CN211411084U - Chromatographic separation and purification equipment - Google Patents
Chromatographic separation and purification equipment Download PDFInfo
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- CN211411084U CN211411084U CN201922174533.2U CN201922174533U CN211411084U CN 211411084 U CN211411084 U CN 211411084U CN 201922174533 U CN201922174533 U CN 201922174533U CN 211411084 U CN211411084 U CN 211411084U
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Abstract
The utility model relates to a chromatographic separation and purification device, which comprises a chromatographic column, a total feeding pipe and a total discharging pipe, wherein the total feeding pipe and the total discharging pipe are communicated with the two ends of the chromatographic column, the chromatographic column comprises a long-strip-shaped cylinder body and resin filled in the cylinder body, a bearing net disc which cuts the inner space along the section of the cylinder body is fixed in the cylinder body, uniform quartz sand is paved on the bearing net disc, the space above the quartz sand is filled with the resin, the space in the cylinder body and below the bearing net disc is a liquid level observation area, and a transparent observation sight glass is arranged on the cylinder body of the liquid level observation area; the utility model discloses be provided with the liquid level observation area in the barrel lower part, observe this inside material liquid level through the observation sight glass on the barrel, prevent that the material delivery pump from managing to find time the material, the steady decline of the material of being convenient for is equipped with back flow and material delivery pump on total discharging pipe, can prevent that material delivery pump power from too big taking out the barrel interior material too fast, opens the material delivery pump simultaneously, has alleviateed the pressure that the barrel bottom material was taken out, remains stable.
Description
Technical Field
The utility model relates to a technical field of purification equipment, in particular to chromatographic separation purification equipment.
Background
Column chromatography is a chromatography technique performed in a glass tube or a metal tube, in which an adsorbent is filled in the tube to be in a column shape, such a tubular column is called an adsorption cylinder, and a method of separating a mixture using the adsorption cylinder, called adsorption column chromatography, can be used to separate most organic compounds, particularly complex natural products, and has a separation capacity ranging from several milligrams to several hundred milligrams, and thus is suitable for separating and refining a relatively large amount of organic compound samples, in which the adsorbent is a stationary phase and the eluent is a mobile phase, and the basic principle of the adsorbent is based on the difference in adsorption strength between each component of the eluent and the adsorbent, and is accomplished by repeating the processes of adsorption, desorption, re-adsorption, and re-desorption in the cylinder, but the level of a material in the cylinder cannot be observed in the conventional column chromatography technique, just can not be according to the liquid level condition material flow rate control at the within range that is fit for, the velocity of flow can not reach the purpose of effective separation purification material at the excessive speed, and the velocity of flow can prolong material purification separation time too slowly, reduces work efficiency to barrel bottom discharge mouth material resistance is big among the prior art, can not steadily flow out, and it is inhomogeneous to cause the velocity of flow, influences the separation effect, consequently, the present urgent need carry out necessary improvement to current barrel.
SUMMERY OF THE UTILITY MODEL
In order to solve the problems, the utility model provides a chromatographic separation and purification device.
