CN211434411U - Adsorbent purification device for perfusion apparatus - Google Patents

Abstract

The utility model discloses an adsorbent purification device for perfusion apparatus, which comprises a purification tank, a heating tank and a condenser, wherein the bottom of the purification tank is provided with a filter, the liquid in the purification tank enters the heating tank through the filter and a siphon pipe, the top of the purification tank and the top of the heating tank are connected through a connecting pipe, and the condenser cools the connecting pipe; a screw type stirrer extending from the top is arranged in the purification tank. The adsorbent purifying device for the perfusion apparatus of the utility model increases the screw type stirrer with the length exceeding one half of the height of the tank body in the purifying tank, so that the adsorbent is more uniformly dispersed in the extraction reagent; the purification efficiency is improved.

Description

Adsorbent purification device for perfusion apparatus

Technical Field

The utility model relates to the field of medical equipment, in particular to an adsorbent purifying device for a perfusion apparatus.

Background

Progressive kidney disease can cause damage to the nephron and its progressive loss of function. Renal failure occurs when renal function is insufficient to maintain metabolic balance in the human body, and serious patients turn to uremia and are life-threatening. The annual incidence of the patients with the end-stage renal disease is 50-150 persons/million in the global scope, according to the survey of partial provinces and cities, the annual incidence of the patients with the end-stage renal disease in China is about 100 persons/million, and in order to cure the pictures of the endangered death risk, a dialysis method is proposed to remove diffusible substances from blood of the patients with the renal failure in the middle of 19 th century so as to contact the possibility of poisoning symptoms of the patients. Through the last hundred years of effort, the Dutch Kolff in 1943 firstly applied the regenerated cellulose dialyzer to clinic, and opened a new era of replacing kidney function with artificial device, actually, the basic technical concept of artificial kidney is to take the blood of patient out of body, through the devices (such as hemodialyzer, hemofilter, blood perfusion device, etc.) made by using different technical principles, complete the transfer and removal of solute and water in blood, and then return the purified blood to human body, achieving the purpose of treatment, namely, the transfer and removal of metabolic waste, poison, pathogenic factor, water and electrolyte to be removed in blood is completed through the biophysical mechanism of artificial kidney, thereby achieving the balance of internal environment. In recent years, basic research on artificial kidneys has been greatly advanced due to interpenetration of various disciplines, development of new devices has been advanced, and new technologies have emerged.

Among them, the application of the Hemoperfusion (HP) mode greatly expands the blood purification treatment means. The adsorbent filled in the perfusion apparatus adsorbs endogenous or exogenous toxins in blood, so that the toxin such as uremic toxin and excessive medicine in the body can be removed. In particular to middle and large molecular toxins which cannot be effectively removed by the conventional hemodialysis treatment, such as beta 2-microglobulin, and the like, which can be removed by a blood perfusion mode.

The adsorbing material has good biocompatibility, safety and no toxicity to human bodies, high mechanical strength and stable chemical properties. Currently used adsorbent materials include activated carbon and synthetic polymer-like materials. Most synthetic high molecular materials have cavities or active groups, are three-dimensional network structure high molecular polymers, have stable skeleton structures, and can keep inertia in acid and alkaline environments and partial organic solvent environments.

During the processing of the synthetic polymer material, some chemical substances, such as residual substances of monomers, solvents, catalysts, cross-linking agents and the like, are generally introduced, and effective removal is needed to ensure that the adsorbent is safe and harmless to toxic substances.

In order to remove fat-soluble residual substances in synthetic polymers, the conventional device is a Soxhlet extraction method, and the industrialized Soxhlet extraction method is to enlarge and process an adsorbent purification device for a perfusion apparatus commonly used in a laboratory. Because the amount of the extracted materials is large, the extraction time and the extraction rate of the materials at the lower layer and the upper layer of the extraction tank are inconsistent, and the batch difference of the materials is caused, so that the device capable of turning over the materials is used, and the full extraction and treatment of the materials are facilitated.

SUMMERY OF THE UTILITY MODEL

The utility model aims at providing an adsorbent purifying device for a perfusion apparatus, which has novel and unique structure and convenient use and can improve the purifying efficiency; the specific technical scheme is as follows:

an adsorbent purifying device for a perfusion apparatus comprises a purifying tank, a heating tank and a condenser, wherein a filter is arranged at the bottom of the purifying tank, liquid in the purifying tank enters the heating tank through the filter through a siphon pipe, the purifying tank is connected with the top of the heating tank through a connecting pipe, and the condenser cools the connecting pipe; a screw type stirrer extending from the top is arranged in the purification tank.

Further, the heating tank is heated by steam or by an electric heating device.

Further, the condenser takes cold water as a cold source.

Further, the purification device takes one of methanol, ethanol, ethyl acetate and methylal as a purification solvent.

Furthermore, the included angle between the blade angle of the screw type stirrer and the central shaft is 60-80 degrees.

Further, the blades of the screw agitator are polished.

