CN211357441U - Pulse generating circuit and tumor treatment device - Google Patents

Pulse generating circuit and tumor treatment device Download PDF

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CN211357441U
CN211357441U CN201921871707.4U CN201921871707U CN211357441U CN 211357441 U CN211357441 U CN 211357441U CN 201921871707 U CN201921871707 U CN 201921871707U CN 211357441 U CN211357441 U CN 211357441U
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voltage
pulse generating
processor
pulse
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王海峰
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Shanghai Ruidao Medical Technology Co ltd
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Remedicine Co ltd
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Abstract

The application provides a pulse generating circuit and a tumor treatment device. The pulse generating circuit comprises a main control panel, an RS485 interface chip, a power supply unit, a pulse generating unit and a switching unit; the pulse generating unit is provided with a first processor, and the switching unit is provided with a second processor; the first UART port of the main control panel is connected with the input end of the RS485 interface chip, and the output end of the RS485 interface chip is respectively connected with the first processor and the second processor through an RS485 bus; the second UART port of the main control board is connected with the power supply unit and is used for controlling the power supply unit to generate high-voltage direct current voltage; the pulse generating unit is used for receiving the high-voltage direct-current voltage from the power supply unit and converting the high-voltage direct-current voltage into a bipolar pulse voltage; the switching unit is used for receiving the bipolar pulse voltage from the pulse generating unit and outputting the bipolar pulse voltage to the corresponding electrode needle. Through pulse generation circuit and tumour treatment device of this application embodiment, simplified the connection structure between each plate, improved the interference killing feature, be convenient for maintain moreover.

