CN210642282U - Solid powder sterilizing equipment - Google Patents
Solid powder sterilizing equipment Download PDFInfo
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- CN210642282U CN210642282U CN201920950544.2U CN201920950544U CN210642282U CN 210642282 U CN210642282 U CN 210642282U CN 201920950544 U CN201920950544 U CN 201920950544U CN 210642282 U CN210642282 U CN 210642282U
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Abstract
The utility model relates to a solid powder sterilization equipment device. The equipment consists of a sterilization tank A, a buffer tank B, a sterilizing agent generating tank C and an aseptic gas generating tank D; a sterilization tank body A1 is fixedly connected with a rotating shaft A3, the rotating shaft A3 is supported on a supporting frame E through a bearing, a feed/discharge port A2 is positioned above and below the sterilization tank body A1, a sterilization gas interface A5 is positioned on the sterilization tank body A1 and is communicated with a sterilization steam outlet C4 through a pipeline with a valve, a buffer tank interface A6 is positioned on the sterilization tank body A1 and is communicated with a sterilization tank interface B3 through a pipeline with a valve, an aseptic gas interface A7 is positioned on the sterilization tank body A1 and is communicated with a sterilization tank interface D4 through a pipeline with a valve, and a vacuum nozzle A8 is externally connected to a vacuum pumping device through a pipeline with a valve. The equipment effectively solves the problems of material denaturation, harm of residual substances to bodies and the like caused by high-temperature sterilization.
Description
Technical Field
The utility model relates to a medicine food production facility field, concretely relates to solid powder sterilization equipment device.
Background
With the development of the health industry, people have higher and higher requirements on the sanitation of medicines, foods and the like, and correspondingly, the requirements on sterilization equipment are higher and higher, so that the sterilization requirements are met, and the characteristics of medicines cannot be damaged during sterilization. The currently used powder sterilization methods mainly include dry heat sterilization method or wet heat sterilization method, chemical sterilization method and60co-gamma ray radiation sterilization method.
Dry heat or wet heat sterilization method is easy to cause material change for some heat-labile substancesAnd (4) influence the final quality of the material. In addition, the dry heat sterilization method has poor heat penetration force, so in order to ensure the sterilization effect, the sterilization time is generally longer, and the sterilization temperature is also higher; the moist heat sterilization method has the advantages of high latent heat of steam, strong penetrating power and lower temperature than the dry heat sterilization method, but the moist heat sterilization method also has the advantages that substances sensitive to heat are easy to denature or solidify, and the materials are denatured. A large amount of substances such as sodium benzoate and the like are generally added in a chemical sterilization method, and although the antibacterial and sterilization effects are achieved, new substances are introduced into materials, so that new potential safety hazards and risks are brought to products, and the natural and healthy idea is not met;60the Co-gamma ray irradiation sterilization method is simple and cheap to operate, but partial substance denaturation can be caused by the rays, and meanwhile, irradiation also has residues, so that the safety risk is brought to the use of products.
Based on the facts, an equipment device capable of overcoming the sterilization defect in the existing powder material production process is urgently needed in the production process of medicines and foods: microorganisms can be killed at a lower temperature, and the denaturation of materials caused by high temperature is reduced; the sterilizing agent is safe, and the safety problem caused by the residual sterilizing agent is avoided; sterilization has no dead angle and is complete; the sterilization mode is safe, and the risks of powder explosion and the like can not be caused; simple operation and low cost.
Disclosure of Invention
An object of the utility model is to provide a solid powder sterilizing installation with sterilization temperature is low, safe.
The solid powder sterilization equipment of the utility model consists of a sterilization tank A, a buffer tank B, a sterilizing agent generating tank C and an aseptic gas generating tank D; the sterilization tank A comprises a sterilization tank body A1, a material inlet/outlet A2, a rotating shaft A3, a sterilization gas interface A5, a buffer tank interface A6, a sterile gas interface A7 and a vacuum nozzle A8; the buffer tank B comprises a buffer tank body B1, a first sterilization tank interface B3, a vacuum interface B4 and a first pressure relief port B5; the sterilizing agent generating tank C comprises a sterilizing agent generating tank body C1, a sterilizing agent feeding hole C3, a sterilizing steam outlet C4 and a pressure relief hole II C5; the sterile gas generating tank D comprises a sterile gas tank body D1, a sterile gas inlet D3, a second sterilizing tank connector D4 and a third pressure relief port D5; a sterilization tank body A1 is fixedly connected with a rotating shaft A3, the rotating shaft A3 is supported on a supporting frame E through a bearing, a feed/discharge port A2 is positioned above and below the sterilization tank body A1, a sterilization gas interface A5 is positioned on the sterilization tank body A1 and is communicated with a sterilization steam outlet C4 through a pipeline with a valve, a buffer tank interface A6 is positioned on the sterilization tank body A1 and is communicated with a sterilization tank interface B3 through a pipeline with a valve, an aseptic gas interface A7 is positioned on the sterilization tank body A1 and is communicated with a sterilization tank interface D4 through a pipeline with a valve, and a vacuum nozzle A8 is externally connected to a vacuum pumping device through a pipeline with a valve.
