CN211358868U - Packaging hardware suitable for micro-fluidic chip - Google Patents
Packaging hardware suitable for micro-fluidic chip Download PDFInfo
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- CN211358868U CN211358868U CN201921993842.6U CN201921993842U CN211358868U CN 211358868 U CN211358868 U CN 211358868U CN 201921993842 U CN201921993842 U CN 201921993842U CN 211358868 U CN211358868 U CN 211358868U
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- cavity
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- microfluidic chip
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- 238000007789 sealing Methods 0.000 claims abstract description 54
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Abstract
The utility model discloses an encapsulating device suitable for micro-fluidic chip, be in including entrance point, exit end and setting sealed end between entrance point and the exit end, set up the sample chamber that link up its length direction in the entrance point, the lower part of entrance point has the last connecting portion that are used for being connected with the exit end, the exit end including be used for with go up the lower connecting portion that connecting portion carry out the connection and be used for going out the appearance pipe of appearance, go out in the appearance intraductal set up be used for with the appearance mouth that goes out of sample chamber intercommunication, offer on the lower connecting portion and be used for holding sealed end hold the chamber, sealed end includes gasket, sealing washer and micro-fluidic chip. The utility model discloses an encapsulation device, its structural design is reasonable, forms sealed end through encapsulating the micro-fluidic chip in the gasket to hold sealed end in the holding tank of exit end, the entrance point is connected with the exit end, makes the encapsulation process of micro-fluidic chip simple, does benefit to installation and detection, convenience of customers operation.
Description
Technical Field
The utility model belongs to the technical field of medical instrument, concretely relates to packaging hardware suitable for micro-fluidic chip.
Background
Currently, some target cells such as Circulating brain Tumor cells (CTC) are detected mainly by filtering and retaining the target cells through a filter membrane according to different Cell sizes or capturing the target cells through an immune recognition enrichment method. In the process of capturing and detecting an analyte in a sample by using the microfluidic chip, the steps of specifically capturing the analyte, removing interfering substances, marking the analyte, performing qualitative/quantitative analysis and the like are required.
The porous filter membrane method has the following disadvantages: 1. the pore size is single, and is not consistent with the diversity of the cell sizes of actual clinical patients, and the omission phenomenon exists; 2. the reagent consumption is large, and the later characterization is not easy to perform; 3. the blocking phenomenon is easy to occur, and the detection result is influenced; 4. the special filtering preparation process is complex and has high cost.
For example, patent application No. cn201620652899.x, entitled "chinese utility model patent of a micro-via chip-based tumor cell separation device" adopts micro-via chip to separate tumor cells, and screens the cells by size. The disadvantage is that the filter membrane is easily clogged, and the user risks contacting the biological sample during removal of the filter membrane from the filter plate module, possibly damaging the surface of the filter membrane, and having an irreversible effect on the captured analyte.
The immune recognition enrichment method mainly utilizes a micro-fluidic chip to combine magnetic beads/micro-columns for enrichment or modifies specific capture molecules on the surface of the chip for enrichment. One of the main problems of the existing microfluidic products is that the packaging is complicated, so that the processing cost is high, and the processing process is complex, thereby being not beneficial to the batch production and popularization of the microfluidic products.
Disclosure of Invention
In view of this, in order to solve the problems of the prior art, the present invention provides a packaging device suitable for a microfluidic chip, which has a simple packaging process.
In order to achieve the above purpose, the utility model adopts the following technical scheme:
the utility model provides an encapsulating device suitable for micro-fluidic chip, is in including entrance point, exit end and setting sealed end between entrance point and the exit end, set up the sample chamber that link up its length direction in the entrance point, the lower part of entrance point has the last connecting portion that are used for being connected with the exit end, the exit end including be used for with go up the lower connecting portion that connecting portion go on connecting and be used for going out the appearance pipe of appearance, go out in the appearance intraductal set up be used for with the appearance mouth that goes out of sample chamber intercommunication, set up on the lower connecting portion and be used for holding sealed end hold the chamber, sealed end includes gasket, sealing washer and micro-fluidic chip, set up the chip chamber that is used for holding micro-fluidic chip on the gasket, the upper portion and the sample chamber intercommunication in chip chamber, the lower part and the appearance mouth intercommunication in. The sample cavity is used for bearing a certain volume of sample or reagent to be measured.