Description

Pulse generating circuit and tumor treatment device
Technical Field
The application relates to the field of medical instruments, in particular to a pulse generating circuit and a tumor treatment device.
Background
Cancer is a major disease that endangers human health. Traditional therapies for tumors and recently developed physical therapies for thermal ablation characterized by minimally invasive ablation have certain limitations in their clinical applications due to limitations of indications, contraindications, side effects of treatment, thermal effects, and the like. In recent years, with the development of pulsed bioelectricity, electric field pulses have attracted researchers' attention due to their non-thermal, minimally invasive biomedical effects, and are gradually applied to clinical treatment of tumors.
The principle of electric field pulse therapy for tumor is that high-voltage ultrashort nanosecond pulse is generated by a high-voltage power supply and a pulse generator, ultrashort pulse with certain frequency is emitted, electric energy is released in the form of pulse electric field through an electrode, and electric field energy is transmitted to tumor tissue through an electrode needle to enable tumor cells to generate irreversible electroporation and apoptosis.
The pulse generating circuit in the prior art adopts the concurrent control of the traditional IO ports, the number of the IO ports is large, the connection is complex, the anti-interference capability is poor, the maintenance is difficult, and the like.
Disclosure of Invention
The application provides a pulse generating circuit and a tumor treatment device.
According to a first aspect of the embodiments of the present application, there is provided a pulse generation circuit applied to a tumor treatment apparatus including an electrode needle, the pulse generation circuit including: the device comprises a main control panel, an RS485 interface chip, a power supply unit, a pulse generation unit and a switching unit; the pulse generating unit is configured with a first processor, and the switching unit is configured with a second processor; the first UART port of the main control panel is connected with the input end of the RS485 interface chip, and the output end of the RS485 interface chip is respectively connected with the first processor and the second processor through an RS485 bus; the second UART port of the main control board is connected with the input end of the power supply unit and is used for controlling the power supply unit to generate high-voltage direct-current voltage and outputting the high-voltage direct-current voltage to the pulse generating unit; the input end of the pulse generating unit is connected with the output end of the power supply unit, and the pulse generating unit is responsive to the first processor and is used for receiving the high-voltage direct current voltage, converting the high-voltage direct current voltage into a bipolar pulse voltage and outputting the bipolar pulse voltage to the switching unit; the input end of the switching unit is connected with the output end of the pulse generating unit, and the switching unit is responsive to the second processor and is used for receiving the bipolar pulse voltage and outputting the bipolar pulse voltage to the corresponding electrode needle.
Further, the pulse generating circuit further includes: an emergency stop unit; the emergency stop unit comprises a third processor and an emergency stop switch; the output end of the RS485 interface chip is connected with the third processor through the RS485 bus; the emergency stop unit is connected between the power supply unit and the pulse generation unit; the emergency stop unit is responsive to the third processor to cut off an energy input receiving the high voltage dc voltage from the power supply unit and cut off a capability output outputting the high voltage dc voltage to the pulse generating unit and release energy when the emergency stop switch is turned on.
Further, the pulse generating circuit further includes: a first isolation unit; the first isolation unit is connected between the first UART port and the input end of the RS485 interface chip.
Further, the pulse generating circuit further includes: a second isolation unit; the second isolation unit is connected between the second UART port and the input end of the power supply unit.
Further, the switching unit comprises at least 2 switching channels, and each switching channel comprises a single-pole double-throw switch and a single-pole single-throw switch; two fixed ends of the single-pole double-throw switch are respectively connected with a positive polarity pulse voltage end and a negative polarity pulse voltage end of the bipolar pulse voltage; the common end of the single-pole double-throw switch is connected to the electrode needle through the single-pole single-throw switch; the enabling ends of the single-pole double-throw switch and the single-pole single-throw switch are respectively connected with the second processor.
Further, there are 8 switching channels.
Further, the main control board is built by an STM32F2 chip.
Further, the first processor, the second processor, and the third processor are all ARMCortex-M3 processors.
Further, the RS485 interface chip adopts a chip with model number SN65LBC176A series.
According to a second aspect of embodiments of the present application there is provided a tumour therapy device comprising: at least 2 electrode needles, an upper computer and the pulse generating circuit; the upper computer is connected with the main control board through a serial port; the electrode needle is connected with the output end of the switching unit.
The pulse generation circuit and the tumor treatment device adopt a topological structure of an RS485 master-slave network, and the master control board is connected with other slave function boards (a pulse generation unit and a switching unit) through an RS485 serial bus. And each slave function board is independently provided with a processor and can work independently, and the master control board can control the slave function boards to work cooperatively through an RS485 network. Compared with the prior art in which the main control board concurrently controls other functional boards through the IO port, the connection interfaces are reduced, the wiring is simple, and the connection structure between the boards is greatly simplified. And the RS485 network adopts a differential mode to transmit signals, so that the anti-interference capability is improved and the response speed can be effectively improved compared with the concurrent control of the IO port in the prior art. In addition, when a new slave function board needs to be added, the slave function board is directly connected to the RS485 bus in series, and the method is simple and convenient. When the fault is maintained, only the functional board with the fault can be maintained, and the system maintenance is facilitated.
