CN210376405U

CN210376405U - Full-automatic detection device

Info

Publication number: CN210376405U
Application number: CN201921333260.5U
Authority: CN
Inventors: 顾问
Original assignee: Guangzhou Improve Medical Technology Co ltd
Current assignee: Yangpu Medical Technology Co.,Ltd.
Priority date: 2019-08-16
Filing date: 2019-08-16
Publication date: 2020-04-21
Anticipated expiration: 2029-08-16

Abstract

The application relates to the technical field of medical detection, in particular to a full-automatic detection device. The device comprises: the reaction cup bearing disc is hinged above the first support, and the first rotary driving part is connected with the reaction cup bearing disc so as to control the reaction cup bearing disc to rotate; the reaction cup bearing plate is provided with reaction cup limiting holes, so that the reaction cups are fixed in the reaction cup limiting holes, the side wall of the reaction cup bearing plate is provided with through holes, and the through holes correspond to the reaction cups one to one; the light sensor is arranged in the light-tight casing, the light-tight casing is tightly matched with the side wall of the reaction cup bearing plate, so that the light-tight casing and the reaction cup bearing plate form a closed structure, and the light sensor is aligned with the reaction cup through the through hole. According to the method and the device, the liquid to be detected in the reaction cup does not need to be conveyed to the optical detection component, the luminous value of each reaction cup can be detected, and the technical defect of cross contamination caused by the fact that the same darkroom is used for detecting various liquids to be detected in the prior art is overcome.

Description

Full-automatic detection device

Technical Field

The application relates to the technical field of medical detection, in particular to a full-automatic detection device.

Background

Blood samples contain a variety of cells including, for example, white blood cells, red blood cells, and the like. Taking leukocytes as an example, the leukocytes are divided into five categories, namely neutrophils, eosinophils, basophils, monocytes and lymphocytes.

In recent years, with the continuous innovation of the medical industry, medical products using a point-of-care testing (POCT) device as a post are rapidly emerging and become an important mark for innovation of the medical industry. At present, the rapid detection generally adopts optical detection selected from chemiluminescence immunoassay technology, the chemiluminescence immunoassay adopts a full-automatic chemiluminescence immunoassay system and a semi-automatic chemiluminescence immunoassay system, the full-automatic chemiluminescence immunoassay system generally comprises a reaction cup feeding device, a sample adding device, a reagent adding device, a sample storage area, a reagent storage area, an incubation reaction device, a magnetic separation cleaning device, a chemiluminescence measuring device and a computer control system, the method is characterized in that the whole chemiluminescence immunoassay process can realize automatic treatment from reaction cup feeding, sample adding, reagent adding, incubation and cleaning to chemiluminescence measurement, does not need manual operation, has the advantages of large treatment capacity, time saving, high speed and efficiency and high automation degree, and is suitable for large hospitals with large sample treatment capacity.

The existing chemiluminescence measuring device is generally fixed in a reaction cup for measuring, and the detection principle is that a sample reaction solution in the reaction cup is sucked into a darkroom of the chemiluminescence measuring device, and the content of a measured substance in a sample is obtained by detecting the chemiluminescence numerical value of the sample reaction solution.

SUMMERY OF THE UTILITY MODEL

The application provides a full automatic checkout device, effectively solves among the prior art and utilizes same darkroom to detect the detection accuracy that multiple liquid that awaits measuring caused and hang down to and take place cross contamination's technical defect easily.

In view of this, the present application provides a full-automatic detection device, which includes:

a cuvette carrier member and an optical detection member;

the reaction cup bearing part comprises a first support, a reaction cup bearing disc and a first rotary driving part, the reaction cup bearing disc is hinged above the first support, and the first rotary driving part is connected with the reaction cup bearing disc so as to control the reaction cup bearing disc to rotate; the reaction cup bearing plate is provided with reaction cup limiting holes, so that the reaction cups are fixed in the reaction cup limiting holes, the side wall of the reaction cup bearing plate is provided with through holes, and the through holes correspond to the reaction cups one to one;

the optical detection part comprises a light-tight casing and an optical sensor, the optical sensor is arranged inside the light-tight casing, the light-tight casing is tightly matched with the side wall of the reaction cup bearing plate, so that the light-tight casing and the reaction cup bearing plate form a closed structure, and the optical sensor is aligned with the reaction cup through the through hole.

Preferably, the reaction cup bearing disc is of an annular structure.

Preferably, the first rotary drive means comprises a first rotary drive motor and a rotary platform;

the first rotary driving motor is rotatably connected with the rotary platform to control the rotary platform to rotate, and the rotary platform is fixedly connected with the reaction cup bearing plate.

