CN210905039U

CN210905039U - A recrystallization purification device for camptothecin

Info

Publication number: CN210905039U
Application number: CN201921751287.6U
Authority: CN
Inventors: 蒲忠成
Original assignee: Chengdu Xinguang Biotechnology Co ltd
Current assignee: Chengdu Xinguang Biotechnology Co ltd
Priority date: 2019-10-17
Filing date: 2019-10-17
Publication date: 2020-07-03
Anticipated expiration: 2029-10-17

Abstract

The utility model discloses a recrystallization purification device for camptothecin, include: the dissolving tank is provided with a feeding port and a liquid adding port, and a mixing component is arranged in the dissolving tank; a heating cavity with a water filling port and a water discharging port is arranged outside the dissolving tank, and a plurality of electric heating pipes are arranged in the heating cavity; the bottom of the dissolving tank is communicated with the top of the buffer cavity through a liquid outlet pipe; a rotary roller is arranged in the buffer cavity, and a dispersion rod is arranged on the outer surface of the rotary roller in a surrounding manner; the bottom of the buffer cavity is communicated with the top of the crystallizing tank through a liquid separating pipe; a cooling cavity is arranged outside the crystallizing tank; a filter screen and a funnel-shaped partition plate are sequentially arranged in the crystallization tank from bottom to top, and a second electromagnetic valve is arranged at a leakage opening of the partition plate; a plurality of cooling plates are vertically arranged in the crystallizing tank above the partition plate; the crystallizer is characterized in that a crystallizer discharging opening is formed in the side wall of the crystallizer on one side of the filter screen, and a liquid discharging opening is formed in the bottom of the crystallizer. The utility model provides a recrystallization purification device for camptothecin, it is effectual and efficient to recrystallize.

Description

A recrystallization purification device for camptothecin

Technical Field

The utility model relates to a camptothecin production field especially relates to a recrystallization purification device for camptothecin.

Background

Camptothecin is an alkaloid widely distributed in roots, bark, stems and seeds of camptotheca acuminata which is a Chinese dive arborescens in eclipta of southern China, has strong antitumor activity, and is particularly effective on digestive tract tumors, leukemia, chorionic epithelial carcinoma and bladder cancer. The extraction and separation of camptothecin mainly utilizes the characteristics that camptothecin is insoluble in water and soluble in organic agents such as ethanol, chloroform and the like, and the camptothecin is dissolved in the solvents through percolation, and then the final product can be obtained through concentration, solvent recovery, separation, purification and drying. During camptothecin purification, camptothecin is often purified by recrystallization to obtain high purity camptothecin. The existing recrystallization device has the disadvantages of uneven cooling, low recrystallization efficiency, poor effect and low processing efficiency.

SUMMERY OF THE UTILITY MODEL

An object of the present invention is to solve at least the above problems and/or disadvantages and to provide at least the advantages which will be described later.

In order to solve the deficiency of the prior art, the utility model provides a recrystallization purification device for camptothecin, include:

the dissolving tank is provided with a feeding port and a liquid adding port, and a mixing component is arranged in the dissolving tank; a heating cavity with a water filling port and a water discharging port is arranged outside the dissolving tank, and a plurality of electric heating pipes are arranged in the heating cavity; the bottom of the dissolving tank is communicated with the top of the buffer cavity through a liquid outlet pipe, and a first electromagnetic valve is arranged at a pipe orifice at the top of the liquid outlet pipe;

a rotating roller driven to rotate by a motor I is arranged in the buffer cavity, and a dispersing rod is arranged on the outer surface of the rotating roller in a surrounding manner; the bottom of the buffer cavity is communicated with the top of the crystallizing tank through at least 2 liquid separating pipes;

a cooling cavity is arranged outside the crystallizing tank, and is provided with a refrigerant inlet pipe and a refrigerant outlet pipe; a filter screen and a funnel-shaped partition plate are sequentially arranged in the crystallization tank from bottom to top, and a second electromagnetic valve is arranged at a leakage opening of the partition plate; a plurality of cooling plates which are uniformly arranged are vertically arranged in the crystallizing tank above the partition plate, and the front side and the rear side of each cooling plate are communicated with the cooling cavity; the crystallizer is characterized in that a crystallizer discharging opening is formed in the side wall of the crystallizer on one side of the filter screen, and a liquid discharging opening is formed in the bottom of the crystallizer.

Preferably, the electric heating tube has a spiral structure.

Preferably, the mixing assembly comprises a second motor, a mixing rod, a helical blade and a plurality of auxiliary blades, the mixing rod is in transmission connection with the second motor, and the helical blade and the auxiliary blades are installed on the mixing rod.

