CN210487580U - Combined centrifugal disc and analysis device - Google Patents
Combined centrifugal disc and analysis device Download PDFInfo
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- CN210487580U CN210487580U CN201921247158.3U CN201921247158U CN210487580U CN 210487580 U CN210487580 U CN 210487580U CN 201921247158 U CN201921247158 U CN 201921247158U CN 210487580 U CN210487580 U CN 210487580U
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Abstract
The utility model provides a combined centrifugal disc and an analysis device, wherein the combined centrifugal disc comprises a body, and the body is provided with an injection cavity, a quantitative cavity, a mixing cavity and a detection cavity which are mutually communicated; the heat conductor is arranged on the lower side surface of the body and is positioned on the lower side of the injection cavity; the light shading part is arranged on the upper side face or the lower side face of the body and is provided with a light shading part and a light transmission part, and the light transmission part corresponds to the detection cavity. The utility model has the advantages of simple structure, convenient operation, high analysis efficiency and the like.
Description
Technical Field
The utility model relates to a detect, in particular to combination formula centrifugation disc and analytical equipment.
Background
The portable biochemical analyzer is used as portable clinical diagnosis equipment, is oriented to most primary hospitals and supplements the traditional large biochemical analyzer. This is a huge market for manufacturers of portable biochemical analyzers.
At present, the commercially available portable biochemical analyzer and the matched detection chip are designed in a snap-in manner, so that the placement requirement is high and the operation is inconvenient; the peripheral curve of the reagent cavity in the detection chip is close to a concentric circle, so that liquid residue is easily caused when liquid is emptied, and the test result is influenced; the detection chip is positioned by the side reflecting prism, so that the difficulty and the cost of manufacturing the die are greatly increased; the reagent in the detection chip is heated by outer hot air mostly, and needs longer preheating time, and the mode is obviously inferior to contact heat conduction heating.
SUMMERY OF THE UTILITY MODEL
In order to solve the defects in the prior art, the utility model provides a combined centrifugal disc which has simple structure, convenient heating and no residue.
The utility model aims at realizing through the following technical scheme:
a combined centrifugal disc comprises a body, wherein the body is provided with an injection cavity, a quantitative cavity, a mixing cavity and a detection cavity which are communicated with each other; the unitized centrifuge disc further comprises:
the heat conductor is arranged on the lower side surface of the body and is positioned on the lower side of the injection cavity;
the light shading part is arranged on the upper side face or the lower side face of the body and is provided with a light shading part and a light transmission part, and the light transmission part corresponds to the detection cavity.
The utility model aims at providing a still analytical equipment based on combination formula centrifugation disc, this utility model purpose can be realized through following technical scheme:
an analysis device comprises a combined centrifugal disc, a motor, a rotating disc and an optical detection module; the centrifugal disc is a combined centrifugal disc which is suitable for being fixed on a rotating disc driven by the motor.
Compared with the prior art, the utility model discloses the beneficial effect who has does:
1. the heat conductor and the shading part are combined on the basis of the body of the conventional centrifugal disk, so that the combined centrifugal disk with excellent performance is obtained;
the lower side surface of the body is provided with the heat conductor, so that external heat is conducted to the sample and/or the diluent injected into the cavity through the heat conductor, and the heating effect is good;
meanwhile, the shading part is arranged on the upper side surface or the lower side surface of the body, so that the detection light can only enter the detection cavity through the light transmission part and cannot pass through the shading part, the stray light interference between the detection cavities is avoided, and the accuracy of liquid detection in the detection cavity is improved;
2. when the combined centrifugal disk is applied, the heat conductor fixed on the body and the rotating disk bearing the centrifugal disk are made of ferromagnetic materials, so that the rotating disk firmly adsorbs the centrifugal disk, looseness is prevented, and positioning accuracy is improved;
3. the design that the rotation radiuses of the quantitative cavity and/or the mixing cavity are different enables all liquid in the cavity to be discharged from the outlet, liquid residues are prevented, and analysis accuracy is improved;
an outlet is provided at the corner of the second portion remote from the first portion and the other corner remote from the first portion has a ramp configuration such that during rotation, all of the liquid in the second portion is expelled from the outlet, preventing liquid retention.
