CN210690595U - Magnetic focusing rapid detection system with elution function - Google Patents
Magnetic focusing rapid detection system with elution function Download PDFInfo
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- CN210690595U CN210690595U CN201920988274.4U CN201920988274U CN210690595U CN 210690595 U CN210690595 U CN 210690595U CN 201920988274 U CN201920988274 U CN 201920988274U CN 210690595 U CN210690595 U CN 210690595U
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Abstract
The utility model discloses a magnetic focusing rapid detection system with elution function, which comprises a base, a detection box and an elution box, wherein the base is provided with a groove with the width same as that of the detection box, and a first magnet and a second magnet are arranged in the groove; test paper is arranged in the detection box; the elution box is internally provided with a vacuole, a nitrocellulose film and absorbent paper; the first magnet is aligned with the development position of the contrast line of the detection test paper, the second magnet is aligned with the development position of the detection line of the detection test paper, the test paper is positioned between the nitrocellulose film and the absorbent paper, and the edge of the test paper is mutually attached to the edge of the nitrocellulose film and the edge of the absorbent paper. The utility model discloses prolonged reaction time, very big improvement detectivity to set up the washing box, simplify the washing operation.
Description
Technical Field
The utility model relates to a quick detecting system.
Background
The background art is provided only to aid understanding of the technical contents and is not prior art.
Flow Immunoassay (LFIA) is a practical, simple, and effective rapid pathogen screening technique. LFIA sensors have been used to detect macroscopic targets with visual signals. Typically, untrained personnel can complete LFIA within 15 minutes. However, one key limitation of LFIA is low sensitivity. For the entire pathogen detection, the limit of detection (LOD) of the conventional LFIA is in the range of 104-106 CFU/mL. To increase the sensitivity of lateral flow immunoassay methods, scientists have proposed fluorescent probe-based detection methods that require additional instrumentation to read the signal and may also require additional manipulation steps such as pre-incubation enrichment and amplification of DNA/RNA extracted from pathogens. Analysis of bacterial indicators such as environmental chemicals that are consumed by intercellular enzymes or viable bacteria has also been used for low frequency based detection to improve sensitivity, but requires a longer detection time. The detection of DNA and proteins by LF was enhanced by horseradish peroxidase (HRP) stimulation, so in our previous work we introduced an enzyme amplification strategy to achieve LOD values of about 100CFU/mL by HRP catalyzed reactions. However, food safety standards are stringent, requiring stringent regulations and monitoring standards. Thus, the requirements for sensor specifications are also stringent, requiring high sensitivity, specificity, rapidity, and simplicity, and the potential for field testing.
One of the main reasons for the poor sensitivity of the LFIA platform is the limited interaction of the probe-labeled pathogen with the capture antibody immobilized in the detection zone due to the low surface reaction rate. Since the flow of the LF strip is based on capillary action, the labeled pathogen is controlled by the material properties, and it is difficult to control the interaction time of the labeled target and the capture antibody. The target has a limited interaction time with the capture probe resulting in a lower proportion of the target being captured. To overcome this critical weakness, scientists have employed an electrophoretic technique, known as Isotophoresis (ITP), which allows for pre-concentration and control of the movement of the target by adjusting the current. By slowing down the movement of the target using ITP to increase the interaction time between elements, the LOD of LFIA systems can be improved. However, additional instrumentation is required to control the current in the strip, failing to meet the simplicity requirements for LFIA. In other aspects, Arben et al (2014) printed wax-column patterns on LF web to take advantage of the pseudo-turbulence effect to reduce flow rate and prolong reaction time. They also used different shaped LF bars to control the flow rate. However, the LOD improved based on these simple strategies does not significantly improve the detection of low concentration targets.