The adsorbent purifying device for the perfusion apparatus of the utility model increases the screw type stirrer with the length exceeding one half of the height of the tank body in the purifying tank, so that the adsorbent is more uniformly dispersed in the extraction reagent; the purification efficiency is improved.

Drawings

FIG. 1 is a schematic structural view of an adsorbent purification device for a perfusion apparatus according to the present invention;

FIG. 2 is a schematic view of a heating tank configuration;

fig. 3 is a schematic view of the structure of the purification tank.

In the figure: 1. a frame; 2. a heating tank; 2-1, quickly opening hand holes; 2-2, connecting pipes; 2-3, sealing the end of the tank body; 2-4, a tank washer; 2-5, conical end sockets; 2-6, heating the side wall of the tank; 2-7, a coil pipe; 2-8, heat-insulating material; 2-9, an outer tank body; 2-10, heat preservation butterfly-shaped end sockets; 2-11, supporting legs; 3. a purification tank; 3-1, a motor; 3-2, a speed reducer; 3-3, hand hole; 3-4, sealing the tank body of the purification tank; 3-5, purifying tank top flange; 3-6, an observation window; 3-7, a screw stirrer; 3-8, purifying the side wall of the tank; 3-9, a discharge opening; 3-10, purifying tank bottom; 3-11, a filter; 3-12, a return pipe; 4. a siphon tube.

Detailed Description

The present invention will be more fully described with reference to the following examples. The present invention may be embodied in many different forms and should not be construed as limited to the exemplary embodiments set forth herein.

For ease of description, spatially relative terms, such as "upper," "lower," "left," "right," and the like, may be used herein to describe one element or feature's relationship to another element or feature as illustrated in the figures. It will be understood that the spatial terms are intended to encompass different orientations of the device in use or operation in addition to the orientation depicted in the figures. For example, if the device in the figures is turned over, elements described as "below" other elements or features would then be oriented "above" the other elements or features. Thus, the exemplary term "lower" can encompass both an upper and a lower orientation. The device may be otherwise oriented (rotated 90 degrees or at other orientations) and the spatially relative descriptors used herein interpreted accordingly.

As shown in fig. 1, the adsorbent purifying apparatus for a perfusion apparatus in this embodiment includes a purifying tank 3, a heating tank 2, and a condenser, wherein a filter a is disposed at the bottom of the purifying tank 3, liquid in the purifying tank 3 enters the heating tank 2 through the filter a and a siphon 4, the top of the purifying tank 3 and the top of the heating tank 2 are connected through a connecting pipe, and the condenser cools the connecting pipe; a screw type stirrer 3-7 extending from the top is arranged in the purification tank 3. The height of the siphon 4 is between 2/3 and 4/5 of the purge tank height; the adsorbent for perfusion apparatus is placed in a purification tank 3, and the heating tank 2 is filled with a low boiling point organic solvent as a purification solvent, such as methanol, ethanol, ethyl acetate, methylal, etc. The siphon enters the lower middle portion of the heating tank 2. The purification device is also provided with a frame 1.

As shown in FIG. 2, the heating tank 2 comprises a tank body end socket 2-3, a heating tank side wall 2-6 and a supporting leg 2-11. The tank body end enclosure 2-3 is provided with a quick-opening hand hole 2-1, a connecting pipe 2-2 and a tank washer 2-4. A coil 2-7 is arranged outside the side wall 2-6 of the heating tank; 2-8 parts of thermal insulation material is wrapped outside the coil pipe 2-7; the heat insulation material 2-8 is sealed by the outer tank body 2-9, the heat insulation butterfly-shaped end socket 2-10 at the bottom of the outer tank body and the conical end socket 2-5 at the top of the outer tank body.

As shown in figure 3, the purification tank 3 comprises a purification tank body end enclosure 3-4, a purification tank side wall 3-8 and a purification tank bottom 3-10. The motor 3-1 drives the screw type stirrer 3-7 arranged at the top to rotate after being decelerated by the reducer 3-2; a return pipe 3-12 is arranged at the lower end of the tank bottom 3-10 of the purification tank; a transparent observation window 3-6 is arranged on the side wall 3-8 of the purification tank; the lower end of the side wall 3-8 of the purification tank is provided with a discharge opening 3-9; the tank body end enclosure 3-4 of the purification tank is connected with the side wall 3-8 of the purification tank through a tank top flange 3-5 of the purification tank.

The heating tank 2 may be heated by steam; can also be heated by an electric heating device; such as coils 2-7, installed in insulation. The purified solvent is vaporized after being heated and flows into a connecting pipe at the top; the temperature is lower because the connecting pipe is cooled by the condenser; the high-temperature purification solvent steam is condensed into liquid after being cooled in the connecting pipe and flows into the purification tank from the top of the purification tank. The purification solvent is mixed with an adsorbent for perfusion apparatus (hereinafter referred to as adsorbent) to dissolve organic impurities in the adsorbent. The bottom of the purifying tank is provided with a filter which is arranged in front of the siphon to prevent the adsorbent from entering the siphon 4 and the purifying solvent can enter the siphon. Along with the rising of the liquid level in the purifying tank, the liquid level in the siphon pipe also rises, when the liquid level in the siphon pipe reaches the top, a siphon is established, and the purifying solvent with the dissolved organic impurities flows back to the heating tank from the bottom of the heating tank through the siphon. The purification solvent with the dissolved organic impurities is heated, the purification solvent is distilled, the organic impurities are retained in the heating tank, and the consumption of the purification solvent in the purification device is little.

