CN211553514U

CN211553514U - Mixing device of magnetic bead reagent and sample analysis equipment

Info

Publication number: CN211553514U
Application number: CN201920548901.2U
Authority: CN
Inventors: 徐文博; 翁彦雯; 王俊
Original assignee: Shenzhen Mindray Bio Medical Electronics Co Ltd
Current assignee: Shenzhen Mindray Bio Medical Electronics Co Ltd
Priority date: 2019-04-22
Filing date: 2019-04-22
Publication date: 2020-09-22
Anticipated expiration: 2029-04-22
Also published as: CN214374842U

Abstract

The application discloses mixing device and sample analysis equipment of magnetic bead reagent, this mixing device include that magnetism spare, reagent container deposit mechanism and actuating mechanism, and reagent container deposits the mechanism and has at least one installation department for the installation is deposited the magnetic bead liquid container that remains the mixing magnetic bead reagent, and the installation department corresponds the setting of magnetism spare, makes the magnetic bead liquid container that is located on the installation department can be in the magnetic field. The driving mechanism is provided with a driving structure which can drive at least one of the magnetic piece, the mounting part and the magnetic bead liquid container to move and enables the magnetic bead liquid container to generate movement relative to the magnetic field. Through the relative motion between magnetic bead reagent and magnetic field, change the direction that magnetic force acted on the magnetic bead for the magnetic bead flows along each different direction under the magnetic force effect, reaches the purpose of mixing, need not the manual mixing of user, has promoted the efficiency of mixing magnetic bead reagent greatly.

Description

Mixing device of magnetic bead reagent and sample analysis equipment

Technical Field

The application relates to the technical field of medical equipment, in particular to a mixing device of a magnetic bead reagent and sample analysis equipment.

Background

Magnetic bead reagents are widely used in the field of sample analysis, such as chemiluminescent immunoassays for heterogeneous separations. The magnetic bead reagent usually comprises magnetic beads, a label thereof and a buffer solution, and when in use, the magnetic bead reagent is sucked by a corresponding reagent sucking device and is sent to a corresponding reaction container. Because the magnetic bead reagent itself takes place the deposit easily and hardens when the storage is placed, consequently, need fully mix the magnetic bead reagent before drawing the magnetic bead reagent to this accuracy of guaranteeing the test result. In particular, the concentration of magnetic beads in the currently used magnetic bead reagent is continuously increased because the high concentration of magnetic beads contributes to the repeatability of the test result, and the higher the concentration of magnetic beads is, the more serious the deposition effect is.

In order to eliminate the problem of magnetic bead deposition, some test equipment manufacturers require a user to mix a magnetic bead reagent manually before loading the reagent, but the manual mixing efficiency is low, time and labor are wasted, and particularly for high-concentration magnetic beads marked with streptavidin, the manual mixing is difficult to realize, so that the working efficiency of the user is seriously influenced. And other manufacturers can directly stir and mix the magnetic bead reagent in the magnetic bead cavity, or mix the magnetic beads by adopting mechanical rotation or an ultrasonic system, but the manufacturers have corresponding disadvantages. Therefore, the mixing scheme for the magnetic bead reagent needs further research.

SUMMERY OF THE UTILITY MODEL

The application provides a novel mixing device of magnetic bead reagent and sample analysis equipment.

An embodiment of the application provides a mixing device of magnetic bead reagent, includes:

a magnetic member for generating a magnetic field;

the reagent container storage mechanism is provided with at least one mounting part and is used for mounting a magnetic bead liquid container for storing a magnetic bead reagent to be uniformly mixed, and the mounting part is arranged corresponding to the magnetic part so that the magnetic bead liquid container positioned on the mounting part can be positioned in the magnetic field;

and the driving mechanism is provided with a driving structure which can drive at least one of the magnetic piece, the mounting part and the magnetic bead liquid container to move and enables the magnetic bead liquid container to generate movement relative to the magnetic field.

In one embodiment, the mounting portion has a configuration capable of defining a longitudinally extending arrangement of beads along a first axis, and the magnetic member has a south pole or a north pole disposed at a non-zero angle with respect to the first axis.

In one embodiment, the south pole or the north pole of the magnetic member is oriented perpendicularly to the first axis.

In one embodiment, the driving mechanism comprises a first driving assembly capable of driving the magnetic bead solution container to rotate in forward direction and reverse direction alternately.

In one embodiment, the reagent container storage mechanism comprises an annular base, the number of the installation parts is at least two, the installation parts are arranged on the annular base along an arc or a circle, and the magnetic part is located at the middle hole position of the annular base.

