CN211536620U - Solid phase extraction device - Google Patents
Solid phase extraction device Download PDFInfo
- Publication number
- CN211536620U CN211536620U CN202020033381.4U CN202020033381U CN211536620U CN 211536620 U CN211536620 U CN 211536620U CN 202020033381 U CN202020033381 U CN 202020033381U CN 211536620 U CN211536620 U CN 211536620U
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- CN
- China
- Prior art keywords
- connecting hole
- phase extraction
- solid phase
- seal box
- waste liquid
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- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
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- 238000002414 normal-phase solid-phase extraction Methods 0.000 title claims abstract description 50
- 239000007788 liquid Substances 0.000 claims abstract description 73
- 230000000694 effects Effects 0.000 claims abstract description 6
- 239000002699 waste material Substances 0.000 claims description 37
- 238000007789 sealing Methods 0.000 claims description 14
- 230000000903 blocking effect Effects 0.000 claims description 5
- 238000005086 pumping Methods 0.000 claims 2
- 230000000149 penetrating effect Effects 0.000 claims 1
- 238000000605 extraction Methods 0.000 description 22
- 239000007791 liquid phase Substances 0.000 description 4
- 239000007787 solid Substances 0.000 description 4
- 239000000126 substance Substances 0.000 description 3
- 238000010586 diagram Methods 0.000 description 2
- 238000000034 method Methods 0.000 description 2
- 238000004587 chromatography analysis Methods 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 238000000746 purification Methods 0.000 description 1
- 238000011084 recovery Methods 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
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Abstract
The utility model discloses a solid phase extraction device, including the seal box, seal box upper end detachable is equipped with the apron, one side is equipped with place the platform in the seal box, place the platform top left side and right side are equipped with the recess to the indent respectively, the activity is equipped with the liquid receiving bottle respectively in the recess, link up directly over corresponding the liquid receiving bottle respectively on the apron and seted up first connecting hole and second connecting hole, swing joint is equipped with the solid phase extraction post respectively in first connecting hole and the second connecting hole, solid phase extraction post top side is connected respectively and is equipped with the siphunculus, the siphunculus other end is connected with the centrifugal pump respectively, the centrifugal pump is equipped with liquid feeding box through a suction pipe connection, still be equipped with the aspirating.
Description
Technical Field
The utility model relates to a medicine solid phase extraction field especially relates to a solid phase extraction device.
Background
The solid phase extraction operation is a very common and very important operation step in the chromatographic pretreatment process, and is related to the good and bad separation and purification effect of the substances to be detected and the interference substances, and whether the recovery and collection of the substances to be detected are successful or not, thereby playing a vital role in the correctness of the chromatographic analysis result.
Chinese patent application No.: 201820468093.4, discloses a disc type solid phase extraction device, which is a closed whole composed of an upper cover, a cylindrical shell and a base, wherein a disc is arranged in the cylindrical shell and below the upper cover, a plurality of collecting bottles are arranged on the outer circumference of the disc at equal intervals, an opening is arranged in the middle of the inner circle, a cylindrical sleeve is arranged between the disc and the base, a waste liquid collecting tank is arranged in the cylindrical sleeve, the top end of the waste liquid collecting tank is fixedly connected with the outer edge of the bottom of the opening, the lower end part of the waste liquid collecting tank is in an inverted cone structure, and the bottom of the waste; a plurality of small column shafts are respectively distributed on the inner circle of the upper cover, the position right above the opening and the outer circumference of the upper cover and right above the corresponding position of each collecting bottle, the small column shafts are of a through tubular structure and are communicated with the inside of the cylindrical shell and used for inserting a solid phase extraction column; the cylindrical shell is provided with an air exhaust hole, and the air exhaust hole is connected with a vacuum pump through an air exhaust pipe.
Chinese patent application No.: 201320832608.1 discloses a multi-column solid phase extraction device, which comprises a plurality of liquid phase solid small columns, a seal box, a vacuum extractor, a plurality of liquid receiving bottles, wherein one end of the liquid phase solid small column extends into the seal box, a plurality of liquid receiving bottles corresponding to the liquid phase solid small columns are detachably arranged in the seal box, the seal box is connected with the vacuum extractor, and the multi-column solid phase extraction device also comprises liquid receiving tanks corresponding to the liquid phase solid small columns with at least more than 2.