In some embodiments of the present invention, the microfluidic chip may employ one or more multi-channel mesh substrates arranged in parallel, the substrate comprising a plurality of intersecting mesh wires, and the surface having a capture layer for specifically capturing the analyte. The capture layer comprises capture objects, such as antibodies, DNA, polypeptides and the like, which can be specifically combined with target cells or biomolecules, so that the problem of internal blockage is avoided. The surface of one or more multi-pore net-shaped substrates in the device can be modified with the same capture layer or different capture layers. The capture rate of specific analytes can be improved by modifying the reticular matrixes of the same capture layer in a plurality of layers, and the detection flux can be improved by modifying the reticular matrixes of different capture layers, so that the simultaneous detection of a plurality of analytes can be realized. The connection between the capture layer and the porous channel network matrix can be broken by the action of a specific substance (such as lyase), so that the captured analyte can be collected at the outlet of the microfluidic chip for detection and further analysis.
According to some preferred aspects of the invention, the lower part of the inlet end has a pressing table extending to the containing chamber, the sealing end and the pressing table being provided with an upper sealing ring therebetween. Through setting up the pressure platform, can tightly fix the sealed end in holding the intracavity.
Preferably, the sealing end comprises a plurality of gaskets, and the depth of the accommodating cavity is matched with the sum of the total thickness of the plurality of gaskets and the height of the pressing platform. The gasket is used for fixedly placing the chip and the sealing ring, the flowing state of the sample in the chamber can be changed by optimizing the thickness of the gasket and/or changing the number of the gaskets, and the sealing function is achieved.
According to some preferred implementation aspects of the utility model, the outer wall of lower connecting portion is provided with the external screw thread, it is used for holding to offer on the last connecting portion the connection chamber of lower connecting portion, be provided with on the inner wall in connection chamber with external screw thread matched with internal thread. Quick connection between the inlet end and the outlet end is achieved through the external threads and the internal threads, effective sealing is achieved between the upper sealing ring and the lower sealing ring and the sealing end through the thread pretightening force of the inlet end and the outlet end, and the liquid leakage phenomenon is prevented from occurring in the operation process.
According to some preferred implementation aspects of the utility model, the bottom of sealed end with still be provided with the lower seal circle between the exit end, the lower part that holds the chamber is seted up and is used for holding the seal groove of lower seal circle.
According to some preferred implementation aspects of the utility model, the slot has been seted up to the periphery of gasket, the ditch inslot is provided with the sealing washer. In some embodiments, the groove is preferably arranged at the upper part of the periphery of the gasket, so that sealing structures are arranged between adjacent gaskets, between the uppermost gasket and the pressing platform and between the lowermost gasket and the accommodating cavity, and sealing is effectively realized.
According to some preferred implementation aspects of the present invention, the inner wall of the sample chamber top is provided with a groove along its circumferential direction for connection with an instrument. The annular groove and the inner wall of the sample cavity with a certain gradient can realize the fastening and sealing with a mechanical arm of the instrument, the whole device is moved through the mechanical arm, and the flow direction of the sample/reagent in the micro-fluidic chip is driven through an air path in the mechanical arm.
According to some preferred implementation aspects of the present invention, the cross sectional area of the sample chamber is gradually reduced from top to bottom, and the cross sectional area of the sample outlet is gradually reduced from top to bottom.
According to some preferred implementation aspects of the present invention, the inlet end, the sealing end and the outlet end are coaxially disposed, and the sample chamber, the chip chamber and the sample outlet are coaxially connected to form a channel for the sample or the reagent to flow in or out.
According to some preferred implementation aspects of the present invention, the outer wall of the upper connecting portion is provided with a protruding strip extending in the thickness direction of the upper connecting portion, and the protruding strip is uniformly distributed on the outer wall of the upper connecting portion. The friction force is effectively increased by the arrangement of the convex strips, and the device is convenient to take and disassemble.
Compared with the prior art, the utility model discloses an useful part lies in: the utility model discloses an encapsulating device suitable for micro-fluidic chip, its structural design is reasonable, through forming sealed end with micro-fluidic chip encapsulation in the gasket to hold sealed end in the holding tank of exit end, the entrance point is connected with the exit end, makes micro-fluidic chip's packaging process simple, does benefit to installation and detection, and convenience of customers operates, also can save sample quantity and check-out time simultaneously, improves and detects the flux.