In one embodiment, first drive assembly includes first toothed disc, with annular base sets up with the axle center and fixed connection's second toothed disc and drive second toothed disc pivoted motor, first toothed disc is fixed to be set up and is located annular base's middle hole site department, the teeth of a cogwheel of first toothed disc stretches into in the magnetic bead liquid container mounting region who corresponds the installation department, so that make the teeth of a cogwheel of first toothed disc can mesh with the gear on the magnetic bead liquid container mutually, drive the rotation of magnetic bead liquid container.

In one embodiment, first drive assembly includes first gear dish and the first gear dish pivoted motor of drive, first gear dish sets up annular base's middle hole site department, the teeth of a cogwheel of first gear dish stretches into in the magnetic bead liquid container mounting area who corresponds the installation department, so that make the teeth of a cogwheel of first gear dish can mesh with the gear on the magnetic bead liquid container mutually.

In one embodiment, the number of the magnetic members is at least two, and the magnetic members are fixedly arranged on the first gear plate along an arc shape or a circular shape.

In one embodiment, the magnetic members are consistent with the mounting portions in number, and each magnetic member is arranged corresponding to one mounting portion, so that the magnetic bead liquid container on the mounting portion can be positioned in the magnetic field of the corresponding magnetic member.

In one embodiment, the drive mechanism comprises a second drive assembly having an output in driving connection with the reagent container storage mechanism to drive the mounting portion to rotate about the magnetic member.

This application provides in an embodiment another kind of magnetic bead reagent's mixing device, includes:

a magnetic member for generating a magnetic field;

a reagent container storage mechanism having at least one mounting portion;

the magnetic bead liquid container is used for storing a magnetic bead reagent to be uniformly mixed, is arranged on the mounting part and is positioned in a magnetic field generated by the magnetic part;

and the driving mechanism is in transmission connection with at least one of the magnetic part, the mounting part and the magnetic bead liquid container so as to drive the magnetic bead liquid container to move relative to the magnetic field.

In one embodiment, the south pole or the north pole of the magnetic member is disposed toward the side wall of the chamber of the magnetic bead liquid container.

In one embodiment, the south pole or the north pole of the magnetic member is vertically oriented to the side wall of the chamber of the magnetic bead liquid container.

In one embodiment, the first driving assembly comprises a first gear disc, a second gear disc which is coaxially arranged with the annular base and fixedly connected with the annular base, and a motor for driving the second gear disc to rotate, the first gear disc is fixedly arranged and located at the middle hole position of the annular base, a gear which is coaxially arranged with the magnetic bead liquid container is installed on the magnetic bead liquid container, and the gear teeth of the first gear disc are meshed with the gear on the magnetic bead liquid container to drive the magnetic bead liquid container to rotate.

In one embodiment, the first driving assembly comprises a first gear disc and a motor for driving the first gear disc to rotate, the mounting portion is arranged around the first gear disc along an arc shape or a circular shape, the magnetic bead liquid container is provided with a gear coaxially arranged with the magnetic bead liquid container, gear teeth of the first gear disc are meshed with the gear on the magnetic bead liquid container, and the magnetic bead liquid container is driven to rotate.

In one embodiment, the kit further comprises a reagent assembly, wherein the reagent assembly comprises a test tube holder, at least one additional reagent tube for storing other reagents, and the magnetic bead liquid container, the magnetic bead liquid container is rotatably mounted on the test tube holder, and the test tube holder is detachably mounted on the mounting portion.

The application provides a sample analysis equipment, includes above-mentioned any mixing device for carry out the mixing to the magnetic bead reagent.

The beneficial effect of this application:

through the relative motion between magnetic bead reagent and magnetic field, change the direction that magnetic force acted on the magnetic bead for the magnetic bead flows along each different direction under the magnetic force effect, reaches the purpose of mixing, need not the manual mixing of user, has promoted the efficiency of mixing magnetic bead reagent greatly.

Drawings

FIG. 1 is a schematic diagram of a deposition state of a magnetic bead reagent (when a magnetic field has not attracted a magnetic bead) according to an embodiment of the present invention;

FIG. 2 is a schematic diagram of a magnetic field attracting magnetic beads in one embodiment of the present disclosure;

FIG. 3 is a top view of a blending apparatus according to an embodiment of the present disclosure;

FIG. 4 is a schematic structural diagram of a first driving assembly according to an embodiment of the present disclosure;

FIG. 5 is a schematic view of a mixer apparatus with an external cover according to one embodiment of the present disclosure.

Detailed Description

The present application will now be described in further detail by way of the detailed description and with reference to the accompanying drawings, in which like elements in different embodiments are referred to by like reference numerals. In the following description, numerous details are set forth in order to provide a better understanding of the present application. However, those skilled in the art will readily recognize that some of the features may be omitted or replaced with other elements, materials, methods in different instances. In some instances, certain operations related to the present application have not been shown or described in detail in order to avoid obscuring the core of the present application from excessive description, and it is not necessary for those skilled in the art to describe these operations in detail, so that they may be fully understood from the description in the specification and the general knowledge in the art.

