CN211689003U

CN211689003U - Sample loading device of gene sequencer

Info

Publication number: CN211689003U
Application number: CN201922364732.XU
Authority: CN
Inventors: 戴博岭
Original assignee: Tianjin Jingnuo Life Science And Technology Co ltd
Current assignee: Tianjin Shenganjia Medical Technology Co ltd
Priority date: 2019-12-25
Filing date: 2019-12-25
Publication date: 2020-10-16
Anticipated expiration: 2029-12-25

Abstract

The utility model provides a sample loading device of a gene sequencer, which comprises a loading station, a sample loading device and a sample loading device, wherein the loading station comprises a loading cylinder and a chip clamping seat arranged right below the loading cylinder; the sample tanks can synchronously move along the horizontal direction, each sample tank comprises a tank body, a feeding push rod and a discharge nozzle, each feeding push rod can be connected with a piston rod of a feeding cylinder, and when the feeding push rod of one sample tank is connected with the piston rod of the feeding cylinder, the discharge nozzle of the sample tank is arranged right above the chip clamping seat; the bottom end of a piston rod of the feeding cylinder is fixedly provided with a pressing head, the top of the feeding push rod is provided with a pressing wheel, the pressing head comprises a bottom surface and a top surface, the pressing wheel can be arranged between the bottom surface and the top surface, and when the pressing wheel is arranged between the bottom surface and the top surface, the pressing wheel and the pressing head can synchronously move along the vertical direction. The utility model discloses a piston rod of material loading cylinder cooperates the material loading push rod of a plurality of sample jars, and the manual operation has been saved to the detection of multiple sample reagent of being convenient for accomplish in a chip cassette.

Description

Sample loading device of gene sequencer

Technical Field

The utility model belongs to the technical field of it is biological, especially, relate to a device of getting ready of gene sequencer.

Background

The gene sequencing is a novel gene detection technology, can analyze and determine the complete sequence of genes from blood or saliva, predicts that a detected person possibly suffers from diseases in the future, and achieves early prevention and treatment through medicaments;

in recent years, in order to improve the detection precision, most researches on gene sequencing are carried out around gene chips, and outstanding achievements and developments are also obtained, but the conventional gene sequencer still needs manual sample loading, the efficiency is extremely low, the sequencing period is longer, and in the manual operation process, in order to ensure the accurate result of gene sequencing, a sample reagent is usually smeared on one sample as much as possible, so that the reagent waste is caused, and the production cost is increased;

in the prior art, although a sample loading device of a gene sequencer exists, in the sample loading process, when different sample tanks are switched, a discharge port of the sample tank cannot be plugged, although samples in the samples can be placed through devices such as a piston rod and the like and cannot be lost, a small amount of reagents still flow out from the discharge port of the sample tank, the value of the sample reagents is generally increased, and the detection cost is easily increased due to the fact that the reagents are wasted.

SUMMERY OF THE UTILITY MODEL

In view of this, the utility model aims at providing a device of getting one's appearance of gene sequencer to carrying out the operation of getting one's appearance to the gene sequencer automatically, improving production efficiency, avoiding the sample reagent extravagant at the discharge gate of the automatic shutoff sample jar of in-process that switches the sample jar simultaneously.

In order to achieve the above purpose, the technical scheme of the utility model is realized like this:

a sample loading device of a gene sequencer comprises

The feeding station comprises a feeding cylinder and a chip clamping seat arranged right below the feeding cylinder;

the device comprises a plurality of sample tanks capable of synchronously moving along the horizontal direction, wherein each sample tank comprises a tank body, a feeding push rod and a discharge nozzle, each feeding push rod can be connected with a piston rod of a feeding cylinder, and when the feeding push rod of one sample tank is connected with the piston rod of the feeding cylinder, the discharge nozzle of the sample tank is arranged right above a chip clamping seat;

the bottom end of a piston rod of the feeding cylinder is fixedly provided with a pressing head, the top of the feeding push rod is provided with a pressing wheel, the pressing head comprises a bottom surface and a top surface, the pressing wheel can be arranged between the bottom surface and the top surface, and when the pressing wheel is arranged between the bottom surface and the top surface, the pressing wheel and the pressing head can synchronously move along the vertical direction.