Drawings
In order to more clearly illustrate the technical solutions in the embodiments of the present invention, the drawings needed to be used in the description of the embodiments will be briefly described below, and it is obvious that the drawings in the following description are only some embodiments of the present invention, and it is obvious for those skilled in the art to obtain other drawings without creative efforts.
Fig. 1 is a schematic cross-sectional view of a packaging device suitable for a microfluidic chip according to a preferred embodiment of the present invention;
wherein: the device comprises an inlet end-1, a sample cavity-11, an upper connecting part-12, an internal thread-13, a groove-14, a pressing table-15, a reinforcing plate-16, an upper sealing ring-17, a gasket-21, a sealing ring-22, a microfluidic chip-23, an outlet end-3, a lower connecting part-31, a sample outlet pipe-32, an external thread-33, a sample outlet-34 and a lower sealing ring-35.
Detailed Description
In order to make the technical solution of the present invention better understood, the technical solution of the present invention will be clearly and completely described below with reference to the accompanying drawings in the embodiments of the present invention, and it is obvious that the described embodiments are only some embodiments of the present invention, not all embodiments. Based on the embodiments in the present invention, all other embodiments obtained by a person skilled in the art without creative efforts shall belong to the protection scope of the present invention.
Referring to fig. 1, the packaging device for the microfluidic chip 23 of the present embodiment includes an inlet end 1, an outlet end 3, and a sealing end disposed between the inlet end 1 and the outlet end 3.
Wherein, the inlet end 1 is internally provided with a sample cavity 11 running through the length direction thereof, the lower part of the inlet end 1 is provided with an upper connecting part 12 connected with the outlet end 3, the outlet end 3 comprises a lower connecting part 31 connected with the upper connecting part 12 and a sample outlet pipe 32 used for sample outlet, and the sample outlet pipe 32 is internally provided with a sample outlet 34 used for being communicated with the sample cavity 11. The lower connecting portion 31 has a receiving cavity formed therein for receiving the sealing end.
In this embodiment, the lower portion of the inlet end 1 further has a pressing platform 15 extending to the accommodating chamber, an upper sealing ring 17 is disposed between the sealing end and the pressing platform 15, and the pressing platform 15 is disposed to tightly fix the sealing end in the accommodating chamber. The outer wall of lower connecting portion 31 in this embodiment is provided with external screw thread 33, offers the connection chamber that is used for holding lower connecting portion 31 on the upper connecting portion 12, is provided with on the inner wall in connection chamber with external screw thread 33 complex internal thread 13. Still be provided with lower seal ring 35 between the bottom of seal end and exit end 3, the seal groove that is used for holding lower seal ring 35 is seted up to the lower part of connecting the chamber, effectively realizes sealedly through upper and lower seal ring 35.
The sealing end comprises a gasket 21, a sealing ring 22 and a microfluidic chip 23, the gasket 21 is used for bearing the sealing ring 22 and the microfluidic chip 23, a chip cavity for containing the microfluidic chip 23 is formed in the gasket 21, the upper portion of the chip cavity is communicated with the sample cavity 11, and the lower portion of the chip cavity is communicated with the sample outlet 34. The sample chamber 11 is used for carrying a certain volume of sample or reagent to be measured. The inlet end 1, the sealing end and the outlet end 3 are coaxially arranged, so that the sample cavity 11, the chip cavity and the sample outlet 34 are coaxially communicated up and down to form a channel for the inflow or outflow of a sample or a reagent. The cross-sectional area of the sample chamber 11 is gradually reduced from top to bottom, and the cross-sectional area of the sample outlet 34 is gradually reduced from top to bottom.
As shown in fig. 1, the sealing end in this embodiment includes a plurality of gaskets 21 stacked together, the gasket 21 is used for fixedly placing a chip and a sealing ring 22, a groove is opened on the periphery of the gasket 21, the sealing ring 22 is disposed in the groove, and the groove is preferably opened on the upper portion of the periphery of the gasket 21, so that finally, sealing structures are provided between adjacent gaskets 21, between the uppermost gasket 21 and the platen 15, and between the lowermost gasket 21 and the accommodating cavity, thereby effectively achieving sealing. And the quick connection between the inlet end 1 and the outlet end 3 is realized through the external threads 33 and the internal threads 13, and the effective sealing between the sealing rings 17, 22 and 35 and each component is realized through the thread pretightening force of the inlet end 1 and the outlet end 3, so that the leakage phenomenon in the operation process is prevented.