One of the main reasons for the low detection sensitivity of the current LFIA platforms is the limited interaction between the probe-labeled pathogen and the capture antibody immobilized at the detection zone due to the low surface reaction rate. The flow of fluid through the LF band is based on capillary action, and the movement of the probe-labeled pathogen is limited by the material properties, making it difficult to control the time of action of the labeled target with the capture antibody. That is to say the limited interaction time of the target with the capture probe results in a low capture rate of the target. To solve this problem, researchers have used isotachophoresis to slow down the movement of the target by adjusting current enrichment and controlling the movement of the target, thereby increasing the interaction time, but this method requires additional equipment to control the current on the strip, and instead makes the detection operation more complicated. Other attempts to extend the interaction time, such as spraying wax columns on the LF strips, changing the shape of the strips, have been made, but the effect is not significant.
The applicant adopts a magnetic modification mode to increase the interaction time of the target object in the detection area on the strip, realizes a lower detection limit, and is additionally provided with a washing box to simplify the cleaning step. However, no kit which is matched with a magnetic modification target and a washing box to realize rapid detection exists at present.
SUMMERY OF THE UTILITY MODEL
An object of the utility model is to provide an utilize the mode of magnetism decoration to increase the target object detection area's on the strip interaction time to install the washing box additional and simplify the washing step, realize the detection limit quick detecting system than lower.
The utility model discloses a following technical scheme realizes:
a magnetic focusing rapid detection system is characterized in that: the device comprises a base, a detection box and an elution box, wherein the base is provided with a groove matched with the detection box, and a first magnet and a second magnet are arranged in the groove; the detection box comprises a box body and detection test paper, the detection test paper is fixed on the box body, and a developing part of the detection test paper is exposed outside the box body; the elution box is internally provided with a vacuole, a guide plate and absorbent paper which are used for storing washing liquid, and the distance between the guide plate and the absorbent paper is matched with the detection test paper; the first magnet is aligned with the development position of the contrast line of the detection test paper, and the second magnet is aligned with the development position of the detection line of the detection test paper.
When the detection device is used, the detection box is firstly placed in the groove of the base, the bottom surface of the box body of the detection box is attached to the base, the development area of the detection test paper is exposed outside the box body, and the contrast line and the detection line of the detection test paper are respectively aligned to the first magnet and the second magnet; adding sample to the test paper, developing, covering the elution box on the test box, and positioning the test paper between the guide plate and the absorbent paper; the vacuole is broken, and the washing liquid flows outwards from the vacuole along the guide plate and reaches a developing area of the detection test paper for washing; then, the washing liquid is absorbed by the absorbent paper, so that the washing liquid is prevented from leaking or accumulating in the base and the detection box. Thus, the detection and washing work is completed.
The structure of the detection test paper is the same as that of the conventional detection test paper, and the detection test paper comprises a sample adding area and a detection display area, wherein the detection display area comprises a contrast line development part and a detection line development part. The guide plate guides the washing liquid in the vacuole to the detection display area of the test paper, and the absorbent paper absorbs the washing liquid by utilizing the siphon action. When the test strip is used, the detection plate is arranged in the groove of the base, and the washing box is clamped on the detection strip, so that the edges of the test strip are mutually attached to the edges of the guide plate and the water absorption paper. The treated sample is applied to the sample application area and the reaction is awaited. Then pressing the button of the washing box to puncture the vacuole and wait. And then, uniformly dripping the color developing solution into the inspection display area, and reading the result after waiting. The detection display area is internally provided with a magnetic detection reagent, such as magnetic nanoparticles modified with antigens. When the sample is added into the sample adding area, the sample reaches the detection display area through siphonage and reacts with the magnetic detection reagent, and under the action of the magnetic fields of the first magnet and the second magnet, the magnetic nanoparticles are concentrated to the first magnet and the second magnet, so that the reaction time is prolonged, and the reagent and the sample are fully reacted.
Preferably, a first magnet mounting hole and a second magnet mounting hole are formed in the base, the first magnet mounting hole is in close fit with the first magnet, and the second magnet mounting hole is in close fit with the second magnet.
