CN211586769U - Reducing mechanism is used in valaciclovir hydrochloride production - Google Patents
Reducing mechanism is used in valaciclovir hydrochloride production Download PDFInfo
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- CN211586769U CN211586769U CN201922350663.7U CN201922350663U CN211586769U CN 211586769 U CN211586769 U CN 211586769U CN 201922350663 U CN201922350663 U CN 201922350663U CN 211586769 U CN211586769 U CN 211586769U
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Abstract
The crushing device for valaciclovir hydrochloride production comprises a main box body, wherein the top of the main box body is provided with a feed hopper, and a first horizontal plate and a second horizontal plate are arranged in the main box body; the first horizontal plate is provided with a circular truncated cone body capable of rotating around a central shaft of the first horizontal plate, and the outer wall of the circular truncated cone body and the inner wall of the crushing bin are both provided with threaded bulges; a vertical rotating shaft is arranged on the second horizontal plate, the upper end of the vertical rotating shaft penetrates through the first horizontal plate and is fixedly connected with the bottom surface of the circular truncated cone, a scraping plate is arranged on the vertical rotating shaft and is in contact with the top surface of the second horizontal plate, and a plurality of blanking holes are formed in the second horizontal plate; a horizontal air inlet pipe is arranged in the main box body below the second horizontal plate, and one end of the air inlet pipe penetrates through the side wall of the main box body and is connected with a nitrogen tank. Adopt above-mentioned structure, through the crushing operation of the cubic material of carrying out the midbody in the sealed environment, avoided the production of dust, carry out the drying after smashing through heating nitrogen gas simultaneously, can avoid the product oxidation under the prerequisite that reaches the dry purpose.
Description
Technical Field
The utility model relates to a valaciclovir hydrochloride production field, it is specific that reducing mechanism is used in valaciclovir hydrochloride production.
Background
Valacyclovir hydrochloride is L-valine acid ester of acyclovir, is a prodrug of acyclovir, and is mainly used for treating herpes zoster and simple herpes virus infection of skin mucosa. In the production of valacyclovir hydrochloride, the synthesized valacyclovir intermediate is agglomerated after organic solvent is removed by a centrifugal machine, and generally needs to be crushed by a crusher for subsequent processes in production, so that equivalent dust can be generated in the crushing process, the working environment can be polluted, and raw material waste can be caused.
Disclosure of Invention
The utility model aims to solve the technical problem that a reducing mechanism is used in valaciclovir hydrochloride production is provided, its crushing operation through the cubic material that carries out the midbody in the sealed environment has avoided the production of dust, carries out the drying after smashing through heating nitrogen gas simultaneously, can avoid the product oxidation under the prerequisite that reaches dry purpose.
In order to solve the technical problem, the utility model discloses the technical scheme who adopts is: the crushing device for valaciclovir hydrochloride production comprises a main box body, wherein the top of the main box body is provided with a feed hopper, a first horizontal plate and a second horizontal plate are arranged in the main box body, the inner area of the main box body above the first horizontal plate is a crushing bin, and the inner area of the main box body between the first horizontal plate and the second horizontal plate is a drying bin;
the first horizontal plate is provided with a circular truncated cone body capable of rotating around a central shaft of the first horizontal plate, and the outer wall of the circular truncated cone body and the inner wall of the crushing bin are both provided with threaded bulges;
the second horizontal plate is provided with a vertical rotating shaft, the upper end of the vertical rotating shaft penetrates through the first horizontal plate and is fixedly connected with the bottom surface of the circular truncated cone, the vertical rotating shaft is provided with a scraper, the scraper is in contact with the top surface of the second horizontal plate, and the second horizontal plate is provided with a plurality of blanking holes;
and a horizontal air inlet pipe is arranged in the main box body below the second horizontal plate, and one end of the air inlet pipe penetrates through the side wall of the main box body and is connected with a nitrogen tank.
In the preferred scheme, the bottom of the round table body is provided with a convex block, the top surface of the first horizontal plate is provided with a groove, and the convex block is arranged in the groove to realize the fixation of the round table body.
In the preferred scheme, the side wall of the first horizontal plate is symmetrically provided with at least two connecting blocks, the connecting blocks are fixedly connected with the inner side wall of the main box body, and strip-shaped holes are formed between the side wall of the first horizontal plate and the inner side wall of the main box body.
