CN211122891U - High-throughput automatic fluorescence immunoassay analyzer - Google Patents

Abstract

The utility model relates to a high flux automatic fluorescence immunoassay analyzer, which comprises a base for erecting a transverse translation unit; a plurality of adjustable sample seats matched with the heating unit are distributed on the edge of the front end of the base parallel to the transverse translation unit; the longitudinal translation unit is arranged corresponding to the adjustable sample seat, the longitudinal translation unit is matched with the sample withdrawing unit and the fluorescence detection unit, and the motion directions of the longitudinal translation unit and the transverse translation unit are vertical on the horizontal plane; an in-place detection unit is arranged on a base between any adjustable sample seat and the transverse translation unit; the transverse translation unit, the heating unit, the longitudinal translation unit, the sample withdrawing unit, the fluorescence detection unit and the in-place detection unit are connected to the controller. The utility model discloses with two sets of drives accomplish in succession not heating, detection and the appearance that moves back of unidimensional sample, the sample can be unordered gets into the sample seat, and all work are accomplished in horizontal translation unit coverage, complete machine simple structure, be convenient for adjust, the reliability is high, with low costs, occupation space is little, easy to maintain.

Description

High-throughput automatic fluorescence immunoassay analyzer

Technical Field

The utility model belongs to the technical field of utilize the optics means, utilize infrared light, visible light or ultraviolet ray to test or analysis material promptly, in particular to semi-automatic gold mark and the automatic fluorescence immunoassay appearance of high flux in fluorescence check out test set field.

Background

At present, the main immunochromatographic technology comprises fluorescence immunochromatography and colloidal gold chromatography, and the immunochromatographic rapid detection technology can be widely applied to field quantitative detection, is an important direction for the development of future instant detection technology, and is widely applied to the fields of drug detection of food, livestock raising and public security, biochemical detection of hospitals and the like.

Semi-automatic gold-labeled and fluorescence detection devices have been developed to increase the efficiency of mass detection. However, in the prior art, the semi-automatic gold mark and fluorescence detection device is mostly of a rotating disc type, and has the following defects:

(1) the mechanism is large and complex;

(2) the reliability is low, the cost is high, and the maintenance is inconvenient;

(3) the sample holder is not adjustable, and multiple sets of equipment may need to be prepared in order to adapt to samples with different widths, thicknesses and lengths;

(4) the sample output of the sample falls off by the dead weight and is easy to be blocked in the machine body, so that unnecessary disassembly or failure is caused.

SUMMERY OF THE UTILITY MODEL

The utility model provides an among the prior art, semi-automatic gold mark and fluorescence check out test set are the carousel formula more and the problem of a series of defects that lead to, provide the automatic fluorescence immunoassay appearance of high flux of an optimization structure.

The technical scheme adopted by the utility model is that the high-flux automatic fluorescence immunoassay analyzer comprises a base, wherein a transverse translation unit is arranged on the base; a plurality of adjustable sample seats are transversely distributed and arranged parallel to the edge of the front end of the base of the transverse translation unit; any adjustable sample seat is matched with a heating unit; a longitudinal translation unit matched with the transverse translation unit is arranged corresponding to the plurality of adjustable sample seats, the longitudinal translation unit is matched with the sample withdrawing unit and the fluorescence detection unit, and the movement directions of the longitudinal translation unit and the transverse translation unit are vertical on the horizontal plane; an in-place detection unit is arranged on a base between any adjustable sample seat and the transverse translation unit; the transverse translation unit, the heating unit, the longitudinal translation unit, the sample withdrawing unit, the fluorescence detection unit and the in-place detection unit are connected to the controller.

Preferably, the transverse translation unit comprises 2 support frames respectively arranged at two longitudinal ends of the base, a first screw rod parallel to the base is erected at the top of each of the 2 support frames, one end of the first screw rod is connected to the output end of the first motor, and a first nut is sleeved outside the first screw rod; the first nut is matched with the longitudinal translation unit.