The specific contents are as follows: the utility model provides a chromatographic fractionation purification equipment, this equipment includes chromatographic column, and with chromatographic column both ends intercommunication total inlet pipe and total discharging pipe, characterized by:
the chromatographic column comprises a long-strip-shaped cylinder body and resin filled in the cylinder body, wherein a bearing net disc for cutting off the inner space along the cross section of the cylinder body is fixed in the cylinder body, the shape of the bearing net disc is matched with that of the cross section of the cylinder body, uniform holes are formed in the bearing net disc, uniform quartz sand is paved on the bearing net disc, the resin is filled in the space above the quartz sand, a liquid level observation area is formed in the space below the bearing net disc in the cylinder body, and a transparent observation sight glass is arranged on the cylinder body of the liquid level observation area;
one end of the main feeding pipe is communicated with the top of the cylinder body, the other end of the main feeding pipe is communicated with the valve A, one end of the main discharging pipe is communicated with the bottom of the cylinder body, the other end of the main discharging pipe is also communicated with the valve A, and the cylinder body, the main feeding pipe, the valve A and the main discharging pipe are connected in series to form a closed passage;
the device comprises a main feeding pipe, a flow meter M1 and an electric control valve, wherein the main feeding pipe is connected with the middle unit pipe, the feeding pipe, the air pressure pipe and the deionized water pipe in parallel, the middle unit pipe, the feeding pipe, the air pressure pipe and the deionized water pipe are connected to the main feeding pipe in series, the flow meter M1 and the electric control valve are connected to the main feeding pipe in series, the middle unit pipe, the feeding pipe, the air pressure pipe and the deionized water pipe are connected to the main feeding pipe between the flow meter M1 and the valve A in parallel, and the electric control valve is located on the main feeding pipe between the flow meter M1 and a cylinder body;
the main discharging pipe is communicated with a qualified material pipe, a waste liquid pipe and an unqualified material pipe, the qualified material pipe, the waste liquid pipe and the unqualified material pipe are communicated with the main discharging pipe in parallel, the qualified material pipe, the waste liquid pipe and the unqualified material pipe are respectively connected with a valve G, a valve H and a valve I in series, the main discharging pipe is connected with a valve J, a material conveying pump and a flowmeter M2 in series, the qualified material pipe, the waste liquid pipe and the unqualified material pipe are positioned on the main discharging pipe between the flowmeter M2 and the valve A, the material conveying pump is positioned on the main discharging pipe between the flowmeter M2 and the valve J, the valve J is positioned on the main discharging pipe between the material conveying pump and the barrel, a return pipe is also connected in parallel on the main discharging pipe, one end of the return pipe is communicated with the main discharging pipe between the flowmeter M2 and the material conveying pump, and the other, the return pipe is connected in series with a valve K.
Preferably, the upper end of the cylinder body is communicated with an overflow pipe, the free end of the overflow pipe is communicated with the collecting tank, and a valve L is connected on the overflow pipe in series.
Preferably, the upper end of the cylinder is communicated with an exhaust pipe, a valve M is connected in series on the exhaust pipe, and a pressure gauge is communicated on the exhaust pipe between the valve M and the cylinder.
Preferably, the lower end of the cylinder body is provided with a discharge opening.
Preferably, the lower port of the qualified material pipe is communicated with the qualified material barrel.
Preferably, the lower end of the waste liquid pipe is communicated with the waste liquid barrel.
Preferably, the lower end of the unqualified material pipe is communicated with the unqualified material barrel.
Preferably, the cylinder is a stainless steel pipe, and the bearing net disc is made of stainless steel.
The utility model has the advantages of:
the utility model relates to a chromatographic separation and purification device, which comprises a chromatographic column, a total inlet pipe and a total outlet pipe communicated with two ends of the chromatographic column, wherein the chromatographic column comprises a long-strip-shaped barrel body and resin filled in the barrel body, a bearing net disc which cuts an inner space along the cross section of the barrel body is fixed in the barrel body, uniform quartz sand is paved on the bearing net disc, the space above the quartz sand is filled with the resin, a liquid level observation area is arranged at the lower part of the net disc in the barrel body, a transparent observation sight glass is arranged on the barrel body of the liquid level observation area, the material liquid level in the space is observed through the sight glass, the material pumped by a material conveying pump is prevented from being pumped out, the material is convenient to stably descend, a better separation effect is achieved, a return pipe and the material conveying pump are arranged on the total outlet pipe, the material conveying pump can be prevented from being pumped out too fast due to the overlarge power of the material, the pressure for pumping out the materials at the bottom of the cylinder body is reduced, the material liquid pressure in the cylinder body is kept consistent, the flow velocity is kept in a proper range, and the separation effect is improved.