Preferably, the cartridge and the washing cartridge are orthogonal. Thus, the washing operation can be completed only by enabling the developing area of the detection box and the washing area of the washing box to be superposed. Particularly, the area between the first surface cover and the bottom cover of the detection box just accommodates the guide plate and the absorbent paper of the washing box, and the area between the guide plate and the absorbent paper just detects the test paper, so that the matching of the washing box and the detection box is completed.
Detection box
The detection box provides detection test paper, two ends of the detection test paper are located in the box body, and the development area of the detection test paper is exposed out of the box body. The exposure means that the development area of the test strip is not covered by the cover sheet but supported only by the bottom cover.
Preferably, the detection box comprises a first surface cover, a second surface cover and a bottom cover, the first surface cover and the bottom cover fix the first ends of the detection test paper, and the second surface cover and the bottom cover fix the second ends of the detection test paper; the developing area of the test paper is exposed between the first cover and the second cover, and the distance between the first cover and the second cover is matched with the washing box. That is, the absorbent paper and the guide plate of the washing box can be placed between the first face cover and the second face cover, so that the washing function is realized.
Preferably, the bottom cover of the detection box is provided with a first magnet positioning hole and a second magnet positioning hole, the first magnet positioning hole is aligned with the development position of the contrast line of the detection test paper, and the second magnet positioning hole is aligned with the development position of the detection line of the detection test paper. Wherein para-position means
Therefore, when the detection box is arranged on the base, the magnet is inserted into the corresponding magnet positioning hole, and the positioning between the detection box and the base can be completed. Of course, other positioning modes can be adopted to realize the correspondence between the magnet and the reference line and the detection line. For example, the base and the detection box are both provided with corresponding mark lines, and when the mark lines are aligned, the magnet corresponds to the comparison line and the detection line.
Preferably, the bottom cover and the first face cover, the second face cover passes through a connecting column and an assembling column, assembling holes are formed in the assembling column, and the connecting column corresponds to the assembling holes one by one and is matched with the assembling holes in a plug-in mode; the connecting column is positioned on the bottom cover, and the assembling column is positioned on the first surface cover and the second surface cover; or the connecting column is positioned on the first surface cover, the second surface cover and the assembling column is positioned on the bottom cover.
Preferably, the first face cover is provided with a sample adding hole, and the sample adding hole corresponds to the sample adding area of the detection test paper. The sample reaches the sample adding area of the detection test paper from the sample adding hole.
Washing box
The purpose of the washing cartridge is to be able to mate with the cartridge and release the washing solution. The washing box provides washing liquid, and the washing liquid washes the test paper.
As a preferred scheme, the washing box comprises a first elution bottom cover, a second elution bottom cover and an elution surface cover, wherein a guide plate is arranged between the elution surface cover and the first elution bottom cover; and water absorption paper is arranged between the elution surface cover and the second elution bottom cover. The washing liquid in the washing chamber flows out to the guide plate, and the guide plate guides the washing liquid to the development position of the detection test paper. The paper that absorbs water absorbs development department washing liquid through the siphon effect for washing liquid can realize flowing in detection demonstration department.
Preferably, a cavity for containing the vacuole is arranged between the first elution bottom cover and the elution surface cover, the first elution bottom cover is provided with a button, and the button is provided with a puncturing piece capable of puncturing the vacuole. The piercing member is a point or edge, or a blunting block. When the washing machine does not work, the distance is reserved between the puncturing piece and the vacuole, and the puncturing piece is not contacted with the vacuole and does not release the washing liquid; when washing, the button is pressed, and the puncturing piece can break the vacuole under the action of pressure to release the washing liquid.
Preferably, the vacuole is positioned between the first elution bottom cover and the flow guide plate, a flow guide channel is arranged between the flow guide plate and the first elution bottom cover, and the flow guide channel is communicated with the cavity. After the vacuole is broken, the liquid flows out from the guide plate through the guide channel.
Preferably, the flow guide plate comprises an inner hidden part positioned between the first elution bottom cover and the elution surface cover and an outer exposed part positioned outside the area of the first elution bottom cover, the flow guide channel is positioned in the inner hidden part, and the area outside the flow guide channel at the inner hidden part is connected with the first elution bottom cover in a sealing way; the flow guide passage has an outlet connected to the exposed portion. So, can all restrict in vacuole and water conservancy diversion passageway with washing liquid, avoid the washing liquid random flow everywhere.