The invention has the following problems that 1, the existing invention has single function, liquid is poured into a solid phase extraction column mainly in a manual adding mode, then a closed cavity is vacuumized for extraction, and the liquid adding mode is complicated; 2. because the volume of the existing extraction column is limited, operators must continuously add liquid, and the extraction process is complex; 3. inconvenient discharges the extraction waste liquid among the current extraction device, and the discharge process is comparatively loaded down with trivial details.
Disclosure of Invention
Not enough to prior art exists, the utility model aims to provide a solid phase extraction device, its advantage lies in effectively having solved the loaded down with trivial details step that operating personnel need incessant interpolation liquid among the traditional extraction process, and the extraction process is more convenient to it is more convenient to discharge the extraction waste liquid, when needing to clap useless, directly take out first connecting hole respectively with the solid phase extraction post and put into in the second connecting hole, open the evacuation pump, make the extraction waste liquid directly flow into in the waste liquid bottle by the waste liquid pipe discharge.
In order to achieve the above purpose, the utility model provides a following technical scheme: the utility model provides a solid phase extraction device, including the seal box, seal box upper end detachable is equipped with the apron, one side is equipped with place the platform in the seal box, place the platform top left side and right side are equipped with the recess to the indent respectively, the activity is equipped with the liquid receiving bottle respectively in the recess, link up directly over corresponding the liquid receiving bottle respectively on the apron and seted up first connecting hole and second connecting hole, swing joint is equipped with the solid phase extraction post respectively in first connecting hole and the second connecting hole, solid phase extraction post top side is connected respectively and is equipped with the siphunculus, the siphunculus other end is connected with the centrifugal pump respectively, the centrifugal pump is equipped with liquid feeding box through a pipette connection, still.
Through adopting above-mentioned technical scheme, the extraction device adopts the liquid feeding case to utilize the centrifugal pump to carry out the liquid feeding to the solid-phase extraction column, has effectively avoided the loaded down with trivial details operation of operating personnel's incessant addition liquid, and the extraction process is more convenient.
The utility model discloses further set up to: and a waste liquid bottle is arranged on the other side in the sealing box, a waste liquid pipe is arranged on one side of the bottom of the waste liquid bottle, and the waste liquid pipe penetrates through the sealing box and is exposed outside the sealing box.
Through adopting above-mentioned technical scheme, the setting of waste liquid bottle makes when collecting and getting rid of the extraction waste liquid more convenient.
The utility model discloses further set up to: the cover plate is positioned right above the waste liquid bottle and is respectively provided with a third connecting hole and a fourth connecting hole in a through mode.
Through adopting above-mentioned technical scheme, solid-phase extraction post can be convenient for place to third connecting hole and fourth connecting hole, conveniently carry out the operation of wasting discharge.
The utility model discloses further set up to: the side parts of the tops of the first connecting hole, the second connecting hole, the third connecting hole and the fourth connecting hole are respectively and movably provided with a blocking cover matched with the first connecting hole to the fourth connecting hole.
Through adopting above-mentioned technical scheme, the setting of keeping off the lid makes can not place the connecting hole closure of solid phase extraction post when carrying out the evacuation extraction operation in the seal box for do not influence the solid phase extraction operation.
The utility model discloses further set up to: the outer side of the air exhaust hole is connected with a vacuum pump.
Through adopting above-mentioned technical scheme, can carry out the evacuation to the seal box to accomplish the solid-phase extraction operation.
The utility model discloses further set up to: the connecting end between apron and the seal box is equipped with first rubber seal.
By adopting the technical scheme: the sealing performance between the cover plate and the sealing box is better, and the solid-phase extraction operation effect is better.
The utility model discloses further set up to: and the upper ends and the lower ends of the inner walls of the first connecting hole, the second connecting hole, the third connecting hole and the fourth connecting hole are respectively provided with a second rubber sealing ring around the circumference.
Through adopting above-mentioned technical scheme for be connected more firmly between solid-phase extraction post and each connection accuse, the leakproofness can be good.