Preferably, a plurality of radiating fins are arranged on the outer surface of the buffer cavity; and a fan facing the buffer cavity is mounted at the top of the crystallization tank.

Preferably, a plurality of cooling fins are connected between two adjacent cooling fins.

Preferably, the bottom of the dissolving tank is provided with a reinforcing column, and the bottom of the reinforcing column is fixed on the top surface of the crystallizing tank through a heat insulation plate.

The utility model discloses at least, include following beneficial effect:

1. the utility model has simple structure, provides a closed recrystallization environment, prevents the recrystallization process from being polluted by the outside, reduces the generation of impurities, and is beneficial to improving the crystallization purity of the camptothecin;

2. a heating cavity outside the dissolving tank is heated in a water bath, so that the inside of the dissolving tank is uniformly heated, the dissolving speed of camptothecin crystals is accelerated, and meanwhile, the camptothecin and the recrystallization solvent can be stirred and mixed by the mixing component, so that the camptothecin and the recrystallization solvent are fully and uniformly mixed to form recrystallization liquid, the phenomenon that undissolved camptothecin remained in the recrystallization liquid influences the recrystallization effect is avoided, the complete recrystallization is favorably ensured, and the recrystallization effect is enhanced;

3. the buffer cavity preliminarily cools the recrystallization liquid from the dissolving tank, so that the temperature of the recrystallization liquid entering the crystallizing tank is lower, the crystallizing tank can further cool the recrystallization liquid conveniently, the recrystallization rate is accelerated, and the recrystallization efficiency is improved; the roller drives the dispersion rod to disperse the recrystallization liquid, which is beneficial to accelerating the heat dissipation efficiency of the recrystallization liquid;

4. the cooling cavity of the crystallizing tank is matched with the cooling plate together, and the recrystallization liquid in the crystallizing tank is uniformly cooled, so that the crystallization speed of camptothecin is increased, the recrystallization effect is enhanced, and the processing and production efficiency is improved.

Drawings

Fig. 1 is a schematic structural diagram of a recrystallization purification device for camptothecin according to the present invention.

Reference numerals: 1-a dissolving tank, 11-a feeding port, 12-a liquid feeding port, 13-a liquid outlet pipe, 131-a first electromagnetic valve, 2-a mixing component, 21-a second motor, 22-a mixing rod, 23-a helical blade, 24-an auxiliary blade, 3-a heating cavity, 31-a water injection port, 32-a water discharge port, 33-an electric heating pipe, 4-a buffer cavity, 41-a liquid distribution pipe, 42-a heat dissipation fin, 43-a heat dissipation fin, 5-a rotating roller, 51-a dispersing rod, 6-a crystallization tank, 61-a filter screen, 62-a partition plate, 621-a second electromagnetic valve, 63-a crystal discharge port, 64-a liquid discharge port, 7-a cooling cavity, 71-a refrigerant inlet pipe, 72-a refrigerant outlet pipe, 8-a cooling plate, 9-a fan and 10-a reinforcing column, 101-thermal insulation plate.

Detailed Description

The present invention is further described in detail below with reference to the drawings so that those skilled in the art can implement the invention with reference to the description.

It will be understood that terms such as "having," "including," and "comprising," as used herein, do not preclude the presence or addition of one or more other elements or groups thereof.

Fig. 1 shows a recrystallization purification apparatus for camptothecin of the present invention, comprising:

the dissolving tank 1 is provided with a feeding port 11 and a liquid filling port 12, and a mixing component 2 is arranged in the dissolving tank; a heating cavity 3 with a water filling port 31 and a water draining port 32 is arranged outside the dissolving tank 1, and a plurality of electric heating pipes 33 are arranged in the heating cavity 3; the bottom of the dissolving tank 1 is communicated with the top of the buffer cavity 4 through a liquid outlet pipe 13, and a first electromagnetic valve 131 is arranged at a pipe orifice at the top of the liquid outlet pipe 13;

a rotating roller 5 driven by a motor I to rotate is arranged in the buffer cavity 4, and a dispersing rod 51 is arranged on the outer surface of the rotating roller 5 in a surrounding manner; the bottom of the buffer cavity 4 is communicated with the top of the crystallizing tank 6 through at least 2 liquid separating pipes 41;

a cooling cavity 7 is arranged outside the crystallization tank 6, and the cooling cavity 7 is provided with a refrigerant inlet pipe 71 and a refrigerant outlet pipe 72; a filter screen 61 and a funnel-shaped partition plate 62 are sequentially arranged in the crystallization tank 6 from bottom to top, and a second electromagnetic valve 621 is arranged at a leakage opening of the partition plate 62; a plurality of cooling plates 8 which are uniformly arranged are vertically arranged in the crystallization tank 6 above the partition plate 62, and the front side and the rear side of each cooling plate 8 are communicated with the cooling cavity 7; the crystallization tank 6 side wall on one side of the filter screen 61 is provided with a crystal discharge port 63, and the bottom of the crystallization tank 6 is provided with a liquid discharge port 64.