It is to be understood that both the foregoing general description and the following detailed description are exemplary and explanatory only and are not restrictive of the application.
Drawings
The accompanying drawings, which are incorporated in and constitute a part of this specification, illustrate embodiments consistent with the present application and together with the description, serve to explain the principles of the invention.
FIG. 1 is a schematic diagram of a pulse generation circuit according to an exemplary embodiment of the present application;
fig. 2 is a schematic diagram of a pulse generating unit according to an exemplary embodiment of the present application;
fig. 3 is a schematic structural diagram of a switching unit according to an exemplary embodiment of the present application;
FIG. 4 is a schematic diagram of another pulse generation circuit shown in an exemplary embodiment of the present application;
FIG. 5 is a schematic diagram of an emergency stop unit according to an exemplary embodiment of the present application;
FIG. 6 is a schematic diagram of yet another pulse generation circuit shown in an exemplary embodiment of the present application;
fig. 7 is a schematic structural diagram of a tumor treatment apparatus according to an exemplary embodiment of the present application.
Detailed Description
Reference will now be made in detail to the exemplary embodiments, examples of which are illustrated in the accompanying drawings. When the following description refers to the accompanying drawings, like numbers in different drawings represent the same or similar elements unless otherwise indicated. The embodiments described in the following exemplary embodiments do not represent all embodiments consistent with the present application. Rather, they are merely examples of apparatus and methods consistent with certain aspects of the present application, as detailed in the appended claims.
The terminology used herein is for the purpose of describing particular embodiments only and is not intended to be limiting of the application. As used in this application and the appended claims, the singular forms "a", "an", and "the" are intended to include the plural forms as well, unless the context clearly indicates otherwise.
It is to be understood that although the terms first, second, third, etc. may be used herein to describe various information, such information should not be limited to these terms. These terms are only used to distinguish one type of information from another. For example, first information may also be referred to as second information, and similarly, second information may also be referred to as first information, without departing from the scope of the present application. The word "if" as used herein may be interpreted as "at … …" or "when … …" or "in response to a determination", depending on the context.
Fig. 1 is a schematic diagram of a pulse generating circuit 10 according to an embodiment. The pulse generating circuit 10 is applied to a tumor treatment apparatus including an electrode needle. The pulse generating circuit 10 includes a main control board 1, an RS485 interface chip 2, a power supply unit 3, a pulse generating unit 4, and a switching unit 5. The pulse generating unit 4 is provided with a first processor 41 and the switching unit 5 is provided with a second processor 51. The first UART port 11 of the main control panel 1 is connected with the input end of the RS485 interface chip 2, and the output end of the RS485 interface chip 2 is respectively connected with the first processor 41 and the second processor 51 through an RS485 bus; the second UART port 12 of the main control board 1 is connected to the input terminal of the power supply unit 3, and is used for controlling the power supply unit 3 to generate a high-voltage direct current voltage and outputting the high-voltage direct current voltage to the pulse generating unit 4; an input end of the pulse generating unit 4 is connected with an output end of the power supply unit 3, and the pulse generating unit 4 is responsive to the first processor 41 and is used for receiving the high-voltage direct current voltage, converting the high-voltage direct current voltage into a bipolar pulse voltage and outputting the bipolar pulse voltage to the switching unit 5; the input end of the switching unit 5 is connected to the output end of the pulse generating unit 4, and the switching unit 5 is responsive to the second processor 51, and is configured to receive the bipolar pulse voltage and output the bipolar pulse voltage to the corresponding electrode needle 20.
Specifically, in the embodiment of the present application, the main control board 1 is implemented at least partially by digital electronic circuits, analog electronic circuits, or computer hardware, firmware, software, or a combination thereof. In an optional embodiment, the function of the main control board 1 may be completed by a single chip microcomputer, and optionally, the main control board may be constructed by an STM32F2 series chip, such as a chip with a model number of STM32F207VCT 6. The STM32F2 serial single chip microcomputer is loaded with an ARM Cortex-M3 kernel, and a real-time flash accelerator can be adapted to enable the STM32F2 to execute codes on an on-chip flash memory at a high speed of 120MHz and in a zero-waiting mode, so that the performance advantage of an ARMCortex-M3 kernel can be played to the maximum.
In this embodiment, the first UART port 11 and the second UART port 12 of the main control board 1 both use TTL levels, that is, the low level (0V level) is 0, and the high level (+5V level) is 1, and transmit data in an asynchronous communication manner. The RS485 communication uses a differential signal transmission method, also called balanced transmission, and uses a pair of twisted pair wires, one of which is defined as a and the other as B. The logic '1' is represented by the voltage difference between two lines being + (2-6) V; a logical "0" is represented by a voltage difference between two lines of- (2 to 6) V. The RS485 interface chip 2 is mainly used for level conversion, and converts a signal output from the first UART port 11 into data suitable for RS485 network transmission. Optionally, the RS485 interface chip 2 may adopt an SN65LBC176A series chip, and the chip adopts a combination of a balanced driver and a differential receiver, so that the common-mode interference resistance is enhanced, and the noise interference resistance is good.
