CN209302013U

CN209302013U - A kind of solubility micropin

Info

Publication number: CN209302013U
Application number: CN201821093146.5U
Authority: CN
Inventors: 不公告发明人
Original assignee: Yu Wei (zhuhai) Biotechnology Co Ltd
Current assignee: Yu Wei (zhuhai) Biotechnology Co Ltd
Priority date: 2018-07-10
Filing date: 2018-07-10
Publication date: 2019-08-27
Anticipated expiration: 2028-07-10

Abstract

The utility model discloses a kind of soluble micropins, including substrate and multiple needle bodies being distributed on substrate, the needle body includes needle bottom and the needle tip that is arranged on needle bottom, and the needle tip is cone, and the diameter of the needle bottom is not less than the basal diameter of needle tip.The needle body of this micropin includes needle bottom and the needle tip that is arranged on needle bottom, the needle tip is cone, the diameter of the needle bottom is not less than the basal diameter of needle tip, and needle tip combination hydrodynamics is up-narrow and down-wide, reduce the resistance generated when being pierced into skin, micropin is set readily to be pierced into skin, meanwhile, increase the mechanical strength of entire needle structure, the probability for being bent and fractureing when being pierced into skin is reduced, more efficiently progress drug conduction.

Description

A kind of solubility micropin

Technical field

The utility model relates to medical treatment and beauty treatment fields more particularly to a kind of soluble micropins.

Background technique

The painless percutaneous dosing of micropin can be created painlessly micron-sized on the skin as a kind of novel medicine-feeding technology Drug delivery channel, enhancing skin to the permeability of active material or drug especially macromolecular drug, because its have it is painless, The advantages such as safe, easy to operate represent future drugs percutaneously to the developing direction conducted in vivo.

The manufacture craft of soluble micropin is broadly divided into two major classes, mold moulding and stretching moulding mode at this stage.For For mould profile, need sticky high molecular material being filled into micron level in the way of the external force for being centrifuged and vacuumizing In micropin mold, it is therefore desirable to micropin mold design are greater than tip portion at base diameter, viscosity solution is made to be easy to complete It is filled in mold；And for stretching moulding mode, be always by contact tensile viscosity macromolecule drop formed it is micro- Needle construction, since the stretching extension characteristics that viscous fluid has are utilized in manufacturing process so that the micropin form made without Method freely controls, simultaneously because the limitation of manufacture craft, tip portion diameter can not be minimized, so that the microneedle configuration is more difficult Be pierced into skin and if reducing the mechanical strength of micropin simply be easy to produce the problem of bending fractures when being pierced into skin, remove this with Outside, due to the natural elasticity of skin texture and self-recovery power, micropin is easy to be detached from skin again being pierced into after skin Skin surface.

Utility model content

In order to overcome the above-mentioned deficiencies of the prior art, the utility model provides a kind of soluble micropin, is conducive to be pierced into Skin, and not flexible fracture.

The utility model solves technical solution used by its technical problem are as follows:

It is a kind of solubility micropin, including substrate and multiple needle bodies being distributed on substrate, the needle body include needle bottom and Needle tip on needle bottom is set, and the needle tip is cone, and the diameter of the needle bottom is not less than the bottom surface of needle tip Diameter.

As an improvement of the above technical solution, the needle bottom includes cylindrical body, the top surface of the cylindrical body and needle tip Bottom surface be overlapped.

As an improvement of the above technical solution, the needle bottom further includes round estrade, and the round estrade is set to cylindrical body Lower end, the top surface of the round estrade are overlapped with the bottom surface of cylindrical body.

As an improvement of the above technical solution, the needle bottom is round estrade, the top surface of the needle bottom and needle tip Bottom surface is overlapped.

As an improvement of the above technical solution, the taper of the needle bottom is less than the taper of needle tip.

As an improvement of the above technical solution, the needle bottom is multistage round estrade, the most top surface of higher level's round estrade and needle The bottom surface of tip is overlapped, and the most taper of higher level's round estrade is less than the taper of needle tip, the top surface of next stage round estrade and upper level The bottom surface of round estrade is overlapped, and the taper of next stage round estrade is less than the taper of upper level round estrade.

As an improvement of the above technical solution, the needle bottom is multistage stepped round estrade, most higher level's round estrade Top surface diameter be greater than the basal diameter of needle tip, the bottom surface that the top surface diameter of next stage round estrade is greater than upper level round estrade is straight Diameter.

As an improvement of the above technical solution, the taper of round estrade and the taper of needle tip are consistent.

As an improvement of the above technical solution, the range of taper of the needle tip be 1:10~1:1, altitude range be 50~ 5000 μm, basal diameter range is 50~500 μm.

