CN211706445U

CN211706445U - Nanofiltration device

Info

Publication number: CN211706445U
Application number: CN201922017489.4U
Authority: CN
Inventors: 岳红; 李敏; 王世鹏
Original assignee: Changchun Puhua Pharmaceutical Co ltd
Current assignee: Changchun Puhua Pharmaceutical Co ltd
Priority date: 2019-11-20
Filing date: 2019-11-20
Publication date: 2020-10-20
Anticipated expiration: 2029-11-20

Abstract

The utility model discloses a nanofiltration device for the liquid medicine purification, including head tank and the film element that is used for filtering the liquid medicine, the head tank passes through the feed line with the entry of film element and links to each other, is equipped with the high-pressure pump in the feed line, and the export of film element passes through the feed back pipe with the head tank and links to each other, and the film element still links to each other has the liquid tank that perspires that is used for holding the transudate. The nanofiltration device is pressure driven by a high pressure pump. Under the action of external pressure, the liquid medicine flows in the channel of the membrane element, the solvent and the soluble micromolecule substance permeate the membrane to form a permeate liquid, the soluble macromolecule substance is intercepted by the membrane and forms a concentrated solution which flows back to the raw material tank, and then the concentrated solution is pumped into the channel of the membrane element. The liquid medicine is continuously circulated in the nanofiltration device, and the drug molecules are separated from impurities along with the continuous outflow of the permeate liquid, so that the concentration and purification of the liquid medicine are realized. Compared with reduced-pressure low-temperature distillation equipment, the nanofiltration device has simpler structure and larger treatment capacity, and can obviously improve the production efficiency of enterprises.

Description

Nanofiltration device

Technical Field

The utility model relates to a pharmaceutical chemical industry technical field, in particular to receive and strain device.

Background

In pharmaceutical production, after a drug is generated through reaction, liquid medicine needs to be purified, in the prior art, the drug and impurities are generally purified in a distillation mode by utilizing different boiling points, but the main components of part of the liquid medicine are easy to generate impurities after being heated, so that the quality of the drug is influenced. In order to solve the problems, a rotary evaporator is adopted by some enterprises to carry out distillation under the condition of reduced pressure and low temperature, but the reduced pressure and low temperature distillation equipment has the problems of complex structure, low production efficiency and the like.

Therefore, how to provide a solution that can improve the production efficiency of the purification of the liquid medicine and simplify the structure of the equipment is a technical problem that needs to be solved urgently by those skilled in the art.

SUMMERY OF THE UTILITY MODEL

The utility model aims at providing a nanofiltration device, it has simplified the structure of purification equipment through the impurity in the filterable mode filtering liquid medicine of membrane, has improved production efficiency.

In order to achieve the above object, the utility model provides a nanofiltration device for the liquid medicine purification, include the head tank and be used for filtering the film element of liquid medicine, the head tank with the entry of film element passes through feed line and links to each other, be equipped with the high-pressure pump among the feed line, the export of film element with the head tank passes through the feed back pipe and links to each other, the film element still even has the permeate-out fluid reservoir that is used for holding permeate liquid.

Preferably, the membrane element comprises a cylindrical shell, the shell is provided with a filter membrane which is coaxial with the shell, the feeding pipeline and the feed back pipe are both communicated with the inner side of the filter membrane, and the permeate liquid tank is communicated with the outer side of the filter membrane through a permeate pipe.

Preferably, the feeding pipeline and the material return pipe are respectively provided with a pressure sensor before a membrane and a pressure sensor after the membrane, and the device further comprises a control box, wherein the pressure sensor before the membrane, the pressure sensor after the membrane and the high-pressure pump are all connected with the control box.

Preferably, a liquid medicine flow meter for measuring the liquid medicine backflow amount is further arranged in the material return pipe, and the liquid medicine flow meter is connected with the control box.

Preferably, the permeate outlet pipe is provided with a permeate liquid flow meter for measuring the flow rate of the permeate liquid, and the permeate liquid flow meter is connected with the control box.

Preferably, the raw material tank is provided with a raw material liquid level meter, and the raw material liquid level meter is connected with the control box so as to stop the raw material pump when the liquid level in the raw material tank is lower than a preset value.