Furthermore, the features, operations, or characteristics described in the specification may be combined in any suitable manner to form various embodiments. Also, the various steps or actions in the method descriptions may be transposed or transposed in order, as will be apparent to one of ordinary skill in the art. Thus, the various sequences in the specification and drawings are for the purpose of describing certain embodiments only and are not intended to imply a required sequence unless otherwise indicated where such sequence must be followed.

The numbering of the components as such, e.g., "first", "second", etc., is used herein only to distinguish the objects as described, and does not have any sequential or technical meaning. The term "connected" and "coupled" when used in this application, unless otherwise indicated, includes both direct and indirect connections (couplings).

The embodiment provides a mixing device of a magnetic bead reagent.

Referring to fig. 1 and 2, the mixing apparatus includes a magnetic member 100, a reagent container storing mechanism (not shown), and a driving mechanism (not shown).

The magnetic member 100 is used to generate a magnetic field. The magnetic member 100 may be a magnet, or may be an electromagnetic component, such as an energized coil, as long as the magnetic effect can be generated, and thus belongs to the magnetic member 100 shown in the present embodiment.

The reagent container storage mechanism has at least one mounting portion for mounting a magnetic bead solution container 410 for storing a magnetic bead reagent to be mixed uniformly, and the mounting portion is arranged corresponding to the magnetic member 100, so that the magnetic bead solution container 410 on the mounting portion can be located in a magnetic field. The relative position of the mounting portion and the magnetic member 100 is defined by the relative position of the magnetic bead solution container 410 and the magnetic field. In fact, the mounting portion can be located at any position relative to the magnetic member 100, and it is only necessary that the magnetic bead solution container 410 located on the mounting portion falls within the magnetic field of the corresponding magnetic member 100. For example, the mounting portion may be located above the magnetic member 100, flush with the magnetic member 100, below the magnetic member 100, etc. by the structural arrangement of the mounting portion and the magnetic bead solution container 410, the magnetic bead solution container 410 may finally fall into the magnetic field of the corresponding magnetic member 100.

The drive mechanism has a drive structure that can drive at least one of the magnetic material 100, the mounting unit, and the magnetic bead solution container 410 to move and can move the magnetic bead solution container 410 with respect to the magnetic field. That is, the driving mechanism is in transmission connection with at least one of the magnetic element 100, the mounting portion and the magnetic bead solution container 410, so as to drive the magnetic bead solution container 410 to move relative to the magnetic field. The movement of the magnetic bead fluid container 410 relative to the magnetic field includes, but is not limited to, rotation, translation, inversion, etc. along its axis.

The driving mechanism can use various power sources (such as a motor, a cylinder, a hydraulic cylinder, an electromagnet, etc.) as driving force, and transmits the motion to at least one of the magnetic element 100, the mounting portion, and the magnetic bead solution container 410 through corresponding transmission mechanisms. Referring to FIG. 1, before the magnetic bead reagent is mixed, a large number of magnetic beads 411 will be deposited on the bottom of the magnetic bead solution container 410. Then, as shown in fig. 2, through the relative motion between magnetic bead reagent and the magnetic field, change the direction that magnetic force acted on magnetic bead 411 for magnetic bead 411 flows along each different direction under the magnetic force effect, breaks away from magnetic bead 411 from the bottom in the short time, reaches the purpose of quick mixing, need not the manual mixing of user, has promoted the efficiency of mixing magnetic bead reagent greatly.

According to the above principle, when one of the magnetic element 100, the mounting portion and the magnetic bead liquid container 410 moves, the relative movement between the magnetic bead reagent and the magnetic field can be realized, and of course, any two movements or all three movements of the magnetic element 100, the mounting portion and the magnetic bead liquid container 410 may realize the relative movement between the magnetic bead reagent and the magnetic field.

It should be noted that, in order to better illustrate the inventive concept, the present embodiment is described with the magnetic bead fluid container 410 being introduced, and the magnetic bead fluid container 410 is shown in the attached drawings. However, in practice, the mixing apparatus of the present embodiment may or may not include the magnetic bead liquid container 410, that is, in one embodiment, the magnetic bead liquid container 410 may be regarded as a component of the mixing apparatus, and in another embodiment, the magnetic bead liquid container 410 may be regarded as a target of use of the mixing apparatus, rather than a component of the mixing apparatus. The magnetic bead fluid container 410 mentioned herein refers to only the magnetic bead 411 lumen itself, which may be present alone or may be combined with other tubes to form the reagent assembly 400, as shown in fig. 1 and 2, and the reagent assembly 400 includes not only the magnetic bead fluid container 410 but also other related reagent containers 440.