The sterilizing tank A, the buffer tank B, the sterilizing agent evaporating tank C and the sterile gas tank D are respectively provided with a heating interlayer for adjusting the temperature in the tanks.
The sterilizing tank A, the buffer tank B, the sterilizing agent evaporating tank C and the sterile gas tank D are respectively provided with a temperature/pressure gauge for displaying the temperature and the pressure in the tanks.
The sterilizing agent used by the equipment can be water, ethanol, ethyl acetate, n-hexane, cyclohexane, air, nitrogen, oxygen and carbon dioxide, the sterilizing agent is preferably water for heat-insensitive materials, and the sterilizing agent is preferably ethanol and ethyl acetate for heat sensitivity.
The interlayer heating mode of the device can be water, steam, electricity and heat conducting oil. The heating may be carried out by using a sandwich or by using other techniques known in the art.
The aseptic gas used in the aseptic gas tank can be air, oxygen, nitrogen or carbon dioxide.
The basic flow of the operation of the equipment is as follows:
1. feeding material
Adding the solid powder material into A1 through A2; opening a valve on A8, and vacuumizing; a4 is turned on and heated to a predetermined temperature.
2. Sterilization
A sterilizing agent is added through C3 on the sterilizing agent generating tank C; c2 is opened to heat to a preset temperature to generate sterilizing steam; opening a valve on an A5 pipeline on the sterilization tank A, communicating the A5 with the C4, and putting sterilization gas; the rotating shaft A3 drives the materials in the sterilization tank A1 to rotate for sterilization. After sterilization was complete, a5 and C4 were turned off.
3. Sterilant replacement
Opening a valve on B4 on the buffer tank B, and vacuumizing; opening a valve to communicate A6 and B3, enabling the sterilizing agent in A1 to enter B1, enabling the sterilizing agent to be condensed into liquid in a buffer tank (through interlayer cooling liquid) or opening B4 to be directly pumped away, and closing A6 and B3; opening D3, and opening D2 to make the temperature of the sterile gas consistent with that in A1; opening a valve to communicate D4 and A7, and introducing sterile gas into A1 to replace a sterilizing agent; rotating the rotating shaft A3 to fully displace the sterilizing agent; the valves were opened to connect a6 and B3 and sterilant gas was admitted to B1 and this was repeated several times until the sterilant in a1 was completely displaced.
4. Discharging
Stopping heating the interlayer of the A, D tank, and returning to normal temperature; a1, adding sterile gas until the internal pressure is consistent with the atmospheric pressure outside the tank; opening the discharge port A2 of A1, and discharging the materials.
The beneficial effects of the utility model reside in that: (1) the sterilizing steam can be put in through the high vacuum of the sterilizing space, the concentration of the sterilizing agent is increased, and the quick sterilizing effect is achieved; (2) the device leads the sterilizing agent to be completely gasified and to fill the space of the sterilizing tank, and simultaneously leads the sterilization to be uniform and sufficient without dead angles through the rotation of the sterilizing tank; (3) the temperature in the sterilization process can be adjusted by controlling the vacuum degree, and the sterilization process is suitable for the sterilization of heat-sensitive substances; (4) the sterilization process is in a completely sealed state, so that the phenomena of moisture absorption, caking and the like of materials are avoided; (5) when the device is used, the contact between the materials and air can be avoided, and the materials can be protected by inert gas, so that the materials are prevented from being oxidized and denatured; (6) the device can combine the mixing and sterilization processes of materials into one, reduces the working procedures, saves the cost and is particularly suitable for the production of pharmaceutical factories, food factories and health-care food factories. Effectively solves the problems of material denaturation, harm to human bodies by residual substances, explosion danger in powder sterilization production and the like caused by high-temperature sterilization.
