CN210992583U

CN210992583U - Easily dissolved microneedle structure

Info

Publication number: CN210992583U
Application number: CN201921186517.9U
Authority: CN
Inventors: 不公告发明人
Original assignee: Youwei Zhuhai Biotechnology Co ltd
Current assignee: Youwei Zhuhai Biotechnology Co ltd
Priority date: 2019-07-25
Filing date: 2019-07-25
Publication date: 2020-07-14
Anticipated expiration: 2029-07-25

Abstract

The utility model discloses a high-solubility micro-needle structure, comprising a needle body, the needle body includes needle point portion and needle bottom, the surface of needle point portion is the curved surface, the cross section of needle point portion is circular and diameter by supreme diminishing gradually down to being zero, the needle bottom is the polygon prism of indent, transition connection about needle point portion and needle bottom. This microneedle portion surface of micropin structure is the curved surface, the cross section of pinpoint portion is circular and diameter by supreme diminishing gradually down to being zero, when guaranteeing certain mechanical strength, easily pierce in the skin, and the needle bottom is the polygon prism of indent, the form design of needle bottom, obtain great surface area with less volume, increase with the area of contact of skin, the needle bottom can be dissolved fast and fracture in the skin, make needle body and substrate break away from fast, save the time that the substrate pasted on skin, and transition connection about pinpoint portion and the needle bottom, the form design is very reasonable.

Description

Easily dissolved microneedle structure

Technical Field

The utility model relates to a medical treatment and cosmetic field especially relate to soluble micropin.

Background

The painless transdermal drug delivery of the microneedle is used as a novel drug delivery technology, can create a micron-sized drug delivery channel on the skin painlessly, enhances the permeability of the skin to active substances or drugs, particularly macromolecular drugs, and represents the development direction of the percutaneous in-vivo conduction of the drugs in the future due to the advantages of painless, safe, easy operation and the like.

The manufacturing process of the soluble microneedle at the present stage mainly comprises two main types, namely a mould shaping mode and a stretching shaping mode. For the stretching and shaping mode, the microneedle structure is formed by contacting and stretching viscous macromolecule liquid drops, and the shape of the manufactured microneedle cannot be freely controlled due to the fact that the manufacturing process utilizes the stretching and extending characteristics of viscous fluid; in the mold method, a viscous polymer material needs to be poured into a micro-needle mold of a micrometer scale by an external force method such as centrifugation or vacuum pumping, and thus the diameter/area of the bottom of the micro-needle mold needs to be larger than that of the tip of the needle, so that the viscous solution can be easily and completely filled into the mold.

In consideration of the limitations of the manufacturing process, when designing a microneedle structure, the taper and volume of the microneedle are reduced as much as possible in order to easily pierce the skin, but a certain mechanical strength is lost, and if the mechanical strength of the microneedle is reduced, the microneedle is likely to bend and break when piercing the skin. In addition, after the microneedle is penetrated into the skin, the bottom of the microneedle needs to be dissolved and broken in the skin quickly, so that the microneedle body is separated from the substrate quickly, the needle tip part can be retained in the skin to play a slow-release effect, the substrate does not need to be adhered to the skin for a long time to prevent discomfort, the dissolving speed of the bottom of the microneedle is related to the contact area with the skin, the larger the surface area is, the faster the dissolving speed is, and therefore a microneedle structure with a reasonable shape design is urgently needed.

SUMMERY OF THE UTILITY MODEL

The utility model aims to solve one of the technical problem that exists among the prior art at least, provide a micropin structure, its form reasonable in design possesses certain mechanical strength, easily pierces skin and micropin bottom and can dissolve fast.

The utility model provides a technical scheme that its technical problem adopted does:

easily dissolve micropin structure, including the needle body, the needle body includes pinpoint portion and needle bottom, the surface of pinpoint portion is the curved surface, the cross section of pinpoint portion is circular and diameter from lower supreme diminishing gradually to zero, the needle bottom is the polygon prism of indent, pinpoint portion and needle bottom transitional coupling from top to bottom.

As an improvement of the technical scheme, the tangential inclination angle of the outer surface of the needle tip part is gradually reduced from bottom to top.

