CN211584875U

CN211584875U - Transdermal drug delivery electronic plaster based on radio frequency radiator

Info

Publication number: CN211584875U
Application number: CN201922000301.5U
Authority: CN
Inventors: 景志强; 葛路平
Original assignee: Nanjing Congjing Biotechnology Co ltd
Current assignee: Nanjing Congjing Biotechnology Co ltd
Priority date: 2019-11-19
Filing date: 2019-11-19
Publication date: 2020-09-29
Anticipated expiration: 2029-11-19

Abstract

The utility model discloses a percutaneous electronic subsides of dosing based on radio frequency radiator contains four-layer structure, from last down be non-woven fabrics, irradiator, waterproof layer and medicine oil reservoir in proper order, the non-woven fabrics is laid on the irradiator, be equipped with the connection riveting on the irradiator, connect the riveting and pass the non-woven fabrics can with radio frequency transmission line lock joint, be equipped with the waterproof layer below the irradiator, be the medicine oil reservoir below the waterproof layer, the medicine oil reservoir directly laminates mutually with human epidermis. The utility model discloses utilize the produced electromagnetic field of radio frequency radiation and the heating effect when human body absorbs radio frequency energy, accelerate the percutaneous infiltration of medicine, promote the human absorption to the medicine to reach and improve the effect of using medicine.

Description

Transdermal drug delivery electronic plaster based on radio frequency radiator

Technical Field

The utility model relates to a radio frequency medical treatment technical field specifically is a percutaneous electronic paste of dosing based on radio frequency radiator.

Background

At present, oral administration and injection administration are the two most commonly used administration methods, but both the two administration methods have respective defects, and the oral administration is inevitably influenced by various enzymes in a digestive system, gastrointestinal acid-base environment, liver first-pass effect and the like, so that the bioavailability of the medicine is low, and patients with serious diseases such as coma and the like are difficult to take the medicine; the injection administration causes tissue damage and pain, has potential complications and adverse reactions, and causes muscle stiffness and atrophy at the injection site after long-term injection. The transdermal drug delivery is a novel drug delivery means relative to the conventional drug delivery methods such as oral administration, injection and the like, and the mode of transdermal drug delivery does not cause tissue damage and pain, can improve the compliance of patients, simultaneously avoids the influence of various enzymes in the digestive system and the acid-base environment of intestines and stomach and the first pass effect of liver, can maintain constant blood concentration, and has positive effects on relieving the pain of the patients and improving the bioavailability of the drug. Because of the advantages of transdermal drug delivery and the continuous development of transdermal technology, transdermal drug delivery is now one of the fastest growing pharmaceutical industries, and the annual composite growth rate is expected to exceed 12% in the cardiovascular field with the fastest market growth according to the latest report of grandView Research corporation, and the global transdermal drug delivery system market is expected to reach $ 814 billion by 2024.

Transdermal drug delivery has many advantages, but has limitations, because the transdermal drug delivery route is the penetration of the drug into the capillary vessels and into the human body circulation after penetrating the skin, and the main problem facing transdermal drug delivery is the skin barrier effect. The skin physiological factors affecting the percutaneous absorption of drugs mainly include conditions such as skin hydration, skin stratum corneum thickness, skin damage, and temperature. Good skin hydration, thin stratum corneum, damaged stratum corneum, high skin temperature, etc. can facilitate transdermal penetration of drugs. Studies have shown that the transdermal rate and amount of penetration of a drug are difficult to meet therapeutic requirements if it relies solely on the natural penetration of the drug, and in order to promote transdermal absorption of the drug, certain permeation-promoting techniques must be used to overcome the barrier limitations of the skin to increase the permeability of the drug to the skin.

SUMMERY OF THE UTILITY MODEL

Technical problem to be solved

To the barrier restriction effect of skin in transdermal administration, the utility model provides a transdermal electron subsides of dosing based on radio frequency radiator to radio frequency radiation's electromagnetic field and heat effect improve the permeability of skin, improve the permeability of medicine to the skin, thereby promote the human absorption to the medicine, strengthen the curative effect of medicine.

