CN211255892U - Waste liquid recovery system for synthesizer and synthesizer - Google Patents
Waste liquid recovery system for synthesizer and synthesizer Download PDFInfo
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- CN211255892U CN211255892U CN201922101223.8U CN201922101223U CN211255892U CN 211255892 U CN211255892 U CN 211255892U CN 201922101223 U CN201922101223 U CN 201922101223U CN 211255892 U CN211255892 U CN 211255892U
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Abstract
The utility model relates to a waste liquid recovery field especially indicates a waste liquid recovery system and synthesizer for synthesizer. A waste liquid recovery system for a synthesizer includes: the liquid inlet pipe, the recovery switching device, the liquid outlet pipe, the recovery barrel and the negative pressure device; the recovery switching device comprises a plurality of channels, and each channel is provided with a corresponding control valve; the inlet end of each channel is communicated with a synthesis column of a synthesizer through a liquid inlet pipe, and the outlet end of each channel is communicated with a recovery barrel through a liquid outlet pipe; the negative pressure device is communicated with the recycling bin and enables negative pressure to be generated in the recycling bin. Through retrieving switching device's setting, can make every synthetic post all communicate with a recycling bin that corresponds, from this, can realize retrieving the waste liquid of synthetic post to the recycling bin that corresponds in, from this, can realize retrieving the mutual isolation of waste liquid, help the recycle of waste liquid.
Description
Technical Field
The utility model relates to a waste liquid recovery field especially indicates a waste liquid recovery system and synthesizer for synthesizer.
Background
The artificial synthesis of DNA is the only way for the directional modification of gene sequences known at present, and is widely applied to the fields of protein modification, life science and the like, such as nucleic acid medicine, enzyme engineering, gene therapy and the like. The DNA synthesizer needs different steps such as deprotection, activated linking, capping, oxidation and the like in the synthesis process, different reagents need to be injected into the synthesis column in the synthesis process under the protection of inert gas, and the reagents in the synthesis column are emptied after the reaction is finished. The discharged waste liquid is conveyed to a waste liquid tank by a pipeline, so that the residue of the waste liquid in the equipment is reduced to the maximum extent, and the waste liquid is very important for bearing the synthesis plate and influences the whole process of DNA synthesis.
But current waste liquid recovery system is unified to be retrieved to a waste liquid bucket, the recycle of inconvenient later stage waste liquid.
SUMMERY OF THE UTILITY MODEL
The utility model provides a waste liquid recovery system for synthesizer has solved the problem among the prior art.
The technical scheme of the utility model is realized like this:
a waste liquid recovery system for a synthesizer, comprising: the liquid inlet pipe, the recovery switching device, the liquid outlet pipe, the recovery barrel and the negative pressure device;
the recovery switching device comprises a plurality of channels, and each channel is provided with a corresponding control valve;
the inlet end of each channel is communicated with a synthesis column of a synthesizer through a liquid inlet pipe, and the outlet end of each channel is communicated with a recovery barrel through a liquid outlet pipe;
the negative pressure device is communicated with the recycling bin and enables negative pressure to be generated in the recycling bin.
Preferably, the recovery switching device comprises a first electromagnetic valve group and a second electromagnetic valve group;
the first electromagnetic valve group comprises a first valve body, a plurality of first inlet ends and a first outlet end, wherein the first inlet ends and the first outlet ends are arranged on the first valve body;
the second solenoid valve group comprises a second valve body, a plurality of second outlet ends and a second inlet end, wherein the second outlet ends and the second inlet end are arranged on the second valve body;
each first inlet end is communicated with one synthesis column through a liquid inlet pipe, the first outlet end is communicated with the second inlet end, and each second outlet end is communicated with one recovery barrel through a liquid outlet pipe;
the first inlet end and the second outlet end are arranged in pairs, and each pair of the first inlet end and the second outlet end is matched with the first outlet end and the second inlet end to form a channel.
Preferably, the first inlet end and the second outlet end are both provided with electromagnetic switches.
Preferably, one end of the liquid inlet pipe is hermetically connected with the first inlet end, and the other end of the liquid inlet pipe is hermetically connected with the synthetic column.
Preferably, one end of the liquid outlet pipe is connected with the second outlet end in a sealing mode, and the other end of the liquid outlet pipe is connected with the recycling bin in a sealing mode.