To better secure the sealed end within the receiving cavity, the depth of the receiving cavity is slightly less than the sum of the thickness of the plurality of spacers 21 plus the height of the platen 15. The flow conditions of the sample inside the chamber can be changed by optimizing the thickness of the gasket 21 and/or changing the number of gaskets 21, while acting as a seal. The sealed end in this embodiment comprises 3 shims 21 stacked one above the other.
The microfluidic chip 23 in this embodiment is one or more multi-channel mesh substrates arranged in parallel, and the substrate is composed of a plurality of intersecting mesh wires, and the surface of the substrate is provided with a capture layer capable of specifically capturing an analyte. The capture layer comprises capture objects, such as antibodies, DNA, polypeptides and the like, which can be specifically combined with target cells or biomolecules, so that the problem of internal blockage is avoided. The surface of one or more porous channel net-shaped substrates in the chip can be modified with the same capture layer or different capture layers. The capture rate of specific analytes can be improved by modifying the reticular matrixes of the same capture layer in a plurality of layers, and the detection flux can be improved by modifying the reticular matrixes of different capture layers, so that the simultaneous detection of a plurality of analytes can be realized. The connection between the capture layer and the porous channel network matrix can be broken by a specific substance (such as lyase), so that the captured analyte can be collected at the outlet of the microfluidic chip 23 for detection and further analysis.
The inner wall of the top of the sample chamber 11 is provided with a groove 14 along the circumferential direction for connecting with an instrument. The circumferential groove 14 and the inner wall of the sample cavity 11 with a certain slope can realize the fastening and sealing with the mechanical arm of the instrument, the whole device is moved by the mechanical arm, and the flow direction of the sample/reagent inside the microfluidic chip 23 is driven by the air path inside the mechanical arm.
A reinforcing plate 16 is also provided between the upper connecting portion 12 and the outer wall of the sample chamber 11 to enhance the overall strength of the inlet end 1. In addition, the outer wall of the upper connecting portion 12 in this embodiment is provided with protruding strips (not shown) extending along the thickness direction of the upper connecting portion 12, and the protruding strips are uniformly distributed on the outer wall of the upper connecting portion 12 at intervals. The friction force is effectively increased by the arrangement of the convex strips, and the device is convenient to take and disassemble. The arrangement of the convex strips is similar to that of the beverage bottle cap.
The assembly steps for packaging the microfluidic chip 23 by using the packaging device of this embodiment are as follows:
1. the lower sealing ring 35 is placed in a sealing groove of the accommodating cavity of the outlet end 3;
2. a sealing ring 22 is sleeved in a groove on the periphery of the gasket 21, and a microfluidic chip 23 formed by one or more layers of porous channel net-shaped substrates is placed in a chip cavity of the gasket 21;
3. three gaskets 21 with sealing rings 22 and microfluidic chips 23 are sequentially stacked and placed in the accommodating cavity of the outlet end 3;
4. the assembly is completed by screwing the inlet end 1 and the outlet end 3 together by the internal thread 13 on the upper connecting part 12 of the inlet end 1 and the external thread 33 on the lower connecting part 31 of the outlet end 3, so that the lower connecting part 31 is located in the connecting cavity of the upper connecting part 12.
The packaging device in this embodiment packages the microfluidic chip 23 to obtain a product which is subsequently used for capturing target cells of a patient's blood sample such as circulating tumor cells and realizing an immunofluorescence staining function, and then the product can be transferred to a fluorescence microscope to observe and count the captured circulating tumor cells; or the captured analyte can be eluted from the porous mesh matrix and then qualitatively/quantitatively analyzed after being collected at the outlet.
The packaging device of the embodiment has a simple overall structure, and can be produced in batch by injection molding; the materials may also be chosen from Polyethylene (PE), polypropylene (PP), polyvinyl chloride (PVC), Polystyrene (PS), acrylonitrile-butadiene-styrene copolymer (ABS), etc.
