CN214343813U

CN214343813U - Medicinal inhalation device and blister strip for use therein

Info

Publication number: CN214343813U
Application number: CN202022810219.1U
Authority: CN
Inventors: 博江盟; 董可立; 王祎哲; 鲍勃卡斯珀
Original assignee: CF PHARMTECH Inc
Current assignee: CF PHARMTECH Inc
Priority date: 2020-11-27
Filing date: 2020-11-27
Publication date: 2021-10-08
Anticipated expiration: 2030-11-27

Abstract

A medicinal inhalation device and a blister strip for use therein are provided, wherein the medicinal inhalation device comprises a housing, and a transmission mechanism, a delivery mechanism, a piercing mechanism and an inhalation mechanism located within the housing. The housing is configured to receive a blister strip storing capsules; the transmission mechanism is configured to transport capsules to be delivered in the blister strip to a predetermined position; the delivery mechanism is configured to push out of the blister strip a capsule to be delivered in the blister strip from the predetermined position and deliver to a piercing mechanism; and the piercing mechanism is configured to pierce a capsule located within the piercing mechanism to enable medicament in the capsule to enter a human body through the inhalation mechanism upon inhalation by a user. A blister strip for use in the medicinal inhalation device described above is also provided.

Description

Medicinal inhalation device and blister strip for use therein

Technical Field

The utility model relates to the technical field of medical equipment, particularly, relate to a medicine suction device to and use the bubble cap strip in this medicine suction device.

Background

A dry powder inhaler is a formulation that actively inhales micronized drug or carrier in capsules, vesicles or multi-dose reservoirs by the patient using a specially designed inhalation device. The dry powder inhalant is used as a pulmonary administration preparation and is clinically used for treating local pulmonary diseases such as asthma, chronic obstructive disease, cystic fibrosis and the like. In recent years, pulmonary administration represented by dry powder inhalants has become a new way for non-invasive administration of polypeptide and protein drugs, because alveolar epithelial cells have the characteristics of thin cell walls, large absorption area, large blood flow, low metabolic activity of enzymes, capability of reducing first-pass effect and the like. Because the dry powder inhalant does not use a propellant, the damage of the propellant to the atmospheric ozone layer can be avoided, the administration is convenient, the dosage is accurate, the effect is better, and particularly, the ideal bioavailability can be realized after some biological macromolecules are inhaled into the lung for administration.

The use of dry powder inhalers requires the use of a drug inhalation device which does not require an additional propellant or propellant, typically to deliver a metered dose of drug into the airflow inhaled by the patient to ultimately effect pulmonary delivery. Currently common medicinal inhalation devices are mainly divided into three categories: (1) reservoir-based drug inhalation; (2) pre-dose multi-dose drug inhalation, multiple use blister type; (3) single dose dry powder inhalation, capsule type, is commonly used.

In the three types of medicinal inhalation devices described above, reservoir-type medicinal inhalation devices are constructed with a powder reservoir for volume-divided inhalation of medicinal powder each time it is used. The device has high requirements on powder flowability, and the dry powder in the storage is very sensitive to permeated moisture, so that a drying agent needs to be added into the device to prevent the possible adverse effect caused by external moisture. For single dose medicinal inhalation devices, the principle of operation is to place a medicament capsule into the inhaler during use, where the capsule is rotated by the inhaled air stream after being pierced by a needle, releasing the medicament particles contained therein. The device has simple structure, convenient use and low internal resistance, but has the defects that the device needs to be charged every time when in use, the moisture resistance is poor, and the output quantity is influenced because the medicinal powder is easily affected by moisture and solidification.

The pre-dose multi-dose medicinal inhalation device has its distinct advantages over the two medicinal inhalation devices described above. The pre-dose multi-dose medicine inhalation device mostly uses a blister type by sealing powder of medicine in a blister of a disk-shaped conveyor belt made of aluminum foil and winding the conveyor belt on a turntable device. Because each dosage unit is individually packaged and sealed, the drug is protected from environmental factors such as temperature and humidity, and the dosage of the drug can be accurately controlled.