Preferably, the negative pressure device is a vacuum pump;
each recycling bin is communicated with the vacuum pump through a vacuum tube.
Preferably, a switch is arranged on the vacuum tube.
A synthesizer comprising a waste recovery system of a synthesizer as described above.
Preferably, the synthesizer comprises a synthesis column bracket and a synthesis column;
the synthetic column bracket comprises a slot, and the synthetic column is inserted in the slot.
The utility model discloses technical scheme can make every synthetic post all communicate with a recycling bin that corresponds through retrieving switching device's setting, from this, can realize retrieving the waste liquid of synthetic post to the recycling bin that corresponds in, from this, can realize retrieving the mutual isolation of waste liquid, helps the recycle of waste liquid.
Drawings
In order to more clearly illustrate the embodiments of the present invention or the technical solutions in the prior art, the drawings used in the description of the embodiments or the prior art will be briefly described below, it is obvious that the drawings in the following description are only some embodiments of the present invention, and for those skilled in the art, other drawings can be obtained according to these drawings without creative efforts.
Fig. 1 is a schematic diagram of the composition of the waste liquid recovery system for the synthesizer of the present invention.
1: synthesizing a column; 2: a recovery switching device; 3: a recycling bin; 4: a negative pressure device;
21: a first solenoid valve group; 22: a second solenoid valve block.
Detailed Description
The technical solutions in the embodiments of the present invention will be described clearly and completely with reference to the accompanying drawings in the embodiments of the present invention, and it is obvious that the described embodiments are only some embodiments of the present invention, not all embodiments. Based on the embodiments in the present invention, all other embodiments obtained by a person skilled in the art without creative efforts belong to the protection scope of the present invention.
As shown in fig. 1, in the present embodiment, there is provided a waste liquid recovery system for a synthesizer, which is suitable for recovering waste liquid in a synthesis column 1. It includes: feed liquor pipe, retrieve auto-change over device 2, drain pipe, recycling bin 3 and negative pressure device 4.
The recovery switching device 2 comprises a plurality of channels, and each channel is provided with a corresponding control valve.
The inlet end of each channel is communicated with a synthesis column 1 of a synthesizer through a liquid inlet pipe, and the outlet end of each channel is communicated with a recycling bin 3 through a liquid outlet pipe.
The negative pressure device 4 is communicated with the recycling bin 3 and generates negative pressure in the recycling bin 3.
In this embodiment, by setting the recovery switching device 2, each synthesis column 1 can be communicated with one corresponding recovery tank 3, and thus, the waste liquid of the synthesis column 1 can be recovered into the corresponding recovery tank 3, and therefore, the mutual isolation of the recovered waste liquid can be realized, and the recovery and utilization of the waste liquid are facilitated.
The recovery switching device 2 includes a first solenoid valve group 21 and a second solenoid valve group 22.
The first solenoid valve 21 group includes a first valve body, and a plurality of first inlet ports and a first outlet port provided on the first valve body, and when the first solenoid valve group 21 is opened, the first outlet port can communicate with only one of the first inlet ports.
The second solenoid valve group 22 includes a second valve body, and a plurality of second outlet ports and a second inlet port provided on the second valve body, and the second inlet port can communicate with only one of the second outlet ports when the second solenoid valve group 22 is opened.
Wherein, every first entrance point all communicates with a synthetic column 1 through a feed liquor pipe, and first exit end and second entrance point intercommunication, every second exit end all communicates with a recycling bin 3 through a drain pipe.
It should be noted that: the first inlet ports of the first solenoid valve group 21 share the same first outlet port, and the second outlet ports of the second solenoid valve group 22 share the same first inlet port.
The first inlet end and the second outlet end are arranged in pairs, and each pair of the first inlet end and the second outlet end is matched with the first outlet end and the second inlet end to form a channel.
That is, when the first solenoid valve set 21 and the second solenoid valve set 21 are both opened, a channel is formed between the first solenoid valve set 21 and the second solenoid valve set 21, a flow path of liquid in the channel is that the liquid enters the first solenoid valve set 21 through a first inlet end, flows out of the first solenoid valve set 21 through a first outlet end, enters the second solenoid valve set 22 through a second inlet end, and finally flows into the second solenoid valve set 22 through a second outlet end.