Preferably, the deflector is a glass fiber plate, or a resin plate, or a metal plate, or a plastic plate. The baffle is not limited to the above examples as long as it is a sheet that does not absorb water. The sealing of the baffle to the first elution bottom cap includes, but is not limited to: sealant is arranged between the guide plate and the first elution bottom cover; or a sealing gasket.
Preferably, the first elution bottom plate is provided with a groove, the groove forms a top plate and two side plates of the flow guide channel, the flow guide plate forms a bottom plate of the flow guide channel, and the flow guide plate is a flat plate. Or the guide plate is provided with a groove, the groove of the guide plate forms a bottom plate and two side plates of the guide channel, and the first elution bottom plate forms a top plate of the guide channel. Or the guide plate is provided with a first groove, the first elution bottom plate is provided with a second groove, the first groove is aligned to the second groove, and the first groove and the second groove are spliced to form a guide channel.
The washing box can realize accurate quantification of the washing liquid, accurately guide the washing liquid to a developing area of the detection test paper, absorb the washing liquid after washing, and avoid retention of the washing liquid; the whole detection and washing process is convenient and clean.
The utility model has the advantages that:
1. the external magnet serves to slow the movement of the labeled target pathogen in the LFIA strip detection zone, thereby prolonging the reaction time.
2. The HRP signal amplification and magnetic region control technology are combined, so that the detection sensitivity is greatly improved, and detection signals visible to naked eyes can be obtained almost by single cell level detection.
3. The method has the advantages of high pathogen detection speed, short period, simple operation, no need of using additional equipment and no need of performing pre-culture operation.
4. The washing box is arranged, so that the washing operation is simplified, and no washing liquid is retained after washing is finished.
Drawings
Fig. 1 is a front view of the washing box of the present invention.
FIG. 2 is a reverse side view of the washing box of the present invention
Fig. 3 is a schematic view of the reverse side of the detection board of the present invention.
Fig. 4 is a front schematic view of the detection board of the present invention.
Fig. 5 is an exploded view of the detection board of the present invention.
Fig. 6 is a schematic view of the base of the present invention.
Fig. 7 is a schematic diagram of the detection result of the present invention.
1 in the attached drawings: a baffle; 2: a button; 3: a washing chamber; 4: an elution surface cover; 5: a first elution bottom cap; 6: a second elution bottom cap; 7: absorbent paper; 8: a piercing member; 9: a sample application hole; 10: a first face cover; 11: a second face cover; 12: a bottom cover; 13: detecting test paper; 13A, detecting line development; 13B, contrast line development; 14: a first magnet positioning hole; 15: a second magnet positioning hole; 16: connecting columns; 17: assembling the column; 18 a second magnet mounting hole; 19: a first magnet mounting hole;
Detailed Description
A magnetic focusing rapid detection system is characterized in that: the device comprises a base, a detection box and an elution box, wherein the base is provided with a groove matched with the detection box, and a first magnet and a second magnet are arranged in the groove; the detection box comprises a box body and detection test paper 13, wherein the detection test paper 13 is fixed on the box body, and a developing part of the detection test paper 13 is exposed outside the box body; the elution box is internally provided with a vacuole, a guide plate 1 and absorbent paper 7 which are used for storing washing liquid, and the distance between the guide plate 1 and the absorbent paper 7 is matched with the detection test paper 13; the first magnet is aligned with the contrast line development site 13B of the test strip 13, and the second magnet is aligned with the detection line development site 13A of the test strip 13.
