CN211214409U

CN211214409U - Procaterol hydrochloride solid preparation dosing device

Info

Publication number: CN211214409U
Application number: CN201921947116.0U
Authority: CN
Inventors: 杨晓晖; 左军; 杨贵滨; 张莉; 马晶; 马凌风
Original assignee: Heilongjiang Longde Pharmaceutical Co ltd
Current assignee: Heilongjiang Longde Pharmaceutical Co ltd
Priority date: 2019-11-12
Filing date: 2019-11-12
Publication date: 2020-08-11
Anticipated expiration: 2029-11-12

Abstract

The utility model discloses a procaterol hydrochloride solid preparation device of dosing is provided with first built-in groove and second built-in groove on the casing, and two built-in grooves are through built-in hole intercommunication, and sliding insertion has dampproofing procaterol hydrochloride powder medicament in the first built-in groove, and fixed embedding has the lantern ring on its inner wall, and it is provided with the push rod to slide in the lantern ring, and the push rod has the push pedal through first spring fixed connection with the casing, the other end fixed mounting of push rod. The procaterol hydrochloride solid preparation administration device drives the push plate to move through the push rod, can rapidly extrude medicament divided doses from moistureproof procaterol hydrochloride powder medicaments in batches, falls between the two crushing rollers through the built-in hole, then crushes the innermost layer of the medicament through the two crushing rollers for packaging, releases the medicament powder, and filters and isolates scraps through the filter screen, so that the scraps cannot be mistakenly sucked when the medicine is sucked; the device is suitable for oral administration of solid particles and micro powder of medicines such as procaterol hydrochloride and the like.

Description

Procaterol hydrochloride solid preparation dosing device

Technical Field

The utility model relates to a solid preparation device field of dosing specifically is a procaterol hydrochloride solid preparation device of dosing.

Background

Procaterol hydrochloride is a selective beta 2 receptor agonist, has selectivity for the beta 2 receptor of bronchus, has effects of dilating bronchus and resisting allergy, and can inhibit rapid airway resistance increase, and can be used for treating bronchial asthma, asthmatic bronchitis, emphysema, etc.

The procaterol hydrochloride has dosage forms of liquid preparation, solid preparation, aerosol, etc. Wherein the liquid preparation is inconvenient to carry in travel, is fragile and easy to leak, and the dosage division is inaccurate when the patient self-administers the medicine; the aerosol needs extra propellant, which easily causes ozone layer damage, and can not be used after leakage because of high pressure and containing inflammable substances which need special containers and transportation and storage conditions, and the sudden release of the pressure can cause mechanical damage and human body damage.

The solid preparation has accurate dosage division of particles and powder granules, is convenient for patients to self-administer, solves the problems of throat blockage and anhydrous medicine taking at present, and is suitable for the elderly with less saliva to take medicine. By oral inhalation in the form of solid preparations, the medicament can be deposited in the oral cavity or the air passage for treating pulmonary diseases. However, the conventional solid oral inhalation administration device can only put one unit of solid preparation such as one capsule each time, and needs repeated operations of encapsulating, crushing, sucking and cleaning, which is very complicated. And the preparation package is broken and thrown away to pollute the environment. This cumbersome operation results in reduced patient compliance during travel, and contamination of the environment with packaging increases the workload on sanitation personnel. Devices that can be flipped into multiple medicament units are complex and have a number of drawbacks. The device of CN201320575009.6, which uses a bottle and a metering knob for repeated use and dose division, requires gravity and shaking to release the powder from the bottle for inhalation, but the bottle is heavy and must be placed with its opening downward, which cannot be closed or the powder cannot be released, which results in the drug being easily affected by moisture. The CN201580011817.1 device adopts piercing structure and bubble cap structure, but the powder medicine in the bubble cap needs each bubble cap dent to correspond to a collection dent, and each collection dent corresponds to an air flow channel, otherwise the collection dent air flow conditions at different positions are different, and the suction effect is also different. The blister depression and the collection depression are concave toward the side wall, resulting in insufficient release of the active ingredient, whether punctured or cut into the contents. The device is placed upright after puncturing, and then the powder which is not inhaled is discharged from the suction nozzle, and the bottom powder storage structure is lacked. And the elasticity construction for puncturing adopts a curvature structure, the elasticity is unstable, each device only has one curvature structure, otherwise, the puncturing devices are linked, other structures which are not punctured are accidentally punctured, and the blister has to be repeatedly pulled and pulled.