Preferably, the reaction cup bearing part further comprises a temperature control platform, and the temperature control platform is fixed at the bottom end of the reaction cup bearing plate.

Preferably, the optical detection component further includes a base, a first direction driving component and a second direction driving component, the first direction driving component is fixed on the base, the second direction driving component is connected with the first direction driving component, the first direction driving component controls the second direction driving component to move in the first direction, the light-proof housing is connected with the second direction driving component, and the second direction driving component controls the light-proof housing to move in the second direction.

The optical sensor is conventional equipment, and comprises conventional equipment such as a photodiode, a photomultiplier tube (PMT), an avalanche photodiode (ADP), a photoelectric tube and the like, and the connection relationship of the optical sensor is conventional connection relationship.

Preferably, the optical detection component further comprises a light sensor mounting block, and the light-tight casing is mounted above the light sensor mounting block, so that the light-tight casing and the light sensor mounting block form a light sensor darkroom.

Preferably, the optical detection member further comprises a sample application needle; one end of the sample adding needle penetrates through the top wall of the light-tight casing and is arranged inside the light-tight casing.

Preferably, the full-automatic detection device further comprises a liquid storage cup bearing part, and the liquid storage cup bearing part is arranged at the center of the annular structure of the reaction cup bearing disc;

the liquid storage cup bearing part comprises a second support, a liquid storage cup bearing disc and a second rotary driving part, the liquid storage cup bearing disc is hinged above the second support, and the second rotary driving part is connected with the liquid storage cup bearing disc so as to control the liquid storage cup bearing disc to rotate;

the liquid storage cup bearing plate is provided with a liquid storage cup limiting hole so that the liquid storage cup can be fixed in the liquid storage cup limiting hole.

Preferably, the liquid storage cup carrier tray is of an annular structure.

Preferably, the liquid storage cup carrier plate has a disc-like structure.

The fully automatic detection device of the present application can detect chemiluminescent immunoreactions.

According to the technical scheme, the method has the following advantages:

the application designs a full-automatic detection device, liquid to be detected is arranged in a reaction cup, the liquid to be detected is a mixture of a sample and a chemiluminescent immunoreagent, the reaction cup is placed in a reaction cup limiting hole, when a first rotary driving component drives a reaction cup bearing disc to horizontally rotate, the reaction cup on the reaction cup bearing disc rotates to a position aligned with a light-tight shell, at the moment, the light-tight shell is tightly matched with the side wall of the reaction cup bearing disc, the light-tight shell and the reaction cup bearing disc form a closed structure, the liquid to be detected in the reaction cup emits light due to chemiluminescent immunity, the light emitted by the reaction cup is transmitted to an optical sensor through a through hole, the optical sensor detects the light source, information (such as content and the like) of substances to be detected in the liquid to be detected is obtained through calculation and analysis, and by analogy, the reaction cup bearing disc is only required to continuously rotate, the optical detection component and the reaction cup bearing disc, the liquid to be tested in each reaction cup can be detected. It is thus clear that this application bears dish and optical detection part through bearing the reaction cup and reforms transform, and the reaction cup bears the dish and sets up the through-hole, and optical detection part is provided with light-tight shell for light-tight shell bears the dish with the reaction cup and forms enclosed construction, and this enclosed construction is equivalent to optical detection's darkroom, and light sensor can detect the luminous value that obtains the liquid that awaits measuring in enclosed construction's environment through the through-hole. Therefore, the liquid to be detected in the reaction cups does not need to be conveyed to the optical detection component, the luminous value of each reaction cup can be detected, and the technical defect of cross contamination caused by the fact that the same darkroom is used for detecting various liquids to be detected in the prior art is overcome.

Drawings

Fig. 1 is a structural diagram of a full-automatic detection device provided in an embodiment of the present application;

FIG. 2 is a block diagram of the reaction cup carrier of FIG. 1;

FIG. 3 is a block diagram of the optical detection unit of FIG. 1;

FIG. 4 is another block diagram of the optical detection unit of FIG. 1;

FIG. 5 is a block diagram of a liquid storage cup carrier according to an embodiment of the present disclosure;

FIG. 6 is a top view of FIG. 1;

FIG. 7 is a block diagram of the substrate cleaning assembly of FIG. 6 of the present application;

FIG. 8 is a block diagram of the liquid transfer member of FIG. 6 of the present application;

FIG. 9 is a block diagram of a gripping member of the reaction cup of FIG. 6 of the present application;

FIG. 10 is a structural diagram of a magnetic bead homogenizing unit according to FIG. 6 of the present application;

fig. 11 is a structural view of the liquid transfer needle cleaning member of fig. 6 of the present application.