Further, in one embodiment, the mounting portion has a configuration that defines a longitudinally extending arrangement of bead fluid reservoirs 410 along a first axis. The magnetic bead solution container 410 is disposed to extend longitudinally along the first axis, which means that the central axis of the magnetic bead solution container 410 coincides with the first axis, that is, the central axis of the magnetic bead solution container 410 is considered to be the first axis of the corresponding mounting portion after the magnetic bead solution container is mounted to the mounting portion.

Referring to fig. 1 and 2, in one embodiment, the magnetic member 100 has a south pole or a north pole disposed at a non-zero angle with respect to the first axis. That is, the south pole or the north pole of the magnetic member 100 is disposed toward the chamber sidewall of the magnetic bead solution container 410. So that the south pole and the north pole of the magnetic member 100 are not oriented at an angle of zero degrees with respect to the central axis of the magnetic bead fluid container 410. When the magnetic member 100 is a magnet, the south pole or the north pole of the magnetic member 100 is disposed at a non-zero angle with respect to the first axis, which can be regarded as the magnetizing direction of the magnetic member is disposed at a non-zero angle with respect to the first axis.

The magnetic induction lines 110 of the magnetic element 100 can be concentrated on the side of the magnetic bead liquid container 410 more, so that the magnetic beads 411 deposited on the bottom of the magnetic bead liquid container 410 can be sucked away and dispersed more quickly, and the blending effect can be improved. Particularly, when the magnetic bead solution container 410 performs a rotation motion around its central axis, the magnetic beads 411 can move in a larger range under a magnetic field, thereby improving the uniform mixing effect. Furthermore, the magnetic bead solution container 410 may be installed in a space as large as possible between the upper and lower sides of the magnetic bead solution container 410 to provide more space for the installation unit.

In some more specific embodiments, the south or north pole of the magnetic element 100 may be at an angle of 15 °, 30 °, 45 °, 60 °, 75 °, 90 °, or any other angle other than 0 ° to the first axis.

Further, referring to fig. 1, in one embodiment, the south pole or the north pole of the magnetic member 100 faces the first axis perpendicularly. That is, the south pole or the north pole of the magnetic member 100 is vertically oriented toward the chamber sidewall of the magnetic bead solution container 410. The vertical arrangement can make most of the magnetic induction wires 110 of the magnetic element 100 pass through the side wall of the magnetic bead liquid container 410 and act on the magnetic beads 411, thereby further improving the uniform mixing effect of the magnetic beads 411.

Further, repeated experiments and analyses by the inventor find that, when the magnetic bead solution container 410 rotates around the central axis thereof, on one hand, the direction of the magnetic force acting on the magnetic beads 411 changes, and on the other hand, the centrifugal force generated by the rotation is also beneficial to the uniform mixing of the magnetic beads 411, and the two effects are combined to generate a better uniform mixing effect.

Thus, in one embodiment, the driving mechanism comprises a first driving assembly capable of driving the magnetic bead fluid container 410 to rotate in forward and reverse directions alternately. That is, the first driving assembly is in transmission connection with the magnetic bead solution container 410 to drive the magnetic bead solution container 410 to rotate in the forward direction and the reverse direction alternately. The rotation here means that the magnetic bead solution container 410 rotates around its central axis.

The first driving assembly may be in transmission connection with the magnetic bead liquid container 410 by using various transmission mechanisms, such as a gear transmission mechanism, a synchronous belt transmission mechanism, a chain transmission mechanism, and the like.

Through the rotation of first drive assembly drive magnetic bead liquid container 410 forward rotation in turn and reverse rotation, make magnetic force act on the direction of magnetic bead 411 to have changed on the one hand, the centrifugal force that on the other hand rotation produced also is favorable to the mixing of magnetic bead 411, better mixing effect can be produced in the combination of these two aspect effects, and rotation direction constantly changes and makes the direction of centrifugal force constantly change to mixing effect has further been promoted.

Of course, as a variation of this embodiment, the forward rotation and the reverse rotation of the magnetic bead fluid container 410 may be performed at the same or different time periods, or the forward rotation and the reverse rotation of the magnetic bead fluid container 410 may be performed at periodically varying time periods.

Further, referring to fig. 3, fig. 3 shows a reagent container storage mechanism 200 and a mounting portion 210 thereon. In one embodiment, the number of the mounting portions 210 is at least two, and the mounting portions are distributed along an arc or a circle on the periphery of the magnetic member 100, so that the magnetic bead solution containers 410 on the mounting portions 210 can be arranged around the magnetic member 100. This arrangement of mounting portions 210 can improve the compactness of the entire device, reduce the device volume, and increase the number of mounting portions 210 in the same area, so as to place more magnetic bead solution containers 410.

