CN211246449U - Dry granulation device for crystallized mannitol - Google Patents
Dry granulation device for crystallized mannitol Download PDFInfo
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- CN211246449U CN211246449U CN201922115654.XU CN201922115654U CN211246449U CN 211246449 U CN211246449 U CN 211246449U CN 201922115654 U CN201922115654 U CN 201922115654U CN 211246449 U CN211246449 U CN 211246449U
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Abstract
The utility model relates to a crystallization mannitol dry granulation device, including feed bin, tablet press, rubbing crusher, first separator, screening machine and finished product storehouse, be provided with the conveyer that has continuous pay-off ability between feed bin and the tablet press, the crystallization mannitol material of treating the granulation in the feed bin enters the rubbing crusher after the tablet press preforming and smashes, and the mannitol crystal crushed aggregates after smashing gets into behind the screening machine screening after the separation of first separator and gets into the finished product storehouse and keep in. The utility model discloses a crystalline mannitol material of treating the granulation carries out preforming, smashes, sieves and makes mannitol crystal granule finished product, has improved production efficiency, has the advantage that the energy consumption is low.
Description
Technical Field
The utility model belongs to the technical field of the crystal granulation, in particular to crystallization mannitol dry process prilling granulator.
Background
Mannitol (D-mannitol) is colorless acicular or rhombic column crystals or white crystalline powder, has high solubility and melting point, has the sweetness of 50 percent of that of cane sugar, does not absorb moisture, has good thermal stability, is stable to dilute acid and dilute alkali, and has the chemical characteristics of polyhydric alcohol. The traditional industrial production method mainly comprises a kelp extraction and sucrose hydrolysis catalysis method, and mannitol particles obtained after refining and crystallization are fine, crisp and poor in fluidity, so that the further popularization and application of the mannitol particles in the industries of medicine, food, chemical industry and the like are limited.
At present, the method for improving the fluidity of the crystallized mannitol mainly adopts granulation, and a U.S. patent with publication number of US5160680A discloses a melt extrusion granulation method, wherein a 166 ℃ mannitol non-full molten liquid is extruded into a rod shape, and then is crushed and sieved, and the method needs to consume more heat for heating, and has high equipment requirement and high energy consumption. In addition, there are methods such as boiling granulation, mixing granulation, and spray granulation, in which mannitol or steam with a certain concentration is used as a binder, which results in high heat energy consumption, and if other substances are used as a binder, the mannitol purity is affected, and the material needs to be further dried after granulation, and if the temperature drops suddenly after granulation, the obtained powder product may be in a vitreous form and unstable in properties. The granulation method is a method commonly used in the food industry, and granulation is carried out by using a dry method in other industries. For example, chinese patent application publication No. CN103754872A discloses a dry granulation process for calcium carbide powder, which collects dust generated during the pulverization of calcium carbide, and performs extrusion, rolling, and granulation to obtain a granular material, and the method has the following disadvantages: (1) the materials are compressed in a ballast way, so that the pressure resistance requirement of the equipment is high; (2) the continuous property is influenced by normal pressure conveying and pressurization compression.
SUMMERY OF THE UTILITY MODEL
The utility model aims to solve the technical problem that a crystallization mannitol dry granulation device is provided, directly carry out preforming, crushing, screening to crystallization mannitol, obtain granular mannitol, whole process is continuous, high-efficient, low energy consumption, does not need melting or secondary drying, prepares the granular mannitol that the mobility is good, the friability is low.
The utility model discloses a realize like this, provide a crystallization mannitol dry process prilling granulator, including feed bin, tablet press, rubbing crusher, first separator, screening machine and finished product storehouse, be provided with the conveyer that has continuous feeding capacity between feed bin and the tablet press, treat the crystallization mannitol material storage of granulation in the feed bin, the tablet press is treated the crystallization mannitol material of granulation and is carried out the preforming, obtains slice crystallization mannitol, the rubbing crusher smashes slice crystallization mannitol, obtains mannitol crystal crushed aggregates, the screening machine sieves mannitol crystal crushed aggregates after first separator separation, the mannitol crystal granule that obtains after the screening machine screening gets into the finished product storehouse and keeps in.