Drawings
FIG. 1 is a schematic view showing the connection relationship of a chromatographic separation and purification apparatus;
FIG. 2 is a first cross-sectional view of a chromatography column;
FIG. 3 is a second cross-sectional view of a chromatography column;
in the figure: 38. the chromatographic column comprises a cylinder body of a chromatographic column, 11 parts of a total feeding pipe, 29 parts of a total discharging pipe, 46 parts of quartz sand, 47 parts of resin, 44 parts of a bearing screen disc, 45 parts of an aperture, 48 parts of a liquid level observation area, 35 parts of an observation view mirror, 22 parts of a valve A and 14 parts of a single pipe, 16 parts of a feeding pipe, 18 parts of an air pressure pipe, 20 parts of a deionized water pipe, 15 parts of a valve B and 17 parts of a valve C and 19 parts of a valve D and 21 parts of a valve E and 13 parts of a flow meter M1 and 12 parts of an electric control valve, 49 parts of a qualified material pipe, 50 parts of a waste liquid pipe, 51 parts of a unqualified material pipe, 27 parts of a valve G and 26 parts of a valve H and 23 parts of a valve I and 32 parts of a valve J and 31 parts of a material delivery pump, 30 parts of a flow meter M2 and 33 parts of a return pipe, 34 parts of a valve K and 42 parts of an overflow pipe, 37 parts of a collection tank, 41 parts of, 24. And (7) unqualified buckets.
Detailed Description
Embodiment one, refer to fig. 1-3, a chromatographic separation and purification apparatus, the apparatus comprises a chromatographic column, and a total feed pipe and a total discharge pipe communicated with two ends of the chromatographic column;
the chromatographic column comprises a long-strip-shaped cylinder body and resin filled in the cylinder body, wherein a bearing net disc for cutting off the inner space along the cross section of the cylinder body is fixed in the cylinder body, the shape of the bearing net disc is matched with that of the cross section of the cylinder body, uniform holes are formed in the bearing net disc, uniform quartz sand is paved on the bearing net disc, the resin is filled in the space above the quartz sand, a liquid level observation area is formed in the space below the bearing net disc in the cylinder body, and a transparent observation sight glass is arranged on the cylinder body of the liquid level observation area; the barrel be stainless steel pipe, the bearing net dish is stainless steel material, the effect of bearing net dish is to hold the quartz sand layer, prevent that the resin from flowing from below.
One end of the main feeding pipe is communicated with the top of the cylinder body, the other end of the main feeding pipe is communicated with the valve A, one end of the main discharging pipe is communicated with the bottom of the cylinder body, the other end of the main discharging pipe is also communicated with the valve A, and the cylinder body, the main feeding pipe, the valve A and the main discharging pipe are connected in series to form a closed passage;
the device comprises a main feeding pipe, a flow meter M1 and an electric control valve, wherein the main feeding pipe is connected with the middle unit pipe, the feeding pipe, the air pressure pipe and the deionized water pipe in parallel, the middle unit pipe, the feeding pipe, the air pressure pipe and the deionized water pipe are connected to the main feeding pipe in series, the flow meter M1 and the electric control valve are connected to the main feeding pipe in series, the middle unit pipe, the feeding pipe, the air pressure pipe and the deionized water pipe are connected to the main feeding pipe between the flow meter M1 and the valve A in parallel, and the electric control valve is located on the main feeding pipe between the flow meter M1 and a cylinder body; under the action of the middle unit pipe, when qualified materials are collected, the materials are collected in the early stage due to the fact that the content of the purified materials is low, and the middle unit is poured from the middle unit pipe after the next batch of materials is fed and the liquid level is well controlled;
the main discharging pipe is communicated with a qualified material pipe, a waste liquid pipe and an unqualified material pipe, the qualified material pipe, the waste liquid pipe and the unqualified material pipe are communicated with the main discharging pipe in parallel, the qualified material pipe, the waste liquid pipe and the unqualified material pipe are respectively connected with a valve G, a valve H and a valve I in series, the main discharging pipe is connected with a valve J, a material conveying pump and a flowmeter M2 in series, the qualified material pipe, the waste liquid pipe and the unqualified material pipe are positioned on the main discharging pipe between the flowmeter M2 and the valve A, the material conveying pump is positioned on the main discharging pipe between the flowmeter M2 and the valve J, the valve J is positioned on the main discharging pipe between the material conveying pump and the barrel, a return pipe is also connected in parallel on the main discharging pipe, one end of the return pipe is communicated with the main discharging pipe between the flowmeter M2 and the material conveying pump, and the other, the return pipe is connected in series with a valve K.
