CN108939282A - A kind of high-intensitive soluble micropin - Google Patents
A kind of high-intensitive soluble micropin Download PDFInfo
- Publication number
- CN108939282A CN108939282A CN201810750048.2A CN201810750048A CN108939282A CN 108939282 A CN108939282 A CN 108939282A CN 201810750048 A CN201810750048 A CN 201810750048A CN 108939282 A CN108939282 A CN 108939282A
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- Prior art keywords
- needle
- needle tip
- tip
- intensitive
- skin
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- 239000012530 fluid Substances 0.000 abstract description 4
- 230000008569 process Effects 0.000 abstract description 3
- 230000006872 improvement Effects 0.000 description 9
- 229940079593 drug Drugs 0.000 description 6
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- 238000000465 moulding Methods 0.000 description 3
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 description 2
- 229920002385 Sodium hyaluronate Polymers 0.000 description 2
- 239000008186 active pharmaceutical agent Substances 0.000 description 2
- 229920000036 polyvinylpyrrolidone Polymers 0.000 description 2
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 description 2
- 229940010747 sodium hyaluronate Drugs 0.000 description 2
- YWIVKILSMZOHHF-QJZPQSOGSA-N sodium;(2s,3s,4s,5r,6r)-6-[(2s,3r,4r,5s,6r)-3-acetamido-2-[(2s,3s,4r,5r,6r)-6-[(2r,3r,4r,5s,6r)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2- Chemical compound [Na+].CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 YWIVKILSMZOHHF-QJZPQSOGSA-N 0.000 description 2
- 230000002459 sustained effect Effects 0.000 description 2
- HDTRYLNUVZCQOY-UHFFFAOYSA-N α-D-glucopyranosyl-α-D-glucopyranoside Natural products OC1C(O)C(O)C(CO)OC1OC1C(O)C(O)C(O)C(CO)O1 HDTRYLNUVZCQOY-UHFFFAOYSA-N 0.000 description 1
- KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 description 1
- OWEGMIWEEQEYGQ-UHFFFAOYSA-N 100676-05-9 Natural products OC1C(O)C(O)C(CO)OC1OCC1C(O)C(O)C(O)C(OC2C(OC(O)C(O)C2O)CO)O1 OWEGMIWEEQEYGQ-UHFFFAOYSA-N 0.000 description 1
- SQDAZGGFXASXDW-UHFFFAOYSA-N 5-bromo-2-(trifluoromethoxy)pyridine Chemical compound FC(F)(F)OC1=CC=C(Br)C=N1 SQDAZGGFXASXDW-UHFFFAOYSA-N 0.000 description 1
- NIXOWILDQLNWCW-UHFFFAOYSA-N Acrylic acid Chemical compound OC(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 description 1
- 229920000945 Amylopectin Polymers 0.000 description 1
- 229920002134 Carboxymethyl cellulose Polymers 0.000 description 1
- 229920001287 Chondroitin sulfate Polymers 0.000 description 1
- 229920001503 Glucan Polymers 0.000 description 1
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 1
- GUBGYTABKSRVRQ-PICCSMPSSA-N Maltose Natural products O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@@H](CO)OC(O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-PICCSMPSSA-N 0.000 description 1
- 229920000954 Polyglycolide Polymers 0.000 description 1
- 239000004372 Polyvinyl alcohol Substances 0.000 description 1
- 206010072170 Skin wound Diseases 0.000 description 1
- 229920002125 Sokalan® Polymers 0.000 description 1
- 229930006000 Sucrose Natural products 0.000 description 1
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 1
- HDTRYLNUVZCQOY-WSWWMNSNSA-N Trehalose Natural products O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@H](O)[C@@H](O)[C@@H](O)[C@@H](CO)O1 HDTRYLNUVZCQOY-WSWWMNSNSA-N 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 239000011149 active material Substances 0.000 description 1
- 239000000783 alginic acid Substances 0.000 description 1
- 229920000615 alginic acid Polymers 0.000 description 1
- 235000010443 alginic acid Nutrition 0.000 description 1
- 229960001126 alginic acid Drugs 0.000 description 1
- 150000004781 alginic acids Chemical class 0.000 description 1
- HDTRYLNUVZCQOY-LIZSDCNHSA-N alpha,alpha-trehalose Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 HDTRYLNUVZCQOY-LIZSDCNHSA-N 0.000 description 1
- 230000003796 beauty Effects 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- GUBGYTABKSRVRQ-QUYVBRFLSA-N beta-maltose Chemical compound OC[C@H]1O[C@H](O[C@H]2[C@H](O)[C@@H](O)[C@H](O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@@H]1O GUBGYTABKSRVRQ-QUYVBRFLSA-N 0.000 description 1
- 229960001631 carbomer Drugs 0.000 description 1
- 239000001768 carboxy methyl cellulose Substances 0.000 description 1
- 235000010948 carboxy methyl cellulose Nutrition 0.000 description 1
- 239000008112 carboxymethyl-cellulose Substances 0.000 description 1
- 239000000919 ceramic Substances 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 229940059329 chondroitin sulfate Drugs 0.000 description 1
