CN211381318U

CN211381318U - Vascular endothelial function detection equipment based on elastic wire technology

Info

Publication number: CN211381318U
Application number: CN201921721011.3U
Authority: CN
Inventors: 徐晨昱; 张捷; 王庆厚; 杨柳海
Original assignee: Shanghai Zhongjia Hengtai Medical Science & Technology Co ltd
Current assignee: Shanghai Zhongjia Hengtai Medical Science & Technology Co ltd
Priority date: 2019-10-15
Filing date: 2019-10-15
Publication date: 2020-09-01
Anticipated expiration: 2029-10-15

Abstract

The utility model belongs to the technical field of medical product, concretely relates to vascular endothelial function check out test set based on elastic wire technique, including two wireless dactylotheca and a control terminal. The wireless finger stall is internally provided with a sign sensor made of an elastic lead, converts fingertip pulse signals into elastic lead length changes, converts the elastic lead length changes into electric signals and transmits the electric signals to the control terminal in a wireless transmission mode. And the control terminal displays the real-time pulse wave signals, processes the signals and obtains a diagnosis conclusion. The utility model provides a portable vascular endothelial function check out test set, this check out test set easy operation, the test is accurate, the low price, the early examination of the vascular endothelial function of specially adapted crowd and daily monitoring.

Description

Vascular endothelial function detection equipment based on elastic wire technology

Technical Field

The utility model belongs to the technical field of medical product, concretely relates to vascular endothelial function check out test set based on elastic wire technique.

Background

Vascular endothelial cells are a smooth and continuous monolayer of cells that covers the lumen of a blood vessel and play a vital role in regulating vascular function and maintaining vascular structure. Once endothelial cell function is impaired, blood vessels are more prone to constriction and can lead to atherosclerotic changes such as proliferation of vascular smooth muscle, expression of inflammatory factors, oxidation of lipoproteins, platelet aggregation, and thrombus formation, ultimately leading to various cardiovascular events. Early endothelial dysfunction is reversible, and by using an effective diagnosis method, the endothelial dysfunction is discovered early and the intervention is treated in time, so that the damage of the endothelial function can be reversed, and the incidence and the death rate of cardiovascular diseases are reduced.

In the prior art, coronary angiography is the gold standard for determining vascular endothelial function, and acetylcholine is injected into coronary arteries to measure the response of the coronary artery internal diameter to acetylcholine. Healthy populations respond to acetylcholine by mild vasodilation and patients with endothelial dysfunction respond to acetylcholine by a diminished degree of dilation or even vasoconstriction. The method has the advantages of complex operation and high cost, and the angiography has certain side effect on human body, is not suitable for early diagnosis and follow-up observation of diseases, and has low social popularization.

The mainstream method in the market at present is to test the vascular endothelial function by observing Flow mediated vasodilation (FMD), the principle of FMD is to block the blood Flow in an artery (preferably brachial artery) by using a pressurizing means, release pressure after 5 minutes to allow the blood to circulate again, the shearing force of the circulated blood Flow to the blood vessel wall triggers the mechanism of vascular endothelial cells to release vascular dilating factors (nitric oxide), the vascular endothelial function of a subject is analyzed by observing the degree of dilation of the blood vessel, the larger the degree of dilation represents the better the endothelial function, and the blood vessel of the subject with endothelial dysfunction does not dilate. The method can realize non-invasive detection of vascular endothelial function, and two commercially available devices are introduced below.

One device is an ultrasonic FMD. The implementation steps of the equipment are as follows: the forearm part is pressurized to be higher than the systolic pressure by 60mmHg to block the blood flow by a cuff, the block is released after 5 minutes, and the diameter ratio of the brachial artery before block and after block is measured by using a precise color ultrasonic to evaluate the function of the vascular endothelium. The method has the advantages that the blood vessel is directly observed, the interference of human internal factors is small, but the method has the defects that professional operators are needed, and the observed quantity of the ultrasonic equipment is easily influenced by various external factors, such as cuff section, probe pressing pressure, external environment and the like, so that the function of the blood vessel endothelium cannot be stably and accurately analyzed, and larger errors exist.

