CN211068689U

CN211068689U - Administration tube, administration device, and neuropsychiatric disease treatment system

Info

Publication number: CN211068689U
Application number: CN201921314556.2U
Authority: CN
Inventors: 王璐璐; 鲁艺; 钟成; 曹燚; 潘苏婉; 王立平
Original assignee: Shenzhen Institute of Advanced Technology of CAS
Current assignee: Shenzhen Institute of Advanced Technology of CAS
Priority date: 2019-08-14
Filing date: 2019-08-14
Publication date: 2020-07-24
Anticipated expiration: 2029-08-14
Also published as: WO2021027192A1

Abstract

The utility model provides a medicine feeding pipe, a medicine feeding device and a neuropsychiatric disease treatment system, which relate to the technical fields of medical instruments, neuroscience and the like. An administration tube comprises a first tube body and a second tube body which are mutually and hermetically connected; the first tube is used for being implanted into the brain area, the outer diameter range of the first tube is 350-; the second body is used for being connected with a medicine feeding device, the hardness of the second body is smaller than that of the first body, the inner diameter of the second body is not smaller than the outer diameter of the first body, the technical problem that an existing medicine feeding pipe is large in size and inconvenient to use is solved, and the technical effects of convenience in use, simple structure and wide application range are achieved.

Description

Administration tube, administration device, and neuropsychiatric disease treatment system

Technical Field

The utility model relates to the technical field of medical apparatus, neuroscience and the like, in particular to a drug delivery tube, a drug delivery device and a neuropsychiatric disease treatment system.

Background

In recent years, brain science has rapidly developed, wherein the research on neuropsychiatric diseases is more towards the heat fire, however, the problem which is the most complex and difficult to solve in human beings still exists. Therefore, scientists hope to research the pathogenesis of neuropsychiatric diseases such as epilepsy, depression and schizophrenia, and further discuss more effective clinical treatment targets and parameters. However, in the research process, one of the biggest difficulties is to develop new research technology and research method to help neuroscientists to draw clearer maps of brain circuits, so that the functions of the brain are more comprehensively and deeply understood, and the precise regulation and control of the cranial nerve activity under high spatial and temporal resolution is realized. Finally, the utility model helps people to understand the processing mechanism of the brain's functions such as cognition, emotion and memory, and paves the way for the treatment of neuropsychiatric diseases.

In the field of neuroscience, generally, optogenetics and pharmacogenetics are used to achieve the regulation of specific cell types in specific brain regions. In pharmacogenetics, it is necessary to inject viruses specifically expressed on specific types of neurons into the brains of experimental animals in advance. After four weeks of expression, the drug delivery tube is implanted above the brain area of the experimental animal research, and the micro-injection pump is used for injecting the drug into the brain, so that the specific regulation and control of the brain area are realized.

Currently, many companies already have finished administration tubes which require a small cap to be attached after implantation, the size of the entire small cap being large, and the finished administration tube is completely satisfactory if administration is required only in a specific brain area. However, if one wants to administer drugs to a plurality of brain regions simultaneously or combine light stimulation or electrophysiological recording, it is inconvenient because the size of the administration tube is large, two or more administration tubes cannot be implanted simultaneously, the administration tube cannot combine optical fibers to perform the administration and light stimulation processes simultaneously, the administration tube cannot combine different types of electrodes to perform the administration and electrophysiological recording processes simultaneously, and the like.

SUMMERY OF THE UTILITY MODEL

An object of the utility model is to provide a administer pipe, device and neuropsychiatric disease treatment system of dosing to alleviate above-mentioned at least one problem.

The utility model provides a medicine feeding tube, include: the first pipe body and the second pipe body are hermetically connected with each other;

the first tube is used for being implanted into the brain area, the outer diameter range of the first tube is 350-;

the second tube body is used for being connected with a medicine feeding device, the hardness of the second tube body is smaller than that of the first tube body, and the inner diameter of the second tube body is not smaller than the outer diameter of the first tube body.

Further, the outer diameter of the second tube is 900-.

Further, the outer diameter of the first pipe body is 356 microns, and the inner diameter of the first pipe body is 182 microns;

and/or the outer diameter of the second pipe body is 1000 microns, and the inner diameter of the second pipe body is 500 microns.

Furthermore, one end of the first pipe body can be inserted into the second pipe body, and the depth of the first pipe body inserted into the second pipe body is 5 mm.

Furthermore, the first pipe body is connected with the second pipe body through a sealant.

Further, the intercepting length size of the first pipe body is 1cm larger than the depth size of the brain implantation area;

and/or the cut length of the second pipe body is 3 cm.

Further, the first pipe body is a silicon pipe, a glass pipe or a polymer pipe, and is preferably a silicon pipe;

and/or the second pipe body is a plastic pipe or a rubber pipe, preferably a rubber pipe.