In this scheme, the crystallized mannitol material of treating the granulation in the feed bin enters rubbing crusher and smashes after the tablet press preforming, the mannitol crystal crushed aggregates after the rubbing crusher crushing gets into the screening machine screening after first separator separation, wherein, the mannitol crystal granule after the screening machine screening gets into the finished product storehouse, be provided with the conveyer that has continuous feeding ability between feed bin and tablet press, the conveyer carries the crystallized mannitol material of treating the granulation in the feed bin to the tablet press. Compared with the prior art, the scheme has the advantages that the mannitol crystal particles are prepared by tabletting, crushing and screening the crystallized mannitol material to be granulated, and the crystallized mannitol does not need to be melted or dried for the second time in the whole manufacturing process, so that the manufacturing efficiency of the mannitol crystal particles is improved, and the mannitol crystal particles have the advantage of low energy consumption. In addition, this scheme adopts the conveyer that has continuous feeding ability to carry the material in the feed bin to the tablet press, has the advantage that the continuity is good among the granulation process.
Further, still set up second separator and first rotary valve on the feed bin respectively, the crystallization mannitol material of treating the granulation is carried behind the first rotary valve and is got into the second separator, by get into the feed bin after the second separator separates.
Furthermore, the screening machine is provided with a single-layer screen, undersize materials enter the first finished product bin for temporary storage, oversize materials are conveyed back to the grinding machine for grinding and recycling, and mannitol crystal particles temporarily stored in the first finished product bin enter the next procedure after passing through a second rotary valve arranged at the bottom of the first finished product bin.
Furthermore, the screening machine is provided with double layers of screens, large-particle oversize products on the screen on the upper layer are conveyed back to the crusher to be crushed again for utilization, undersize products on the screen on the lower layer enter a first finished product bin for temporary storage, and oversize products enter a second finished product bin for temporary storage; and the mannitol crystal particles temporarily stored in the first finished product bin enter the next procedure through a second rotary valve arranged at the bottom of the first finished product bin, and the mannitol crystal particles temporarily stored in the second finished product bin enter the next procedure through a third rotary valve arranged at the bottom of the second finished product bin.
Furthermore, a return pipeline is arranged beside the second rotary valve, and mannitol crystal particles temporarily stored in the first finished product bin are conveyed to a second separator through the return pipeline for retreatment.
Furthermore, the screen mesh number of the screening machine is 20-60 meshes.
Compared with the prior art, the utility model discloses a crystallized mannitol dry granulation device and technology, the crystallized mannitol material of treating the granulation in the feed bin enters the rubbing crusher after the tablet press preforming and smashes, the mannitol crystal crushed aggregates after the rubbing crusher is smashed gets into the screening machine screening after first separator separation, the mannitol crystal granule after the screening gets into the finished product storehouse, be provided with the conveyer that has continuous pay-off ability between feed bin and tablet press, the conveyer carries the crystallized mannitol of treating the granulation in with the feed bin to the tablet press. The utility model discloses still have following characteristics:
1) the needle-shaped or rod-shaped structure of the crystallized mannitol is destroyed in the tabletting and crushing processes, and then is subjected to pipeline conveying and friction, so that the product is macroscopically round, the flowability of the product is favorably improved, and the flowability of the finished product is less than 7s/100 g.
2) The crystallized mannitol material to be granulated is directly tabletted, and the crystallized mannitol is not required to be dissolved or melted in the production process, so that the energy consumption is reduced.
3) And no adhesive is adopted in the granulation process, so that the purity of the granulated mannitol crystal particles is not influenced.
4) And secondary drying is not needed in the granulation process, so that the production cost is reduced, and the moisture of the finished product is less than 0.15%.
5) And continuous operation can be realized under the condition of sufficient raw materials in the granulation production process.
6) The friability of the granulated mannitol crystal granule finished product is as low as 10-45%, and fine powder is not easy to generate in the transportation and use processes of the finished product.
Drawings
Fig. 1 is a schematic structural principle diagram of a preferred embodiment of the dry granulation apparatus for crystallized mannitol of the present invention.
Detailed Description
In order to make the technical problem, technical solution and advantageous effects to be solved by the present invention more clearly understood, the following description is given in conjunction with the accompanying drawings and embodiments to illustrate the present invention in further detail. It should be understood that the specific embodiments described herein are merely illustrative of the invention and are not intended to limit the invention.