Accordingly, there is a need for an oral administration device capable of containing multiple solid dosage units and multiple doses of solid dosage forms at one time, capable of semi-automatic, fractional delivery and comminuted release of drug particles or powder particles at the time of use, while permitting separation of the comminuted packages and storage of a number of broken packages for centralized disposal. The pre-filled medicine is prevented from being affected with damp, and the required amount of solid preparations can be crushed only by simple operation when acute symptoms appear, so that the operation steps are saved; and can store a plurality of damaged capsule shells so as to be intensively put into a garbage station to avoid polluting the environment.

Disclosure of Invention

To above realistic problem, the utility model aims to provide a procaterol hydrochloride solid preparation device of dosing to solve the multi-dose and administer, medicament content and the dampproofing, damaged medicine package material storage scheduling problem of inner packing, reduce the user and get and put operating frequency, make things convenient for the travel to use medicine etc..

In order to achieve the above object, the utility model provides a following technical scheme:

the whole procaterol hydrochloride solid preparation administration device is a hollow shell, the height of the shell can be 1.2-1.6 times of that of an aluminum-plastic blister capsule plate, the width of the shell is 0.6-1.2 times of that of the aluminum-plastic blister capsule plate, and the thickness of the shell is 2-3 times of that of the aluminum-plastic blister capsule plate; such dimensions are only from the point of view of functional or portability and are not to be considered as limiting the scope of protection. Those skilled in the art can design the dimensions as desired, given the construction, operation and description of the invention. The term "aluminum-plastic blister capsule plate" as used herein may be used as appropriate, i.e., depending on the aluminum-plastic blister capsule plate to be accommodated. The aluminum-plastic blister capsule plate with the specifications commonly used in the market can be adopted, and the aluminum-plastic blister capsule plate with the specifications peculiar to different medicines of different manufacturers can also be adopted.

The shell is divided into a left part and a right part, wherein the left side is a first built-in groove used for containing a medicinal solid preparation, and the right side is a second built-in groove used for crushing the medicinal preparation to release medicinal particles or powder particles and allowing the medicinal particles or powder particles to be inhaled. The first built-in groove and the second built-in groove are arranged substantially vertically. Intermediate the first and second built-in grooves, a plurality of built-in holes are provided in a vertical direction, the built-in holes allowing a minimum unit of the pharmaceutical solid preparation to pass from the first built-in groove into the second built-in groove. The positions of the built-in holes correspond to the positions of the minimum units of the solid pharmaceutical preparations one by one. A typical aluminum plastic blister capsule plate contains two columns of the lowest unit formulation. Only one row can be cut and put in, and the built-in holes can be arranged in one row; the two rows can be placed into the aluminum-plastic blister capsule plate, the built-in holes can still be one row, after the aluminum-plastic blister capsule plate is used up, the aluminum-plastic blister capsule plate is taken out and inverted, the other remaining row can be aligned to the built-in holes, and the aluminum-plastic blister capsule plate in the second row can be conveniently used.

As a moisture-proof storage unit of the drug solid preparation, a moisture-proof procaterol hydrochloride powder medicament is slidably inserted into the first built-in groove. The powdered medicament referred to herein includes both powder and granular formulations. In addition, the outer side wall of the first built-in groove is provided with a telescopic extrusion structure for extruding the drug solid preparation to ensure that the minimum unit of the drug solid preparation enters the second built-in groove, and the telescopic extrusion structure specifically comprises: the fixed embedding has the lantern ring on the inner wall in first built-in groove, slides in the lantern ring and is provided with the push rod, and the push rod passes through first spring fixed connection with the casing, and the other end fixed mounting of push rod has the push pedal, push pedal and built-in hole one-to-one. The procaterol hydrochloride powder can be commercially available procaterol hydrochloride raw material micropowder or procaterol hydrochloride granules, such as procaterol hydrochloride granules of Heilongjiang Longde pharmaceutical industry Co. The procaterol hydrochloride raw material micro powder can be inhaled into respiratory tract to play a role, and the procaterol hydrochloride particles can be inhaled into oral cavity for administration. The procaterol hydrochloride granules can also be crushed into fine powder for quick absorption.