The utility model discloses an in the airtight space in vacuum, use the germicide gasification such as ethanol, greatly increase the permeability of germicide, the microorganism is killed out completely at no dead angle, gaseous replacement such as the aseptic nitrogen gas of rethread and dilution germicide. Effectively solves the problems of material denaturation, harm to human bodies by residual substances, possible explosion and other dangers in the sterilization process caused by high-temperature sterilization. The sterilization method is particularly suitable for sterilizing products containing heat-sensitive active substances such as leeches and the like and freeze-dried pseudo-ginseng and the like which need to keep fresh active substances, and has the advantages of high sterilization effect, safety, low cost and the like.
Drawings
Fig. 1 is a schematic structural diagram of the present invention.
In the figure: a-a sterilization tank, A1-a sterilization tank body, A2-a material inlet/outlet, A3-a rotating shaft, A4-a first heating interlayer, A5-a sterilization gas interface, A6-a buffer tank interface, A7-a sterile gas interface, A8-a vacuum pipe orifice, and A9-a first temperature/pressure gauge; b-a buffer tank, B1-a buffer tank body, B2-a heating interlayer II, B3-a sterilizing tank interface I, B4-a vacuum interface, B5-a pressure relief port I and B6-a temperature/pressure gauge II; c-a sterilizing agent generating tank, C1-a sterilizing agent generating tank body, C2-a heating interlayer III, C3-a sterilizing agent feeding port, C4-a sterilizing steam outlet, C5-a pressure relief port II and C6-a temperature/pressure meter III; d-sterile gas generating tank, D1-sterile gas tank, D2-heating interlayer four, D3-sterile gas inlet, D4-sterilizing tank connector two, D5-pressure relief opening three and D6-temperature/pressure gauge four.
Detailed Description
The following description is of the preferred embodiments of the present invention and is not intended to limit the invention.
Example (b):
the solid powder sterilization equipment comprises a sterilization tank A, a buffer tank B, a sterilizing agent evaporation tank C and a sterile gas tank D; the sterilization tank A comprises a sterilization tank body A1, a material inlet/outlet A2, a rotating shaft A3, a sterilization gas interface A5, a buffer tank interface A6, a sterile gas interface A7 and a vacuum nozzle A8; the sterilization pot A is provided with a heating interlayer A4 and a temperature/pressure gauge A9. The sterilization tank body A1 is fixedly connected with a rotating shaft A3, the rotating shaft A3 is supported on a supporting frame E through a bearing, and the material inlet/outlet A2 is positioned above and below the sterilization tank body A1. The vacuum nozzle A8 is externally connected to a vacuum pumping device through a pipe with a valve.
The buffer tank B comprises a buffer tank body B1, a first sterilization tank interface B3, a vacuum interface B4 and a first pressure relief port B5; the buffer tank B is provided with a second heating interlayer B2 and a second temperature/pressure gauge B6.
The sterilizing agent generating tank C comprises a sterilizing agent generating tank body C1, a sterilizing agent feeding hole C3, a sterilizing steam outlet C4 and a pressure relief hole C5 II; sterilant generator C has heating jacket three C2 and temperature/pressure gauge three C6.
The sterile gas tank generating tank D comprises a sterile gas tank body D1, a sterile gas inlet D3, a second sterilizing tank connector D4 and a third pressure relief port D5; the sterile gas tank generator tank D has a heating sandwich layer four D2 and a temperature/pressure gauge four D6.
The A5 and the C4 are communicated by a pipeline with a valve, the A6 and the B3 are communicated by a pipeline with a valve, the A7 and the D4 are communicated by a pipeline with a valve,
the working steps are as follows:
(1) 50 kg of pseudo-ginseng powder (80 meshes) is taken and added into a 200L sterilization tank A1, A8 is opened, vacuum pumping is carried out till-0.08 mm Hg, A4 is opened, and the temperature is set at 80 ℃.
(2) Opening C3, adding 90% ethanol 5L, opening C2, adjusting temperature in C1 to 80 deg.C, vaporizing sterilizing agent to generate sterilizing steam.
Connecting the C4 interface with the A5 interface to enable the sterilant vapor in the C1 to enter the A1 interface; rotating the rotating shaft a3 for about 60 minutes; after sterilization was complete, a5 and C4 were turned off.
(3) B4 was opened, vacuum was applied to-0.08 mmHg to connect A6 and B3, allowing the gas in A1 to enter B1 and the sterilant vapor was removed.
(4) Opening D3, introducing sterile air, opening D2, heating D1 to 80 ℃, communicating the interface of D4 and A7, introducing sterile air into A1, and rotating the rotating shaft A3 for about 10 minutes. Repeating the operation process (3) to continuously replace and release the sterilizing agent by the sterile air.