As an improvement of the above technical solution, the top of the needle tip part has a tip point, and any peripheral line of the longitudinal section of the needle tip part passing through the tip point is continuously non-conductive at the tip point.

As an improvement of the technical scheme, the top outer surface of the needle tip part is continuously conductive everywhere.

As an improvement of the technical scheme, the bottom of the needle is a regular pentagonal prism with a concave side surface.

As an improvement of the technical scheme, the needle tip part and the needle bottom part are transited to form a middle transition part, the outer surface of the middle transition part is provided with a plurality of convex curved surface sections and a plurality of concave curved surface sections, and the convex curved surface sections and the concave curved surface sections are distributed at intervals one by one.

As an improvement of the technical scheme, the cross-sectional area of the middle transition part is gradually reduced from bottom to top.

The beneficial effects of the utility model are that:

this microneedle portion surface of micropin structure is the curved surface, the cross section of pinpoint portion is circular and diameter by supreme diminishing gradually down to being zero, when guaranteeing certain mechanical strength, easily pierce in the skin, and the needle bottom is the polygon prism of indent, the form design of needle bottom, obtain great surface area with less volume, increase with the area of contact of skin, the needle bottom can be dissolved fast and fracture in the skin, make needle body and substrate break away from fast, save the time that the substrate pasted on skin, and transition connection about pinpoint portion and the needle bottom, the form design is very reasonable.

Drawings

The present invention will be further described with reference to the accompanying drawings and specific embodiments, wherein:

fig. 1 is a schematic structural diagram of a first embodiment of the present invention;

fig. 2 is a top view of a first embodiment of the present invention;

fig. 3 is a front view of the first embodiment of the present invention;

FIG. 4 is a cross-sectional view A-A of FIG. 3;

FIG. 5 is a cross-sectional view B-B of FIG. 3;

fig. 6 is a schematic structural diagram of a second embodiment of the present invention.

Detailed Description

The first embodiment: the utility model provides an easily dissolve micropin structure, see figure 1, including needle body 1, needle body 1 can once fill by the mould and take shape, and needle body 1 includes needle point portion 2, needle bottom 3 and middle transition portion 4, and transition connection about needle point portion 2 and needle bottom 3 passes through between needle point portion 2 and the needle bottom 3 and forms middle transition portion 4.

Further referring to fig. 3 and 5, the outer surface of the needle tip portion 2 is a smooth curved surface, and combines the fluid mechanics principle to reduce the resistance when puncturing the skin, and the cross section of the needle tip portion 2 is circular and the diameter gradually decreases from bottom to top to zero, so that the mechanical strength of the needle tip portion 2 closer to the bottom is higher, and the probability of bending and breaking is reduced.

The needle point part 2 is not a standard cone, and is similar to a convex cone, the tangent inclination angle of the outer surface of the needle point part 2 is gradually reduced from bottom to top, so that the whole process of penetrating the needle point part 2 into the skin is easier, in the first embodiment, the top part of the needle point part 2 is provided with a point 21, as shown in fig. 3 and 5, the outer peripheral line of the longitudinal section of the needle point part passing through the point 21 is continuously non-conductive at the point 21, namely, the tangent of one side of the point 21 is not overlapped with the tangent of the other side, the sharpness of the top part of the needle point part 2 is ensured, and the skin penetration is facilitated while certain mechanical strength is maintained.

Further referring to fig. 2, the needle bottom 3 is a concave polygon prism, specifically a regular pentagonal prism with a concave side surface, and obtains a larger surface area with a smaller volume, so that the contact area with the skin is increased, the needle bottom 3 can be quickly dissolved and broken in the skin, the needle body 1 and the substrate can be quickly separated, and the time for adhering the substrate to the skin is saved.

Further referring to fig. 3 and 4, the outer surface of the middle transition part 4 is provided with a plurality of convex curved sections 41 and a plurality of concave curved sections 42, the convex curved sections 41 and the concave curved sections 42 are distributed at intervals one by one, and the cross-sectional area of the middle transition part 4 is gradually reduced from bottom to top, so that the needle point part 2 which has penetrated into the skin can depend on the connection of the middle transition part 4, the needle bottom part 3 can be smoothly ensured to continuously penetrate into the skin, and the form design of the whole needle body 1 is very reasonable.