Detailed Description

The technical solutions of the embodiments of the present application will be described clearly and completely with reference to the accompanying drawings, and it is obvious that the described embodiments are some, but not all, of the embodiments of the present application. All other embodiments obtained by a person of ordinary skill in the art based on the embodiments in the present application without any creative effort belong to the protection scope of the embodiments in the present application.

In the description of the embodiments of the present application, it should be noted that the terms "center", "upper", "lower", "left", "right", "vertical", "horizontal", "inner", "outer", and the like indicate orientations or positional relationships based on the orientations or positional relationships shown in the drawings, and are only for convenience in describing the embodiments of the present application and simplifying the description, but do not indicate or imply that the referred devices or elements must have specific orientations, be configured in specific orientations, and operate, and thus, should not be construed as limiting the embodiments of the present application. Furthermore, the terms "first," "second," and "third" are used for descriptive purposes only and are not to be construed as indicating or implying relative importance.

In the description of the embodiments of the present application, it should be noted that the terms "mounted," "connected," and "connected" are to be construed broadly and may be, for example, fixedly connected, detachably connected, or integrally connected unless explicitly stated or limited otherwise; can be mechanically or electrically connected; they may be connected directly or indirectly through intervening media, or they may be interconnected between two elements. Specific meanings of the above terms in the embodiments of the present application can be understood in specific cases by those of ordinary skill in the art.

It should be understood that the present application is applied to a system for medical examination, please refer to fig. 1, fig. 1 is a structural diagram of a fully automatic examination apparatus provided in an embodiment of the present application, as shown in fig. 1, the embodiment of the present application includes a cuvette carrier 1 and an optical detection unit 2; the reaction cup bearing part 1 comprises a first support 1-1, a reaction cup bearing disc 1-2 and a first rotary driving part, the reaction cup bearing disc 1-2 is hinged above the first support 1-1, and the first rotary driving part is connected with the reaction cup bearing disc 1-2 so as to control the reaction cup bearing disc 1-2 to rotate; the reaction cup bearing plate 1-2 is provided with reaction cup limiting holes 1-4, so that the reaction cups are fixed in the reaction cup limiting holes 1-4, the side wall of the reaction cup bearing plate 1-2 is provided with through holes 1-5, and the through holes 1-5 correspond to the reaction cups one by one; the optical detection part 2 comprises a light-tight casing 2-1 and an optical sensor, the optical sensor is arranged inside the light-tight casing 2-1, the light-tight casing is tightly matched with the side wall of the reaction cup bearing disc 1-2, so that the light-tight casing 2-1 and the reaction cup bearing disc 1-2 form a closed structure, and the optical sensor is aligned with the reaction cup through the through hole 1-5.

The application designs a full-automatic detection device, liquid to be detected is arranged in a reaction cup, the liquid to be detected is a mixture of a sample and a chemiluminescent immunoassay reagent, the reaction cup is placed in a reaction cup limiting hole 1-4, when a first rotary driving part drives a reaction cup bearing disc 1-2 to horizontally rotate, the reaction cup on the reaction cup bearing disc 1-2 rotates to a position aligned with a light-tight shell 2-1, at the moment, the light-tight shell 2-1 is tightly matched with the side wall of the reaction cup bearing disc 1-2, the light-tight shell 2-1 and the reaction cup bearing disc 1-2 form a closed structure, the liquid to be detected in the reaction cup emits light due to chemiluminescent immunity, a light source emitted by the reaction cup is transmitted to an optical sensor through a through hole 1-5, the optical sensor detects the light source, and information (such as content and the like) of substances to be detected in the liquid to be detected is obtained through calculation and, by analogy, the optical detection component 2 can detect the liquid to be detected in each reaction cup only by continuously rotating the reaction cup bearing disc 1-2. Therefore, the reaction cup bearing disc 1-2 and the optical detection part 2 are modified, the reaction cup bearing disc 1-2 is provided with the through hole 1-5, the optical detection part 2 is provided with the light-tight shell 2-1, so that the light-tight shell 2-1 and the reaction cup bearing disc 1-2 form a closed structure, the closed structure is equivalent to a darkroom for optical detection, and the light sensor can detect in the environment of the closed structure through the through hole 1-5 to obtain the luminous value of the liquid to be detected. Therefore, the liquid to be detected in the reaction cups does not need to be conveyed to the optical detection component, the luminous value of each reaction cup can be detected, and the technical defect of cross contamination caused by the fact that the same darkroom is used for detecting various liquids to be detected in the prior art is overcome.