The moistureproof procaterol hydrochloride powder medicament can also be an aluminum-plastic bubble cap composite film bag medicament because of the requirements of moisture resistance, extrusion and pulverization, wherein each bubble hole of the aluminum-plastic bubble cap composite film bag medicament is internally provided with a composite film bag matched with the size of the bubble hole, and the composite film bag is internally provided with medicament powder particles. The composite film bags are commonly used granule packaging bags in the market, and particularly, the composite film bags are most commonly packaged in a four-edge sealing mode, a three-edge sealing mode and a back sealing mode (also called Stick packaging). The composite film bag may be a rod-shaped composite film bag as required by the bubble-hole structure. The aluminum-plastic blister composite film bag agent has the advantages of hardness of aluminum-plastic blisters, multi-unit separated packaging and easy rolling of the bar-shaped composite film bag in extrusion, and avoids the defect that the traditional composite film bag agent is difficult to extrude into the second built-in groove from the first built-in groove in extrusion deformation. Therefore, after the push rod is extruded, the minimum unit, namely the rod-shaped composite film bag can be extruded by the push plate to enable the rod-shaped composite film bag to leave the bubble hole, enter the second built-in groove through the built-in hole, and after the push rod is released, the push rod is reset by means of reverse rebounding of the first spring. The rod-shaped composite film bag can be prepared by rolling the composite film into a cylinder shape, heat sealing the side wall and the bottom wall, filling the powder in the cylinder, and heat sealing the top of the cylinder.

The moistureproof procaterol hydrochloride powder medicament can be an aluminum-plastic blister capsule because of the requirements of moisture resistance, extrusion and pulverization, 1 capsule matched with the size of a blister hole is arranged in each blister hole of the aluminum-plastic blister capsule, and medicament powder particles are filled in the capsule. Therefore, after the push rod is extruded, the capsule can leave the bubble hole through the extrusion of the push plate on the minimum unit, namely the capsule, enters the second built-in groove through the built-in hole, and after the push rod is released, the push rod is reset by means of reverse rebound of the first spring. The use of the aluminum-plastic blister capsule avoids the problem that the capsule can absorb moisture when the capsule is directly used, so that a plurality of capsules can be placed into the device at one time.

The shell is covered with a cover plate, the cover plate is provided with a vent hole, a vent hole rubber sleeve is fixedly bonded in the vent hole, and a vent hole rubber plug is movably inserted in the vent hole rubber sleeve. The establishment of an airway facilitates the passage of particles with the airflow into the oral cavity or respiratory tract. The setting of vent rubber buffer reduces the moisture when placing and gets into the device. In a preferable scheme, the non-woven cloth bag filled with water-absorbing silica gel particles or a covering waterproof breathable film can be plugged into the vent hole when the particles are absorbed. This is more effective. The vent hole can also be used for discharging drying moisture from the shell.

The capsule shell has small friction force, in order to prevent the capsule from being in poor contact with a crushing structure during crushing, a rod sleeve is fixedly embedded in the cover plate, an extrusion rod penetrates through the rod sleeve in a sliding manner, an extrusion block with a conical or arc-shaped bottom is fixedly installed at the lower end of the extrusion rod, an extrusion rod handle is arranged at the top of the extrusion rod, and the extrusion rod handle is fixedly connected with the upper surface of the cover plate through a second spring; so, can press the capsule that the extrusion pole handle extrusion got into the second built-in groove, make it and crushing structure good contact, be convenient for smash, when loosening the extrusion pole handle, the piece of extruding leaves capsule and crushing structure under the rebound effect of second spring direction.

An elastic card is fixedly arranged at one end or two ends of the cover plate, a clamping seat is fixedly arranged at the position of the upper part of the shell corresponding to the elastic card, and the elastic card is movably clamped with the clamping seat. The cover plate is disassembled and assembled by the elastic clamp and the movable clamp of the clamp seat. The insertion of moistureproof procaterol hydrochloride powder medicaments and the like and the operations of cleaning, replacing, airing and the like of the internal structure are facilitated.