However, in conventional pre-dosed multi-dose medicinal inhalation devices, a dedicated blister is required, which is relatively complex and expensive to construct.

It can thus be seen that there is a need in the art for an improved medicinal inhalation device.

SUMMERY OF THE UTILITY MODEL

In view of the problems in the prior art, embodiments of the present invention provide an improved medicinal inhalation device that at least partially alleviates or eliminates one or more of the disadvantages of the prior art.

In one aspect of the present invention, a medicinal inhalation device is provided, comprising a housing, and a transmission mechanism, a delivery mechanism, a piercing mechanism, and an inhalation mechanism located within the housing. The housing is configured to receive a blister strip storing capsules; the transmission mechanism is configured to transport capsules to be delivered in the blister strip to a predetermined position; the delivery mechanism is configured to push out of the blister strip a capsule to be delivered in the blister strip from the predetermined position and deliver to a piercing mechanism; and the piercing mechanism is configured to pierce a capsule located within the piercing mechanism to enable medicament in the capsule to enter a human body through the inhalation mechanism upon inhalation by a user.

According to an exemplary embodiment of the invention, the delivery mechanism comprises an advancing part configured to advance a capsule located in the blister part at the predetermined position to the piercing mechanism.

According to an exemplary embodiment of the present invention, the propelling part comprises a push rod configured to propel the capsule located at the predetermined position in response to a pressing, and a push rod spring configured to reset the push rod in response to the pressing being removed.

According to an exemplary embodiment of the invention, the delivery mechanism comprises a rotating claw profile configured to pierce the blister strip in response to being rotated and to deliver the capsule to be delivered to the piercing mechanism by rotation.

According to an exemplary embodiment of the present invention, the transmission mechanism includes a driving gear, a first driven gear and a blister strip transmission wheel, the driving gear is configured to drive the first driven gear to rotate, and the blister strip transmission wheel is configured to transmit under the drive of the first driven gear the blister strip.

According to an exemplary embodiment of the present invention, the transmission mechanism further comprises a first ratchet mechanism configured to drive the driving gear to rotate.

According to an exemplary embodiment of the present invention, the above drug inhalation device further comprises a protective cover configured to cover the inhalation mechanism in a closed state and to actuate the first ratchet mechanism in an open state.

According to an exemplary embodiment of the present invention, the transmission mechanism further comprises a second driven gear and a blister strip recovery wheel, the driving gear is further configured to drive the second driven gear to rotate, and the blister strip recovery wheel is configured to recover the portion of the blister strip after the drug has been delivered under the drive of the second driven gear.

According to an exemplary embodiment of the present invention, the puncture mechanism includes a puncture chamber, an actuation knob, a paddle, a hollow shaft, a rotation chamber, a knob spring, a sliding cam, and a puncture needle. The puncture cavity is connected to the transmission mechanism, configured to receive a capsule from the predetermined location; the actuation knob is configured to deliver the capsule from a side of the puncture cavity proximate the advancing mechanism to a side proximate the inhaling mechanism in response to rotation, and to deliver the capsule located within the puncture cavity to the rotation cavity through the paddle and the hollow shaft in response to depression. The knob spring is configured to reset the actuation knob in response to the depression being removed. The sliding cam is located within the rotating cavity and is configured to drive the piercing needle to pierce a capsule located within the piercing cavity.

According to an exemplary embodiment of the invention, the actuation knob is equipped with a second ratchet mechanism configured to ensure a unidirectional rotation of the actuation knob.

According to an exemplary embodiment of the present invention, the suction mechanism comprises a suction nozzle and a pin, the suction nozzle being connected with the puncture mechanism through the pin.

According to an exemplary embodiment of the present invention, the suction nozzle is provided with a mesh portion.

In another aspect of the present invention, there is provided a blister strip for use in any one of the above-mentioned medicinal inhalation devices, the blister strip comprising at least one blister portion and a flexible portion configured to carry the at least one blister portion, each blister portion containing a capsule of a single inhaled quantity of medicament, the blister strip being stored inside the housing.