For easy understanding, please refer to fig. 2, fig. 2 is a structural diagram of the cuvette carrier of fig. 1, and as shown in fig. 2, the cuvette carrier plate 1-2 is a ring structure. The reaction cup limiting holes 1-4 can be arranged on the annular structure, and the through holes 1-5 are arranged on the outer wall of the annular structure, so that other devices can be arranged at the central position of the annular structure, and the space of the reaction cup bearing plate can be effectively utilized.

Further, the first rotation driving component 1-3 may be a conventional rotation driving device capable of driving rotation, and for easy understanding, please refer to fig. 2, specifically, the first rotation driving component 1-3 of the present embodiment includes a first rotation driving motor 1-6 and a rotation platform 1-7; the first rotary driving motor 1-6 is rotatably connected with the rotary platform 1-7, the first rotary driving motor 1-6 controls the rotary platform 1-7 to rotate, and the rotary platform 1-7 is fixedly connected with the reaction cup bearing disc 1-2. Preferably, the first rotary drive motor 1-6 may be a servo motor.

Further, the cuvette carrier 1 of this embodiment further includes a temperature control platform 1-8, and for easy understanding, referring to fig. 2, the temperature control platform 1-8 is fixed at the bottom end of the cuvette carrier tray 1-2. The temperature control platforms 1 to 8 are used to adjust the temperatures of the cuvettes of the cuvette carrier trays 1 to 2, and the temperature control platforms 1 to 8 may be conventional cooling and/or heating devices, such as heaters or refrigerators, and the details are not repeated in the embodiments of the present application. Specifically, the reaction cup bearing part 1 can further comprise support rods 1-9 and fixing blocks 1-10, the temperature control platform 1-8 can be fixedly connected with the fixing blocks 1-10 through the support rods 1-9, the fixing blocks 1-10 are fixed on the surfaces of the rotating platforms 1-7, and the rotating platforms 1-7 drive the temperature control platform 1-8 and the reaction cup bearing disc 1-2 to rotate through the fixing blocks 1-10.

For easy understanding, please refer to fig. 3, fig. 3 is a structural diagram of the optical detection component of fig. 1, as shown in fig. 3, the optical detection component 2 includes a light-tight casing 2-1 and a light sensor (not labeled in the figure), the optical detection component 2 is disposed on a side wall of the reaction cup bearing plate 1-2, a shape of the light-tight casing 2-1 can match with a shape of the reaction cup bearing plate 1-2, the light-tight casing 2-1 can form a light-tight cavity a by disposing a light-shielding sheet 2-2, the reaction cup bearing plate 1-2 can rotate in the light-tight cavity a, the light-tight casing 2-1 does not affect the rotation of the reaction cup bearing plate 1-2, the light-tight casing 2-1 and a closed structure formed by tightly fitting the side wall of the reaction cup bearing plate 1-2 can form a dark room of the optical detection component, the light sensor is aligned with the reaction cup through the through holes 1-5, so that the light sensor can detect the light value of the reaction cup through the through holes 1-5.

Further, the optical detection component 2 of the present embodiment further includes a base 2-3, a first direction driving component 2-4 and a second direction driving component 2-5, for easy understanding, please refer to fig. 4, fig. 4 is another structural diagram of the optical detection component of fig. 1, the first direction driving component 2-4 is fixed on the base 2-3, the second direction driving component 2-5 is connected with the first direction driving component 2-4, the first direction driving component 2-4 controls the second direction driving component 2-5 to move in the first direction X, the opaque housing 2-1 is connected with the second direction driving component 2-5, and the second direction driving component 2-5 controls the opaque housing 2-1 to move in the second direction Y. The first direction driving part 2-4 and the second direction driving part 2-5 can drive the light-tight casing 2-1 to move in the first direction X and the second direction Y, and can be matched with the reaction cup bearing discs 1-2 with different sizes, so that the optical detection part 2 can be always closely matched with the side walls of the reaction cup bearing discs 1-2, thereby effectively preventing light leakage of endogenous light, avoiding interference of external light sources and ensuring the accuracy of detection results.