As an improvement of the above technical solution, the needle tip is made of soluble high-molecular material.

The beneficial effects of the utility model have:

The needle body of this micropin includes needle bottom and the needle tip that is arranged on needle bottom, and the needle tip is cone, institute The diameter for stating needle bottom is not less than the basal diameter of needle tip, and needle tip combination hydrodynamics is up-narrow and down-wide, reduces and is pierced into skin When the resistance that generates, so that micropin is readily pierced into skin, meanwhile, increase the mechanical strength of entire needle structure, reduce The probability to fracture is bent when being pierced into skin, more efficiently progress drug conduction.

Detailed description of the invention

With reference to the accompanying drawing and specific embodiment the utility model is described in further detail, in which:

Fig. 1 is the structural schematic diagram of the utility model embodiment one；

Fig. 2 is the structural schematic diagram of the utility model embodiment two；

Fig. 3 is the structural schematic diagram of the utility model embodiment three；

Fig. 4 is the structural schematic diagram of the utility model embodiment four；

Fig. 5 is the structural schematic diagram of the utility model embodiment five.

Specific embodiment

Referring to Fig. 1 to Fig. 5, a kind of soluble micropin of the utility model, including substrate 1 and multiple distributions are on the substrate 1 Needle body 2, wherein substrate 1 can be pasted on the skin, and the needle body 2 includes needle bottom 22 and being arranged on needle bottom 22 Needle tip 21, equipped with functional cosmetics or active pharmaceutical ingredient inside needle tip 21, the needle tip 21 is cone, institute The diameter for stating needle bottom 22 is not less than the basal diameter of needle tip 21, wherein and the range of taper of needle tip 21 is 1:10~1:1, Altitude range is 50~5000 μm, and basal diameter range is 50~500 μm.

Wherein, needle tip 21 is made of soluble high-molecular material, concretely chondroitin sulfate, polylactic acid, polyethanol Acid, poly lactide-glycolide acid, methyl vinyl ether-maleic anhydride copolymer, gather at polyvinylpyrrolidone Ethylene glycol, polyvinyl alcohol, carboxymethyl cellulose, carbomer, trehalose, maltose, sucrose, gossypose, hyaluronic acid, alginic acid Sodium, amylopectin, glucan one or more mixtures.

Needle bottom 22 can be insoluble material and be made, such as the materials such as Polystyren polymer, ceramics, glass, metal Matter will promptly can be efficiently directed into needle tip 21 to skin, and without waiting for or paste 1 long period of substrate Extract substrate and needle bottom 22；Needle bottom 22 is also possible to soluble material and is made, and also carries inside needle bottom 22 functional Property cosmetics or active pharmaceutical ingredient, by adjusting the ingredient or polymer concentration of needle tip 21 and needle bottom 22, such as form The material of needle bottom 22 is to be easily dissolved in the material of water, such as PVP, alternatively, forming the effective polymer of needle tip 21 Concentration is much larger than effective polymer concentration of needle bottom 22, such as 21 effective component of needle tip is the sodium hyaluronate that concentration is 70%, 22 effective component of needle bottom is the sodium hyaluronate that concentration is 30%, then being pierced into needle bottom 22 after skin is comparatively fast dissolved in skin It is interior, it completes to be rapidly separated, but also substrate 1 can be easily separated skin, be all dissolved within skin without waiting to needle tip 21, it can Soon to take substrate 1 away, prevent from causing discomfort, and needle tip 21 can be trapped in for a long time in skin, play the effect of sustained release Fruit, needle bottom 22 can also be rich in calm dermal drug ingredient or the ingredients that quickly heals, so that the skin that quickly heals after being pierced into skin Skin wound.

The utility model is directed to the form of needle bottom 22, specific as follows there are multiple embodiments:

Embodiment one

Referring to Fig. 1, the needle bottom 22 includes cylindrical body 3, the top surface of the cylindrical body 3 and the bottom surface weight of needle tip 21 It closes, in the present embodiment, after needle tip 21 is pierced into skin, needle bottom 22 is also readily pierced into skin, and resistance is very small, so that whole A needle body 2 can be pierced into the deep layer of skin.

Embodiment two

Referring to fig. 2, compared to implementing one, the needle bottom 22 further includes round estrade 4, and the round estrade 4 is set to cylinder The top surface of 3 lower end of body, the round estrade 4 is overlapped with the bottom surface of cylindrical body 3, in the present embodiment, the taper and needle tip of round estrade 4 21 taper is consistent, and after needle tip 21 is pierced into skin, cylindrical body 3 and round estrade 4 are also readily pierced into skin, and resistance is very It is small, enable entire needle body 2 to be more in depth pierced into the deep layer of skin, meanwhile, round estrade 4 can also reinforce entire needle bottom 22 mechanical strength prevents from fractureing.