According to an exemplary embodiment of the present invention, the blister strip is used in a medicine inhalation device employing a rotating jaw piece, and a slope of one side of each of the blister parts contacting with the rotating jaw piece is smaller than an opposite side of the blister part.

According to an exemplary embodiment of the present invention, the specifications of the capsules in the blister strip include No. 5, No. 4, No. 3, No. 2, No. 1, No. 0, No. 00, No. 000.

In contrast to the prior art, the present invention provides a drug inhalation device that employs a capsule filling technique to pre-meter the dosage of drug in a capsule and uses a certain number of capsules (e.g., 30 or 60) to form a complete drug storage structure for multiple doses to be delivered accurately in sequence from a single drug storage structure. Combining multiple capsules together in a single drug storage structure enables the use of relatively inexpensive and mature capsule dosing techniques, thereby ensuring a validated dosing of the drug and protecting the drug from environmental factors such as temperature or humidity.

Further, embodiments of the present invention provide a medicinal inhalation device that is compatible with well-established standard manufacturing processes for filling capsules and packaging them in blisters, and that has fewer limitations on the amount of medicament that can be delivered and a simpler design of blister strips than conventional blister-type medicinal inhalation devices.

It is to be understood that both the foregoing general description and the following detailed description are exemplary and explanatory only and are not intended to limit the invention in any manner.

Drawings

These and other aspects of the present invention will now be described in more detail, with reference to the appended drawings showing embodiments of the invention, which are not necessarily to scale, but are instead focused on illustrating the principles of the invention. In the drawings:

figure 1 schematically illustrates an external view of a medicinal inhalation device according to an exemplary embodiment of the present invention;

figure 2 schematically illustrates an internal cross-sectional view of a medicinal inhalation device according to an exemplary embodiment of the present invention, in which the storage, delivery and retrieval of the blister strip is particularly illustrated;

figure 3 schematically illustrates an internal cross-sectional view of a medicinal inhalation device according to an exemplary embodiment of the present invention, wherein the transmission mechanism, the delivery mechanism and the propulsion portion are illustrated in detail;

fig. 4 schematically illustrates a sectional view in a bottom direction of a medicinal inhalation device according to an exemplary embodiment of the present invention, wherein the puncturing mechanism, the delivery mechanism and the propulsion portion are illustrated in detail;

FIG. 5 illustrates the lancing mechanism shown in FIG. 4 in greater detail;

FIG. 6 illustrates the slide cam as shown in FIGS. 4 and 5 in more detail;

figure 7 schematically illustrates an inhalation mechanism of a medicinal inhalation device according to an exemplary embodiment of the present invention;

figure 8 schematically illustrates a delivery mechanism of a medicinal inhalation device according to another exemplary embodiment of the present invention;

figure 9 schematically illustrates an actuation knob and a paddle in a piercing mechanism of a medicinal inhalation device according to an exemplary embodiment of the present invention;

figure 10 schematically illustrates the manner of action of the paddle and hollow shaft of a medicinal inhalation device according to an exemplary embodiment of the present invention;

figure 11 schematically illustrates a rotary cavity of a drug inhalation device according to an exemplary embodiment of the present invention;

figure 12 schematically illustrates a ratchet mechanism according to an exemplary embodiment of the present invention; and

fig. 13 schematically illustrates a mesh portion of the inhalation mechanism according to an exemplary embodiment of the present invention.

Like reference numerals are used to refer to like parts throughout the various figures.

Some embodiments of the invention have been illustrated by the accompanying drawings and described in more detail below. The drawings and the description are not intended to limit the scope of the inventive concept in any way, but rather to illustrate the inventive concept by those skilled in the art with reference to specific embodiments.

Detailed Description

In order to make the purpose, technical solution and advantages of the embodiments of the present invention clearer, the drawings of the embodiments of the present invention are combined below to clearly and completely describe the technical solution of the embodiments of the present invention. It is to be understood that the embodiments described are only some of the embodiments of the present invention, and not all of them. All other embodiments, which can be obtained by a person skilled in the art without any inventive work based on the described embodiments of the present invention, belong to the protection scope of the present invention.