Preferably, a first guide rail is arranged at the rear end of the support frame parallel to the first screw rod, the first nut is connected to a first sliding block through a first fixing plate, and the first sliding block is matched with the first guide rail; the first sliding block is matched with the longitudinal translation unit.

Preferably, the longitudinal translation unit comprises a second fixing plate which is matched with the transverse translation unit, a second motor is arranged at the rear end of the second fixing plate, the output end of the second motor is connected to a second screw rod, a second nut is sleeved outside the second screw rod, and the second nut is matched with the fluorescence detection unit and the sample withdrawing unit respectively; the second fixing plate is provided with a scanning unit connected to the controller in a matching way towards the front end.

Preferably, a second guide rail is arranged at the bottom of a second fixing plate parallel to the second screw, and the second nut is arranged in a matching manner with the second guide rail through a second sliding block.

Preferably, a fluorescence detection unit is arranged at the bottom of the second nut; the sample withdrawing unit comprises a third fixing plate arranged at the front end of the second nut, and a sample withdrawing rod is arranged at the bottom of the third fixing plate forwards; the distance between the horizontal projection of the sample stripping rod and the horizontal projection of the fluorescence detection unit is larger than 0.

Preferably, any one of the adjustable sample seats comprises a left seat and a right seat, and a heating unit is arranged between the left seat and the bottom plate and between the right seat and the bottom plate; and the top parts of the heating units corresponding to the left seat and the right seat are respectively provided with a transverse sliding chute.

Preferably, any one of the left seat and the right seat is provided with a plug-in buckle facing the front end of the bottom plate, and the plug-in buckle is matched with the sample.

Preferably, the in-place detection unit comprises an adjustable positioning plate, a plurality of positioning holes which are in one-to-one correspondence with the adjustable sample seats are formed in the rear end of the adjustable positioning plate, in-place sensors are arranged on the adjustable positioning plate behind the positioning holes in one-to-one correspondence with the positioning holes, a plurality of L-type contact pieces are arranged on the adjustable positioning plate in a matched mode, the rear portion of the L-type contact piece penetrates through the positioning holes, the rear end face of the L-type contact piece is attached to the in-place sensors, the top surface of the middle portion of the L-type contact piece is attached to the bottom surface of the adjustable positioning plate, and the front portion of the L-type contact piece is.

The utility model provides a high flux automatic fluorescence immunoassay appearance of optimized structure, through erect the horizontal translation unit that is on a parallel with a plurality of adjustable sample seats on the base, set up the heating element in adjustable sample seat bottom and be used for heating the sample and cultivate, the horizontal translation unit cooperation sets up the vertical translation unit, through the vertical translation unit drive move back the appearance unit and the fluorescence detection unit accomplishes the detection and the operation of moving back the appearance after the sample is cultivated, with the detection unit that targets in place guarantee each time the information feedback and the location after the sample seat is put into; the utility model discloses only can accomplish heating, detection and the back of a plurality of not unidimensional samples in succession with two sets of drives, the sample can be unordered gets into the sample seat.

The utility model discloses an adjustable sample holder can insert the sample of different width and thickness dimension, the detection mechanism that targets in place can make the sample of complete machine adaptation different length, and all works are accomplished at the within range that horizontal translation unit covered, and complete machine simple structure, be convenient for adjust, the reliability is high, with low costs, and occupation space is little, and easy to maintain is semi-automatic gold mark, fluorescence check out test set's ideal mechanism.

Drawings

Fig. 1 is a schematic structural view of a top view angle of the present invention;

fig. 2 is a schematic structural view of the present invention from the bottom;

fig. 3 is a schematic structural view of the heating unit and the adjustable sample holder of the present invention;

fig. 4 is a schematic structural view of the present invention with the first screw and the first nut omitted, showing the cooperation of the transverse translation unit and the longitudinal translation unit;

fig. 5 is a schematic structural view of the adjustable positioning plate with a middle upward viewing angle according to the present invention.

Detailed Description

The present invention will be described in further detail with reference to the following examples, but the scope of the present invention is not limited thereto.