Further, referring to fig. 3 and 4, in an embodiment, the reagent container storing mechanism 200 includes a ring-shaped base 220, the mounting portion 210 is disposed on the ring-shaped base 220, and the magnetic member 100 is fixedly or movably disposed at a middle hole of the ring-shaped base 220.

The ring-shaped base 220 allows the magnetic bead solution container 410 to surround the magnetic member 100 in an arc or circle after being mounted on the mounting portion 210. The hole position in the middle of the annular base 220 gives up the placement position of the magnetic part 100, and the position of the annular base 220 and the position of the magnetic part 100 are prevented from colliding, so that the whole device is more compact in structure and smaller in size.

There are many driving structures capable of driving the magnetic bead solution container 410 to rotate, and from the viewpoint of miniaturization of the transmission structure and transmission accuracy, the inventors chose to adopt a gear transmission structure, and further made the following improvement in one embodiment.

Referring to fig. 1-4, in one embodiment, the first driving assembly 300 includes a first gear plate 310, a second gear plate 320 coaxially disposed and fixedly connected with the annular base 220, and a motor 330 for driving the second gear plate 320 to rotate. The first gear plate 310 is fixedly disposed and located at the central hole of the annular base 220. The mounting portion 210 is disposed around the first gear plate 310 in an arc or circle. The magnetic bead solution container 410 is provided with a gear 430 coaxially disposed therewith, as shown in FIGS. 1 and 2. As shown in fig. 3, the teeth of the first gear plate 310 extend into the magnetic bead solution container mounting region (where the magnetic bead solution container 410 is located) of the corresponding mounting portion 210, so that the teeth of the first gear plate 310 can be engaged with the gear 430 on the magnetic bead solution container 410.

Adopt motor 330 drive second toothed disc 320 to rotate, this second toothed disc 320 and annular base 220 are coaxial and fixed connection, consequently will drive this annular base 220 and rotate, and then drive the magnetic bead liquid container 410 on it and rotate around first toothed disc 310, realize the revolution of mount pad 210 and magnetic bead liquid container 410 relative first toothed disc 310. The first gear plate 310 is engaged with the gear 430 of the magnetic bead solution container 410, so that when the magnetic bead solution container 410 rotates relative to the first gear plate 310, the first gear plate 310 will react with the magnetic bead solution container 410 to rotate. Adopt the gear drive structure on the one hand to be favorable to the miniaturization of structure and the promotion of transmission precision, on the other hand the shape characteristics of gear be convenient for realize in arc or circular region simultaneously with the gear 430 of two at least magnetic bead liquid containers 410 mesh mutually, the rotation of two at least magnetic bead liquid containers 410 of drive.

In other embodiments, if not considered from the above inventive concept, a chain transmission structure, a belt transmission structure or other suitable transmission structures may be adopted as long as the magnetic bead solution container 410 can be driven to rotate.

Further, referring to fig. 3, in an embodiment, the magnetic member 100 is fixedly mounted on the first gear plate 310. This can greatly reduce the space occupied by the installation of the magnetic member 100. In the process that the magnetic bead liquid container 410 rotates around the magnetic part 100, the position of the magnetic bead liquid container 410 relative to the magnetic part 100 can be changed, so that the magnetic part 100 can magnetically attract magnetic beads 411 in the magnetic bead liquid container 410 from different directions, and the magnetic beads can move randomly in more directions, thereby enhancing the uniform mixing effect.

Specifically, when the mounting portion 210 rotates around the magnetic element 100, the magnetic bead solution container 410 can be driven to rotate around the magnetic element 100, which is equivalent to the magnetic bead solution container 410 revolving around the magnetic element 100. The technical scheme that the magnetic bead liquid container 410 revolves around the magnetic member 100 and the technical scheme that the magnetic bead liquid container 410 rotates can be separately used, and can achieve a uniform mixing effect. Such as the first gear plate 310, the second gear plate 320, and the motor 330.

Of course, although some embodiments may achieve more advantageous effects, the present invention should not be limited to the above-mentioned design concept, and the inventor believes that in other embodiments, the first driving assembly may also include the first gear plate 310 and a motor for driving the first gear plate 310 to rotate. The mounting portion 220 is disposed around the first gear plate 310 along an arc or a circle, and the gear teeth of the first gear plate 310 extend into the magnetic bead solution container mounting region corresponding to the mounting portion 220, so that the gear teeth of the first gear plate 310 can mesh with the gear 430 on the magnetic bead solution container 410 to drive the magnetic bead solution container 410 to rotate. In this embodiment, the ring-shaped base 220 (or the reagent container storage mechanism 200) may be held stationary while the first gear wheel 310 is rotated by a motor. When the first gear plate 310 rotates, the magnetic bead liquid container 410 also rotates relatively (the effect is equivalent to that the magnetic bead liquid container 410 revolves relatively to the first gear plate 310), and at the same time, the first gear plate 310 can still make the magnetic bead liquid container 410 rotate.