The embodiment of the present invention provides a medicine inhalation device, as shown in fig. 1, which has a housing 1, a rotatable protection cover 2, a push rod 3, a pressing knob 4, a mouthpiece 5 and a rotary chamber 6, as viewed from the outside. The protective cover 2 is rotatably closed and opened, and when in a closed state, the protective cover 2 covers the suction nozzle 5 to prevent the suction nozzle 5 from being contaminated. When the user needs to take a medicine inhalation, the protective cap 2 is opened to expose the mouthpiece 5. Alternatively, the mouthpiece 5 may be folded in the protective cover 2 to further ensure cleanliness at the mouthpiece 5.

The medicinal inhalation device shown in figure 1 is used with a blister strip carrying capsules. Figure 2 schematically illustrates the storage, delivery and retrieval of the blister strip inside the medicinal inhalation device. As shown in fig. 2, a blister strip 19 storing a plurality of capsules is rolled into a disk shape to be accommodated in the housing 1, and the medicine in the capsules is supplied to the user through a transmission mechanism, a delivery mechanism, a piercing mechanism, and an inhalation mechanism inside the housing 1. In particular, the transmission mechanism is configured to transport the capsules to be delivered in the blister strip 19 to a predetermined position, the delivery mechanism is configured to push the capsules to be delivered in the blister strip 19 out of the blister strip 19 from the predetermined position and deliver them to the piercing mechanism, and the piercing mechanism is configured to pierce the capsules located within the piercing mechanism, enabling the medicament in the capsules to pass through the inhalation mechanism into the body under inhalation by the user. The user inhales the medicament through the inhalation mechanism.

In particular, fig. 3 schematically illustrates a transmission mechanism according to an exemplary embodiment of the present invention. As shown in fig. 2 and 3, the transmission mechanism comprises a driving gear 15, a first driven gear 9 and a blister strip transfer wheel 17, the driving gear 15 being configured to rotate the first driven gear 9, the first driven gear 9 in turn rotating the blister strip transfer wheel 17, thereby transferring the blister strip 19 in order to transfer the capsules to be delivered to the predetermined position. In the embodiment shown in fig. 2, the predetermined position is aligned with the pushing direction of the push rod 3. In a specific implementation, specific parameters of each gear can be set according to the adjacent distance between blisters on the blister strip, and the corresponding gear model is selected to realize accurate feeding of capsules in the blisters, so that the capsules to be delivered are conveyed to a specific position.

Optionally, as shown in fig. 3, the transmission mechanism may further include a first ratchet mechanism 7, and the first ratchet mechanism 7 may rotate the driving gear 15 so as to actuate the driving gear 15. Further alternatively, the driving gear 15 may be connected to the protective cover 2 by the first ratchet mechanism 7. Specifically, fig. 12 exemplarily illustrates the structure of the first ratchet mechanism 7, including two interacting ratchets. The first ratchet 38 is keyed to the protective cover 2 and rotates with the rotation of the protective cover 2. The second ratchet wheel 37 is engaged with the first ratchet wheel 38, and when the protective cover 2 is opened, the first ratchet wheel 38 can drive the second ratchet wheel 37 to rotate, and the second ratchet wheel 37 can drive the driving gear 15 to rotate, thereby driving the transmission mechanism. When the protective cover 2 is closed, the first ratchet 38 cannot drive the second ratchet 37 due to the change of the rotation direction of the first ratchet 38, so that the transmission mechanism is not operated when the protective cover 2 is closed, and the used blister strip cannot be returned to the position before use. In such an embodiment, the protective cap 2 not only protects but also activates the actuator, thereby eliminating other components dedicated to activating the actuator, not only simplifying the structure of the medicinal inhalation device, but also reducing the cost of the medicinal inhalation device. Meanwhile, ratchet wheel drive is used between the protective cover 2 and the driving gear 15, so that the protective cover cannot cause the blister strip to retreat to the original position in use when being closed, and the continuity of use at each time is ensured.

Of course, it should be understood by those skilled in the art that the manner in which the drive gear is driven by the protective cover and the ratchet mechanism is merely one example. Various other ways of directly driving the drive gear to transfer the blister strip will be apparent to those skilled in the art in view of the teachings of the present invention.