The utility model relates to a high flux automatic fluorescence immunoassay analyzer, which comprises a base 1, wherein a transverse translation unit is erected on the base 1; a plurality of adjustable sample seats 2 are transversely distributed and arranged parallel to the edge of the front end of the base of the transverse translation unit; any one adjustable sample holder 2 is provided with a heating unit 3 in a matching way; a longitudinal translation unit matched with the transverse translation unit is arranged corresponding to the plurality of adjustable sample seats 2, the longitudinal translation unit is matched with a sample withdrawing unit and a fluorescence detection unit 4, and the movement directions of the longitudinal translation unit and the transverse translation unit are vertical on a horizontal plane; an in-place detection unit is arranged on a base between any adjustable sample holder 2 and the transverse translation unit; the transverse translation unit, the heating unit 3, the longitudinal translation unit, the sample withdrawing unit, the fluorescence detection unit 4 and the in-place detection unit are connected to the controller.

The utility model discloses in to base 1 wholly bears all functional parts on the analysis appearance, can accomplish the automatic fluorescence immunoassay of sample of a plurality of passageways with the area that occupies in a small amount of spaces of base 1 and front end.

The utility model discloses in, use adjustable sample seat 2 place end as "preceding", use adjustable sample seat 2 place end as horizontal limit, all positions thereafter use this as the benchmark.

In the utility model, the number of the adjustable sample seats 2 is multiple, and generally 6-8 adjustable sample seats can be arranged, so that the whole analyzer can be ensured to be rapidly circulated; the bottom of each adjustable sample holder 2 is provided with a heating unit 3 for heating the sample 27 and incubating the sample.

The utility model discloses in, the base 1 has erect the horizontal translation unit that is on a parallel with adjustable sample seat 2, particularly, horizontal translation unit transversely strides and establishes in base 1 middle part top for drive the lateral shifting of vertical translation unit.

The utility model discloses in to vertical translation unit drives the detection and the operation of withdrawing a specimen after sample 27 cultivates of withdrawing a specimen unit and fluorescence detecting element 4.

The utility model discloses in, the detecting element that targets in place ensures that the information feedback and the location after sample seat 2 puts into sample 27 each time, can be with the sample 27 of the different models of detecting element adaptation, size that targets in place simultaneously.

In the present invention, the controller can be set as a conventional control circuit and an integrated chip, which is a content easily understood by those skilled in the art, and those skilled in the art can set itself according to the requirement.

The utility model discloses in, obviously, can also integrate according to needs and be used for going on the reputation suggestion unit that targets in place suggestion, warning suggestion etc. and be used for carrying out the communication unit of network communication with other equipment, this content that technical staff in the field understood easily, technical staff in the field can set up by oneself according to the demand.

The utility model discloses only can accomplish in succession heating, detecting and withdrawing a kind of a plurality of not unidimensional samples 27 with two sets of drives, sample 27 can get into sample holder 2 unordered.

The utility model discloses an adjustable sample holder 2 can insert sample 27, the detection mechanism that targets in place of different width and thickness dimension can make the sample 27 of complete machine adaptation different length, and all works are accomplished at the within range that horizontal translation unit covered, and complete machine simple structure, be convenient for adjust, the reliability is high, with low costs, and occupation space is little, and easy to maintain is semi-automatic gold mark, fluorescence check out test set's ideal mechanism.

The transverse translation unit comprises 2 support frames 5 which are respectively arranged at the two longitudinal end parts of the base 1, a first screw 6 parallel to the base 1 is erected at the top of each support frame 5, one end of each first screw 6 is connected to the output end of a first motor 7, and a first nut 8 is sleeved outside each first screw 6; the first nut 8 is arranged in cooperation with the longitudinal translation unit.

A first guide rail 9 is arranged at the rear end of the support frame 5 parallel to the first screw 6, the first nut 8 is connected to a first sliding block 11 through a first fixing plate 10, and the first sliding block 11 is matched with the first guide rail 9; the first slide block 11 is matched with the longitudinal translation unit.