The first direction driving component 2-4 can be an existing conventional device capable of performing telescopic motion, the first direction X in fig. 4 is a radial direction of the annular reaction cup bearing disc 1-2, and the second direction Y is an axial direction of the annular reaction cup bearing disc 1-2. The first direction driving component 2-4 can be a motor and screw rod structure, the second direction driving component 2-5 is fixed on the nut of the screw rod of the first direction driving component 2-4, and when the nut of the screw rod of the first direction driving component 2-4 makes linear reciprocating motion, the second direction driving component 2-5 is driven to make linear reciprocating motion; the first direction driving component 2-4 can also be a motor, a gear and a rack, the motor is connected with the gear, the gear is kneaded with the rack, the second direction driving component 2-5 is fixed on the rack of the first direction driving component 2-4, and when the rack of the first direction driving component 2-4 does linear reciprocating motion, the second direction driving component 2-5 is driven to do linear reciprocating motion.

Further, the optical sensor of the present embodiment is a very weak light pulse detection device based on the direct detection quantum confinement theory, such as a photon counter. The optical sensor of the present embodiment is an existing conventional device, and the optical sensor includes conventional devices such as a photodiode, a photomultiplier tube (PMT), an avalanche photodiode (ADP), and a photoelectric tube, and the connection relationship thereof is also an existing conventional connection relationship.

Further, referring to fig. 4, the optical detection component 2 of the present embodiment further includes a light sensor mounting block 2-6, the light sensor mounting block 2-6 is used for mounting the light sensor, and the light-tight enclosure 2-1 is mounted above the light sensor mounting block 2-6, so that the light-tight enclosure 2-1 and the light sensor mounting block 2-6 form a light sensor darkroom. The optical detection part 2 may be connected to the second direction driving part 2-5 through a light-tight case 2-1, and the optical detection part 2 may also be connected to the second direction driving part 2-5 through a light sensor mounting block 2-6.

Further, referring to fig. 4, the optical detection component 2 of the present embodiment further includes a sample adding needle 2-7; one end of the sample adding needle 2-7 penetrates through the top wall of the light-tight shell 2-1 to be arranged inside the light-tight shell 2-1, the other end of the sample adding needle 2-7 is connected with an external sample adding container, the sample adding needle 2-7 is used for pumping liquid into the reaction cup, and the liquid for sample adding of the sample adding needle 2-7 can be liquid for optical detection such as exciting liquid and enhancing liquid.

Further, the full-automatic detection device of the present embodiment further includes a liquid storage cup bearing member 3, for easy understanding, please refer to fig. 5, fig. 5 is a structural diagram of the liquid storage cup bearing member provided in the embodiment of the present application, and the liquid storage cup bearing member 3 is disposed in the center of the ring structure of the reaction cup bearing tray 1-2; the liquid storage cup bearing part 3 comprises a second support, a liquid storage cup bearing disc 3-1 and a second rotary driving part 3-2, the liquid storage cup bearing disc 3-1 is hinged above the second support, and the second rotary driving part 3-2 is connected with the liquid storage cup bearing disc 3-1 so as to control the liquid storage cup bearing disc 3-1 to rotate; the liquid storage cup bearing plate 3-1 is provided with a liquid storage cup limiting hole 3-3 so that the liquid storage cup is fixed in the liquid storage cup limiting hole 3-3. The liquid storage cup bearing part 3 is arranged in the hollow position of the annular structure of the reaction cup bearing disc 1-2, the space can be fully utilized, the occupied area of the full-automatic detection device is reduced, the liquid storage cup bearing disc 3-1 and the reaction cup bearing disc 1-2 respectively rotate around the same rotating shaft, and the first rotary driving part 1-3 and the second rotary driving part 3-2 are independent driving parts. The second rotary driving part 3-2 can be an existing conventional device which can drive the connecting object to do rotary motion, and the second rotary driving part 3-2 can comprise a second rotary driving motor and a rotary table; the second rotary driving motor is rotatably connected with the rotary table and is used for controlling the rotary table to rotate, and the rotary table is fixedly connected with the liquid storage cup bearing plate 3-1. Preferably, the second rotary drive motor may be a servo motor.

The liquid storage cup can be reaction liquid for chemiluminescence immunoassay or/and a sample to be detected, the sample can be liquid such as serum, blood, saliva, urine, ascites or exudates, and the liquid storage cup can be placed in the liquid storage cup limiting hole 3-3, so that the reaction liquid or/and the sample to be detected can be conveniently transferred into the reaction cup.

Further, the liquid storage cup tray 3-1 of the present embodiment is a ring-shaped structure or a disc-shaped structure. The liquid reservoir cup holder 3-1 of FIG. 1 is a disk-like structure, and the liquid reservoir cup holder 3-1 of FIG. 5 is a ring-like structure.