Drawings
The disclosure of the present invention will become more readily understood with reference to the accompanying drawings. As is readily understood by those skilled in the art: these drawings are only intended to illustrate the technical solution of the present invention and are not intended to limit the scope of the present invention. In the figure:
FIG. 1 is a schematic view of an analysis apparatus according to an embodiment of the present invention;
FIG. 2 is a schematic view of a heat conductor, a body and a light shielding member according to an embodiment of the present invention;
FIG. 3 is a schematic diagram of a centrifugal disk structure according to an embodiment of the present invention;
fig. 4 is a partial schematic view of a centrifugal disk according to an embodiment of the present invention.
Detailed Description
Fig. 1-4 and the following description depict alternative embodiments of the invention to teach those skilled in the art how to make and reproduce the invention. For the purpose of teaching the present invention, some conventional aspects have been simplified or omitted. Those skilled in the art will appreciate variations or substitutions from these embodiments that will be within the scope of the invention. Those skilled in the art will appreciate that the features described below can be combined in various ways to form multiple variations of the invention. Accordingly, the present invention is not limited to the following alternative embodiments, but is only limited by the claims and their equivalents.
Example 1:
fig. 1 schematically shows a schematic structural diagram of an analysis apparatus according to embodiment 1 of the present invention, and as shown in fig. 1, the analysis apparatus includes:
the motor 91 and the rotating disc 71 driven by the motor;
fig. 2 is a schematic structural diagram of a combined centrifugal disk according to an embodiment of the present invention, and as shown in fig. 2, the combined centrifugal disk includes:
a body 11, as shown in fig. 3, the body 11 is provided with an injection cavity 12, a quantitative cavity 17, a mixing cavity 19, a detection cavity 13 and a central hole 18 which are communicated with each other;
the heat conductor 21 is arranged on the lower side surface of the body 11 and is positioned at the lower side of the injection cavity 12;
a light shielding member 61 having a light transmitting portion 64 and a light shielding portion 65, and provided on an upper side surface of the main body 11, the detection light passing through the light transmitting portion 64 being allowed to enter only the detection chamber 13;
the light source 81 and the detector 82 are respectively arranged at the upper side and the lower side of the centrifugal disc, and detection light emitted by the light source 81 sequentially passes through the light-transmitting part 64 of the light-shielding member 61 and liquid in the detection cavity 13 and then is received by the detector 82, namely, transmission type detection is adopted;
fig. 4 schematically shows a partial structure of a centrifuge disk, and as shown in fig. 4, in order to prevent the liquid from remaining, the quantitative chamber and/or the mixing chamber further includes:
a first portion 31 and a second portion 32, the radius of rotation of the bottom wall of the second portion 32 being greater than the radius of rotation of the first portion 31; a steep slope structure with a sharply increased rotating radius is arranged at the junction of the bottom walls of the first part 31 and the second part 32;
and the outlet 34 is arranged at the corner of the second part far away from the first part, and the other corner of the second part far away from the first part opposite to the corner is a slope structure 33, so that the residual quantity of the liquid is effectively reduced.
In order to fix the centrifugal plate firmly on the rotating disk, further, ferromagnetic materials are adopted for the heat conductor and the rotating disk of the centrifugal plate.
The working process of the analysis device comprises the following steps:
(A1) respectively injecting a sample and a diluent into the injection cavity;
(A2) a rotating disc heats the heat conductor, so that the sample and the diluent in the injection cavity are heated;
(A3) respectively feeding the quantified sample and the diluent into a mixing cavity for reaction, and feeding the reacted liquid into a detection cavity;
(A4) the detection light sequentially passes through the light-transmitting part of the light-shielding part and the liquid in the detection cavity, the detector receives a light signal, and the parameters of the sample are obtained by analyzing the light signal.
Example 2:
an application example of the analysis device according to embodiment 1 of the present invention to whole blood analysis.