The utility model discloses in, the horizontal translation unit is whole to be heightened through 5 support frames, and both ends about base 1 are erect in support frame 5 setting, and first screw rod 6 has been erect at its top, and 6 one ends of first screw rod set up first motor 7, drive first screw rod 6 through the output of first motor 7 and rotate, and then drive the motion of the first nut 8 that 6 overcoat of first screw rod were established.

The utility model discloses in, through the control to first motor 7, can inject the position that first nut 8 is located for first screw rod 6, this is the conventional technique in this field, and the technical staff in this field can set up by oneself according to the demand.

The utility model discloses in, obviously, for the control of the convenient analysis appearance complete machine, first screw rod 6 is also parallel with a plurality of adjustable sample seats 2, and the mechanism unit that sets up under it promptly is towards the stroke of arbitrary corresponding adjustable sample seat 2 and equals.

In the utility model, the first nut 8 can be directly arranged with the longitudinal translation unit integrally and drive the longitudinal translation unit to move; in fact, in order to ensure the overall operation stability of the mechanism, a first guide rail 9 may be disposed at the rear end of the supporting frame 5 parallel to the first screw 6, the first nut 8 is connected to the first slider 11 through a first fixing plate 10, and the longitudinal translation unit under the first slider 11 is driven to move through the cooperation between the first slider 11 and the first guide rail 9.

The utility model discloses in, in order to guarantee first slider 11 and first guide rail 9's cooperation, generally set up first slider 11 to built-in have spout, first guide rail 9 to run through the structure of spout.

The utility model discloses in, generally speaking, in order to further guarantee the operation effect, first fixed plate 10 and first slider 11 can set up by integration.

The longitudinal translation unit comprises a second fixing plate 12 matched with the transverse translation unit, a second motor 13 is arranged at the rear end of the second fixing plate 12, the output end of the second motor 13 is connected to a second screw 14, a second nut 15 is sleeved outside the second screw 14, and the second nut 15 is matched with the fluorescence detection unit 4 and the sample withdrawing unit respectively; the second fixing plate 12 is provided with a scanner unit 26 toward the front end thereof to be connected to a controller.

A second guide rail 16 is arranged at the bottom of the second fixing plate 12 parallel to the second screw 14, and the second nut 15 is arranged in a matching way with the second guide rail 16 through a second sliding block 17.

The bottom of the second nut 15 is provided with a fluorescence detection unit 4; the sample withdrawing unit comprises a third fixing plate 18 arranged at the front end of the second nut 15, and a sample withdrawing rod 19 is arranged at the bottom of the third fixing plate 18 forwards; the distance between the horizontal projection of the sample withdrawal rod 19 and the horizontal projection of the fluorescence detection unit 4 is greater than 0.

The utility model discloses in, vertical translation unit is including the second fixed plate 12 that the horizontal translation unit of cooperation set up, and the purpose of second fixed plate 12 is mainly in order to be connected with horizontal translation unit, particularly, for being connected with the bottom of first slider 11, of course, also can set up second fixed plate 12 and the integration of first fixed plate 10, add intensity.

The utility model discloses in, set up second motor 13 in the rear end of second fixed plate 12 to the output of second motor 13 drives the motion of second screw rod 14, and then drives the back-and-forth movement of second nut 15.

The utility model discloses in, the bottom of second nut 15 sets up fluorescence detecting element 4, and fluorescence detecting element 4 is the conventional technology in this field, and it generally is fluorescence immunoassay reagent card detection mechanism, and technical personnel in the field can purchase the setting according to the demand, if with the built-in module of the series product of the science and technology etc. also can assemble by oneself according to the demand.

The utility model discloses in, scanning unit 26 has the function of scanning reading code, can scan the code 28 on the reagent card and then acquire the relevant information about inspection item, reagent batch and incubation time, the management of being convenient for. The position of the positioning device can be adjusted, and the positioning device can be fixed by arranging a support arm plate extending from the second fixing plate 12, and the position of the adjustable positioning plate 21 relative to the base 1 can be changed to correspond and read codes 28 on the scanning unit 26 and the sample 27. As is conventional, one skilled in the art can purchase and set up the scanning unit 26 as needed, or can assemble the scanning unit as needed.