As a crushing structure, the second built-in groove is internally provided with a first supporting shaft and a second supporting shaft in a rotating mode respectively, the first supporting shaft is fixedly provided with a first crushing roller, the second supporting shaft is fixedly provided with a second crushing roller, the two crushing rollers are fixedly connected with teeth, the teeth of the first crushing roller are meshed with the teeth of the second crushing roller and are connected, two sides of the two crushing rollers are in contact with the inner wall of the second built-in groove respectively, the outer end of the first supporting shaft is fixedly provided with a linkage gear, the outer end of the second supporting shaft is fixedly connected with a driving gear and a rocker respectively, and the driving gear is meshed with the linkage gear. The teeth of the crushing roller can be sharp teeth with triangular cross sections or blunt teeth with trapezoidal cross sections. The triangular sharp teeth are preferred.

As another kind of crushing structure, it is provided with first back shaft and second back shaft to rotate respectively in the built-in inslot of second, fixed mounting has first crushing roller on the first back shaft, fixed mounting has second crushing roller on the second back shaft, equal fixedly connected with cutting edge of cutting usefulness on two crushing rollers, the cutting edge of first crushing roller is the overlap setting with the cutting edge of second crushing roller, the both sides of two crushing rollers are the inner wall contact of the built-in groove of second respectively, the outer end fixed mounting of first back shaft has the linkage gear, the outer end of second back shaft is fixedly connected with drive gear and rocker respectively, drive gear and linkage gear meshing are connected.

The second built-in inslot fixed mounting has two mesh hang plates, and the mesh hang plate can be made by the plastic slab that is equipped with intensive through-hole, and the mesh can reduce the hindrance to the air current, and the plastic slab can alleviate the weight of device, and the mesh hang plate plays the guide effect, will follow the leading-in crushing structure of pharmaceutical preparation unit that first built-in groove gets into the second built-in groove via built-in hole, improves work efficiency. The upper ends of the two mesh inclined plates are respectively clung to the inner wall of the second built-in groove, and the lower ends of the two mesh inclined plates are arranged right above the middle of the first crushing roller and the second crushing roller to form a gap matched with the built-in hole; the filter screen is fixedly arranged in the second built-in groove and is positioned below the first crushing roller and the second crushing roller. The filter screen can isolate the pulverized medicament from the upper part and only allow the medicament particles to enter the lower part. A suction nozzle is fixedly embedded in one side of the bottom of the second built-in groove, which is opposite to the first built-in groove, and a suction nozzle cover is movably sleeved at an outlet of the suction nozzle. The bottom of the second built-in groove is provided with an inclined plane at the position right facing the suction nozzle. The arrangement of the inclined surface facilitates the movement of the medicine powder particles to the suction nozzle along the inclined surface, is beneficial to the suction of the powder particles and reduces the powder particle residue.

Compared with the existing inhalation device, the procaterol hydrochloride solid preparation administration device has the following beneficial effects:

first, the first internal groove and the second internal groove communicate with each other via the internal hole, and a plurality of doses of the pharmaceutical solid preparation can be inserted into the first internal groove. Moreover, the structure enables the first built-in groove to be inserted with a drug solid preparation with a moisture-proof package, thereby allowing multiple doses to be carried and taken, and also allowing long-term storage without taking out one tablet at a time and putting in the device, and cleaning the residual solid preparation package after use; when the device is used for the second time, one particle is taken out again and put into the device, thus the operation is complicated. The one-to-one correspondence of the built-in holes, push plate and blister makes it unnecessary to pull the dosage unit, i.e. the capsule plate, repeatedly.

Secondly, the first built-in groove and the second built-in groove are separately arranged, so that the storage and the crushing of the solid medicine preparation are separated, the minimum units of the preparations such as capsules and composite membrane bags are separated by the filter screen and temporarily stored above the filter screen of the second built-in groove after the second built-in groove is crushed, 6-12 minimum units are used, namely the cover plate can be opened after 1 to 4 days to uniformly package the medicines and put the medicines into the garbage can, the environment pollution is avoided, and the operation frequency of cleaning is reduced. And the procaterol hydrochloride raw material micro powder or procaterol hydrochloride particles can be selected according to requirements. The aluminum-plastic bubble plate is stored and crushed in different cavities respectively, and the medicine powder particles have unique airflow channels, so that the sucking effect is stable, and the medicine unit, namely the capsule plate, does not need to be moved repeatedly.