- 238000010276 construction Methods 0.000 description 1
- 229920001577 copolymer Polymers 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 238000004090 dissolution Methods 0.000 description 1
- 238000012377 drug delivery Methods 0.000 description 1
- 230000002500 effect on skin Effects 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 230000002708 enhancing effect Effects 0.000 description 1
- 239000011521 glass Substances 0.000 description 1
- 230000035876 healing Effects 0.000 description 1
- 229920002674 hyaluronan Polymers 0.000 description 1
- 229960003160 hyaluronic acid Drugs 0.000 description 1
- WGCNASOHLSPBMP-UHFFFAOYSA-N hydroxyacetaldehyde Natural products OCC=O WGCNASOHLSPBMP-UHFFFAOYSA-N 0.000 description 1
- 238000001727 in vivo Methods 0.000 description 1
- 239000002198 insoluble material Substances 0.000 description 1
- 229920002521 macromolecule Polymers 0.000 description 1
- 229910052751 metal Inorganic materials 0.000 description 1
- 239000002184 metal Substances 0.000 description 1
- -1 methyl vinyl Chemical group 0.000 description 1
- 230000035699 permeability Effects 0.000 description 1
- 229920000747 poly(lactic acid) Polymers 0.000 description 1
- 239000004633 polyglycolic acid Substances 0.000 description 1
- 239000004626 polylactic acid Substances 0.000 description 1
- 229920002223 polystyrene Polymers 0.000 description 1
- 229920002451 polyvinyl alcohol Polymers 0.000 description 1
- 239000001267 polyvinylpyrrolidone Substances 0.000 description 1
- MUPFEKGTMRGPLJ-ZQSKZDJDSA-N raffinose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO[C@@H]2[C@@H]([C@@H](O)[C@@H](O)[C@@H](CO)O2)O)O1 MUPFEKGTMRGPLJ-ZQSKZDJDSA-N 0.000 description 1
- 238000011084 recovery Methods 0.000 description 1
- 230000036548 skin texture Effects 0.000 description 1
- 229910052708 sodium Inorganic materials 0.000 description 1
- 239000011734 sodium Substances 0.000 description 1
- 239000005720 sucrose Substances 0.000 description 1
- 238000013268 sustained release Methods 0.000 description 1
- 239000012730 sustained-release form Substances 0.000 description 1
- VJDDQSBNUHLBTD-UHFFFAOYSA-N trans-crotonic acid-anhydride Natural products CC=CC(=O)OC(=O)C=CC VJDDQSBNUHLBTD-UHFFFAOYSA-N 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
- A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
- A61M2037/0007—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin having means for enhancing the permeation of substances through the epidermis, e.g. using suction or depression, electric or magnetic fields, sound waves or chemical agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
- A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
- A61M2037/0023—Drug applicators using microneedles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
- A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
- A61M2037/0046—Solid microneedles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2205/00—General characteristics of the apparatus
- A61M2205/02—General characteristics of the apparatus characterised by a particular materials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2210/00—Anatomical parts of the body
- A61M2210/04—Skin
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Dermatology (AREA)
- Medical Informatics (AREA)
- Anesthesiology (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Hematology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Media Introduction/Drainage Providing Device (AREA)
- Infusion, Injection, And Reservoir Apparatuses (AREA)
Abstract
The invention discloses a kind of high-intensitive soluble micropins, including substrate and multiple needle bodies being distributed on substrate, the needle body includes needle tip, the outer surface of the needle tip is smooth curved surface, the cross section of the needle tip is that round and diameter is gradually become smaller from the bottom to top until being zero, the tangential tilt angle of the outer surface of the needle tip gradually becomes smaller from the bottom to top.The needle structure combination fluid mechanics principle of this micropin, reduce resistance when being pierced into skin, the outer surface of needle tip is smooth curved surface, cross section is that round and diameter is gradually become smaller from the bottom to top until being zero, so that mechanical strength of the needle tip closer to bottom is higher, the probability that bending fractures is reduced, the tangential tilt angle of outer surface gradually becomes smaller from the bottom to top, so that the process that entire needle tip is pierced into skin is increasingly easy.