In the above embodiments, by changing the rotation direction of the output of the motor 330, the revolving direction (forward and reverse) of the magnetic bead solution container 410 with respect to the first gear plate 310 and the rotating direction (forward and reverse) thereof will be realized. Referring to fig. 1 and 2, the directions indicated by arrows a and b are the directions in which the magnetic bead solution container 410 can rotate.

In addition to the above embodiments, the magnetic bead solution container 410 may be rotated and then the magnetic bead solution container 410 may be revolved with respect to the magnetic material 100 in another manner. In one embodiment, the driving mechanism includes a second driving assembly (not shown) having an output end drivingly connected to the reagent container storage mechanism 200 for driving the mounting portion 210 to rotate about the magnetic member 100.

The second driving assembly drives the installation part 210 to rotate around the magnetic part 100, relative motion between the magnetic bead reagent and the magnetic field is realized through the motion of the installation part 210, and the magnetic bead reagent and the magnetic field are combined with a mixing effect generated by the rotation of the magnetic bead liquid container 410, so that the mixing effect of the mixing device can be further improved. Specifically, the second driving assembly may also employ the motor 330 or other suitable power source, and the second driving assembly may employ a gear transmission structure, a chain transmission structure, a belt transmission structure, or other suitable structure as the transmission structure. The first driving assembly 300 and the second driving assembly may also be driven by the same power source, for example, the same motor drives different transmission mechanisms to achieve the functions of the first driving assembly 300 and the second driving assembly.

Of course, the magnetic element 100 itself may be configured to rotate or be fixed in position while the magnetic bead solution container 410 revolves. When the magnetic member 100 is configured to rotate, the magnetic member 100 and the magnetic bead liquid container 410 may have different rotating speeds, so that the two motions are superimposed to generate different effects, thereby improving the mixing efficiency. And when the magnetic member 100 is configured to be fixed, for example, fixedly mounted on the first gear plate 310. The revolution of the magnetic bead liquid container 410 can make it switch between the magnetic fields of different magnetic members 100, thereby forming the movement in different directions and improving the mixing efficiency.

Further, the number of the magnetic members 100 can be selected according to actual requirements. Referring to fig. 1, in one embodiment, at least two magnetic members 100 are arranged on the first gear plate 310 along an arc or a circle.

The magnetic members 100 arranged in an arc or circle can be conveniently aligned with the magnetic bead fluid container 410 around the outer circumference thereof. In particular, when the magnetic material 100 is fixed in position while the magnetic bead solution container 410 is able to revolve, the magnetic material 100 can act on different magnetic bead solution containers 410 in sequence.

Further, as shown in fig. 3, in one embodiment, the magnetic members 100 are provided in the same number as the mounting portions 210, the mounting portions 210 are circularly surrounding the magnetic members 100, and each magnetic member 100 is disposed corresponding to one of the mounting portions 210, so that the magnetic bead solution container 410 on the mounting portion 210 can be located in the magnetic field of the corresponding magnetic member 100.

In the above structure, each magnetic bead solution container 410 can be located in a magnetic field corresponding to the magnetic bead solution container, and particularly, when the magnetic bead solution container 410 rotates relative to the corresponding magnetic member 100, the magnetic bead solution container 410 rotates, so that the magnetic beads 411 in the magnetic bead solution container 410 have a very good uniform mixing effect.

The position and structure of the mounting portion 210 determine whether or not the magnetic bead solution container 410 after mounting can be placed in the magnetic field and the mounting stability of the magnetic bead solution container 410 during the operation of the mixing apparatus. The inventor designs various embodiments with different positions and structures of the mounting portion 210 according to actual requirements, and certainly, the positions and structures of the mounting portion 210 are not limited to the embodiments shown below.

In one embodiment, the magnetic bead fluid container 410 can be a single unit. The magnetic bead solution container 410 is rotatably attached to the mounting portion 220.

In another embodiment, referring to fig. 3, a reagent assembly 400 as shown in fig. 1 and 2 is taken as an example, and the reagent assembly includes a reagent tube holder 420, at least one additional reagent tube 440 for storing other reagents, and a magnetic bead fluid container 410. The magnetic bead solution container 410 is rotatably mounted on the test tube holder 420, and the test tube holder 420 is detachably mounted on the mounting portion 210. For example, the mounting portion 210 may have a position-limiting protrusion and/or a position-limiting groove, and the magnetic bead solution container 410 may be mounted by fixing the test tube holder 420 through the position-limiting protrusion and/or the position-limiting groove.