And thirdly, the vent hole, the reticular guide plate, the filter screen, the inclined plane at the bottom of the second built-in groove and the suction nozzle form an airflow channel, when the suction device is used, the vent hole and the suction nozzle are opened, air is sucked from the suction nozzle, and the powder particles are sucked into the oral cavity or the respiratory tract along with the airflow.

Finally, the medicament is usually in a moisture-proof package, so that the medicament can be prevented from being affected with moisture; the aluminum-plastic bubble cap can reduce the weight of the device and is convenient to carry, and the aluminum-plastic bubble cap is not as fragile as a bottle. And the medicines in the aluminum-plastic blister are stored in divided doses, so that the dose does not need to be adjusted in the device, and the difficulty of using and operating is reduced. The mesh inclined plate can not only play a guiding role for the medicine capsule or the composite film bag, but also participate in gas turbulence and vortex. The crushing roller is beneficial to full release of the medicine powder particles from the medicine capsule or the composite film bag, and the medicine powder particles are released more thoroughly than the medicine powder particles released by the puncture structure and the incision structure.

The procaterol hydrochloride solid preparation administration device is suitable for carrying administration during travel, is convenient to carry and not easy to lose, and reduces the complex operation degree and environmental pollution.

Drawings

Fig. 1 is a schematic view of the overall structure of the present invention;

FIG. 2 is a partially enlarged schematic view of two built-in grooves of the present invention;

fig. 3 is a schematic top view distribution of two pulverizing rollers according to the present invention;

FIG. 4 is a schematic diagram of one embodiment of the moisture-resistant procaterol hydrochloride powder dosage form of the present invention;

FIG. 5 is a schematic diagram of another embodiment of the moisture-resistant procaterol hydrochloride powder dosage form of the present invention;

fig. 6 is a second schematic top view of the distribution of the two pulverizing rollers of the present invention.

In the figure: 1 shell, 11 first built-in groove, 12 second built-in groove, 13 built-in hole, 14 moistureproof procaterol hydrochloride powder medicament, 141 capsule, 142 composite film bag, 15 lantern ring, 16 push rod, 17 first spring, 18 push plate, 2 cover plate, 21 vent hole, 22 vent hole rubber sleeve, 23 vent hole rubber plug, 3 rod sleeve, 31 extrusion rod, 32 extrusion block, 33 elastic card, 34 clamping seat, 35 second spring, 36 extrusion rod handle, 4 first support shaft, 41 second support shaft, 42 first crushing roller, 43 second crushing roller, 44 second support shaft, 45 linkage gear, 46 drive gear, 47 rocker, 5 mesh inclined plate, 51 filter screen, 52 suction nozzle and 53 suction nozzle cover.

Detailed Description

The present delivery device is described in more detail below with reference to the accompanying drawings. It is noted that the procaterol hydrochloride solid preparation administration device is actually a device for inhalation administration of a solid preparation of a powdery or granular drug. Therefore, the device is also suitable for inhalation administration of powder and granular solid pharmaceutical preparations of other oral and respiratory medicaments besides procaterol hydrochloride, such as tiotropium bromide inhalation powder and budesonide inhalation powder. Thus, the moisture-resistant procaterol hydrochloride powder medicament 14 described below is merely a name for one embodiment, and may also be referred to as a moisture-resistant tiotropium bromide powder medicament, a moisture-resistant budesonide powder medicament, in additional embodiments. These are all available on the market. The moisture-resistant procaterol hydrochloride powder medicament 14 can therefore also be referred to as a moisture-resistant medicament powder medicament.

EXAMPLE 1 administration device suitable for solid Procarpterol hydrochloride formulations

Referring to fig. 4 and 5, fig. 4 is a schematic structural diagram of two kinds of moistureproof procaterol hydrochloride powder medicaments suitable for the present invention, wherein the moistureproof procaterol hydrochloride powder medicament 14 of fig. 4 is an aluminum-plastic blister capsule, each blister cavity of the aluminum-plastic blister capsule is filled with 1 capsule 141 with a size matched with that of the blister cavity, and the capsule is filled with medicament powder particles. The moistureproof procaterol hydrochloride powder medicament 14 shown in the figure 5 is an aluminum-plastic bubble-cap composite film bag, a composite film bag 142 matched with the bubble holes in size is arranged in each bubble hole of the aluminum-plastic bubble-cap composite film bag, and medicament powder particles are arranged in the composite film bag. The composite film bag is a rod-shaped composite film bag.