In this application, as shown in fig. 1-2, the thermal conductor 21 is of annular configuration and has three extensions 22 along a central axis parallel to the central axis thereof, said extensions 22 being adapted to be clamped in the central hole 18 of the body 11; the projection of the injection cavity on the horizontal plane completely falls within the projection of the heat conductor on the horizontal plane;
the light shielding part 61 is of a circular ring structure, is made of light-tight materials, and is provided with a plurality of uniformly distributed through holes 64 serving as light-transmitting parts, the specific number of the through holes is equal to the number of the detection cavities, and the through holes 64 correspond to the detection cavities up and down; the diameter of the through hole 64 is smaller than that of the detection cavity; the outer edge of the shading piece is provided with a plurality of extension parts 62 along the direction parallel to the central axis of the shading piece, and the length of each extension part 62 is not more than the thickness of the body; the end of the extension 62 has a projection 63 toward the center axis; corresponding to the structure, the outer edge of the body 11 is provided with a plurality of grooves 14 suitable for the extension parts 62 to be clamped, the number of the grooves 14 is equal to that of the extension parts 62, the grooves 14 extend along the direction parallel to the central axis of the body 11, and the width of the grooves 14 is matched with that of the extension parts 62, so that the body 11 is clamped into the shading piece 61 and does not move relatively; the heat conductor and the rotating disc are made of ferromagnetic materials;
the injection cavity comprises a sample injection cavity and a diluent injection cavity, and the maximum rotation radius of the sample injection cavity is equal to that of the diluent injection cavity; the sample injection cavity is communicated with the first quantitative cavity, and the minimum rotation radius of the first quantitative cavity is larger than the maximum rotation radius of the sample injection cavity; the first quantitative cavity is communicated with the mixing cavity; the diluent injection cavity is communicated with a second quantitative cavity, and the minimum rotation radius of the second quantitative cavity is larger than the maximum rotation radius of the diluent injection cavity; the second quantitative cavity is communicated with the mixing cavity;
the second dosing chamber and the mixing chamber each comprise: the rotary radius of the bottom wall of the second part is larger than that of the first part; the joint of the bottom walls of the first part and the second part is provided with a steep slope structure with a sharply changed rotating radius; the corner of the second part far away from the first part is provided with an outlet, and the other corner far away from the first part opposite to the corner is of a slope structure, so that the liquid of the first part completely enters the second part during rotation and then completely enters the corner with the outlet and is completely discharged;
the second quantitative cavity is communicated with the mixing cavity through a first channel, the first channel comprises a first bending part and a first flow channel, the first bending part is communicated with an outlet of the second quantitative cavity and extends along the direction departing from the rotation center of the body, and then extends along the direction facing the rotation center, the minimum rotation radius of the extending part is smaller than that of the second quantitative cavity, the flow channel is communicated with the minimum rotation radius of the first bending part and extends along the direction departing from the rotation center, the first flow channel is communicated with the mixing cavity, and the maximum rotation radius of the first flow channel is larger than that of the second quantitative cavity;
the mixing cavity is communicated with the detection cavity through a second channel; the second channel comprises a second bending part and a second flow channel, the second bending part is communicated with the outlet of the mixing cavity and extends along the direction departing from the rotation center of the body, and then extends along the direction towards the rotation center, and the minimum rotation radius of the extending part is smaller than that of the mixing cavity; the second flow passage is communicated with the minimum rotating radius of the second bending part and extends along the direction departing from the rotating center, the second flow passage is communicated with the detection cavity, and the maximum rotating radius of the second flow passage is larger than that of the mixing cavity;
the light shading part is arranged on the upper side surface of the body, the light source is arranged above the combined centrifugal disc, and the detector is arranged below the combined centrifugal disc.
The working process of the analysis device comprises the following steps:
(A1) the heat conductor and the rotating disc are attracted together by magnetism; the whole blood is injected into the sample injection cavity, and the diluent is injected into the diluent injection cavity;
(A2) the rotating disc heats the heat conductor, so that the sample and the diluent injected into the cavity are heated respectively;
(A3) the sample quantified by the first quantitative cavity and the diluent quantified by the second quantitative cavity respectively enter the mixing cavity and react, and the liquid is sent to the detection cavity;
(A4) the detection light sequentially passes through the through hole of the light shading piece and the liquid in the detection cavity, and after the interference of stray light is eliminated, the parameters of the sample are obtained by analyzing the light signals.