The utility model discloses in, the code 28 of setting on sample 27 can satisfy the demand for one-dimensional code.

The utility model discloses in, the front end of second nut 15 is provided with third fixed plate 18, and the bottom of third fixed plate 18 sets up forward and moves back a kind pole 19, moves back the height scope coincidence behind the height and the general sample 27 of a kind pole 19 place on adjustable sample seat 2, and it can act on sample 27 male tip promptly to through the removal of second nut 15, borrow by moving back a kind pole 19 and release sample 27.

The utility model discloses in, in order to guarantee that the operation between the unit of withdrawing a specimen and fluorescence detecting element 4 does not have the interact, the event is withdrawn a specimen rod 19 the horizontal projection and fluorescence detecting element 4 the horizontal projection between the distance be greater than 0, generally speaking, fluorescence detecting element 4 sets up under second nut 15, and the side the place ahead of second nut 15 is then located relatively to the pole of withdrawing a specimen 19, under this condition, only need horizontal translation unit to remove a segment distance, can be so that second nut 15 drives the operation that the unit of withdrawing a specimen or fluorescence detecting element 4 accomplished the difference.

The utility model discloses in, be different from traditional large-scale mechanism of withdrawing a specimen, through ingenious utilization complete machine structure, carry on with low costs, reliable, simple pole 19 that withdraws a specimen, reach the complete machine small and exquisite, reliable, purpose with low costs.

The utility model discloses in, for guaranteeing that the holistic function of mechanism is stable, can set up second guide rail 16 in the second fixed plate 12 bottom that is on a parallel with second screw rod 14, second nut 15 carries out more stable removal through the cooperation between second slider 17 and second guide rail 16.

The utility model discloses in, in order to guarantee second slider 17 and second guide rail 16's cooperation, generally set up second slider 17 to built-in have spout, second guide rail 16 to run through the structure of spout.

The utility model discloses in, second nut 15 and second slider 17 can also the integration setting, reduce the fastening operation.

Any adjustable sample holder 2 comprises a left holder and a right holder, and a heating unit 3 is arranged between the left holder and the bottom plate 1 and between the right holder and the bottom plate 1; the top of the heating unit 3 corresponding to the left seat and the right seat is respectively provided with a transverse sliding chute 29.

And a plug-in buckle 20 facing the front end of the bottom plate 1 is arranged on any one of the left seat and the right seat, and the plug-in buckle 20 is matched with the sample 27.

The utility model discloses in, in order to reach the high purpose of sample 27 adaptation degree, adjustable sample seat 2 sets up to the form of left seat and right seat, and left seat and right seat can remove about in horizontal spout 29, reach chucking sample 27's purpose.

The utility model discloses in, adjustable sample holder 2 can adapt to the sample 27 of different width and thickness, and simple structure is reliable, and is with low costs.

The utility model discloses in, set up heating element 3 between left seat and right seat and bottom plate 1, generally speaking, heating element 3 is with the whole complex heating panel of adjustable sample seat 2, and its control that can the controller reaches the purpose of hatching with constant temperature.

The utility model discloses in, for the adaptation between adjustable sample seat 2 of better assurance and sample 27, can set up the eye-splice 20 towards bottom plate 1 front end on every adjustable sample seat 2, the eye-splice 20 can be inserted with the jack of sample 27 bottom etc. promptly and close, guarantees that sample 27 is located correct position and remain stable at whole incubation, the in-process that detects.

The utility model discloses in, eye-splice 20 can set up simultaneously on the left seat and the right seat of every adjustable sample seat 2, also can only set up one of left seat and right seat.

The in-place detection unit comprises an adjustable positioning plate 21, a plurality of positioning holes 23 which correspond to the adjustable sample seats 2 one by one are formed in the rear end of the adjustable positioning plate 21, in-place sensors 22 are arranged on the adjustable positioning plate 21 behind the positioning holes 23 and correspond to the positioning holes 23 one by one, a plurality of L-type contact pieces 24 are arranged in a matched mode on the adjustable positioning plate 21, the rear portion of the L-type contact piece 24 penetrates through the positioning holes 23, the rear end face of the L-type contact piece 24 is attached to the in-place sensors 22, the top face of the middle portion of the L-type contact piece 24 is attached to the bottom face of the adjustable positioning plate 21, and the front portion of the L-type contact piece 24 is attached to the.