Description
Technical field
The present invention relates to medical treatment and beauty treatment fields more particularly to a kind of high-intensitive soluble micropins.
Background technique
The painless percutaneous dosing of micropin can be created painlessly micron-sized on the skin as a kind of novel medicine-feeding technology
Drug delivery channel, enhancing skin to the permeability of active material or drug especially macromolecular drug, because its have it is painless,
The advantages such as safe, easy to operate represent future drugs percutaneously to the developing direction conducted in vivo.
The manufacture craft of soluble micropin is broadly divided into two major classes, mold moulding and stretching moulding mode at this stage.For
For mould profile, need sticky high molecular material being filled into micron level in the way of the external force for being centrifuged and vacuumizing
In micropin mold, it is therefore desirable to micropin mold design are greater than tip portion at base diameter, viscosity solution is made to be easy to complete
It is filled in mold；And for stretching moulding mode, be always by contact tensile viscosity macromolecule drop formed it is micro-
Needle construction, since the stretching extension characteristics that viscous fluid has are utilized in manufacturing process so that the micropin form made without
Method freely controls, simultaneously because the limitation of manufacture craft, microneedle configuration is difficult to be pierced into skin, if reducing the machine of micropin simply
Tool intensity is easy to produce the problem of bending fractures when being pierced into skin, in addition to this, due to the natural elasticity of skin texture and
Self-recovery power, micropin are easy to be detached from skin surface again being pierced into after skin.
Summary of the invention
In order to overcome the above-mentioned deficiencies of the prior art, the present invention provides a kind of high-intensitive soluble micropins, in conjunction with stream
Mechanics, conducive to being pierced into skin and not allowing flexible fracture.
The technical solution adopted by the present invention to solve the technical problems are as follows:
A kind of high-intensitive soluble micropin, including substrate and multiple needle bodies being distributed on substrate, the needle body includes needle
Tip, the outer surface of the needle tip are smooth curved surface, the cross section of the needle tip be round and diameter from the bottom to top by
Gradual change is small until being zero, the tangential tilt angle of the outer surface of the needle tip gradually becomes smaller from the bottom to top.
As an improvement of the above technical solution, the top of the needle tip has tip point, any needle by tip point
The outer peripheral lines in tip vertical section can not continuously be led at the point of tip.
As an improvement of the above technical solution, the outer surface of cupular part everywhere continuous of the needle tip can be led.
As an improvement of the above technical solution, the needle body further includes the needle bottom for being set to needle tip lower end, the needle
The area of the arbitrary cross section of bottom is not less than the base area of needle tip.
As an improvement of the above technical solution, the needle tip and needle bottom are respectively by different soluble high-molecular materials
It is made, wherein solution rate of the needle bottom in skin is fast compared with solution rate of the needle tip in skin.
As an improvement of the above technical solution, the needle bottom includes cylindrical body, the top surface of the cylindrical body and needle tip
Bottom surface be overlapped.
As an improvement of the above technical solution, the needle bottom further includes round estrade, and the round estrade is set to cylindrical body
Lower end, the top surface of the round estrade are overlapped with the bottom surface of cylindrical body, and the bottom of the round estrade is set on substrate.