(II) technical scheme

In order to achieve the above object, the utility model provides a following technical scheme: the utility model provides a percutaneous electronic subsides of dosing based on radio frequency radiator contains four-layer structure, down is non-woven fabrics, irradiator, waterproof layer and medicine oil layer from last in proper order, the non-woven fabrics is laid on the irradiator, be equipped with the connection riveting on the irradiator, the connection riveting passes the non-woven fabrics and is connected with the radio frequency transmission line, be equipped with the waterproof layer below the irradiator, be the medicine oil layer below the waterproof layer, the medicine oil layer directly laminates mutually with human epidermis.

As an optimal technical scheme of the utility model, the non-woven fabrics is located the superiors of electronic subsides, and for rectangular fillet medical non-woven fabrics, thickness is 0.2mm, and length is 120mm, and is wide for 90 mm.

As an optimal technical scheme of the utility model, the central part of irradiator between non-woven fabrics and waterproof layer, for a set of dipole antenna that two axisymmetric the same U-shaped copper foils constitute, two copper foil thickness are 0.05mm, at a distance of 6mm between, wide 30mm, long 19.5 mm.

As an optimal technical scheme of the utility model, connect the riveting and be ∅ 3.5.5 mm metal pin thread, the bottom is riveted in the copper foil central authorities of irradiator, connects riveting and is connected with the transmission line, and the electromagnetic wave that the radio frequency power source sent transmits the irradiator through the transmission line.

As an optimized technical scheme of the utility model, the waterproof layer is 0.2 mm's pearly-lustre membrane for one deck thickness between irradiator and medicine oil blanket, and the shape is the same with the non-woven fabrics, and the size is big and be less than the non-woven fabrics than the irradiator.

As an optimal technical scheme of the utility model, the medicament of oil medicine layer under the waterproof layer glues glutinous layer for the medicament according to the preparation, contacts with human epidermis.

(III) advantageous effects

Compared with the prior art, the utility model provides a percutaneous electronic paste of dosing based on radio frequency radiator, with radio frequency radiator and medicament integration on a slice medicine subsides, it possesses following beneficial effect:

1. radio frequency electromagnetic waves are transmitted to skin tissues of a human body in a radiation mode, and micro-current is generated due to electrostatic effect and acts on skin horny layers, so that the structure of the skin horny layers is changed to generate new micro-channels, and the medicine can enter the skin through the micro-channels; meanwhile, the electromagnetic field generated by radiation can change the physicochemical property of the horny layer of the skin, transfer the tissue moisture and improve the permeability of the epidermis.

2. The skin receives radio frequency energy to raise the temperature, so that the structure of the stratum corneum is changed, new water channels are generated in the stratum corneum of the skin, and the permeability of the drug is increased.

3. The utility model discloses supporting power supply is portable chargeable radio frequency power supply, and is small, suitably carries, facilitates the use, does benefit to the popularization.

Drawings

FIG. 1 is a front view of the present invention;

FIG. 2 is an internal view of the present invention;

fig. 3 is a schematic view of the layered structure of the present invention.

In the figure: 1. non-woven fabrics; 2. connecting a rivet buckle; 3. a radiator; 4. a waterproof layer; 5. a medicinal oil layer; 6. a transmission line.

Detailed Description

The technical solutions in the embodiments of the present invention will be described clearly and completely with reference to the accompanying drawings in the embodiments of the present invention, and it is obvious that the described embodiments are only some embodiments of the present invention, not all embodiments. Based on the embodiments in the present invention, all other embodiments obtained by a person skilled in the art without creative work belong to the protection scope of the present invention.

Examples

Referring to fig. 1-3, the present invention provides the following technical solutions: the utility model provides a percutaneous electronic subsides of dosing based on radio frequency radiator, contains four-layer structure, from last non-woven fabrics 1, irradiator 3, waterproof layer 4 and the medicine oil layer 5 of down being in proper order, non-woven fabrics 1 is laid on irradiator 3, is equipped with on the irradiator 3 and connects the riveting 2, connects riveting 2 and passes non-woven fabrics 1 and be connected with radio frequency transmission line 6, is equipped with waterproof layer 4 below the irradiator 3, is medicine oil layer 5 below the waterproof layer 4, medicine oil layer 5 directly laminates mutually with the human epidermis.

Specifically, the non-woven fabric 1 is located on the uppermost layer of the electronic sticker, is a rectangular rounded medical non-woven fabric, and has a thickness of 0.2mm, a length of 120mm and a width of 90 mm.