Referring to fig. 1, the preferred embodiment of a dry granulation apparatus for crystallized mannitol of the present invention comprises a storage bin 1, a tablet press 2, a pulverizer 3, a first separator 4, a sieving machine 5 and a finished product bin. A conveyor 6 with continuous feeding capacity is arranged between the bin 1 and the tablet press 2.
The mass of crystallized mannitol to be granulated is stored in the silo 1. And the tablet press 2 is used for pressing the crystalline mannitol material to be granulated to obtain the flaky crystalline mannitol. And the pulverizer 3 pulverizes the flaky crystalline mannitol to obtain mannitol crystal crushed aggregates. The screening machine 5 screens the mannitol crystal crushed aggregates separated by the first separator 4, and mannitol crystal particles obtained after screening by the screening machine 5 enter a finished product bin for temporary storage.
In the preferred embodiment, the storage bin 1 is used for storing raw materials, the raw materials in the storage bin 1 are continuously fed to the tablet press 2 through the conveyor 6, the tablet press 2 performs tabletting on the raw materials conveyed by the conveyor 6, then the raw materials tabletted by the tablet press 2 are crushed by the crusher 3, separated by the first separator 4, screened by the screening machine 5, and screened by the screening machine 5 to enter the finished product storage bin. Compared with the prior art, the scheme has simple process, and the finished product is prepared by directly tabletting the raw materials, then crushing and screening the crushed materials by a screening machine 5. The scheme improves the production efficiency of the crystal mannitol, reduces energy consumption, and has good continuity in the whole production process.
A second separator 9 and a first rotary valve 10 are also arranged on the silo 1, respectively. The crystallized mannitol material to be granulated is conveyed into the second separator 9 after passing through the first rotary valve 10, and is separated by the second separator 9 and then enters the storage bin 1.
As an embodiment, the sieving machine 5 is provided with a single-layer screen, undersize materials enter the first finished product bin 7 for temporary storage, oversize materials are conveyed back to the crushing machine 3 for crushing and recycling, and mannitol crystal particles temporarily stored in the first finished product bin 7 enter a next packaging process after passing through a second rotary valve 11 arranged at the bottom of the first finished product bin 7.
As another example, the sieving machine 5 is provided with two layers of screens, the oversize material of large particles on the upper layer of screen is conveyed back to the crusher 3 to be crushed again, the undersize material on the lower layer of screen enters the first finished product bin 7 for temporary storage, and the oversize material on the lower layer of screen enters the second finished product bin 8 for temporary storage. And the mannitol crystal particles temporarily stored in the first finished product bin 7 enter the next packaging procedure after passing through a second rotary valve 11 arranged at the bottom of the first finished product bin 7. The mannitol crystal particles temporarily stored in the second finished product bin 8 enter the next packaging process through a third rotary valve 12 arranged at the bottom of the second finished product bin 8.
In some preferred embodiments, the first finished goods silo 7 and the second finished goods silo 8 have automatic weighing capability. The finished product bin has the automatic weighing capacity, namely, the finished product bin can automatically acquire the weight of the materials in the finished product bin, so that the accurate measurement of the weight of the materials in the finished product bin is facilitated, and the monitoring of the weight of the finished products in the finished product bin is facilitated. The first finished product bin 7 and the second finished product bin 8 are independent from each other, so that the first finished product bin 7 and the second finished product bin 8 can contain mannitol crystal particles with different particle size specifications.
A return line 13 is also arranged next to the second rotary valve 11, and mannitol crystal particles temporarily stored in the first finished product bin 7 are conveyed to the second separator 9 through the return line 13 for further treatment.
The screen mesh number of the screening machine 5 is 20-60 meshes. In some preferred embodiments, the conveyor 6 is a screw conveyor (commonly known as a screw auger). The packing auger has good continuous feeding capacity, and the continuous feeding capacity of the conveyor 6 is optimized. The conveyor 6 may be replaced by other structures having continuous feed capability.
In some preferred embodiments, the first finished product bin 7, the second finished product bin 8 and the second separator 9 are connected with independent dust collectors for removing fine mannitol crystal dust. The first separator 4 is connected with the draught fan, and is convenient for convey the mannitol crystal crushed aggregates after the crusher 3 crushes and separate.