In the preferred scheme, the top surface of the circular truncated cone body is provided with a driven bevel gear, the outer wall of the main box body is provided with a motor, a horizontal rotating shaft penetrates through the side wall of the main box body above the motor, the motor is in transmission connection with one end of the horizontal rotating shaft through a gear pair, and the other end of the horizontal rotating shaft is provided with a driving bevel gear meshed with the driven bevel gear.
In the preferred scheme, the part of the air inlet pipe in the main box body is provided with a plurality of downward air inlets, the top of the air inlet pipe is also provided with an L-shaped batten, and the cross section of the L-shaped batten is arranged above the air inlet pipe in a roof shape.
In the preferred scheme, the part of the air inlet pipe, which is positioned outside the main box body, is provided with a plate heat exchanger, and the position of the air inlet pipe, which is close to the nitrogen tank, is also provided with an air valve.
In the preferable scheme, the side wall of the drying bin is provided with an air outlet pipe, the air outlet pipe is connected to the water treatment tank and extends below the liquid level of cleaning water in the water treatment tank, and the top of the water treatment tank is also provided with a nitrogen recovery pipe.
In the preferred scheme, the inner bottom surface of the main box body is an inclined surface, one side of the main box body, which is penetrated by the air inlet pipe, is inclined downwards, and the outer side wall of the main box body at the lower end of the inner bottom surface is provided with a chute.
The utility model provides a reducing mechanism is used in valaciclovir hydrochloride production through adopting above-mentioned structure, has following beneficial effect:
(1) the crushing aim of the blocky materials with different sizes is realized by the change of the distance between the circular table body and the side wall of the box body, and the crushing effect is ensured;
(2) the whole crushing process is carried out in a sealed environment, so that the generation of dust and the waste of raw materials are avoided;
(3) the materials are dried after being crushed by heating nitrogen, so that the oxidation of the materials can be avoided;
(4) the heated nitrogen can be recycled.
Drawings
The invention will be further explained with reference to the following figures and examples:
fig. 1 is a schematic view of the overall overlooking structure of the present invention.
Fig. 2 is a schematic diagram of a first horizontal plate structure of the present invention.
Fig. 3 is a schematic diagram of a first horizontal plate structure of the present invention.
Fig. 4 is a schematic view of the cross-sectional structure of the intake pipe of the present invention.
In the figure: the device comprises a main box body 1, a crushing bin 101, a drying bin 102, a feeding hopper 2, a round table body 3, a bump 301, a first horizontal plate 4, a groove 401, a connecting block 402, a driven bevel gear 5, a motor 6, a horizontal rotating shaft 7, a gear pair 8, a driving bevel gear 9, a vertical rotating shaft 10, a second horizontal plate 11, a blanking hole 111, a scraper 12, an air inlet pipe 13, an air inlet 131, an 'L' -shaped slat 132, a nitrogen tank 14, an air valve 141, a plate heat exchanger 15, an air outlet pipe 16, a water treatment box 17, a nitrogen recovery pipe 18 and a chute 19.
Detailed Description
Example 1:
as shown in fig. 1-4, the crushing device for valacyclovir hydrochloride production comprises a main box body 1, wherein a feed hopper 2 is arranged at the top of the main box body 1, a first horizontal plate 4 and a second horizontal plate 11 are arranged in the main box body 1, the inner area of the main box body 1 above the first horizontal plate 4 is a crushing bin 101, and the inner area of the main box body 1 between the first horizontal plate 4 and the second horizontal plate 11 is a drying bin 102;
the first horizontal plate 4 is provided with a circular truncated cone 3 which can rotate around a central shaft of the first horizontal plate, and the outer wall of the circular truncated cone 3 and the inner wall of the crushing bin 101 are both provided with thread protrusions;
a vertical rotating shaft 10 is arranged on the second horizontal plate 11, the upper end of the vertical rotating shaft 10 penetrates through the first horizontal plate 4 and is fixedly connected with the bottom surface of the circular truncated cone 3, a scraping plate 12 is arranged on the vertical rotating shaft 10, the scraping plate 12 is in contact with the top surface of the second horizontal plate 11, and a plurality of blanking holes 111 are formed in the second horizontal plate 11;
a horizontal air inlet pipe 13 is arranged in the main box body 1 below the second horizontal plate 11, and one end of the air inlet pipe 13 penetrates through the side wall of the main box body 1 and is connected with a nitrogen tank 14.