In the embodiment of the application, the RS485 communication network adopts a bus type topological structure, 128 or 256 nodes can be connected to the same bus at most, and 400 nodes can be supported to the maximum. In the present embodiment, the master control board 1 serves as a master function board, the pulse generating unit 4 and the switching unit 5 serve as slave function boards, and the master control board 1 is connected to the slave function boards (the pulse generating unit 4 and the switching unit 5) through an RS485 serial bus, thereby controlling the slave function boards to operate cooperatively. Each slave function board is individually configured with a processor so that each slave function board can operate independently. In an alternative embodiment, the first processor 41 and the second processor 51 can both adopt an ARM Cortex-M3 processor to perform logic control and current-voltage signal acquisition, and feed the acquired current-voltage signal back to the main control board 1 through an RS485 network. So that the main control board 1 can collect the working state, current and voltage parameters and the like of each slave function board.
In an alternative embodiment, the main control board 1 may be connected to the power supply unit 3 through an RS232 serial line. Specifically, the second UART port 12 of the main control board 1 may be connected to the power supply unit 3 through the RS232 interface chip 6, referring to fig. 1. The RS232 interface chip 6 is mainly used for level conversion, so that the signal coming out of the second UART port 12 can be transmitted through the RS232 serial line. Of course, the main control board 1 may be connected to the power supply unit 3 by other connection means.
The power supply unit 3 in the embodiment of the present application is used to supply power to the respective units of the pulse generating circuit 10. The power supply unit 3 may comprise, for example, a mains supply, a main switch, a power filter, a switching power supply module and a high voltage direct current power supply module. The switching power supply module may include a transformer and rectifier device, for example, to convert a 220V/50Hz ac input to a 12V dc output. The high voltage dc power supply module may generate a required high voltage dc voltage based on a command of the main control board 1. For example, an ac mains voltage of 220V is converted to a dc voltage of 800V to 3000V. In other examples, the high voltage dc power supply module may also convert the ac mains voltage to generate a dc voltage below 800V, such as 300V, 400V, 500V, 600V or 700V.
The pulse generating unit 4 in the embodiment of the present application receives the high-voltage dc voltage from the power supply unit 3 based on an instruction of the first processor 41, and converts the high-voltage dc voltage into a bipolar pulse voltage (including a positive polarity pulse voltage and a negative polarity pulse voltage). In one embodiment, the pulse generating unit 4 may be an IGBT full bridge circuit, as shown in fig. 2. The high voltage direct current voltage received by the pulse generating unit 4 is subjected to current sampling by the current sensor 42, then converted by the ADC analog-to-digital converter 43, and then converted into a bipolar pulse voltage by the IGBT full bridge circuit to be output to the switching unit 5. In an alternative embodiment, the pulse generating unit 4 may further include a foot switch S1, and the foot switch S1 is connected between the output terminal of the pulse generating unit 4 and the input terminal of the converting unit 5, so as to switch off or switch on the output of the bipolar pulse voltage more conveniently.
In an alternative embodiment, the switching unit 5 comprises at least 2 switching channels, each switching channel comprising a single pole double throw switch 52 and a single pole single throw switch 53. Please refer to fig. 3 (fig. 3 illustrates 2 switching channels as an example). In an alternative embodiment, the single pole, double throw switch 52 and the single pole, single throw switch 53 are both relay switches. Two fixed ends of the single-pole double-throw switch 52 are respectively connected with a positive polarity pulse voltage end and a negative polarity pulse voltage end of the bipolar pulse voltage output by the pulse generating unit 4. The common terminal of the single pole double throw switch 52 is connected to the electrode pin 20 through a single pole single throw switch 53. The enable terminals of the single-pole double-throw switch 52 and the single-pole single-throw switch 53 are both connected to the second processor 51, the single-pole double-throw switch 52 is used for selecting the polarity of the pulse voltage, and the single-pole single-throw switch 53 is used for controlling the output of the pulse. In this embodiment, at least 2 switching channels of the switching channels are turned on simultaneously, that is: one of the switching channels outputs a positive polarity pulse voltage, and the other outputs a negative polarity pulse voltage. Similarly, the number of the electrode needles 20 in this embodiment is at least 2, and one of them outputs a pulse voltage with positive polarity, and the other outputs a pulse voltage with negative polarity. The electrode needles 20 are used to be applied to tumor tissue of a human body, so that a high voltage electric field is formed between the electrode needles 20 on the tumor tissue.
Optionally, there are 8 switching channels in the present embodiment, and the output end of each switching channel is connected to one electrode needle 20. More electrode needles 20 may be selected based on the type of tumor to be targeted, shape, size, malignancy, etc. For example, 8 electrode needles 20 may be selected, of which 4 output positive polarity pulse voltages and the other 4 output negative polarity pulse voltages. In another example, 4, 5, or 7 electrode needles 20 may be selected, and the polarities of the pulse voltages output from the selected electrode needles 20 are different.
In the present embodiment, when the polarity of the pulse voltage is selected by using the single-pole double-throw switch 52, either the positive polarity pulse voltage or the negative polarity pulse voltage is selected, and the phenomenon that the positive and negative polarity pulse voltages are simultaneously turned on does not occur, so that the output short circuit can be avoided.