In actual use, if the length of the blister strip 19 is long, it is necessary to recover the portion of the blister strip 19 after delivery of the capsule in the housing 1 so as not to interfere with the transport of the remainder of the blister strip 19. In view of this, the transmission mechanism may optionally further comprise a second driven gear 11 and a blister strip retraction wheel 18, as shown in fig. 2 and 3. The driving gear 15 is also configured to rotate the second driven gear 11, the second driven gear 11 in turn driving the blister strip recovery wheel 18, so as to recover the portion of the blister strip 19 after the medicament has been delivered, which is wound on the blister strip recovery wheel 18, so as to avoid affecting the transmission of the remaining portion of the blister strip 19.

Fig. 2 and 3 also schematically illustrate the delivery mechanism of a medicinal inhalation device according to an exemplary embodiment of the present invention. In particular, the delivery mechanism comprises an advancing portion configured to advance the capsule in the blister located at the predetermined position to the piercing mechanism. As shown in fig. 2 and 3, the pusher section includes the push rod 3 and push rod springs 13, 14. After the blister strip 19 has been transferred to the predetermined position by the transmission mechanism, the push rod 3 can be manually pushed to advance the capsule in the blister into the piercing mechanism. When the push rod 3 is released, the push rod 3 will be reset due to the action of the push rod springs 13 and 14.

Alternatively, the side surface of the push rod 3 close to the blister portion may have a concave shape to better match and contact the convex outer surface of the blister portion for effective propulsion of the capsule.

Fig. 4 and 5 schematically illustrate a piercing mechanism of a medicinal inhalation device according to an exemplary embodiment of the present invention. As shown in fig. 4 and 5, the puncture mechanism includes a puncture chamber 21, an actuation knob 4, a paddle 24 (specifically, as shown in fig. 9), a rotation chamber 6 (specifically, as shown in fig. 11), a knob spring 20, a slide cam 8, and a puncture needle 23. After the capsule has been pushed into the puncture chamber 21 by the delivery mechanism, the capsule can be delivered from the side of the puncture chamber 21 close to the push rod 3 to the side close to the suction nozzle 5 by rotating the actuation knob 4. The actuation knob 4 pushes the capsule out of the puncture chamber 21 into the rotation chamber 6 through the lower end of the paddle 24 by the squeezing action of the paddle 24 on the actuation knob and the hollow shaft 25 connected to the housing 1. After rotating the actuation knob 4 to deliver the capsule to the side of the puncture chamber 21 close to the suction mouth 5, the actuation knob 4 is pressed so that, due to the action of the paddle 24 with the hollow shaft 25 located on the housing 1 (in particular, as shown in fig. 10), the paddle 24 will move to both sides, pushing the capsule out of the puncture chamber 21 into the rotation chamber 6, while the rotation chamber 6 is connected to the suction mouth 5. When the actuating knob 4 is released, the actuating knob 4 will spring upwards to its original position due to the action of the knob spring 20.

Optionally, the actuation knob 4 may be equipped with a second ratchet mechanism to ensure that the actuation knob 4 can only be rotated in one direction, thereby preventing malfunction during inhalation of the medicament.

Further, a slide cam 8 is located within the rotation chamber 6. When the puncture cavity 21 rotates in the rotating cavity 6, the puncture spring 22 and the puncture needle 23 are driven to rotate in the rotating cavity 6 together, so that the sliding cams 8 arranged on the upper side and the lower side of the inner wall of the rotating cavity 6 drive the puncture needle 23 to move up and down, and a capsule in the puncture cavity 21 is punctured.

In particular, fig. 6 illustrates the sliding cam 8 in more detail. As shown in fig. 6, the height variation of the puncture needle 23 in the rotary chamber 6 can be controlled by the height variation of the curved surface, so that when the puncture chamber 21 is rotated by the driving of the actuating knob 4, the capsule is punctured in the up-and-down movement of the puncture needle 23 and is simultaneously delivered to the side of the rotary chamber 6 near the mouthpiece 5.