As an improvement of the above technical solution, the needle bottom is round estrade, the top surface of the round estrade and needle tip
Bottom surface is overlapped, and the bottom of the round estrade is set on substrate.
As an improvement of the above technical solution, the tangential tilt of the outer surface bottom end of the slope angle of the round estrade and needle tip
Angle is consistent.
As an improvement of the above technical solution, the altitude range of the needle body is 50~5000 μm, and basal diameter range is
50~500 μm, the ratio range of basal diameter and height is 0.1~1.
The beneficial effects of the present invention are as follows:
The needle structure combination fluid mechanics principle of this micropin reduces resistance when being pierced into skin, the outer surface of needle tip
For smooth curved surface, cross section is that round and diameter is gradually become smaller from the bottom to top until being zero, so that needle tip is closer to bottom
Mechanical strength it is higher, reduce the probability that fractures of bending, the tangential tilt angle of outer surface gradually becomes smaller from the bottom to top, so that whole
The process that a needle tip is pierced into skin is increasingly easy.
Detailed description of the invention
With reference to the accompanying drawing and specific embodiment the invention will be further described, in which:
Fig. 1 is the structural schematic diagram of the embodiment of the present invention one；
Fig. 2 is the structural schematic diagram of the embodiment of the present invention two；
Fig. 3 is the structural schematic diagram of the embodiment of the present invention three；
Fig. 4 is the structural schematic diagram of the embodiment of the present invention four；
Fig. 5 is the structural schematic diagram of the embodiment of the present invention five.
Specific embodiment
Referring to Fig. 1 to Fig. 5, a kind of high-intensitive soluble micropin of the invention, including substrate 1 and multiple it is distributed in substrate 1
On needle body 2, wherein substrate 1 can be pasted on the skin, inside needle body 2 equipped with functional cosmetics or pharmaceutical activity at
Point, specifically, the altitude range of the needle body 2 is 50~5000 μm, and basal diameter range is 50~500 μm, basal diameter with
The ratio range of height is 0.1~1.
Wherein, the needle body 2 includes needle tip 21, and the outer surface of the needle tip 21 is smooth curved surface, in conjunction with fluid
Mechanics principle, reduces resistance when being pierced into skin, and the cross section of the needle tip 21 is that round and diameter gradually becomes from the bottom to top
It is small until be zero so that mechanical strength of the needle tip 21 closer to bottom is higher, reduce the probability that bending fractures, the needle tip
The tangential tilt angle of 21 outer surface gradually becomes smaller from the bottom to top, so that entire needle tip 21 is pierced into the process of skin increasingly
It is easy.
As for the specific form of needle tip 21, there are two embodiments for present invention tool, as follows:
Embodiment one
The bottom of needle tip 21 is set on substrate 1, and the top of needle tip 21 has tip point 211, any by tip point
The outer peripheral lines in 211 needle tip vertical section can not continuously be led at tip point 211, i.e., the tangent line of 211 side of tip point with it is another
The tangent line of side is not overlapped, and guarantees that the acuteness at the top of needle tip 21 is especially advantageous for piercing while keeping certain mechanical strength
Enter skin.
Embodiment two
The bottom of needle tip 21 is set on substrate 1, and the outer surface of cupular part everywhere continuous of the needle tip 21 can be led, and guarantees needle
The top of tip 21 has rounding, while guaranteeing easily to be pierced into skin, increases the mechanical strength of needle tip 21,
There is the case where bending fractures in the top for being effectively prevented needle tip 21.