Further, the medicine feeding device at least comprises an injector, and the output end of the injector is connected with the end, far away from the first tube, of the second tube.

The utility model provides a drug delivery device, include the drug delivery tube.

The utility model provides a neuropsychiatric disease treatment system, which comprises a drug delivery device;

alternatively, an electrophysiological recording device and an administration device are included;

alternatively, a light stimulation device and a drug delivery device are included;

or an electrophysiological recording device, a light stimulation device and a drug delivery device.

The utility model provides a pair of medicine feeding tube has following advantage:

in the utility model, the first tube body is used for being implanted into the brain region, because the size is smaller, the outer diameter range is only 350-fold 360 μm, the inner diameter range is only 180-fold 190 μm, the administration tube implanted into the brain region is thin, and therefore, the injury to the brain tissue after implantation is very small.

Preferably, the second tube is located outside the brain, the inner diameter of the second tube is not smaller than the outer diameter of the first tube, and the first tube needs to be connected with the second tube, so that the difference between the inner diameter of the second tube and the outer diameter of the first tube is not too large, and the sealing connection between the second tube and the first tube is ensured; in addition, because the pipe wall of second body can not be too thick for second body external diameter also can be less relatively, from this, the utility model provides a can implant a plurality of brain areas simultaneously for the pipe, satisfy the requirement of dosing for a plurality of brain areas simultaneously.

Preferably, the administration tube only comprises the first tube body and the second tube body which are hermetically connected with each other, so that the administration tube is simple in overall structure and low in cost, and is convenient to operate due to simple structure in the using process.

The utility model provides a pair of device of dosing, including the above-mentioned pipe of dosing, from this, the technical advantage that the device of dosing reached includes the above-mentioned technical advantage that reaches of dosing pipe, and the here is no longer repeated.

The utility model provides a pair of neuropsychiatric disease treatment system, including the above-mentioned device of dosing, certainly, can also include at least one kind among electrophysiological recording device and the light stimulation device, from this, except including the above-mentioned technical advantage that the device of dosing reaches, can also combine optic fibre to carry out the light stimulation or combine different kind of electrode to carry out electrophysiological recording, combine to carry out light stimulation and electrophysiological recording even simultaneously, make the range of application wider.

Drawings

In order to more clearly illustrate the embodiments of the present invention or the technical solutions in the prior art, the drawings used in the embodiments or the technical solutions in the prior art will be briefly described below, and it is obvious that the drawings in the following description are some embodiments of the present invention, and for those skilled in the art, other drawings can be obtained according to these drawings without creative efforts.

Fig. 1 is a schematic structural view of an administration tube according to an embodiment of the present invention.

Icon: 100-a first tube; 200-a second tube.

Detailed Description

The technical solution of the present invention will be described clearly and completely with reference to the following embodiments, and it should be understood that the described embodiments are some, but not all embodiments of the present invention. Based on the embodiments in the present invention, all other embodiments obtained by a person skilled in the art without creative work belong to the protection scope of the present invention.

Example one

The embodiment provides an administration tube, which comprises a first tube body 100 and a second tube body 200 which are hermetically connected with each other;

the first tube 100 is used for being implanted into the brain region, the outer diameter of the first tube 100 ranges from 350-;

the second tube 200 is used for connecting with a drug delivery device, the hardness of the second tube 200 is less than that of the first tube 100, and the inner diameter of the second tube 200 is not less than the outer diameter of the first tube 100.

Specifically, the administration tube in this embodiment includes the first tube 100 and the second tube 200 that are connected to each other, and in the use, the first tube 100 is implanted to a section in the brain area to leave a section and expose outside the brain, because the external diameter size of the first tube 100 is smaller, very conveniently implant in the brain area, and the section that exposes outside the brain is very conveniently fixed again.

The second tube 200 is completely exposed to the outside of the brain, and an end of the second tube 200 not connected to the first tube 100 is coupled to a small amount of the drug delivery device, so that the drug can be injected into the brain region through the drug delivery device via the second catheter and the first catheter in sequence.

It should be noted that, the first tube body 100 and the second tube body 200 both adopt a tubule structure, and the two tubules can also adopt the existing finished product, or directly purchase, or adopt the customization, and the experimental personnel need to design according to own experimental requirements for the specific situation can.

The embodiment also provides a manufacturing step and a method of the administration tube, which specifically comprise the following steps:

intercepting a certain length of the first tube body 100 and intercepting a certain length of the second tube body 200 according to actual needs, then connecting the first tube body 100 with one end of the second tube body 200, and enabling the sealing between the first tube body and the second tube body to be good, and the other end of the second tube body 200 is used for being combined with a medicine feeding device, so that the manufacturing of the medicine feeding tube and the combination of the medicine feeding tube and the medicine feeding device are completed.