In another alternative embodiment, referring to fig. 4, the pulse generating circuit 10 may further include an emergency stop unit 7, the emergency stop unit 7 being connected between the power supply unit 3 and the pulse generating unit 4, the emergency stop unit 7 including a third processor 71 and an emergency stop switch 72. The output end of the RS485 interface chip 2 is connected with the third processor 71 through an RS485 bus; the third processor 71 can also adopt arm port-M3 to perform logic control and current-voltage signal acquisition, and feed back the acquired current-voltage signal to the main control panel 1 through an RS485 network.
In an optional embodiment, the emergency stop unit 7 may further include a switch K1, a switch K2, a capacitor C1, a discharge switch K3, a discharge resistor R1, a voltage dividing resistor R2, and a voltage dividing resistor R3. As shown in fig. 5. The capacitor C1 is connected in parallel to the output end of the high voltage dc power module of the power unit 3 for storing electric energy, the emergency stop unit 7 responds to the third processor 71, when the emergency stop switch 72 is turned on (for example, a mechanical button is pressed), the energy input receiving the high voltage dc voltage from the power unit 3 is cut off by the off switch K1, the energy output outputting the high voltage dc voltage to the pulse generating unit 4 is cut off by the off switch K2, and the energy stored in the capacitor C1 is released by closing the discharge switch K3 and turning on the discharge resistor R1, thereby achieving the purpose of voltage reduction and discharge. In addition, the voltage dividing resistor R2 and the voltage dividing resistor R3 may divide the high voltage into low voltages and input the low voltages to the third processor 71, so that the third processor 71 may collect the current and voltage signals.
In another alternative embodiment, as shown in fig. 6, the pulse generating circuit 10 may further include a first isolating unit 8, and the first isolating unit 8 is connected between the first UART port 11 and the input terminal of the RS485 interface chip 2. In another alternative embodiment, the pulse generating circuit 10 may further include a second isolating unit 9, and with continued reference to fig. 6, the second isolating unit 9 is connected between the second UART port 12 and the input terminal of the power supply unit 3. The first isolation unit 8 and the second isolation unit 9 may each include an isolation transformer and a photo isolator, and the isolation transformer is mainly used for electrical isolation, so that control circuits on the primary side and the secondary side are not interfered. The photoelectric isolator performs electric-optical-electric conversion on the received signals, isolates an interference source and an easily interfered part in a circuit in the conversion process, and plays roles of input, output and isolation, so that the interference between the signals can be avoided, and the isolation can guarantee the safety of equipment and operators.
The pulse generating circuit 10 of the embodiment of the application adopts a topological structure of an RS485 master-slave network, and the master control board 1 is connected with other slave function boards (the pulse generating unit 4, the switching unit 5 and the emergency stop unit 7) through an RS485 serial bus. And each slave function board is provided with a processor independently and can work independently, and the master control board 1 can control each slave function board to work cooperatively through an RS485 network. Compared with the prior art in which the main control board concurrently controls other functional boards through the IO port, the connection interfaces are reduced, the wiring is simple, and the connection structure between the boards is greatly simplified. And the RS485 interface transmits signals in a differential mode, so that the anti-interference capability is improved and the response speed can be effectively improved compared with the concurrent control of an IO port in the prior art. In addition, when a new slave function board needs to be added, the slave function board is directly connected to the RS485 bus in series, and the method is simple and convenient. When the fault is maintained, only the functional board with the fault can be maintained, and the system maintenance is facilitated.
Fig. 7 is a schematic structural diagram of a tumor treatment device according to an embodiment. The tumor treatment device comprises: at least 2 electrode needles 20, an upper computer 30 and the pulse generating circuit 10. Wherein, host computer 30 passes through serial ports connection main control panel 1, for example, can select RS485 serial ports connection control panel 1, and switching unit 5's in the pulse generating circuit 10 output is connected to electrode needle 20.
The electrode needle 20 is specifically connected to the output of each switching channel in the switching unit 5. Optionally, the number of the electrode needles 20 is 8, the number of the switching channels in the switching unit 5 is also 8, and each electrode needle 20 is connected to one switching channel.
The electrode needles 20 are applied to a tumor tissue of a human body, so that a high voltage electric field is formed between the electrode needles 20 on the tumor tissue, and the high voltage electric field causes irreversible damage to tumor cells, so that the tumor cells are naturally apoptotic, and thus, the purpose of tumor treatment is achieved. The 8 electrode needles can be suitable for more tumor types, shapes, sizes and the like, so that more treatment modes are provided, and the product competitiveness is improved.
In the embodiment of the present application, the upper computer 30 may be a computing device such as a computer and a tablet computer. In some examples, the upper computer 30 may include various input/output devices. For example, the input device may be a touch screen, a keypad, or a full keyboard, among others. The output devices may be various visual, audible, tactile output devices, such as a display, LED lights, vibrators, and the like. The upper computer 30 is used for receiving treatment parameters (such as basic information and ablation parameters of a patient), transmitting control parameters, acquiring state information, monitoring a treatment process, displaying a treatment result, outputting a treatment report and the like.
The above description is only exemplary of the present application and should not be taken as limiting the present application, as any modification, equivalent replacement, or improvement made within the spirit and principle of the present application should be included in the scope of protection of the present application.