Fig. 7 schematically illustrates an inhalation mechanism of a medicinal inhalation device according to an exemplary embodiment of the present invention. As shown in fig. 7, the suction nozzle 5 is connected to the rotary chamber 6 of the puncture mechanism by a pin 26.

Alternatively, as exemplarily shown in fig. 13, the bottom of the mouthpiece 5 may be provided with a grid portion limiting the movement of the capsule. The capsule will rotate in the rotation chamber when the medicine is inhaled so that the medicine can be sufficiently released, and the mesh portion will restrict the movement of the capsule, making the capsule rotate smoothly while ensuring that the medicine can be inhaled.

Fig. 8 schematically illustrates a delivery mechanism of a medicinal inhalation device according to another exemplary embodiment of the present invention. As shown in fig. 8, a capsule 35 containing a medicine is filled in a blister strip 34 having a special structure and being easily torn. After the blister strip 34 has been moved to a predetermined position, the rotating claw member 33 may pierce the blister strip 34 during its rotation and further deliver the capsule 35 to the side of the rotating chamber 32 close to the mouthpiece 31, thereby completing the delivery of the medicament-containing capsule.

In the embodiment shown in fig. 8, the use of the push rod is omitted, and therefore, the structure of the medicinal inhalation device can be further simplified, and the medicinal inhalation device can be made smaller and lighter.

Specifically, in the blister strip cooperating with the delivery mechanism shown in fig. 8, as shown in fig. 8, the slope of the side of each blister portion in contact with the rotating claw piece 33 is smaller than the opposite side of the blister portion, so that the capsules in the blister portion of the blister strip 34 are more easily taken out by the rotating claw piece 33.

When the user operates the medicine inhalation device according to the embodiment of the present invention, the user presses the push rod by opening the protective cover, and rotates the press knob to inhale the medicine. To prevent malfunction of the medicinal inhalation device, the blister strip is not delivered forward when the user opens and closes the protective cover multiple times. Only when the user opens the protective cover and presses the push rod, the user opens the protective cover again and the blister strip is delivered forward.

In another aspect, embodiments of the present invention provide a blister strip for use in any of the above-described medicinal inhalation devices. The blister strip includes at least one blister portion and a flexible portion configured to carry the at least one blister portion. Each blister portion contains a capsule of a single inhaled quantity of medicament. In particular, the blister strip comprises a blister portion and a flexible portion, for example made of PvC-type material on one side and of aluminium foil on the other side. Additionally, embodiments of the present invention provide that the blister strip can adaptively accommodate a variety of capsule sizes, including No. 5, No. 4, No. 3, No. 2, No. 1, No. 0, No. 00, No. 000, and the like. The purpose of the blister strip is to keep the capsules in an isolated environment, maintain a certain humidity, avoid light or other environmental factors that could potentially adversely affect the formulation, and condition the capsules prior to feeding them into the rotating chamber. For each dose to be delivered, the capsule to be used is moved by the prepared blister strip into the rotary chamber for use by the user. Once the user has emptied the formulation content of the capsule from the capsule, the mouthpiece can be opened to discard the empty capsule. By the drug inhalation device and the blister strip used therein provided by the embodiments of the present invention, compared with the prior art, it is possible to adopt a capsule filling technique to pre-meter the dosage of the drug in the capsule, and to use a certain number of capsules (e.g. 30 or 60) to construct a complete drug storage structure for sequential accurate delivery of multiple doses through a single drug storage structure. Combining multiple capsules together in a single drug storage structure enables the use of relatively inexpensive and mature capsule dosing techniques, thereby ensuring a validated dosing of the drug and protecting the drug from environmental factors such as temperature or humidity.

As will be appreciated by the person skilled in the art, the embodiments described above are only some of all embodiments of the invention, which is in no way limited to the example embodiments described above. On the contrary, many modifications and variations are possible within the scope of the appended claims. For example, other components may be added to or removed from the described apparatus. Other embodiments may be within the scope of the invention. Furthermore, in the claims, the word "comprising" does not exclude other elements or steps. The mere fact that certain measures are recited in mutually different dependent claims does not indicate that a combination of these measures cannot be used to advantage.