The control valves arranged on the channels are electromagnetic switches, and specifically, the first inlet end and the second outlet end are both provided with electromagnetic switches.
In another embodiment, the control valve disposed on the channel is a valve core, specifically, the valve cores are disposed on both the first valve body and the second valve body, one of the first inlet ports can be communicated with the first outlet port by changing the position of the valve core on the first solenoid valve group 21, and the second inlet port can be communicated with one of the second outlet ports by changing the position of the valve core on the second solenoid valve group 22.
One end of the liquid inlet pipe is hermetically connected with the first inlet end, and the other end of the liquid inlet pipe is hermetically connected with the synthetic column 1. In addition, the first outlet end and the second inlet end are also hermetically connected through a pipeline.
One end of the liquid outlet pipe is hermetically connected with the second outlet end, and the other end of the liquid outlet pipe is hermetically connected with the recycling bin 3.
Through this kind of setting, can make and form sealed space between synthetic post 1, first electromagnetism valves 21, second electromagnetism valves 22 and the recycling bin 3, under negative pressure device 4's effect, can make and produce the negative pressure in this space, and then retrieve the waste liquid in the synthetic post 1 to the recycling bin 3 in.
In addition, the negative pressure device 4 provides a pressure ranging from-2 psi to-8 psi, under the action of the pressure, the liquid in the synthetic column 1 is almost completely recovered into the recovery barrel 3, and the synthetic column can be used next time.
The negative pressure device 4 is a vacuum pump, and each recycling bin 3 is communicated with the vacuum pump through a vacuum tube. The vacuum tube is provided with a switch.
Through set up the switch on the vacuum tube, when certain or some recycling bin need retrieve the waste liquid, as long as open corresponding switch, produce the negative pressure in the recycling bin 3 that makes the waste liquid of needs retrieve can. Therefore, the energy can be saved.
To further explain the above waste liquid recovery system, the present embodiment also provides a specific embodiment of the waste liquid recovery system:
the waste liquid recovery device comprises a vacuum pump, a recovery barrel 3, a first electromagnetic valve group 21 and a second electromagnetic valve group 22;
specifically, the device comprises four independently arranged recycling barrels 3, wherein the four recycling barrels 3 are respectively an A recycling barrel, a G recycling barrel, a C recycling barrel and a T recycling barrel;
the first solenoid valve group 21 includes a first inlet port a, a first inlet port G, a first inlet port C, a first inlet port T, and a first outlet port;
the second solenoid valve group 22 includes a second inlet port, a second outlet port a, a second outlet port G, a second outlet port C, and a second outlet port T;
the device correspondingly comprises four synthetic columns 1, wherein the four synthetic columns are respectively an A synthetic column, a G synthetic column, a C synthetic column and a T synthetic column.
The A synthetic column is communicated with the A first inlet end, the G synthetic column is communicated with the G first inlet end, the C synthetic column is communicated with the C first inlet end, and the T synthetic column is communicated with the T first inlet end;
the first outlet end is communicated with the second inlet end;
the A second outlet end is communicated with the A recycling bin, the G second outlet end is communicated with the G recycling bin, the C second outlet end is communicated with the C recycling bin, and the T second outlet end is communicated with the T recycling bin.
A recycling bin, G recycling bin, C recycling bin and T recycling bin 3 all communicate with the vacuum pump.
In the waste liquid discharging process, the vacuum pump works, the pressure of the recovery barrel 3 is reduced to be within the trial requirement range (-2 to-8 psi), and the waste liquid is recovered by switching the corresponding electromagnetic valves to be opened and closed.
If the monomer A is in reaction, the communication among the first inlet end A, the second outlet end A and the recycling barrel A is mainly controlled, so that the waste liquid of the monomer A is collected and switched, and the waste liquid of the monomer A is collected in the recycling barrel A.
If the G monomer is mainly through controlling the intercommunication between the first entrance point of G, the second exit end of G and the G recycling bin when reacting, realize the switching that G monomer waste liquid was collected, collect the G recycling bin with the waste liquid of G monomer reaction.
The monomer C mainly realizes the switching of collecting the monomer C waste liquid by controlling the communication among the first inlet end of the monomer C, the second outlet end of the monomer C and the recovery barrel of the monomer C during the reaction, and the waste liquid generated by the monomer C reaction is collected into the recovery barrel of the monomer C.