The upper end of the cylinder body is communicated with an overflow pipe, the free end of the overflow pipe is communicated with a collecting tank, and a valve L is connected on the overflow pipe in series.
The upper end of the cylinder is communicated with an exhaust pipe, a valve M is connected in series on the exhaust pipe, and a pressure gauge is connected on the exhaust pipe between the valve M and the cylinder.
The lower end of the barrel is provided with a discharge opening, the lower end opening of the qualified material pipe is communicated with the qualified charging basket, the lower end of the waste liquid pipe is communicated with the waste liquid charging basket, and the lower end of the unqualified material pipe is communicated with the unqualified charging basket.
The utility model discloses a process and principle:
feeding: the valve C and the electric control valve are opened, feeding is carried out in the barrel through the feeding pipe, the valve J, the material conveying pump and the valve H on the main discharging pipe are opened simultaneously, waste liquid in the barrel flows out, resistance of outflow of the material is reduced under the action of the material conveying pump, after the material enters the barrel, the valve C on the feeding pipe is closed, the valve E on the deionized water pipe is opened, the operation of a flowing system in the barrel is maintained, the valve G on the qualified material pipe is opened for sampling detection, when the target extract is detected, the valve H is closed, the valve I is opened, the unqualified section material liquid is collected, when the concentration of the target extract is detected to reach a collection standard, the valve I is closed, the valve G is opened, and the high-concentration qualified material is. When the concentration of the target extract is detected to be lower than the standard value by sampling, closing the valve G, opening the valve I to discharge unqualified materials, and when the base line is detected to be basically stable by sampling, closing the deionized water valve E and the valve I, and opening the valve A to circulate the flow system in the cylinder.
Monitoring the flow rate of the chromatographic column: in the feeding process, the liquid level condition of the bottom space of the chromatographic column is observed through the observation lens, the opening degree of the electric control valve is adjusted according to the data of the flow meters M1 and M2, the liquid level reaches the set standard height, the aim of controlling the flow rate in the cylinder is achieved, the return pipe and the valve K are additionally arranged between the valve J and the flow meter M2, and the situation that the materials in the cylinder are excessively pumped out due to the fact that the power of the material conveying pump is too large can be prevented.
Cleaning a chromatographic column and filling resin: after the chromatographic column operates for a certain time, backwashing is needed to be carried out on the resin in the cylinder, at the moment, a valve E, a valve A and a valve K on the deionized water pipe are opened, other valves are kept closed, the resin is back-flushed and cleaned by deionized water, and waste liquid and the resin are stored in a collection tank for recycling; when the resin needs to be replaced, the air pressure valve D, the electric control valve, the valve K and the valve H are opened to exhaust liquid in the cylinder, after all the valves are closed, the discharge opening in the cylinder and the flange cover at the top of the cylinder are opened, the waste resin is discharged, the discharge opening is closed, and new resin is poured into the cylinder from the top of the cylinder.