Fig. 1 to 3 show a schematic structural diagram of a procaterol hydrochloride solid preparation administration device of the present invention. A first built-in groove 11 and a second built-in groove 12 are formed in a shell 1 of a procaterol hydrochloride solid preparation drug delivery device, the first built-in groove 11 is communicated with the second built-in groove 12 through a plurality of built-in holes 13, a moistureproof procaterol hydrochloride powder medicament 14 is inserted into the first built-in groove 11 in a sliding mode, a lantern ring 15 is fixedly embedded into the inner wall of the first built-in groove 11, a push rod 16 is arranged in the lantern ring 15 in a sliding mode, the push rod 16 is fixedly connected with the shell 1 through a first spring 17, a push plate 18 is fixedly mounted at the other end of the push rod 16, and the push plate 18 corresponds to the built-in holes 13 one to one. The side wall of the first built-in groove 11 provided with the lantern ring 15 can be made of transparent plastic materials, so that whether the inner medicament is extruded or not can be conveniently observed.

The shell 1 is covered with a cover plate 2, the cover plate 2 is provided with a vent hole 21, a vent hole rubber sleeve 22 is fixedly bonded in the vent hole 21, and a vent hole rubber plug 23 is movably inserted in the vent hole rubber sleeve 22.

A rod sleeve 3 is fixedly embedded in the cover plate 2, an extrusion rod 31 penetrates through the rod sleeve 3 in a sliding manner, an extrusion block 32 with a conical or arc-shaped bottom is fixedly installed at the lower end of the extrusion rod 31, an extrusion rod handle 36 is arranged at the top of the extrusion rod 31, and the extrusion rod handle 36 is fixedly connected with the upper surface of the cover plate 2 through a second spring 35; an elastic clamp 33 is fixedly arranged at one end or two ends of the cover plate 2, a clamping seat 34 is fixedly arranged at the upper part of the shell 1, and the elastic clamp 33 is movably clamped with the clamping seat 34.

As shown in fig. 1 and 3, a first supporting shaft 4 and a second supporting shaft 41 are respectively rotatably arranged in the second built-in groove 12, a first crushing roller 42 is fixedly mounted on the first supporting shaft 4, a second crushing roller 43 is fixedly mounted on the second supporting shaft 41, teeth of the first crushing roller 42 are meshed with teeth of the second crushing roller 43, two sides of the two crushing rollers are respectively contacted with the inner wall of the second built-in groove 12, a linkage gear 45 is fixedly mounted at the outer end of the first supporting shaft 4, a driving gear 46 and a rocker 47 are respectively fixedly connected at the outer end of the second supporting shaft 41, and the driving gear 46 is meshed with the linkage gear 45. Specifically, as shown in fig. 3, two through holes and two blind holes may be provided in the side wall of the second built-in groove 12 for insertion-mounting the first support shaft 4 and the second support shaft 41 and facilitating the rotation of the first support shaft 4 and the second support shaft 41.

Two mesh inclined plates 5 are fixedly arranged in the second built-in groove 12, the upper ends of the two mesh inclined plates 5 are respectively clung to the inner wall of the second built-in groove 12, and the lower ends of the two mesh inclined plates 5 are right above the middle of the first crushing roller 42 and the second crushing roller 43 to form a gap matched with the built-in hole 13; a filter screen 51 is fixedly arranged in the second built-in groove 12, the filter screen 51 is positioned below the first crushing roller 42 and the second crushing roller 43, a suction nozzle 52 is fixedly embedded in one side of the bottom of the second built-in groove 12, which is opposite to the first built-in groove 11, and a suction nozzle cover 53 is movably sleeved at the outlet of the suction nozzle 52; the bottom of the second built-in groove 12 is provided with an inclined surface at a position facing the suction nozzle 52.