In addition, in other embodiments, needle body 2 uses combining form, including needle tip 21 and is set under needle tip 21
The needle bottom 22 at end, the area of the arbitrary cross section of the needle bottom 22 are not less than the base area of needle tip 21, the needle point
Portion 21 and needle bottom 22 are made of different soluble high-molecular materials respectively, wherein dissolution speed of the needle bottom 22 in skin
Degree is fast compared with solution rate of the needle tip in skin, and functional cosmetics or active pharmaceutical ingredient are only equipped on needle tip 21, needle
On the one hand drug containing, instant effect can be sustained for bottom 22, increase drug availability；On the other hand administration can accurately be controlled
Dosage.It can also be equipped with functional cosmetics or active pharmaceutical ingredient, by adjusting needle tip 21 and needle inside needle bottom 22
The ingredient or polymer concentration of bottom 22, for example, composition needle bottom 22 material be easily dissolved in the material of water, such as
PVP.After needle body 2 is pierced into skin for a period of time, the rapidly dissolvable fracture in needle bottom 22, needle tip 21 is trapped in skin, is played
The effect being sustained out, meanwhile, substrate 1 does not just have to permanent stickup on the skin, prevents from causing discomfort.Wherein, the material of needle tip 21
Concretely chondroitin sulfate, polylactic acid, polyglycolic acid, poly lactide-glycolide acid, methyl vinyl ether-are suitable for material
One or more mixtures of crotonic anhydride copolymer；The material of needle bottom 22 concretely polyvinylpyrrolidone, poly- second
Glycol, polyvinyl alcohol, carboxymethyl cellulose, carbomer, trehalose, maltose, sucrose, gossypose, hyaluronic acid, alginic acid
Sodium, amylopectin, glucan one or more mixtures.
It is made in addition, needle tip 21 and needle bottom 22 can be identical soluble high-molecular material, but concentration is different,
Form the effective polymer of needle tip 21 concentration be much larger than needle bottom 22 effective polymer concentration, such as needle tip 21 effectively at
Point be the sodium hyaluronate that concentration is 70%, 22 effective component of needle bottom is the sodium hyaluronate that concentration is 30%, then be pierced into skin it
Needle bottom 22 is comparatively fast dissolved in skin afterwards, completes to be rapidly separated, but also substrate 1 can be easily separated skin, without waiting to needle
Tip 21 is all dissolved within skin, can soon take substrate 1 away, prevents from causing discomfort, and needle tip 21 can be stagnant for a long time
It staying in skin, plays the effect of sustained release, needle bottom 22 can also be rich in calm dermal drug ingredient or the ingredient that quickly heals, with
As for quick healing skin wound after piercing skin.
Needle bottom 22 can also be that insoluble material is made, such as Polystyren polymer, ceramics, glass, metal etc.
Material will promptly can be efficiently directed into needle tip 21 to skin, and without waiting for or paste 1 long period of substrate i.e.
Substrate and needle bottom 22 can be extracted.
Specifically, the form of embodiment one and embodiment two can be used in needle tip 21, as the specific form of needle bottom 22,
The present invention also has there are three embodiment, as follows:
Embodiment three
Needle bottom 22 is cylindrical body 3, and the top surface of the cylindrical body 3 is overlapped with the bottom surface of needle tip 21, the bottom of cylindrical body 3
On substrate 1, needle tip 21 is using the same form of embodiment two, and after needle tip 21 is pierced into skin, cylindrical body 3 also can
Skin is easily penetrated, resistance is very small, effectively increases the mechanical strength of entire needle body, and can be pierced into the depth of skin
Layer.
Example IV
Needle bottom 22 includes cylindrical body 3 and round estrade 4, and the round estrade 4 is set to 3 lower end of cylindrical body, the cylindrical body 3
Top surface be overlapped with the bottom surface of needle tip 21, the top surface of round estrade 4 is overlapped with the bottom surface of cylindrical body 3, the bottom of the round estrade 4
On substrate 1, needle tip 21 uses the same form of embodiment two, after needle tip 21 is pierced into skin, cylindrical body 3 and rotary table
Body 4 can also easily penetrate skin, and resistance is very small, and cylindrical body 3 can effectively support needle tip 21, and round estrade 4 is again
Cylindrical body 3 can be effectively supported, entire needle body 2 can be deeper into the deep layer of skin, by adjusting 4 width of round estrade and needle
The height of tip 21 and cylindrical body 4 can effectively adjust the depth that microneedle configuration is pierced into skin.
Embodiment five
Needle bottom 22 is round estrade 4, and the top surface of the round estrade 4 is overlapped with the bottom surface of needle tip 21, the round estrade 4
Bottom is set on substrate 1, same form of the needle tip 21 using embodiment one, slope angle and the needle tip 21 of the round estrade 4
The tangential tilt angle of outer surface bottom end is consistent, and after needle tip 21 is pierced into skin, round estrade 4 also can successfully continue to be pierced into
In skin, round estrade 4 can effectively support needle tip 21, and the mechanical strength of entire needle body 2 is very high, be not easily broken bending,
And the deep layer of skin can be pierced into.