Further, this device of loading a sample still includes riser and walking frame, the riser has set firmly the slide along the horizontal direction, the walking frame pass through the slider with the slide is connected, the sample jar all sets firmly on the walking frame.

Furthermore, a connecting plate is arranged between the bottom surface and the top surface, and a piston rod of the feeding cylinder is fixedly connected with the connecting plate.

Furthermore, a supporting bar is arranged at the top of the vertical plate along the horizontal direction, and the pressing wheel is arranged above the supporting bar and moves along the length direction of the supporting bar.

Further, when a piston rod of the feeding cylinder is located at an upper limit position, the upper surface of the supporting bar and the bottom surface of the pressure head are located in the same plane.

Furthermore, a fracture is formed in the middle of the supporting bar, and when a piston rod of the feeding cylinder is located at the upper limit position, the pressure head is arranged in the fracture.

Furthermore, a slotted hole is formed in the vertical plate in the horizontal reverse direction, a connecting rod is fixedly arranged on the walking frame and penetrates through the vertical plate through the slotted hole, and the end part of the connecting rod is connected with a walking electric cylinder.

Furthermore, the vertical plate can move in the vertical direction, a supporting plate is arranged above the chip clamping seat, the discharge nozzle comprises a sleeve, the sleeve is fixedly connected with the tank body, a discharge pipe capable of moving axially along the sleeve is arranged in the sleeve, the top end of the discharge pipe is sealed, a feed hole is formed in the side wall of the top end of the discharge pipe, the bottom of the discharge pipe abuts against the step, a rubber sleeve is sleeved on the discharge pipe, one end of the rubber sleeve abuts against the bottom end of the sleeve, the other end of the rubber sleeve abuts against the step, a through hole is formed in the middle of the supporting plate, and the through hole is arranged under the discharge pipe.

Furthermore, a flanging is extended outwards from the top end of the discharge pipe, and the flanging can be tightly abutted to the end face of the top end of the sleeve.

Compared with the prior art, the utility model relates to a gene sequencer's sample loading device have following advantage:

the utility model adopts the piston rod of the feeding cylinder to match with the feeding push rods of a plurality of sample tanks, thereby being convenient for completing the detection of a plurality of sample reagents in one chip clamping seat and saving manual operation; the press head is matched with the press wheel, so that the feeding push rod and the feeding cylinder can be conveniently and quickly connected and separated; the supporting strips are adopted, so that the feeding push rod can be kept at a fixed position after one-time work is finished, and the feeding push rod is prevented from falling due to air pressure and the like; adopt the material loading pipe cooperation that sleeve pipe and top were sealed for can seal the ejection of compact mouth after accomplishing a sample reagent material loading, prevent that the internal sample reagent of jar from flowing out.

Drawings

The accompanying drawings, which form a part hereof, are included to provide a further understanding of the invention, and are incorporated in and constitute a part of this specification, illustrate embodiments of the invention and together with the description serve to explain the invention without undue limitation. In the drawings:

FIG. 1 is a schematic view of the entire loading apparatus;

FIG. 2 is a schematic view of a vertical plate;

FIG. 3 is a schematic view of a walking frame;

FIG. 4 is a cross-sectional view of the interior of the can body;

fig. 5 is an enlarged cross-sectional view of the interior of the tap.

Description of reference numerals:

1-a feeding station; 11-a feeding cylinder; 13-pressure head; 131-a bottom surface; 132-a top surface; 133-a connecting plate; 2-standing the plate; 21-a slot; 22-a slide; 23-supporting strips; 231-fracture; 3-a sample tank; 31-a feeding push rod; 311-pinch roller; 32-a tank body; 33-a discharge nozzle; 331-a sleeve; 332-a discharge pipe; 333-a feed port; 334-butting step; 335-a rubber sleeve; 336-flanging; 4-a walking frame; 41-a connecting rod; 5-a traveling electric cylinder; 6-a support plate; 61-through hole.