The administration tube provided by the embodiment has the following advantages:

because the first tube 100 has a small size, the outer diameter ranges from 350-.

Moreover, the second tube 200 is located outside the brain, the inner diameter of the second tube is not smaller than the outer diameter of the first tube 100, and the first tube 100 needs to be connected with the second tube 200, so that the difference between the inner diameter of the second tube 200 and the outer diameter of the first tube 100 is not too large, and the sealing connection between the two is ensured; in addition, because the pipe wall of second body 200 can not be too thick for second body 200 external diameter also can be less relatively, from this, the utility model provides an it can implant a plurality of brain areas simultaneously to administer the pipe, satisfies the requirement of dosing for a plurality of brain areas simultaneously.

In addition, the administration tube provided by the embodiment only comprises the first tube body 100 and the second tube body 200 which are connected with each other, so that the whole structure of the administration tube is simple, the cost is low, and in the using process, the operation is also convenient due to the simple structure.

In an optional technical solution of this embodiment, the outer diameter of the second tube 200 ranges from 900-.

Further preferably, the outer diameter of the first pipe 100 is 356 μm, and the inner diameter is 182 μm; and/or the second tube 200 has an outer diameter of 1000 μm and an inner diameter of 500 μm.

It should be noted that, based on the specific dimensions of the first tube 100 and the second tube 200, compared to the prior art in which a small cap is required to be fastened after the administration tube is implanted, and the size of the whole small cap is larger, the diameter of the administration tube in this embodiment is greatly reduced, so that the injury to the brain tissue caused by the implantation into the brain area can be reduced, and simultaneously, the administration to a plurality of brain areas, or the combination of optical stimulation and electrophysiological recording can be conveniently performed.

In the optional technical scheme of this embodiment, one end of the first pipe 100 can be inserted into the second pipe 200, and the distance that the first pipe 100 is inserted into the second pipe 200 is 5 mm.

In an optional technical solution of this embodiment, the first pipe 100 is connected to the second pipe 200 by a sealant.

In this embodiment, the connection mode of the first tube 100 and the second tube 200 is as follows:

since the inner diameter of the second pipe 200 is not smaller than the outer diameter of the first pipe 100, the first pipe 100 can be inserted into the second pipe 200. When the difference between the inner diameter of the second tube 200 and the outer diameter of the first tube 100 is large, the gap between the two will be large after insertion, which will affect the accuracy of the injection amount of the medicine at the later stage; that is, the first tube 100 and the second tube 200 must be sealed without any gap, so that a minute amount of medicine cannot be accurately injected at a later stage.

In view of the above problems, in the present embodiment, it is necessary to seal the gap between the first tube 100 and the second tube 200, preferably, a small amount of 502 is used to fix the two together, and after the 502 is dried, the gap is sealed by using the sealant, and here, preferably, the absolute double-glue sealing is used.

Further preferably, the size of the first tube 100 inserted into the second tube 200 is 5mm, and then the gap between the two is sealed by the sealing compound, so as to ensure that the connection between the two is firmer and good sealing performance is ensured.

In the optional technical solution of this embodiment, the intercepted length of the first tube 100 is 1cm greater than the depth of the brain implantation area;

and/or the second tube 200 may have a cut length of 3 cm.

In this embodiment, the first tube 100 and the second tube 200 are cut out according to actual conditions when manufacturing the administration tube, and considering that the first tube 100 needs to be inserted into the second tube 200 by 5mm and needs to fall on the outside of the brain for convenient implantation and fixation, the first tube 100 in this embodiment can be divided into a brain implantation section, a second tube 200 insertion section and an outside of the brain exposure section. Preferably, the length of the exposed portion of the brain is 5mm, so that the first tube 100 needs to be cut out to a length 1cm longer than the implanted brain region.

In an optional technical solution of this embodiment, the first tube 100 is a silicon tube, a glass tube, or a polymer tube, preferably a silicon tube;

and/or the second tube 200 is a plastic or rubber tube, preferably a rubber tube.

It should be noted that, in order to implant one end of the first tube 100 into the brain region, the first tube 100 needs to have a certain hardness, and thus, the first tube 100 in this embodiment is made of a material with a relatively high hardness, such as a silicon tube, a glass tube, a polymer tube, and the like, so as to facilitate the implantation of the first tube 100 into the brain region without deformation. In this embodiment, a silicon tube is preferably used to ensure that the first tube 100 has sufficient hardness and is not easily deformed when being implanted into the brain region.

In addition, since the second tube 200 is exposed outside the brain, it is not necessary to implant the second tube into the brain region, and it is necessary to connect the first tube 100 and the drug delivery device, therefore, the second tube 200 can be made of a softer material, such as a plastic tube, a rubber tube, etc., and in this embodiment, a rubber tube is preferably used to facilitate the connection with the drug delivery device and the connection with the first tube 100.