Claims (10)

1. A pulse generating circuit for use in a tumor treatment device including an electrode needle, the pulse generating circuit comprising: the device comprises a main control panel, an RS485 interface chip, a power supply unit, a pulse generation unit and a switching unit;
the pulse generating unit is configured with a first processor, and the switching unit is configured with a second processor;
the first UART port of the main control panel is connected with the input end of the RS485 interface chip, and the output end of the RS485 interface chip is respectively connected with the first processor and the second processor through an RS485 bus;
the second UART port of the main control board is connected with the input end of the power supply unit and is used for controlling the power supply unit to generate high-voltage direct-current voltage and outputting the high-voltage direct-current voltage to the pulse generating unit;
the input end of the pulse generating unit is connected with the output end of the power supply unit, and the pulse generating unit is responsive to the first processor and is used for receiving the high-voltage direct current voltage, converting the high-voltage direct current voltage into a bipolar pulse voltage and outputting the bipolar pulse voltage to the switching unit;
the input end of the switching unit is connected with the output end of the pulse generating unit, and the switching unit is responsive to the second processor and is used for receiving the bipolar pulse voltage and outputting the bipolar pulse voltage to the corresponding electrode needle.
2. The pulse generating circuit of claim 1, further comprising: an emergency stop unit;
the emergency stop unit comprises a third processor and an emergency stop switch;
the output end of the RS485 interface chip is connected with the third processor through the RS485 bus;
the emergency stop unit is connected between the power supply unit and the pulse generation unit;
the emergency stop unit is responsive to the third processor to cut off an energy input receiving the high voltage dc voltage from the power supply unit and cut off an energy output outputting the high voltage dc voltage to the pulse generation unit and release energy when the emergency stop switch is turned on.
3. The pulse generating circuit of claim 1, further comprising: a first isolation unit;
the first isolation unit is connected between the first UART port and the input end of the RS485 interface chip.
4. The pulse generating circuit of claim 1, further comprising: a second isolation unit;
the second isolation unit is connected between the second UART port and the input end of the power supply unit.
5. The pulse generating circuit of claim 1, wherein the switching unit comprises at least 2 switching channels, each switching channel comprising one single-pole double-throw switch and one single-pole single-throw switch;
two fixed ends of the single-pole double-throw switch are respectively connected with a positive polarity pulse voltage end and a negative polarity pulse voltage end of the bipolar pulse voltage;
the common end of the single-pole double-throw switch is connected to the electrode needle through the single-pole single-throw switch;
the enabling ends of the single-pole double-throw switch and the single-pole single-throw switch are respectively connected with the second processor.
6. The pulse generating circuit of claim 5, wherein there are 8 switching channels.
7. The pulse generating circuit of claim 1, wherein the main control board is built from an STM32F2 chip.
8. The pulse generation circuit of claim 2, wherein the first processor, the second processor, and the third processor are ARM Cortex-M3 processors.
9. The pulse generating circuit as claimed in claim 1, wherein the RS485 interface chip is SN65LBC176A series chip.
10. A tumor treatment apparatus, comprising: at least 2 electrode needles, an upper computer and a pulse generating circuit according to any one of claims 1 to 9;
the upper computer is connected with the main control board through a serial port;
the electrode needle is connected with the output end of the switching unit.
CN201921871707.4U 2019-11-01 2019-11-01 Pulse generating circuit and tumor treatment device Active CN211357441U (en)

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN113262040A (en) * 2021-05-19 2021-08-17 北京金石翔宇科技有限公司 Tumor ablation equipment using ultrahigh-voltage positive-negative composite pulse electric field

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN113262040A (en) * 2021-05-19 2021-08-17 北京金石翔宇科技有限公司 Tumor ablation equipment using ultrahigh-voltage positive-negative composite pulse electric field

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Address after: 200135 3rd floor, 2123 Pudong Avenue, China (Shanghai) pilot Free Trade Zone, Pudong New Area, Shanghai

Patentee after: Shanghai RuiDao Medical Technology Co.,Ltd.

Address before: 200135 3rd floor, 2123 Pudong Avenue, China (Shanghai) pilot Free Trade Zone, Pudong New Area, Shanghai

Patentee before: SHANGHAI REMEDICINE Co.,Ltd.