In a preferable scheme, a bump 301 is arranged at the bottom of the circular truncated cone 3, a groove 401 is arranged on the top surface of the first horizontal plate 4, and the bump 301 is arranged in the groove 401 to fix the circular truncated cone 3.
In a preferable scheme, at least two connecting blocks 402 are symmetrically arranged on the side wall of the first horizontal plate 4, the connecting blocks 402 are fixedly connected with the inner side wall of the main box body 1, and a strip-shaped opening is formed between the side wall of the first horizontal plate 4 and the inner side wall of the main box body 1.
In the preferred scheme, the top surface of the round table body 3 is provided with a driven bevel gear 5, the outer wall of the main box body 1 is provided with a motor 6, the side wall of the main box body 1 above the motor 6 is provided with a horizontal rotating shaft 7 in a penetrating way, the motor 6 is in transmission connection with one end of the horizontal rotating shaft 7 through a gear pair 8, and the other end of the horizontal rotating shaft 7 is provided with a driving bevel gear 9 meshed with the driven bevel gear 5.
In a preferred embodiment, a plurality of downward air inlets 131 are disposed on a portion of the air inlet pipe 13 located in the main box 1, an "L" shaped slat 132 is further disposed on a top of the air inlet pipe 13, and a cross section of the "L" shaped slat 132 is disposed above the air inlet pipe 13 in a roof shape.
In a preferable scheme, a plate heat exchanger 15 is arranged on the part of the air inlet pipe 13 outside the main box body 1, and an air valve 141 is further arranged on the position of the air inlet pipe 13 close to the nitrogen tank 14.
In a preferable scheme, an air outlet pipe 16 is arranged on the side wall of the drying bin 102, the air outlet pipe 16 is connected to the water treatment tank 17 and extends below the cleaning water level in the water treatment tank 17, and a nitrogen recovery pipe 18 is further arranged at the top of the water treatment tank 17.
In the preferred scheme, the inner bottom surface of the main box body 1 is an inclined surface, one side of the main box body 1 penetrated by the air inlet pipe 13 inclines downwards to the opposite side, and the outer side wall of the main box body 1 at the lower end of the inner bottom surface is provided with a chute 19
In the preferred scheme, the inner bottom surface of the main box body 1 can be coated with a polytetrafluoroethylene coating, so that the materials can move to the lower end after falling down, and the accumulation on the inner bottom surface is avoided.
Example 2:
the principle of the device is as follows:
putting the agglomerated intermediate material into a main box body 1 from a feed hopper 2, enabling the material to fall into a gap between a round table body 3 and the inner wall of the main box body 1, starting a motor 6, driving the round table body 3 to rotate by the motor 6, enabling the massive material to fall after being gradually crushed and continuously reduced by matching with a thread bulge on the outer wall of the round table body 3 until the massive material is completely crushed into powder, enabling the material to fall on a second horizontal plate 11 after passing through a strip-shaped gap between the side wall of a first horizontal plate 4 and the main box body 1, enabling the material to spread by a scraper 12 on a vertical rotating shaft 10 and the scraper 12 on the vertical rotating shaft 10 to rotate together, enabling the material to pass through a discharging hole 111 and fall after being contacted with heated input nitrogen, completing drying, enabling the material to fall on the inner bottom surface of the main box body 1, then accumulating at the lower end of the inner bottom surface along the inclination direction of the inner bottom surface, and completing, the discharge door is opened and the material is discharged from the chute 19.
By adopting the structure, the utility model realizes the crushing purpose of the block materials with different sizes by the change of the space between the round platform body and the side wall of the box body, and ensures the crushing effect; the whole crushing process is carried out in a sealed environment, so that the generation of dust and the waste of raw materials are avoided; the materials are dried after being crushed by heating nitrogen, so that the oxidation of the materials can be avoided; the heated nitrogen can be recycled.