In the present embodiment, the mounting portion 210 forms a mounting seat structure, and the mounting portion 210 can be disposed below the magnetic member 100, so that the mounted magnetic bead solution container 410 can be in the magnetic field of the magnetic member 100.

In another embodiment, the mounting portion has a clamping structure for clamping and releasing the bead fluid container. The magnetic bead liquid container is rotatably held by the holding structure.

When the magnetic bead liquid container is installed, the magnetic bead liquid container is clamped through the clamping structure, and the installation of the magnetic bead liquid container is achieved. In this embodiment, the clamping structure can centre gripping magnetic bead liquid container's upper portion, middle part or lower part, when the clamping structure is used for the upper portion of centre gripping magnetic bead liquid container, can set up the installation department in the side top of magnetic part, when the clamping structure is used for the middle part of centre gripping magnetic bead liquid container, can set up the installation department in the middle part position of magnetic part one side, when the clamping structure is used for the lower part of centre gripping magnetic bead liquid container, can set up the installation department in the side below of magnetic part, make the magnetic bead liquid container after the installation can be in the magnetic field of magnetic part.

In another embodiment, the mounting portion has a suspension structure for suspending the magnetic bead solution container.

When the magnetic bead liquid container is installed, the magnetic bead liquid container is hung on the suspension structure, so that the magnetic bead liquid container is installed. In this embodiment, the magnetic bead solution container is usually hung on the bottom of the mounting portion, so that the mounting portion can be disposed above the magnetic member, so that the mounted magnetic bead solution container can be located in the magnetic field of the magnetic member.

In other embodiments, the mounting portion may have other suitable mounting structures as long as the magnetic bead solution container can be mounted on the mounting portion.

Considering that external dust and suspended matters can be accumulated on the surface of the blending device, the service life and the working effect of the blending device are affected, and an operator can be injured if the operator carelessly extends hands into the first gear disc 310 during operation, the inventor adds an outer cover to the blending device in some embodiments.

Referring to FIG. 5, in one embodiment, the mixing apparatus further includes an outer cover 500, and the outer cover 500 is used to cover the top of the mixing apparatus.

The dustcoat 500 can reduce the dust of piling up on the mixing device surface on the one hand, prolongs the life of mixing device, promotes mixing device's working effect, and on the other hand also can reduce operator misoperation injured's possibility, has promoted mixing device's security.

After the blending device is provided with the outer cover 500, if the outer cover 500 is opened every time the magnetic bead liquid container 410 is taken and placed, the operation is inconvenient, and the inventors have provided the taking and placing port 510 on the outer cover 500 of some embodiments.

Referring to fig. 5, in an embodiment, the outer cover 500 has a pick-and-place opening 510, and the pick-and-place opening 510 is opened corresponding to the mounting portion 210 and the magnetic bead solution container 410.

The user can take and place the magnetic bead liquid container 410 through the taking and placing opening 510, so that the user does not need to frequently open and close the outer cover 500, and the operation of the user is convenient. In this embodiment, the access opening 510 is a sector, and in other embodiments, the access opening may also be disposed in a sector ring shape or other suitable shapes, so that when the access opening is a sector ring shape, the outer cover 500 can more effectively shield the first gear plate 310.

In another aspect, the present embodiment provides a sample analysis apparatus, including any one of the blending devices described above, for blending a magnetic bead reagent.

Specifically, the mixing device may be configured as a non-detachable part of the sample analysis apparatus, or may be configured as a detachable structure.

The foregoing is a more detailed description of the present application in connection with specific embodiments thereof, and it is not intended that the present application be limited to the specific embodiments thereof. It will be apparent to those skilled in the art from this disclosure that many more simple derivations or substitutions can be made without departing from the inventive concepts herein.

Claims

1. The utility model provides a mixing device of magnetic bead reagent which characterized in that includes:

a magnetic member for generating a magnetic field;

2. The mixing apparatus of claim 1, wherein the mounting portion is configured to define a longitudinal extension of the bead fluid container along a first axis, and wherein the magnetic member has a south pole or a north pole oriented at a non-zero angle with respect to the first axis.

3. The blending apparatus of claim 2, wherein the magnetic member has a south pole or a north pole oriented perpendicular to the first axis.

4. The mixing device of claim 1, wherein the drive mechanism comprises a first drive assembly capable of driving the magnetic bead fluid container to rotate in a forward direction and a reverse direction alternately.