Another device is to measure the amplitude change rate of finger tip tension pulse wave before and after brachial Artery occlusion by using a finger tip plethysmography device, namely Peripheral Artery Tonometry (PAT), and analyze the vascular endothelial function according to the magnitude of the change rate. Compared with an ultrasonic FMD (frequency modulated display), the ultrasonic FMD is simple and convenient to operate, but the purpose of accurately controlling the pressure is achieved because the plethysmography equipment is connected with the air pressure valve through the air pipe, so that the equipment structure is difficult to miniaturize, and the ultrasonic FMD is difficult to popularize for household use.

Combining some of the problems of the above two devices, how to detect the function of the vascular endothelium more simply, accurately, more widely and cheaply is a breakthrough in the modern cardiovascular field.

Disclosure of Invention

The utility model aims at overcoming the not enough of prior art, provide a vascular endothelial function check out test set based on elastic wire technique, this check out test set easy operation, the test is accurate, the low price, the early examination of the vascular endothelial function and the daily monitoring of specially adapted crowds.

In order to solve the technical problem, the utility model discloses vascular endothelial function check out test set's based on elasticity wire technique technical solution does:

the wireless finger stall unit comprises a sign sensor made of an elastic lead with variable resistance, a power supply module and a signal receiving and transmitting module I; the control terminal unit comprises a micro control unit MCU, a power supply module, a signal receiving and transmitting module II, a display screen, an air pump, an air pressure valve, a human-computer interaction interface and a pressurizing cuff.

The utility model discloses vascular endothelial function check out test set based on elasticity wire technique's technological effect lies in:

the utility model discloses a data acquisition of fingertip pulse wave is carried out to the elastic wire technique, with right wireless dactylotheca 1 and left wireless dactylotheca 2 cover on examinee's both hands finger, elastic wire 12 can produce certain pressure to the finger, the length variation of elastic wire 12 is driven in the beating of fingertip pulse, length variation leads to elastic wire 12 self resistance constantly change, the resistance value of change is collected in real time, signal reception transmission module carries out data conversion with these constantly changing resistance values, use signal reception transmission module to send these data to control terminal 3 in real time;

further, a signal receiving and transmitting module II in the control terminal 3 receives data sent by the right wireless finger cot 1 and the left wireless finger cot 2 in real time, converts the data into electric signals through the micro control unit MCU, displays the electric signals on the display screen 14 in real time, and prestores the collected data;

further, the micro control unit MCU controls the air pump to pressurize the pressurizing cuff 19, the air pressure valve acquires the pressurized air pressure value in real time, the brachial artery blockage of the subject is realized after the pressurized air pressure value reaches the specified air pressure value, the right wireless finger sleeve 1 and the left wireless finger sleeve 2 acquire pulse wave data of two fingertips under the condition of single-arm blockage in real time, and the control terminal 3 displays and prestores the data within the blockage time;

further, the micro control unit MCU controls the air pump to pressurize the cuff to release pressure, the right wireless finger sleeve 1 and the left wireless finger sleeve 2 acquire pulse wave data of two finger tips in real time after complete pressure release, and the control terminal 3 displays and prestores the data within a specified time after blocking;

further, the control terminal 3 integrates and operates the collected data in three periods of time, displays the vascular endothelial function value on the display screen 14, and uploads the data to the cloud server for storage in real time.

The utility model discloses the beneficial effect that can reach is:

compared with the existing pressure sensing technology and ultrasonic technology, the utility model has the advantages of simpler operation, higher automation degree, realization of one-man operation, more suitability for long-term monitoring of customers, and less influence on test results due to human factors;

compared with the pressure sensing technology, the utility model reduces the gas circuit module, reduces the signal interference and greatly reduces the production cost; compared with the ultrasonic technology, the method does not need to detect on the basis of expensive ultrasonic equipment or operate by a professional doctor, reduces equipment and labor cost, and is particularly suitable for early screening of the vascular endothelial function of large-scale people.

Drawings

The accompanying drawings, which are incorporated in and constitute a part of this specification, illustrate embodiments of the invention and, together with a general description of the context and the detailed description of the drawings, serve to explain the principles of the invention.

The invention will be described in further detail with reference to the following drawings and specific embodiments:

FIG. 1 is a practical operation diagram of the present invention;

FIG. 2 is a flow chart of the apparatus of the present invention;

FIG. 3 is a diagram of the structure of the wireless finger cot of the device of the present invention;

fig. 4 is a diagram of a characterization sensor system in a wireless finger cot of the device of the present invention;

fig. 5 is a control terminal outline view of the device of the present invention.

