die, centrifuging at 2500rpm/min for 5min, drying in a dryer for 8h, demolding the microneedle chip, and adhering the prepared pressure-sensitive adhesive with the backing to the opposite side of the microneedle chip array to obtain the microneedle patch capable of being adhered to the skin.
Example three:
the method comprises purchasing 22 big-ear white rabbits with negligible male and female parts and body weight of 1.8-2.2kg, adaptively feeding for 7 days, observing each white rabbit, and feeding water without obvious abnormality, and bringing into experiment. The establishment of the scar animal model comprises the steps of carrying out anesthesia by injecting a pentobarbital solution with the concentration of 30g/L into ear edge veins, making a circular wound surface with the diameter of 1cm on the ventral side of a rabbit ear along a long axis, wherein 2 parts of each ear are spaced by about 3.0cm, completely cutting off the whole skin, and naturally healing the wound surface to form a hyperplastic scar hard block after 21 days of skin formation. No unhealed or unhealed wound surface infection and formation of new scar tissue.
Grouping, namely selecting 15 rabbits to randomly divide into a blank group, a positive control group, an example 1 group (using the microneedle patch of example 1), an example 2 group (using the microneedle patch of example 2) and a comparative example 1 group (using the microneedle patch of comparative example 1), wherein each group comprises 3 rabbit ears and 12 wound surfaces. The positive control group is a commercially available medical scar patch (produced by beihao medical science and technology limited, guangzhou), the positive control group, the example 1 group and the example 2 group begin to apply corresponding patches 24h after the scar model is established, wherein the blank group is a scar model rabbit without any intervention treatment, the commercially available medical scar patch is cut into patches with proper sizes by the positive control group, the patches are applied to the surfaces of the newly-generated scar patches of rabbit ears and fixed, the application frequency is 1 time/day and is continuously 60 days, the example 1 group, the example 2 group and the comparative example 1 group are applied by corresponding microneedle patches 1 time on the 1 st, 5 th, 9 th, 13 th, 20 th and 27 th days in a 40-day period, and the following table is observed and scored on the 40 th day and 60 th day.
And (3) evaluating the curative effect: the curative effect evaluation is evaluated by a Vancouver Scar Scale (VSS). The stability of the repeated evaluation is reliable, and the intra-group correlation coefficient (ICC) is 0.81. The scale is a descriptive evaluation mainly in terms of colour, thickness, softness etc. the higher the score, the heavier the scar is.
Wenggol scar scale scoring standard
Statistical treatment: statistical analysis of the data was performed using SPSS18.0 software. The result is expressed by x +/-SD, and the blank group and the positive control group are respectively compared, and the difference of P <0.05 is statistically significant when the blank group is compared with the microneedle group, so that the effect of the test sample is proved.
As a result: no difference in VSS score before scar intervention was assessed in groups 4. Through statistical analysis and repeated measurement variance analysis, the VSS values of the scars of the positive control group, the example 1 group, the example 2 group and the comparative example 1 group after dry prognosis are all reduced along with the increase of the treatment time, the positive control group has a certain improvement effect on the intervention of the scars by analyzing the VSS mean value, but the VSS mean value of the positive control group is not significantly different (P >0.05) and has no statistical significance, the VSS values of the examples 1, the example 2 group and the comparative example 1 group after dry prognosis are all reduced (P <0.05), the VSS reduction is obvious, has statistical significance and significant difference, and has good improvement effect on the scars, while the VSS values of the comparative example 1 group and the example 1 and the comparative example 2 group after dry prognosis (P >0.05) have no statistical significance, but the data show that the VSS values of the examples 1 and the example 2 group after dry prognosis are greatly reduced compared with the VSS values of the comparative example 1 group after dry prognosis, the statistical data of the effect of the microneedle patch of the present invention on improving scar is better than that of the ordinary microneedle patch, and is shown in table 1.