The utility model discloses when concrete implementation: firstly, the cover plate 2 is opened, the moistureproof procaterol hydrochloride powder medicament 14 is slidably inserted into the first built-in groove 11, so that the minimum preparation units of the moistureproof procaterol hydrochloride powder medicament 14 correspond to the built-in holes one by one, and then the cover plate 2 and the shell 1 can be fixed by clamping the clamping seat 34 through the elastic card 33. When the medicine powder needs to be inhaled in the later period, the push rod 16 is pressed, the push rod 16 drives the push plate 18 to extrude the moistureproof procaterol hydrochloride powder medicament 14, so that the minimum preparation unit in the moistureproof procaterol hydrochloride powder medicament 14, such as an aluminum foil extruded by a capsule or a rod-shaped composite film bag, enters the second built-in groove 12 through the built-in hole 13 and falls to the positions of the two crushing rollers, the position of the extrusion block 32 is adjusted if necessary to be pressed on the capsule, one hand presses the extrusion rod 31, the other hand shakes the rocker 47 to simultaneously move the two crushing rollers inwards, the composite film bag behind the capsule is crushed, the medicine micro powder or particles are released, the powder particles pass through the filter screen 51 and are concentrated along the position facing the suction nozzle 52, and finally the vent 21 is opened to suck the medicine through the suction nozzle 52. The nozzle cover 53 is covered after the medicine is sucked. The procaterol hydrochloride particles can be sucked into the oral cavity and deposited in the oral cavity for absorption, at the moment, the tongue tip can be propped against the palate when the procaterol hydrochloride particles are sucked, the suction nozzle 52 is held to suck the particles into the oral cavity, and the medicine is deposited in the oral cavity and released. The procaterol hydrochloride micro powder can be inhaled into the respiratory tract, and at the moment, the procaterol hydrochloride micro powder can be breathed in by holding the suction nozzle 52 after being spit, and the micro powder enters the respiratory tract along with the airflow.

After the minimum preparation unit, such as a capsule or a rod-shaped composite film bag, in the moistureproof procaterol hydrochloride powder medicament 14 is used, the cover plate is opened, the aluminum-plastic bubble cap is taken out, and the packaging fragments are poured out from the second built-in groove and put into a garbage can.

EXAMPLE 2 drug delivery device suitable for solid Procarpterol hydrochloride formulations

As shown in fig. 6, the administration device for a solid procaterol hydrochloride preparation according to example 1 is configured such that teeth provided on the first and second crushing

rollers

42 and 43 are replaced with circular blades; the annular blades are fixedly wound on the outer walls of the first crushing roller 42 and the second crushing roller 43; the outer walls of the first crushing roller 42 and the second crushing roller 43 are respectively provided with 2-10 circular blades, the circular blades of the first crushing roller 42 and the second crushing roller 43 are staggered, and the middle positions of the two crushing rollers are in a mutually overlapped state, so that the capsule 141 or the composite film bag 142 falling on the two crushing rollers can be fully extruded and cut, and the medicine powder or the medicine particles in the capsule 141 or the composite film bag 142 can be released.

Of course, the blades provided on the first and

second pulverizing rollers

42 and 43 may have a fan shape.

The cutting edge is used as a cutting mode, the size of the scraps of the capsule 141 or the composite film bag 142 is relatively fixed during cutting, and the generation of the excessively small scraps can be prevented.

The other structures of the administration device suitable for the procaterol hydrochloride solid preparation are the same as those in example 1.

Claims

1. A procaterol hydrochloride solid preparation administration device comprising a housing (1), characterized in that: be provided with first built-in groove (11) and second built-in groove (12) on casing (1), first built-in groove (11) and second built-in groove (12) are through a plurality of built-in holes (13) intercommunication, it has dampproofing procaterol hydrochloride powder medicament (14) to slide to insert in first built-in groove (11), fixed embedding has lantern ring (15) on the inner wall of first built-in groove (11), it is provided with push rod (16) to slide in lantern ring (15), push rod (16) and casing (1) are through first spring (17) fixed connection, the other end fixed mounting of push rod (16) has push pedal (18), push pedal (18) and built-in hole (13) one-to-one.