To sum up, the utility model has the advantages of it is following:
1. the traditional manual liquid adding mode is changed into a liquid adding box for adding liquid by using a centrifugal pump, the liquid adding mode is more convenient, the step of adding liquid without cutting off by operating personnel is avoided, and the labor force is effectively saved;
2. the extraction waste liquid can be effectively collected and discharged, and the waste liquid discharge operation is more convenient;
3. simple structure, small volume, convenient carrying and lower cost.
Drawings
FIG. 1 is a schematic diagram of the internal structure of a solid phase extraction apparatus of the present invention;
fig. 2 is a schematic structural diagram of the solid phase extraction device of the present invention.
Description of reference numerals: 1. a sealing box; 2. a cover plate; 3. placing a platform; 31. a liquid receiving bottle; 4. a first connection hole; 41. a second connection hole; 42. a solid phase extraction column; 43. pipe passing; 44. a centrifugal pump; 45. a pipette; 46. a liquid adding tank; 5. an air exhaust hole; 51. a waste liquid bottle; 52. a waste liquid pipe; 21. a blocking cover; 81. and a second seal ring.
Detailed Description
The present invention will be described in further detail with reference to the accompanying drawings.
As shown in FIGS. 1-2, the solid phase extraction apparatus of the present invention comprises a seal box 1, a cover plate 2 is detachably disposed on the upper end of the seal box 1, a placement platform 3 is disposed on one side of the interior of the seal box 1, a recess (not shown) is respectively disposed on the left side and the right side of the top of the placement platform 3 and is inwardly recessed, a liquid receiving bottle 31 is movably disposed in the recess, a first connection hole 4 and a second connection hole 41 are respectively formed on the cover plate 2 and are directly communicated with the liquid receiving bottle 31, a solid phase extraction column 42 is movably connected in the first connection hole 4 and the second connection hole 41, a through pipe 43 is respectively connected to the top side of the solid phase extraction column 42, the other end of the through pipe 43 is respectively connected to a centrifugal pump 44, the centrifugal pump 44 is connected to a liquid feeding box 46 through a liquid suction pipe 45, an air suction hole 5 is further disposed on the side wall of the seal box, the tedious operation that operating personnel must incessant addition liquid has effectively been avoided, and the extraction process is more convenient.
As shown in fig. 1-2, a waste liquid bottle 51 is further disposed at the other side of the sealed box 1, a waste liquid pipe 52 is disposed at one side of the bottom of the waste liquid bottle 51, the waste liquid pipe 52 penetrates through the sealed box 2 and is exposed outside the sealed box 2, and the waste liquid bottle 51 is disposed to facilitate collecting and removing extraction waste liquid.
As shown in fig. 1-2, the cover plate 2 is disposed directly above the waste liquid bottle 51 and has a third connection hole 61 and a fourth connection hole 62, and the third connection hole 61 and the fourth connection hole 62 are convenient for placing a solid-phase extraction column and facilitating waste discharge operation.
As shown in fig. 1-2, the blocking covers 21 respectively movably matched with the first to fourth connecting holes are disposed on the top sides of the first connecting hole 4, the second connecting hole 41, the third connecting hole 61 and the fourth connecting hole 62, and the blocking covers 21 are disposed to close the connecting holes where the solid phase extraction columns 42 are not disposed when the vacuum extraction operation is performed in the sealed box 2, so that the solid phase extraction operation is not affected.
As shown in fig. 2, a vacuum pump (not shown) is connected to the outside of the air extraction hole 6, and the vacuum pump can vacuumize the sealing box 1 to complete the solid phase extraction operation.
The connecting end is equipped with first rubber seal (not shown in the figure) between apron 2 and seal box 1, and first rubber seal makes between apron 2 and the seal box 1 sealing performance better, and solid-phase extraction operation effect is better.
As shown in fig. 1, the upper ends and the lower ends of the inner walls of the first connecting hole 4, the second connecting hole 41, the third connecting hole 61 and the fourth connecting hole 62 are respectively provided with a second rubber sealing ring 81 around one circle, and the arrangement of the second rubber sealing ring 81 makes the connection between the solid-phase extraction column and each connecting control more stable, and the sealing performance can be good.