Detailed Description

It should be noted that, in the present invention, the embodiments and features of the embodiments may be combined with each other without conflict.

In the description of the present invention, it is to be understood that the terms "center", "longitudinal", "lateral", "up", "down", "front", "back", "left", "right", "vertical", "horizontal", "top", "bottom", "inner", "outer", and the like, indicate orientations or positional relationships based on the orientations or positional relationships shown in the drawings, and are used merely for convenience of description and for simplicity of description, and do not indicate or imply that the device or element being referred to must have a particular orientation, be constructed and operated in a particular orientation, and therefore, should not be construed as limiting the present invention. Furthermore, the terms "first", "second", etc. are used for descriptive purposes only and are not to be construed as indicating or implying relative importance or implicitly indicating the number of technical features indicated. Thus, a feature defined as "first," "second," etc. may explicitly or implicitly include one or more of that feature. In the description of the present invention, "a plurality" means two or more unless otherwise specified.

In the description of the present invention, it is to be noted that, unless otherwise explicitly specified or limited, the terms "mounted," "connected," and "connected" are to be construed broadly, and may be, for example, fixedly connected, detachably connected, or integrally connected; can be mechanically or electrically connected; they may be connected directly or indirectly through intervening media, or they may be interconnected between two elements. The specific meaning of the above terms in the present invention can be understood by those of ordinary skill in the art through specific situations.

The present invention will be described in detail below with reference to the accompanying drawings in conjunction with embodiments.

The utility model discloses a loading device of gene sequencer, including riser 2 and walking frame 4, riser 2 sets firmly slide 22 along the horizontal direction, walking frame 4 through the slider with slide 22 sliding connection, a plurality of sample jars 3 have set firmly on walking frame 4, every sample jar 3 all includes jar body 32, material loading push rod 31 and ejection of compact mouth 33, and every material loading push rod 31 can be connected with the piston rod of material loading cylinder 11 respectively;

a feeding station 1 is arranged on the vertical plate 2, and comprises a feeding cylinder 11 and a chip clamping seat (for the purpose of displaying the main content of the sample loading device by pictures, the chip clamping seat is not shown, and the specific structure of the chip clamping seat is the prior art in the field, which is not described herein again), which is arranged right below the feeding cylinder 11, the sample tank 3 is arranged between the feeding station 1 and the chip clamping seat, the sample tank 3 can move along the horizontal direction, and when a feeding push rod 31 of one sample tank 3 is connected with a piston rod of the feeding cylinder 11, a discharge nozzle 33 of the sample tank 3 is arranged right above the chip clamping seat;

a press head 13 is fixedly arranged at the bottom end of a piston rod of the feeding air cylinder 11, a press wheel 311 is arranged at the top of the feeding push rod 31, the press head 13 comprises a bottom surface 131 and a top surface 132, a connecting plate 133 is arranged between the bottom surface 131 and the top surface 132, the piston rod of the feeding air cylinder 11 is fixedly connected with the connecting plate 133, so that the press head 13 and the piston rod of the feeding air cylinder 11 move synchronously, a supporting bar 23 is arranged at the top of the vertical plate 2 along the horizontal direction, when the piston rod of the feeding air cylinder 11 is at the upper limit position, the upper surface of the supporting bar 23 and the bottom surface 131 of the press head 13 are in the same plane, the press wheel 311 moves on the supporting bar 23 along the length direction thereof, and the press wheel 311 of each sample tank 3 can be arranged between the bottom surface 131 and the top surface 132, when one of the press wheels 311 is arranged between the bottom surface 131 and the top surface 132, the press, specifically, a fracture 231 is formed in the middle of the supporting bar 23, and when the piston rod of the feeding cylinder 11 is at the upper limit position, the pressure head is located in the fracture 231.