The bottom of the purifying tank 3 is higher than the bottom of the heating tank; preferably at a height greater than 1/2 of the height of the heating tank from the bottom of the heating tank.

The condenser uses cold water as a cold source. The cold water can be tap water or ice water with the temperature of about 0 ℃. The temperature of the connecting pipe can be controlled by changing the flow of the cold source liquid through the opening degree of the valve; a temperature sensor and a temperature controller can be arranged, and the temperature of the connecting pipe is controlled by automatically controlling the opening degree of the valve through the temperature controller.

The condenser should set up the one end that is close to the purifying tank at the connecting pipe, avoids purifying solvent too early condensation, drips back to the heating jar, influences purifying solvent's circulation efficiency.

The adsorbent has higher density and smaller particles than the purifying solvent, and can be settled around the filter, so that the filtering efficiency of the filter is reduced; as shown in fig. 3, the purification device in the embodiment is further provided with a screw type stirrer, and the screw type stirrer rotates to turn the adsorbing material at the bottom of the device to the upper part, falls down by means of gravity, and turns over circularly; avoid the adsorbent to pile up around the filter, influence filtration efficiency. The difference of the material extraction efficiency of the upper layer and the lower layer can be avoided.

The included angle between the blade angle of the screw type stirrer 3-7 and the central shaft is 60-80 degrees, and under the condition that stirring is started when the thickness of the adsorbent accumulated around the filter exceeds 1 meter, overlarge extrusion force cannot be generated on the adsorbent, so that the breakage rate of the materials is effectively reduced; the stirrer can be started intermittently, and the operation cost is saved.

The purifying tank is also provided with an observation window, and the top of the observation window is lower than the top of the side wall of the tank; the bottom is higher than 1/4 of the side wall. The liquid level in the purification tank is observed through the observation window, and the position of the liquid level reaching the side walls 1/4, 1/3, 1/2 of the tank can be selected to start the stirring paddles.

The rotating speed of the screw type stirrer is controlled to be 5-20 revolutions per minute; can be directly driven by a servo motor; the motor can also be used for driving through a speed reducer; and the frequency converter controls the rotating speed of the motor.

The blades can rotate in the forward direction and the reverse direction, and can be used for discharging materials out of the extractor.

The bottom of the purifying tank is provided with a pipeline leading to the heating tank, a stop valve is arranged in the pipeline, and the diameter of the pipeline is larger than that of the siphon pipe and is connected with the siphon pipe in parallel. During purification, the stop valve is closed, and the purification solvent is connected with the heating tank through the siphon pipe; after the adsorption material purifies, open the stop valve, remaining purification solvent accessible back flow A in the device is arranged fast and is carried out recovery processing in the storage liquid jar, has improved purification solvent's utilization ratio.

After the purified solvent is discharged, the purified adsorbent is discharged from a discharge opening A at the bottom; the screw type stirrer rotates reversely to assist the discharge of the adsorbent. The tank bottom flange is detached, and the filter can be taken out from the bottom and replaced.

To maintain the gas pressure equilibrium, a vent line is connected between the top of the heating tank and the top of the purge tank.

The above examples are only for illustrating the present invention, and besides, there are many different embodiments, which can be conceived by those skilled in the art after understanding the idea of the present invention, and therefore, they are not listed here.

Claims (6)

1. An adsorbent purifying device for a perfusion apparatus comprises a purifying tank, a heating tank and a condenser, wherein a filter is arranged at the bottom of the purifying tank, liquid in the purifying tank enters the bottom of the heating tank through the filter through a siphon pipe, the purifying tank is connected with the top of the heating tank through a connecting pipe, and the condenser cools the connecting pipe; it is characterized in that a screw type stirrer extending from the top is arranged in the purification tank.

2. The adsorbent purification apparatus for an infuser of claim 1, wherein the heating tank is heated by steam or by an electric heating device.

3. The adsorbent purification apparatus for perfusion apparatus according to claim 1, wherein the condenser uses cold water as a cold source.

4. The adsorbent purification apparatus for an infusion set according to claim 1, wherein the purification apparatus uses one of methanol, ethanol, ethyl acetate, and methylal as a purification solvent.

5. The adsorbent purification apparatus for perfusion apparatus according to claim 1, wherein the screw type stirrer has a blade angle of 60-80 ° from the central axis.

6. The sorbent cleaning apparatus for a cartridge of claim 5, wherein the screw agitator blades are polished.

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