The utility model discloses in, because the specification of sample 27 is different, then its degree of pushing of different sample 27 may be uncontrollable, so need set up the detecting element that targets in place, its sample 27 that can adapt to different length, the mechanism is adjusted simply, reliably, with low costs.

The utility model discloses in, through L type contact piece 24 preceding terminal surface and rear end face transmission contact signal, when L type contact piece 24 preceding terminal surface runs into male sample 27, and then the rear end face of L type contact piece 24 that runs through the locating hole 23 setting obtains the signal, triggers the operation of sensor 22 that targets in place.

In the present invention, the sensor 22 can be a micro-switch under normal conditions.

In the utility model, based on the fact that the sample 27 may be very short, the in-place detection unit is provided with not only the in-place sensor 22 for helping the sample 27 to be detected in place, but also the adjustable positioning plate 21, i.e. the distance between the positioning plate 21 and the adjustable sample holder 2 can be different to adapt to different samples 27; generally, the distance between the adjustable positioning plate 21 and the in-place sensor 22 is adjusted by adjusting the relative position between the adjustable positioning plate 21 and the base 1, for example, a long hole 25 is provided on the base 1, and a sliding rod is provided at the bottom of the adjustable positioning plate 21 in cooperation with the long hole 25.

The control method of the high-throughput automatic fluorescence immunoassay analyzer comprises the following steps.

Step 1: installing an in-place detection unit, aligning the correspondingly arranged in-place sensors 22 with the adjustable sample seats 2 one by one, and finishing positioning; initializing the analyzer, and setting the current working temperature of the heating unit 3;

step 2: the first motor 7 and the second motor 13 work to respectively drive the first nut 8 and the second nut 15 to return to the end parts of the first screw 6 and the second screw 14 close to the first motor 7 and the second motor 13.

In the present invention, in general, the end portions of the first screw rod 6 and the second screw rod 14 close to the first motor 7 and the second motor 13 are the initial positions of the first nut 8 and the second nut 15 by default.

The utility model discloses in, first motor 7 and second motor 13 can set up to step motor, also can be ordinary motor certainly, and the rotation through the control motor controls first nut 8 and the 15 motion of second nut to predetermined position.

The utility model discloses in, to first nut 8, the position of first nut 8 when predetermined position includes the axis position of every adjustable sample seat 2 and aims at the axis of every adjustable sample seat 2 with the pole 19 that takes a back of a theatrical performance as a contrast.

In the present invention, for the second nut 15, the maximum stroke is the detection position from the initial position to the sample 27 closest to the edge of the base 1 of the fluorescence detection unit 4.

In the present invention, since the temperature requirement of the same batch of samples 27 is generally the same, the same batch of samples 27 can be placed on any one of the sample holders 2 at any time during the test, but the working temperatures of all the samples 27 are actually equal, so that the working temperature of the heating unit 3 can be set during the initialization process.

And step 3: placing a sample 27 on any adjustable sample holder 2, adjusting the adjustable sample holder 2 until the bottom of the sample 27 is buckled with the buckle 20 and the in-place sensor 22 detects that the sample 27 is in place; the controller controls the heating unit 3 at the bottom of the current adjustable sample holder 2 to start heating, and the controller times.

And 4, step 4: the first motor 7 works, the first nut 8 and the first screw 6 are matched and reach the front of the currently placed sample 27 to be cultivated; the controller controls the scanning unit 26 to scan the sample 27, and the scanning unit 26 transmits the scanning data to the controller to generate the incubation time of the current sample 27.

And 5: if the incubation time of any sample 27 reaches the standard value, the next step is carried out, otherwise, whether any in-place sensor 22 detects that the sample 27 is in place is judged; if so, starting heating timing for the sample seat 2 with the new sample 27 in place, returning to the step 4, otherwise, repeating the step 5;

the utility model discloses in, step 3 to step 5 have satisfied that sample 27 can be placed in adjustable sample seat 2 by unordered, confirm the beginning of timing through the sensor 22 that targets in place, through the controller to the control of time, carry out subsequent operation automatically after reacing incubation time.