The utility model provides a nanofiltration device for the liquid medicine purification, including head tank and the film element that is used for filtering the liquid medicine, the head tank passes through the feed line with the entry of film element and links to each other, is equipped with the high-pressure pump in the feed line, and the export of film element passes through the feed back pipe with the head tank and links to each other, and the film element still even has the liquid jar of penetrating out that is used for holding the transudate.

The nanofiltration device is pressure driven by a high pressure pump. Under the action of external pressure, the liquid medicine flows in the channel of the membrane element, the solvent and the soluble micromolecule substance permeate the membrane to form a permeate liquid, the soluble macromolecule substance is intercepted by the membrane and forms a concentrated solution which flows back to the raw material tank, and then the concentrated solution is pumped into the channel of the membrane element. The liquid medicine is continuously circulated in the nanofiltration device, and the concentration of the liquid medicine is gradually increased along with the continuous outflow of the permeate liquid. After the liquid medicine reaches the expected concentration, the liquid medicine is discharged from the raw material tank and the pipeline system, so that the medicine molecules are separated from impurities, and the concentration and purification of the liquid medicine are realized. Compared with reduced-pressure low-temperature distillation equipment, the nanofiltration device has simpler structure and larger treatment capacity, and can obviously improve the production efficiency of enterprises.

Drawings

In order to more clearly illustrate the embodiments of the present invention or the technical solutions in the prior art, the drawings required to be used in the description of the embodiments or the prior art will be briefly described below, it is obvious that the drawings in the following description are only embodiments of the present invention, and for those skilled in the art, other drawings can be obtained according to the provided drawings without creative efforts.

Fig. 1 is a schematic structural diagram of a nanofiltration device provided by the utility model.

Wherein the reference numerals in figure 1 are:

a raw material tank 1, a membrane element 2, a high-pressure pump 3, a permeate liquid tank 4, a control box 5, a pressure sensor 6 before membrane, a pressure sensor 7 after membrane, a liquid medicine flow meter 8 and a permeate liquid flow meter 9.

Detailed Description

The technical solutions in the embodiments of the present invention will be described clearly and completely with reference to the accompanying drawings in the embodiments of the present invention, and it is obvious that the described embodiments are only some embodiments of the present invention, not all embodiments. Based on the embodiments in the present invention, all other embodiments obtained by a person skilled in the art without creative work belong to the protection scope of the present invention.

In order to make the technical field of the present invention better understand, the present invention will be described in detail with reference to the accompanying drawings and the detailed description.

Referring to fig. 1, fig. 1 is a schematic structural diagram of a nanofiltration device provided by the present invention.

The utility model provides a receive and strain device is used for the liquid medicine purification. As shown in fig. 1, the nanofiltration device includes a raw material tank 1, a membrane element 2, a high-pressure pump 3, and a permeate liquid tank 4. The raw material tank 1 is used for storing liquid medicine and is connected with an inlet of the membrane element 2 through a feeding pipeline, the high-pressure pump 3 is arranged in the feeding pipeline, specifically, the feeding pipeline is divided into two sections of feeding pipes, one section of the feeding pipe is connected with the raw material tank 1 and the inlet of the high-pressure pump 3, and the other section of the feeding pipe is connected with an outlet of the high-pressure pump 3 and the inlet of the membrane element 2. The liquid medicine is pressurized by a high-pressure pump 3 and then enters a membrane element 2, the solvent and the soluble micromolecule substances in the liquid medicine penetrate through the membrane under the action of pressure to form a permeate liquid, and the soluble macromolecule substances are intercepted by the membrane to form a concentrated solution. The raw material outlet of the membrane element 2 is connected with the top of the raw material tank 1 through a return pipe, and the permeate liquid outlet is connected with the permeate liquid tank through a permeate pipe. Under the drive of the high-pressure pump 3, the liquid medicine circulates between the membrane element 2 and the raw material tank 1, the concentration and the purification are realized through multiple times of filtration by the membrane element 2, and an operator recovers the liquid medicine from the nanofiltration device after the concentration is finished.

Optionally, the feed line is located below the feed tank 1 and is provided with a discharge outlet in parallel with the high pressure pump 3. In a specific embodiment of this application, but the top of head tank 1 has the top cap of switch, and operating personnel opens the top cap and pours into the liquid medicine into head tank 1. Of course, the raw material tank 1 can also be connected with a liquid medicine production device through a pipeline, and the liquid medicine directly enters the raw material tank 1 and is concentrated and purified in the nanofiltration device.