When the detection device is used, the detection box is firstly placed in the groove of the base, the bottom surface of the box body of the detection box is attached to the base, the development area of the detection test paper 13 is exposed outside the box body, and the contrast line and the detection line of the detection test paper 13 are respectively aligned to the first magnet and the second magnet; adding sample to the test paper 13, after developing, covering the elution box on the test box, wherein the test paper 13 is positioned between the guide plate 1 and the absorbent paper 7; the vacuole is broken, and the washing liquid flows outwards along the guide plate 1 from the vacuole and reaches a developing area of the detection test paper 13 for washing; then, the washing liquid is absorbed by the absorbent paper 7, and the washing liquid is prevented from leaking or accumulating in the chassis or the detection box. Thus, the detection and washing work is completed.
The test strip 13 has the same structure as the conventional test strip 13, and includes a sample application region and a detection display region, and the detection display region includes a contrast line development portion 13B and a detection line development portion 13A. The guide plate 1 guides the washing liquid in the vacuole to a detection display area of the test paper, and the absorbent paper 7 absorbs the washing liquid by utilizing the siphon action. When the test paper is used, the detection plate is arranged in the groove of the base, the washing box is clamped on the detection strip, and the edge of the test paper is mutually attached to the edge of the guide plate 1 and the edge of the absorbent paper 7. The treated sample is applied to the sample application area and the reaction is awaited. Then pressing the button 2 of the washing box punctures the vacuole and waits. And then, uniformly dripping the color developing solution into the inspection display area, and reading the result after waiting. The detection display area is internally provided with a magnetic detection reagent, such as magnetic nanoparticles modified with antigens. When the sample is added into the sample adding area, the sample reaches the detection display area through siphonage and reacts with the magnetic detection reagent, and under the action of the magnetic fields of the first magnet and the second magnet, the magnetic nanoparticles are concentrated to the first magnet and the second magnet, so that the reaction time is prolonged, and the reagent and the sample are fully reacted.
Preferably, a first magnet mounting hole 19 and a second magnet mounting hole 18 are formed in the base, the first magnet mounting hole 19 is in close fit with the first magnet, and the second magnet mounting hole 18 is in close fit with the second magnet.
Preferably, the cartridge and the washing cartridge are orthogonal. Thus, the washing operation can be completed only by enabling the developing area of the detection box and the washing area of the washing box to be superposed. Specifically, the area between the first surface cover 10 and the bottom cover 12 of the detection box just accommodates the guide plate 1 and the absorbent paper 7 of the washing box, and the area between the guide plate 1 and the absorbent paper 7 just detects the test paper 13, so that the matching of the washing box and the detection box is completed.
Detection box
The detection box provides a detection test paper 13, two ends of the detection test paper 13 are positioned in the box body, and a development area of the detection test paper 13 is exposed out of the box body. The exposure means that the development area of the test strip 13 is not covered by the cover sheet, but is supported only by the bottom cover 12.
Preferably, the test cassette comprises a first face cover 10, a second face cover 11 and a bottom cover 12, wherein the first face cover 10 and the bottom cover 12 fix a first end of the test strip 13, and the second face cover 11 and the bottom cover 12 fix a second end of the test strip 13; the developed area of the test strip 13 is exposed between the first and second covers 10 and 11, and the distance between the first and second covers 10 and 11 is adapted to the washing box. That is, the absorbent paper 7 and the baffle 1 of the washing box can be put between the first cover 10 and the second cover 11 to realize the washing function.
Preferably, the bottom cover 12 of the test cassette is provided with a first magnet positioning hole 14 and a second magnet positioning hole 15, the first magnet positioning hole 14 is aligned with the contrast line development site 13B of the test strip 13, and the second magnet positioning hole 15 is aligned with the detection line development site 13A of the test strip 13. Therefore, when the detection box is arranged on the base, the magnet is inserted into the corresponding magnet positioning hole, and the positioning between the detection box and the base can be completed. Of course, other positioning modes can be adopted to realize the correspondence between the magnet and the reference line and the detection line. For example, the base and the detection box are both provided with corresponding mark lines, and when the mark lines are aligned, the magnet corresponds to the comparison line and the detection line.