Utility model the feeding amount of tablet press 2 is 0.5T/h ~ 1.5T/h, compression roller pressure control 2MPa ~ 6MPa, and the ejection of compact piece of preforming is thick 1.5mm ~ 3.5 mm.
In the process, air is used for conveying, the air temperature is 20-30 ℃, and the humidity is less than 45%. 16 grinding blocks of the crusher 3 have the working frequency of 15 Hz-35 Hz and the induced draft fan has the frequency of 75% -95%.
The following further describes the method of using the present invention in conjunction with specific embodiments.
Example 1
The utility model discloses a continuous prilling granulator's of crystallization mannitol dry process use method's first embodiment, it includes following step:
conveying the crystalline mannitol material to be granulated in the bin 1 to a tablet press 2 through a conveyor 6 for tabletting, then feeding the material into a crusher 3 for crushing, separating the crushed mannitol crystal material crushed by the crusher 3 through a first separator 4, then feeding the separated mannitol crystal material into a screening machine 5 for screening, and feeding the mannitol crystal particles obtained after screening by the screening machine 5 into a finished product bin for temporary storage.
Wherein, the grain diameter of the crystallized mannitol material to be granulated is less than 116um, 0.5T and the water content is 0.09%. The feeding amount of the tablet press 2 is controlled to be 0.5T/h, and the thickness of the discharged tablet is 2.0 mm. The working frequency of the pulverizer 3 is 20Hz, and the induced draft fan is 75 percent. The screening machine 5 adopts a single-layer screen, the aperture of the screen is 40 meshes, the undersize is a finished product of mannitol crystal particles, and the undersize is temporarily stored in the first finished product bin 7.
The finished mannitol crystal particles obtained in this example were subjected to characteristic evaluation, and evaluation items including particle size distribution, flowability, friability and moisture were examined to obtain the following evaluation results, respectively:
example 2
The utility model discloses a continuous prilling granulator's of crystallization mannitol dry process use method's second kind embodiment, the step of this embodiment is the same with embodiment 1, and only specific parameter is different.
Wherein, the grain diameter of the crystallized mannitol material to be granulated is less than 116um, 1T, and the water content is 0.08 percent. The feeding amount of the tablet press 2 is controlled to be 0.8T/h, and the thickness of the discharged tablet is 1.5 mm. The working frequency of the pulverizer 3 is 15Hz, and the induced draft fan is 75 percent. The screening machine 5 adopts double-layer screens, the screen mesh diameter of the upper layer is 40 meshes, the screen mesh diameter of the lower layer is 60 meshes, the undersize material of the lower layer screen returns to the material bin 1, and the oversize material enters the second finished product bin 8 for temporary storage.
The finished mannitol crystal particles obtained in this example were subjected to characteristic evaluation, and evaluation items including particle size distribution, flowability, friability and moisture were examined to obtain the following evaluation results, respectively:
example 3
The utility model discloses a third embodiment of the application method of the continuous prilling granulator of crystallization mannitol dry process, the step of this embodiment is the same with embodiment 1, and only specific parameter is different.
Wherein, the grain diameter of the crystallized mannitol material to be granulated is less than 116um, 2T, and the water content is 0.08 percent. The feeding amount of the tablet press 2 is controlled to be 1T/h, and the thickness of the discharged tablet is 3.5 mm. The working frequency of the pulverizer 3 is 35Hz, and the induced draft fan is 95 percent. The screening machine 5 adopts double-layer screens, the screen mesh diameter of the upper layer is 40 meshes, the screen mesh diameter of the lower layer is 60 meshes, undersize materials of the lower layer screen mesh enter the first finished product bin 7 for temporary storage, and oversize materials enter the second finished product bin 8 for temporary storage.
The two types of mannitol crystal granule finished products obtained in the example are subjected to characteristic evaluation, and evaluation items comprise particle size distribution, fluidity, friability and moisture, and the evaluation results are respectively obtained through detection according to the following table.
(A) The detection result of the mannitol crystal particle finished product entering the first finished product bin 7
(B) The detection result of the mannitol crystal particle finished product entering the second finished product bin 8
The evaluation items of the characteristics of the mannitol crystal particles in the above examples were respectively tested by the following methods:
(1) particle size distribution: the test sieve with the specified size is assembled from the chassis to the top in the order of increasing sieve pores, the test sieve is installed on a vibrating screen machine, 50.00g of sample is weighed and placed on the test sieve at the top, the test sieve is fixed by covering a top cover, the vibration time is set for 5min, the test sieve is started, the equipment stops weighing sieve residues, and the ratio of each interval is calculated.