Further, referring to fig. 6, fig. 6 is a top view of fig. 1, the full-automatic detection device of this embodiment further includes a substrate cleaning component 4 and a magnetic component, the substrate cleaning component 4 is disposed on the periphery of the reaction cup bearing plate 1-2, the substrate cleaning component 4 is used for cleaning a substrate in the reaction cup, where the substrate in this embodiment is a substance participating in chemiluminescence immunity, specifically, a substance to be measured of a sample to be detected specifically binds with magnetic beads to form a substrate and is concentrated at the bottom of the reaction cup, the substrate cleaning component 4 is used for injecting a cleaning solution and sucking a supernatant of the substrate, and sucking away a substance not binding with the magnetic beads specifically, the magnetic component is disposed on a side surface of the reaction cup bearing plate 1-2, and the magnetic component is used for adsorbing the magnetic beads to a side surface of the reaction cup. For easy understanding, fig. 7 is a structural diagram of the substrate cleaning component of fig. 5 of the present application, and the substrate cleaning component 4 includes a cleaning support 4-5, a straight pipe 4-3, a curved pipe 4-4, a first direction driving component 4-1 and a second direction driving component 4-2, wherein the first direction X is a radial direction of the annular reaction cup bearing disk 1-2, and the second direction Y is an axial direction of the annular reaction cup bearing disk 1-2; the first direction driving part 4-1 is connected with the second direction driving part 4-2, the first direction driving part 4-1 controls the second direction driving part 4-2 to move in the first direction, the cleaning bracket 4-5 is connected with the second direction driving part 4-2, the second direction driving part 4-2 controls the cleaning bracket 4-5 to move in the second direction, the straight pipe 4-3 is fixed on the cleaning bracket 4-5, the curved pipe 4-4 is fixed on the cleaning bracket 4-5, the curved opening of the curved pipe 4-4 faces to the straight pipe 4-3, the first direction driving part 4-1 and the second direction driving part 4-2 control the position of the cleaning bracket 4-5, so that the straight pipe 4-3 is above the liquid level of the substrate in the reaction cup, the straight pipe 4-4 is filled with the cleaning liquid, diluting and uniformly mixing a substrate in a reaction cup, adsorbing cleaned magnetic beads to the side face of the reaction cup by a magnetic component, inserting a straight pipe 4-3 below the liquid level of the substrate in the reaction cup so as to suck a supernatant of the substrate, controlling the position of a cleaning bracket 4-5 by a first direction driving component 4-1 and a second direction driving component 4-2 so that the straight pipe 4-3 rises above the liquid level of the substrate in the reaction cup, conveying a cleaning liquid into the reaction cup by a curved pipe 4-4, cleaning the liquid level part of the substrate inserted into the reaction cup by the straight pipe 4-3 by the curved opening of the curved pipe 4-4 facing the straight pipe 4-3, and repeating the above processes for 2-4 times so as to clean the substrate in the reaction cup. The substrate cleaning section 4 may be a conventional one used for substrate cleaning.

Further, the full-automatic detection device of this embodiment further includes a liquid transfer component 5, for convenience of understanding, fig. 8 is a structural diagram of the liquid transfer component of fig. 5 in this application, and the liquid transfer component 5 may be an existing conventional device capable of driving rotation and expansion and contraction, and this application provides a specific liquid transfer component 5, the liquid transfer component 5 is disposed at the periphery of the reaction cup bearing tray 1-2, the liquid transfer component 5 is used for transferring the liquid of the liquid storage cup into the reaction cup of the reaction cup bearing tray 1-2, the liquid storage cup may be disposed on the liquid storage cup bearing tray 3-1, and the liquid storage cup may also be disposed at the periphery of the liquid transfer component 5; the liquid transfer component 5 comprises a rotary connecting rod 5-1 and a liquid transfer needle 5-2, the liquid pump is used for sucking liquid and releasing liquid by the liquid transfer needle 5-2, the liquid transfer needle 5-2 is fixed on a rotary connecting rod 5-1, the rotary connecting rod 5-1 is connected with the second direction driving component, the second direction driving component drives the rotary connecting rod 5-1 to do linear reciprocating movement in the second direction, the rotary connecting rod 5-1 is connected with the rotary direction driving component, the rotary direction driving component drives the rotary connecting rod 5-1 to do rotary movement around a rotary shaft of the Z direction driving component, the rotary direction is the Z direction, and the second direction Y is the axial direction of the annular reaction cup bearing disc 1-2.