The packaging device in the embodiment is regular in design and beneficial to processing; the number of parts is small, the assembly mode is simple, the operation is convenient, and errors in the assembly process can be avoided; through the structural design of the gasket, the dual functions of bearing the chip and the sealing ring and optimizing the internal flow of the cavity are realized; the detection operation flow is simple, the sample consumption is saved, and the detection flux is improved.
The above embodiments are only for illustrating the technical concept and features of the present invention, and the purpose thereof is to enable those skilled in the art to understand the contents of the present invention and to implement the present invention, so as not to limit the protection scope of the present invention, and all equivalent changes or modifications made according to the spirit of the present invention should be covered by the protection scope of the present invention.
Claims (10)
1. A packaging device suitable for a microfluidic chip is characterized by comprising an inlet end, an outlet end and a sealing end arranged between the inlet end and the outlet end, the inlet end is internally provided with a sample cavity running through the length direction of the inlet end, the lower part of the inlet end is provided with an upper connecting part used for being connected with the outlet end, the outlet end comprises a lower connecting part used for being connected with the upper connecting part and a sample outlet pipe used for discharging samples, a sample outlet communicated with the sample cavity is arranged in the sample outlet pipe, an accommodating cavity for accommodating the sealing end is arranged on the lower connecting part, the sealing end comprises a gasket, a sealing ring and a microfluidic chip, a chip cavity for accommodating the microfluidic chip is formed on the gasket, the upper part of the chip cavity is communicated with the sample cavity, and the lower part of the chip cavity is communicated with the sample outlet.
2. The packaging device for the microfluidic chip as claimed in claim 1, wherein the lower portion of the inlet end has a pressing platform for extending to the accommodating cavity, and an upper sealing ring is disposed between the sealing end and the pressing platform.
3. The packaging device for the microfluidic chip as claimed in claim 2, wherein the sealing end comprises a plurality of pads, and the depth of the accommodating cavity matches with the sum of the total thickness of the pads and the height of the platen.
4. The packaging device for the microfluidic chip according to claim 1, wherein the outer wall of the lower connecting portion is provided with an external thread, the upper connecting portion is provided with a connecting cavity for accommodating the lower connecting portion, and the inner wall of the connecting cavity is provided with an internal thread matched with the external thread.
5. The packaging device for the microfluidic chip according to claim 1, wherein the gasket has a groove formed on an outer circumference thereof, and a sealing ring is disposed in the groove.
6. The packaging device suitable for the microfluidic chip according to claim 1, wherein a lower sealing ring is further disposed between the bottom of the sealing end and the outlet end, and a sealing groove for accommodating the lower sealing ring is formed at a lower portion of the accommodating cavity.
7. The packaging device for the microfluidic chip according to claim 1, wherein the inner wall of the top of the sample chamber is provided with a groove along the circumferential direction for connecting with an instrument.
8. The packaging device of claim 1, wherein the cross-sectional area of the sample chamber is gradually reduced from top to bottom, and the cross-sectional area of the sample outlet is gradually reduced from top to bottom.
9. The packaging device for the microfluidic chip according to claim 1, wherein the inlet end, the sealing end and the outlet end are coaxially disposed.
10. The packaging device for the microfluidic chip according to any one of claims 1 to 9, wherein the outer wall of the upper connecting portion is provided with ribs extending along the thickness direction of the upper connecting portion, and the ribs are uniformly spaced on the outer wall of the upper connecting portion.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201921993842.6U CN211358868U (en) | 2019-11-18 | 2019-11-18 | Packaging hardware suitable for micro-fluidic chip |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201921993842.6U CN211358868U (en) | 2019-11-18 | 2019-11-18 | Packaging hardware suitable for micro-fluidic chip |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN211358868U true CN211358868U (en) | 2020-08-28 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201921993842.6U Expired - Fee Related CN211358868U (en) | 2019-11-18 | 2019-11-18 | Packaging hardware suitable for micro-fluidic chip |
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| Country | Link |
|---|---|
| CN (1) | CN211358868U (en) |
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2019
- 2019-11-18 CN CN201921993842.6U patent/CN211358868U/en not_active Expired - Fee Related
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Granted publication date: 20200828 |