2. The procaterol hydrochloride solid formulation drug delivery device according to claim 1, wherein: the moistureproof procaterol hydrochloride powder medicament (14) is an aluminum-plastic bubble cap composite film bag, a composite film bag (142) matched with the size of each bubble hole is arranged in each bubble hole of the aluminum-plastic bubble cap composite film bag, and medicine powder is filled in the composite film bag.

3. The procaterol hydrochloride solid formulation drug delivery device according to claim 2, wherein: in the aluminum-plastic bubble cap composite film bag agent, the composite film bag is a rod-shaped composite film bag.

4. The procaterol hydrochloride solid formulation drug delivery device according to claim 1, wherein: the moistureproof procaterol hydrochloride powder medicament (14) is an aluminum-plastic bubble cap capsule, 1 capsule (141) matched with the size of each bubble hole is arranged in each bubble hole of the aluminum-plastic bubble cap capsule, and medicament powder particles are filled in the capsules.

5. The procaterol hydrochloride solid formulation drug delivery device according to any one of claims 2 to 4, wherein: the air vent is characterized in that a cover plate (2) covers the shell (1), an air vent (21) is arranged on the cover plate (2), an air vent rubber sleeve (22) is fixedly bonded in the air vent (21), and an air vent rubber plug (23) is movably inserted into the air vent rubber sleeve (22).

6. The procaterol hydrochloride solid formulation drug delivery device according to claim 5, wherein: a rod sleeve (3) is fixedly embedded in the cover plate (2), an extrusion rod (31) penetrates through the rod sleeve (3) in a sliding mode, an extrusion block (32) with a conical or arc-shaped bottom is fixedly installed at the lower end of the extrusion rod (31), an extrusion rod handle (36) is arranged at the top of the extrusion rod (31), and the extrusion rod handle (36) is fixedly connected with the upper surface of the cover plate (2) through a second spring (35); one end or two ends of the cover plate (2) are fixedly provided with elastic clamps (33), the upper part of the shell (1) is fixedly provided with a clamping seat (34), and the elastic clamps (33) are movably clamped with the clamping seat (34).

7. The procaterol hydrochloride solid formulation drug delivery device according to claim 6, wherein: rotate respectively in the second built-in groove (12) and be provided with first supporting shaft (4) and second back shaft (41), fixed mounting has first crushing roller (42) on first supporting shaft (4), fixed mounting has second crushing roller (43) on second back shaft (41), the outer wall fixedly connected with tooth or the cutting edge of first crushing roller (42) and second crushing roller (43), the both sides of two crushing rollers are the inner wall contact of second built-in groove (12) respectively, the outer end fixed mounting of first supporting shaft (4) has linkage gear (45), the outer end of second back shaft (41) is fixedly connected with drive gear (46) and rocker (47) respectively, drive gear (46) are connected with linkage gear (45) meshing.

8. The procaterol hydrochloride solid formulation drug delivery device according to claim 7, wherein: teeth are fixedly connected to the outer walls of the first crushing roller (42) and the second crushing roller (43), and the teeth of the first crushing roller (42) are meshed with the teeth of the second crushing roller (43).

9. The procaterol hydrochloride solid formulation drug delivery device according to claim 7, wherein: the outer walls of the first crushing roller (42) and the second crushing roller (43) are fixedly connected with blades, and the blades of the first crushing roller (42) and the blades of the second crushing roller (43) are arranged in an overlapped mode.

10. A procaterol hydrochloride solid formulation drug delivery device according to any one of claims 6 to 9, wherein: two mesh inclined plates (5) are fixedly arranged in the second built-in groove (12), the upper ends of the two mesh inclined plates (5) are respectively clung to the inner wall of the second built-in groove (12), and the lower ends of the two mesh inclined plates (5) are arranged right above the middle of the first crushing roller (42) and the second crushing roller (43) to form a gap matched with the built-in hole (13); a filter screen (51) is fixedly arranged in the second built-in groove (12), the filter screen (51) is positioned below the first crushing roller (42) and the second crushing roller (43), a suction nozzle (52) is fixedly embedded into one side of the bottom of the second built-in groove (12) opposite to the first built-in groove (11), and a suction nozzle cover (53) is movably sleeved at an outlet of the suction nozzle (52); the bottom of the second built-in groove (12) is provided with an inclined surface at the position facing the suction nozzle (52).