T monomer is mainly through controlling the intercommunication between the first entrance point of T, the second exit end of T and the T recycling bin when the reaction, realizes the switching that T monomer waste liquid was collected, collects T recycling bin with T monomer reaction's waste liquid.
In this embodiment, there is also provided a synthesizer comprising a waste liquor recovery system of the synthesizer as described above.
The synthesizer comprises a synthetic column bracket and a synthetic column 1, wherein the synthetic column bracket comprises a slot, and the synthetic column is inserted in the slot.
The synthetic column is arranged in the slot, so that the stability of installation of the synthetic column 1 can be improved.
The above description is only a preferred embodiment of the present invention, and should not be taken as limiting the invention, and any modifications, equivalent replacements, improvements, etc. made within the spirit and principle of the present invention should be included in the protection scope of the present invention.
Claims (9)
1. A waste liquid recovery system for a synthesizer, comprising: the liquid inlet pipe, the recovery switching device, the liquid outlet pipe, the recovery barrel and the negative pressure device;
the recovery switching device comprises a plurality of channels, and each channel is provided with a corresponding control valve;
the inlet end of each channel is communicated with a synthesis column of a synthesizer through a liquid inlet pipe, and the outlet end of each channel is communicated with a recovery barrel through a liquid outlet pipe;
the negative pressure device is communicated with the recycling bin and enables negative pressure to be generated in the recycling bin.
2. The waste liquid recovery system for a synthesizer according to claim 1, wherein the recovery switching means comprises a first solenoid valve block and a second solenoid valve block;
the first electromagnetic valve group comprises a first valve body, a plurality of first inlet ends and a first outlet end, wherein the first inlet ends and the first outlet ends are arranged on the first valve body;
the second solenoid valve group comprises a second valve body, a plurality of second outlet ends and a second inlet end, wherein the second outlet ends and the second inlet end are arranged on the second valve body;
each first inlet end is communicated with one synthesis column through a liquid inlet pipe, the first outlet end is communicated with the second inlet end, and each second outlet end is communicated with one recovery barrel through a liquid outlet pipe;
the first inlet end and the second outlet end are arranged in pairs, and each pair of the first inlet end and the second outlet end is matched with the first outlet end and the second inlet end to form a channel.
3. The waste liquid recovery system for synthesizer according to claim 2, wherein the first inlet end and the second outlet end are each provided with an electromagnetic switch.
4. The waste liquid recovery system for synthesizer according to claim 2, wherein one end of the liquid inlet pipe is hermetically connected to the first inlet end, and the other end of the liquid inlet pipe is hermetically connected to the synthesizing column.
5. The waste liquid recovery system for synthesizer as claimed in claim 2, wherein one end of the liquid outlet pipe is connected with the second outlet end in a sealing manner, and the other end of the liquid outlet pipe is connected with the recovery barrel in a sealing manner.
6. The waste liquid recovery system for a synthesizer according to claim 1, wherein the negative pressure means is a vacuum pump;
each recycling bin is communicated with the vacuum pump through a vacuum tube.
7. The waste liquid recovery system for synthesizer according to claim 6, wherein a switch is provided on the vacuum tube.
8. A synthesizer characterized by comprising a waste liquid recovery system of the synthesizer according to any one of claims 1 to 7.
9. The synthesizer of claim 8, wherein the synthesizer includes a synthesis column holder and a synthesis column;
the synthetic column bracket comprises a slot, and the synthetic column is inserted in the slot.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201922101223.8U CN211255892U (en) | 2019-11-28 | 2019-11-28 | Waste liquid recovery system for synthesizer and synthesizer |
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| Application Number | Priority Date | Filing Date | Title |
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| CN201922101223.8U CN211255892U (en) | 2019-11-28 | 2019-11-28 | Waste liquid recovery system for synthesizer and synthesizer |
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| CN211255892U true CN211255892U (en) | 2020-08-14 |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN114573653A (en) * | 2022-01-26 | 2022-06-03 | 北京擎科生物科技有限公司 | Gas-liquid path system for automatic synthesis of nucleic acid and synthesis system |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN114573653A (en) * | 2022-01-26 | 2022-06-03 | 北京擎科生物科技有限公司 | Gas-liquid path system for automatic synthesis of nucleic acid and synthesis system |
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