Claims (8)
1. Reducing mechanism is used in valaciclovir hydrochloride production, including main tank body (1), main tank body (1) top is equipped with feeder hopper (2), characterized by: a first horizontal plate (4) and a second horizontal plate (11) are arranged in the main box body (1), the inner area of the main box body (1) above the first horizontal plate (4) is a crushing bin (101), and the inner area of the main box body (1) between the first horizontal plate (4) and the second horizontal plate (11) is a drying bin (102);
the first horizontal plate (4) is provided with a circular truncated cone body (3) capable of rotating around a central shaft of the first horizontal plate, and the outer wall of the circular truncated cone body (3) and the inner wall of the crushing bin (101) are provided with thread protrusions;
a vertical rotating shaft (10) is arranged on the second horizontal plate (11), the upper end of the vertical rotating shaft (10) penetrates through the first horizontal plate (4) and is fixedly connected with the bottom surface of the circular truncated cone body (3), a scraping plate (12) is arranged on the vertical rotating shaft (10), the scraping plate (12) is in contact with the top surface of the second horizontal plate (11), and a plurality of blanking holes (111) are formed in the second horizontal plate (11);
the main tank body (1) below the second horizontal plate (11) is internally provided with a horizontal air inlet pipe (13), and one end of the air inlet pipe (13) penetrates through the side wall of the main tank body (1) and is connected with a nitrogen tank (14).
2. The crushing device for valacyclovir hydrochloride production according to claim 1, wherein: the bottom of the round table body (3) is provided with a convex block (301), the top surface of the first horizontal plate (4) is provided with a groove (401), and the convex block (301) is arranged in the groove (401) to realize the fixation of the round table body (3).
3. The comminution device of claim 2 for valacyclovir hydrochloride production, characterized in that: the side wall of the first horizontal plate (4) is symmetrically provided with at least two connecting blocks (402), the connecting blocks (402) are fixedly connected with the inner side wall of the main box body (1), and strip-shaped holes are formed between the side wall of the first horizontal plate (4) and the inner side wall of the main box body (1).
4. The crushing device for valacyclovir hydrochloride production according to claim 1, wherein: the top surface of the round table body (3) is provided with a driven bevel gear (5), the outer wall of the main box body (1) is provided with a motor (6), a horizontal rotating shaft (7) penetrates through the side wall of the main box body (1) above the motor (6), the motor (6) is in transmission connection with one end of the horizontal rotating shaft (7) through a gear pair (8), and the other end of the horizontal rotating shaft (7) is provided with a driving bevel gear (9) meshed with the driven bevel gear (5).
5. The crushing device for valacyclovir hydrochloride production according to claim 1, wherein: the air inlet pipe (13) is provided with a plurality of downward air inlets (131) on the part positioned in the main box body (1), the top of the air inlet pipe (13) is also provided with an L-shaped slat (132), and the cross section of the L-shaped slat (132) is arranged above the air inlet pipe (13) in a roof shape.
6. The crushing device for valacyclovir hydrochloride production according to claim 1, wherein: the part of the air inlet pipe (13) outside the main box body (1) is provided with a plate type heat exchanger (15), and the position of the air inlet pipe (13) close to the nitrogen tank (14) is also provided with an air valve (141).
7. The crushing device for valacyclovir hydrochloride production according to claim 1, wherein: an air outlet pipe (16) is arranged on the side wall of the drying bin (102), the air outlet pipe (16) is connected to the water treatment tank (17) and extends into the water treatment tank (17) below the liquid level of cleaning water, and a nitrogen recovery pipe (18) is further arranged at the top of the water treatment tank (17).
8. The crushing device for valacyclovir hydrochloride production according to claim 1, wherein: the inner bottom surface of the main box body (1) is an inclined surface, one side of the main box body (1) which is penetrated by the air inlet pipe (13) inclines downwards to the opposite side, and the outer side wall of the main box body (1) at the lower end of the inner bottom surface is provided with a chute (19).
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201922350663.7U CN211586769U (en) | 2019-12-24 | 2019-12-24 | Reducing mechanism is used in valaciclovir hydrochloride production |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201922350663.7U CN211586769U (en) | 2019-12-24 | 2019-12-24 | Reducing mechanism is used in valaciclovir hydrochloride production |
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| CN211586769U true CN211586769U (en) | 2020-09-29 |
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| CN201922350663.7U Active CN211586769U (en) | 2019-12-24 | 2019-12-24 | Reducing mechanism is used in valaciclovir hydrochloride production |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN114586842A (en) * | 2022-03-03 | 2022-06-07 | 安徽达诺乳业股份有限公司 | Tubular sterilizer for condensed milk production |
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2019
- 2019-12-24 CN CN201922350663.7U patent/CN211586769U/en active Active
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN114586842A (en) * | 2022-03-03 | 2022-06-07 | 安徽达诺乳业股份有限公司 | Tubular sterilizer for condensed milk production |
| CN114586842B (en) * | 2022-03-03 | 2023-09-22 | 安徽达诺乳业股份有限公司 | Tubular sterilizer for condensed milk production |
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