Preferably, the bottom cover 12 is connected with the first face cover 10, the second face cover 11 is connected with the assembling column 17 through the connecting column 16, assembling holes are formed in the assembling column 17, and the connecting columns 16 correspond to the assembling holes one by one and are matched in a plug-in mode; the connecting column 16 is positioned on the bottom cover 12, the assembling column 17 is positioned on the first face cover 10 and the second face cover 11; alternatively, the connecting column 16 is located on the first cover 10, the second cover 11, and the assembling column 17 is located on the bottom cover 12.
Preferably, the first cover 10 is provided with a sample adding hole 9, and the sample adding hole 9 corresponds to a sample adding area of the test paper 13. The sample reaches the application area of the test strip 13 from the application hole 9.
Washing box
The purpose of the washing cartridge is to be able to mate with the cartridge and release the washing solution. The washing box provides a washing solution, and the washing solution washes the test paper 13.
Preferably, the washing box comprises a first elution bottom cover 5, a second elution bottom cover 6 and an elution surface cover 4, and a flow guide plate 1 is arranged between the elution surface cover 4 and the first elution bottom cover 5; and water absorption paper 7 is arranged between the elution surface cover 4 and the second elution bottom cover 6. The washing liquid in the washing chamber 3 flows out to the guide plate 1, and the guide plate 1 guides the washing liquid to the development position of the detection test paper 13. The absorbent paper 7 absorbs the cleaning solution at the developing position through the siphon action, so that the cleaning solution can flow at the detection display position.
Preferably, a cavity for containing the vacuole is arranged between the first elution bottom cover 5 and the elution surface cover 4, the first elution bottom cover 5 is provided with a button 2, and the button 2 is provided with a puncturing piece 8 capable of puncturing the vacuole. Wherein the vacuole accommodating chamber is the washing chamber 3. The piercing member 8 is a point or edge, or a blunting block. When the device does not work, the puncturing piece 8 is away from the vacuole, and the puncturing piece 8 does not contact the vacuole and can not release the washing liquid; when washing, the button 2 is pressed, and the puncture piece 8 can break the vacuole under the action of pressure to release the washing liquid. Preferably, the vacuole is located between the first elution bottom cover 5 and the guide plate 1, a flow guide channel is arranged between the guide plate 1 and the first elution bottom cover 5, and the flow guide channel is communicated with the vacuole accommodating cavity. After the vacuole is broken, the liquid flows out of the guide plate 1 through the guide channel.
Preferably, the flow guide plate 1 comprises an inner hidden part positioned between the first elution bottom cover 5 and the elution surface cover 4 and an outer exposed part positioned outside the area of the first elution bottom cover 5, the flow guide channel is positioned in the inner hidden part, and the area outside the flow guide channel at the inner hidden part is hermetically connected with the first elution bottom cover 5; the flow guide passage has an outlet connected to the exposed portion. So, can all restrict in vacuole and water conservancy diversion passageway with washing liquid, avoid the washing liquid random flow everywhere.
Preferably, the deflector 1 is a glass fiber plate, or a resin plate, or a metal plate, or a plastic plate. The baffle 1 is not limited to the above examples as long as it is a sheet that does not absorb water. The sealing means of the baffle 1 to the first elution bottom cap 5 include, but are not limited to: sealant is arranged between the guide plate 1 and the first elution bottom cover 5; or a sealing gasket.
Preferably, the first elution bottom plate is provided with a groove, the groove forms a top plate and two side plates of the flow guide channel, the flow guide plate 1 forms a bottom plate of the flow guide channel, and the flow guide plate 1 is a flat plate. Or the guide plate 1 is provided with a groove, the groove of the guide plate 1 forms a bottom plate and two side plates of the guide channel, and the first elution bottom plate forms a top plate of the guide channel. Or, the guide plate 1 is provided with a first groove, a second groove is formed on the first elution bottom plate, the first groove is aligned to the second groove, and the first groove and the second groove are spliced to form a guide channel.
A method of use of the magnetic focus rapid detection system is now described.