In the embodiment, the liquid medicine is purified through the nanofiltration device, so that the structure of the purification equipment is simplified. And the treatment capacity of the nanofiltration device is related to the specification of the membrane element 2, and the treatment capacity of the nanofiltration device can be improved by directly increasing the specification of the membrane element 2. Therefore, the treatment capacity of the nanofiltration device can be obviously increased compared with that of reduced pressure low temperature distillation equipment, and further the production efficiency of enterprises is improved.

Optionally, in the present application, the membrane element 2 adopts a cross-flow filtration principle to purify the liquid medicine. Specifically, the liquid medicine flows along the direction parallel to the filter membrane, the permeate outlet is positioned at the lower part of the membrane element 2, the liquid medicine can generate a shearing force action in the vertical flowing direction under the action of pressure, the micromolecules penetrate through the filter membrane at the shearing force to form permeate, and meanwhile, under the action of the thrust force of the liquid medicine flowing, a pollution layer on the surface of the filter membrane is kept at a thin level, so that the filter membrane is guaranteed to have good permeability all the time.

Specifically, the membrane element 2 comprises a cylindrical shell and a cylindrical filter membrane, the filter membrane is positioned in the shell and is coaxially arranged with the shell, two ends of the filter membrane are hermetically connected with the inner side wall of the shell, the inlet and the liquid medicine outlet of the membrane element 2 are respectively positioned at two end parts of the shell, and the inlet and the liquid medicine outlet are both communicated with the inner side of the filter membrane. The permeate outlet is positioned at the lower part of the shell and is communicated with the outer side of the filter membrane. In a specific embodiment of this application, the filter membrane adopts three-layer composite membrane structure, and the filtration pore diameter of three-layer membrane reduces from inside to outside in proper order, and the user also can choose the filter membrane of other structures as required for use, does not do the restriction here.

When the membrane element 2 is used for filtration, the pressure difference between both sides of the filter membrane needs to be maintained within a certain range. Thus, the feed line is provided with a pre-membrane pressure sensor 6 and the return line is provided with a flow control valve. The pressure sensor 6 in front of the membrane is connected with the control box 5, and the control box 5 is provided with a control unit such as an MCU (microprogrammed control Unit) or a PLC (programmable logic controller). The pressure difference on the two sides of the filter membrane refers to the pressure difference between the inner side and the outer side of the filter membrane, the outer side of the filter membrane is connected with the permeate liquid tank 4, and the permeate liquid tank 4 is usually kept at normal pressure, so that the control box 5 can obtain the pressure difference on the two sides of the filter membrane through gauge pressure in front of the membrane, further the outlet pressure of the high-pressure pump 3 is controlled, and the damage of the filter membrane caused by overla. Specifically, when the pressure difference between the two sides of the filter membrane is too large, the flow control valve is opened, and the flow of the liquid medicine is increased, so that the outlet flow of the high-pressure pump 3 can be reduced. Of course, if the high-pressure pump 3 employs a displacement pump, the pre-membrane pressure may be reduced by reducing the rotation speed of the high-pressure pump 3.

Optionally, a liquid medicine flow meter 8 is further arranged in the material return pipe, a transudate liquid flow meter 9 is arranged in the transudate pipe, and the transudate liquid flow meter 9 and the liquid medicine flow meter 8 are both connected with the control box 5. The control box 5 calculates the outlet flow of the high-pressure pump 3 according to the reflux amount of the liquid medicine and the flow meter of the permeate liquid, then can judge the running condition of the high-pressure pump 3 by combining the pressure before the membrane, and can adjust the parameters such as the liquid medicine flow and the pressure and the like along with the performance curve of the high-pressure pump 3. In addition, the control box 5 can increase the flow of the liquid medicine as much as possible on the basis of ensuring that the two sides of the filter membrane have enough pressure difference, thereby improving the concentration efficiency.

Optionally, as shown in fig. 1, the nanofiltration device further comprises a mounting frame, the membrane element 2, the high-pressure pump 3 and the control box 5 are connected with the mounting frame, and rollers are further arranged at the bottom of the mounting frame to facilitate an operator to move the mounting frame and adjust the position of the nanofiltration device.