Specifically, the walking frame 4 is arranged on a plate surface on one side of the vertical plate 2, a slotted hole 21 is formed in the vertical plate 2 in the horizontal reverse direction, a connecting rod 41 is fixedly arranged on the walking frame 4, the connecting rod 41 penetrates through the vertical plate 2 through the slotted hole 21, the end portion of the connecting rod 41 is connected with a walking electric cylinder 5, and the walking electric cylinder 5 is fixedly arranged on the plate surface on the other side of the vertical plate 2.

In order to plug the discharging nozzle 33 in time after the sample tank 3 finishes one feeding operation and prevent the sample reagent in the sample tank 3 from flowing out, the vertical plate 2 can move along the vertical direction, a supporting plate 612 is arranged above the chip clamping seat, the discharging nozzle 33 comprises a sleeve 331 communicated with the tank 32, the top end of the sleeve 331 is fixedly connected with the tank 32, a discharge pipe 332 capable of moving along the axial direction of the sleeve 331 is arranged in the sleeve 331, the top end of the discharge pipe 332 is closed, and a flange 336 extends outwards along the radial direction, the flange 336 can tightly abut against the end surface of the top end of the sleeve 331, the side wall of the top of the discharge pipe 332 is provided with a feed hole 333, the bottom of the discharge pipe 332 abuts against the step 334, the discharge pipe 332 is sleeved with a rubber sleeve 335, one end of the rubber sleeve 335 abuts against the bottom end of the sleeve 331, the other end of the rubber sleeve 335 abuts against the abutting step 334, and the elasticity of the rubber sleeve 335 is utilized to enable the flanging 336 at the top end of the discharge pipe 332 to tightly abut against the top end of the sleeve 331; the middle of the supporting plate 612 is provided with a through hole 61, the through hole 61 is arranged under the discharge pipe 332, when the vertical plate 2 moves downwards, the bottom end of the discharge pipe 332 of the sample tank 3 positioned at the feeding station 1 abuts against the supporting plate 612, the rubber sleeve 335 is continuously compressed, the discharge pipe 332 moves upwards relative to the sleeve 331, so that the feed hole 333 is opened, a sample reagent in the sample tank 3 can enter the discharge pipe 332 along the feed hole, meanwhile, a pipe orifice at the bottom end of the discharge pipe 332 is opposite to the through hole 61 of the supporting plate 612, so that the sample reagent can flow to a chip on the chip clamping seat through the through hole 61, and the reagent on the chip is detected through a gene sequencer.

Specifically, in order to move the vertical plate 2 up and down, slide rails are disposed on two sides of the vertical plate 2, and a sliding block and a cylinder (not shown in the figure) for supporting the vertical plate 2 may be disposed on a bracket for fixing the vertical plate 2, so that the vertical plate 2 moves up and down.

Specifically, the walking frame 4 or the chip clamping seat is provided with a washing tank, the chip is washed by the washing tank, and the function and the use method of the washing tank are the prior art and are not described again.

The utility model discloses a fast gene sequencer's sample loading device, in the course of the work, control walking electric jar 5 will need the sample reagent that detects to move to material loading station 1 on, later riser 2 descends, make discharging pipe 332 support on backup pad 612, make discharging pipe 332 and sample tank 3 communicate, later the piston rod of material loading jar 11 descends, make material loading push rod 31 push down the sample reagent, push out the sample reagent from discharging pipe 332, make the sample reagent flow to the chip of chip cassette, after accomplishing the material loading, the piston rod of material loading jar 11 drives material loading push rod 31 and rises to the initial position, make the sample reagent in the discharging pipe 332 flow into sample tank 3, later riser 2 upwards lifts up, under the effect of gum cover 335 elasticity and discharging pipe 332 gravity, discharging pipe 332 moves to the sample tank 3 outward, make the turn-ups 336 and the sleeve 331 top at discharging pipe 332 top separate the feed inlet of discharging pipe 332 with sample tank 3, the reagent in the sample tank 3 is prevented from flowing out.