In the technical scheme, a dissolving tank 1, a buffer cavity 4 and a crystallizing tank 6 provide a closed recrystallization environment, camptothecin and a recrystallization solvent respectively enter the dissolving tank 1 through a feeding port 11 and a liquid adding port 12, an electric heating pipe 33 is started to heat water in a heating cavity 3, so that the inside of the dissolving tank 1 is uniformly heated, the dissolving speed of the camptothecin is accelerated, meanwhile, a mixing component 2 is used for stirring and mixing the camptothecin and the recrystallization solvent, the camptothecin and the recrystallization solvent are fully and uniformly mixed to form a recrystallization liquid, the phenomenon that undissolved camptothecin remained in the recrystallization liquid affects the recrystallization effect is avoided, complete recrystallization is guaranteed, and the recrystallization effect is enhanced; wherein the water injection port 31 and the water discharge port 32 realize the discharge and injection of the water body in the heating cavity 3; after the camptothecin is dissolved, the electromagnetic valve I131 is controlled to be opened, the recrystallized liquid flows into the buffer cavity through the liquid outlet pipe 13, and the motor I drives the rotating roller 5 to rotate in the downward flowing process of the recrystallized liquid, so that the dispersing rod 51 is driven to rotate and disperse the recrystallized liquid, the heat dissipation efficiency of the recrystallized liquid is accelerated, the temperature of the recrystallized liquid is reduced, and the subsequent cooling crystallization operation of the crystallization tank 6 is facilitated; the recrystallization liquid falls to the bottom of the buffer cavity 4 and enters the crystallizing tank 6 through the liquid separating pipe 41, and the arrangement of the liquid separating pipe 41 is favorable for uniformly distributing the recrystallization liquid in the crystallizing tank 6; the refrigerant (condensed water, etc.) enters the cooling cavity 7 through the refrigerant inlet pipe 71, the refrigerant liquid in the cooling cavity 7 enters the cooling plate 8 again, and finally the refrigerant liquid is discharged through the refrigerant outlet pipe 72 and continuously circulates; the cooling cavity 7 is matched with the cooling plate 8 together, and the recrystallization liquid in the crystallization tank 6 is uniformly cooled, so that the precipitation and crystallization speed of camptothecin is increased, the recrystallization effect is enhanced, and the processing and production efficiency is improved; after crystallization is finished, the second electromagnetic valve 621 is controlled to be opened, the recrystallized liquid flows out from the leakage opening of the partition plate 62, the precipitated camptothecin crystals are intercepted on the filter screen 61, the recrystallized liquid passes through the filter screen 61 and then is discharged and collected through the liquid discharge opening 64, and the camptothecin crystals on the filter screen 61 are discharged through the crystal discharge opening 63 for subsequent operation.

In another example, the heating tube 33 has a spiral structure. By adopting the scheme, the electric heating pipe 33 with the spiral structure is beneficial to increasing the contact area of the electric heating pipe and the water body, thereby increasing the heating area and improving the heating rate.

In another example, the mixing assembly 2 comprises a second motor 21, a mixing rod 22, a helical blade 23 and a plurality of auxiliary blades 24, the mixing rod 22 is in transmission connection with the second motor 21, and the helical blade 23 and the auxiliary blades 23 are mounted on the mixing rod 22. By adopting the scheme, the mixing rod 22 is driven by the second motor 21 to rotate to drive the spiral blade 23 to rotate, the liquid at the bottom in the dissolving tank 1 is lifted to the top by the spiral blade 23 and then falls down to form vertical mixing, the auxiliary blade 24 is used for transversely mixing the liquid in the rotating process, the dissolving speed of the camptothecin is further accelerated, and the dissolved camptothecin and the recrystallization solvent are fully and uniformly mixed.