Specifically, the radiator 3 is a group of dipole antennas formed by two axisymmetric identical U-shaped copper foils at the central part between the non-woven fabric 1 and the waterproof layer 4, the two copper foils are 0.05mm thick, 6mm apart, 30mm wide and 19.5mm long.

Specifically, the connecting rivet 2 is a metal male snap with a thickness of ∅ 3.5.5 mm, the bottom of the connecting rivet is riveted at the center of the copper foil of the radiator 3, the connecting rivet 2 is connected with the transmission line 6, and the electromagnetic wave emitted by the radio frequency power source is transmitted to the radiator 3 through the transmission line 6.

Specifically, the waterproof layer 4 is a pearlized film with a thickness of 0.2mm between the radiator 3 and the medicinal oil layer 5, and has the same shape as the non-woven fabric 1, and the size of the pearlized film is larger than that of the radiator 3 and smaller than that of the non-woven fabric 1.

Specifically, the lowest layer of the medicinal oil layer 5 below the waterproof layer 4 is a medicament adhesive layer prepared according to a formula and is in contact with the epidermis of a human body.

The utility model discloses an use flow and theory of operation: firstly, two connecting rivets 2 are connected with two female buttons on a transmission line 6, the other end of the transmission line 6 is connected with a radio frequency power source, then a protective film on a medicine oil layer 5 is removed and is attached to a treatment part of a human body, and finally the radio frequency power source is started. The radio frequency power source generates radio frequency electromagnetic waves, which are transmitted to the radiator 3 through the transmission line 6 and then radiated to the human body tissue by the radiator 3.

Finally, it should be noted that: although the present invention has been described in detail with reference to the foregoing embodiments, it will be apparent to those skilled in the art that modifications may be made to the embodiments described above, or some features may be substituted in the embodiments. Any modification, equivalent replacement, or improvement made within the spirit and principle of the present invention should be included in the protection scope of the present invention.

Claims

1. A transdermal drug delivery electronic plaster based on a radio frequency radiator is characterized in that: contain the quadruple layer structure, down be non-woven fabrics (1), irradiator (3), waterproof layer (4) and medicine oil layer (5) from last in proper order, non-woven fabrics (1) are laid on irradiator (3), be equipped with on irradiator (3) and connect riveting (2), it passes non-woven fabrics (1) and is connected with radio frequency transmission line (6) to connect riveting (2), be equipped with waterproof layer (4) below irradiator (3), be medicine oil layer (5) below waterproof layer (4), medicine oil layer (5) directly laminate mutually with human epidermis.

2. The transdermal drug delivery electronic plaster based on the radio frequency radiator as claimed in claim 1, characterized in that: the non-woven fabric (1) is located on the uppermost layer of the electronic sticker, is rectangular rounded medical non-woven fabric, is 0.2mm thick, 120mm long and 90mm wide.

3. The transdermal drug delivery electronic plaster based on the radio frequency radiator as claimed in claim 1, characterized in that: the radiator (3) is a group of dipole antennas formed by two axisymmetric same U-shaped copper foils at the central part between the non-woven fabric (1) and the waterproof layer (4), the thickness of the two copper foils is 0.05mm, the distance between the two copper foils is 6mm, the width is 30mm, and the length is 19.5 mm.

4. The transdermal drug delivery electronic plaster based on the radio frequency radiator as claimed in claim 1, characterized in that: the connecting rivet button (2) is a metal male button of ∅ 3.5.5 mm, the bottom of the connecting rivet button is riveted at the center of the copper foil of the radiator (3), the connecting rivet button (2) is connected with the transmission line (6), and the electromagnetic wave emitted by the radio frequency power source is transmitted to the radiator (3) through the transmission line (6).

5. The transdermal drug delivery electronic plaster based on the radio frequency radiator as claimed in claim 1, characterized in that: the waterproof layer (4) is arranged between the radiator (3) and the medicine oil layer (5), is a pearlized film with the thickness of 0.2mm, has the same shape as the non-woven fabric (1), and is larger than the radiator (3) and smaller than the non-woven fabric (1).

6. The transdermal drug delivery electronic plaster based on the radio frequency radiator as claimed in claim 1, characterized in that: the lowest layer of the oil layer (5) below the waterproof layer (4) is a medicament adhesive layer prepared according to a formula and is in contact with the epidermis of a human body.