TABLE 1 comparison of VSS values before and after intervention of local scarring of rabbit ears
The above embodiments only represent the specific embodiments of the present invention, and the description thereof is more specific and detailed, but not construed as limiting the scope of the present invention. It should be noted that various alternatives, modifications and variations can be devised by those skilled in the art without departing from the spirit and scope of the present invention.
Claims (10)
1. Microneedle paster, its characterized in that, including microneedle array, fixed connection layer and moisturizing layer, the first surface on fixed connection layer is located to the microneedle array, the second surface on fixed connection layer is located to the moisturizing layer, the fixed connection layer is located between microneedle array and the moisturizing layer, be equipped with a plurality of infiltration passageways on the fixed connection layer, infiltration passageway runs through fixed connection layer to feed through microneedle array and moisturizing layer.
2. A microneedle patch according to claim 1, wherein the fixed connection layer comprises a sheet-like base block and reinforcing fibers connected to and supporting the sheet-like base block, and the permeation pathway is provided on the sheet-like base block.
3. A microneedle patch according to claim 2, wherein the reinforcing fibers are uniformly distributed in a net shape on the surface of the sheet-like base block and form a plurality of meshes, and the permeation pathway is provided at the center of the meshes.
4. A microneedle patch according to claim 3, wherein fixing holes are provided at the intersections of the side lines of the plurality of meshes formed by the reinforcing fibers, the microneedle array comprises a plurality of microneedle bodies, and the microneedle bodies are provided in the fixing holes.
5. The microneedle patch according to claim 4, wherein the microneedle body has a tapered front end and a cylindrical rear end, the rear end of the microneedle body is connected to an inner wall of the fixing hole, and the front end thereof protrudes from the fixing hole.
6. A microneedle patch according to claim 4, wherein the edges of the lattice include first, second, third and fourth edges that respectively coincide with corresponding edges of an adjacent lattice.
7. A microneedle patch according to claim 6, wherein the first, second, third and fourth edges enclose a lattice into a rectangular shape.
8. A microneedle patch according to any one of claims 1 to 7, wherein the moisture-retaining layer comprises a nonwoven fabric and an aqueous gel disposed on the nonwoven fabric, the aqueous gel being disposed between the nonwoven fabric and the anchor layer, the aqueous gel being uniformly distributed on the nonwoven fabric and covering the nonwoven fabric.
9. A microneedle patch according to claim 8, wherein the surface area of the moisture-retentive layer is larger than the surface area of the anchor connection layer, and the anchor connection layer is located at a position intermediate to the surface of the moisture-retentive layer.
10. A microneedle patch according to claim 9, wherein a part of a side of the moisture retention layer connected to the anchor connection layer is exposed to be in direct contact with the outside air, and a protective film is provided on the moisture retention layer to cover a part of the moisture retention layer exposed to be in direct contact with the outside air.
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| CN201922143805.2U CN211798243U (en) | 2019-12-03 | 2019-12-03 | Microneedle patch |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN115998638A (en) * | 2022-10-21 | 2023-04-25 | 沈阳药科大学 | Hydrogel patch of integrated microneedle and preparation method thereof |
| CN117159510A (en) * | 2023-10-16 | 2023-12-05 | 中科微针（北京）科技有限公司 | Microneedle membrane containing breathable substrate material and preparation method thereof |
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2019
- 2019-12-03 CN CN201922143805.2U patent/CN211798243U/en active Active
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN115998638A (en) * | 2022-10-21 | 2023-04-25 | 沈阳药科大学 | Hydrogel patch of integrated microneedle and preparation method thereof |
| CN115998638B (en) * | 2022-10-21 | 2024-10-18 | 沈阳药科大学 | Hydrogel patch of integrated microneedle and preparation method thereof |
| CN117159510A (en) * | 2023-10-16 | 2023-12-05 | 中科微针（北京）科技有限公司 | Microneedle membrane containing breathable substrate material and preparation method thereof |
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