Embodiment three

Referring to Fig. 3, the needle bottom 22 is round estrade 4, and the top surface of the needle bottom 22 is overlapped with the bottom surface of needle tip 21, The taper of the needle bottom 22 is less than the taper of needle tip 21, effectively elongated needle body 2 can be pierced into skin, at this In embodiment, after needle tip 21 is pierced into skin, needle bottom 22 is also readily pierced into skin, and resistance is smaller, so that entire needle body 2 It can be pierced into the deep layer of skin, micropin can be effectively adjusted by adjusting 2 length of needle body and 22 width of needle bottom and be pierced into skin Interior depth, while the design of round estrade 4 can also reinforce the mechanical strength of entire needle body 2, prevent from fractureing.

Example IV

Referring to fig. 4, the deformation as embodiment three, the needle bottom 22 are multistage round estrade 4, most higher level's round estrade 4 Top surface is overlapped with the bottom surface of needle tip 21, and the most taper of higher level's round estrade 4 is less than the taper of needle tip 21, next stage round estrade 4 Top surface be overlapped with the bottom surface of upper level round estrade 4, the taper of next stage round estrade 4 is less than the taper of upper level round estrade 4, by Taper in needle bottom 22 reduces step by step, and as the depth for being pierced into skin increases, needle bottom 22 increasingly can readily be pierced into skin Skin, resistance is smaller and smaller, enables entire needle body 2 to be more in depth pierced into the deep layer of skin, while the design of round estrade 4 is also The mechanical strength that can reinforce entire needle body 2, prevents from fractureing.

Embodiment five

Referring to Fig. 5, as the deformation of embodiment three, and it is different from example IV, it is in ladder that the needle bottom 22, which is multistage, The round estrade 4 of shape, the top surface diameter of most higher level's round estrade 4 are greater than the basal diameter of needle tip 21, the top surface of next stage round estrade 4 Diameter is greater than the basal diameter of upper level round estrade 4, and the taper of round estrade 4 is consistent with the taper of needle tip 21, the present embodiment Needle bottom 22 is designed, so that the deep layer that entire needle body 2 gos deep into skin is not so difficult, emphasis reinforces the mechanical strength of entire needle body 2, subtracts The probability to fracture is bent when being pierced into skin less.

The above, the only better embodiment of the utility model, but the utility model is not limited to above-mentioned reality Example is applied, as long as its technical effect for reaching the utility model with any same or similar means, all should belong to the utility model Protection scope.

Claims

1. a kind of solubility micropin, it is characterised in that: including substrate and multiple needle bodies being distributed on substrate, the needle body includes Needle bottom and the needle tip being arranged on needle bottom, the needle tip are cone, and the diameter of the needle bottom is not less than needle point The basal diameter in portion.

2. a kind of soluble micropin according to claim 1, it is characterised in that: the needle bottom includes cylindrical body, described The top surface of cylindrical body is overlapped with the bottom surface of needle tip.

3. a kind of soluble micropin according to claim 2, it is characterised in that: the needle bottom further includes round estrade, institute It states round estrade and is set to cylindrical body lower end, the top surface of the round estrade is overlapped with the bottom surface of cylindrical body.

4. a kind of soluble micropin according to claim 1, it is characterised in that: the needle bottom is round estrade, the needle The top surface of bottom is overlapped with the bottom surface of needle tip.

5. a kind of soluble micropin according to claim 4, it is characterised in that: the taper of the needle bottom is less than needle tip Taper.

6. a kind of soluble micropin according to claim 1, it is characterised in that: the needle bottom is multistage round estrade, most The top surface of higher level's round estrade is overlapped with the bottom surface of needle tip, and the most taper of higher level's round estrade is less than the taper of needle tip, next stage The top surface of round estrade is overlapped with the bottom surface of upper level round estrade, and the taper of next stage round estrade is less than the cone of upper level round estrade Degree.

7. a kind of soluble micropin according to claim 1, it is characterised in that: the needle bottom is multistage stepped Round estrade, the top surface diameter of most higher level's round estrade are greater than the basal diameter of needle tip, and the top surface diameter of next stage round estrade is greater than The basal diameter of upper level round estrade.

8. a kind of soluble micropin according to claim 7, it is characterised in that: the taper of the round estrade and needle tip Taper is consistent.

9. described in any item a kind of soluble micropins according to claim 1~8, it is characterised in that: the taper of the needle tip Range is 1:10~1:1, and altitude range is 50~5000 μm, and basal diameter range is 50~500 μm.

10. described in any item a kind of soluble micropins according to claim 1~8, it is characterised in that: the needle tip is by solvable Property high molecular material is made.