The utility model discloses in, particularly, set up the constant temperature from the start, heating element 3 begins the heating promptly, and follow-up sample 27 of putting but not yet by scanning information also just begins the heating to cultivate putting, and the time spent will count into total incubation time.

The utility model discloses in, after sample 27 placed on sample holder 2, first motor 7 began work promptly, fixes a position sample 27 on the horizontal plane, acquires scan data with scanning unit 26 simultaneously, if can obtain specific incubation time of cultivating through the code 28 on the scanning sample 27.

The utility model discloses in, for the convenience of management, in actual operation, the controller is obtaining new cultivation incubation time after, can carry out from little to big sequencing with the cultivation incubation time of all records according to the time left, guarantees to accomplish the sample 27 that cultivates recently and accomplishes the cultivation back, can carry out fluorescence detection and release the very first time.

Step 6: the first motor 7 works, the first nut 8 is matched with the first screw 6 and reaches the front of the sample 27 which is completely cultivated; the first motor 7 stops operating.

The utility model discloses in, the position of first nut 8 is the axis position of the adjustable sample seat 2 that the sample 27 place of accomplishing the cultivation for aiming at this moment.

And 7: the second motor 13 works, the second nut 15 is matched with the second screw 14, the second nut 15 drives the fluorescence detection unit 4 to scan outwards from the insertion end of the sample 27 and return, and the fluorescence detection unit 4 transmits detection data to the controller.

And 8: the first motor 7 works, the first nut 8 and the first screw 6 move in a matching way until the sample withdrawing rod 19 is opposite to the insertion end of the current sample 27; the first motor 7 stops working; if the incubation time for any other sample 27 is up to the standard value, return to step 6, otherwise, proceed to the next step.

The utility model discloses in, after having carried out the fluorescence detection of last sample 27, when having the fluorescence detection demand of next sample 27 at once, the operation of moving back a kind is not gone on temporarily, but at first detects next sample 27 that need carry out fluorescence detection, has guaranteed the accuracy nature that detects.

The utility model discloses in, first nut 8's when the position of first nut 8 during step 8 is the axis that the pole 19 that moves back aimed at every adjustable sample seat 2 position of first nut.

And step 9: the second motor 13 works, the second nut 15 is matched with the second screw 14, the second nut 15 drives the sample withdrawing rod 19 to move forwards, and the sample withdrawing rod 19 pushes out the sample 27.

Step 10: the controller analyzes the detection data; return to step 5 or shut down.

In the utility model, the controller can analyze the detection data automatically, and also can transmit the data to the PC end, and the data is analyzed by a more precise instrument; this process does not interfere with the normal operation of steps 3 through 9.

The utility model discloses a set up the horizontal translation unit that is on a parallel with a plurality of adjustable sample seats 2 on base 1, set up heating element 3 and be used for heating sample 27 and cultivate in adjustable sample seat 2 bottoms, horizontal translation unit cooperation sets up the vertical translation unit, through the vertical translation unit drive move back the appearance unit and fluorescence detection unit 4 accomplish sample 27 detection and move back the appearance operation after cultivating, with the detection unit that targets in place ensure each time the information feedback and the location after sample seat 2 puts into; the utility model discloses only can accomplish in succession heating, detecting and withdrawing a kind of a plurality of not unidimensional samples 27 with two sets of drives, sample 27 can get into sample holder 2 unordered.

The utility model discloses an adjustable sample holder 2 can insert sample 27, the detection mechanism that targets in place of different width and thickness dimension can make the sample 27 of complete machine adaptation different length, and all works are accomplished at the within range that horizontal translation unit covered, and complete machine simple structure, be convenient for adjust, the reliability is high, with low costs, and occupation space is little, and easy to maintain is semi-automatic gold mark, fluorescence check out test set's ideal mechanism.