In the optional technical scheme of this embodiment, the medicine is sent into the device and is included the syringe at least, and the output of syringe is used for keeping away from the end connection of first body 100 with second body 200, from this, can pass through second body 200, first body 100 injection brain district in proper order with the liquid medicine through the syringe, realizes the action of dosing to brain district.

Example two

This embodiment provides a drug delivery device comprising the drug delivery tube of the first embodiment, whereby the technical advantages achieved by the drug delivery device include the technical advantages achieved by the drug delivery tube described above, which are not described in detail herein.

EXAMPLE III

The embodiment provides a neuropsychiatric disease treatment system, which comprises the drug delivery device in the second embodiment;

or include electrophysiological recording device and administration device, or include photostimulation device and administration device, or include electrophysiological recording device, photostimulation device and administration device, therefore, besides including the technical advantage that the above-mentioned administration device reaches, can also combine the optic fibre to carry out photostimulation or combine different kinds of electrodes to carry out electrophysiological recording, even combine carrying out photostimulation and electrophysiological recording at the same time, make the range of application wider.

It should be noted that, with regard to the process or principle of the electrophysiological experiment implemented by the electrophysiological recording device, and the administration behavior implemented by the administration tube or the administration device in combination with different kinds of electrodes, reference can be made to the prior art, and details thereof are not described herein.

In addition, reference may be made to the prior art regarding the process or principle of the optical stimulation experiment implemented by the optical stimulation device, and the administration behavior implemented by the administration tube or the administration device in combination with the optical fiber for optical stimulation, which will not be described in detail herein.

In addition, the process or principle of the administration action realized by the administration tube or the administration device, the optical stimulation performed by combining the optical fiber, and the electrophysiological experiment performed by combining different types of electrodes can be referred to the prior art, and will not be elaborated herein.

In addition, it should be further noted that, the sizes of the first tube 100 and the second tube 200 in the above embodiments are not limited thereto, and an experimenter can adjust themselves according to his own experimental purpose, but the difference between the thicknesses of the first tube 100 and the second tube 200 cannot be too large, otherwise, sealing is not easily achieved, and later-period medicine injection is not performed or metering is not accurate, and finally, an experiment fails.

Finally, it should be noted that: the above embodiments are only used to illustrate the technical solution of the present invention, and not to limit the same; although the present invention has been described in detail with reference to the foregoing embodiments, it should be understood by those skilled in the art that: the technical solutions described in the foregoing embodiments may still be modified, or some or all of the technical features may be equivalently replaced; such modifications and substitutions do not depart from the spirit and scope of the present invention.

Claims

1. An administration tube, comprising: a first pipe body (100) and a second pipe body (200) hermetically connected to each other;

the first tube (100) is used for being implanted into the brain region, the outer diameter range of the first tube (100) is 350-;

the second tube (200) is used for connecting with a medicine feeding device, the hardness of the second tube (200) is smaller than that of the first tube (100), and the inner diameter of the second tube (200) is not smaller than the outer diameter of the first tube (100).

2. The administration tube according to claim 1, wherein the second tube (200) has an outer diameter in the range of 900-1100 μm and an inner diameter in the range of 450-550 μm.

3. The administration tube according to claim 2, wherein the first tube (100) has an outer diameter of 356 μm and an inner diameter of 182 μm;

and/or the outer diameter of the second pipe body (200) is 1000 mu m, and the inner diameter is 500 mu m.

4. The administration tube according to any of claims 1 to 3, wherein one end of the first tube (100) is insertable into the second tube (200) and the depth of insertion of the first tube (100) into the second tube (200) is 5 mm.

5. The administration tube according to claim 4, wherein the first tube (100) and the second tube (200) are connected by a sealant.

6. The administration tube according to claim 4, wherein the first tube (100) has a truncated length dimension that is greater than a depth dimension of the brain region of implantation by 1 cm;

and/or the cut length of the second pipe body (200) is 3 cm.

7. The administration tube according to any of claims 1 to 3, wherein the first tube (100) is a silicon tube, a glass tube or a polymer tube;

and/or the second pipe body (200) is a plastic pipe or a rubber pipe.

8. The administration tube according to claim 1, wherein the drug delivery device comprises at least an injector, the output end of which is intended to be connected to the end of the second body (200) remote from the first body (100).

9. A drug delivery device comprising a delivery tube according to any one of claims 1 to 8.

10. A neuropsychiatric disease treatment system comprising the drug delivery device of claim 9;

alternatively, a device comprising an electrophysiological recording device and the drug delivery device of claim 9;

alternatively, a light stimulation device and a drug delivery device according to claim 9;

alternatively, comprising an electrophysiological recording device, a light stimulation device and a drug delivery device as claimed in claim 9.