Taking 25g mL of sample, crushing, adding into 225mL of liquid culture medium, homogenizing, mixing uniformly, and culturing at 36 +/-1 ℃ for 5-6 h. About 100. mu.L of the treated sample was added to the well 9 and allowed to wait for 10 minutes. Press button 28 on the washing box and wait 10 minutes. The washing box was removed, 100. mu.L of the developing solution was dropped uniformly into the inspection window, and the results were read after 15 minutes. As shown in FIG. 5, the C and T lines showed positive reaction when they all appeared, the C line showed color, the T line showed negative reaction when it did not appear, the C line did not appear, the test failed or the test card failed, and the results read after more than 30 minutes were all invalid.
Claims (9)
1. A magnetic focusing rapid detection system with elution function is characterized in that: the washing machine comprises a base, a detection box and a washing box, wherein the base is provided with a groove matched with the detection box, and a first magnet and a second magnet are arranged in the groove; the detection box comprises a box body and detection test paper, the detection test paper is fixed on the box body, and a developing part of the detection test paper is exposed outside the box body; the washing box is internally provided with a vacuole, a guide plate and absorbent paper which are used for storing washing liquid, and the distance between the guide plate and the absorbent paper is matched with the detection test paper; the first magnet is aligned with the development position of the contrast line of the detection test paper, and the second magnet is aligned with the development position of the detection line of the detection test paper.
2. A magnetic focusing rapid detection system with elution function as claimed in claim 1, wherein: the groove is internally provided with a first magnet mounting hole and a second magnet mounting hole, the first magnet mounting hole is tightly matched with the first magnet, and the second magnet mounting hole is tightly matched with the second magnet.
3. A magnetic focusing rapid detection system with elution function as claimed in claim 1, wherein: the detection box and the washing box are orthogonal.
4. A magnetic focusing rapid detection system with elution function as claimed in claim 1, wherein: the detection box comprises a first face cover, a second face cover and a bottom cover, the detection test paper is arranged in the first face cover, a test paper groove between the second face cover and the bottom cover, the middle part of the test paper is exposed, and a distance is arranged between the first face cover and the second face cover and is in clearance fit with the washing box.
5. A magnetic focusing rapid detection system with elution function as claimed in claim 4, characterized in that: the bottom cover and the first face cover, the second face cover is connected with the assembling column through a connecting column, the assembling column is provided with assembling holes, and the connecting column and the assembling holes are in one-to-one correspondence and are in plug-in type matching; the connecting column is positioned at the bottom cover, and the assembling column is positioned at the surface cover; or the connecting column is positioned on the surface cover, and the assembling column is positioned on the bottom cover.
6. The magnetic focusing rapid detection system with elution function as claimed in claim 5, wherein: the first face cover is provided with a sample adding hole, and the sample adding hole corresponds to a sample adding area of the detection test paper.
7. A magnetic focusing rapid detection system with elution function as claimed in claim 1, wherein: the washing box comprises a first elution bottom cover, a second elution bottom cover and an elution surface cover, and a guide plate is arranged between the elution surface cover and the second elution bottom cover.
8. A magnetic focusing rapid detection system with elution function as claimed in claim 7, wherein: and water absorption paper is arranged between the elution surface cover and the second elution bottom cover.
9. A magnetic focusing rapid detection system with elution function as claimed in claim 7, wherein: the first elution bottom cover is provided with a button, and the button is provided with a puncture piece.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201920974882 | 2019-06-26 | ||
| CN201920974882X | 2019-06-26 |
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| Publication Number | Publication Date |
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| CN210690595U true CN210690595U (en) | 2020-06-05 |
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| CN201920988274.4U Expired - Fee Related CN210690595U (en) | 2019-06-26 | 2019-06-28 | Magnetic focusing rapid detection system with elution function |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110333345A (en) * | 2019-06-28 | 2019-10-15 | 浙江大学山东工业技术研究院 | A kind of magnetic focusing rapid detection system with elution function |
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2019
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110333345A (en) * | 2019-06-28 | 2019-10-15 | 浙江大学山东工业技术研究院 | A kind of magnetic focusing rapid detection system with elution function |
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