Further, the full-automatic detection device of this embodiment still includes reaction cup gripping component 6, for easy understanding, fig. 9 is the structure diagram of reaction cup gripping component of this application fig. 5, reaction cup gripping component 6 can be for the equipment that current conventional drivable snatchs hand make linear reciprocating motion in first direction X and second direction Y and snatch, this application embodiment provides specific reaction cup gripping component 6, reaction cup gripping component 6 sets up in the periphery of reaction cup bearing plate 1-2, reaction cup gripping component 6 is used for snatching the reaction cup and takes away from reaction cup bearing plate 1-2. The reaction cup grabbing part 6 comprises a first direction driving part 6-1, a second direction driving part 6-2 and a grabbing wall 6-3, the first direction driving part 6-1 is connected with the second direction driving part 6-2, the first direction driving part 6-1 drives the second direction driving part 6-2 to do linear reciprocating motion in the first direction X, the grabbing wall 6-3 is connected with the second direction driving part 6-2, the second direction driving part 6-2 drives the grabbing wall 6-3 to do linear reciprocating motion in the second direction Y, and the grabbing wall 6-3 is a manipulator for grabbing the reaction cups.

Further, the full-automatic detection device of this embodiment still includes magnetic bead mixing part 7, and for the convenience of understanding, fig. 10 is the structure diagram of the magnetic bead mixing part of this application fig. 5, and magnetic bead mixing part 7 can be the conventional equipment that is used for mixing the magnetic bead, and this application embodiment is not specifically repeated.

Further, the full-automatic detection device of this embodiment further includes a liquid transfer needle cleaning component 8, for convenience of understanding, fig. 11 is a structural diagram of the liquid transfer needle cleaning component of fig. 5 in this application, the liquid transfer needle cleaning component 8 may be an existing conventional device for cleaning a liquid transfer needle, for example, an ultrasonic device, the liquid transfer needle 5-3 may be inserted into a cleaning liquid of the ultrasonic device, and the liquid transfer needle 5-2 is cleaned by ultrasonic vibration, which is not described in detail in this application.

It should be noted that the first direction driving component of the above embodiment may be a motor and screw rod structure, the second direction driving component is fixed on the nut of the screw rod of the first direction driving component, and when the nut of the screw rod of the first direction driving component makes linear reciprocating motion, the second direction driving component is driven to make linear reciprocating motion; the first direction driving component can also be a motor, a gear and a rack, the motor is connected with the gear, the gear is kneaded with the rack, the second direction driving component is fixed on the rack of the first direction driving component, and when the rack of the first direction driving component makes linear reciprocating motion, the second direction driving component 2-5 is driven to make linear reciprocating motion.

The device can be provided with a disc, and a liquid transfer needle, a liquid transfer needle cleaning component, a magnetic bead mixing component, a substrate cleaning component, an optical detection component and a reaction cup grabbing component which are arranged around the disc, and is arranged in the simplest structure, so that the space is saved to the greatest extent, and the simplest movement is used for completing full-automatic chemiluminescence immunoassay detection. Most of the existing full-automatic detection devices are provided with a plurality of discs, so that the detection devices are large in size and complex in structure.

The magnetic bead homogenizing member 7 and the liquid transfer pin washing member 8 may be provided on the outer periphery of the cuvette holder 1-2 or may be provided at a hollow position of the annular liquid-storing-cup holder 3-1.

It should be noted that, taking the cuvette carrier 1-2 as the center, the substrate cleaning component 4, the optical detection component 2 and the cuvette grabbing component 6 are sequentially arranged on the periphery of the cuvette carrier 1-2 in the counterclockwise direction or the clockwise direction and are tightly matched with the cuvette carrier 1-2, so as to realize the operation of the substances in the cuvette.

The device of the present application realizes a full-automatic chemiluminescence immunoassay detection according to the following steps, including:

s101: placing a reaction cup in a reaction cup limiting hole 1-4, placing a liquid storage cup in a liquid storage cup limiting hole 3-3, dividing the liquid storage cup into a reagent cup and a sample cup, placing a reagent required by chemiluminescence immunity in the reagent cup, placing the sample in the sample cup, placing a specific magnetic bead in a magnetic bead uniformly-mixing component 7, and starting the magnetic bead uniformly-mixing component 7 to uniformly mix the specific magnetic bead;