In addition, the raw material tank 1 is provided with a raw material level meter, and the raw material level meter is connected with the control box 5. The liquid level in the raw material tank 1 is lower than the preset value, which indicates that a large amount of small molecules in the liquid medicine are discharged along with the permeate liquid and the liquid medicine is concentrated to the expected concentration. The control box 5 can thus stop the raw material pump, at which point the operator can discharge the liquid medicine from the liquid discharge port of the feed line for further processing. Of course, the drain port may also be connected directly to the further processing apparatus, without limitation. The nanofiltration device can also be provided with a prompter for prompting operators that the concentration of the liquid medicine is finished.

Furthermore, the feed back pipe is also provided with a pressure sensor 7 behind the membrane, the pressure sensor 7 behind the membrane is connected with the control box 5, and the smaller the pressure difference between the front of the membrane and the back of the membrane is, the smaller the pressure loss when the liquid medicine flows through the membrane element 2 is, namely, the less filtrate is pressed out of the liquid medicine. The low filtrate may be caused by the high concentration of the liquid medicine or by the clogging of the filter membrane. The control box 5 can judge whether the filter membrane is blocked or not by combining the liquid level of the raw material tank 1 and the pressure difference between the front membrane and the rear membrane, and if the filter membrane is blocked, an operator can be prompted to clean the filter membrane. In addition, in order to prolong the service cycle of the filter membrane, a filter can be arranged in the feeding pipeline and used for filtering pollutants in the liquid medicine and reducing the occurrence of the condition that the filter membrane is blocked by the pollutants. The control box 5 can also be provided with an alarm mechanism, and when the filter membrane is blocked, the alarm mechanism gives an alarm to prompt an operator to carry out cleaning operation.

In this embodiment, the nanofiltration device is provided with the control box 5, the control box 5 judges the working conditions of the filter membrane and the high-pressure pump 3 according to the pressure signals before and after the membrane, the reflux amount of the liquid medicine and the filtrate flow rate, and further adjusts the operation parameters of the nanofiltration device, thereby avoiding the damage of the filter membrane, prolonging the service life of the equipment and improving the concentration efficiency.

It is noted that, in this specification, relational terms such as first and second, and the like are used solely to distinguish one entity from another entity without necessarily requiring or implying any actual such relationship or order between such entities.

The nanofiltration device provided by the utility model is introduced in detail. The principles and embodiments of the present invention have been explained herein using specific examples, and the above descriptions of the embodiments are only used to help understand the method and its core ideas of the present invention. It should be noted that, for those skilled in the art, without departing from the principle of the present invention, the present invention can be further modified and modified, and such modifications and modifications also fall within the protection scope of the appended claims.

Claims

1. The nanofiltration device is used for purifying liquid medicine and is characterized by comprising a raw material tank (1) and a membrane element (2) used for filtering the liquid medicine, wherein the raw material tank (1) is connected with an inlet of the membrane element (2) through a feeding pipeline, a high-pressure pump (3) is arranged in the feeding pipeline, an outlet of the membrane element (2) is connected with the raw material tank (1) through a material return pipe, and the membrane element (2) is further connected with a permeate liquid tank (4) used for containing permeate liquid.

2. Nanofiltration device according to claim 1, wherein the membrane element (2) comprises a cylindrical housing having an axially arranged filtration membrane therein, wherein the feed line and the return line are both in communication with the inside of the filtration membrane, and wherein the permeate tank (4) is in communication with the outside of the filtration membrane via a permeate pipe.

3. Nanofiltration device according to claim 2, wherein the feed line and the return line are provided with a pre-membrane pressure sensor (6) and a post-membrane pressure sensor (7), respectively, and further comprising a control box (5), and wherein the pre-membrane pressure sensor (6), the post-membrane pressure sensor (7) and the high-pressure pump (3) are connected to the control box (5).

4. The nanofiltration device according to claim 3, wherein the return pipe is further provided with a liquid medicine flow meter (8) for measuring the liquid medicine return flow, and the liquid medicine flow meter (8) is connected with the control box (5).

5. Nanofiltration device according to claim 4, wherein the permeate pipe is provided with a permeate flow meter (9) for measuring the flow of permeate, the permeate flow meter (9) being connected to the control box (5).

6. Nanofiltration device according to any one of claims 3 to 5, wherein the feed tank (1) is provided with a feed level meter connected to the control box (5) for stopping the high pressure pump (3) when the liquid level in the feed tank (1) is below a preset value.