Claims (8)
1. The utility model provides a chromatographic fractionation purification equipment, this equipment includes chromatographic column, and with chromatographic column both ends intercommunication total inlet pipe and total discharging pipe, characterized by:
the chromatographic column comprises a long-strip-shaped cylinder body and resin filled in the cylinder body, wherein a bearing net disc for cutting off the inner space along the cross section of the cylinder body is fixed in the cylinder body, the shape of the bearing net disc is matched with that of the cross section of the cylinder body, uniform holes are formed in the bearing net disc, uniform quartz sand is paved on the bearing net disc, the resin is filled in the space above the quartz sand, a liquid level observation area is formed in the space below the bearing net disc in the cylinder body, and a transparent observation sight glass is arranged on the cylinder body of the liquid level observation area;
one end of the main feeding pipe is communicated with the top of the cylinder body, the other end of the main feeding pipe is communicated with the valve A, one end of the main discharging pipe is communicated with the bottom of the cylinder body, the other end of the main discharging pipe is also communicated with the valve A, and the cylinder body, the main feeding pipe, the valve A and the main discharging pipe are connected in series to form a closed passage;
the device comprises a main feeding pipe, a flow meter M1 and an electric control valve, wherein the main feeding pipe is connected with the middle unit pipe, the feeding pipe, the air pressure pipe and the deionized water pipe in parallel, the middle unit pipe, the feeding pipe, the air pressure pipe and the deionized water pipe are connected to the main feeding pipe in series, the flow meter M1 and the electric control valve are connected to the main feeding pipe in series, the middle unit pipe, the feeding pipe, the air pressure pipe and the deionized water pipe are connected to the main feeding pipe between the flow meter M1 and the valve A in parallel, and the electric control valve is located on the main feeding pipe between the flow meter M1 and a cylinder body;
the main discharging pipe is communicated with a qualified material pipe, a waste liquid pipe and an unqualified material pipe, the qualified material pipe, the waste liquid pipe and the unqualified material pipe are communicated with the main discharging pipe in parallel, the qualified material pipe, the waste liquid pipe and the unqualified material pipe are respectively connected with a valve G, a valve H and a valve I in series, the main discharging pipe is connected with a valve J, a material conveying pump and a flowmeter M2 in series, the qualified material pipe, the waste liquid pipe and the unqualified material pipe are positioned on the main discharging pipe between the flowmeter M2 and the valve A, the material conveying pump is positioned on the main discharging pipe between the flowmeter M2 and the valve J, the valve J is positioned on the main discharging pipe between the material conveying pump and the barrel, a return pipe is also connected in parallel on the main discharging pipe, one end of the return pipe is communicated with the main discharging pipe between the flowmeter M2 and the material conveying pump, and the other, the return pipe is connected in series with a valve K.
2. The chromatographic separation and purification device as claimed in claim 1, wherein: the upper end of the cylinder body is communicated with an overflow pipe, the free end of the overflow pipe is communicated with a collecting tank, and a valve L is connected on the overflow pipe in series.
3. The chromatographic separation and purification device as claimed in claim 1, wherein: the upper end of the cylinder is communicated with an exhaust pipe, a valve M is connected in series on the exhaust pipe, and a pressure gauge is connected on the exhaust pipe between the valve M and the cylinder.
4. The chromatographic separation and purification device as claimed in claim 1, wherein: the lower end of the cylinder body is provided with a discharge opening.
5. The chromatographic separation and purification device as claimed in claim 1, wherein: and the lower port of the qualified material pipe is communicated with the qualified material barrel.
6. The chromatographic separation and purification device as claimed in claim 1, wherein: the lower end of the waste liquid pipe is communicated with the waste liquid barrel.
7. The chromatographic separation and purification device as claimed in claim 1, wherein: the lower end of the unqualified material pipe is communicated with the unqualified material barrel.
8. The chromatographic separation and purification device as claimed in claim 1, wherein: the cylinder body is a stainless steel pipe, and the bearing net disc is made of stainless steel.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201922174533.2U CN211411084U (en) | 2019-12-07 | 2019-12-07 | Chromatographic separation and purification equipment |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201922174533.2U CN211411084U (en) | 2019-12-07 | 2019-12-07 | Chromatographic separation and purification equipment |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN211411084U true CN211411084U (en) | 2020-09-04 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201922174533.2U Active CN211411084U (en) | 2019-12-07 | 2019-12-07 | Chromatographic separation and purification equipment |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN211411084U (en) |
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2019
- 2019-12-07 CN CN201922174533.2U patent/CN211411084U/en active Active
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| Date | Code | Title | Description |
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| GR01 | Patent grant | ||
| GR01 | Patent grant | ||
| CP03 | Change of name, title or address |
Address after: 458000 No.9 Muping Road, Shancheng District, Hebi City, Henan Province Patentee after: Xintuoyang Bioengineering Co.,Ltd. Address before: No.306, 3rd floor, business incubator building, hebide foreign exchange business park, Shancheng District, Hebi City, Henan Province Patentee before: Xintuoyang Bioengineering Co.,Ltd. |
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| CP03 | Change of name, title or address |