s102: starting the liquid transfer component 5 to transfer the sample in the sample cup into the reaction cup, and then transferring the liquid transfer needle 5-2 into the liquid transfer needle cleaning component 8 for cleaning; starting the liquid transfer component 5 to transfer the reagent in the reagent cup into the reaction cup, and then transferring the liquid transfer needle 5-2 into the liquid transfer needle cleaning component 8 for cleaning; starting the liquid transfer component 5 to transfer the specific magnetic beads of the magnetic bead uniform mixing component 7 to a reaction cup, and then transferring the liquid transfer needle 5-2 to the liquid transfer needle cleaning component 8 for cleaning;

s103: driving the reaction cup bearing disc 1-2 to horizontally rotate, and rotating the reaction cup to the cleaning position of the substrate cleaning part 4;

s104: driving the reaction cup bearing disc 1-2 to horizontally rotate, rotating the reaction cup to the optical detection position of the optical detection component 2, wherein the reaction cup can be filled with luminous excitation liquid in advance, or the luminous excitation liquid can be added into the optical detection component 2 through a sample adding needle 2-7, and the optical detection component 2 collects the signal of the reaction cup;

s105: driving the reaction cup bearing plate 1-2 to horizontally rotate, rotating the reaction cup to the reaction cup grabbing part 6, grabbing the reaction cup by the grabbing wall 6-3, moving the reaction cup to the reaction cup collecting box, and finishing.

The terms "first," "second," "third," "fourth," and the like in the description of the application and the above-described figures, if any, are used for distinguishing between similar elements and not necessarily for describing a particular sequential or chronological order. It is to be understood that the data so used is interchangeable under appropriate circumstances such that the embodiments of the application described herein are, for example, capable of operation in sequences other than those illustrated or otherwise described herein. Furthermore, the terms "comprises," "comprising," and "having," and any variations thereof, are intended to cover a non-exclusive inclusion, such that a process, method, system, article, or apparatus that comprises a list of steps or elements is not necessarily limited to those steps or elements expressly listed, but may include other steps or elements not expressly listed or inherent to such process, method, article, or apparatus.

It should be understood that in the present application, "at least one" means one or more, "a plurality" means two or more. "and/or" for describing an association relationship of associated objects, indicating that there may be three relationships, e.g., "a and/or B" may indicate: only A, only B and both A and B are present, wherein A and B may be singular or plural. The character "/" generally indicates that the former and latter associated objects are in an "or" relationship. "at least one of the following" or similar expressions refer to any combination of these items, including any combination of single item(s) or plural items. For example, at least one (one) of a, b, or c, may represent: a, b, c, "a and b", "a and c", "b and c", or "a and b and c", wherein a, b, c may be single or plural.

The above embodiments are only used for illustrating the technical solutions of the present application, and not for limiting the same; although the present application has been described in detail with reference to the foregoing embodiments, it should be understood by those of ordinary skill in the art that: the technical solutions described in the foregoing embodiments may still be modified, or some technical features may be equivalently replaced; and such modifications or substitutions do not depart from the spirit and scope of the corresponding technical solutions in the embodiments of the present application.

Claims

1. A full automatic checkout device which characterized in that includes:

a cuvette carrier member and an optical detection member;

2. The apparatus according to claim 1, wherein the reaction cup tray is a ring structure.

3. The fully automatic detection device according to claim 1, wherein the first rotary drive component comprises a first rotary drive motor and a rotary platform;

4. The apparatus according to claim 1, wherein the cuvette carrier further comprises a temperature control platform fixed to a bottom end of the cuvette carrier.

5. The apparatus according to claim 1, wherein the optical inspection unit further comprises a base, a first direction driving unit and a second direction driving unit, the first direction driving unit is fixed on the base, the second direction driving unit is connected to the first direction driving unit, the first direction driving unit controls the second direction driving unit to move in a first direction, the opaque housing is connected to the second direction driving unit, and the second direction driving unit controls the opaque housing to move in a second direction.

6. The fully automatic detection device of claim 1, wherein the optical detection component further comprises a light sensor mounting block, the light-tight enclosure being mounted over the light sensor mounting block such that the light-tight enclosure and the light sensor mounting block form a light sensor dark room.

7. The fully automatic detection device according to claim 1, wherein the optical detection component further comprises a sample application needle; one end of the sample adding needle penetrates through the top wall of the light-tight casing and is arranged inside the light-tight casing.

8. The fully automatic detection device according to claim 2, further comprising a liquid reservoir cup bearing member disposed at the center of the ring structure of the reaction cup bearing tray;

9. The apparatus according to claim 8, wherein the liquid storage cup tray is a ring-shaped structure.

10. The apparatus according to claim 8, wherein the liquid storage cup carrier is a disc-shaped structure.