Claims

1. A medicinal inhalation device comprising a housing, and a transmission mechanism, a delivery mechanism, a piercing mechanism and an inhalation mechanism located within the housing, wherein

The housing is configured to receive a blister strip storing capsules;

the transmission mechanism is configured to transport capsules to be delivered in the blister strip to a predetermined position;

the delivery mechanism is configured to push out of the blister strip a capsule to be delivered in the blister strip from the predetermined position and deliver to a piercing mechanism;

the piercing mechanism is configured to pierce a capsule located within the piercing mechanism to enable medicament in the capsule to enter a human body through the inhalation mechanism upon inhalation by a user.

2. The medicinal inhalation device of claim 1, wherein said delivery mechanism comprises an advancing portion configured to advance a capsule in a blister portion located at said predetermined location to said piercing mechanism.

3. The medicinal inhalation device of claim 2, wherein the advancing means comprises a push rod configured to advance the capsule at the predetermined position in response to a depression and a push rod spring configured to reset the push rod in response to the depression being removed.

4. The medicinal inhalation device of claim 1, wherein the delivery mechanism comprises a rotating claw-shaped member configured to pierce the blister strip in response to being rotated and deliver the capsule to be delivered to the piercing mechanism by rotation.

5. The drug inhalation device of claim 1, wherein the transmission mechanism comprises a drive gear, a first driven gear, and a blister strip transfer wheel, the drive gear is configured to drive the first driven gear in rotation, and the blister strip transfer wheel is configured to transfer the blister strip under the drive of the first driven gear.

6. The medicinal inhalation device of claim 5, wherein the transmission mechanism further comprises a first ratchet mechanism configured to drive the drive gear in rotation.

7. The medicinal inhalation device of claim 6, further comprising a protective cover configured to cover the inhalation mechanism in a closed state and to actuate the first ratchet mechanism in an open state.

8. The drug inhalation device according to claim 5, wherein the transmission mechanism further comprises a second driven gear and a blister strip retraction wheel, the drive gear is further configured to rotate the second driven gear, and the blister strip retraction wheel is configured to retract the portion of the blister strip after the drug has been delivered, under the urging of the second driven gear.

9. The medicinal inhalation device of claim 1, wherein said piercing mechanism comprises a piercing chamber, an actuation knob, a paddle, a hollow shaft, a rotary chamber, a knob spring, a sliding cam, and a piercing needle, wherein said piercing chamber is connected to said transmission mechanism, configured to receive a capsule from said predetermined location;

the actuation knob is configured to deliver the capsule from a side of the puncture cavity proximate the advancing mechanism to a side proximate the inhaling mechanism in response to rotation and to deliver the capsule located within the puncture cavity to the rotation cavity through the paddle and the hollow shaft in response to depression,

the knob spring is configured to reset the actuation knob in response to the depression being removed,

the sliding cam is located within the rotating cavity and is configured to drive the piercing needle to pierce a capsule located within the piercing cavity.

10. The medicinal inhalation device of claim 9, wherein the actuation knob is equipped with a second ratchet mechanism configured to ensure unidirectional rotation of the actuation knob.

11. The medicinal inhalation device of claim 1, wherein said inhalation mechanism comprises a mouthpiece and a pin, said mouthpiece being connected to said piercing mechanism by said pin.

12. The medicinal inhalation device according to claim 11, wherein the mouthpiece is provided with a grid portion.

13. A blister strip for use in a medicinal inhalation device according to any of claims 1 to 12, wherein the blister strip comprises at least one blister portion and a soft portion configured to carry the at least one blister portion, each blister portion containing a single inhalation quantity of medicament in capsules, the blister strip being stored inside a housing.

14. Blister strip according to claim 13, for use in a medicinal inhalation device according to claim 4, and wherein the side of each blister portion in contact with the rotating claw member has a smaller slope than the opposite side of the blister portion.

15. The blister strip of claim 13, wherein the specifications of the capsules in the blister strip include size 5, 4, 3, 2, 1, 0, 00, 000.