The above description is only a preferred embodiment of the present invention, and should not be taken as limiting the invention, and any modifications, equivalent replacements, improvements, etc. made within the spirit and principle of the present invention should be included in the protection scope of the present invention.

Claims

1. A kind of loading attachment of the gene sequencer, characterized by that: comprises that

The feeding station (1) comprises a feeding cylinder (11) and a chip clamping seat arranged right below the feeding cylinder (11);

the device comprises a plurality of sample tanks (3) capable of moving along the horizontal direction synchronously, wherein each sample tank (3) comprises a tank body (32), a feeding push rod (31) and a discharge nozzle (33), each feeding push rod (31) can be connected with a piston rod of a feeding cylinder (11), and when the feeding push rod (31) of one sample tank (3) is connected with the piston rod of the feeding cylinder (11), the discharge nozzle (33) of the sample tank (3) is arranged right above a chip clamping seat;

the bottom end of a piston rod of the feeding cylinder (11) is fixedly provided with a pressure head (13), the top of the feeding push rod (31) is provided with a pressure wheel (311), the pressure head (13) comprises a bottom surface (131) and a top surface (132), the pressure wheel (311) can be arranged between the bottom surface (131) and the top surface (132), and when the pressure wheel (311) is arranged between the bottom surface (131) and the top surface (132), the pressure wheel (311) and the pressure head (13) can synchronously move along the vertical direction.

2. The loading device of a gene sequencer according to claim 1, wherein: still include riser (2) and walking frame (4), riser (2) have set firmly slide (22) along the horizontal direction, walking frame (4) pass through the slider with slide (22) are connected, sample jar (3) all set firmly on walking frame (4).

3. The loading device of a gene sequencer according to claim 1, wherein: a connecting plate (133) is arranged between the bottom surface (131) and the top surface (132), and a piston rod of the feeding cylinder (11) is fixedly connected with the connecting plate (133).

4. The loading device of a gene sequencer according to claim 2, wherein: a supporting bar (23) is arranged at the top of the vertical plate (2) along the horizontal direction, and the pressing wheel (311) is arranged above the supporting bar (23) and moves along the length direction of the supporting bar (23).

5. The loading device of gene sequencer according to claim 4, wherein: when the piston rod of the feeding cylinder (11) is at the upper limit position, the upper surface of the supporting bar (23) and the bottom surface (131) of the pressure head (13) are in the same plane.

6. The loading device of a gene sequencer according to claim 5, wherein: and a fracture (231) is formed in the middle of the supporting bar (23), and when the piston rod of the feeding cylinder (11) is at the upper limit position, the pressure head is arranged in the fracture (231).

7. The loading device of a gene sequencer according to claim 2, wherein: the vertical plate (2) is provided with a slotted hole (21) along the horizontal direction, the walking frame (4) is fixedly provided with a connecting rod (41), the connecting rod (41) penetrates through the vertical plate (2) through the slotted hole (21), and the end part of the connecting rod (41) is connected with a walking electric cylinder (5).

8. The loading device of a gene sequencer according to claim 7, wherein: the vertical plate (2) can move in the vertical direction, a supporting plate (6) is arranged above the chip clamping seat, the discharge nozzle (33) comprises a sleeve (331), the sleeve (331) is fixedly connected with the tank body (32), a discharge pipe (332) capable of moving axially along the sleeve (331) is arranged in the sleeve (331), the top end of the discharge pipe (332) is closed, the side wall of the top end of the discharge pipe is provided with a feed hole (333), the bottom of the discharge pipe (332) abuts against the step (334), a rubber sleeve (335) is sleeved on the discharge pipe (332), one end of the rubber sleeve (335) abuts against the bottom end of the sleeve (331), the other end of the rubber sleeve abuts against the step (334), a through hole (61) is formed in the middle of the supporting plate (6), and the through hole (61) is arranged under the discharge pipe (332).

9. The loading device of a gene sequencer according to claim 8, wherein: the top end of the discharge pipe (332) extends outwards to form a flange (336), and the flange (336) can tightly abut against the end face of the top end of the sleeve (331).