5. The blending device according to claim 4, wherein the reagent container storage mechanism comprises at least two annular bases, the at least two annular bases are arranged along an arc or a circle, and the magnetic member is located at a middle hole of each annular base.

6. The blending device of claim 5, wherein the first driving assembly comprises a first gear disc, a second gear disc which is coaxially arranged on the annular base and is fixedly connected with the annular base, and a motor for driving the second gear disc to rotate, the first gear disc is fixedly arranged and is positioned at the middle hole position of the annular base, and the gear teeth of the first gear disc extend into the magnetic bead liquid container mounting area of the corresponding mounting part, so that the gear teeth of the first gear disc can be meshed with the gear on the magnetic bead liquid container to drive the magnetic bead liquid container to rotate.

7. The blending device of claim 5, wherein the first driving assembly comprises a first gear disc and a motor for driving the first gear disc to rotate, the first gear disc is arranged at the middle hole position of the annular base, and gear teeth of the first gear disc extend into the magnetic bead liquid container mounting area of the corresponding mounting part, so that the gear teeth of the first gear disc can be meshed with a gear on the magnetic bead liquid container.

8. The blending apparatus of claim 6 or 7, wherein the number of the magnetic members is at least two, and the magnetic members are fixedly arranged on the first gear plate along an arc or a circle.

9. The mixing device according to claim 8, wherein the number of the magnetic members is the same as that of the mounting portions, and each magnetic member is disposed corresponding to one of the mounting portions, so that the magnetic bead solution container on the mounting portion can be located in a magnetic field corresponding to the magnetic member.

10. The blending apparatus of claim 4, wherein the drive mechanism comprises a second drive assembly having an output end drivingly connected to the reagent container storage mechanism for driving the mounting portion to rotate about the magnetic element.

11. The utility model provides a mixing device of magnetic bead reagent which characterized in that includes:

a magnetic member for generating a magnetic field;

a reagent container storage mechanism having at least one mounting portion;

12. The mixing device of claim 11, wherein the magnetic member has a south pole or a north pole disposed toward the sidewall of the chamber of the magnetic bead fluid container.

13. The mixing apparatus of claim 12, wherein the south pole or the north pole of the magnetic member is oriented perpendicular to the sidewall of the chamber of the magnetic bead fluid container.

14. The blending device of claim 11, wherein the drive mechanism comprises a first drive assembly in driving connection with the bead solution container to drive the bead solution container to rotate in a forward direction and a reverse direction alternately.

15. The blending apparatus of claim 14, wherein the reagent container storage mechanism comprises at least two annular bases, the at least two mounting portions are arranged on the annular bases along an arc or a circle, and the magnetic member is located at a middle hole of the annular bases.

16. The blending device of claim 15, wherein the first driving assembly comprises a first gear disc, a second gear disc which is coaxially arranged with the annular base and is fixedly connected with the annular base, and a motor for driving the second gear disc to rotate, the first gear disc is fixedly arranged and is positioned at a middle hole position of the annular base, a gear which is coaxially arranged with the magnetic bead liquid container is installed on the magnetic bead liquid container, and gear teeth of the first gear disc are meshed with a gear on the magnetic bead liquid container to drive the magnetic bead liquid container to rotate.

17. The blending device of claim 15, wherein the first driving assembly comprises a first gear disc and a motor for driving the first gear disc to rotate, the mounting part is arranged around the first gear disc along an arc shape or a circular shape, the magnetic bead liquid container is provided with a gear coaxially arranged with the magnetic bead liquid container, and gear teeth of the first gear disc are meshed with the gear on the magnetic bead liquid container to drive the magnetic bead liquid container to rotate.

18. The blending apparatus of claim 16 or 17, wherein the number of the magnetic members is at least two, and the magnetic members are fixedly mounted on the first gear plate along an arc or a circle.

19. The mixing device of claim 18, wherein the number of the magnetic members is the same as that of the mounting portions, and each magnetic member is disposed corresponding to one of the mounting portions, so that the magnetic bead solution container on the mounting portion can be positioned in the magnetic field corresponding to the magnetic member.

20. The blending apparatus of claim 14, wherein the drive mechanism comprises a second drive assembly having an output end drivingly connected to the reagent container storage mechanism for driving the mounting portion about the magnetic element.

21. The mixing apparatus of claim 11, further comprising a reagent assembly, the reagent assembly comprising a test tube holder, at least one additional reagent tube for holding additional reagents, and the bead solution container, the bead solution container being rotatably mounted on the test tube holder, the test tube holder being detachably mounted on the mounting portion.

22. A sample analysis apparatus comprising the mixing apparatus of any one of claims 1-21 for mixing a magnetic bead reagent.