The reference numbers in the figures illustrate:

1 is a right wireless finger stall, 2 is a left wireless finger stall,

3 is a control terminal, 4 is an arm,

5 is a wireless finger sleeve shell, 6 is a sign sensor,

an indicator light 7, a charging hole 8,

9 is a control circuit board, 10 is an electrode plate,

11 is an insulated connecting device, 12 is an elastic lead,

13 is a human-computer interface, 14 is a display screen,

15 is a finger sleeve charging plug, 16 is a finger sleeve groove,

17 is a display terminal charging port, 18 is a control terminal shell,

reference numeral 19 denotes a compression cuff.

Detailed Description

The present invention will be described in detail with reference to the accompanying drawings:

one preferred embodiment is shown in fig. 3, 4 and 5, and the whole device is composed of three parts, wherein two wireless finger sleeves (fig. 3) and one control terminal (fig. 5) are included.

Wireless dactylotheca unit (fig. 3) includes wireless dactylotheca casing 5 and sign sensor 6, and signal acquisition module and signal reception transmission module one are integrated on control circuit board 9, contain the power in the wireless dactylotheca casing 5 and supply power for other modules, and wireless dactylotheca casing 5 outside leaves pilot lamp 7 and hole 8 that charges. Sign sensor 6 imbeds inside wireless dactylotheca casing 5, and it has the round hole to open on the wireless dactylotheca casing 5 and is used for holding tester's finger. The physical sign sensor (figure 4) is composed of a control circuit board 9, electrode plates 10, an insulating connecting device 11 and an elastic lead 12, wherein the resistance of the elastic lead 12 is monotonously related to the stress borne by the elastic lead, two ends of the elastic lead 12 are respectively connected with one end of each of the two electrode plates 10, the two electrode plates 10 are fixedly connected together by using the insulating connecting device 11, so that the elastic lead 12 forms a closed loop for accommodating fingers of a testee, the elastic lead 12 with a proper elastic coefficient can provide proper pre-tightening pressure for the fingers while accommodating the fingers with large volume difference, and the pre-tightening pressure can eliminate venous return fluctuation so as to enable pulse signals to be clearer and increase the accuracy of equipment. The insulation connecting device 11 can be a fixed connection or a movable latch device. The other two ends of the electrode plate 10 are connected with the control circuit board 9, the micro control unit MCU controls the acquisition module to acquire the change of the resistance of the elastic lead in the preset time, the change of the resistance of the elastic lead 12 reflects the tension change of the elastic lead 12, so that the pulse signals of the fingers of the testee are recorded, and the collected pulse wave signals are transmitted to the control terminal 3 through the signal receiving and transmitting module I.

The control terminal part (figure 5) comprises a control terminal shell 18 and a pressurizing cuff 19, the control terminal shell 18 is fixedly connected with the pressurizing cuff, the control terminal shell 18 contains a power supply, a signal receiving and transmitting module II, a wireless communication module and a micro control unit MCU, an air pump and an air pressure valve are also arranged inside the control terminal shell and communicated with the pressurizing cuff 19, and the micro control unit MCU can control the air pump to inflate and deflate the pressurizing cuff 19 at a proper time. The control terminal 3 receives the pulse wave signals sent by the right wireless finger cot 1 and the left wireless finger cot 2 and displays the pulse wave signals and the related results obtained through calculation on the display screen 14, and a subject can control the equipment through the human-computer interaction interface 13 on the control terminal 3. The wireless communication module can also upload the information of the testee and the data acquisition result to the cloud end, so that long-term data recording and remote monitoring are provided for the user. Control terminal casing 18 is opened outward has two dactylotheca recesses 16, has dactylotheca charging plug 15 in the recess, inserts right wireless dactylotheca 1 and left wireless dactylotheca 2 and can charge through dactylotheca charging plug 15 in the recess, and control terminal casing 18 still is equipped with display terminal charging mouth 17 outward, can charge for control terminal 3.