In another example, the outer surface of the buffer cavity 4 is provided with a plurality of heat dissipation fins 42; the top of the crystallizing tank 6 is provided with a fan 9 facing the buffer chamber 4. By adopting the scheme, the heat dissipation fins 42 are beneficial to dissipating the heat in the buffer cavity 4 to the external environment, and the cooling effect of the buffer cavity 4 on the recrystallized liquid is enhanced; and the wind formed by the fan 9 blows to the buffer cavity 4 and the heat dissipation fins 42, so that the heat dissipation fins 42 and the air near the buffer cavity 4 flow, and the heat of the surfaces of the heat dissipation fins 42 and the buffer cavity 4 is taken away by the flowing air, thereby being beneficial to further improving the cooling efficiency.

In another example, a plurality of heat dissipation fins 43 are connected between two adjacent heat dissipation fins 42. With this arrangement, the heat sink 43 is beneficial to increasing the heat dissipation area and further improving the cooling rate.

In another example, the dissolving tank 1 is provided at the bottom with a reinforcing column 10, and the bottom of the reinforcing column 10 is fixed on the top surface of the crystallizing tank 6 by a heat insulating plate 101. By adopting the scheme, the reinforcing column 10 enhances the overall stability of the recrystallization device, and the heat insulation plate 101 prevents the heat of the dissolving tank 1 from being conducted to the crystallization tank 6 through the reinforcing column 10 to influence the cooling crystallization operation of the crystallization tank 6.

While the embodiments of the invention have been described above, it is not limited to the applications listed in the description and the embodiments, which are fully applicable in all kinds of fields of application of the invention, and further modifications can be easily made by those skilled in the art without departing from the general concept defined by the claims and their equivalents, and it is therefore not limited to the specific details and illustrations shown and described herein, and it is obvious that various changes and modifications can be made by those skilled in the art without departing from the spirit and scope of the invention.

Claims

1. A recrystallization purification device for camptothecin is characterized by comprising:

the dissolving tank (1) is provided with a feeding port (11) and a liquid filling port (12), and a mixing component (2) is arranged in the dissolving tank; a heating cavity (3) with a water filling port (31) and a water draining port (32) is arranged outside the dissolving tank (1), and a plurality of electric heating pipes (33) are arranged in the heating cavity (3); the bottom of the dissolving tank (1) is communicated with the top of the buffer cavity (4) through a liquid outlet pipe (13), and a first electromagnetic valve (131) is arranged at a pipe orifice at the top of the liquid outlet pipe (13);

a rotating roller (5) driven by a motor I to rotate is arranged in the buffer cavity (4), and a dispersing rod (51) is arranged on the outer surface of the rotating roller (5) in a surrounding manner; the bottom of the buffer cavity (4) is communicated with the top of the crystallizing tank (6) through at least 2 liquid separating pipes (41);

a cooling cavity (7) is arranged outside the crystallization tank (6), and the cooling cavity (7) is provided with a refrigerant inlet pipe (71) and a refrigerant outlet pipe (72); a filter screen (61) and a funnel-shaped partition plate (62) are sequentially arranged in the crystallization tank (6) from bottom to top, and a second electromagnetic valve (621) is arranged at a leakage opening of the partition plate (62); a plurality of cooling plates (8) which are uniformly arranged are vertically arranged in the crystallization tank (6) above the partition plate (62), and the front side and the rear side of each cooling plate (8) are communicated with the cooling cavity (7); be equipped with on the crystallizer (6) lateral wall of filter screen (61) one side and arrange brilliant mouth (63), crystallizer (6) bottom is equipped with drain outlet (64).

2. The device for purifying camptothecin by recrystallization, according to claim 1, wherein the electrical heating tube (33) has a spiral structure.

3. The recrystallization purification device for camptothecin according to claim 1, wherein the mixing component (2) comprises a second motor (21), a mixing rod (22), a helical blade (23) and a plurality of auxiliary blades (24), the mixing rod (22) is in transmission connection with the second motor (21), and the helical blade (23) and the auxiliary blades (24) are installed on the mixing rod (22).

4. The recrystallization purification apparatus for camptothecin according to claim 1, wherein the outer surface of the buffer chamber (4) is provided with a plurality of heat dissipation fins (42); and a fan (9) facing the buffer cavity (4) is installed at the top of the crystallizing tank (6).

5. The apparatus for purifying camptothecin by recrystallization according to claim 4, wherein a plurality of heat dissipation fins (43) are connected between two adjacent heat dissipation fins (42).

6. The recrystallization purification apparatus for camptothecin according to claim 1, wherein the bottom of the dissolving tank (1) is provided with a reinforced column (10), and the bottom of the reinforced column (10) is fixed on the top surface of the crystallizing tank (6) through a heat insulation plate (101).