Example 3:
according to the utility model discloses an application example of analytical equipment in whole blood analysis of embodiment 1, different from embodiment 2 is:
1. the shading member has a first group of uniformly distributed through holes, and a second group of through holes are arranged between the first and the last of the uniformly distributed first group of through holes, namely, the first through hole, the second through hole, the last through hole and other through holes in the first group of through holes are arranged on a concentric circle of the shading member clockwise; the distance between the adjacent through holes in the first group of through holes is different from the distance between the second (group of) through holes; alternatively, the second through holes have a different pitch from the first set of through holes, the difference in pitch being used for positioning the centrifuge discs.
2. The light shielding member is arranged on the lower side surface of the body, so that the light source is arranged below the combined centrifugal disk sheet, and the detector is arranged above the combined centrifugal disk sheet.
3. The end of the second part far from the first part is provided with a groove, the corner of the groove far from the first part is provided with an outlet, the other corner of the groove far from the first part opposite to the corner is of a slope structure, so that the liquid of the first part completely enters the second part and then completely enters the groove in the rotating process, and the liquid in the groove is gathered at the corner with the outlet and completely discharged with the help of the slope structure, namely, the rotating radius of the bottom wall of the groove is gradually increased in the flowing direction of the liquid in the groove, and the rotating radius of the outlet is maximum.
The above embodiments have been given only by way of example of the through hole in the light-shielding member as the light-transmitting portion, but it is of course also possible to use a material transparent to the detection light as the light-transmitting portion.
Claims (9)
1. A combined centrifugal disc comprises a body, wherein the body is provided with an injection cavity, a quantitative cavity, a mixing cavity and a detection cavity which are communicated with each other; the method is characterized in that: the centrifuge disk further comprising:
the heat conductor is arranged on the lower side surface of the body and is positioned on the lower side of the injection cavity;
the light shading part is arranged on the upper side face or the lower side face of the body and is provided with a light shading part and a light transmission part, and the light transmission part corresponds to the detection cavity.
2. The unitized centrifuge disc of claim 1, wherein: the projection of the injection cavity on a horizontal plane falls within the projection of the heat conductor on the horizontal plane; the injection cavity comprises a sample injection cavity and a diluent injection cavity.
3. The unitized centrifuge disc of claim 1, wherein: the dosing and/or mixing chamber comprises: a first portion and a second portion, the radius of rotation of the bottom wall of the second portion being greater than the radius of rotation of the bottom wall of the first portion.
4. The unitized centrifuge disc of claim 3, wherein: the centrifuge disk further comprising:
the outlet is arranged at the corner of the second part far away from the first part, and the other corner of the second part far away from the first part is in a slope structure.
5. The unitized centrifuge disc of claim 1, wherein: the detection light passing through the light-transmitting portion can enter only the detection cavity.
6. The unitized centrifuge disc of claim 5, wherein: the light shielding piece is provided with a through hole, and the diameter of the through hole is not larger than that of the detection cavity.
7. An analysis device comprises a combined centrifugal disc, a motor, a rotating disc and an optical detection module; the method is characterized in that: the centrifugal disc is a combined centrifugal disc as claimed in any one of claims 1 to 6, which is adapted to be fixed to a rotating disc driven by the motor.
8. The analysis device of claim 7, wherein: the heat conductor and the rotating disc of the centrifugal disc are both made of ferromagnetic materials.
9. The analysis device of claim 7, wherein: the centrifuge disk has a central hole into which the rotating shaft of the rotating disk is adapted to be inserted.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201920466785 | 2019-04-09 | ||
| CN201920466785X | 2019-04-09 |
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| CN210487580U true CN210487580U (en) | 2020-05-08 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN201921247158.3U Active CN210487580U (en) | 2019-04-09 | 2019-08-04 | Combined centrifugal disc and analysis device |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110308096A (en) * | 2019-04-09 | 2019-10-08 | 宁波普芯生物科技有限公司 | Combined centrifugal disc, analytical equipment and method |
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- 2019-08-04 CN CN201921247158.3U patent/CN210487580U/en active Active
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110308096A (en) * | 2019-04-09 | 2019-10-08 | 宁波普芯生物科技有限公司 | Combined centrifugal disc, analytical equipment and method |
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