In the above, the structure of the utility model is simple, by respectively arranging the through pipe 43 at the top end side of the solid phase extraction column 42, and respectively connecting the other end of the through pipe 43 with the centrifugal pump 44, and adding the liquid feeding box 46, and connecting the liquid feeding box 46 with the centrifugal pump 44 through the liquid feeding pipe 45, when performing solid phase extraction, the liquid in the liquid feeding box 46 is directly pumped into the liquid feeding pipe 45 through the liquid feeding box 46 by using the centrifugal pump 44, and finally is respectively sucked into the solid phase extraction column 42 through the through pipe 43, and then the vacuum pump is started to pump the seal box 1 for extraction, thereby effectively solving the tedious steps of uninterrupted liquid addition of operators in the traditional extraction process, the extraction process is more convenient, when the extraction is completed and waste needs to be tapped, the solid phase extraction column 42 is directly taken out of the first connecting hole 4 and the second connecting hole 41 and then is placed into the third connecting hole 61 and the fourth connecting hole 62, the vacuum pump is turned on again, and the waste liquid is discharged from the waste liquid tube 52 after directly flowing into the waste liquid bottle 51.
The above description is only the preferred embodiment of the present invention, and is not intended to limit the present invention, any modification, equivalent replacement, or improvement made within the design concept of the present invention should be included within the protection scope of the present invention.
Claims (7)
1. The utility model provides a solid phase extraction device, includes seal box (1), and seal box (1) upper end detachable is equipped with apron (2), its characterized in that: one side is equipped with place the platform (3) in seal box (1), place the left side of platform (3) top and right side are equipped with the recess to the indent respectively, the activity is equipped with respectively in the recess and connects liquid bottle (31), it has been seted up first connecting hole (4) and second connecting hole (41) to link up directly over corresponding liquid bottle (31) respectively on apron (2), swing joint is equipped with solid-phase extraction post (42) respectively in first connecting hole (4) and second connecting hole (41), solid-phase extraction post (42) top side is connected respectively and is equipped with siphunculus (43), siphunculus (43) other end is connected with centrifugal pump (44) respectively, centrifugal pump (44) are connected through a pipette (45) and are equipped with liquid feeding case (46), still be equipped with aspirating hole (6) on seal box (1) lateral wall.
2. A solid phase extraction apparatus according to claim 1, wherein: a waste liquid bottle () 51 is further arranged on the other side in the seal box (1), a waste liquid pipe (52) is arranged on one side of the bottom of the waste liquid bottle (51), and the waste liquid pipe (52) penetrates through the seal box (1) and is exposed outside the seal box (1).
3. A solid phase extraction apparatus according to claim 1, wherein: the cover plate (2) is positioned right above the waste liquid bottle (51) and is respectively provided with a third connecting hole (61) and a fourth connecting hole (62) in a penetrating way.
4. A solid phase extraction apparatus according to claim 1, wherein: and blocking covers (21) matched with the first connecting hole to the fourth connecting hole are movably arranged on the side of the tops of the first connecting hole (4), the second connecting hole (41), the third connecting hole (61) and the fourth connecting hole (62) respectively.
5. A solid phase extraction apparatus according to claim 1, wherein: and a vacuum pumping pump is connected and arranged at the outer side of the air pumping hole (6).
6. A solid phase extraction apparatus according to claim 1, wherein: and a first rubber sealing ring is arranged at the connecting end between the cover plate (2) and the seal box (1).
7. A solid phase extraction apparatus according to claim 1, wherein: and the upper ends and the lower ends of the inner walls of the first connecting hole (4), the second connecting hole (41), the third connecting hole (61) and the fourth connecting hole (62) are respectively provided with a second rubber sealing ring (81) around one circle.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202020033381.4U CN211536620U (en) | 2020-01-08 | 2020-01-08 | Solid phase extraction device |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202020033381.4U CN211536620U (en) | 2020-01-08 | 2020-01-08 | Solid phase extraction device |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN211536620U true CN211536620U (en) | 2020-09-22 |
Family
ID=72490476
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202020033381.4U Expired - Fee Related CN211536620U (en) | 2020-01-08 | 2020-01-08 | Solid phase extraction device |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN211536620U (en) |
-
2020
- 2020-01-08 CN CN202020033381.4U patent/CN211536620U/en not_active Expired - Fee Related
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| GR01 | Patent grant | ||
| GR01 | Patent grant | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20200922 |
|
| CF01 | Termination of patent right due to non-payment of annual fee |