(2) Fluidity: the powder fluidity tester is adopted for testing, 100g of sample is weighed and placed in a conical funnel, the diameter of the funnel opening is 15mm, the switch instrument is turned on to start timing, the sample freely falls, the valve is closed when the sample in the funnel completely falls, the instrument stops timing, and the indicated time is the fluidity value of the sample, and the unit is s/100 g.
(3) Friability: sieving the product with a 80-mesh sieve, weighing 20g, adding 25 glass beads with the diameter of 7-8 mm, putting the glass beads into a friability apparatus, rotating for 10min at the rotating speed of 25rpm, collecting the glass beads, sieving the glass beads with the 80-mesh sieve, weighing the weight of the particles on the sieve, and calculating the weight loss percentage of the particles.
(4) Moisture content: and (3) detecting by adopting a vacuum drying method at 60 ℃.
The above description is only exemplary of the present invention and should not be taken as limiting the scope of the present invention, as any modifications, equivalents, improvements and the like made within the spirit and principles of the present invention are intended to be included within the scope of the present invention.
Claims (6)
1. The utility model provides a continuous prilling granulator of crystalline mannitol dry process, its characterized in that, including feed bin (1), tablet press (2), rubbing crusher (3), first separator (4), screening machine (5) and finished product storehouse, be provided with conveyer (6) that have continuous feeding ability between feed bin (1) and tablet press (2), treat the crystalline mannitol material of granulation and store in feed bin (1), tablet press (2) are treated the crystalline mannitol material of granulation and are carried out the preforming, obtain slice crystalline mannitol, rubbing crusher (3) are smashed slice crystalline mannitol, obtain mannitol crystal crushed aggregates, screening machine (5) are sieved mannitol crystal crushed aggregates after first separator (4) separation, the mannitol crystal granule that obtains after screening machine (5) sieves gets into the finished product storehouse and keeps in temporarily.
2. The dry continuous granulator according to claim 1, characterized in that the silo (1) is further provided with a second separator (9) and a first rotary valve (10), respectively, and the crystallized mannitol material to be granulated is conveyed to the second separator (9) after passing through the first rotary valve (10), and is separated by the second separator (9) and then enters the silo (1).
3. The dry continuous crystallized mannitol granulation apparatus according to claim 2, wherein the sieving machine (5) is provided with a single-layer sieve, the undersize material enters the first finished product bin (7) for temporary storage, the oversize material is conveyed back to the pulverizer (3) for pulverization and reuse, and the mannitol crystal particles temporarily stored in the first finished product bin (7) enter the next process after passing through the second rotary valve (11) arranged at the bottom of the first finished product bin (7).
4. The dry continuous crystallized mannitol granulation device according to claim 2, wherein the sieving machine (5) is provided with double-layer sieves, the oversize product of the large granules on the upper layer of the sieve is conveyed back to the crushing machine (3) to be crushed again for use, the undersize product on the lower layer of the sieve is temporarily stored in the first finished product bin (7), and the oversize product is temporarily stored in the second finished product bin (8); mannitol crystal particles temporarily stored in the first finished product bin (7) enter the next working procedure through a second rotary valve (11) arranged at the bottom of the first finished product bin (7), and mannitol crystal particles temporarily stored in the second finished product bin (8) enter the next working procedure through a third rotary valve (12) arranged at the bottom of the second finished product bin (8).
5. The dry continuous granulator according to claim 3 or 4, wherein a return line (13) is further provided beside the second rotary valve (11), and mannitol crystal particles temporarily stored in the first product bin (7) are transferred to the second separator (9) through the return line (13) for further treatment.
6. The dry continuous granulator of crystallized mannitol according to claim 3 or 4, wherein the screen mesh number of the screening machine (5) is 20-60 mesh.
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN110787722A (en) * | 2019-12-01 | 2020-02-14 | 浙江华康药业股份有限公司 | Dry granulation device and process for crystallized mannitol |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110787722A (en) * | 2019-12-01 | 2020-02-14 | 浙江华康药业股份有限公司 | Dry granulation device and process for crystallized mannitol |
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