Claims (9)

1. A high-throughput automatic fluorescence immunoassay appearance, includes the base, its characterized in that: a transverse translation unit is erected on the base; a plurality of adjustable sample seats are transversely distributed and arranged parallel to the edge of the front end of the base of the transverse translation unit; any adjustable sample seat is matched with a heating unit; a longitudinal translation unit matched with the transverse translation unit is arranged corresponding to the plurality of adjustable sample seats, the longitudinal translation unit is matched with the sample withdrawing unit and the fluorescence detection unit, and the movement directions of the longitudinal translation unit and the transverse translation unit are vertical on the horizontal plane; an in-place detection unit is arranged on a base between any adjustable sample seat and the transverse translation unit; the transverse translation unit, the heating unit, the longitudinal translation unit, the sample withdrawing unit, the fluorescence detection unit and the in-place detection unit are connected to the controller.

2. The high throughput automated fluoroimmunoassay analyzer of claim 1, wherein: the transverse translation unit comprises 2 support frames which are respectively arranged at the longitudinal two end parts of the base, a first screw rod parallel to the base is erected at the top of each support frame 2, one end of the first screw rod is connected to the output end of the first motor, and a first nut is sleeved outside the first screw rod; the first nut is matched with the longitudinal translation unit.

3. The high throughput automated fluoroimmunoassay analyzer of claim 2, wherein: a first guide rail is arranged at the rear end of the support frame parallel to the first screw rod, the first nut is connected to a first sliding block through a first fixing plate, and the first sliding block is matched with the first guide rail; the first sliding block is matched with the longitudinal translation unit.

4. The high throughput automated fluoroimmunoassay analyzer of claim 1, wherein: the longitudinal translation unit comprises a second fixing plate matched with the transverse translation unit, a second motor is arranged at the rear end of the second fixing plate, the output end of the second motor is connected to a second screw rod, a second nut is sleeved outside the second screw rod, and the second nut is matched with the fluorescence detection unit and the sample withdrawing unit respectively; the second fixing plate is provided with a scanning unit connected to the controller in a matching way towards the front end.

5. The high throughput automated fluoroimmunoassay analyzer of claim 4, wherein: and a second guide rail is arranged at the bottom of a second fixing plate parallel to the second screw rod, and the second nut is matched with the second guide rail through a second sliding block.

6. The high throughput automated fluoroimmunoassay analyzer of claim 4, wherein: a fluorescence detection unit is arranged at the bottom of the second nut; the sample withdrawing unit comprises a third fixing plate arranged at the front end of the second nut, and a sample withdrawing rod is arranged at the bottom of the third fixing plate forwards; the distance between the horizontal projection of the sample stripping rod and the horizontal projection of the fluorescence detection unit is larger than 0.

7. The high throughput automated fluoroimmunoassay analyzer of claim 1, wherein: any adjustable sample seat comprises a left seat and a right seat, and a heating unit is arranged between the left seat and the bottom plate and between the right seat and the bottom plate; and the top parts of the heating units corresponding to the left seat and the right seat are respectively provided with a transverse sliding chute.

8. The high throughput automated fluoroimmunoassay analyzer of claim 7, wherein: and a plug-in buckle facing the front end of the bottom plate is arranged on any one of the left seat and the right seat and is matched with the sample.

9. The high-throughput automatic fluoroimmunoassay analyzer according to claim 1, wherein the in-place detection unit comprises an adjustable positioning plate, a plurality of positioning holes corresponding to the adjustable sample holders are arranged at the rear end of the adjustable positioning plate, in-place sensors are arranged on the adjustable positioning plate behind the positioning holes in a one-to-one correspondence with the positioning holes, a plurality of L-type contact pieces are arranged on the adjustable positioning plate in a matching manner, the rear portion of the L-type contact piece penetrates through the positioning holes, the rear end face of the L-type contact piece is attached to the in-place sensors, the top surface of the middle portion of the L-type contact piece is attached to the bottom surface of the adjustable positioning plate, and the front portion of the L-type contact piece is attached to the front end face of the adjustable positioning plate and corresponds.

Images