(5) Repeating the steps (3) and (4) until the gas released from the buffer tank has no alcohol smell.
(6) Opening B5, communicating the sterilizing tank with the buffer tank to make the air pressure in the sterilizing tank consistent with the air pressure outside the tank, opening A2, discharging Notoginseng radix powder, and packaging.
(7) The detection is carried out according to a microbiological detection method specified in Chinese pharmacopoeia, and the detection accords with the specification.
(8) And (3) detecting the ethanol residue of the sterilized pseudo-ginseng powder, wherein the ethanol residue is 0.083%, and the ethanol residue accords with relevant regulations of medicines, foods, health care products and cosmetics.
The above description is the preferred embodiment of the present invention, and should not be used to limit the present invention, it should be noted that: for those skilled in the art, without departing from the principle of the present invention, several modifications and equivalents may be made, and such modifications and equivalents should be considered as the protection scope of the present invention.
Claims (3)
1. A solid powder sterilization device is characterized by comprising a sterilization tank (A), a buffer tank (B), a sterilizing agent generating tank (C) and an aseptic gas generating tank (D); the sterilization tank (A) comprises a sterilization tank body (A1), a material inlet/outlet (A2), a rotating shaft (A3), a sterilization gas interface (A5), a buffer tank interface (A6), a sterile gas interface (A7) and a vacuum pipe orifice (A8); the buffer tank (B) comprises a buffer tank body (B1), a first sterilization tank interface (B3), a vacuum interface (B4) and a first pressure relief port (B5); the sterilizing agent generating tank (C) comprises a sterilizing agent generating tank body (C1), a sterilizing agent feeding hole (C3), a sterilizing steam outlet (C4) and a pressure relief hole II (C5); the sterile gas generating tank (D) comprises a sterile gas tank body (D1), a sterile gas inlet (D3), a second sterilizing tank connector (D4) and a third pressure relief port (D5); the sterilization tank body (A1) is fixedly connected with the rotating shaft (A3), the rotating shaft (A3) is supported on a support frame E through a bearing, the material inlet/outlet port (A2) is positioned above and below the sterilization tank body (A1), the sterilization gas interface (A5) is positioned on the sterilization tank body (A1) and is communicated with the sterilization steam outlet (C4) through a pipeline with a valve, the buffer tank interface (A6) is positioned on the sterilization tank body (A1) and is communicated with the sterilization tank interface I (B3) through a pipeline with a valve, the sterile gas interface (A7) is positioned on the sterilization tank body (A1) and is communicated with the sterilization tank interface II (D4) through a pipeline with a valve, and the vacuum nozzle (A8) is externally connected to a vacuum pumping device through a pipeline with a valve.
2. The apparatus for sterilizing solid powder according to claim 1, wherein the sterilizing tank (a), the buffer tank (B), the sterilizing agent generating tank (C) and the sterile gas generating tank (D) are each provided with a heating jacket.
3. The apparatus for sterilizing solid powders according to claim 1, wherein the sterilizing tank (a), the buffer tank (B), the sterilizing agent generating tank (C) and the sterile gas generating tank (D) are each provided with a temperature/pressure gauge, respectively.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201920950544.2U CN210642282U (en) | 2019-06-24 | 2019-06-24 | Solid powder sterilizing equipment |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201920950544.2U CN210642282U (en) | 2019-06-24 | 2019-06-24 | Solid powder sterilizing equipment |
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| Publication Number | Publication Date |
|---|---|
| CN210642282U true CN210642282U (en) | 2020-06-02 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201920950544.2U Expired - Fee Related CN210642282U (en) | 2019-06-24 | 2019-06-24 | Solid powder sterilizing equipment |
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| CN (1) | CN210642282U (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN115463233A (en) * | 2022-10-20 | 2022-12-13 | 云南中医药大学 | Sterilizing method of fel powder |
| CN115554440A (en) * | 2022-10-20 | 2023-01-03 | 云南中医药大学 | Isatis root powder sterilization device and method |
-
2019
- 2019-06-24 CN CN201920950544.2U patent/CN210642282U/en not_active Expired - Fee Related
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN115463233A (en) * | 2022-10-20 | 2022-12-13 | 云南中医药大学 | Sterilizing method of fel powder |
| CN115554440A (en) * | 2022-10-20 | 2023-01-03 | 云南中医药大学 | Isatis root powder sterilization device and method |
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| Date | Code | Title | Description |
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| GR01 | Patent grant | ||
| GR01 | Patent grant | ||
| CF01 | Termination of patent right due to non-payment of annual fee | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20200602 Termination date: 20210624 |