The above, only better embodiment of the invention, but the present invention is not limited to above-described embodiments, as long as
The technical effect of the present invention is achieved by any identical or similar means for it, all should belong to protection scope of the present invention.
Claims (10)
1. a kind of high-intensitive soluble micropin, it is characterised in that: including substrate and multiple needle bodies being distributed on substrate, the needle
Body includes needle tip, and the outer surface of the needle tip is smooth curved surface, the cross section of the needle tip be round and diameter by
Under it is supreme gradually become smaller until be zero, the tangential tilt angle of the outer surface of the needle tip gradually becomes smaller from the bottom to top.
2. a kind of high-intensitive soluble micropin according to claim 1, it is characterised in that: the top of the needle tip has
The outer peripheral lines of tip point, any needle tip vertical section by tip point can not continuously be led at the point of tip.
3. a kind of high-intensitive soluble micropin according to claim 1, it is characterised in that: the top appearance of the needle tip
Face everywhere continuous can be led.
4. described in any item a kind of high-intensitive soluble micropins according to claim 1~3, it is characterised in that: the needle body is also
Needle bottom including being set to needle tip lower end, the area of the arbitrary cross section of the needle bottom are not less than the bottom surface face of needle tip
Product.
5. a kind of high-intensitive soluble micropin according to claim 4, it is characterised in that: the needle tip and needle bottom point
It is not made of different soluble high-molecular materials, wherein solution rate of the needle bottom in skin is compared with needle tip in skin
Solution rate it is fast.
6. a kind of high-intensitive soluble micropin according to claim 4, it is characterised in that: the needle bottom includes cylinder
Body, the top surface of the cylindrical body are overlapped with the bottom surface of needle tip.
7. a kind of high-intensitive soluble micropin according to claim 6, it is characterised in that: the needle bottom further includes rotary table
Body, the round estrade are set to cylindrical body lower end, and the top surface of the round estrade is overlapped with the bottom surface of cylindrical body, the round estrade
Bottom is set on substrate.
8. a kind of high-intensitive soluble micropin according to claim 4, it is characterised in that: the needle bottom is round estrade,
The top surface of the round estrade is overlapped with the bottom surface of needle tip, and the bottom of the round estrade is set on substrate.
9. a kind of high-intensitive soluble micropin according to claim 8, it is characterised in that: the slope angle and needle of the round estrade
The tangential tilt angle of the outer surface bottom end of tip is consistent.
10. a kind of high-intensitive soluble micropin according to claim 1, it is characterised in that: the altitude range of the needle body
It is 50~5000 μm, basal diameter range is 50~500 μm, and the ratio range of basal diameter and height is 0.1~1.
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810750048.2A CN108939282B (en) | 2018-07-10 | 2018-07-10 | High-strength soluble microneedle |
| CN202311867843.7A CN117797393A (en) | 2018-07-10 | 2018-07-10 | High-strength soluble microneedle |
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| Application Number | Priority Date | Filing Date | Title |
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| CN201810750048.2A CN108939282B (en) | 2018-07-10 | 2018-07-10 | High-strength soluble microneedle |
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| CN202311867843.7A Division CN117797393A (en) | 2018-07-10 | 2018-07-10 | High-strength soluble microneedle |
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| CN108939282B CN108939282B (en) | 2024-09-24 |
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| CN201810750048.2A Active CN108939282B (en) | 2018-07-10 | 2018-07-10 | High-strength soluble microneedle |
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| CN111939452A (en) * | 2019-05-15 | 2020-11-17 | 微邦科技股份有限公司 | Microneedle structure and biodegradable microneedle thereof |
| WO2022140984A1 (en) * | 2020-12-28 | 2022-07-07 | 深圳由莱智能电子有限公司 | Cosmetic handle |
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Also Published As
| Publication number | Publication date |
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| CN117797393A (en) | 2024-04-02 |
| CN108939282B (en) | 2024-09-24 |
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