Second embodiment: the difference with the first embodiment is that, referring further to fig. 6, the outer surface of the top of the needle tip portion 2 is continuously conductive, only having a vertex and no tip point, so as to ensure the smoothness of the top of the needle tip portion 2, and while ensuring that the skin can be conveniently penetrated, the mechanical strength of the top of the needle tip portion 2 is increased, and the top of the needle tip portion 2 is effectively prevented from bending and breaking.

In addition, it is supplementary to state that the needle tip portion 2 and the needle bottom portion 3 are made of different soluble polymer materials respectively, and subsequent integrated molding is realized by adding the materials successively during filling, wherein the dissolving speed of the needle bottom portion 3 in the skin is faster than that of the needle tip portion 2 in the skin, functional cosmetics or pharmaceutical active ingredients are only carried on the needle tip portion 2, the needle bottom portion 3 usually contains no medicine, and has a quick dissolving effect, and certainly, some needle bottom portions 3 can also be carried with the functional cosmetics or pharmaceutical active ingredients inside; on one hand, the needle tip part 2 can slowly release, so that the utilization rate of the medicine is increased; on the other hand, the administration dosage can be accurately controlled. By adjusting the concentration of the components or polymers of the needle tip portion 2 and the needle bottom portion 3, for example, the material constituting the needle bottom portion 3 is a material which is easily dissolved in water, for example, PVP. After the needle body 1 pierces the skin for a period of time, the needle bottom 3 can be dissolved and broken rapidly, the needle tip part 2 is detained in the skin, the slow release effect is exerted, and the substrate does not need to be stuck on the skin for a long time, so that discomfort is prevented from being caused. Specifically, the material of the needle tip portion 2 can be one or more of chondroitin sulfate, polylactic acid, polyglycolic acid, polylactic acid-glycolic acid copolymer and methyl vinyl ether-maleic anhydride copolymer; the material of the needle bottom 3 can be one or more of polyvinylpyrrolidone, polyethylene glycol, polyvinyl alcohol, carboxymethyl cellulose, carbomer, trehalose, maltose, sucrose, raffinose, hyaluronic acid, sodium alginate, pullulan and dextran.

The above description is only a preferred embodiment of the present invention, but the present invention is not limited to the above embodiments, and the technical effects of the present invention should be all included in the protection scope of the present invention as long as the technical effects are achieved by any of the same or similar means.

Claims

1. Easily dissolve micropin structure, including the needle body, its characterized in that: the needle body includes pinpoint portion and needle bottom, the surface of pinpoint portion is the curved surface, the cross section of pinpoint portion is circular and diameter by supreme diminishing gradually to being zero down, the needle bottom is the polygon prism of indent, pinpoint portion and needle bottom transitional coupling from top to bottom.

2. A lyotropic microneedle structure according to claim 1, characterized in that: the tangent line inclination angle of the outer surface of the needle tip part gradually decreases from bottom to top.

3. A lyotropic microneedle structure according to claim 2, characterized in that: the tip of the needle tip portion has a tip point at which the outer circumference of any longitudinal section of the needle tip portion passing through the tip point is continuously non-conductive.

4. A lyotropic microneedle structure according to claim 2, characterized in that: the top outer surface of the needle tip portion is continuously conductive everywhere.

5. A lyotropic microneedle structure according to claim 1, characterized in that: the bottom of the needle is a regular pentagonal prism with an inwards concave side surface.

6. A lyotropic microneedle structure according to claim 2 or 5, characterized in that: transition forms middle transition portion between needle point portion and the needle bottom, the surface of middle transition portion has a plurality of evagination curved surface sections and a plurality of indent curved surface section, evagination curved surface section and indent curved surface section interval distribution one by one.

7. A lyotropic microneedle structure according to claim 6, characterized in that: the cross-sectional area of the middle transition part is gradually reduced from bottom to top.