The vascular endothelial function detection method based on the elastic lead technology comprises the following steps (figure 2):

step 1: the right wireless finger cot 1 and the left wireless finger cot 2 are respectively sleeved on corresponding fingers of a hand of a testee, and the elastic lead 12 on the sign sensor 6 in the finger cot generates certain pressure on the fingers;

step 2: the physical sign sensor 6 collects pulse wave signals of a testee within a preset time, the signal receiving and transmitting module I transmits the pulse wave signals to the control terminal 3, and the control terminal 3 displays the received pulse wave signals on the display screen 14 in real time;

and step 3: an air pump in the control terminal 3 inflates the pressurizing cuff 19, the pressurizing cuff 19 blocks the blood flow of the brachial artery of one side of the upper limb for a period of time, and the right wireless finger cot 1 and the left wireless finger cot 2 collect pulse wave data of two fingertips under the blocking condition and transmit the pulse wave data to the control terminal 3 through the signal receiving and transmitting module I;

and 4, step 4: the air pump in the control terminal 3 releases air in the pressurizing cuff 19, the sign sensors 6 in the right wireless finger cot 1 and the left wireless finger cot 2 collect pulse wave signals after brachial artery blockage within preset time, and the pulse wave signals are transmitted to the control terminal through the first signal receiving and transmitting module;

and 5: and the control terminal 3 continues to receive the pulse wave signals after the interruption and displays the pulse wave signals in real time, and after the test is finished, the test data is analyzed and a diagnosis conclusion is obtained.

Preferably, the blocking time in step 3 is 5min, and the blocking pressure is the systolic blood pressure of the subject +60 mmHg.

The vascular endothelial function of the subject is analyzed by calculating the ratio of the amplitude of the pulse wave signal after the blockage to the amplitude of the pulse wave signal before the blockage (the analysis object is not limited to the amplitude, and can also be the area under the curve, etc.), wherein the larger the ratio is, the larger the vessel expansion is, the better the vascular endothelial function is. The whole process is automatically controlled and completed by the system except the wearable equipment and the information input.

It should be noted that the foregoing is only a preferred embodiment of the present invention and the technical principles applied. It will be understood by those skilled in the art that the present invention is not limited to the particular embodiments described herein, but is capable of various obvious modifications, rearrangements and substitutions as will now become apparent to those skilled in the art without departing from the scope of the invention. Therefore, although the present invention has been described in more detail with reference to the above embodiments, the present invention is not limited to the above embodiments, and may include other equivalent embodiments without departing from the spirit of the present invention, and the scope of the present invention is determined by the scope of the appended claims.

Claims

1. The utility model provides a vascular endothelial function check out test set, its includes a right side wireless dactylotheca (1), a left side wireless dactylotheca (2) and a control terminal (3), its characterized in that right side wireless dactylotheca (1) and left side wireless dactylotheca (2) have all contained wireless dactylotheca casing (5) and embedded sign sensor (6).

2. The vascular endothelial function detection device of claim 1, wherein the physical sign sensor (6) comprises electrode plates (10), an insulating connection device (11) and an elastic wire (12), two ends of the elastic wire (12) are respectively connected with one ends of the two electrode plates (10) to form a passage, the connection between the electrode plates (10) and the elastic wire (12) is fixedly connected together by using the insulating connection device (11), so that the elastic wire forms a closed loop for accommodating the finger of the subject, the other ends of the two electrode plates (10) of the physical sign sensor (6) are connected with the circuit board (9) in the wireless finger cot housing (5), and the physical sign sensor may comprise one or more elastic wires.

3. The vascular endothelial function detection device of claim 2, wherein the circuit board (9) is integrated with a signal acquisition module, a first signal receiving and transmitting module and a power supply module, the signal acquisition module converts the finger pulse wave signal of the subject into an electrical signal, and the signal is transmitted to the control terminal (3) through the first signal receiving and transmitting module.

4. The vascular endothelial function detection device of claim 1, wherein the control terminal (3) comprises a control terminal box body (18) and a pressurizing cuff (19), the control terminal box body (18) comprises a second signal receiving and transmitting module, a Micro Control Unit (MCU), a power module, an air pump and an air pressure valve inside, a man-machine interaction interface (13) and a display screen (14) are arranged outside the control terminal box body (18), the second signal receiving and transmitting module receives pulse wave signals from the right wireless cuff (1) and the left wireless cuff (2), and the MCU performs signal processing and displays the pulse wave signals and related test results on the display screen (14).

5. The device for detecting endothelial function of blood vessel according to claim 4, wherein the compression cuff (19) is connected to the air pump and the air pressure valve through the trachea, and the MCU detects the air pressure in the compression cuff (19) in real time through the air pressure valve and controls the air pump to inflate and deflate the compression cuff (19).